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Introduction: Biofilm-associated infections persist as a therapeutic challenge in contemporary medicine. The efficacy of antibiotic therapies is ineffective in numerous instances, necessitating a heightened focus on exploring novel antibiofilm medical strategies. Among these, iminosugars emerge as a distinctive class of compounds displaying promising biofilm inhibition properties. Methods: This study employs an in vivo wound infection mouse model to evaluate the effectiveness of PDIA in treating biofilm-associated skin wound infections caused by Staphylococcus aureus and Pseudomonas aeruginosa. Dermic wounds in mice were infected with biofilm-forming strains, specifically S. aureus 48 and P. aeruginosa 5, which were isolated from patients with diabetic foot, and are well-known for their strong biofilm formation. The subsequent analysis included clinical, microbiological, and histopathological parameters. Furthermore, an exploration into the susceptibility of the infectious strains to hydrogen peroxide was conducted, acknowledging its potential presence during induced inflammation in mouse dermal wounds within an in vivo model. Results: The findings revealed the efficacy of PDIA iminosugar against the S. aureus strain, evidenced by a reduction in bacterial numbers within the wound and the inflammatory focus. Discussion: This study suggests that PDIA iminosugar emerges as an active and potentially effective antibiofilm agent, positioning it as a viable treatment option for staphylococcal infections. [ABSTRACT FROM AUTHOR]

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Road transport is one of the key elements of economic development that helps build social and territorial cohesion. The economic development that has taken place in Poland over the last three decades has led to an improvement in road infrastructure throughout the country. Construction of new roads and improvement of existing ones promotes economic development. However, as the number of cars increases, so does the level of air emissions. In reducing pollutant emissions, the analysis of the technological possibilities used and the improvement of their efficiency with the simultaneous minimization of generated pollution is also of particular importance. The purpose of the publication is to present development trends in road transport in Poland and the possibility of reducing emissions in this respect. The method of analysing strategic documents and statistical data was used to achieve this goal. Moreover, the article shows perspectives for reducing the level of emissions from road transport and refers to the assumptions related to the modernization of the transport sector and reducing its share in carbon emissions and its sustainable development in cities. [ABSTRACT FROM AUTHOR]