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18 results on '"Queiroz, Artur T.L."'

3. An integrative multi-omics approach to characterize interactions between tuberculosis and diabetes mellitus

Author

Vinhaes, Caian L., Fukutani, Eduardo R., Santana, Gabriel C., Arriaga, María B., Barreto-Duarte, Beatriz, Araújo-Pereira, Mariana, Maggitti-Bezerril, Mateus, Andrade, Alice M.S., Figueiredo, Marina C., Milne, Ginger L., Rolla, Valeria C., Kristki, Afrânio L., Cordeiro-Santos, Marcelo, Sterling, Timothy R., Andrade, Bruno B., and Queiroz, Artur T.L.

Published
2024
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4. Novel stepwise approach to assess representativeness of a large multicenter observational cohort of tuberculosis patients: The example of RePORT Brazil

Author

Arriaga, María B., Amorim, Gustavo, Queiroz, Artur T.L., Rodrigues, Moreno M.S., Araújo-Pereira, Mariana, Nogueira, Betania M.F., Souza, Alexandra Brito, Rocha, Michael S., Benjamin, Aline, Moreira, Adriana S.R., de Oliveira, Jamile G., Figueiredo, Marina C., Turner, Megan M., Alves, Kleydson, Durovni, Betina, Lapa-e-Silva, José R., Kritski, Afrânio L., Cavalcante, Solange, Rolla, Valeria C., Cordeiro-Santos, Marcelo, Sterling, Timothy R., and Andrade, Bruno B.

Published
2021
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9. CD4 T cells are rapidly depleted from tuberculosis granulomas following acute SIV co-infection

Author

Foreman, Taylor W., primary, Nelson, Christine E., additional, Kauffman, Keith D., additional, Lora, Nickiana E., additional, Vinhaes, Caian L., additional, Dorosky, Danielle E., additional, Sakai, Shunsuke, additional, Gomez, Felipe, additional, Fleegle, Joel D., additional, Parham, Melanie, additional, Perera, Shehan R., additional, Lindestam Arlehamn, Cecilia S., additional, Sette, Alessandro, additional, Brenchley, Jason M., additional, Queiroz, Artur T.L., additional, Andrade, Bruno B., additional, Kabat, Juraj, additional, Via, Laura E., additional, and Barber, Daniel L., additional

Published
2022
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10. Host lipidome and tuberculosis treatment failure

Author

Shivakoti, Rupak, primary, Newman, John W., additional, Hanna, Luke Elizabeth, additional, Queiroz, Artur T.L., additional, Borkowski, Kamil, additional, Gupte, Akshay N., additional, Paradkar, Mandar, additional, Satyamurthi, Pattabiraman, additional, Kulkarni, Vandana, additional, Selva, Murugesh, additional, Pradhan, Neeta, additional, Shivakumar, Shri Vijay Bala Yogendra, additional, Natarajan, Saravanan, additional, Karunaianantham, Ramesh, additional, Gupte, Nikhil, additional, Thiruvengadam, Kannan, additional, Fiehn, Oliver, additional, Bharadwaj, Renu, additional, Kagal, Anju, additional, Gaikwad, Sanjay, additional, Sangle, Shashikala, additional, Golub, Jonathan E., additional, Andrade, Bruno B., additional, Mave, Vidya, additional, Gupta, Amita, additional, and Padmapriyadarsini, Chandrasekaran, additional

Published
2021
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13. Effect of Dysglycemia on Urinary Lipid Mediator Profiles in Persons With Pulmonary Tuberculosis.

Author

Arriaga, María B., Karim, Farina, Queiroz, Artur T.L., Araújo-Pereira, Mariana, Barreto-Duarte, Beatriz, Sales, Caio, Moosa, Mahomed-Yunus S., Mazibuko, Matilda, Milne, Ginger L., Maruri, Fernanda, Henrique Serezani, Carlos, Koethe, John R., Figueiredo, Marina C., Kritski, Afrânio L., Cordeiro-Santos, Marcelo, Rolla, Valeria C., Sterling, Timothy R., Leslie, Alasdair, and Andrade, Bruno B.

Abstract

Background: Oxidized lipid mediators such as eicosanoids play a central role in the inflammatory response associated with tuberculosis (TB) pathogenesis. Diabetes mellitus (DM) leads to marked changes in lipid mediators in persons with TB. However, the associations between diabetes-related changes in lipid mediators and clearance of M. tuberculosis (Mtb) among persons on anti-TB treatment (ATT) are unknown. Quantification of urinary eicosanoid metabolites can provide insights into the circulating lipid mediators involved in Mtb immune responses. Methods: We conducted a multi-site prospective observational study among adults with drug-sensitive pulmonary TB and controls without active TB; both groups had subgroups with or without dysglycemia at baseline. Participants were enrolled from RePORTBrazil (Salvador site) and RePORT-South Africa (Durban site) and stratified according to TB status and baseline glycated hemoglobin levels: a) TB-dysglycemia (n=69); b) TBnormoglycemia (n=64); c) non-TB/dysglycemia (n=31); d) non-TB/non-dysglycemia (n=29). We evaluated the following urinary eicosanoid metabolites: 11α-hydroxy-9,15- dioxo-2,3,4,5-tetranor-prostane-1,20-dioic acid (major urinary metabolite of prostaglandin E2, PGE-M), tetranor-PGE1 (metabolite of PGE2, TN-E), 9α-hydroxy11,15-dioxo-2,3,4,5-tetranor-prostane-1,20-dioic acid (metabolite of PGD2, PGD-M), 11-dehydro-thromboxane B2 (11dTxB2), 2,3-dinor-6-keto-PGF1α (prostaglandin I metabolite, PGI-M), and leukotriene E4 (LTE4). Comparisons between the study groups were performed at three time points: before ATT and 2 and 6 months after initiating therapy. Results: PGE-M and LTE4 values were consistently higher at all three time-points in the TB-dysglycemia group compared to the other groups (p<0.001). In addition, there was a significant decrease in PGI-M and LTE4 levels from baseline to month 6 in the TBdysglycemia and TB-normoglycemia groups. Finally, TB-dysglycemia was independently associated with increased concentrations of PGD-M, PGI-M, and LTE4 at baseline in a multivariable model adjusting for age, sex, BMI, and study site. These associations were not affected by HIV status. Conclusion: The urinary eicosanoid metabolite profile was associated with TBdysglycemia before and during ATT. These observations can help identify the mechanisms involved in the pathogenesis of TB-dysglycemia, and potential biomarkers of TB treatment outcomes, including among persons with dysglycemia. [ABSTRACT FROM AUTHOR]

Published
2022
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14. The Effect of Diabetes and Prediabetes on Anti-tuberculosis Treatment Outcomes: A Multicentric Prospective Cohort Study

Author

Arriaga, María B., primary, Araújo-Pereira, Mariana, additional, Barreto-Duarte, Beatriz, additional, Nogueira, Betânia, additional, Freire, Maria Vitória C.N.S., additional, Queiroz, Artur T.L., additional, Rodrigues, Moreno M.S., additional, Rocha, Michael S., additional, Souza, Alexandra B., additional, Spener-Gomes, Renata, additional, Carvalho, Anna Cristina C., additional, Figueiredo, Marina C., additional, Turner, Megan M., additional, Durovni, Betina, additional, Lapa-e-Silva, José R., additional, Kritski, Afrânio L., additional, Cavalcante, Solange, additional, Rolla, Valeria C., additional, Cordeiro-Santos, Marcelo, additional, Sterling, Timothy R., additional, and Andrade, Bruno B., additional

Published
2021
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18. Eosinophils are part of the granulocyte response in tuberculosis and promote host resistance in mice

Author

Bohrer, Andrea C., Castro, Ehydel, Hu, Zhidong, Queiroz, Artur T.L., Tocheny, Claire E., Assmann, Maike, Sakai, Shunsuke, Nelson, Christine, Baker, Paul J., Ma, Hui, Wang, Lin, Zilu, Wen, du Bruyn, Elsa, Riou, Catherine, Kauffman, Keith D., Moore, Ian N., Del Nonno, Franca, Petrone, Linda, Goletti, Delia, Martineau, Adrian R., Lowe, David M., Cronan, Mark R., Wilkinson, Robert J., Barry, Clifton E., Via, Laura E., Barber, Daniel L., Klion, Amy D., Andrade, Bruno B., Song, Yanzheng, Wong, Ka-Wing, and Mayer-Barber, Katrin D.

Abstract

Host resistance to Mycobacterium tuberculosis (Mtb) infection requires the activities of multiple leukocyte subsets, yet the roles of the different innate effector cells during tuberculosis are incompletely understood. Here we uncover an unexpected association between eosinophils and Mtb infection. In humans, eosinophils are decreased in the blood but enriched in resected human tuberculosis lung lesions and autopsy granulomas. An influx of eosinophils is also evident in infected zebrafish, mice, and nonhuman primate granulomas, where they are functionally activated and degranulate. Importantly, using complementary genetic models of eosinophil deficiency, we demonstrate that in mice, eosinophils are required for optimal pulmonary bacterial control and host survival after Mtb infection. Collectively, our findings uncover an unexpected recruitment of eosinophils to the infected lung tissue and a protective role for these cells in the control of Mtb infection in mice.

Published
2021
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