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1. On the Need for Analytical Pedagogy in Poland. A review of a monograph by Alicja Żywczok and Bogumiła Bobik, Pedagogika analityczna. Od porządkowania wiedzy naukowej do odkrywania jej nowych obszarów [Analytical Pedagogy: From Organizing Scientific Knowledge to Discovering New Domains] Katowice: Wydawnictwo Uniwersytetu Śląskiego, 2022, ss. 156, ISBN 978-83-226-4240-5

Author: Dariusz Stępkowski
Subjects: Education
Abstract: The reviewed monograph presents the concept of analytical pedagogy as a new sub-discipline in the landscape of Polish scholarship on education. Its subject is intellectual pursuits consisting in categorizing, typologizing and systematizing concepts relevant to education professionals. The epistemic potential of philosophical logic provides the grounds for ordering our knowledge and thus a better handling of academic and educational work, but also discovering new and so far unexplored areas of cognition. Despite Poland’s noteworthy heritage of analytical research, such a sub-discipline is still lacking in the science(s) of education. ABSTRAKT W recenzowanej monografii zaprezentowano koncepcję pedagogiki analitycznej jako nowej subdyscypliny w polskiej pedagogice akademickiej. Jej przedmiotem są czynności intelektualne polegające na kategoryzowaniu, typologizowaniu i systematyzowaniu pojęć specjalistycznych. Epistemiczny potencjał logiki filozoficznej sprawia, że czynności te umożliwiają uporządkowanie wiedzy, a przez to lepsze posługiwanie się nią w działalności naukowej i edukacyjnej, jak również odkrywanie nieoznaczonych do tej pory obszarów poznania. Pomimo dziedzictwa przeszłości w zakresie prowadzenia badań analitycznych wciąż brakuje w polskiej pedagogice takiej subdyscypliny.
Published: 2023
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2. EUSO-SPB1 Mission and Science

Author: Collaboration, JEM-EUSO, Abdellaoui, G., Abe, S., Adams. Jr., J. H., Allard, D., Alonso, G., Anchordoqui, L., Anzalone, A., Arnone, E., Asano, K., Attallah, R., Attoui, H., Pernas, M. Ave, Bachmann, R., Bacholle, S., Bagheri, M., Bakiri, M., Baláz, J., Barghini, D., Bartocci, S., Battisti, M., Bayer, J., Beldjilali, B., Belenguer, T., Belkhalfa, N., Bellotti, R., Belov, A. A., Benmessai, K., Bertaina, M., Bertone, P. F., Biermann, P. L., Bisconti, F., Blaksley, C., Blanc, N., Blin-Bondil, S., Bobik, P., Bogomilov, M., Bolmgren, K., Bozzo, E., Briz, S., Bruno, A., Caballero, K. S., Cafagna, F., Cambié, G., Campana, D., Capdevielle, J. N., Capel, F., Caramete, A., Caramete, L., Caruso, R., Casolino, M., Cassardo, C., Castellina, A., Catalano, O., Cellino, A., Černý, K., Chikawa, M., Chiritoi, G., Christl, M. J., Colalillo, R., Conti, L., Cotto, G., Crawford, H. J., Cremonini, R., Creusot, A., Cummings, A., Gónzalez, A. de Castro, de la Taille, C., del Peral, L., Desiato, J., Damian, A. Diaz, Diesing, R., Dinaucourt, P., Djakonow, A., Djemil, T., Ebersoldt, A., Ebisuzaki, T., Eser, J., Fenu, F., Fernández-González, S., Ferrarese, S., Filippatos, G., Finch, W., Fornaro, C., Fouka, M., Franceschi, A., Franchini, S., Fuglesang, C., Fujii, T., Fukushima, M., Galeotti, P., García-Ortega, E., Gardiol, D., Garipov, G. K., Gascón, E., Gazda, E., Genci, J., Golzio, A., Gorodetzky, P., Gregg, R., Green, A., Guarino, F., Guépin, C., Guzmán, A., Hachisu, Y., Haungs, A., Heigbes, T., Carretero, J. Hernández, Hulett, L., Ikeda, D., Inoue, N., Inoue, S., Isgrò, F., Itow, Y., Jammer, T., Jeong, S., Jochum, J., Joven, E., Judd, E. G., Jung, A., Kajino, F., Kajino, T., Kalli, S., Kaneko, I., Kasztelan, M., Katahira, K., Kawai, K., Kawasaki, Y., Kedadra, A., Khales, H., Khrenov, B. A., Kim, Jeong-Sook, Kim, Soon-Wook, Kleifges, M., Klimov, P. A., Kreykenbohm, I., Krizmanic, J. F., Królik, K., Kungel, V., Kurihara, Y., Kusenko, A., Kuznetsov, E., Lahmar, H., Lakhdari, F., Licandro, J., Campano, L. López, Martínez, F. López, Mackovjak, S., Mahdi, M., Mandát, D., Manfrin, M., Marcelli, L., Marcos, J. L., Marszał, W., Martín, Y., Martinez, O., Mase, K., Mastafa, M., Matthews, J. N., Mebarki, N., Medina-Tanco, G., Menshikov, A., Merino, A., Mese, M., Meseguer, J., Meyer, S. S., Mimouni, J., Miyamoto, H., Mizumoto, Y., Monaco, A., Ríos, J. A. Morales de los, Nachtman, J. M., Nagataki, S., Naitamor, S., Napolitano, T., Neronov, A., Nomoto, K., Nonaka, T., Ogawa, T., Ogio, S., Ohmori, H., Olinto, A. V., Onel, Y., Osteria, G., Otte, A. N., Pagliaro, A., Painter, W., Panasyuk, M. I., Panico, B., Parizot, E., Park, I. H., Pastircak, B., Paul, T., Pech, M., Pérez-Grande, I., Perfetto, F., Peter, T., Picozza, P., Pindado, S., Piotrowski, L. W., Piraino, S., Plebaniak, Z., Pollini, A., Popescu, E. M., Prevete, R., Prévôt, G., Prieto, H., Przybylak, M., Puehlhofer, G., Putis, M., Reardon, P., Reno, M. H., Reyes, M., Ricci, M., Frías, M. D. Rodríguez, Matamala, O. F. Romero, Ronga, F., Sabau, M. D., Saccá, G., Sagawa, H., Sahnoune, Z., Saito, A., Sakaki, N., Salazar, H., Sánchez, J. L., Balanzar, J. C. Sanchez, Santangelo, A., Sanz-Andrés, A., Saprykin, O. A., Sarazin, F., Sato, M., Scagliola, A., Schanz, T., Schieler, H., Schovánek, P., Scotti, V., Serra, M., Sharakin, S. A., Shimizu, H. M., Shinozaki, K., Soriano, J. F., Sotgiu, A., Stan, I., Strharský, I., Sugiyama, N., Supanitsky, D., Suzuki, M., Szabelski, J., Tajima, N., Tajima, T., Takahashi, Y., Takeda, M., Takizawa, Y., Talai, M. C., Tameda, Y., Tenzer, C., Thomas, S. B., Tibolla, O., Tkachev, L. G., Tomida, T., Tone, N., Toscano, S., Traïche, M., Tsunesada, Y., Tsuno, K., Turriziani, S., Uchihori, Y., Valdés-Galicia, J. F., Vallania, P., Valore, L., Vankova-Kirilova, G., Venters, T. M., Vigorito, C., Villaseñor, L., Vlcek, B., von Ballmoos, P., Vrabel, M., Wada, S., Watanabe, J., Watts. Jr., J., Muñoz, R. Weigand, Weindl, A., Wiencke, L., Wille, M., Wilms, J., Yamamoto, T., Yang, J., Yano, H., Yashin, I. V., Yonetoku, D., Yoshida, S., Young, R., Zgura, I. S., Zotov, M. Yu., and Marchi, A. Zuccaro
Subjects: Astrophysics - Instrumentation and Methods for Astrophysics, Astrophysics - High Energy Astrophysical Phenomena
Abstract: The Extreme Universe Space Observatory on a Super Pressure Balloon 1 (EUSO-SPB1) was launched in 2017 April from Wanaka, New Zealand. The plan of this mission of opportunity on a NASA super pressure balloon test flight was to circle the southern hemisphere. The primary scientific goal was to make the first observations of ultra-high-energy cosmic-ray extensive air showers (EASs) by looking down on the atmosphere with an ultraviolet (UV) fluorescence telescope from suborbital altitude (33~km). After 12~days and 4~hours aloft, the flight was terminated prematurely in the Pacific Ocean. Before the flight, the instrument was tested extensively in the West Desert of Utah, USA, with UV point sources and lasers. The test results indicated that the instrument had sensitivity to EASs of approximately 3 EeV. Simulations of the telescope system, telescope on time, and realized flight trajectory predicted an observation of about 1 event assuming clear sky conditions. The effects of high clouds were estimated to reduce this value by approximately a factor of 2. A manual search and a machine-learning-based search did not find any EAS signals in these data. Here we review the EUSO-SPB1 instrument and flight and the EAS search., Comment: 18 pages, 19 figures
Published: 2024
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3. Developments and results in the context of the JEM-EUSO program obtained with the ESAF Simulation and Analysis Framework

Author: Abe, S., Adams Jr., J. H., Allard, D., Alldredge, P., Anchordoqui, L., Anzalone, A., Arnone, E., Baret, B., Barghini, D., Battisti, M., Bayer, J., Bellotti, R., Belov, A. A., Bertaina, M., Bertone, P. F., Bianciotto, M., Biermann, P. L., Bisconti, F., Blaksley, C., Blin-Bondil, S., Bobik, P., Bolmgren, K., Briz, S., Burton, J., Cafagna, F., Cambié, G., Campana, D., Capel, F., Caruso, R., Casolino, M., Cassardo, C., Castellina, A., Černý, K., Christl, M. J., Colalillo, R., Conti, L., Cotto, G., Crawford, H. J., Cremonini, R., Creusot, A., Cummings, A., Gónzalez, A. de Castro, de la Taille, C., del Peral, L., Diesing, R., Dinaucourt, P., Di Nola, A., Ebersoldt, A., Ebisuzaki, T., Eser, J., Fenu, F., Ferrarese, S., Filippatos, G., Finch, W. W., Flaminio, F., Fornaro, C., Fuehne, D., Fuglesang, C., Fukushima, M., Gardiol, D., Garipov, G. K., Golzio, A., Gorodetzky, P., Guarino, F., Guépin, C., Guzmán, A., Haungs, A., Heibges, T., Hernández-Carretero, J., Isgrò, F., Judd, E. G., Kajino, F., Kaneko, I., Kawasaki, Y., Kleifges, M., Klimov, P. A., Kreykenbohm, I., Krizmanic, J. F., Kungel, V., Kuznetsov, E., Martínez, F. López, Mackovjak, S., Mandát, D., Manfrin, M., Marcelli, A., Marcelli, L., Marszał, W., Matthews, J. N., Menshikov, A., Mernik, T., Mese, M., Meyer, S. S., Mimouni, J., Miyamoto, H., Mizumoto, Y., Monaco, A., Ríos, J. A Morales de los, Nagataki, S., Nachtman, J. M., Naumov, D., Neronov, A., Nonaka, T., Ogawa, T., Ogio, S., Ohmori, H., Olinto, A. V., Onel, Y., Osteria, G., Pagliaro, A., Panico, B., Parizot, E., Park, I. H., Pastircak, B., Paul, T., Pech, M., Perfetto, F., Picozza, P., Piotrowski, L. W., Plebaniak, Z., Posligua, J., Prevete, R., Prévôt, G., Prieto, H., Przybylak, M., Putis, M., Reali, E., Reardon, P., Reno, M. H., Ricci, M., Frías, M. Rodríguez, Romoli, G., Cano, G. Sáez, Sagawa, H., Sakaki, N., Santangelo, A., Saprykin, O. A., Sarazin, F., Sato, M., Schieler, H., Schovánek, P., Scotti, V., Selmane, S., Sharakin, S. A., Shinozaki, K., Soriano, J. F., Szabelski, J., Tajima, N., Tajima, T., Takahashi, Y., Takeda, M., Takizawa, Y., Tenzer, C., Thomas, S. B., Tkachev, L. G., Tomida, T., Toscano, S., Traïche, M., Trofimov, D., Tsuno, K., Vallania, P., Valore, L., Venters, T. M., Vigorito, C., von Ballmoos, P., Vrabel, M., Wada, S., Watts Jr., J., Weindl, A., Wiencke, L., Wilms, J., Winn, D., Wistrand, H., Yashin, I. V., Young, R., and Zotov, M. Yu.
Subjects: Astrophysics - Instrumentation and Methods for Astrophysics, High Energy Physics - Experiment
Abstract: JEM--EUSO is an international program for the development of space-based Ultra-High Energy Cosmic Ray observatories. The program consists of a series of missions which are either under development or in the data analysis phase. All instruments are based on a wide-field-of-view telescope, which operates in the near-UV range, designed to detect the fluorescence light emitted by extensive air showers in the atmosphere. We describe the simulation software ESAFin the framework of the JEM--EUSO program and explain the physical assumptions used. We present here the implementation of the JEM--EUSO, POEMMA, K--EUSO, TUS, Mini--EUSO, EUSO--SPB1 and EUSO--TA configurations in ESAF. For the first time ESAF simulation outputs are compared with experimental data.
Published: 2023
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4. Two-dimensional high-throughput on-cell screening of immunoglobulins against broad antigen repertoires

Author: Lomakin, Yakov A., Ovchinnikova, Leyla A., Terekhov, Stanislav S., Dzhelad, Samir S., Yaroshevich, Igor, Mamedov, Ilgar, Smirnova, Anastasia, Grigoreva, Tatiana, Eliseev, Igor E., Filimonova, Ioanna N., Mokrushina, Yuliana A., Abrikosova, Victoria, Rubtsova, Maria P., Kostin, Nikita N., Simonova, Maria A., Bobik, Tatiana V., Aleshenko, Natalia L., Alekhin, Alexander I., Boitsov, Vitali M., Zhang, Hongkai, Smirnov, Ivan V., Rubtsov, Yuri P., and Gabibov, Alexander G.
Published: 2024
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5. Two-dimensional high-throughput on-cell screening of immunoglobulins against broad antigen repertoires

Author: Yakov A. Lomakin, Leyla A. Ovchinnikova, Stanislav S. Terekhov, Samir S. Dzhelad, Igor Yaroshevich, Ilgar Mamedov, Anastasia Smirnova, Tatiana Grigoreva, Igor E. Eliseev, Ioanna N. Filimonova, Yuliana A. Mokrushina, Victoria Abrikosova, Maria P. Rubtsova, Nikita N. Kostin, Maria A. Simonova, Tatiana V. Bobik, Natalia L. Aleshenko, Alexander I. Alekhin, Vitali M. Boitsov, Hongkai Zhang, Ivan V. Smirnov, Yuri P. Rubtsov, and Alexander G. Gabibov
Subjects: Biology (General), QH301-705.5
Abstract: Abstract Identifying high-affinity antibodies in human serum is challenging due to extremely low number of circulating B cells specific to the desired antigens. Delays caused by a lack of information on the immunogenic proteins of viral origin hamper the development of therapeutic antibodies. We propose an efficient approach allowing for enrichment of high-affinity antibodies against pathogen proteins with simultaneous epitope mapping, even in the absence of structural information about the pathogenic immunogens. To screen therapeutic antibodies from blood of recovered donors, only pathogen transcriptome is required to design an antigen polypeptide library, representing pathogen proteins, exposed on the bacteriophage surface. We developed a two-dimensional screening approach enriching lentiviral immunoglobulin libraries from the convalescent or vaccinated donors against bacteriophage library expressing the overlapping set of polypeptides covering the spike protein of SARS-CoV-2. This platform is suitable for pathogen-specific immunoglobulin enrichment and allows high-throughput selection of therapeutic human antibodies.
Published: 2024
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6. Immunoliposomes As a Promising Antiviral Agent against SARS-CoV-2

Author: Bobik, T. V., Simonova, M. A., Rushkevich, N. U., Kostin, N. N., Skryabin, G. A., Knorre, V. D., Schulga, A. A., Konovalova, E. V., Proshkina, G. M., Gabibov, A. G., and Deev, S. M.
Published: 2024
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7. JEM-EUSO Collaboration contributions to the 37th International Cosmic Ray Conference

Author: Abdellaoui, G., Abe, S., Adams Jr., J. H., Allard, D., Alonso, G., Anchordoqui, L., Anzalone, A., Arnone, E., Asano, K., Attallah, R., Attoui, H., Pernas, M. Ave, Bagheri, M., Baláz, J., Bakiri, M., Barghini, D., Bartocci, S., Battisti, M., Bayer, J., Beldjilali, B., Belenguer, T., Belkhalfa, N., Bellotti, R., Belov, A. A., Benmessai, K., Bertaina, M., Bertone, P. F., Biermann, P. L., Bisconti, F., Blaksley, C., Blanc, N., Blin-Bondil, S., Bobik, P., Bogomilov, M., Bolmgren, K., Bozzo, E., Briz, S., Bruno, A., Caballero, K. S., Cafagna, F., Cambié, G., Campana, D., Capdevielle, J-N., Capel, F., Caramete, A., Caramete, L., Carlson, P., Caruso, R., Casolino, M., Cassardo, C., Castellina, A., Catalano, O., Cellino, A., Černý, K., Chikawa, M., Chiritoi, G., Christl, M. J., Colalillo, R., Conti, L., Cotto, G., Crawford, H. J., Cremonini, R., Creusot, A., Gónzalez, A. de Castro, de la Taille, C., del Peral, L., Damian, A. Diaz, Diesing, R., Dinaucourt, P., Djakonow, A., Djemil, T., Ebersoldt, A., Ebisuzaki, T., Eser, J., Fenu, F., Fernández-González, S., Ferrarese, S., Filippatos, G., Fornaro, W. I. Finch C., Fouka, M., Franceschi, A., Franchini, S., Fuglesang, C., Fujii, T., Fukushima, M., Galeotti, P., García-Ortega, E., Gardiol, D., Garipov, G. K., Gascón, E., Gazda, E., Genci, J., Golzio, A., Alvarado, C. González, Gorodetzky, P., Green, A., Guarino, F., Guépin, C., Guzmán, A., Hachisu, Y., Haungs, A., Carretero, J. Hernández, Hulett, L., Ikeda, D., Inoue, N., Inoue, S., Isgrò, F., Itow, Y., Jammer, T., Jeong, S., Joven, E., Judd, E. G., Jochum, J., Kajino, F., Kajino, T., Kalli, S., Kaneko, I., Karadzhov, Y., Kasztelan, M., Katahira, K., Kawai, K., Kawasaki, Y., Kedadra, A., Khales, H., Khrenov, B. A., Kim, Jeong-Sook, Kim, Soon-Wook, Kleifges, M., Klimov, P. A., Kolev, D., Kreykenbohm, I., Krizmanic, J. F., Królik, K., Kungel, V., Kurihara, Y., Kusenko, A., Kuznetsov, E., Lahmar, H., Lakhdari, F., Licandro, J., Campano, L. López, Martínez, F. López, Mackovjak, S., Mahdi, M., Mandát, D., Manfrin, M., Marcelli, L., Marcos, J. L., Marszał, W., Martín, Y., Martinez, O., Mase, K., Matev, R., Matthews, J. N., Mebarki, N., Medina-Tanco, G., Menshikov, A., Merino, A., Mese, M., Meseguer, J., Meyer, S. S., Mimouni, J., Miyamoto, H., Mizumoto, Y., Monaco, A., Ríos, J. A. Morales de los, Mastafa, M., Nagataki, S., Naitamor, S., Napolitano, T., Neronov, J. M. Nachtman A., Nomoto, K., Nonaka, T., Ogawa, T., Ogio, S., Ohmori, H., Olinto, A. V., Osteria, Y. Onel G., Otte, A. N., Pagliaro, A., Painter, W., Panasyuk, M. I., Panico, B., Parizot, E., Park, I. H., Pastircak, B., Paul, T., Pech, M., Pérez-Grande, I., Perfetto, F., Peter, T., Picozza, P., Pindado, S., Piotrowski, L. W., Piraino, S., Plebaniak, Z., Pollini, A., Popescu, E. M., Prevete, R., Prévôt, G., Prieto, H., Przybylak, M., Puehlhofer, G., Putis, M., Reardon, P., Reno, M. H., Reyes, M., Ricci, M., Frías, M. D. Rodríguez, Matamala, O. F. Romero, Ronga, F., Sabau, M. D., Saccá, G., Cano, G. Sáez, Sagawa, H., Sahnoune, Z., Saito, A., Sakaki, N., Salazar, H., Balanzar, J. C. Sanchez, Sánchez, J. L., Santangelo, A., Sanz-Andrés, A., Palomino, M. Sanz, Saprykin, O. A., Sarazin, F., Sato, M., Scagliola, A., Schanz, T., Schieler, H., Schovánek, P., Scotti, V., Serra, M., Sharakin, S. A., Shimizu, H. M., Shinozaki, K., Soriano, J. F., Sotgiu, A., Stan, I., Strharský, I., Sugiyama, N., Supanitsky, D., Suzuki, M., Szabelski, J., Tajima, N., Tajima, T., Takahashi, Y., Takeda, M., Takizawa, Y., Talai, M. C., Tameda, Y., Tenzer, C., Thomas, S. B., Tibolla, O., Tkachev, L. G., Tomida, T., Tone, N., Toscano, S., Traïche, M., Tsunesada, Y., Tsuno, K., Turriziani, S., Uchihori, Y., Vaduvescu, O., Valdés-Galicia, J. F., Vallania, P., Valore, L., Vankova-Kirilova, G., Venters, T. M., Vigorito, C., Villaseñor, L., Vlcek, B., von Ballmoos, P., Vrabel, M., Wada, S., Watanabe, J., Watts Jr., J., Muñoz, R. Weigand, Weindl, A., Wiencke, L., Wille, M., Wilms, J., Yamamoto, D. Winn T., Yang, J., Yano, H., Yashin, I. V., Yonetoku, D., Yoshida, S., Young, R., Zgura, I. S., Zotov, M. Yu., and Marchi, A. Zuccaro
Subjects: Astrophysics - High Energy Astrophysical Phenomena
Abstract: Compilation of papers presented by the JEM-EUSO Collaboration at the 37th International Cosmic Ray Conference (ICRC), held on July 12-23, 2021 (online) in Berlin, Germany., Comment: html page with links to the JEM-EUSO Collaboration papers presented at ICRC-2021, Berlin, Germany
Published: 2022

8. Association of constipation with increased risk of hypertension and cardiovascular events in elderly Australian patients

Author: Judkins, Courtney P., Wang, Yutang, Jelinic, Maria, Bobik, Alex, Vinh, Antony, Sobey, Christopher G., and Drummond, Grant R.
Published: 2023
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9. Quantitative proteomic landscape of unstable atherosclerosis identifies molecular signatures and therapeutic targets for plaque stabilization

Author: Chen, Yung-Chih, Smith, Meaghan, Ying, Ya-Lan, Makridakis, Manousos, Noonan, Jonathan, Kanellakis, Peter, Rai, Alin, Salim, Agus, Murphy, Andrew, Bobik, Alex, Vlahou, Antonia, Greening, David W., and Peter, Karlheinz
Published: 2023
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10. Depletion of follicular B cell-derived antibody secreting cells does not attenuate angiotensin II-induced hypertension or vascular compliance

Author: Hericka Bruna Figueiredo Galvao, Maggie Lieu, Seyuri Moodley, Henry Diep, Maria Jelinic, Alexander Bobik, Christopher G. Sobey, Grant R. Drummond, and Antony Vinh
Subjects: hypertension, B cells, plasma cells, antibodies, angiotensin II, Blimp-1, Diseases of the circulatory (Cardiovascular) system, RC666-701
Abstract: IntroductionMarginal zone and follicular B cells are known to contribute to the development of angiotensin II-induced hypertension in mice, but the effector function(s) mediating this effect (e.g., antigen presentation, antibody secretion and/or cytokine production) are unknown. B cell differentiation into antibody secreting cells (ASCs) requires the transcription factor Blimp-1. Here, we studied mice with a Blimp-1 deficiency in follicular B cells to evaluate whether antibody secretion underlies the pro-hypertensive action of B cells.Methods10- to 14-week-old male follicular B cell Blimp-1 knockout (FoB-Blimp-1-KO) and floxed control mice were subcutaneously infused with angiotensin II (0.7 mg/kg/d) or vehicle (0.1% acetic acid in saline) for 28 days. BP was measured by tail-cuff plethysmography or radiotelemetry. Pulse wave velocity was measured by ultrasound. Aortic collagen was quantified by Masson's trichrome staining. Cell types and serum antibodies were quantified by flow cytometry and a bead-based multiplex assay, respectively.ResultsIn control mice, angiotensin II modestly increased serum IgG3 levels and markedly increased BP, cardiac hypertrophy, aortic stiffening and fibrosis. FoB-Blimp-1-KO mice exhibited impaired IgG1, IgG2a and IgG3 production despite having comparable numbers of B cells and ASCs to control mice. Nevertheless, FoB-Blimp-1-KO mice still developed hypertension, cardiac hypertrophy, aortic stiffening and fibrosis following angiotensin II infusion.ConclusionsInhibition of follicular B cell differentiation into ASCs did not protect against angiotensin II-induced hypertension or vascular compliance. Follicular B cell functions independent of their differentiation into ASCs and ability to produce high-affinity antibodies, or other B cell subtypes, are likely to be involved in angiotensin II-induced hypertension.
Published: 2024
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11. Developments and results in the context of the JEM-EUSO program obtained with the ESAF simulation and analysis framework

Author: S. Abe, J. H. Adams, D. Allard, P. Alldredge, L. Anchordoqui, A. Anzalone, E. Arnone, B. Baret, D. Barghini, M. Battisti, J. Bayer, R. Bellotti, A. A. Belov, M. Bertaina, P. F. Bertone, M. Bianciotto, P. L. Biermann, F. Bisconti, C. Blaksley, S. Blin-Bondil, P. Bobik, K. Bolmgren, S. Briz, J. Burton, F. Cafagna, G. Cambié, D. Campana, F. Capel, R. Caruso, M. Casolino, C. Cassardo, A. Castellina, K. Černý, M. J. Christl, R. Colalillo, L. Conti, G. Cotto, H. J. Crawford, R. Cremonini, A. Creusot, A. Cummings, A. de Castro Gónzalez, C. de la Taille, L. del Peral, R. Diesing, P. Dinaucourt, A. Di Nola, A. Ebersoldt, T. Ebisuzaki, J. Eser, F. Fenu, S. Ferrarese, G. Filippatos, W. W. Finch, F. Flaminio, C. Fornaro, D. Fuehne, C. Fuglesang, M. Fukushima, D. Gardiol, G. K. Garipov, A. Golzio, P. Gorodetzky, F. Guarino, C. Guépin, A. Guzmán, A. Haungs, T. Heibges, J. Hernández-Carretero, F. Isgrò, E. G. Judd, F. Kajino, I. Kaneko, Y. Kawasaki, M. Kleifges, P. A. Klimov, I. Kreykenbohm, J. F. Krizmanic, V. Kungel, E. Kuznetsov, F. López Martínez, S. Mackovjak, D. Mandát, M. Manfrin, A. Marcelli, L. Marcelli, W. Marszał, J. N. Matthews, A. Menshikov, T. Mernik, M. Mese, S. S. Meyer, J. Mimouni, H. Miyamoto, Y. Mizumoto, A. Monaco, J.A Morales de los Ríos, S. Nagataki, J. M. Nachtman, D. Naumov, A. Neronov, T. Nonaka, T. Ogawa, S. Ogio, H. Ohmori, A. V. Olinto, Y. Onel, G. Osteria, A. Pagliaro, B. Panico, E. Parizot, I. H. Park, B. Pastircak, T. Paul, M. Pech, F. Perfetto, P. Picozza, L. W. Piotrowski, Z. Plebaniak, J. Posligua, R. Prevete, G. Prévôt, H. Prieto, M. Przybylak, M. Putis, E. Reali, P. Reardon, M. H. Reno, M. Ricci, M. Rodríguez Frías, G. Romoli, G. Sáez Cano, H. Sagawa, N. Sakaki, A. Santangelo, O. A. Saprykin, F. Sarazin, M. Sato, H. Schieler, P. Schovánek, V. Scotti, S. Selmane, S. A. Sharakin, K. Shinozaki, J. F. Soriano, J. Szabelski, N. Tajima, T. Tajima, Y. Takahashi, M. Takeda, Y. Takizawa, C. Tenzer, S. B. Thomas, L. G. Tkachev, T. Tomida, S. Toscano, M. Traïche, D. Trofimov, K. Tsuno, P. Vallania, L. Valore, T. M. Venters, C. Vigorito, P. von Ballmoos, M. Vrabel, S. Wada, J. Watts, A. Weindl, L. Wiencke, J. Wilms, D. Winn, H. Wistrand, I. V. Yashin, R. Young, and M. Yu. Zotov
Subjects: Astrophysics, QB460-466, Nuclear and particle physics. Atomic energy. Radioactivity, QC770-798
Abstract: Abstract JEM-EUSO is an international program for the development of space-based Ultra-High Energy Cosmic Ray observatories. The program consists of a series of missions which are either under development or in the data analysis phase. All instruments are based on a wide-field-of-view telescope, which operates in the near-UV range, designed to detect the fluorescence light emitted by extensive air showers in the atmosphere. We describe the simulation software ESAF in the framework of the JEM-EUSO program and explain the physical assumptions used. We present here the implementation of the JEM-EUSO, POEMMA, K-EUSO, TUS, Mini-EUSO, EUSO-SPB1 and EUSO-TA configurations in ESAF. For the first time ESAF simulation outputs are compared with experimental data.
Published: 2023
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12. Time and self-management in professional time in teachers' opinions

Author: Bogumiła Maria Bobik
Subjects: teacher, diagnostic tests, time, time management, professional tasks, Social Sciences
Abstract: Objectives Presentation of teachers' opinions on the perception of time and managing their professional tasks during working time. Material and methods The research was of a diagnostic nature, conducted through usage of a diagnostic survey, particularly the Time Methapor questionnaire by Małgorzata Sobol-Kwapińska. Additionally, the respondents answered questions contained in the inventory of teacher’s tasks, developed by the author. Results The assessment of individual time categories by the majority of respondents is in the upper limit of low results, with the exception of the Fast passing of time scale and the Pleasant time subscale, which obtained an average result. The respondents considered most of the given tasks to be urgent and important (44%), followed by tasks that were not urgent and important (25%), urgent and not important (19%), and not urgent and not important (12%). Conclusions Research has shown that teachers experience time calmly and confidently to a small extent, and derive joy and pleasure from it to an average degree. They have a low sense of efficient and creative use of time. They do not see time as an enemy, so they rarely point to its negative aspects. They have a feeling of time passing quickly. Some results suggest that they may have problems achieving goals, planning and organizing their own time. The distribution of tasks included in the Time Management matrix shows that almost half of them were considered urgent and important. This may be due to the fact that these tasks fall into key areas of their work. The obtained results require further research, which may enrich the area of pedeutology with the issue of time as a category and bring closer various solutions in planning professional work and personal development of teachers.
Published: 2023
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13. EFFECT OF MEAT AND BONE MEAL AND EFFECTIVE MICROORGANISMS ON CONTENT AND COMPOSITION OF PROTEIN IN CROPS PART II. FABA BEAN AND WINTER WHEAT.

Author: Wojtkowiak, Katarzyna and Stępień, Arkadiusz
Subjects: ORGANIC fertilizers, WINTER wheat, FAVA bean, CYTOSKELETAL proteins, GRAIN, MEAT, BONES
Abstract: Copyright of Acta Scientiarum Polonorum. Agricultura is the property of University of Technology & Life Sciences and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Published: 2011

14. Association of constipation with increased risk of hypertension and cardiovascular events in elderly Australian patients

Author: Courtney P. Judkins, Yutang Wang, Maria Jelinic, Alex Bobik, Antony Vinh, Christopher G. Sobey, and Grant R. Drummond
Subjects: Medicine, Science
Abstract: Abstract The association between constipation and cardiovascular risk is unclear. This population-level matched cohort study compared the association of constipation with hypertension and incident cardiovascular events in 541,172 hospitalized patients aged ≥ 60 years. For each constipation admission, one exact age-matched non-constipated admission was randomly selected from all hospitalizations within 2 weeks to form the comparison cohort. The association of constipation with hypertension and cardiovascular events (myocardial infarction, angina, stroke and transient ischemic attack) were analysed using a series of binary logistic regressions adjusting for age, sex, cardiovascular risk factors, gastrointestinal disorders and sociological factors. Patients with constipation had a higher multivariate-adjusted risk for hypertension (odds ratio [OR], 1.96; 95% confidence interval [CI] 1.94–1.99; P
Published: 2023
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15. Contributions to the 36th International Cosmic Ray Conference (ICRC 2019) of the JEM-EUSO Collaboration

Author: Abdellaoui, G., Abe, S., Adams Jr., J. H., Ahriche, A., Allard, D., Allen, L., Alonso, G., Anchordoqui, L., Anzalone, A., Arai, Y., Asano, K., Attallah, R., Attoui, H., Pernas, M. Ave, Bacholle, S., Bakiri, M., Baragatti, P., Barrillon, P., Bartocci, S., Bayer, J., Beldjilali, B., Belenguer, T., Belkhalfa, N., Bellotti, R., Belov, A., Belov, K., Benmessai, K., Bertaina, M., Biermann, P. L., Biktemerova, S., Bisconti, F., Blaksley, C., Blanc, N., Błęcki, J., Blin-Bondil, S., Bobik, P., Bogomilov, M., Bozzo, E., Pacheco, S. Briz, Bruno, A., Caballero, K. S., Cafagna, F., Campana, D., Capdevielle, J-N., Capel, F., Caramete, A., Caramete, L., Carlson, P., Caruso, R., Casolino, M., Cassardo, C., Castellina, A., Catalano, O., Cellino, A., Chikawa, M., Chiritoi, G., Christl, M. J., Connaughton, V., Conti, L., Cotto, G., Crawford, H. J., Cremonini, R., Creusot, A., Csorna, S., Cummings, A., Dagoret-Campagne, S., Gónzalez, A. de Castro, De Donato, C., de la Taille, C., De Santis, C., del Peral, L., Di Martino, M., Damian, A. Diaz, Djemil, T., Dutan, I., Ebersoldt, A., Ebisuzaki, T., Engel, R., Eser, J., Fenu, F., Fernández-González, S., Ferrarese, S., Flamini, M., Fornaro, C., Fouka, M., Franceschi, A., Franchini, S., Fuglesang, C., Fujii, T., Fujimoto, J., Fukushima, M., Galeotti, P., García-Ortega, E., Garipov, G., Gascón, E., Genci, J., Giraudo, G., Alvarado, C. González, Gorodetzky, P., Greg, R., Guarino, F., Guzmán, A., Hachisu, Y., Haiduc, M., Harlov, B., Haungs, A., Carretero, J. Hernández, Cruz, W. Hidber, Ikeda, D., Inoue, N., Inoue, S., Isgrò, F., Itow, Y., Jammer, T., Jeong, S., Joven, E., Judd, E. G., Jung, A., Jochum, J., Kajino, F., Kajino, T., Kalli, S., Kaneko, I., Karadzhov, Y., Karczmarczyk, J., Katahira, K., Kawai, K., Kawasaki, Y., Kedadra, A., Khales, H., Khrenov, B. A., Kim, Jeong-Sook, Kim, Soon-Wook, Kleifges, M., Klimov, P. A., Kolev, D., Krantz, H., Kreykenbohm, I., Krizmanic, J. F., Kudela, K., Kurihara, Y., Kusenko, A., Kuznetsov, E., La Barbera, A., Lahmar, H., Lakhdari, F., Larsson, O., Lee, J., Licandro, J., Campano, L. López, Martínez, F. López, Maccarone, M. C., Mackovjak, S., Mahdi, M., Maravilla, D., Marcelli, L., Marcos, J. L., Marini, A., Marszał, W., Martens, K., Martín, Y., Martinez, O., Martucci, M., Masciantonio, G., Mase, K., Matev, R., Matthews, J. N., Mebarki, N., Medina-Tanco, G., Menshikov, A., Merino, A., Meseguer, J., Meyer, S. S., Mimouni, J., Miyamoto, H., Mizumoto, Y., Monaco, A., Ríos, J. A. Morales de los, Mustafa, M., Nagataki, S., Naitamor, S., Napolitano, T., Nava, R., Neronov, A., Nomoto, K., Nonaka, T., Ogawa, T., Ogio, S., Ohmori, H., Olinto, A. V., Orleaánski, P., Osteria, G., Pagliaro, A., Painter, W., Panasyuk, M. I., Panico, B., Parizot, E., Park, I. H., Pastircak, B., Patzak, T., Paul, T., Pérez-Grande, I., Perfetto, F., Peter, T., Picozza, P., Pindado, S., Piotrowski, L. W., Piraino, S., Placidi, L., Plebaniak, Z., Pliego, S., Pollini, A., Polonski, Z., Popescu, E. M., Prat, P., Prévôt, G., Prieto, H., Puehlhofer, G., Putis, M., Rabanal, J., Radu, A. A., Reyes, M., Rezazadeh, M., Ricci, M., Frías, M. D. Rodríguez, Ronga, F., Roudil, G., Rusinov, I., Rybczyński, M., Sabau, M. D., Cano, G. Sáaez, Sagawa, H., Sahnoune, Z., Saito, A., Sakaki, N., Salazar, H., Balanzar, J. C. Sanchez, Sánchez, J. L., Santangelo, A., Sanz-Andrés, A., Palomino, M. Sanz, Saprykin, O., Sarazin, F., Sato, M., Schanz, T., Schieler, H., Scotti, V., Selmane, S., Semikoz, D., Serra, M., Sharakin, S., Shimizu, H. M., Shinozaki, K., Shirahama, T., Spataro, B., Stan, I., Sugiyama, T., Supanitsky, D., Suzuki, M., Szabelska, B., Szabelski, J., Tajima, N., Tajima, T., Takahashi, Y., Takami, H., Takeda, M., Takizawa, Y., Talai, M. C., Tenzer, C., Thomas, S. B., Tibolla, O., Tkachev, L., Tokuno, H., Tomida, T., Tone, N., Toscano, S., Traïche, M., Tsenov, R., Tsunesada, Y., Tsuno, K., Tubbs, J., Turriziani, S., Uchihori, Y., Vaduvescu, O., Valdés-Galicia, J. F., Vallania, P., Vankova, G., Vigorito, C., Villaseñor, L., Vlcek, B., von Ballmoos, P., Vrabel, M., Wada, S., Watanabe, J., Watts Jr., J., Weber, M., Muñoz, R. Weigand, Weindl, A., Wiencke, L., Wille, M., Wilms, J., Włodarczyk, Z., Yamamoto, T., Yang, J., Yano, H., Yashin, I. V., Yonetoku, D., Yoshida, S., Young, R., Zgura, I. S, Zotov, M. Yu., and Marchi, A. Zuccaro
Subjects: Astrophysics - High Energy Astrophysical Phenomena
Abstract: Compilation of papers presented by the JEM-EUSO Collaboration at the 36th International Cosmic Ray Conference (ICRC), held July 24 through August 1, 2019 in Madison, Wisconsin., Comment: links to the 24 papers published in arXiv
Published: 2019

16. INTEGRATION AND ECONOMIC DEVELOPMENT IN LATIN AMERICA: AN INTERPRETATION OF CELSO FURTADO’S CONTRIBUTIONS

Author: Márcio Bobik Braga and Alexandre Ganan de Brites Figueiredo
Subjects: regional economic integration of latin america, economic development, economic thought of celso furtado, Social Sciences, International relations, JZ2-6530, Political science (General), JA1-92
Abstract: This article aims to analyze the role of regional economic integration for the economic development of Latin America, taking as a reference the contributions of Celso Furtado. Based on theoretical and empirical (historical) arguments, it is intended to demonstrate that Celso Furtado ́s regarding the integration of Latin American countries involve a complex adequacy of national, economic and political projects, around a regional project.
Published: 2023
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17. Quantitative proteomic landscape of unstable atherosclerosis identifies molecular signatures and therapeutic targets for plaque stabilization

Author: Yung-Chih Chen, Meaghan Smith, Ya-Lan Ying, Manousos Makridakis, Jonathan Noonan, Peter Kanellakis, Alin Rai, Agus Salim, Andrew Murphy, Alex Bobik, Antonia Vlahou, David W. Greening, and Karlheinz Peter
Subjects: Biology (General), QH301-705.5
Abstract: Protein signatures of unstable and stable atherosclerosis are defined by quantitative proteomics using a preclinical mouse model of plaque instability/rupture.
Published: 2023
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18. Reduced Insulin Resistance and Oxidative Stress in a Mouse Model of Metabolic Syndrome following Twelve Weeks of Citrus Bioflavonoid Hesperidin Supplementation: A Dose–Response Study

Author: Abdulsatar Jamal, Holly Brettle, Dina A. Jamil, Vivian Tran, Henry Diep, Alexander Bobik, Chris van der Poel, Antony Vinh, Grant R. Drummond, Colleen J. Thomas, Maria Jelinic, and Hayder A. Al-Aubaidy
Subjects: hesperidin, metabolic syndrome, HbA1c, insulin, 8-hydroxydeoxyguanosine, Microbiology, QR1-502
Abstract: Metabolic syndrome (MetS) is a cluster of metabolic abnormalities affecting ~25% of adults and is linked to chronic diseases such as cardiovascular disease, cancer, and neurodegenerative diseases. Oxidative stress and inflammation are key drivers of MetS. Hesperidin, a citrus bioflavonoid, has demonstrated antioxidant and anti-inflammatory properties; however, its effects on MetS are not fully established. We aimed to determine the optimal dose of hesperidin required to improve oxidative stress, systemic inflammation, and glycemic control in a novel mouse model of MetS. Male 5-week-old C57BL/6 mice were fed a high-fat, high-salt, high-sugar diet (HFSS; 42% kcal fat content in food and drinking water with 0.9% saline and 10% high fructose corn syrup) for 16 weeks. After 6 weeks of HFSS, mice were randomly allocated to either the placebo group or low- (70 mg/kg/day), mid- (140 mg/kg/day), or high-dose (280 mg/kg/day) hesperidin supplementation for 12 weeks. The HFSS diet induced significant metabolic disturbances. HFSS + placebo mice gained almost twice the weight of control mice (p < 0.0001). Fasting blood glucose (FBG) increased by 40% (p < 0.0001), plasma insulin by 100% (p < 0.05), and HOMA-IR by 150% (p < 0.0004), indicating insulin resistance. Hesperidin supplementation reduced plasma insulin by 40% at 140 mg/kg/day (p < 0.0001) and 50% at 280 mg/kg/day (p < 0.005). HOMA-IR decreased by 45% at both doses (p < 0.0001). Plasma hesperidin levels significantly increased in all hesperidin groups (p < 0.0001). Oxidative stress, measured by 8-OHdG, was increased by 40% in HFSS diet mice (p < 0.001) and reduced by 20% with all hesperidin doses (p < 0.005). In conclusion, hesperidin supplementation reduced insulin resistance and oxidative stress in HFSS-fed mice, demonstrating its dose-dependent therapeutic potential in MetS.
Published: 2024
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19. Machine Learning Approach for Air Shower Recognition in EUSO-SPB Data

Author: Vrábel, Michal, Genči, Ján, Bobik, Pavol, and Bisconti, Francesca
Subjects: Astrophysics - Instrumentation and Methods for Astrophysics, Computer Science - Machine Learning
Abstract: The main goal of The Extreme Universe Space Observatory on a Super Pressure Balloon (EUSO-SPB1) was to observe from above extensive air showers caused by ultra-high energy cosmic rays. EUSO-SPB1 uses a fluorescence detector that observes the atmosphere in a nadir observation mode from a near space altitude. During the 12-day flight, an onboard first level trigger detected more than \num{175000} candidate events. This paper presents an approach to recognize air showers in this dataset. The approach uses a feature extraction method to create a simpler representation of an event and then it uses established machine learning techniques to classify data into at least two classes - shower and noise. The machine learning models are trained on a set of air shower simulations put on top of the background observed during the flight and a set of events from the flight. We present the efficiency of the method on datasets of simulated events. The flight data events are also used in unsupervised learning methods to identify groups of events with similar features. The presented methods allow us to shorten the candidate events list and, thanks to the groups of similar events identified by the unsupervised methods, the classification of the triggered events is made simpler., Comment: 8 pages, 8 figures, ICRC2019
Published: 2019

20. A systematic archaeological survey in the environs of Khaytabad Tepa (Southern Uzbekistan). Preliminary report on the 2021 pilot season

Author: Jakub Havlík, Ján Bobik, Vendula Dědková, Kateřina Dontová, Jan Krčál, Jana Matznerová, Elena Paralovo, Razieh Taasob, Kahramon Toshaliyev, Jan Ždimera, and Shapulat Shaydullaev
Subjects: surface survey, ploughsoil assemblages, central asian archaeology, northern bactria, yaz culture, Archaeology, CC1-960
Abstract: Tepa sites have oÁen been the focus of archaeological investigations in the lowland areas of Soviet and post- -Soviet Central Asia. is bias frequently led to paying only a lile aention to the surrounding landscape and its potential for the study of historical selement and land use. Moreover, in these environs archaeologists face particularly unfavourable conditions in the landscape, which has been radically transformed by decades of mechanised agriculture and selement growth. e newly launched project of the Czech-Uzbekistani Archaeological Mission aims to answer the challenges of research in the heavily exploited lowlands of southern Uzbekistan and explore the surroundings, supposedly an economic territory, of Khaytabad Tepa, a walled selement occupied between the Achaemenid period and the Middle Ages. For the investigation of various parts of a culturally and physically diverse landscape (village areas, fields, tepa mounds), a flexible methodology was developed, building on an intensive surface survey as the dominant research component to analyse the Khaytabad Tepa surroundings. Given the initial stage of the research, this report focuses on the background, objectives, and methodology of the project and evaluates the 2021 pilot season. e amount and chronological range of collected material point to the great potential of the adopted approach as well as the research area itself. e identified artefact scaers indicate a substantially more complex selement development than has been acknowledged so far: e collected poery assemblages largely correspond to the occupation timespan of the central walled selement. e widespread distribution of Iron Age and Middle Ages material suggests an extensive exploitation of the area in these particular periods.
Published: 2022

21. The Environmental Context of Educational Work with the Youth at Risk of Social Maladjustment

Author: Bogumiła Maria Bobik
Subjects: prevention, youth, learning environment, social risks, diagnostic study, Social Sciences
Abstract: Objectives The article aims to moot various problems experienced by adolescents brought up in families and local environment prone to social pathologies. What serves as the grounds for discussion herein is the example of Bytom (a Polish city located in Upper Silesia) which, after 1989, was particularly affected by the transformations connected with the political, social and economic changes following the fall of communism. Material and methods In the course of research, the diagnostic study method was applied together with the following instruments: a questionnaire, document analysis, and observation. The survey was conducted among adolescents over the age of 13 and among their teachers in a selected school located in Bytom Results It was established that both the family and local environment affect the process of social adaptation when it comes to adolescents. The following factors can pose a threat to young people’s development: a low standard of living, bad example set by adults, poverty, unemployment, addictions, loosened family bonds, and peer pressure. Conclusions Growing up in dysfunctional environment may lead to a dearth of interests and life aspirations, limited models of spending leisure time, and a lack of authorities. The youth need support of educational and social welfare institutions.
Published: 2022
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22. Proteasome inhibition reduces plasma cell and antibody secretion, but not angiotensin II-induced hypertension

Author: Hericka Bruna Figueiredo Galvao, Quynh Nhu Dinh, Jordyn M. Thomas, Flavia Wassef, Henry Diep, Alex Bobik, Christopher G. Sobey, Grant R. Drummond, and Antony Vinh
Subjects: hypertension, bortezomib, antibody secreting cells, immunoglobulins, angiotensin II, proteasome inhibition, Diseases of the circulatory (Cardiovascular) system, RC666-701
Abstract: IntroductionDepletion of mature B cells affords protection against experimental hypertension. However, whether B cell-mediated hypertension is dependent on differentiation into antibody-secreting cells (ASCs) remains unclear. Using the proteasome inhibitor, bortezomib, the present study tested the effect of ASC reduction on angiotensin II-induced hypertension.MethodsMale C57BL6/J mice were infused with angiotensin II (0.7 mg/kg/day; s.c.) for 28 days via osmotic minipump to induce hypertension. Normotensive control mice received saline infusion. Bortezomib (750 μg/kg) or vehicle (0.1% DMSO) was administered (i.v.) 3 days prior to minipump implantation, and twice weekly thereafter. Systolic blood pressure was measured weekly using tail-cuff plethysmography. Spleen and bone marrow B1 (CD19+B220−), B2 (B220+CD19+) and ASCs (CD138hiSca-1+Blimp-1+) were enumerated by flow cytometry. Serum immunoglobulins were quantified using a bead-based immunoassay.ResultsBortezomib treatment reduced splenic ASCs by ∼68% and ∼64% compared to vehicle treatment in normotensive (2.00 ± 0.30 vs. 0.64 ± 0.15 × 105 cells; n = 10–11) and hypertensive mice (0.52 ± 0.11 vs. 0.14 ± 0.02 × 105 cells; n = 9–11), respectively. Bone marrow ASCs were also reduced by bortezomib in both normotensive (4.75 ± 1.53 vs. 1.71 ± 0.41 × 103 cells; n = 9–11) and hypertensive mice (4.12 ± 0.82 vs. 0.89 ± 0.18 × 103 cells; n = 9–11). Consistent with ASC reductions, bortezomib reduced serum IgM and IgG2a in all mice. Despite these reductions in ASCs and antibody levels, bortezomib did not affect angiotensin II-induced hypertension over 28 days (vehicle: 182 ± 4 mmHg vs. bortezomib: 177 ± 7 mmHg; n = 9–11).ConclusionReductions in ASCs and circulating IgG2a and IgM did not ameliorate experimental hypertension, suggesting other immunoglobulin isotypes or B cell effector functions may promote angiotensin II-induced hypertension.
Published: 2023
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23. First observations of speed of light tracks by a fluorescence detector looking down on the atmosphere

Author: Abdellaoui, G., Abe, S., Adams Jr., J. H., Ahriche, A., Allard, D., Allen, L., Alonso, G., Anchordoqui, L., Anzalone, A., Arai, Y., Asano, K., Attallah, R., Attoui, H., Pernas, M. Ave, Bacholle, S., Bakiri, M., Baragatti, P., Barrillon, P., Bartocci, S., Bayer, J., Beldjilali, B., Belenguer, T., Belkhalfa, N., Bellotti, R., Belov, A., Belov, K., Benmessai, K., Bertaina, M., Biermann, P. L., Biktemerova, S., Bisconti, F., Blanc, N., Błȩcki, J., Blin-Bondil, S., Bobik, P., Bogomilov, M., Bozzo, E., Bruno, A., Caballero, K. S., Cafagna, F., Campana, D., Capdevielle, J-N., Capel, F., Caramete, A., Caramete, L., Carlson, P., Caruso, R., Casolino, M., Cassardo, C., Castellina, A., Catalano, C. Catalano O., Cellino, A., Chikawa, M., Chiritoi, G., Christl, M. J., Connaughton, V., Conti, L., Cordero, G., Cotto, G., Crawford, H. J., Cremonini, R., Csorna, S., Cummings, A., Dagoret-Campagne, S., De Donato, C., de la Taille, C., De Santis, C., del Peral, L., Di Martino, M., Damian, A. Diaz, Djemil, T., Dutan, I., Ebersoldt, A., Ebisuzaki, T., Engel, R., Eser, J., Fenu, F., Fernández-González, S., Fernández-Soriano, J., Ferrarese, S., Flamini, M., Fornaro, C., Fouka, M., Franceschi, A., Franchini, S., Fuglesang, C., Fujii, T., Fujimoto, J., Fukushima, M., Galeotti, P., García-Ortega, E., Garipov, G., Gascón, E., Genci, J., Giraudo, G., Alvarado, C. González, Gorodetzky, P., Greg, R., Guarino, F., Guzmán, A., Hachisu, Y., Haiduc, M., Harlov, B., Haungs, A., Carretero, J. Hernández, Cruz, W. Hidber, Ikeda, D., Inoue, N., Inoue, S., Isgrò, F., Itow, Y., Jammer, T., Jeong, S., Joven, E., Judd, E. G., Jung, A., Jochum, J., Kajino, F., Kajino, T., Kalli, S., Kaneko, I., Karadzhov, Y., Karczmarczyk, J., Katahira, K., Kawai, K., Kawasaki, Y., Kedadra, A., Khales, H., Khrenov, B. A., Kim, Jeong-Sook, Kim, Soon-Wook, Kleifges, M., Klimov, P. A., Kolev, D., Krantz, H., Kreykenbohm, I., Kudela, K., Kurihara, Y., Kusenko, A., Kuznetsov, E., La Barbera, A., Lachaud, C., Lahmar, H., Lakhdari, F., Larson, R., Larsson, O., Lee, J., Licandro, J., Campano, L. López, Maccarone, M. C., Mackovjak, S., Mahdi, M., Maravilla, D., Marcelli, L., Marcos, J. L., Marini, A., Marszał, W., Martens, K., Martín, Y., Martinez, O., Martucci, M., Masciantonio, G., Mase, K., Mastafa, M., Matev, R., Matthews, J. N., Mebarki, N., Medina-Tanco, G., Mendoza, M. A., Menshikov, A., Merino, A., Meseguer, J., Meyer, S. S., Mimouni, J., Miyamoto, H., Mizumoto, Y., Monaco, A., Ríos, J. A. Morales de los, Nagataki, C. Moretto S., Naitamor, S., Napolitano, T., Naslund, W., Nava, R., Neronov, A., Nomoto, K., Nonaka, T., Ogawa, T., Ogio, S., Ohmori, H., Olinto, A. V., Orleański, P., Osteria, G., Pagliaro, A., Painter, W., Panasyuk, M. I., Panico, B., Pasqualino, G., Parizot, E., Park, I. H., Pastircak, B., Patzak, T., Paul, T., Pérez-Grande, I., Perfetto, F., Peter, T., Picozza, P., Pindado, S., Piotrowski, L. W., Piraino, S., Placidi, L., Plebaniak, Z., Pliego, S., Pollini, A., Polonski, Z., Popescu, E. M., Prat, P., Prévôt, G., Prieto, H., Puehlhofer, G., Putis, M., Rabanal, J., Radu, A. A., Reyes, M., Rezazadeh, M., Ricci, M., Frías, M. D. Rodríguez, Rodencal, M., Ronga, F., Roudil, G., Rusinov, I., Rybczyński, M., Sabau, M. D., Cano, G. Sáez, Sagawa, H., Sahnoune, Z., Saito, A., Sakaki, N., Salazar, H., Balanzar, J. C. Sanchez, Sánchez, J. L., Santangelo, A., Sanz-Andrés, A., Palomino, M. Sanz, Saprykin, O., Sarazin, F., Sato, M., Schanz, T., Schieler, H., Scotti, V., Selmane, S., Semikoz, D., Serra, M., Sharakin, S., Shimizu, H. M., Shinozaki, K., Shirahama, T., Spataro, B., Stan, I., Sugiyama, T., Supanitsky, D., Suzuki, M., Szabelska, B., Szabelski, J., Tajima, N., Tajima, T., Takahashi, Y., Takami, H., Takeda, M., Takizawa, Y., Talai, M. C., Tenzer, C., Thomas, S. B., Tibolla, O., Tkachev, L., Tokuno, H., Tomida, T., Tone, N., Toscano, S., Traïche, M., Tsenov, R., Tsunesada, Y., Tsuno, K., Tubbs, J., Turriziani, S., Uchihori, Y., Vaduvescu, O., Valdés-Galicia, J. F., Vallania, P., Vankova, G., Vigorito, C., Villaseñor, L., Vlcek, B., von Ballmoos, P., Vrabel, M., Wada, S., Watanabe, J., Watts Jr., J., Weber, M., Muñoz, R. Weigand, Weindl, A., Wiencke, L., Wille, M., Wilms, J., Włodarczyk, Z., Yamamoto, T., Yang, J., Yano, H., Yashin, I. V., Yonetoku, D., Yoshida, S., Young, R., Zgura, I. S, Zotov, M. Yu., and Marchi, A. Zuccaro
Subjects: Astrophysics - Instrumentation and Methods for Astrophysics
Abstract: EUSO-Balloon is a pathfinder mission for the Extreme Universe Space Observatory onboard the Japanese Experiment Module (JEM-EUSO). It was launched on the moonless night of the 25$^{th}$ of August 2014 from Timmins, Canada. The flight ended successfully after maintaining the target altitude of 38 km for five hours. One part of the mission was a 2.5 hour underflight using a helicopter equipped with three UV light sources (LED, xenon flasher and laser) to perform an inflight calibration and examine the detectors capability to measure tracks moving at the speed of light. We describe the helicopter laser system and details of the underflight as well as how the laser tracks were recorded and found in the data. These are the first recorded laser tracks measured from a fluorescence detector looking down on the atmosphere. Finally, we present a first reconstruction of the direction of the laser tracks relative to the detector., Comment: 18 pages, 14 figures
Published: 2018
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24. Efficient allelic-drive in Drosophila.

Author: Guichard, Annabel, Haque, Tisha, Bobik, Marketta, Xu, Xiang-Ru S, Klanseck, Carissa, Kushwah, Raja Babu Singh, Berni, Mateus, Kaduskar, Bhagyashree, Gantz, Valentino M, and Bier, Ethan
Subjects: Animals, Animals, Genetically Modified, Drosophila, RNA, Guide, DNA Mutational Analysis, Inheritance Patterns, Mosaicism, Alleles, Agriculture, Female, Male, DNA End-Joining Repair, CRISPR-Cas Systems, Gene Editing, Gene Drive Technology, Genetically Modified, RNA, Guide
Abstract: Gene-drive systems developed in several organisms result in super-Mendelian inheritance of transgenic insertions. Here, we generalize this "active genetic" approach to preferentially transmit allelic variants (allelic-drive) resulting from only a single or a few nucleotide alterations. We test two configurations for allelic-drive: one, copy-cutting, in which a non-preferred allele is selectively targeted for Cas9/guide RNA (gRNA) cleavage, and a more general approach, copy-grafting, that permits selective inheritance of a desired allele located in close proximity to the gRNA cut site. We also characterize a phenomenon we refer to as lethal-mosaicism that dominantly eliminates NHEJ-induced mutations and favors inheritance of functional cleavage-resistant alleles. These two efficient allelic-drive methods, enhanced by lethal mosaicism and a trans-generational drive process we refer to as "shadow-drive", have broad practical applications in improving health and agriculture and greatly extend the active genetics toolbox.
Published: 2019

25. An analytically iterative method for solving problems of cosmic-ray modulation

Author: Kolesnyk, Yuriy L., Bobik, Pavol, Shakhov, Boris A., and Putis, Marian
Subjects: Astrophysics - Instrumentation and Methods for Astrophysics, Astrophysics - High Energy Astrophysical Phenomena, Mathematical Physics
Abstract: The development of an analytically iterative method for solving steady-state as well as unsteady-state problems of cosmic-ray (CR) modulation is proposed. Iterations for obtaining the solutions are constructed for the spherically symmetric form of the CR propagation equation. The main solution of the considered problem consists of the zero-order solution that is obtained during the initial iteration and amendments that may be obtained by subsequent iterations. The finding of the zero-order solution is based on the CR isotropy during propagation in the space, whereas the anisotropy is taken into account when finding the next amendments. To begin with, the method is applied to solve the problem of CR modulation where the diffusion coefficient $\kappa$ and the solar wind speed $u$ are constants with an Local Interstellar Spectra (LIS) spectrum. The solution obtained with two iterations was compared with an analytical solution and with numerical solutions. Finally, solutions that have only one iteration for two problems of CR modulation with $u = constant$ and the same form of LIS spectrum were obtained and tested against numerical solutions. For the first problem, $\kappa$ is proportional to the momentum of the particle $p$, so it has the form $\kappa=k_0\eta$, where $\eta=\frac{p}{m_0c}$. For the second problem, the diffusion coefficient is given in the form $\kappa=k_0\beta\eta$, where $\beta=\frac{v}{c}$ is the particle speed relative to the speed of light. There was a good matching of the obtained solutions with the numerical solutions as well as with the analytical solution for the problem where $\kappa = constant$., Comment: 13 pages, 9 figures and 2 tables
Published: 2017
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26. Assessment of different markers of ovarian reserve in women with papillary thyroid cancer treated with radioactive iodine

Author: Agnieszka Adamska, Paulina Tomczuk-Bobik, Anna Beata Popławska-Kita, Katarzyna Siewko, Angelika Buczyńska, Piotr Szumowski, Łukasz Żukowski, Janusz Myśliwiec, Monika Zbucka-Krętowska, Marcin Adamski, and Adam Jacek Krętowski
Subjects: ovarian reserve, ptc, rai, amh, Diseases of the endocrine glands. Clinical endocrinology, RC648-665
Abstract: Treatment with radioactive iodine (RAI) in women with differenti ated thyroid cancer is associated with decreased serum concentrations of anti-Mülle rian hormone (AMH); however, other markers have not been investigated. Therefore, t his study aimed to evaluate the effect of RAI treatment on antral follicle count (AFC) and the serum concentration of inhibin B, follicle-stimulating hormone (FSH), and AMH in women with papillary thyroid cancer (PTC) treated with RAI. We examined 25 women at a median age of 33 years treated with a single dose of RAI. We divided the p articipants into women over (n = 11) and under 35 years of age (n = 14). Serum concentrations of inhibin B, FSH, AMH, and AFC were assessed at baseline and 1 year after RAI treatmen t. We found decreased AFC (P = 0.03), serum levels of AMH (P < 0.01), inhibin B (P = 0.03), but not FSH (P = 0.23), 1 year after RAI treatment in comparison to baseline in the who le group. When we compared serum levels of AMH in younger vs older women separate ly, we observed a significant reduction of this hormone’s serum level after RAI tr eatment in both groups (P < 0.01; P = 0.04, respectively). We concluded that RAI treatment significan tly impacts the functional ovarian reserve in premenopausal women with PTC.
Published: 2021
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27. Crosstalk between cytotoxic CD8+ T cells and stressed cardiomyocytes triggers development of interstitial cardiac fibrosis in hypertensive mouse hearts

Author: Kurt Brassington, Peter Kanellakis, Anh Cao, Ban-Hock Toh, Karlheinz Peter, Alex Bobik, and Tin Kyaw
Subjects: cardiac fibrosis, CD8+ T cells, perforin, NKG2D, cardiomyocytes, RAE-1, Immunologic diseases. Allergy, RC581-607
Abstract: Graphical AbstractCardiac fibrosis developed from fibrotic remodelling due to hypertension leads to heart failure. Immune cells are abundantly accumulated in fibrotic regions, but exact mechanisms how they contributed to cardiac fibrosis are not clear. Here we demonstrated that CD8 T cells are major contributor to cardiac fibrosis in hypertensive hearts. Stressed cardiomyocytes express STING-dependent RAE-1 that activates NKG2D + CD8 T cells to induce apoptosis of stressed cardiomyocytes. Preventing STING signalling in stressed cardiomyocytes attenuates cardiac fibrosis. Pharmacologically inhibiting cardiomyocayte-RAE-1 and CD8+ T cell-NKG2D axis may be a potential therapeutic strategy to prevent cardiac fibrosis in HFpEF patients.
Published: 2022
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28. Molecular Dynamics Simulations of Selective Metabolite Transport across the Propanediol Bacterial Microcompartment Shell

Author: Park, Jiyong, Chun, Sunny, Bobik, Thomas A, Houk, Kendall N, and Yeates, Todd O
Subjects: Generic health relevance, Aldehydes, Bacterial Proteins, Biological Transport, Hydrogen Bonding, Molecular Dynamics Simulation, Propylene Glycol, Salmonella enterica, Physical Sciences, Chemical Sciences, Engineering
Abstract: Bacterial microcompartments are giant protein-based organelles that encapsulate special metabolic pathways in diverse bacteria. Structural and genetic studies indicate that metabolic substrates enter these microcompartments by passing through the central pores in hexameric assemblies of shell proteins. Limiting the escape of toxic metabolic intermediates created inside the microcompartments would confer a selective advantage for the host organism. Here, we report the first molecular dynamics (MD) simulation studies to analyze small-molecule transport across a microcompartment shell. PduA is a major shell protein in a bacterial microcompartment that metabolizes 1,2-propanediol via a toxic aldehyde intermediate, propionaldehyde. Using both metadynamics and replica-exchange umbrella sampling, we find that the pore of the PduA hexamer has a lower energy barrier for passage of the propanediol substrate compared to the toxic propionaldehyde generated within the microcompartment. The energetic effect is consistent with a lower capacity of a serine side chain, which protrudes into the pore at a point of constriction, to form hydrogen bonds with propionaldehyde relative to the more freely permeable propanediol. The results highlight the importance of molecular diffusion and transport in a new biological context.
Published: 2017

29. Analysis of the Specificity of Auto-Reactive Antibodies to Individual Fragments of the Extracellular Domain of Desmoglein 3 in Patients with Pemphigus Vulgaris

Author: Kubanov, A. A., Deryabin, D. G., Shpilevaya, M. V., Karamova, A. E., Nikonorov, A. A., Larina, E. N., Aliev, T. K., Dolgikh, D. A., Bobik, T. V., Smirnov, I. V., Gabibov, A. G., and Kirpichnikov, M. P.
Published: 2021
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30. Cosmic Rays Propagation with HelMod: Difference between forward-in-time and backward-in-time approaches

Author: Della Torre, S., Bobik, P., Boschini, M. J., Gervasi, M., Grandi, D., La Vacca, G., Pensotti, S., Putis, M., Rancoita, P. G., Rozza, D., Tacconi, M., and Zannoni, M.
Subjects: Physics - Space Physics, Astrophysics - High Energy Astrophysical Phenomena
Abstract: The cosmic rays modulation inside the heliosphere is well described by a transport equation introduced by Parker in 1965. To solve this equation several approaches were followed in the past. Recently the Monte Carlo approach becomes widely used in force of his advantages with respect to other numerical methods. In the Monte Carlo approach, the transport equation is associated to a fully equivalent set of Stochastic Differential Equations. This set is used to describe the stochastic path of a quasi-particle from a source, e.g., the interstellar medium, to a specific target, e.g., a detector at Earth. In this work, we present both the Forward-in-Time and Backward-in-Time Monte Carlo solutions. We present an implementation of both algorithms in the framework of HelMod Code showing that the difference between the two approach is below 5\% that can be quoted as the systematic uncertain of the Method itself., Comment: presented at the The 34th International Cosmic Ray Conference, 30 July- 6 August, 2015, The Hague, The Netherlands
Published: 2015

31. Recombinant Fragment of the Extracellular Domain of Human Desmoglein 3 Fused with the Fc-Fragment of Human IgG1 Selectively Adsorbs Autoreactive Antibodies from the Sera of Pemphigus Patients

Author: Larina, E. N., Karasev, V. S., Shpilevaya, M. V., Aliev, T. K., Bochkova, O. P., Karamova, A. E., Balabashin, D. S., Deryabin, D. G., Bobik, T. V., Smirnov, I. V., Kubanov, A. A., Staroverov, S. M., Gabibov, A. G., and Kirpichnikov, M. P.
Published: 2021
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32. The importance of interpersonal skills in the work of a school counselor

Author: Bogumiła Maria Bobik
Subjects: emotional support, self-disclosure, school counselor, interpersonal skills, relationship initiation, assertive impacts, Social Sciences
Abstract: The main aim of the study was to diagnose interpersonal skills of professionally active school counselors. The research was diagnostic and descriptive. Interpersonal Competence Questionnaire (ICQ-R), compiled by Waldemar Klinkosz, Justyna Iskra and Magdalena Dawidowicz, was used to collect the research material. A diagnosis of five dimensions of interpersonal competences of counselors, necessary for effective functioning in interpersonal relations was made. They were: initiating relationships, assertive interactions, self-disclosure, and emotional support. The analysis of research results indicates that the surveyed counselors are people who are able to initiate relationships, meet people and conduct conversations with them. In relations with others, they are focused on providing emotional support and self-disclosure; they are able to express their opinions and positions. They deal well with the problems and conflicts that they have to solve in the educational environment. They can emphasize their position on important matters, and enforce their rights and clearly express expectations. Their interpersonal skills predispose them to perform the tasks of a school counselor.
Published: 2020
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33. Dihalni premori zaradi nedonošenosti: vzroki, zdravljenje in preprečevanje, posledice ter genetska osnova

Author: Barbara Bobik, Štefan Grosek, and Lilijana Kornhauser Cerar
Subjects: nedonošenost, motnje dihanje, stalni pozitivni tlak v dihalnih poteh, kofein, genetska predispozicija, Medicine
Abstract: Dihalni premori (ali apnoične atake, pavze, apneje) zaradi nedonošenosti so ena najpogosteje postavljenih diagnoz v neonatalnih intenzivnih enotah. Dihalni premori so prehodne narave in nastanejo zaradi motnje v prilagoditvi dihalnega centra in dihal na zunajmaternično življenje ter nezrelosti receptorjev, ki zaznavajo delne tlake kisika in ogljikovega dioksida. Pomembno podaljšujejo trajanje hospitalizacije ter imajo lahko škodljive dolgoročne posledice. V preglednem prispevku opredeljujemo dihalne premore zaradi nedonošenosti. Predstavljamo klasifikacijo, epidemiologijo, patofiziološko ozadje in nadzorovanje srčno-dihalnih funkcij nedonošenčkov. Opisujemo, kako postaviti diagnozo dihalnih premorov zaradi nedonošenosti, sekundarne vzroke apneje in diferencialnodiagnostične možnosti ter nekatera stanja, ki so povezana z dihalnimi premori zaradi nedonošenosti. Velik del prispevka je namenjen predstavitvi možnih terapevtskih ukrepov, med njimi tudi takih, ki še niso prodrli v splošno klinično prakso, saj so za potrditev njihove učinkovitosti potrebne nadaljnje raziskave. Sklepni del članka ponuja pregled raziskav, v katerih so proučevali genetsko podlago dihalnih premorov zaradi nedonošenosti in predstavitev njihovih rezultatov.
Published: 2020
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34. Development of a Serum-Free Media Based on the Optimal Combination of Recombinant Protein Additives and Hydrolysates of Non-animal Origin to Produce Immunoglobulins

Author: Balabashin, D. S., Kaliberda, E. N., Smirnov, I. V., Mokrushina, Y. A., Bobik, T. V., Aliev, T. K., Dolgikh, D. A., and Kirpichnikov, M. P.
Published: 2020
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35. Cosmic Ray Modulation studied with HelMod Monte Carlo tool and comparison with Ulysses Fast Scan Data during consecutive Solar Minima

Author: Bobik, P., Boella, G., Boschini, M. J., Della Torre, S., Gervasi, M., Grandi, D., La Vacca, G., Kudela, K., Pensotti, S., Rancoita, P. G., Rozza, D., and Tacconi, M.
Subjects: Astrophysics - Earth and Planetary Astrophysics, Astrophysics - Solar and Stellar Astrophysics, Physics - Space Physics
Abstract: The Cosmic Rays propagation was studied in details using the HelMod-2D Monte Carlo code, that includes a general description of the diffusion tensor, and polar magnetic-field. The Numerical Approach used in this work is based on a set of Stochastic Differential Equations fully equivalent to the well know Parker Equation for the transport of Cosmic Rays. In our approach the Diffusion tensor in the frame of the magnetic field turbolence does not depends explicitly by Solar Latitude but varies with time using a diffusion parameter obtained by Neutron Monitors. The parameters of the Model were tuned using data during the solar Cycle 23 and Ulysses latitudinal Fast Scan in 1995. The actual parametrization is able to well reproduce the observed latitudinal gradient of protons and the southward shift of the minimum of latitudinal intensity. The description of the model is also available online at website www.helmod.org. The model was then applied on Pamela/Ulysses proton intensity from 2006 up to 2009. The model during this 4-year continous period agree well with both PAMELA (at 1 AU) and Ulysses data (at various solar distance and solar latitude). The agreement improves when considering the ratio between this data. Studies done also with particles with different charge (e.g. electrons) allow us to explain the presence (or not) of protons and electrons latitudinal gradients observed by Ulysses during the Latitudinal Fast Scan in 1995 and 2007.
Published: 2013

36. GeoMag and HelMod webmodels version for magnetosphere and heliosphere transport of cosmic rays

Author: Bobik, P., Boschini, M. J., Consolandi, C., Della Torre, S., Gervasi, M., Grandi, D., Kudela, K., La Vacca, G., Pensotti, S., Putis, M., Rancoita, P. G., Rozza, D., and Tacconi, M.
Subjects: Astrophysics - Instrumentation and Methods for Astrophysics, Astrophysics - Earth and Planetary Astrophysics, Astrophysics - Solar and Stellar Astrophysics
Abstract: We implemented a website to deal with main effects on Cosmic Ray access to the Earth, i.e. the Solar Modulation and the Geomagnetic Field effect. In helmod.org the end user can easily access a web interface to results catalog of the HelMod Monte Carlo Code. This Model uses a Monte Carlo Approach to solves the Parker Transport Equation, obtaining a modulated proton flux for a period (monthly average) between January 1990 and december 2007. geomagsphere.org is instead based on GeoMag Backtracing Code, that solves the Lorentz equation with a Runge-Kutta method of 6th order, and, reversing charge sign and velocity, reconstruct particle trajectories in the Earth Magnetosphere back in time. We use last models of internal (IGRF-11) and external (Tsyganenko 1996 -T96- and 2005 -T05-) field components valid up to 2015. Particles are backtraced to the outer (magnetopause) or inner boundary to separate Primary (allowed trajectory) from Secondary (forbidden) Cosmic Rays. This code has been used both for reproducing known effects as East-West effect and rigidity cutoff calculations. In geomagsphere.org the user can choose the external field model from Tsyganenko (T96 or T05) and obtain for a fixed position and date from 1st Jan. 1968 (T96) and 1st Jan. 1995 (T05) respectively till 31$^{st}$ Dec 2012, the vertical rigidity cutoff estimation obtained with the backtracing technique with a rigidity step of 0.1 GV. For a more precise calculation (0.01 GV), requiring more CPU time, results are sent to the user by email (mail model)
Published: 2013

37. Suprathermal particle addition to solar wind pressure: possible influence on magnetospheric transmissivity of low energy cosmic rays?

Author: Bobik, P., Boschini, M. J., Consolandi, C., Della Torre, S., Gervasi, M., Grandi, D., Kudela, K., La Vacca, G., Mallamaci, M., Pensotti, S., Rancoita, P. G., Rozza, D., and Tacconi, M.
Subjects: Astrophysics - Instrumentation and Methods for Astrophysics, Astrophysics - Earth and Planetary Astrophysics, Astrophysics - Solar and Stellar Astrophysics, Physics - Space Physics
Abstract: Energetic (suprathermal) solar particles, accelerated in the interplanetary medium, contribute to the solar wind pressure, in particular during high solar activity periods. We estimated the effect of the increase of solar wind pressure due to suprathermal particles on magnetospheric transmissivity of galactic cosmic rays in the case of one recent solar event.
Published: 2013

38. An evaluation of the exposure in nadir observation of the JEM-EUSO mission

Author: Adams, J. H., Ahmad, S., Albert, J. -N., Allard, D., Ambrosio, M., Anchordoqui, L., Anzalone, A., Arai, Y., Aramo, C., Asano, K., Ave, M., Barrillon, P., Batsch, T., Bayer, J., Belenguer, T., Bellotti, R., Berlind, A. A., Bertaina, M., Biermann, P. L., Biktemerova, S., Blaksley, C., Blecki, J., Blin-Bondil, S., Bluemer, J., Bobik, P., Bogomilov, M., Bonamente, M., Briggs, M. S., Briz, S., Bruno, A., Cafagna, F., Campana, D., Capdevielle, J-N., Caruso, R., Casolino, M., Cassardo, C., Castellini, G., Catalano, O., Cellino, A., Chikawa, M., Christl, M. J., Connaughton, V., Cortes, J. F., Crawford, H. J., Cremonini, R., Csorna, S., D'Olivo, J. C., Dagoret-Campagne, S., de Castro, A. J., De Donato, C., de la Taille, C., del Peral, L., Dell'Oro, A., De Pascale, M. P., Di Martino, M., Distratis, G., Dupieux, M., Ebersoldt, A., Ebisuzaki, T., Engel, R., Falk, S., Fang, K., Fenu, F., Fernandez-Gomez, I., Ferrarese, S., Franceschi, A., Fujimoto, J., Galeotti, P., Garipov, G., Geary, J., Giaccari, U. G., Giraudo, G., Gonchar, M., Alvarado, C. Gonzalez, Gorodetzky, P., Guarino, F., Guzman, A., Hachisu, Y., Harlov, B., Haungs, A., Carretero, J. Hernandez, Higashide, K., Iguchi, T., Ikeda, H., Inoue, N., Inoue, S., Insolia, A., Isgrio, F., Itow, Y., Joven, E., Judd, E. G., Jung, A., Kajino, F., Kajino, T., Kaneko, I., Karadzhov, Y., Karczmarczyk, J., Katahira, K., Kawai, K., Kawasaki, Y., Keilhauer, B., Khrenov, B. A., Kim, Jeong-Sook, Kim, Soon-Wook, Kim, Sug-Whan, Kleifges, M., Klimov, P. A., Ko, S. H., Kolev, D., Kreykenbohm, I., Kudela, K., Kurihara, Y., Kuznetsov, E., La Rosa, G., Lee, J., Licandro, J., Lim, H., Lopez, F., Maccarone, M. C., Mannheim, K., Marcelli, L., Marini, A., Martin-Chassard, G., Martinez, O., Masciantonio, G., Mase, K., Matev, R., Maurissen, A., Medina-Tanco, G., Mernik, T., Miyamoto, H., Miyazaki, Y., Mizumoto, Y., Modestino, G., Monnier-Ragaigne, D., Rios, J. A. Morales de los, Mot, B., Murakami, T., Nagano, M., Nagata, M., Nagataki, S., Nakamura, T., Nam, J. W., Nam, S., Nam, K., Napolitano, T., Naumov, D., Neronov, A., Nomoto, K., Ogawa, T., Ohmori, H., Olinto, A. V., Orleanski, P., Osteria, G., Pacheco, N., Panasyuk, M. I., Parizot, E., Park, I. H., Pastircak, B., Patzak, T., Paul, T., Pennypacker, C., Peter, T., Picozza, P., Pollini, A., Prieto, H., Reardon, P., Reina, M., Reyes, M., Ricci, M., Rodriguez, I., Frias, M. D. Rodriguez, Ronga, F., Rothkaehl, H., Roudil, G., Rusinov, I., Rybczynski, M., Sabau, M. D., Cano, G. Saez, Saito, A., Sakaki, N., Sakata, M., Salazar, H., Sanchez, S., Santangelo, A., Cruz, L. Santiago, Palomino, M. Sanz, Saprykin, O., Sarazin, F., Sato, H., Sato, M., Schanz, T., Schieler, H., Scotti, V., Scuderi, M., Segreto, A., Selmane, S., Semikoz, D., Serra, M., Sharakin, S., Shibata, T., Shimizu, H. M., Shinozaki, K., Shirahama, T., Siemieniec-Ozieb, G., Lopez, H. H. Silva, Sledd, J., Slominska, K., Sobey, A., Sugiyama, T., Supanitsky, D., Suzuki, M., Szabelska, B., Szabelski, J., Tajima, F., Tajima, N., Tajima, T., Takahashi, Y., Takami, H., Takeda, M., Takizawa, Y., Tenzer, C., Tibolla, O., Tkachev, L., Tomida, T., Tone, N., Trillaud, F., Tsenov, R., Tsuno, K., Tymieniecka, T., Uchihori, Y., Vaduvescu, O., Valdes-Galicia, J. F., Vallania, P., Valore, L., Vankova, G., Vigorito, C., Villasenor, L., von Ballmoos, P., Wada, S., Watanabe, J., Watanabe, S., Watts, J., Weber, M., Weiler, T. J., Wibig, T., Wiencke, L., Wille, M., Wilms, J., Wlodarczyk, Z., Yamamoto, T., Yamamoto, Y., Yang, J., Yano, H., Yashin, I. V., Yonetoku, D., Yoshida, K., Yoshida, S., Young, R., Zamora, A., and Marchi, A. Zuccaro
Subjects: Astrophysics - High Energy Astrophysical Phenomena, Astrophysics - Instrumentation and Methods for Astrophysics
Abstract: We evaluate the exposure during nadir observations with JEM-EUSO, the Extreme Universe Space Observatory, on-board the Japanese Experiment Module of the International Space Station. Designed as a mission to explore the extreme energy Universe from space, JEM-EUSO will monitor the Earth's nighttime atmosphere to record the ultraviolet light from tracks generated by extensive air showers initiated by ultra-high energy cosmic rays. In the present work, we discuss the particularities of space-based observation and we compute the annual exposure in nadir observation. The results are based on studies of the expected trigger aperture and observational duty cycle, as well as, on the investigations of the effects of clouds and different types of background light. We show that the annual exposure is about one order of magnitude higher than those of the presently operating ground-based observatories., Comment: published in Astroparticle Physics by the JEM-EUSO Collaboration
Published: 2013
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39. Banco Interamericano de Desenvolvimento (BID) no espaço-tempo: uma análise crítica sobre seu papel no financiamento da integração regional

Author: José Alex Rego Soares and Márcio Bobik Braga
Subjects: Exclusão Financeira, BID, Integração Regional, Crédito, Renda, Human ecology. Anthropogeography, GF1-900, Physical geography, GB3-5030, Geography (General), G1-922
Abstract: O objetivo do artigo consiste em analisar a desempenho do BID enquanto banco de integração regional e o tratamento dispensado ao circulo vicioso crédito-renda no período de sua criação até o começo do século XX. Dadas as circunstâncias comumente apresentadas em regiões com alta desigualdade de renda, a promoção do crédito fica presa nesse circuito vicioso, pois só há acesso ao crédito quem possui renda. Assim sendo, problematizamos como o Banco Interamericano não foi capaz de se consolidar como uma instituição financeira internacional de primeira linha no Sistema Financeiro Mundial (SFM). O BID tampouco ocupa o espaço de agente facilitador da integração regional na acepção da compactação entre espaço e tempo como dinamizador do crédito, uma vez que o desenho institucional do BID impossibilita o crédito no processo de integração regional.
Published: 2021
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40. JEM-EUSO experiment for extreme energy cosmic ray observation

Author: Pastirčák, Blahoslav, Bobík, Pavol, and Kudela, Karel
Subjects: Astrophysics - Instrumentation and Methods for Astrophysics, Astrophysics - High Energy Astrophysical Phenomena, Physics - Space Physics
Abstract: The planned JEM-EUSO (Extreme Universe Space Observatory onboard the ISS Japanese Experimental Module) will measure the energy spectra of cosmic rays up to the range of 1000 EeV and will search for direction to their sources. It will observe the extensive air showers generated in the atmosphere by high energy cosmic ray primary particle from the space. The instantaneous aperture of the telescope will exceed by one order the aperture of the largest ground based detectors. JEM-EUSO apparatus is a large telescope with a diameter of 2.5 m with fast UV camera. Slovakia is responsible for the determination of the UV background, which influences the operational efficiency of the experiment and for the analysis of fake trigger events., Comment: Physics in Collision, Slovakia, 2012
Published: 2012

41. Latitudinal Dependence of Cosmic Rays Modulation at 1 AU and Interplanetary-Magnetic-Field Polar Correction

Author: Bobik, P., Boella, G., Boschini, M. J., Consolandi, C., Della Torre, S., Gervasi, M., Grandi, D., Kudela, K., Pensotti, S., Rancoita, P. G., Rozza, D., and Tacconi, M.
Subjects: Astrophysics - Solar and Stellar Astrophysics, Astrophysics - Cosmology and Nongalactic Astrophysics, Astrophysics - Earth and Planetary Astrophysics, Astrophysics - Astrophysics of Galaxies
Abstract: The cosmic rays differential intensity inside the heliosphere, for energy below 30 GeV/nuc, depends on solar activity and interplanetary magnetic field polarity. This variation, termed solar modulation, is described using a 2-D (radius and colatitude) Monte Carlo approach for solving the Parker transport equation that includes diffusion, convection, magnetic drift and adiabatic energy loss. Since the whole transport is strongly related to the interplanetary magnetic field (IMF) structure, a better understanding of his description is needed in order to reproduce the cosmic rays intensity at the Earth, as well as outside the ecliptic plane. In this work an interplanetary magnetic field model including the standard description on ecliptic region and a polar correction is presented. This treatment of the IMF, implemented in the HelMod Monte Carlo code (version 2.0), was used to determine the effects on the differential intensity of Proton at 1\,AU and allowed one to investigate how latitudinal gradients of proton intensities, observed in the inner heliosphere with the Ulysses spacecraft during 1995, can be affected by the modification of the IMF in the polar regions., Comment: accepted for publication inAdvances in Astronomy
Published: 2012
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42. Poly(sodium acrylate)-Modified Magnetite Nanoparticles for Separation of Heavy Metals from Aqueous Solutions

Author: Magdalena Bobik, Irena Korus, Karol Synoradzki, Jacek Wojnarowicz, Dorota Biniaś, and Włodzimierz Biniaś
Subjects: magnetic iron oxides, poly(sodium acrylate), nanoparticles, adsorption, heavy metals, Technology, Electrical engineering. Electronics. Nuclear engineering, TK1-9971, Engineering (General). Civil engineering (General), TA1-2040, Microscopy, QH201-278.5, Descriptive and experimental mechanics, QC120-168.85
Abstract: Two types of magnetite nanoparticles: unmodified (Fe3O4 NPs), and modified with poly(sodium acrylate) (Fe3O4/PSA NPs) were synthesized by the co-precipitation method and characterized using different techniques: X-ray diffraction (XRD), transmission electron microscopy (TEM), nanoparticle tracking analysis (NTA), Brunauer–Emmett–Teller (BET) adsorption, Fourier-transform infrared spectroscopy (FTIR). Additionally, magnetic properties and the effect of pH on the zeta potential were analyzed for both types of nanoparticles. Magnetites were used as adsorbents for seven heavy metal ions (Zn(II), Cu(II), Ni(II), Cd(II), Pb(II), Cr(III), Cr(VI)) within the pH range of 3–7. Research revealed nanometric particle sizes, a specific surface area of 140–145 m2/g, and superparamagnetic properties of both tested materials. Moreover, the presence of PSA functional groups in modified magnetite was confirmed, which lowered the pH of the isoelectric point. Both types of magnetite were effective metal ion adsorbents, with metal cations more effectively removed on Fe3O4/PSA NPs and Cr(VI) anions on Fe3O4 NPs. The adsorption of most of the examined cations (performed at pH = 5) can be well described by the Langmuir isotherm model, whereas the adsorption of Cr(VI) ions on modified magnetite correlated better with the Freundlich model. The Dubinin–Radushkevich model confirmed that chemisorption is the predominant process. The adsorption of all metal ions was well-characterized by the pseudo-second-order kinetic model.
Published: 2022
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43. The JEM-EUSO Mission: Status and Prospects in 2011

Author: Collaboration, The JEM-EUSO, Adams Jr, J. H., Ahmad, S., Albert, J. -N., Allard, D., Ambrosio, M., Anchordoqui, L., Anzalone, A., Arai, Y., Aramo, C., Asano, K., Barrillon, P., Batsch, T., Bayer, J., Belenguer, T., Bellotti, R., Berlind, A. A., Bertaina, M., Biermann, P. L., Biktemerova, S., Blaksley, C., Blecki, J., Blin-Bondil, S., Bluemer, J., Bobik, P., Bogomilov, M., Bonamente, M., Briggs, M. S., Briz, S., Bruno, A., Cafagna, F., Campana, D., Capdevielle, J-N., Caruso, R., Casolino, M., Cassardo, C., Castellini, G., Catalano, O., Cellino, A., Chikawa, M., Christl, M. J., Connaughton, V., Cortes, J. F., Crawford, H. J., Cremonini, R., Csorna, S., D'Olivo, J. C., Dagoret-Campagne, S., de Castro, A. J., De Donato, C., de la Taille, C., De Pascale, M. P., del Peral, L., Dell'Oro, A., Di Martino, M., Distrati, G., Dupieux, M., Ebersoldt, A., Ebisuzaki, T., Engel, R., Falk, S., Fang, K., Fenu, F., Ferrarese, S., Fernandez-Gomez, I., Franceschi, A., Fujimoto, J., Galeotti, P., Garipov, G., Geary, J., Giaccari, U. G., Giraudo, G., Gonchar, M., Alvarado, C. Gonzalez, Gorodetzky, P., Guarino, F., Guzman, A., Hachisu, Y., Harlov, B., Haungs, A., Carretero, J. Hernandez, Higashide, K., Iguchi, T., Ikeda, H., Inoue, N., Inoue, S., Insolia, A., Isgro, F., Itow, Y., Joven, E., Judd, E. G., Jung, A., Kajino, F., Kajino, T., Kaneko, I., Karadzhov, Y., Karczmarczyk, J., Katahira, K., Kawai, K., Kawasaki, Y., Keilhauer, B., Khrenov, B. A., Kim, Jeong-Sook, Kim, Soon-Wook, Kim, Sug-Whan, Kleifges, M., Klimov, P. A., Ko, S. H., Kolev, D., Kreykenbohm, I., Kudela, K., Kurihara, Y., Kuznetsov, E., La Rosa, G., Lee, J., Licandro, J., Lim, H., Lopez, F., Maccarone, M. C., Marcelli, L., Marini, A., Martin-Chassard, G., Martinez, O., Masciantonio, G., Mase, K., Matev, R., Maurissen, A., Medina-Tanco, G., Mernik, T., Miyamoto, H., Miyazaki, Y., Mizumoto, Y., Modestino, G., Monnier-Ragaigne, D., Rıos, J. A. Morales de los, Mot, B., Murakami, T., Nagano, M., Nagata, M., Nagataki, S., Nam, J. W., Nam, S., Nam, K., Napolitano, T., Naumov, D., Neronov, A., Nomoto, K., Ogawa, T., Ohmori, H., Olinto, A. V., Orleanski, P., Osteria, G., Pacheco, N., Panasyuk, M. I., Parizot, E., Park, I. H., Pastircak, B., Patzak, T., Paul, T., Pennypacker, C., Peter, T., Picozza, P., Pollini, A., Prieto, H., Reardon, P., Reina, M., Reyes, M., Ricci, M., Rodrıguez, I., Frıas, M. D. Rodrıguez, Ronga, F., Rothkaehl, H., Roudil, G., Rusinov, I., Rybczynski, M., Sabau, M. D., Cano, G. Saez, Saito, A., Sakaki, N., Sakata, M., Salazar, H., Sanchez, S., Santangelo, A., Cruz, L. Santiago, Palomino, M. Sanz, Saprykin, O., Sarazin, F., Sato, H., Sato, M., Schanz, T., Schieler, H., Scotti, V., Scuderi, M., Segreto, A., Selmane, S., Semikoz, D., Serra, M., Sharakin, S., Shibata, T., Shimizu, H. M., Shinozaki, K., Shirahama, T., Siemieniec-Ozieblo, G., Lopez, H. H. Silva, Sledd, J., Slominska, K., Sobey, A., Sugiyama, T., Supanitsky, D., Suzuki, M., Szabelska, B., Szabelski, J., Tajima, F., Tajima, N., Tajima, T., Takami, H., Nakamura, T., Takeda, M., Takahashi, Y., Takizawa, Y., Tenzer, C., Tkachev, L., Tomida, T., Tone, N., Trillaud, F., Tsenov, R., Tsuno, K., Tymieniecka, T., Uchihori, Y., Vaduvescu, O., Valdes-Galicia, J. F., Vallania, P., Valore, L., Vankova, G., Vigorito, C., Villasenor, L., von Ballmoos, P., Wada, S., Watanabe, J., Watanabe, S., Watts Jr, J., Weber, M., Weiler, T. J., Wibig, T., Wiencke, L., Wille, M., Wilms, J., Wlodarczyk, Z., Yamamoto, T., Yamamoto, Y., Yang, J., Yano, H., Yashin, I. V., Yonetoku, D., Yoshida, K., Yoshida, S., Young, R., Zamora, A., and Marchi, A. Zuccaro
Subjects: Astrophysics - Instrumentation and Methods for Astrophysics, Astrophysics - High Energy Astrophysical Phenomena
Abstract: Contributions of the JEM-EUSO Collaboration to the 32nd International Cosmic Ray Conference, Beijing, August, 2011., Comment: 33 contributions plus index
Published: 2012

44. Heliosphere Dimension and Cosmic Ray Modulation

Author: Bobik, P., Boschini, M. J., Consolandi, C., Della Torre, S., Gervasi, M., Grandi, D., Kudela, K., Noventa, F., Pensotti, S., Rancoita, P. G., and Rozza, D.
Subjects: Astrophysics - Solar and Stellar Astrophysics, Astrophysics - Earth and Planetary Astrophysics
Abstract: The differential intensities of Cosmic Rays at Earth were calculated using a 2D stochastic Montecarlo diffusion code and compared with observation data. We evaluated the effect of stretched and compressed heliospheres on the Cosmic Ray intensities at the Earth. This was studied introducing a dependence of the diffusion parameter on the heliospherical size. Then, we found that the optimum value of the heliospherical radius better accounting for experimental data. We also found that the obtained values depends on solar activity. Our results are compatible with Voyager observations and with models of heliospherical size modulation., Comment: To appear on the Proceedings of the 13th ICATPP Conference on Astroparticle, Particle, Space Physics and Detectors for Physics Applications, Villa Olmo (Como, Italy), 3-7 October, 2011, to be published by World Scientific, Singapore (2012)
Published: 2011
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45. Systematic Investigation of Solar Modulation of Galactic Protons for Solar Cycle 23 using a Monte Carlo Approach with Particle Drift Effects and Latitudinal Dependence

Author: Bobik, P., Boella, G., Boschini, M. J., Consolandi, C., Della Torre, S., Gervasi, M., Grandi, D., Kudela, K., Pensotti, S., Rancoita, P. G., and Tacconi, M.
Subjects: Astrophysics - Solar and Stellar Astrophysics, Astrophysics - Earth and Planetary Astrophysics
Abstract: A propagation model of galactic cosmic protons through the Heliosphere was implemented using a 2-D Monte Carlo approach to determine the differential intensities of protons during the solar cycle 23. The model includes the effects due to the variation of solar activity during the propagation of cosmic rays from the boundary of the heliopause down to Earth's position. Drift effects are also accounted for. The simulated spectra were found in agreement with those obtained with experimental observations carried out by BESS, AMS and PAMELA collaborations. In addition, the modulated spectrum determined with the present code for the year 1995 exhibits the latitudinal gradient and equatorial southward offset minimum found by Ulysses fast scan in 1995., Comment: accepted for publication on The Astrophysical Journal
Published: 2011
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46. Antiproton modulation in the Heliosphere and AMS-02 antiproton over proton ratio prediction

Author: Bobik, P., Boschini, M. J., Consolandi, C., Della Torre, S., Gervasi, M., Grandi, D., Kudela, K., Pensotti, S., and Rancoita, P. G.
Subjects: Astrophysics - Earth and Planetary Astrophysics
Abstract: We implemented a quasi time-dependent 2D stochastic model of solar modulation describing the transport of cosmic rays (CR) in the heliosphere. Our code can modulate the Local Interstellar Spectrum (LIS) of a generic charged particle (light cosmic ions and electrons), calculating the spectrum at 1AU. Several measurements of CR antiparticles have been performed. Here we focused our attention on the CR antiproton component and the antiproton over proton ratio. We show that our model, using the same heliospheric parameters for both particles, fit the observed anti-p/p ratio. We show a good agreement with BESS-97 and PAMELA data and make a prediction for the AMS-02 experiment.
Published: 2011
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47. Proton and antiproton modulation in the heliosphere for different solar conditions and AMS-02 measurements prediction

Author: Bobik, P., Boschini, M. J., Consolandi, C., Della Torre, S., Gervasi, M., Grandi, D., Kudela, K., Pensotti, S., and Rancoita, P. G.
Subjects: Astrophysics - Earth and Planetary Astrophysics
Abstract: Galactic Cosmic Rays (GCRs) are mainly protons confined in the galactic magnetic field to form an isotropic flux inside the galaxy. Before reaching the Earth orbit they enter the Heliosphere and undergo diffusion, convection, magnetic drift and adiabatic energy loss. The result is a reduction of particles flux at low energy (below 10 GeV), called solar modulation. We realized a quasi time-dependent 2D Stochastic Simulation of Solar Modulation that is able to reproduce CR spectra once known the Local Interstellar Spectrum (LIS). We were able to estimate the different behaviors associated to the polarity dependence of the Heliospheric modulation for particles as well as for antiparticles. We show a good agreement with the antiproton/proton ratio measured by AMS-01, Pamela, BESS, Heat and Caprice and we performed a prediction for the AMS-02 Experiment.
Published: 2010
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48. Proton Modulation in the Heliosphere for Different Solar Conditions and Prediction for AMS-02

Author: Bobik, P., Boella, G., Boschini, M. J., Consolandi, C., Della Torre, S., Gervasi, M., Grandi, D., Kudela, K., Memola, E., Pensotti, S., Rancoita, P. G., and Tacconi, M.
Subjects: Astrophysics - Earth and Planetary Astrophysics
Abstract: Spectra of Galactic Cosmic Rays (GCRs) measured at the Earth are the combination of several processes: sources production and acceleration, propagation in the interstellar medium and propagation in the heliosphere. Inside the solar cavity the flux of GCRs is reduced due to the solar modulation, the interaction which they have with the interplanetary medium. We realized a 2D stochastic simulation of solar modulation to reproduce CR spectra at the Earth, and evaluated the importance in our results of the Local Interstellar Spectrum (LIS) model and its agreement with data at high energy. We show a good agreement between our model and the data taken by AMS-01 and BESS experiments during periods with different solar activity conditions. Furthermore we made a prediction for the flux which will be measured by AMS-02 experiment., Comment: Accepted for publication in the Proceedings of the ICATPP Conference on Cosmic Rays for Particle and Astroparticle Physics, Villa Olmo (Como, Italy), 7-8 October, 2010, to be published by World Scientific (Singapore)
Published: 2010
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49. Electron and Positron solar modulation and prediction for AMS-02

Author: Bobik, P., Boschini, M. J., Consolandi, C., Della Torre, S., Gervasi, M., Grandi, D., Kudela, K., Pensotti, S., and Rancoita, P. G.
Subjects: Astrophysics - Solar and Stellar Astrophysics
Abstract: The solar modulation, a combination of diffusion, convection, magnetic drift and energy loss inside the heliosphere is usually seen as a depletion in the Galactic cosmic ray (CR) flux at low energy (less than 10 GeV/nuc). Antiparticles such as antiprotons or positrons undergo the same processes of respective particles but with a different magnitude depending on the Solar magnetic field polarity. For electrons and positrons, due to the small mass, energy loss mechanisms as inverse compton, synchrotron, bremsstrahlung and ionization have to be taken into account, together with the typical adiabatic losses considered in the heliosphere. We developed a Monte Carlo stochastic simulation with the aim to compare the solar modulation of particles and antiparticles in the same observation period. We are able to estimate the different behaviours associated to the charge sign dependent processes of the heliospheric modulation. We compared the simulated positron fraction with measurements performed by AMS-01 and PAMELA. We also present the prediction for the AMS-02 experiment., Comment: Accepted for publication in the Proceedings of the ICATPP Conference on Cosmic Rays for Particle and Astroparticle Physics, Villa Olmo (Como, Italy), 7--8 October, 2010, to be published by World Scientific
Published: 2010
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50. Work Conditions and Tasks of School Counsellor

Author: Bogumiła Maria Bobik
Subjects: working conditions, school counsellor, diagnostic testing verification, counsellor's task, forms of psychological and pedagogical help, Social Sciences
Abstract: Objectives The main aim of the research was to become acquainted with the conditions of work and the tasks of the school counsellor resulting from the psychological and pedagogical help performed at educational facilities. Material and methods The following two methods were used to obtain the research material: the diagnostic survey and assessment. Results The results of quantitative analyses were classified into the following areas: the conditions of work, the school counsellor’s duties, the forms of pedagogical help in their work with the students, parents and teachers, the factors that influence the school counsellor’s model of work and individual features important in the profession of school counsellor. The mentioned analyses indicate that the contemporary counsellor is mainly a woman (the profession is feminised), with higher education, systematically improving and supplementing their knowledge so as to perform the tasks set by the pedagogical supervision and family, school and local environment. Conclusions Thanks to adequate professional preparation and application of a wide range of forms of help for the students, teacher and parents, the school counsellor constitutes a significant link of psychological and pedagogical help performed at the educational facilities.
Published: 2019
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