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19 results on '"Perkasa, Aditya"'

1. CoPoP liposomes displaying stabilized clade C HIV-1 Env elicit tier 2 multiclade neutralization in rabbits

Author

Koornneef, Annemart, Vanshylla, Kanika, Hardenberg, Gijs, Rutten, Lucy, Strokappe, Nika M., Tolboom, Jeroen, Vreugdenhil, Jessica, Boer, Karin Feddes-de, Perkasa, Aditya, Blokland, Sven, Burger, Judith A., Huang, Wei-Chiao, Lovell, Jonathan F., van Manen, Danielle, Sanders, Rogier W., Zahn, Roland C., Schuitemaker, Hanneke, Langedijk, Johannes P. M., and Wegmann, Frank

Published
2024
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2. Booster vaccination with Ad26.COV2.S or an Omicron-adapted vaccine in pre-immune hamsters protects against Omicron BA.2

Author

Swart, Maarten, van der Lubbe, Joan, Schmit-Tillemans, Sonja, van Huizen, Ella, Verspuij, Johan, Gil, Ana Izquierdo, Choi, Ying, Daal, Chenandly, Perkasa, Aditya, de Wilde, Adriaan, Claassen, Erwin, de Jong, Rineke, Wiese, Katrin E., Cornelissen, Lisette, van Es, Marieke, van Heerden, Marjolein, Kourkouta, Eleni, Tahiri, Issam, Mulders, Michel, Vreugdenhil, Jessica, Feddes - de Boer, Karin, Muchene, Leacky, Tolboom, Jeroen, Dekking, Liesbeth, Juraszek, Jarek, Vellinga, Jort, Custers, Jerome, Bos, Rinke, Schuitemaker, Hanneke, Wegmann, Frank, Roozendaal, Ramon, Kuipers, Harmjan, and Zahn, Roland

Published
2023
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3. Impact of SARS-CoV-2 spike stability and RBD exposure on antigenicity and immunogenicity

Author

Rutten, Lucy, primary, Swart, Maarten, additional, Koornneef, Annemart, additional, Bouchier, Pascale, additional, Blokland, Sven, additional, Sadi, Ava, additional, Juraszek, Jarek, additional, Vijayan, Aneesh, additional, Schmit-Tillemans, Sonja, additional, Verspuij, Johan, additional, Choi, Ying, additional, Daal, Chenandly E., additional, Perkasa, Aditya, additional, Torres Morales, Shessy, additional, Myeni, Sebenzile K., additional, Kikkert, Marjolein, additional, Tolboom, Jeroen, additional, van Manen, Daniëlle, additional, Kuipers, Harmjan, additional, Schuitemaker, Hanneke, additional, Zahn, Roland, additional, and Langedijk, Johannes P. M., additional

Published
2024
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4. Characterization of reverse-engineered anti-PF4 stereotypic antibodies derived from serum of patients with VITT

Author

Wang, Jing Jing, primary, van der Neut Kolfschoten, Marijn, additional, Rutten, Lucy, additional, Armour, Bridie, additional, Tan, Chee Wee, additional, Chataway, Tim, additional, Bos, Rinke, additional, Koornneef, Annemart, additional, Abeywickrema, Pravien, additional, Kapur, Rick, additional, Porcelijn, Leendert, additional, Khalifa, Midia, additional, Sadi, Ava, additional, Bouchier, Pascale, additional, Kourkouta, Eleni, additional, Perkasa, Aditya, additional, Kwaks, Ted, additional, Zahn, Roland, additional, Solforosi, Laura, additional, and Gordon, Tom P., additional

Published
2024
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5. Mycoplasma pneumoniae carriage evades induction of protective mucosal antibodies

Author

de Groot, Ruben Cornelis Anthonie; https://orcid.org/0000-0002-5071-2781, Cristina Estevão, Silvia, Meyer Sauteur, Patrick Michael; https://orcid.org/0000-0002-4312-9803, Perkasa, Aditya, Hoogenboezem, Theo, Spuesens, Emiel Benny Margriet, Verhagen, Lilly Maria, van Rossum, Anna Maria Christiane, Unger, Wendy Wilhelmina Josephina, de Groot, Ruben Cornelis Anthonie; https://orcid.org/0000-0002-5071-2781, Cristina Estevão, Silvia, Meyer Sauteur, Patrick Michael; https://orcid.org/0000-0002-4312-9803, Perkasa, Aditya, Hoogenboezem, Theo, Spuesens, Emiel Benny Margriet, Verhagen, Lilly Maria, van Rossum, Anna Maria Christiane, and Unger, Wendy Wilhelmina Josephina

Abstract

Mycoplasma pneumoniae is the most common bacterial cause of pneumonia in children hospitalised for community-acquired pneumonia. Prevention of infection by vaccines may be an important strategy in the presence of emerging macrolide resistant M. pneumoniae. However, knowledge of immune responses to M. pneumoniae is limited, complicating vaccine design. We therefore studied the antibody response during M. pneumoniae infection and asymptomatic carriage.In a nested case-control study (n=80) of M. pneumoniae carriers and matched controls we observed that carriage by M. pneumoniae does not lead to a rise in either mucosal or systemic M. pneumoniae-specific antibodies, even after months of persistent carriage. We replicated this finding in a second cohort (n=69) and also found that during M. pneumoniae community-acquired pneumonia, mucosal levels of M. pneumoniae-specific IgA and IgG did increase significantly. In vitro adhesion assays revealed that high levels of M. pneumoniae-specific antibodies in nasal secretions of paediatric patients prevented the adhesion of M. pneumoniae to respiratory epithelial cells.In conclusion, our study demonstrates that M. pneumoniae-specific mucosal antibodies protect against bacterial adhesion to respiratory epithelial cells and are induced only during M. pneumoniae infection and not during asymptomatic carriage. This is strikingly different from carriage with bacteria such as Streptococcus pneumoniae where mucosal antibodies are induced by bacterial carriage.

Published
2022

7. Characterization of reverse-engineered anti-PF4 stereotypic antibodies derived from serum of patients with VITT

Author

Wang, Jing Jing, van der Neut Kolfschoten, Marijn, Rutten, Lucy, Armour, Bridie, Tan, Chee Wee, Chataway, Tim, Bos, Rinke, Koornneef, Annemart, Abeywickrema, Pravien, Kapur, Rick, Porcelijn, Leendert, Khalifa, Midia, Sadi, Ava, Bouchier, Pascale, Kourkouta, Eleni, Perkasa, Aditya, Kwaks, Ted, Zahn, Roland, Solforosi, Laura, and Gordon, Tom P.

Published
2023
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8. Hypnozoite depletion in successive Plasmodium vivax relapses

Author

Noviyanti, Rintis, primary, Carey-Ewend, Kelly, additional, Trianty, Leily, additional, Parobek, Christian, additional, Puspitasari, Agatha Mia, additional, Balasubramanian, Sujata, additional, Park, Zackary, additional, Hathaway, Nicholas, additional, Utami, Retno A. S., additional, Soebianto, Saraswati, additional, Jeny, Jeny, additional, Yudhaputri, Frilasita, additional, Perkasa, Aditya, additional, Coutrier, Farah N., additional, Tirta, Yusrifar K., additional, Ekawati, Lenny, additional, Tjahyono, Bagus, additional, Sutanto, Inge, additional, Nelwan, Erni J., additional, Sudoyo, Herawati, additional, Baird, J. Kevin, additional, and Lin, Jessica T., additional

Published
2022
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9. Mycoplasma pneumoniae carriage evades induction of protective mucosal antibodies

Author

De Groot, Ruben Cornelis Anthonie, Estevao, Silvia Cristina, Sauteur, Patrick Michael Meyer, Perkasa, Aditya, Hoogenboezem, Theo, Spuesens, Emiel Benny Margriet, Verhagen, Lilly Maria, Van Rossum, Anna Maria Christiane, Unger, Wendy Wilhelmina Josephina, De Groot, Ruben Cornelis Anthonie, Estevao, Silvia Cristina, Sauteur, Patrick Michael Meyer, Perkasa, Aditya, Hoogenboezem, Theo, Spuesens, Emiel Benny Margriet, Verhagen, Lilly Maria, Van Rossum, Anna Maria Christiane, and Unger, Wendy Wilhelmina Josephina

Abstract

Background Mycoplasma pneumoniae is the most common bacterial cause of pneumonia in children hospitalised for community-acquired pneumonia (CAP). Prevention of infection by vaccines may be an important strategy in the presence of emerging macrolide-resistant M. pneumoniae. However, knowledge of immune responses to M. pneumoniae is limited, complicating vaccine design. Methods We studied the antibody response during M. pneumoniae respiratory tract infection and asymptomatic carriage in two different cohorts. Results In a nested case-control study (n=80) of M. pneumoniae carriers and matched controls we observed that carriage by M. pneumoniae does not lead to a rise in either mucosal or systemic M. pneumoniae-specific antibodies, even after months of persistent carriage. We replicated this finding in a second cohort (n=69) and also found that during M. pneumoniae CAP, mucosal levels of M. pneumoniaespecific IgA and IgG did increase significantly. In vitro adhesion assays revealed that high levels of M. pneumoniae-specific antibodies in nasal secretions of paediatric patients prevented the adhesion of M. pneumoniae to respiratory epithelial cells. Conclusions Our study demonstrates that M. pneumoniae-specific mucosal antibodies protect against bacterial adhesion to respiratory epithelial cells, and are induced only during M. pneumoniae infection and not during asymptomatic carriage. This is strikingly different from carriage with bacteria such as Streptococcus pneumoniae where mucosal antibodies are induced by bacterial carriage.

Published
2022

10. Immunogenicity of an Ad26-based SARS-CoV-2 Omicron Vaccine in Naïve Mice and SARS-CoV-2 Spike Pre-immune Hamsters

Author

Swart, Maarten, primary, de Wilde, Adriaan, additional, Schmit-Tillemans, Sonja, additional, Verspuij, Johan, additional, Daal, Chenandly, additional, Choi, Ying, additional, Perkasa, Aditya, additional, Kourkouta, Eleni, additional, Tahiri, Issam, additional, Mulders, Michel, additional, Gil, Ana Izquierdo, additional, Muchene, Leacky, additional, Juraszek, Jarek, additional, Vellinga, Jort, additional, Custers, Jerome, additional, Bos, Rinke, additional, Schuitemaker, Hanneke, additional, Wegmann, Frank, additional, Roozendaal, Ramon, additional, Kuipers, Harmjan, additional, and Zahn, Roland, additional

Published
2022
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11. Mycoplasma pneumoniae carriage evades induction of protective mucosal antibodies

Author

de Groot, Ruben Cornelis Anthonie, primary, Cristina Estevão, Silvia, additional, Meyer Sauteur, Patrick Michael, additional, Perkasa, Aditya, additional, Hoogenboezem, Theo, additional, Spuesens, Emiel Benny Margriet, additional, Verhagen, Lilly Maria, additional, van Rossum, Anna Maria Christiane, additional, and Unger, Wendy Wilhelmina Josephina, additional

Published
2021
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12. Isolation of Zika virus from febrile patient, Indonesia

Author

Perkasa, Aditya, Yudhaputri, Frilasita, Haryanto, Sotianingsih, Hayati, Rahma F., Maroef, Chairin Nisa, Antonjaya, Ungke, Yohan, Benediktus, Myint, Khin Saw Aye, Ledermann, Jeremy P., Rosenberg, Ronald, Powers, Ann M., and Sasmono, R. Tedjo

Subjects
Health
Abstract

To the Editor: Arthropodborne viruses (arboviruses) cause substantial human disease worldwide and have a pronounced effect on public health throughout Asia. Zika virus, discovered in Uganda in 1947 (1), is [...]

Published
2016

13. Isolation and complete genome analysis of neurotropic dengue virus serotype 3 from the cerebrospinal fluid of an encephalitis patient

Author

Dhenni, Rama, primary, Karyanti, Mulya Rahma, additional, Putri, Nina Dwi, additional, Yohan, Benediktus, additional, Yudhaputri, Frilasita A., additional, Ma'roef, Chairin Nisa, additional, Fadhilah, Araniy, additional, Perkasa, Aditya, additional, Restuadi, Restuadi, additional, Trimarsanto, Hidayat, additional, Mangunatmadja, Irawan, additional, Ledermann, Jeremy P., additional, Rosenberg, Ronald, additional, Powers, Ann M., additional, Myint, Khin Saw Aye, additional, and Sasmono, R. Tedjo, additional

Published
2018
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15. Genomic characterization of Zika virus isolated from Indonesia

Author

Yudhaputri, Frilasita A., primary, Trimarsanto, Hidayat, additional, Perkasa, Aditya, additional, Yohan, Benediktus, additional, Haryanto, Sotianingsih, additional, Wiyatno, Ageng, additional, Soebandrio, Amin, additional, Myint, Khin Saw, additional, Ledermann, Jeremy P., additional, Rosenberg, Ronald, additional, Powers, Ann M., additional, and Sasmono, R. Tedjo, additional

Published
2017
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16. Chikungunya fever outbreak identified in North Bali, Indonesia

Author

Sari, Kartika, primary, Myint, Khin Saw Aye, additional, Andayani, Ayu Rai, additional, Adi, Putu Dwi, additional, Dhenni, Rama, additional, Perkasa, Aditya, additional, Ma'roef, Chairin Nisa, additional, Witari, Ni Putu Diah, additional, Megawati, Dewi, additional, Powers, Ann M, additional, and Jaya, Ungke Anton, additional

Published
2017
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19. Knowledge and attitude towards pregnancy-related issues of Zika virus infection among general practitioners in Indonesia.

Author

Harapan, Harapan, Rajamoorthy, Yogambigai, Utomo, Prattama S., Anwar, Samsul, Setiawan, Abdul M., Alleta, Alma, Bambang, Alfredo, Ramadana, Muhammad R., Ikram, Ikram, Wahyuniati, Nur, Maulana, Reza, Ichsan, Ichsan, Indah, Rosaria, Wagner, Abram L., Kuch, Ulrich, Groneberg, David A., Rodríguez-Morales, Alfonso J., Andalas, Mohd, Müller, Ruth, and Mudatsir, Mudatsir

Subjects
ZIKA virus infections, GENERAL practitioners, CAREER development, ZIKA virus, MULTIVARIATE analysis
Abstract

Background: The aim of this study was to assess the knowledge and attitudes towards pregnancy-related issues of Zika virus (ZIKV) infection among general practitioners (GPs), a frontline healthcare worker group, in Indonesia.Methods: A cross-sectional, online survey assessing knowledge and attitudes towards ZIKV infection on multiple-item scales was sent to GPs in the Sumatra and Java islands of Indonesia. The associations between independent factors and either knowledge or attitude were assessed with logistic regressions. The correlation and association between knowledge and attitude were estimated.Results: We included 457 (53.7%) out of 850 responses in the analysis. Among these, 304 (66.5%) and 111 (24.2%) respondents had a good knowledge and attitude, respectively. No demographic, workplace, professional development, or experiential characteristics related to ZIKV infection were associated with knowledge. In the multivariate analysis, only contact experience was associated with attitude. There was a significant, positive correlation between knowledge and attitude scores.Conclusions: Although knowledge of pregnancy-related complications of ZIKV infection is relatively high among GPs in Indonesia, more than 75% of them had a poor attitude towards pregnancy-related issues of Zika. Strategies for enhancing the capacity of GPs to develop positive attitudes and respond to ZIKV infection are needed. [ABSTRACT FROM AUTHOR]

Published
2019
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