661 results on '"Pilch, B."'
Search Results
2. Sulphate uptake and xylem loading of young pea (Pisum sativum L.) seedlings
- Author
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Herschbach, C., Pilch, B., Tausz, M., Rennenberg, H., and Grill, D.
- Published
- 2002
3. Expression of KIT (CD117) in Neoplasms of the Head and Neck: An Ancillary Marker for Adenoid Cystic Carcinoma
- Author
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Mino, M, Pilch, B Z, and Faquin, W C
- Published
- 2003
- Full Text
- View/download PDF
4. Langmuir–Blodgett layers of metal complexes of 4,4′-bis-(1-butyl-pentyl)-[2,2′]bipyridinyl-6,6′-diamine
- Author
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Oertel, U, Böhme, F, Friedel, P, Jehnichen, D, and Pilch, B
- Published
- 2003
- Full Text
- View/download PDF
5. A UNIQUE MUCIN-PRODUCING ADNEXAL CARCINOMA OF THE EYELID
- Author
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Allan, A., Barnhill, R., Wladis, W. P., Zimarowski, M. J., and Pilch, B.
- Published
- 2000
6. SEBACEOUS CARCINOMA OF THE EXTERNAL AUDITORY CANAL.
- Author
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Quinn, T R, Duncan, L M, and Pilch, B Z
- Published
- 1997
7. Weitere Untersuchungen über Relaxationserschelnungen in Fe-Si-C(N)-Legierungen
- Author
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Moroń, J. W., primary and Pilch, B., additional
- Published
- 1966
- Full Text
- View/download PDF
8. Specific inhibition of serine- and arginine-rich splicing factors phosphorylation, spliceosome assembly, and splicing by the antitumor drug NB-506
- Author
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Pilch, B., Allemand, E., Facompré, M., Bailly, C., Riou, J. -F, Soret, J., Jamal Tazi, Institut de Génétique Moléculaire de Montpellier (IGMM), Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM), and Adele, Sarah
- Subjects
Cultured ,Animals Carbazoles/*pharmacology DNA Topoisomerases ,Type I/antagonists & inhibitors Glucosides/*pharmacology Hela Cells Humans Leukemia P388/drug therapy/genetics/metabolism Mice Nuclear Proteins/*metabolism Phosphoproteins/*metabolism Phosphorylation/drug effects RNA Precursors/metabolism RNA Splicing/*drug effects RNA ,Messenger/genetics/metabolism RNA-Binding Proteins Spliceosomes/*drug effects/metabolism Tumor Cells ,[SDV.BBM] Life Sciences [q-bio]/Biochemistry, Molecular Biology ,[SDV.BBM]Life Sciences [q-bio]/Biochemistry, Molecular Biology - Abstract
Specific phosphorylation of serine- and arginine-rich pre-mRNA splicing factors (SR proteins) is one of the key determinants regulating splicing events. Several kinases involved in SR protein phosphorylation have been identified and characterized, among which human DNA topoisomerase I is known to have DNA-relaxing activity. In this study, we have investigated the mechanism of splicing inhibition by a glycosylated indolocarbazole derivative (NB-506), a potent inhibitor of both kinase and relaxing activities of topoisomerase I. NB-506 completely inhibits the capacity of topoisomerase I to phosphorylate, in vitro, the human splicing factor 2/alternative splicing factor (SF2/ASF). This inhibition is specific, because NB-506 does not demonstrate activity against other kinases known to phosphorylate SF2/ASF such as SR protein kinase 1 and cdc2 kinase. Importantly, HeLa nuclear extracts competent in splicing but not splicing-deficient cytoplasmic S100 extracts treated with the drug fail to phosphorylate SF2/ASF and to support splicing of pre-mRNA substrates containing SF2/ASF-target sequences. Native gel analysis of splicing complexes revealed that the drug affects the formation of the spliceosome, a dynamic ribonucleoprotein structure where splicing takes place. In the presence of the drug, neither pre-spliceosome nor spliceosome is formed, demonstrating that splicing inhibition occurs at early steps of spliceosome assembly. Splicing inhibition can be relieved by adding phosphorylated SF2/ASF, showing that extracts treated with NB-506 lack a phosphorylating activity required for splicing. Moreover, NB-506 has a cytotoxic effect on murine P388 leukemia cells but not on P388CPT5 camptothecin-resistant cells that carry two point mutations in conserved regions of topoisomerase I gene (Gly361Val and Asp709Tyr). After drug treatment, P388 cells accumulated hypophosphorylated forms of SR proteins and polyadenylated RNA in the nucleus. In contrast, neither SR protein phosphorylation nor polyadenylated mRNA distribution was affected in P388 CPT5-treated cells. Consistently, NB506 treatment altered the mRNA levels and/or splicing pattern of several tested genes (Bcl-X, CD 44, SC35, and Sty) in P388 cells but not in P388 CPT5 cells. The study shows for the first time that indolocarbazole drugs targeting topoisomerase I can affect gene expression by modulating pre-mRNA splicing through inhibition of SR proteins phosphorylation.
- Published
- 2001
9. Polycystic disease of the parotid glands
- Author
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Brown, E, August, M, Pilch, B Z, and Weber, A
- Subjects
Adult ,Cysts ,Biopsy ,Case Reports ,Magnetic Resonance Imaging ,Diagnosis, Differential ,Pregnancy Complications ,stomatognathic diseases ,stomatognathic system ,Pregnancy ,Humans ,Parotid Gland ,Female ,Parotid Diseases - Abstract
A 31-year-old woman had bilateral swelling of the parotid glands at 4 months of pregnancy. MR imaging showed marked enlargement of the parotid glands with increased signal on images with long repetition times. A diagnosis of polycystic disease of the parotid gland was made after biopsy and histologic examination. The radiographic and histologic features of this rare disease are discussed.
- Published
- 1995
10. Photolabile Carboxylic Acid Protected Terpolymers for Surface Patterning. Part 2: Photocleavage and Film Patterning
- Author
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Millaruelo, M., primary, Eng, L. M., additional, Mertig, M., additional, Pilch, B., additional, Oertel, U., additional, Opitz, J., additional, Sieczkowska, B., additional, Simon, F., additional, and Voit, B., additional
- Published
- 2006
- Full Text
- View/download PDF
11. [Early enzyme replacement therapy - hope for patients with mucopolysaccharidosis Type II].
- Author
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Orchel-Szastak K, Ptak K, Hrnciar K, Pilch B, Kania U, and Bik-Multanowski M
- Subjects
- Adolescent, Child, Humans, Infant, Newborn, Male, Time Factors, Treatment Outcome, Twins, Enzyme Replacement Therapy methods, Iduronate Sulfatase therapeutic use, Mucopolysaccharidosis II diagnosis, Mucopolysaccharidosis II drug therapy
- Abstract
We present an unexpected outcome of 10 years of enzyme replacement therapy of a boy with mucopolysaccharidosis type II. Due to a positive familiar history (severe disease course in a sibling) the diagnosis was established in the first month of life. Treatment with Elaprase was introduced two months later. Since then normal physical and mental development is observed. The patient presents only relatively large head circumference (+2.1 SD) and slight decrease of joints mobility. In our opinion, early introduction of enzyme replecement therapy could attenuate the disease course., (© Polish Society for Pediatric Endocrinology and Diabetology.)
- Published
- 2017
- Full Text
- View/download PDF
12. Excitation Energy Transfer between a First Generation Dendrimer and a Pyrene Derivative in Langmuir−Blodgett Multilayers
- Author
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Oertel, U., primary, Appelhans, D., additional, Friedel, P., additional, Jehnichen, D., additional, Komber, H., additional, Pilch, B., additional, Hänel, B., additional, and Voit, B., additional
- Published
- 2001
- Full Text
- View/download PDF
13. Monitoring of dipeptidyl peptidase-IV (DPP-IV) activity in patients with mucopolysaccharidoses types I and II on enzyme replacement therapy - Results of a pilot study.
- Author
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Hetmańczyk K, Bednarska-Makaruk M, Kierus K, Murawska-Izdebska S, Piekutowska-Abramczuk D, Pilch B, Tylki-Szymańska A, and Ługowska A
- Subjects
- Colorimetry, Dipeptidyl Peptidase 4 administration & dosage, Dipeptidyl Peptidase 4 blood, Humans, Mucopolysaccharidosis I drug therapy, Mucopolysaccharidosis II drug therapy, Pilot Projects, Dipeptidyl Peptidase 4 metabolism, Enzyme Replacement Therapy, Mucopolysaccharidosis I enzymology, Mucopolysaccharidosis II enzymology
- Abstract
Objectives: Mucopolysaccharidoses (MPSs) are a group of rare, inherited metabolic disorders which result from the lack of one of the lysosomal enzymes responsible for the degradation of glycosaminoglycans. Early recognition of MPS is important as it enables prompt implementation of enzyme replacement therapy (ERT). Dipeptidyl peptidase-IV (DPP-IV) is a ubiquitous ectopeptidase which activity has been associated with the cell surface protein CD26. Our aims were to investigate plasma DPP-IV activity in untreated patients with MPS type II in comparison to control individuals and to evaluate changes of DPP-IV during ERT in MPS I or II patients., Design and Methods: One MPS I and five MPS II patients were treated with ERT for up to 19 months. DPP-IV activity was measured in plasma with a colorimetric method using Gly-Pro-p-nitroanilide as a substrate. The reference intervals were observed in 17 healthy donors and in 9 MPS II individuals before ERT implementation., Results: DPP-IV activity ranged from 557 to 1959 nmol/ml/h (median and interquartile range: 1453 [955– 1554], n = 17) in plasma of control samples. In 9 untreated MPS II individuals, DPP-IV activity was higher and ranged from 2565 to 5968 nmol/ml/h (median and interquartile range: 4458 [4031–5161]). In 6 MPS patients receiving ERT, DPP-IV activity ranged from 2984 to 8628 nmol/ml/h. No declining tendency was observed during the treatment., Conclusions: DPP-IV activity is a good, newa nd valuable biomarker distinguishing between MPS and healthy individuals. However, it is not a useful marker of treatment efficacy and is unsuitable for monitoring.
- Published
- 2016
- Full Text
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14. Profiling Human Cerebrospinal Fluid (CSF) Endogenous Peptidome in Alzheimer's Disease.
- Author
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Wang D, Chen Z, and Li L
- Subjects
- Humans, Peptides chemistry, Tandem Mass Spectrometry, Protein Processing, Post-Translational, Glycosylation, Biomarkers cerebrospinal fluid, Amyloid beta-Peptides cerebrospinal fluid, Alzheimer Disease cerebrospinal fluid
- Abstract
Human cerebrospinal fluid (CSF) is a rich source for central nervous system (CNS)-related disease biomarker discovery due to its direct interchange with the extracellular fluid of the CNS. Though extensive proteome-level profiling has been conducted for CSF, studies targeting at its endogenous peptidome is still limited. It is more difficult to include the post-translational modifications (PTMs) characterization of the peptidome in the mass spectrometry (MS) analysis because of their low abundance and the challenge of data interpretation. In this chapter, we present a peptidomic workflow that combines molecular weight cut-off (MWCO) separation, electron-transfer and higher-energy collision dissociation (EThcD) fragmentation, and a three-step database searching strategy for comprehensive PTM analysis of endogenous peptides including both N-glycosylation and O-glycosylation and other common peptide PTMs. The method has been successfully adopted to analyze CSF samples from healthy donors, mild cognitive impairment (MCI), and Alzheimer's disease (AD) patients to provide a landscape of peptidome in different disease states., (© 2024. The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature.)
- Published
- 2024
- Full Text
- View/download PDF
15. Global epidemiology and socioeconomic correlates of hypopharyngeal cancer in 2020 and its projection to 2040: findings from GLOBOCAN 2020.
- Author
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Mousavi, Seyed Ehsan, Ilaghi, Mehran, Mirzazadeh, Yasaman, Jarrahi, Alireza Mosavi, and Nejadghaderi, Seyed Aria
- Subjects
HUMAN Development Index ,GROSS domestic product ,MEDICAL care costs ,HEAD tumors ,DEATH rate - Abstract
Background: Hypopharyngeal cancer (HC) comprises less than 5% of all malignant tumors in the head and neck. They often present at an advanced stage, thereby resulting in high mortalities. We aimed to report the epidemiology of HC globally, regionally, and nationally by age, sex, and socioeconomic status in 2020 and its projection to 2040. Methods: Data on HC incidence and mortality were extracted from the GLOBOCAN 2020. Age-standardized incidence rate (ASIR), age-standardized mortality rate (ASMR), and mortality-to-incidence ratios (MIRs) were calculated. We used bivariate correlation test, presenting results through Pearson’s correlation coefficient (r) to investigate the correlation between the metrics, human development index (HDI), and current healthcare expenditure (CHE) as a percentage of gross domestic product (GDP) (CHE/GDP). Results: In 2020, there were 84254 new HC cases globally (ASIR: 0.91 per 100000). Moreover, HC resulted in 38599 mortalities in 2020 (ASMR: 0.41). Furthermore, the global MIR of HC was 0.45. The ASIR and ASMR of HC were higher in men than women. Also, HDI demonstrated weak significant correlations with HC ASIR (r= 0.249, p<0.01), ASMR (r= 0.185, p<0.05), and MIR (r= 0.347, p<0.001). Moreover, a weak significant correlation was also observed between CHE/GDP and MIR (r= 0.279, p<0.001). The number of new HC cases and mortalities were estimated to increase by 50% and 55% in 2040, respectively. Conclusion: HC is a relatively rare cancer but with a substantial sex and geographic divide in distribution. Key priorities should thus include establishing high-quality cancer registries worldwide. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
16. Differential expression of transthyretin in papillary tumors of the endolymphatic sac and choroid plexus.
- Author
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Megerian, Cliff A., Pilch, Ben Z., Bhan, Atul K., McKenna, Michael J., Megerian, C A, Pilch, B Z, Bhan, A K, and McKenna, M J
- Abstract
Copyright of Laryngoscope is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 1997
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- View/download PDF
17. Mixed olfactory neuroblastoma and carcinoma. A report of two cases.
- Author
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Miller, Douglas C., Goodman, Max L., Pilch, Ben Z., Shi, Shan Rong, Dickersin, G. Richard, Halpern, Howard, Norris, Charles M., Miller, D C, Goodman, M L, Pilch, B Z, Shi, S R, Dickersin, G R, Halpern, H, and Norris, C M Jr
- Published
- 1984
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18. Radiation therapy of Waldeyer's ring lymphoma.
- Author
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Shimm, David S., Dosoretz, Daniel E., Harris, Nancy L., Pilch, Ben Z., Linggood, Rita M., Wang, C. C., Shimm, D S, Dosoretz, D E, Harris, N L, Pilch, B Z, and Linggood, R M
- Published
- 1984
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19. Anti-EBV serologic tests for nasopharyngeal carcinoma.
- Author
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Neel, H. Bryan, Pearson, Gary R., Weiland, Louis H., Taylor, William F., Lanier, Anne P., Huang, Andrew T., Goeppert, Helmut H., Hyams, Vincent J., Pilch, Ben Z., Levine, Paul H., Henle, Gertrude, Henle, Werner, Neel, H B 3rd, Pearson, G R, Weiland, L H, Taylor, W F, Goepfert, H H, Pilch, B Z, Lanier, A P, and Huang, A T
- Abstract
Sixty-three serum specimens from American patients with nasopharyngeal carcinoma were examined for antibodies to antigens associated with Epstein-Barr virus (EBV) and compared with 98 specimens from patients with other head and neck cancers, 133 from patients with benign head and neck diseases, and 96 from healthy donors. The level of antibody titers to EBV-associated antigens was correlated with nasopharyngeal carcinoma. The anti-EBV profile of elevated antibody titers directed against viral capsid antigen and early antigen was seen in undifferentiated and nonkeratinizing tumors but usually not in squamous cell tumors. Titers tended to rise with large increases in total tumor burden caused by distant metastases, often before clinical evidence of metastases. At the time of diagnosis, antibody-dependent cellular cytotoxicity testing was performed on serum samples from 46 of the patients with nasopharyngeal carcinoma. Pretreatment titers were usually low in patients in whom recurrence developed and were high in most of the patients who had a good response to treatment and have remained free of recurrence. [ABSTRACT FROM AUTHOR]
- Published
- 1980
- Full Text
- View/download PDF
20. Weitere Untersuchungen über Relaxationserscheinungen in Fe-Si-C(N)-Legierungen.
- Author
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Moroń, J. W. and Pilch, B.
- Published
- 1966
- Full Text
- View/download PDF
21. Excitation Energy Transfer between a First Generation Dendrimer and a Pyrene Derivative in Langmuir−Blodgett Multilayers
- Author
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Oertel, U., Appelhans, D., Friedel, P., Jehnichen, D., Komber, H., Pilch, B., Hanel, B., and Voit, B.
- Abstract
A first generation dendrimer
D1 was placed onto defined surfaces to study the excitation energy transfer betweenD1 as donor molecule and a pyrene containing polymer213 as acceptor molecule in Langmuir−Blodgett (LB) multilayers. Fluorescence experiments were carried out at several excitation wavelengths (220, 260, 312, and 341 nm).D1 formed a closed LB layer with a collapse area of 73 Å2 on an aqueous subphase, and a successful incorporation ofD1 in LB multilayers onto quartz plates was possible. At 220 nm excitation wavelength the adjacent donor and acceptor layers showed a dramatically increased fluorescence activity of the pyrene group in213 , which is about 20 times higher than that of the acceptor layer213 without the present donor layerD1 .213 quenches the fluorescence activity ofD1 more than 90% although only 5% of the maleic acid groups in213 are labeled with pyrene. The excitation energy transfer betweenD1 and213 may be assumed as a Förster energy transfer which was examined versus distance with two, four, six, and eight interlayers of an amphiphilic copolymer12 betweenD1 and213 .- Published
- 2002
22. Coronary artery abnormalities in Kawasaki disease.
- Author
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Zasada M, Poplawska K, Mazurek P, Rzucidlo-Hymczak A, Kuzma J, Kordon Z, Pilch B, Rudzinski A, and Pietrzyk JJ
- Subjects
- Child, Child, Preschool, Female, Humans, Male, Poland, Retrospective Studies, Coronary Vessel Anomalies pathology, Glucocorticoids therapeutic use, Mucocutaneous Lymph Node Syndrome drug therapy, Mucocutaneous Lymph Node Syndrome pathology
- Abstract
Introduction: Kawasaki disease is the number one cause of acquired heart disease among children in developed countries., Aim: The aim of the study was a retrospective analysis of the factors that may influence the persistence of coronary artery abnormalities in patients with Kawasaki disease., Materials and Methods: Analyzing the medical records of patients hospitalized in the University Children's Hospital of Krakow in the years 2005-2011 we collected the data of 28 patients diagnosed with Kawasaki disease. The group was divided into two subgroups, depending on the duration of the persistence of changes in the coronary arteries - A (n = 17) for up to 6 months, B (n = 11) - for more than 6 months. Both groups were analyzed for the presence of factors that may influence the course of the disease., Results: There were more boys in group A (11 boys (65%), 6 girls (35%)), whereas in group B the distribution was more uniform (6 boys (55%), 5 girls (45%)). The age of onset in group A was 37.9 months (SD 30.8), in group B 39.5 months (SD 16.7). 17.6% of patients in group A and 36.4% in group B were treated with glucocorticoids., Conclusions: In the group of patients in which coronary artery abnormalities disappeared more quickly, male and slightly older children dominated. The only difference observed between the 2 groups related to the frequency of the use of glucocorticoids, they were used more often in children, in whom coronary artery abnormalities persisted longer.
- Published
- 2013
23. Advances in spectrophotometric determination of Chromium(III) and Chromium(VI) in water: a review.
- Author
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Dawra, Nisha and Dabas, Neeru
- Subjects
TECHNOLOGICAL innovations ,CHROMIUM ions ,SEWAGE ,CHEMICAL reagents ,QUANTUM dots ,CHROMIUM compounds - Abstract
Due to the versatile usage and applications of chromium compounds in the industry worldwide, the chromium ions are present in the major effluents from a broad range of industries. Cr(VI) which is highly hazardous and carcinogenic poses a serious threat to the our ecosystem and human health even at very low concentration limits. Cr(III) ions are also toxic to aquatic life, but they are less harmful than Cr(VI) ions. Therefore, detection and analysis of the toxic Cr(VI) and Cr(III) ionic species in waste water are an utmost important area of research. Various chemical reagents and the different methods which require expensive instrumentation used in the past for detection and determination of the non-biodegradable Cr(VI) ions suffer from serious limitations. The present review summarises the use of spectrophotometric methods of determination of Cr(VI) and Cr(III) ions from aqueous solutions with high sensitivity, selectivity, accuracy and at lesser costs. The use of chemical reagents such as diphenylcarbazide (DPC) and several other dye-based reagents for spectrophotometric determination of hazardous Cr ions in water samples is discussed. Additionally, the use of DPC reagent in developing advanced technologies such as microfluidic detection system, microfluidic paper-based analytical devices (µPADs) and 3D printed device with online spectrophotometric detection system for onsite monitoring of water samples is elucidated. Different methods for selective speciation and preconcentration of Cr(VI) ions prior to spectrophotometric determination in water samples with very low concentrations (as low as ppb) of Cr ions are also described. The emerging trends in detection and determination of carcinogenic Cr(VI) ions involving the use of novel and innovative technologies and different categories of nanomaterials are also elucidated in the present review. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
24. Integrated analysis of the cerebrospinal fluid peptidome and proteome.
- Author
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Zougman A, Pilch B, Podtelejnikov A, Kiehntopf M, Schnabel C, Kumar C, and Mann M
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- Humans, Membrane Proteins metabolism, Peptide Hydrolases metabolism, Peptides analysis, Spinal Puncture, Tandem Mass Spectrometry, Cerebrospinal Fluid Proteins analysis, Neuropeptides analysis, Proteomics methods
- Abstract
Cerebrospinal fluid (CSF) is the only body fluid in direct contact with the brain and thus is a potential source of biomarkers. Furthermore, CSF serves as a medium of endocrine signaling and contains a multitude of regulatory peptides. A combined study of the peptidome and proteome of CSF or any other body fluid has not been reported previously. We report confident identification in CSF of 563 peptide products derived from 91 precursor proteins as well as a high confidence CSF proteome of 798 proteins. For the CSF peptidome, we use high accuracy mass spectrometry (MS) for MS and MS/MS modes, allowing unambiguous identification of neuropeptides. Combination of the peptidome and proteome data suggests that enzymatic processing of membrane proteins causes release of their extracellular parts into CSF. The CSF proteome has only partial overlap with the plasma proteome, thus it is produced locally rather than deriving from plasma. Our work offers insights into CSF composition and origin.
- Published
- 2008
- Full Text
- View/download PDF
25. [Difficulties in diagnosing febrile states in 21-month-old patient: case report].
- Author
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Pilch B, Legutko M, Pietrys D, and Pietrzyk JJ
- Subjects
- Blood Sedimentation, Diagnosis, Differential, Female, Humans, Infant, Anemia diagnosis, Fever of Unknown Origin diagnosis
- Abstract
A 21-month-old girl was admitted to our Department of Pediatrics to diagnose febrile states lasting for previous two weeks, anemia and increased erythrocyte sedimentation rate (ESR - erythrocyte sedimentation rate). The physical examination revealed the paleness of skin and oral mucosa, silent systolic murmur and hypotrophic constitution. The laboratory tests confirmed anemia and showed increased ESR and moderately increased C Reactive Protein (CRP - C Reactive Protein). The blood culture, the urine culture, the stool culture, the tests of the stool in direction of parasites and the serologic tests carried out in direction of infection caused by Toxoplasma ghondi, Mycoplasma pneumoniae, HAV, HCV, CMV, EBV and Parvovirus B19 were all negative. The chest X-ray picture and ultrasonographic examination of abdomen showed no abnormality. The consulting hematologist carried the bone marrow biopsy out--the bone marrow was poorly cellular. The urinary level of catecholamines and plasma level of neuron-specific enolase (NSE) were greatly increased. The computer tomography scan of head, neck, thorax and abdomen did not confirmed the presence of the tumor. Nevertheless the bone scintigraphy demonstrated the presence of foci of abnormally increased activity in left femur and the right hip-bone--pathognomonic of metastatic disease. During the hospitalization we did not observe the fever, but only the deepening anemia, weakness, irritability, limping and the presence of spectacle-shaped hematomas. The blood parameters temporarily were normal after blood transfusion. The patient was transmitted to the Department of Children's Oncology and Hematology. The trepanobiopsy of the bone marrow showed the presence of metastases of neuroblastoma. The magnetic resonance imaging (MRI) was made, but it did not revealed the presence of the primary tumor. The patient underwent a course of chemotherapy.
- Published
- 2007
26. Malignant Transformation of Dysplastic Vocal Fold Lesions: A Systematic Review and Meta-Analysis.
- Author
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Horton, Garret, Philteos, Justine, and Lin, R. Jun
- Published
- 2024
- Full Text
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27. Konaklama İşletmelerinde Piotroski F Skor ve Hisse Senedi Getirisi: Borsa İstanbul’da Bir Araştırma.
- Author
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KARADENİZ, Erdinç and İSKENDEROĞLU, Ömer
- Subjects
RATE of return on stocks ,ECONOMIC indicators ,FINANCIAL performance ,INVESTMENT policy ,STOCKS (Finance) - Abstract
Copyright of Çatalhöyük International Journal of Tourism & Social Research / Çatalhöyük Uluslararası Turizm ve Sosyal Araştırmalar Dergisi is the property of Catalhoyuk International Journal of Tourism & Social Research and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2024
- Full Text
- View/download PDF
28. How to Compute Whether Biomass Fuels Are Carbon Neutral.
- Author
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Ahamer, Gilbert
- Subjects
CARBON offsetting ,CARBON cycle ,BIOMASS ,ENERGY consumption ,GLOBAL warming ,BIOMASS energy ,SOLAR wind ,FOREST biomass - Abstract
Based on recent interest and on the importance of the ongoing climate change catastrophe, this article provides the basics of global carbon cycle modelling as required for the assessment of the degree of carbon neutrality of biomass energy, and its underlying dynamics. It is aimed at clarifying the question "Are biomass fuels carbon neutral?". The "Combined Energy and Biosphere Model" (CEBM) computes annual carbon flows including growth and decay of plants on 2.5 × 2.5° grid elements of the continents' surface and offers detailed results on the changes of after implementation of large-scale biomass energy strategies worldwide. The main (and possibly unexpected) effect is the long-term depletion of the soil organic compartment after extraction of biomass fuels. When comparing CEBM model runs using (i) biomass energy sources and (ii) carbon-free energy sources (such as solar or wind), it becomes quantitatively clear already on the theoretical level (i.e., even without taking into account efficiency losses) that biomass is only "half as carbon neutral" as ideally assumed, to express a rule of thumb—mainly because of soil carbon depletion. Still, biomass energy will play an important role when fighting global warming, even if efforts to lower energy demand are preferable as a fundamental strategy. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
29. Large-scale and high-confidence proteomic analysis of human seminal plasma.
- Author
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Pilch B and Mann M
- Subjects
- Adult, Humans, Male, Mass Spectrometry, Proteome physiology, Proteomics standards, Quality Control, Proteome analysis, Proteomics methods, Semen chemistry
- Abstract
Background: The development of mass spectrometric (MS) techniques now allows the investigation of very complex protein mixtures ranging from subcellular structures to tissues. Body fluids are also popular targets of proteomic analysis because of their potential for biomarker discovery. Seminal plasma has not yet received much attention from the proteomics community but its characterization could provide a future reference for virtually all studies involving human sperm. The fluid is essential for the survival of spermatozoa and their successful journey through the female reproductive tract., Results: Here we report the high-confidence identification of 923 proteins in seminal fluid from a single individual. Fourier transform MS enabled parts per million mass accuracy, and two consecutive stages of MS fragmentation allowed confident identification of proteins even by single peptides. Analysis with GoMiner annotated two-thirds of the seminal fluid proteome and revealed a large number of extracellular proteins including many proteases. Other proteins originated from male accessory glands and have important roles in spermatozoan survival., Conclusion: This high-confidence characterization of seminal plasma content provides an inventory of proteins with potential roles in fertilization. When combined with quantitative proteomics methodologies, it should be useful for studies of fertilization, male infertility, and prostatic and testicular cancers.
- Published
- 2006
- Full Text
- View/download PDF
30. [Causes of tic disorders in children].
- Author
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Prajsner B, Pilch B, Bałajewicz A, and Wesołowska E
- Subjects
- Brain diagnostic imaging, Brain pathology, Brain physiopathology, Child, Child, Preschool, Environment, Female, Hospitalization, Humans, Magnetic Resonance Imaging, Male, Projective Techniques, Self Concept, Severity of Illness Index, Tic Disorders physiopathology, Tomography, X-Ray Computed, Tic Disorders etiology, Tic Disorders rehabilitation
- Abstract
The Aim of the Work: Tic disorders are differentiated in their symptomatology and time of duration. Assessing the courses of tics can be crucial for more successful treatment. The aim of the study was to identify the egzogenic and endogenic causes of tic disorders., Material and Methods: The group of 20 children and adolescents, 6 girls and 14 boys, aged 4-16 years, with tic disorders were analysed. 8 of them were identified as having transient tics 6 chronic motor or vocal tics and 6 Tourette's syndrome. WISC-R, Terman-Merrill, and Raven, Bender-Koppitz and Benton tests and questionnaire "Who are you", and projection tests, talk to children and their parents were used., Results: The analysed group consisted of 70% boys. Gestational and perinatal risk factors were confirmed in 5 children, in similar percentage of different types of tics. In 20% of patients CT or MRI examination showed mild abnormalities, whereas EEG examination excluded epileptic discharges. Majority of children with tics demonstrated significant emotional sesitivity (70%) and tendency to repress fear and anger (60%). Hyperkinetic disorders co-existing with Tourette's syndrome in 3 patients, while learning disabilities were confirmed in 30% children with tic disorders. The presence of negative environmental factors which may contribute to trigger tics showed a half of children from analysed group. Above all children experienced stress in family (40%) and/or in school (20%). The biological and/or environmental factors were detected in 80% children. They were not established in four patients: in one with transient tics and in three with Tourrete's syndrome., Conclusion: The identification of biological and environmental factors is necessary in children with tics, because they are present and significant in majority of children. In 20% of children these factors were not confirmed and in this group other causes should be considered. Considering the risk of disordered emotional and social functioning of children with tics, leading in many cases to tics exacerbation, complex therapeutic care should be provided.
- Published
- 2005
31. Root uptake, transport, and metabolism of externally applied glutathione in Phaseolus vulgaris seedlings.
- Author
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Tausz M, Pilch B, Rennenberg H, Grill D, and Herschbach C
- Subjects
- Biological Transport, Active, Cysteine metabolism, Kinetics, Plant Roots metabolism, Seedlings metabolism, Glutathione metabolism, Phaseolus metabolism
- Abstract
The most abundant thiol in beans (Phaseolus vulgaris L. cv. Saxa) is the tripeptide homoglutathione (hGSH) rather than glutathione (GSH). At the whole-plant level the GSH content is less than 0.5% of the hGSH content. In the present study GSH was supplied to the roots of bean seedlings to test whether GSH can be taken up by roots and transported to the shoot. Therefore, 12-day-old plants were exposed to 1 mmol/L GSH for 4, 8 and 24 h prior to harvest. In response to this GSH exposure, elevated GSH contents were found in all tissues. After 4 h the GSH content increased in the roots from 1 +/- 1 to 22 +/- 2 nmol GSH g(-1) fresh weight (FW), in the leaves from 2 +/- 1 to 9 +/- 4 nmol GSH g(-1) FW, and in the apex from 30 +/- 5 to 75 +/- 4 nmol GSH g(-1) FW. These data indicate that GSH is taken up by bean roots and is transported to above above-ground parts of the plants. Roots exposed to GSH for 24 h contained 2-fold higher cysteine (Cys) and hGSH contents than the controls. Apparently, GSH taken up by the roots is not only loaded into the xylem but also partially degraded and used for hGSH synthesis.
- Published
- 2004
- Full Text
- View/download PDF
32. Specific inhibition of serine- and arginine-rich splicing factors phosphorylation, spliceosome assembly, and splicing by the antitumor drug NB-506.
- Author
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Pilch B, Allemand E, Facompré M, Bailly C, Riou JF, Soret J, and Tazi J
- Subjects
- Animals, HeLa Cells, Humans, Leukemia P388 drug therapy, Leukemia P388 genetics, Leukemia P388 metabolism, Mice, Phosphorylation drug effects, RNA Precursors metabolism, RNA, Messenger genetics, RNA, Messenger metabolism, RNA-Binding Proteins, Serine-Arginine Splicing Factors, Spliceosomes metabolism, Topoisomerase I Inhibitors, Tumor Cells, Cultured, Carbazoles pharmacology, Glucosides pharmacology, Nuclear Proteins metabolism, Phosphoproteins metabolism, RNA Splicing drug effects, Spliceosomes drug effects
- Abstract
Specific phosphorylation of serine- and arginine-rich pre-mRNA splicing factors (SR proteins) is one of the key determinants regulating splicing events. Several kinases involved in SR protein phosphorylation have been identified and characterized, among which human DNA topoisomerase I is known to have DNA-relaxing activity. In this study, we have investigated the mechanism of splicing inhibition by a glycosylated indolocarbazole derivative (NB-506), a potent inhibitor of both kinase and relaxing activities of topoisomerase I. NB-506 completely inhibits the capacity of topoisomerase I to phosphorylate, in vitro, the human splicing factor 2/alternative splicing factor (SF2/ASF). This inhibition is specific, because NB-506 does not demonstrate activity against other kinases known to phosphorylate SF2/ASF such as SR protein kinase 1 and cdc2 kinase. Importantly, HeLa nuclear extracts competent in splicing but not splicing-deficient cytoplasmic S100 extracts treated with the drug fail to phosphorylate SF2/ASF and to support splicing of pre-mRNA substrates containing SF2/ASF-target sequences. Native gel analysis of splicing complexes revealed that the drug affects the formation of the spliceosome, a dynamic ribonucleoprotein structure where splicing takes place. In the presence of the drug, neither pre-spliceosome nor spliceosome is formed, demonstrating that splicing inhibition occurs at early steps of spliceosome assembly. Splicing inhibition can be relieved by adding phosphorylated SF2/ASF, showing that extracts treated with NB-506 lack a phosphorylating activity required for splicing. Moreover, NB-506 has a cytotoxic effect on murine P388 leukemia cells but not on P388CPT5 camptothecin-resistant cells that carry two point mutations in conserved regions of topoisomerase I gene (Gly361Val and Asp709Tyr). After drug treatment, P388 cells accumulated hypophosphorylated forms of SR proteins and polyadenylated RNA in the nucleus. In contrast, neither SR protein phosphorylation nor polyadenylated mRNA distribution was affected in P388 CPT5-treated cells. Consistently, NB506 treatment altered the mRNA levels and/or splicing pattern of several tested genes (Bcl-X, CD 44, SC35, and Sty) in P388 cells but not in P388 CPT5 cells. The study shows for the first time that indolocarbazole drugs targeting topoisomerase I can affect gene expression by modulating pre-mRNA splicing through inhibition of SR proteins phosphorylation.
- Published
- 2001
33. Immunohistochemical study of nasopharyngeal carcinoma using monoclonal keratin antibodies
- Author
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Shi, S. R., Goodman, M. L., Bhan, A. K., Pilch, B. Z., Chen, L. B., and Sun, T. T.
- Subjects
Immunoenzyme Techniques ,stomatognathic diseases ,integumentary system ,Nasopharynx ,Carcinoma ,otorhinolaryngologic diseases ,Antibodies, Monoclonal ,Humans ,Keratins ,Nasopharyngeal Neoplasms ,Research Article - Abstract
Nasopharyngeal carcinoma (NPC) provides a unique opportunity to evaluate distinctive epidemiologic features and a possible etiologic relationship with Epstein-Barr virus (EBV) in human malignancy. The lack of a uniformly accepted pathologic classification for NPC has limited the application of this data, although the World Health Organization (WHO) developed a classification that may solve this problem. Monoclonal keratin antibodies were used for staining of NPC for evaluation of its assistance in diagnosis and classification. In the present immunohistochemical study, monoclonal keratin antibodies, designated AE1, AE2, and AE3, and a polyclonal keratin antibody (RAK) were used for study of the presence of keratin in 121 cases of NPC obtained from China and the United States. AE1 monoclonal antibody, which recognizes keratin protein classes 56.5K, 50K, and 40K, was shown to be the most sensitive and specific for NPC tumor cells among the keratin antibodies studied. In addition, some different keratin expression patterns could be identified between different kinds of epithelium and different tumor groups, with possible relevance to the histogenesis of the histologic subtypes of NPC.
- Published
- 1984
34. Inverted Papilloma of the Nasal Septum
- Author
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Kelly, J. H., primary, Joseph, M., additional, Carroll, E., additional, Goodman, M. L., additional, Pilch, B. Z., additional, Levinson, R. M., additional, and Strome, M., additional
- Published
- 1980
- Full Text
- View/download PDF
35. Fetal Rhabdomyoma of the Larynx
- Author
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Granich, M. S., primary, Pilch, B. Z., additional, Nadol, J. B., additional, and Dickersin, G. R., additional
- Published
- 1983
- Full Text
- View/download PDF
36. Hamartoma of the Hypopharynx
- Author
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Patterson, H. C., primary, Dickerson, G. R., additional, Pilch, B. Z., additional, and Bentkover, S. H., additional
- Published
- 1981
- Full Text
- View/download PDF
37. Effect of azomethine structural modification of electrochromic performance.
- Author
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Gautier, Yohan and Skene, W. G.
- Abstract
Towards understanding the structural requirements for extending the anodic reversibility, a series of conjugated azomethine triads end-capped with amides were prepared. The effect of a phenyl and two triphenylamine end-capping groups on the oxidation potential, electrochemical reversibility, and color were assessed. The core aromatic of the conjugated framework was also varied to include thiophene, EDOT, and two triphenylamine derivatives. With the amide end group, the anodic potential increased by 270 mV relative to the amine termini counterpart. An irreversible anodic process was observed with the unsubstituted triphenylamine end group, resulting in an electroactive film deposited on the working electrode. In contrast, desired reversible oxidation was possible with an 4,4′-dimethyltriphenylamine end-capping group. The anodically induced reversible perceived color change was from orange to violet when the central aromatic was a triphenylamine. The absorption of the oxidized intermediate was contingent on the capping-group and the central aromatic and it was upwards of 220 nm red-shifted from the neutral state. Similar spectral shifts were found with the EDOT and thiophene cores. In these cases, the red color of the intrinsic chromophore bleached upon oxidation and it was replaced with a blue color with a broad absorption at ca. 650 nm. Consistent differences in the transmittance with repeated oxidation/neutralization cycles were possible upwards of 6 hours when end-capping with the 4,4′-dimethyltriphenylamine, regardless of the aromatic core. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
38. Exploring the Potential of Bioactive Peptides: From Natural Sources to Therapeutics.
- Author
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Purohit, Kruttika, Reddy, Narsimha, and Sunna, Anwar
- Subjects
PEPTIDES ,ANTIMICROBIAL peptides ,CAPILLARY electrophoresis ,STRUCTURE-activity relationships ,LIQUID chromatography ,CAPILLARY liquid chromatography - Abstract
Bioactive peptides, specific protein fragments with positive health effects, are gaining traction in drug development for advantages like enhanced penetration, low toxicity, and rapid clearance. This comprehensive review navigates the intricate landscape of peptide science, covering discovery to functional characterization. Beginning with a peptidomic exploration of natural sources, the review emphasizes the search for novel peptides. Extraction approaches, including enzymatic hydrolysis, microbial fermentation, and specialized methods for disulfide-linked peptides, are extensively covered. Mass spectrometric analysis techniques for data acquisition and identification, such as liquid chromatography, capillary electrophoresis, untargeted peptide analysis, and bioinformatics, are thoroughly outlined. The exploration of peptide bioactivity incorporates various methodologies, from in vitro assays to in silico techniques, including advanced approaches like phage display and cell-based assays. The review also discusses the structure–activity relationship in the context of antimicrobial peptides (AMPs), ACE-inhibitory peptides (ACEs), and antioxidative peptides (AOPs). Concluding with key findings and future research directions, this interdisciplinary review serves as a comprehensive reference, offering a holistic understanding of peptides and their potential therapeutic applications. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
39. The prevalence of extra-salivary gland complications in immunoglobulin G4-related sialadenitis.
- Author
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Zhou W, Li Y, Yan C, Zheng L, Liu F, and Sun C
- Subjects
- Humans, Immunoglobulin G, Prevalence, Prospective Studies, Salivary Glands pathology, Sialadenitis epidemiology, Sialadenitis pathology
- Abstract
Objectives: To estimate the prevalence of extra-glandular lesions in patients with immunoglobulin G4-related sialadenitis (IgG4-RS)., Methods: Six electronic databases (PubMed, EMBASE, Science Direct, Scopus, Web of Science, and China National Knowledge Infrastructure) were systematically searched from the date of inception of each database to March 2021. The Strengthening the Reporting of Observational Studies in Epidemiology statement was used to conduct methodological quality assessment, and a random-effect meta-analysis model was applied to estimate the prevalence. Publication bias was visually assessed using a funnel plot and calculated via Begg's and Egger's tests. The Stata 15 software was used to perform data analysis., Results: A total of 43 articles comprising 1,864 patients with IgG4-RS were considered to be eligible for this study. The pooled prevalence of extra-salivary gland lesions in IgG4-RS was 76.53% with a confidence interval (CI) of (69.39%, 83.04%). A higher prevalence was associated with studies published before or during 2015 (84.38%, CI [74.23%, 92.58%]) than those published after 2015 (68.55%, CI [58.44%, 77.88%]). Lacrimal gland involvement (54.68%, CI [45.61%, 63.60%]) and lymph node swelling (56.96%, CI [48.16%, 65.56%]) were the most frequent lesions., Conclusions: Extra-glandular lesions were common in patients with IgG4-RS. More high-quality prospective studies with less heterogeneity are required to determine the accurate prevalence., (© 2021 Wiley Periodicals LLC.)
- Published
- 2022
- Full Text
- View/download PDF
40. Ecclesiological implications for the church as intergenerational space focusing on families.
- Author
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Mans, P. R. and Rousseau, P. A.
- Subjects
SOCIAL development ,AGE groups ,SOCIAL media ,GLOBALIZATION ,FAMILIES - Abstract
The church is God’s primary vehicle to minister in a global landscape dotted with globalisation, social media, wars, environmental issues, global economics, global social developments, and politics. Given the fact that the family is the microcosm where discipling should take place according to Psalm 78:4-7 (also Deut. 6:7-9; Matt. 28:19-20; 1 Cor. 3:4-9), this focus naturally leads to the critical question: Where do families fit in this mandate? Segregation in ministry results in divided age groups, lack of inclusiveness of all members in all of church life, and a low view of children as part of the church (Holmes et al. 2022:1-3). The article revisits a biblical framework of what church should be, in order to refresh insight into how the church could and should respond to an intergenerational understanding of the form and function of the church. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
41. The Application of Ejaculate-Based Shotgun Proteomics for Male Infertility Screening.
- Author
-
Shkrigunov, Timur, Zgoda, Victor, Klimenko, Peter, Kozlova, Anna, Klimenko, Maria, Lisitsa, Andrey, Kurtser, Mark, and Petushkova, Natalia
- Subjects
MALE infertility ,SEMINAL proteins ,MALE reproductive organs ,PROTEOMICS ,CELL anatomy - Abstract
Problems with the male reproductive system are of both medical and social significance. As a rule, spermatozoa and seminal plasma proteomes are investigated separately to assess sperm quality. The current study aimed to compare ejaculate proteomes with spermatozoa and seminal plasma protein profiles regarding the identification of proteins related to fertility scores. A total of 1779, 715, and 2163 proteins were identified in the ejaculate, seminal plasma, and spermatozoa, respectively. Among these datasets, 472 proteins were shared. GO enrichment analysis of the common proteins enabled us to distinguish biological processes such as single fertilization (GO:0007338), spermatid development (GO:0007286), and cell motility (GO:0048870). Among the abundant terms for GO cellular components, zona pellucida receptor complex, sperm fibrous sheath, and outer dense fiber were revealed. Overall, we identified 139 testis-specific proteins. For these proteins, PPI networks that are common in ejaculate, spermatozoa, and seminal plasma were related to the following GO biological processes: cilium movement (GO:0003341), microtubule-based movement (GO:0007018), and sperm motility (GO:0097722). For ejaculate and spermatozoa, they shared 15 common testis-specific proteins with spermatogenesis (GO:0007283) and male gamete generation (GO:0048232). Therefore, we speculated that ejaculate-based proteomics could yield new insights into the peculiar reproductive physiology and spermatozoa function of men and potentially serve as an explanation for male infertility screening. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
42. Is value investing based on scoring models effective? The verification of F-Score-based strategy in the Polish stock market.
- Author
-
Pilch, Bartłomiej
- Subjects
ECONOMIC entity ,INVESTORS ,STOCKS (Finance) ,INVESTMENT policy ,CREDIT scoring systems - Abstract
The aim of the paper is to analyse the effectiveness of F-Score-like models using the example of the Polish stock market. F-Score is a scoring model based on a high B/M investing strategy, which uses fundamental signals to assess the economic condition of an entity. So far, its effectiveness has been generally proven in numerous stock markets worldwide. However, no comprehensive study focusing on the Polish market has been conducted. Therefore, F-Score and similar models (FS-Score and PiotroskiTrfm) were analysed in this regard. It was shown that companies with higher scores generated positive both raw and market-adjusted returns on average. However, they were lower than the mean returns of low-score companies (for FS-Score) or total high B/M portfolio (regarding F-Score and PiotroskiTrfm). The results of the study show that F-Score, FS-Score and PiotroskiTrfm are generally effective investing tools. However, it might be more advisable for value investors to choose a total high B/M portfolio instead of shares of high-score entities according to F-Score or PiotroskiTrfm. [ABSTRACT FROM AUTHOR]
- Published
- 2023
- Full Text
- View/download PDF
43. Does Rainbow Trout Seminal Plasma-Cysteine Combination Affect the Cryo-Survivability and Post-Thaw Incubation Resilience of Ram Semen?
- Author
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Gökçe, Elif and Üstüner, Burcu
- Published
- 2023
- Full Text
- View/download PDF
44. The effect of seminal fluid gene expression on paternity.
- Author
-
Simmons, Leigh W. and Lovegrove, Maxine
- Subjects
SPERM competition ,GENE expression ,SMALL interfering RNA ,SEMINAL proteins ,RNA interference ,PATERNITY ,SPERMATOZOA - Abstract
When females mate with more than one male, competition between rival ejaculates is expected to favor adaptations that promote fertilization success. There is now compelling evidence that sperm competition selects for increased production and allocation of sperm. However, sperm comes packaged in ejaculates that also contain protein-rich seminal fluids. Predicting how males should allocate individual seminal fluid proteins in response to sperm competition is hampered by our limited knowledge of their precise function. We use gene expression studies and interference RNA to ask how seminal fluid proteins in the ejaculate of a cricket, Teleogryllus oceanicus, affect a male's paternity share when in competition for fertilizations. We find that the relative expression of one seminal fluid gene, gagein, positively affects the paternity share of competing males and that knockdown of this and two other seminal fluid protein genes renders males mating in the offensive role of sperm competition incapable of fathering living offspring. Despite having a negative effect on offspring viability these seminal fluid genes have been found to be up regulated in response to rival males, consistent with a role in promoting competitive fertilization success. Our data contribute to a growing body of evidence that, like sperm, seminal fluid gene expression is subject to post-mating sexual selection via sperm competition. [ABSTRACT FROM AUTHOR]
- Published
- 2023
- Full Text
- View/download PDF
45. Diffuse Large B-Cell Lymphoma of the Frontal Sinus: A Case Report.
- Author
-
Urbanelli, Anastasia, Testi, Francesca, Riva, Giuseppe, and Pecorari, Giancarlo
- Subjects
FRONTAL sinus ,DIFFUSE large B-cell lymphomas ,PARANASAL sinuses ,NASAL cavity ,GASTROINTESTINAL system ,NON-Hodgkin's lymphoma - Abstract
Diffuse large B-cell lymphoma (DLBCL) is the most common type of Non-Hodgkin Lymphoma (NHL). It often involves the gastrointestinal tract, head and neck, and skin, but virtually any tissue or organ can be affected. The primary NHL of the nasal cavity and paranasal sinuses are extremely rare, causing diagnostic and therapeutic difficulties. We present the case of a 49-year-old woman with a 4-week history of diplopia and right superior eyelid swelling. Clinical, radiological, and histological examination led to the diagnosis of DLBCL of the right frontal sinus with anterior invasion of subcutaneous soft tissues and posterior intracranial involvement of the frontal region. She underwent three cycles of MATRIX chemotherapy, three cycles of R-DA-EPOCH, and CAR-T therapy. Unfortunately, treatments were unsuccessful and the patient died 11 months after diagnosis. In conclusion, an early diagnosis of DLBCL of the frontal sinus is difficult as it is often confused with other nasal pathologies. This causes a delay in treatment. [ABSTRACT FROM AUTHOR]
- Published
- 2023
- Full Text
- View/download PDF
46. Non-Invasive Diagnostics of Male Spermatogenesis from Seminal Plasma: Seminal Proteins.
- Author
-
Ješeta, Michal, Pospíšilová, Anna, Mekiňová, Lenka, Franzová, Kateřina, Ventruba, Pavel, Lousová, Eva, Kempisty, Bartosz, Oždian, Tomáš, Žáková, Jana, and Crha, Igor
- Subjects
SEMINAL proteins ,MALE infertility ,AZOOSPERMIA ,SPERMATOGENESIS ,FERTILITY - Abstract
The compounds of seminal plasma have great potential as biomarkers of male fertility and can be used as a diagnostic tool for types of azoospermia. Azoospermia occurs in approximately 1% of the male population, and for an effective therapy of this form of male infertility, it is important to distinguish between obstructive and non-obstructive azoospermia. Proteins in seminal plasma can serve as biomarkers for diagnosing azoospermia. Considering the various types of obstructions, a combination of multiple proteins is advisable for diagnostic purposes. In this context, testicular and epididymal proteins are particularly significant, as they are specific to these tissues and typically absent in ejaculate during most obstructions. A combination of multiple biomarkers is more effective than the analysis of a single protein. This group of markers contains TEX101 and ECM1 proteins, combined detections of these two bring a diagnostic output with a high sensitivity and specificity. Similar results were observed for combined detection of TEX101 and SPAG1. The effective using of specific biomarkers from seminal plasma can significantly improve the existing approaches to diagnosis of the causes of male infertility. [ABSTRACT FROM AUTHOR]
- Published
- 2023
- Full Text
- View/download PDF
47. Characterization of ectopic germinal centers in Sjögren's syndrome (SS) and non-SS non-sicca patients.
- Author
-
Silva EV, de Andrade BAB, Silveira HA, Rocha EM, Chahud F, Brunaldi MO, Bufalino A, and León JE
- Subjects
- Humans, Female, Middle Aged, Male, Choristoma pathology, Adult, Sjogren's Syndrome complications, Germinal Center pathology
- Published
- 2024
- Full Text
- View/download PDF
48. CXCL8, MMP1, MMP2, and FN1 Gene Expression and Tumor Extension in Nasopharyngeal Cancer Patients: A Cross-sectional Study.
- Author
-
Rahmat Cahyanur, Cosphiadi Irawan, Lisnawati lisnawati, Marlinda Adham, Achmad Fauzi Kamal, Ahmad Rusdan Handoyo Utomo, Mardiah Suci Hardianti, Muchtaruddin Mansyur, and Thariqah Salamah
- Published
- 2023
49. EFFECTS OF MARKETING COMMUNICATION OF A SMALL SERVICE COMPANY ON INSTAGRAM.
- Author
-
Rudzewicz, Adam
- Subjects
INTERNET marketing ,SERVICE industries ,SOCIAL media ,BLOGS - Abstract
Copyright of Olsztyn Economic Journal is the property of Olsztyn Economic Journal and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2023
- Full Text
- View/download PDF
50. What a Neurosurgeon Should Know About the Endolymphatic Sac: Part 2 – Diagnosis and Management of the Endolymphatic Sac Tumors.
- Author
-
Vaz, Marco Antônio Schlindwein, Moreira Monteiro, Jander, Braga, Francisco Luiz Souza, Lavinsky, Joel, Santis, Giuseppe Casella, Dini, Leandro Infantini, da Rocha Filho, Marcelo Assis Moro, Ribas, Carmen Austrália Paredes Marcondes, de Araújo, Ricardo Marques Lopes, Figueiredo, Eberval Gadelha, and Isolan, Gustavo Rassier
- Published
- 2023
- Full Text
- View/download PDF
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