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139 results on '"Profire, Lenuta"'

1. Binary and Ternary Inclusion Complexes of Niflumic Acid: Synthesis, Characterization, and Dissolution Profile.

Author

Bouchekhou, Zohra, Hadj Ziane-Zafour, Amel, Lupascu, Florentina Geanina, Profire, Bianca-Ștefania, Nicolescu, Alina, Bostiog, Denisse-Iulia, Doroftei, Florica, Dascalu, Ioan-Andrei, Varganici, Cristian-Dragoș, Pinteala, Mariana, Profire, Lenuta, Pinteala, Tudor, and Bouzid, Bachir

Subjects
DRUG solubility, MOLECULAR weights, X-ray diffraction, ANTI-inflammatory agents, METHYLCELLULOSE
Abstract

Although niflumic acid (NA) is one of the most used non-steroidal anti-inflammatory drugs, it suffers from poor solubility, low bioavailability, and significant adverse effects. To address these limitations, the complexation of NA with cyclodextrins (CDs) is a promising strategy. However, complexing CDs with low molecular weight drugs like NA can lead to low CE. This study explores the development of inclusion complexes of NA with 2-hydroxypropyl-β-cyclodextrin (2HP-β-CD), including the effect of converting NA to its sodium salt (NAs) and adding hydroxypropyl methylcellulose (HPMC) on complex formation. Inclusion complexes were prepared using co-evaporation solvent and freeze-drying methods, and their CE and Ks were determined through a phase solubility study. The complexes were characterized using physicochemical analyses, including FT-IR, DSC, SEM, XRD, DLS, UV-Vis, 1H-NMR, and 1H-ROESY. The dissolution profiles of the complexes were also evaluated. The analyses confirmed complex formation for all systems, demonstrating drug–cyclodextrin interactions, amorphous drug states, morphological changes, and improved solubility and dissolution profiles. The NAs-2HP-β-CD-HPMC complex exhibited the highest CE and Ks values, a 1:1 host-guest molar ratio, and the best dissolution profile. The results indicate that the NAs-2HP-β-CD-HPMC complex has potential for delivering NA, which might enhance its therapeutic effectiveness and minimize side effects. [ABSTRACT FROM AUTHOR]

Published
2024
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6. Complexes of Ibuprofen Thiazolidin-4-One Derivatives with β-Cyclodextrin: Characterization and In Vivo Release Profile and Biological Evaluation

Author

Vasincu, Ioana Mirela, primary, Apotrosoaei, Maria, additional, Lupascu, Florentina, additional, Iacob, Andreea-Teodora, additional, Giusca, Simona-Eliza, additional, Caruntu, Irina-Draga, additional, Marangoci, Narcisa-Laura, additional, Petrovici, Anca Roxana, additional, Stanciu, Gabriela Dumitrita, additional, Tamba, Bogdan-Ionel, additional, Profire, Bianca-Stefania, additional, Focsa, Alin-Viorel, additional, Pinteala, Mariana, additional, and Profire, Lenuta, additional

Published
2023
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7. Modern Approaches in Wounds Management

Author

Tatarusanu, Simona-Maria, primary, Lupascu, Florentina-Geanina, additional, Profire, Bianca-Stefania, additional, Szilagyi, Andrei, additional, Gardikiotis, Ioannis, additional, Iacob, Andreea-Teodora, additional, Caluian, Iulian, additional, Herciu, Lorena, additional, Giscă, Tudor-Catalin, additional, Baican, Mihaela-Cristina, additional, Crivoi, Florina, additional, and Profire, Lenuta, additional

Published
2023
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14. The synthesis, characterization and biological evaluation of a new nitric oxide donor agent

Author

Profire Lenuta, Apotrosoaei Maria, Oprea Anca, Brebu Mihai, Lupascu Florentina, Lupusoru Elena Catalina, and Vasile Cornelia

Subjects
synthesis, xanthine, acethaminophen, characterization, toxicity, anti-inflammatory, Chemistry, QD1-999
Abstract

The synthesis of a new xanthine nitric oxide donor (TSP-81) has been discussed. The designed compound includes two structural moieties - theophylline (1,3-dimethylxanthine) and acetaminophen (4-hydroxyacetanilide) linked by the nitric oxide donor alkyl chain as a spacer. The compound has been characterized by microanalysis (CHN), 1H-NMR, 13C-NMR, FT-IR, UV-vis, TG and DTG. The thermal behaviour showed that TSP-81 melts with decomposition, in four steps, the most important ones being the 2nd one (the registered weight loss being 17.6 %) and the 3rd one (with a registered weight loss of 30.4 %). The toxicity degree, the anti-inflammatory effect and the ability of releasing nitric oxide of the TSP-81 have also been evaluated. The biological assays established that TSP-81 exhibits enhanced biological properties such as lower toxicity and higher anti-inflammatory effect in reference with theophylline and acetaminophen, the drugs used as parents molecules. The TSP-81 is approximately 2 times more active than theophylline and 4 times more active than acetaminophen in reducing cotton pellet-granuloma formation. Furthermore, the release of nitric oxide (NO) appears to have an important contribution to enhancing the anti-inflammatory effect.

Published
2014
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18. Synthesis of novel series of 3,5-disubstituted imidazo[1,2- \textitd ] [1,2,4]thiadiazoles involving S _\textrmN Ar and Suzuki–Miyaura cross-coupling reactions

Author

Pescheteau, Clémentine, Place, Matthieu, Sava, Alexandru, Nunes, Lea, Profire, Lenuta, Routier, Sylvain, Buron, Frederic, Institut de Chimie Organique et Analytique (ICOA), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université d'Orléans (UO)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), University of Medicine and Pharmacy 'Grigore T.Popa' Iasi (UMF lasi), and ANR-17-CE07-0030,RA2DoSt,Renouveau dans le traitement de la maladie d'Alzheimer et de la trisomie 21 : cibler simultanément les kinases et la neuroinflammation(2017)

Subjects
[CHIM.ORGA]Chemical Sciences/Organic chemistry
Abstract

A convenient design of 3,5-disubstituted imidazo[1,2- d ][1,2,4]thiadiazoles is reported from 2-mercaptoimidazole, which afforded a versatile platform that was then used to access a variety of original heterocycles. , The first access to 3,5-disubstituted imidazo[1,2- d ][1,2,4]thiadiazole derivatives is reported. The series were generated from 2-mercaptoimidazole, which afforded the key intermediate bearing two functional positions. The S N Ar reactivity toward tosyl release at the C-3 position was investigated and a regioselective electrophilic iodination in C-5 position was performed to allow a novel C–C bond using Suzuki–Miyaura reaction. Palladium-catalyzed cross-coupling conditions were optimized. A representative library of various boronic acids was employed to establish the scope and limitations of the method. To complete this methodological study, the influence of the nature of the C-3 imidazo[1,2- d ][1,2,4]thiadiazole substitutions on the arylation in C-5 was investigated.

Published
2022

35. Prevalence of Physiological, Pathological and Behavioral Risk Factors in Patients Treated with Antidiabetic Sulfonylureas

Author

Confederat Luminita, Hăncianu Monica, Stefan Roxana, Constantin Sandra, and Profire Lenuta

Subjects
behavioral, medicine.medical_specialty, business.industry, physiological, nutritional and metabolic diseases, Behavioral risk, Internal medicine, diatetic patients, risk factors, Medicine, pathological, In patient, General Pharmacology, Toxicology and Pharmaceutics, business, General Dentistry, Pathological
Abstract

Diabetes mellitus is an important public health problem because of its increased incidence and its devastating complications. In addition to this, it was observed an increase in prevalence for diabetes risk factors. The aim of this study was to evaluate the frequency of the pathophysiological and behavioral risk factors among patients treated with oral hypoglycemic sulfonylureas. Material and methods: It were analyzed the observation sheets of 200 patients ambulatory treated at the “Providența” Medical Center. Results and discussions: Most of the patients were aged over 65 years, being 48.5% women and 51.5% men. The obesity was the most frequent (88%) risk factor in patients; the majority of them were included in the “overweight” and “first- degree obesity” class (72%). Regarding associated comorbidities, hypertension was found in 77% of cases, followed by dyslipidemia. In terms of physiological and behavioral aspects, age and alcohol consumption were predominant. Conclusions: A significant percentage of diabetic patients treated with hypoglycemic sulfonylureas present a high prevalence of the risk factors and even two or three factors associated.

Published
2015

39. List of Contributors

Author

Baican, Mihaela Cristina, Bračič, Matej, Cheaburu-Yilmaz, Catalina Natalia, Chiriac, Aurica P., Constantin, Sandra Madalina, Corciova, Andreia, Diaconu, Alina, Karasulu, Hatice Yesim, Koseva, Neli, Margineanu, Anca, Mitova, Violeta, Munteanu, Bogdanel Silvestru, Neamtu, Iordana, Nistor, Manuela Tatiana, Nita, Loredana Elena, Pamfil, Daniela, Peršin, Zdenka, Profire, Lenuţa, Ristić, Tijana, Rusu, Alina Gabriela, Šauperl, Olivera, Stoleru, Elena, Strnad, Simona, Todorova, Zornica, Tsacheva, Ivelina, Vasile, Cornelia, Yorgancioglu, Ali, Yilmaz, Onur, and Zemljič, Lidija Fras

Published
2019
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42. New antimicrobial chitosan derivatives for wound dressing applications

Author

Dragostin, Oana Maria, primary, Samal, Sangram Keshari, additional, Dash, Mamoni, additional, Lupascu, Florentina, additional, Pânzariu, Andreea, additional, Tuchilus, Cristina, additional, Ghetu, Nicolae, additional, Danciu, Mihai, additional, Dubruel, Peter, additional, Pieptu, Dragos, additional, Vasile, Cornelia, additional, Tatia, Rodica, additional, and Profire, Lenuta, additional

Published
2016
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