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Rationale & Objective: Providing fruits and vegetables (F&Vs) to health care system patients with elevated urine albumin-creatinine ratio (ACR) reduced ACR, slowed chronic kidney disease (CKD) progression and reduced cardiovascular disease (CVD) risk factors in previous studies. This study evaluated a community-based strategy in lower-income populations to identify African Americans with elevated ACR before health care system involvement and sustain them in a 6-month F&V protocol with (F&V + Cook) and without (F&V Only) cooking instructions, with the hypothesis that adjuvant cooking instructions with F&Vs would further reduce ACR., Study Design: Prospective, randomized, parallel 2-arm design., Setting & Participants: African American adults with ACR >10 mg/g creatinine randomized to 1 of 2 study arms., Interventions: Two cups/day of F&Vs with or without cooking instructions in participants followed 6 months., Outcomes: Participants sustaining the F&V protocol and between-group indicators of CVD risk, kidney injury, and dietary intake at 6 weeks and 6 months., Results: A total of 142 African American adults (mean age, 57.0 years; ACR, 27.4 mg/g; body mass index, 34.4; 24.9% CKD 1; 24.8% CKD 2; 50.4% CKD 3; 55% female) randomized to F&V Only (n=72) or F&V + Cook (n=70), and 71% were retained at 6 months. Participants received 90% of available F&V pick-ups over 6 weeks and 69% over 6 months. In the adjusted model, 6-month ACR was 31% lower for F&V + Cook than F&V Only ( P  = 0.02). Net 6-week F&V intake significantly increased and biometric variables improved for participants combined into a single group., Limitations: Small sample size, low-baseline ACR, and potential nonresponse bias for 24-hour dietary recall measure., Conclusions: These data support the feasibility of identifying community-dwelling African Americans with ACR indicating elevated CVD and CKD risk and sustaining a F&V protocol shown to improve kidney outcomes and CVD risk factors and provides preliminary evidence that cooking instructions adjuvant to F&Vs are needed to lower ACR., Funding: National Institute on Diabetes, Digestive, and Kidney Diseases grant "Reducing chronic kidney disease burden in an underserved population" (R21DK113440)., Trial Registration: NCT03832166., Plain-Language Summary: African Americans, particularly those in low-income communities, have increased rates of chronic kidney disease (CKD) with worsening outcomes over time. Giving fruits and vegetables to individuals with CKD identified in health care systems was previously shown to reduce kidney damage, measured by urine protein albumin, and slow kidney function decline. We recruited African Americans in low-income communities with increased urine albumin levels. They received fruits and vegetables for 6 months, and we tested whether added cooking instructions further reduced urine albumin levels. Most participants continued to receive fruits and vegetables throughout the 6 months. Those given cooking instructions had lower urine albumin levels after 6 months, indicating decreased kidney damage. Providing cooking instructions with fruits and vegetables appears to lessen kidney damage more than just fruits and vegetables alone., (© 2023 Published by Elsevier Inc. on behalf of the National Kidney Foundation, Inc.)

The Comprehensive Care Initiative (CCI) utilized a quasi-experimental design to evaluate the effects of same room, multi-provider primary care visits on the management of type 2 diabetes (T2D). Patients with T2D were invited to enroll in CCI if they had T2D with glycated hemoglobin (HbA1c) >8.0% or T2D with BMI >30. CCI intervention included delivery of comprehensive same room multi-provider visits with a primary care physician, community health worker, pharmacist, dietitian, medical assistant, and licensed social worker at the same appointment. CCI patients were compared with a propensity score matched control group receiving usual care (n = 56, 50 ± 11 years old, 77% female, 41% African American, 95% uninsured). After 6 months, the adjusted average reduction in HbA1c in the CCI group was 0.97% (SE = 0.45) in comparison to 0.05% (SE = 0.20) in the control group ( P  = .04). This pilot study showed promising results in lowering HbA1c in an uninsured, ethnic minority population of T2D patients through delivery of comprehensive multi-provider primary care visits.

We report here a novel multiplexed DNA analysis system consisting of 20 Alu markers and Amelogenin for analysis of highly degraded forensic biological samples. The key to the success of the system in obtaining results from degraded samples is the primer design yielding small amplicon size (60-125bp) for all 20 markers. The markers included in the InnoTyper ® 21 system are bi-allelic, having two possible allelic states (insertion or null) and thus termed INNULs. The markers are short interspersed nuclear elements (SINEs), a category of retrotransposable elements (REs) which are non-coding genomic DNA repeat sequences, or "mobile insertion elements," comprising approximately 40% of the human genome. Alu elements are primate specific SINEs that have reached a copy number in excess of one million in the human genome, which makes these markers highly sensitive and desirable for forensic samples with extremely degraded DNA. Until now however, due to the inherent size difference associated with insertion and no insertion alleles, the use of Alu REs has not been practical for forensic applications. The novel primer design described herein has allowed the development of a multiplexed Alu system yielding fragment sizes amenable to degraded DNA samples, as frequently encountered in missing persons cases or forensic samples such as hair shafts. Although use of Alus in human identity has been studied using single marker amplification and reported before, we report for the first time development and validation of a system with multiplexed RE markers. Studies performed include PCR optimization, species specificity, sensitivity, degradation and inhibition, precision and accuracy, nonprobative samples, mixture, and population database studies. A population study using 592 samples including five populations was performed using InnoTyper 21. The data indicated the random match probability for the combination of these 20 Alu markers was greater than 1 in 3.8 million for the populations studied, indicating the greater statistical power of these autosomal nuclear DNA markers over haplotype systems typically used in such degraded samples. Results demonstrate the system is successful in obtaining results from highly degraded DNA. A sensitivity study performed demonstrated at least 95% recovery of alleles from as low as 50pg of total input DNA, and partial profiles from as low as 25pg. This study has demonstrated that the bi-allelic INNULs in the InnoTyper 21 system provide a sensitivity of detection and a power of discrimination that makes them useful for human identification of extremely degraded samples., (Copyright © 2017 Elsevier B.V. All rights reserved.)

How do Americans' core beliefs about punishment, and their intuitions about which actors deserve blame, shape attitudes toward the use of force against a hostile state? I apply insights from recent work in social psychology to investigate the causal mechanisms linking punitive beliefs to support for a nuclear strike. In a large- N study, I find that the strength and ethical logic underlying beliefs about punishment affect attitudes regarding the use of nuclear weapons, and who to blame for the crisis, which mediates the causal pathway. Those who ground their support for severe punishment not in the logic of moral justice, but in societal benefit, are more likely to hold foreign citizens socially responsible for their state's actions. [ABSTRACT FROM AUTHOR]

While international historians and policy practitioners regularly highlight the utility of multilateral diplomacy as a quintessential "strategy of the weak," International Relations (IR) scholars have generally downplayed the impact of diplomatic choices. The tools within IR theory to assess the impact of diplomacy remain underdeveloped, contributing to an inability to account for a highly proximate source of international influence. This article argues for a theoretical reengagement with the subject of multilateral diplomacy and, using insights from Social Network Analysis, develops a Diplomatic Impact Framework. Building on the novel concept of replaceability, the article contributes theoretically to the literature on diplomacy, as well as on small and middle powers. This framework captures the fundamentally relational character of diplomacy, isolating analytically this form of structural power from the influence conferred by superior material or institutional resources. Drawing extensively on a multinational collection of diplomatic documents and first-hand accounts, this multidisciplinary article probes the plausibility of the framework through a detailed comparative case study of Canada's diplomatic influence at the United Nations General Assembly throughout two international security crises: the Korean War and the Suez Crisis. [ABSTRACT FROM AUTHOR]

This article explores how weak countries deflect systemic pressure towards change and even succeed in preserving old institutions to their advantage. By expanding Goddard's theory of embedded revisionism to smaller powers, the study identifies strategies these states deploy to improve access and brokerage. We use the UN General Assembly Sponsorship Dataset to locate multilateral brokers and, after detecting Cuba's centrality in this arena, we proceed to a heuristic case study. Havana's maneuvers to offset its vulnerability during and after the Cold War reveal a mix of structural, institutional, and compulsory power. Specifically, its renewal of the Non-Aligned Movement even after the end of bipolarity, its maintenance of autocracy amidst the pressures for democratization, and later support of radicalized Latin American leaders provide insight regarding unexpected sources of network power available to a resilient rogue state. [ABSTRACT FROM AUTHOR]

There is a constant need in forensic casework laboratories for an improved way to increase the first-pass success rate of forensic samples. The recent advances in mini STR analysis, SNP, and Alu marker systems have now made it possible to analyze highly compromised samples, yet few tools are available that can simultaneously provide an assessment of quantity, inhibition, and degradation in a sample prior to genotyping. Currently there are several different approaches used for fluorescence-based quantification assays which provide a measure of quantity and inhibition. However, a system which can also assess the extent of degradation in a forensic sample will be a useful tool for DNA analysts. Possessing this information prior to genotyping will allow an analyst to more informatively make downstream decisions for the successful typing of a forensic sample without unnecessarily consuming DNA extract. Real-time PCR provides a reliable method for determining the amount and quality of amplifiable DNA in a biological sample. Alu are Short Interspersed Elements (SINE), approximately 300bp insertions which are distributed throughout the human genome in large copy number. The use of an internal primer to amplify a segment of an Alu element allows for human specificity as well as high sensitivity when compared to a single copy target. The advantage of an Alu system is the presence of a large number (>1000) of fixed insertions in every human genome, which minimizes the individual specific variation possible when using a multi-copy target quantification system. This study utilizes two independent retrotransposon genomic targets to obtain quantification of an 80bp "short" DNA fragment and a 207bp "long" DNA fragment in a degraded DNA sample in the multiplex system InnoQuant™. The ratio of the two quantitation values provides a "Degradation Index", or a qualitative measure of a sample's extent of degradation. The Degradation Index was found to be predictive of the observed loss of STR markers and alleles as degradation increases. Use of a synthetic target as an internal positive control (IPC) provides an additional assessment for the presence of PCR inhibitors in the test sample. In conclusion, a DNA based qualitative/quantitative/inhibition assessment system that accurately predicts the status of a biological sample, will be a valuable tool for deciding which DNA test kit to utilize and how much target DNA to use, when processing compromised forensic samples for DNA testing., (Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.)

Caring for the 9 million low-income elderly or disabled adults who are eligible for full benefits under both Medicare and Medicaid can be extremely costly. As part of the federal Financial Alignment Initiative, states have the opportunity to test care models for dual-eligibles that integrate acute care, behavioral health and mental health services, and long-term services and supports, with the goals of enhancing access to services, improving care quality, containing costs, and reducing administrative barriers. One of the challenges in designing these demonstrations is choosing and applying measures that accurately track changes in quality over time—essential for the rapid identification of effective innovations. This brief reviews the quality measures chosen by eight demonstration states as of December 2013. The authors find that while some quality domains are well represented, others are not. Quality-of-life measures are notably lacking, as are informative, standardized measures of long-term services and supports.

Even during the Cold War, the United States and the Soviet Union cooperated on nuclear safety and security. Since accidental or unauthorized nuclear detonations anywhere threaten peace everywhere, it seems straightforward that states more experienced in developing nuclear safety and security technologies would transfer such methods to other states. Yet, the historical record is mixed. Why? While existing explanations focus on the political costs and proliferation risks faced by the transferring state, this article argues that specific technological features condition the feasibility of assistance. For more complex nuclear safety and security technologies, robust technical cooperation is crucial to build the necessary trust for scientists to transfer tacit knowledge without divulging sensitive information. Leveraging elite interviews and archival evidence, my theory is supported by four case studies: US sharing of basic nuclear safety and security technologies with the Soviet Union (1961–1963); US withholding of complex nuclear safety and security technologies from China (1990–1999) and Pakistan (1998–2003); and US sharing of complex nuclear safety and security technologies with Russia (1994–2007). My findings suggest the need to examine not only the motivations behind nuclear assistance but also the process by which it occurs and the features of the technologies involved, with implications for how states cooperate to manage the global risks of emerging technologies. [ABSTRACT FROM AUTHOR]

Objectives: Retrotransposable elements (REs), consisting of long interspersed nuclear elements (LINEs) and short interspersed nuclear elements (SINEs), are a group of markers that can be useful for human identity testing. Until now, however, due to the inherent size difference (up to 6 kb in some instances) associated with insertion and null alleles (or INNULs), the use of REs for facilitated population studies has not been sought or practical. The size of the insertion elements (from a few hundred to several thousand bp) has proven to limit their utility as a marker because of the inefficient amplicon yield with PCR. A novel primer design now facilitates INNUL marker testing. A preliminary panel of single-locus markers was developed to evaluate the potential of typing these insertion elements. Nine INNULs (5 Alu and 4 LINEs) were typed in three major North American populations and analyzed for population genetic features. In addition, the variation of each marker among the sample populations provides insight of its potential use as individual identification or ancestral marker., Methods: INNUL markers were developed into fluorescently labeled single-loci PCR. Nine markers were developed with amplicons that were less than 180 bp in length, and, depending on the locus amplicons of the INNULs, alleles varied in size from 50 to 1 bp. This allele size is noteworthy because the insertion alleles of the 9 loci range in size from 297 to 6,195 bp. The allele distribution of the INNULs was assessed and analyzed in three major North American populations., Results: Upon observation of the distribution of the alleles in three major North American populations, the markers generally met Hardy-Weinberg expectations, and there was little evidence of detectable levels of linkage disequilibrium. Due to varying distributions of the alleles in the major population groups tested, some of the markers might be better suited for use as an individual identification marker, while others are better suited for bio-ancestral studies., Conclusions: Using the primer design strategy described in our work, SINEs and (for the first time, to our knowledge) LINEs can be utilized as markers for studying population genetic variation that is more amenable to the limitations of the PCR technique. This study lays the foundation for future work of developing a multiplex panel of INNUL markers that can be used as a single-tube assay for human identity testing utilizing small amplicons (<180 bp), which could be useful for ancient or degraded forensic DNA samples., (Copyright © 2012 S. Karger AG, Basel.)

Background: Many instances of coordination problems in social networks can be characterized by the well-known graph coloring game—a task in which agents are incentivized to choose an attribute, represented by a color, to be different from linked neighbors. Past work on this topic, however, is limited to static networks of specific topologies of interest. Purpose: This study aims to explore whether dynamic networks, where players can choose their partners, perform better in the graph coloring game. Research Design: We replicate the conventional graph coloring game experiment and introduce a new version where players can change their network neighbors. Study Sample and Data Collection: We recruited over 300 human participants for the experiment, with each session involving an average of 20 participants per network. Results: We found that dynamic networks that allow agents to switch network neighbors works more effectively and efficiently in solving coloring conflicts than static networks in which people are allowed to change color alone. The networks in the experiment updated by people's selection of neighbors tend to evolve to a state similar in structure to the small-world network characterized by short path distance and high triadic clustering. Conclusion: We argue that a self-organized approach demonstrated by our experiment can inspire search of behavioral strategies and network topologies for solving coordination problems in social networks. [ABSTRACT FROM AUTHOR]

In this research article, we provide empirical evidence for the hypothesis that there are substantial elite-public gaps in attitudes toward the military use of nuclear and chemical weapons. We designed and preregistered an original survey investigating support for nuclear and chemical strikes in a hypothetical scenario and fielded it to representative samples of British citizens and parliamentarians. Our results provide strong empirical support for the elite-public gap hypothesis, with the parliamentarians expressing a significantly stronger aversion to nuclear and chemical use than the public respondents. These findings contribute to contemporary scholarly debates on the nature and strength of nuclear and chemical weapon "taboos" in world politics. [ABSTRACT FROM AUTHOR]

Preferential trade agreements (PTAs) are generally understood to promote political cooperation between members. I argue that institutional exclusion can damage political cooperation between members and non-members. Preferential trade agreements reflect strategic considerations, enabling countries to promote new trade norms, strengthen diplomatic networks, and redirect commercial flows to allies. Excluded countries are denied these benefits and may possibly be targeted by members. Thus, excluding PTAs may be perceived as threats. The record of the Trans-Pacific Partnership illustrates the theory. Statistical analysis of the near-universe of PTAs and countries' voting affinities in the United Nations General Assembly supports the argument. [ABSTRACT FROM AUTHOR]

Purpose To compare the clinical characteristics, surgical management and prognosis of mesenteric lymphatic malformations (ML) and omental lymphatic malformations (OL) in children. Methods This retrospective study included 148 ML patients and 53 OL patients who underwent surgical treatment at two centers between January 2016 and December 2022. Details about the patients’ clinical characteristics, cyst characteristics, preoperative complications, surgical methods, and prognosis were retrieved and compared. Results No significant differences in sex ratio, prenatal diagnosis, or age of diagnosis were noted between ML and OL patients. Vomiting was more common in ML patients than in OL patients (46.6% vs. 22.6%, P=0.002), but OL patients were more likely to be misdiagnosed (35.8% vs. 18.9%, P=0.012). The size of the cysts in OL patients was significantly larger than that in ML patients (14.0 [4.0–30.0] vs. 10.0 [2.0–50.0] cm, P<0.001), and cysts with turbid fluid were more common in OL patients (38.0% vs. 20.6%, P<0.001). More OL patients than ML patients had preoperative hemorrhage or infection of cysts (41.5% vs. 31.8%, P<0.016). Cyst excision was performed in 137 (92.6%) ML patients and 51 (96.2%) OL patients, and the incidence of postoperative complications was lower (12.6% vs. 4.2%, P=0.165) among OL patients. The main postoperative complications included adhesive ileus and recurrence of cysts. Additionally, more OL patients than ML patients were treated with laparoscopic surgery (69.8% vs. 39.2%, P<0.001). Conclusions There were differences in clinical characteristics, cyst characteristics and preoperative complications between ML and OL patients. Cyst excision was the most common surgical method that was used to treat both ML and OL patients, and laparoscopic surgery could be a feasible surgical approach for treating OL patients with a good prognosis. [ABSTRACT FROM AUTHOR]

International institutions strive to achieve their own objectives while operating within a complex network of interdependencies. These interdependencies create an extensive web of relationships that serve as potential pathways for broader institutional impacts. The actions taken by individual institutions, their mutual influences, and the pattern of connectivity collectively shape the overall performance of institutional complexes. Understanding the performance of these complexes is crucial, yet we currently lack a methodology to assess it. To address this gap, we have developed a conceptual framework that integrates three distinct areas of study on three different scales: institutional effectiveness, institutional interlinkages, and institutional networks. This framework enables us to consider what we call the latent net effectiveness, or collective problem-solving potential, of a group of interconnected institutions. To put this framework into practice, we have devised a heuristic model, drawing from the extensive literature on international environmental institutions. As an illustrative example, we have applied this model to a network of 378 multilateral environmental agreements with 810 known issue linkages. Our work underscores the relevance of considering the system-level properties of institutional complexes and emphasizes the need for timely network-based governance and policy interventions to enhance the overall effectiveness of institutional complexes. This article is part of the theme issue 'A complexity science approach to law and governance'. [ABSTRACT FROM AUTHOR]

Objectives: Despite renewed research interest in prison social organization, little is known about how relationships that constitute the prison social system develop and change. The current study aims to understand the processes that link friendship and power within a prison unit over time. Method: We examine longitudinal data on friendship and attributions of power collected from 274 residents in a Pennsylvania medium-security prison unit. We use a stochastic actor-oriented model to evaluate selection mechanisms that influence these relations and ascertain their temporal association. Results: We find different mechanisms responsible for friendship selections and power attributions. Friendships are primarily driven by attribute-based mechanisms, while power attributions are driven by network-based properties. Nevertheless, these two facets of social structure are interdependent, with friendships operating as building blocks for the development of power hierarchy in prison. Conclusion: By conceptualizing social structure as a multidimensional, fluid entity, we identify the unique roles that power and friendship relations play in recreating the prison social system. We maintain that understanding social structure in prison settings can provide insight into institutional adjustments and post-release expectations. [ABSTRACT FROM AUTHOR]

States often use reservations to modify their treaty obligations. Prior research demonstrates why states enter reservations and why states object to reservations, but little work explains why states withdraw them. We argue that states withdraw reservations in response to international social pressure. Using novel data on reservations and reservation withdrawals for the nine core international human rights treaties, our analyses reveal two factors that compel states to withdraw reservations: (1) pressure from peer states and (2) pressure from human rights treaty bodies conducting periodic reviews. While previous work emphasizes domestic factors, our research shows that the international community encourages states to withdraw reservations and strengthen their commitments to human rights and international law. [ABSTRACT FROM AUTHOR]

This paper examines the relationship between ideological polarization and party disloyalty, focusing on the moderating role of the status of a political party in the legislature, i.e., the ruling party or the opposition party. It hypothesizes that the ruling party is willing to endorse disloyal candidates whose issue positions are not close to their own party's platform, whereas the opposition party is likely to punish disloyal candidates to demonstrate party unity in the nomination process. The present study tests this hypothesis, using data from South Korea, where the nomination process for the parliamentary election is dominated by party leaders. The results are by and large consistent with the hypotheses. In line with previous studies, our results suggest that party loyalty is one of the driving forces of polarization in politics. In order to fully understand party polarization at the level of political elites, it is necessary to consider heterogeneous effects of party members' behavior on candidate selection, varying across the party's status, either the ruling party or the opposition party. [ABSTRACT FROM AUTHOR]

How does the increasingly dense network of overlapping institutions in global governance affect the design of intergovernmental organizations (IGOs)? We argue that institutional overlap can unleash mimicking dynamics whereby states design new IGOs using the design of existing organizations that engage in similar issue areas and perform similar governance tasks for similar member states as templates. Using design templates from the reference group of overlapping institutions is a strategy for boundedly rational designers in situations of complexity because it reduces uncertainty and lowers the costs of identifying suitable institutional solutions. Overlap therefore increases the design similarity between new and pre-existing IGOs, specifically where pre-existing organizations have institutional designs that made them endure. Introducing a new measure of institutional overlap in global governance and new data on the design and governance tasks of the 534 IGOs from the Correlates of War Project, we corroborate our argument using regression analyses. Our results hold important lessons for theories of institutional design, regime complexity, and global governance more broadly. [ABSTRACT FROM AUTHOR]

Despite growing scholarly interest in international rankings, we know little on how the public perceives them. Do rankings bring citizens to favor compliance with international standards? Or do citizens simply dismiss the rankings? We examine these questions through the Israeli public's response to the U.S. tier ranking of efforts against human trafficking. A survey experiment finds that Israel's demotion from Tier 1 to Tier 2 leaves Israelis unfazed; a demotion to Tier 3 produces a surprising backlash effect, reducing Israelis' support for anti-trafficking efforts. While this should have been a likely case for demonstrating the intended impact of rankings, we show that rankings might, in fact, meet a dismissive or defiant public response. This finding suggests caution in the assessment of international rankings' domestic impact, and it carries implications for the design of rankings to reduce the risk of a backlash. [ABSTRACT FROM AUTHOR]

In the last 40 years, the international community has made considerable progress towards the regulation of inhumane conventional weapons (ICWs) by adopting treaties that regulate or ban these weapons. However, many states have still not joined these treaties or have joined them with a considerable delay. These ratification decisions cannot be satisfactorily explained by the existing literature on the origin of ICW treaties, which stress the role of global socialization processes. This article offers a theoretical argument that explains state decisions on the ratification of ICW treaties. It argues that while democracies and countries located in regions with high ratification rates are prone to ratify ICW treaties, an insecure external environment impedes or delays ratification. The argument also claims that security costs resulting from the characteristics of the individual treaties can modify the effects of these explanatory factors. To provide an empirical test for the argument, the article conducts a survival analysis that covers the ratification processes of the three existing ICW treaties. [ABSTRACT FROM AUTHOR]

Purpose: The purpose of this study is to evaluate the association between hyperparathyroidism (PHPT), parathyroid hormone levels, and calcium levels in patients diagnosed with benign fibro-osseous lesions such as fibrous dysplasia (FD), ossifying fibroma (OF), central giant cell granulomas (GCG)., Methods: This is a retrospective, single-center study from a sample of patients who underwent surgical treatment of FD, OF, and GCG at Mayo Clinic between 1996 and 2021. Patient demographics, history of PHPT, histopathological diagnosis, and relevant laboratory values such as parathyroid hormone (PTH), serum calcium, vitamin D, and alkaline phosphatase were collected., Results: Of the patients diagnosed with FD (n = 64), OF (n = 24), and GCG (n = 5), a diagnosis of PHPT was found in 2 patients (3.1%), 1 patient (4.2%), and 0 patients (0%), respectively. Elevated PTH levels (>65 pg/mL) were observed in 3 patients (4.7%) with FD, 1 patient (4.2%) with OF, and 1 patient (20%) with GCG. Mean (standard deviation) calcium levels were 9.3 (0.6) mg/dL in the FD group, 9.4 (0.5) mg/dL in the OF group, and 9.3 (0.6) mg/dL in the GCG group. Patients with fibro-osseous jaw tumors including FD, OF, and GCG may have increased risk of PHPT compared to the general population., Conclusion: Patients with benign jaw tumors including FD, OF, and GCG may have increased risk of PHPT compared to the general population. Surgeons treating these benign tumors need to be cognizant of these findings, obtain appropriate laboratory studies, and incorporate multidisciplinary care including endocrinologists, endocrine surgeons, and maxillofacial surgeons., (© 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.)

International trade research plays an important role to inform trade policy and shed light on wider economic issues. With recent advances in information technology, economic agencies distribute an enormous amount of internationally comparable trading data, providing a gold mine for empirical analysis of international trade. International trading data can be viewed as a dynamic transport network because it emphasizes the amount of goods moving across network edges. Most literature on dynamic network analysis concentrates on parametric modeling of the connectivity network that focuses on link formation or deformation rather than the transport moving across the network. We take a different non-parametric perspective from the pervasive node-and-edge-level modeling: the dynamic transport network is modeled as a time series of relational matrices; variants of the matrix factor model of Wang et al. (2019) are applied to provide a specific interpretation for the dynamic transport network. Under the model, the observed surface network is assumed to be driven by a latent dynamic transport network with lower dimensions. Our method is able to unveil the latent dynamic structure and achieves the goal of dimension reduction. We applied the proposed method to a dataset of monthly trading volumes among 24 countries (and regions) from 1982 to 2015. Our findings shed light on trading hubs, centrality, trends, and patterns of international trade and show matching change points to trading policies. The dataset also provides a fertile ground for future research on international trade. [ABSTRACT FROM AUTHOR]

Research into parliamentary speech making–behaviour of Members of the European Parliament (MEPs) usually takes a static perspective. We offer an interactive and dynamic approach that understands parliamentary debates as a relational network phenomenon and investigates MEPs' debate interactions. This allows us to uncover dynamics of inclusiveness and pluralism, self-reinforcing power relationships and transnational policy alliances. Analyzing 11,408 debate interactions between MEPs using a combination of text and dynamic network analysis, we find that male, senior and influential parliamentarians from powerful member states receive more attention with evidence for a self-reinforcing effect over time. Interestingly, seniority matters more for debate attention than leadership positions. Sharing the same nationality and a similar political leaning also shape debate coalitions with the former being more important than the latter. [ABSTRACT FROM AUTHOR]

Limited space to engage in advocacy is one manifestation of a restrictive civic environment. In environments where civil society organizations (CSOs) are keen to maintain a low profile, non-confrontational advocacy mechanisms are often preferred. Based on a case study on the adoption of an Egyptian law that criminalizes denial of inheritance to women, this paper investigates how CSOs engage in advocacy in restrictive settings. The aforementioned law was put forth by a coalition of CSOs in Egypt and led by an international NGO. Using an original analytical framework, I argue that the coalition's ability to navigate the restrictive environment in Egypt can be explained by a confluence of factors, including that the issue did not conflict with beliefs of powerful decision-makers, that the CSOs were perceived as legitimate and had good network reach, and that the CSOs used insider tactics and non-controversial framing to mobilize support of influential government actors. [ABSTRACT FROM AUTHOR]

The arms trade has come to the center stage of the international political economy. Yet only a few quantitative studies have been conducted on the political economy of the arms trade. This paper focuses on the security rents shared by trading partners in determining their arms trade relationship. We argue that the mechanism of reciprocity is better understood from the perspective of an international alliance network. Because the rents are likely to be transferred to other related members in a community, when a state is engaged in an arms deal with another state, it takes into account not only the direct dyadic relationship but also the alliance community to which the other state belongs. Based on this understanding, we employ social network analysis (SNA) to identify the effect of the international alliance community on the arms trade. Our findings suggest that if two states have a tie in a political alliance network, they are also likely to have a tie in the arms sale network. Moreover, we also find that the alliance network is a strong predictor of bilateral arms sales. Being in the same alliance community encourages two states to trade more arms with each other. [ABSTRACT FROM AUTHOR]

This article situates recent initiatives to deepen security and defence cooperation in the European Union in the historical perspective. It proposes a model of constitutive relationship between the process of change in a security community and the formation of a transnational defence industry community of practice which yields positive feedback ('productive returns') to the security community as a broader assemblage within which it was constituted. This model is applied to the paradigmatic case of European security community that formed after the World War II (WWII). The analysis shows that the key driver for defence integration traced by means of social network analysis (SNA) in this case was economic rather than political, and for an extended period of time it developed without formal institutions. The productive return of the 'defence industry machine' as a distinct community of practice that was constituted through the integration process consisted in the sense of deeper belonging and a shared sense of working well together in a traditionally highly nationalised defence milieu. [ABSTRACT FROM AUTHOR]

Forensic DNA analysis continues to be hampered by the complex interactions between metals and DNA. Metal ions may cause direct DNA damage, inhibit DNA extraction and polymerase chain reaction (PCR) amplification or both. This study evaluated the impact of metal ions on DNA extraction, quantitation, and short tandem repeat profiling using cell-free and cellular (saliva) DNA. Of the 11 metals assessed, brass exhibited the strongest PCR inhibitory effects, for both custom and Quantifiler Trio quantitation assays. Metal ion inhibition varied across the two quantitative PCR assays and the amount of DNA template used. The Quantifiler Trio internal PCR control (IPC) only revealed evidence of PCR inhibition at higher metal ion concentrations, limiting the applicability of IPC as an indicator of the presence of metal inhibitor in a sample. Notably, ferrous ions were found to significantly decrease the extraction efficiency of the DNA-IQ DNA extraction system. The amount of DNA degradation and inhibition in saliva samples caused by metal ions increased with a dilution of the sample, suggesting that the saliva matrix provides protection from metal ion effects., (© 2023 The Authors. Electrophoresis published by Wiley‐VCH GmbH.)

Sanctions are among the most widely used foreign policy tools of governments and international organizations in response to national or international wrongdoings. Beyond the dichotomous question of whether to adopt or not to adopt sanctions against a target, decision-makers develop different designs when they impose restrictions: targeted sanctions like asset freezes and travel bans, arms embargoes, or economic sanctions such as financial restrictions and commodity bans. What accounts for this variation in the design of sanctions regimes? This article investigates this question by developing a configurational explanation that combines domestic- and international-level factors for the choice of an economic versus a targeted sanctions design. I test these factors on original data mapping European Union (EU) autonomous sanctions against third countries in force in 2019 through set-theoretic methods. The analysis shows that a militarily strong target's serious misbehavior through grave human rights violations triggers EU action in the form of economic sanctions, however, only in combination with two conditions: first, the EU reacts to a misbehavior through the adoption of an economic design when the United States imposes economic sanctions, too (path 1); second, the salience of a target's conflict triggers an economic design of sanctions in case of grave human rights violations (path 2). [ABSTRACT FROM AUTHOR]

Nongovernmental organizations (NGOs) have actively participated in the policymaking process within international organizations (IOs) by providing policy information. But due to limited policy attention and agenda space, IOs are capable of accommodating some but not all NGO information. How do IOs decide which NGO information to be accepted on the international agenda? Leveraging a unique information-filtering mechanism in the Office of the United Nations High Commissioner for Human Rights' (OHCHR) preparation of summary reports that selectively incorporate information from NGO shadow reports during the United Nations Universal Periodic Review between 2008 and 2016, this article looks inside the "black box" of agenda setting in global governance. Using an original corpus of documents from OHCHR and more than 7000 advocacy organizations or coalitions, and a new method that quantifies OHCHR's information gatekeeping behavior, I provide empirical support for the general claim that IOs are more likely to adopt NGO information provided by more reputable informants, expressed in neutral language, and supported by a greater number of organizations. These findings highlight the importance of IO agency in shaping the transnational advocacy agenda. [ABSTRACT FROM AUTHOR]

We present findings of a survey experiment on a sample of 2350 American and British citizens, in which we examined attitudes towards nuclear and chemical strikes. Our findings demonstrate that even though the public accurately judges nuclear weapons as more destructive and indiscriminate, it is still more averse to the use of chemical than nuclear weapons. Our follow up study has shown that individuals are significantly more likely to associate chemical weapons with "rogue states" and terrorists, and associate nuclear weapons with modern powers. The findings contribute to scholarship on the "taboos" surrounding the (non-)use of WMDs in world politics. [ABSTRACT FROM AUTHOR]

This work demonstrates the expanding methodological approaches to the study of transnational policy transfer and combines the quantitative methods of SNA and the generation of sociograms with qualitative processes of iterative validation with key informants. The work maps and then critiques the differences in domestic policy networks and transfer policy networks. Transfer networks are distinct from domestic operational networks, yet each is interrelated and retains shared interests. Diagnosing and plotting the structure, density and complexity of actor relations in one domestic policy network provides insight into the challenges that another jurisdiction may face to effectively adopt and implement a similar policy once it progresses through transfer. An important contribution of this work is how SNA more explicitly highlights the connection of transnational policy transfer structures to key nodes in domestic networks and the dual role these actors play in the very differently configured domestic (operational) and transfer networks. In this case, we see how transnational policy transfer is both strengthened and constrained by its network relations with domestic policy systems. While actors effectively interact in the exchange of information and share ideas to support policy transfer, network analysis would also suggest a distinctly different network of actors is required to achieve effective adoption and local implementation. [ABSTRACT FROM AUTHOR]

Ossifying fibroma in the fronto-ethmoidal sinuses is a rare, benign condition. In symptomatic cases, surgical excision is often undertaken and bony defects may be repaired using alloplastic grafts. We present a novel method of repairing an orbital roof defect using irradiated homologous cadaveric rib (Tutoplast ®) graft, overlaid with a pericranial flap. The patient made an excellent recovery, concluding that it is a viable and safe option with lower morbidity. [ABSTRACT FROM AUTHOR]

There is a relationship between the trade flows of the countries and their economic growth potential and development. One way to analyze the trade flows of countries with each other is the use of network analysis techniques. Network analysis uses a visual, mathematical and statistical approach to identify and quantify the structural properties of networks. In this study, the relationship of the first 50 countries in the world in terms of export volume was evaluated with Gephi 0.9.2, one of the social network analysis programs. The effect of the COVID-19 epidemic disease on the commercial flows of the countries is the main purpose of the study. The existence of the effective role of geographic proximity in commercial flows, the commercial partners of the countries, the centrality criteria and the existence of countries that have an active role in the world are clarified with this study. [ABSTRACT FROM AUTHOR]