31 results on '"Metabolic Syndrome veterinary"'
Search Results
2. Emerging Human Medications in Racing Animals: Analytical and Regulatory Challenges.
- Author
-
Dorakumbura BN, Beckett NM, Cook EC, Nolan AD, Brown D, and Douglas B
- Abstract
Positive identification and reporting of therapeutic substances intended for human consumption in race-day equine and canine samples is a controversial topic. While inadvertent environmental exposure is a potential cause for the presence of these substances in race-day samples, intentional use cannot be ruled out given their therapeutic benefits. Pregabalin is widely prescribed in Australia to treat epilepsy, anxiety, and neuropathic pain in humans; however, it is also increasingly used as a recreational drug. Metformin is commonly used to treat type 2 diabetes in humans. Both pregabalin and metformin have no routine use on racing animals and should not be present in race-day samples taken from healthy animals. They are prohibited substances under the Rules of Racing with no established screening limits. Although therapeutic levels for these substances have been established in humans, such information is not available for animals. Pregabalin and metformin are analytically challenging molecules, more so when they are extracted from biological matrices routinely screened for hundreds of other compounds simultaneously. A simple extraction, followed by a targeted Ultra High-Pressure Liquid Chromatography Orbitrap™ Mass Spectrometry method utilising a reverse-phase C18 column, is presented. This method is effective in screening for pregabalin and metformin, in addition to more than 150 other compounds of interest in equine and canine urines. The prevalence of pregabalin and metformin in race-day equine and canine urine samples in Western Australia was monitored using this method over 12 months. More than 4000 urine samples were screened, and four samples were confirmed positive for these substances., (© 2024 John Wiley & Sons Ltd.)
- Published
- 2024
- Full Text
- View/download PDF
3. Sex hormone-binding globulin improves lipid metabolism and reduces inflammation in subcutaneous adipose tissue of metabolic syndrome-affected horses.
- Author
-
Bourebaba, Lynda, Kępska, Martyna, Qasem, Badr, Zyzak, Magdalena, Łyczko, Jacek, Klemens, Marta, Mularczyk, Malwina, and Marycz, Krzysztof
- Published
- 2023
- Full Text
- View/download PDF
4. The PTP1B Inhibitor Trodusquemine (MSI-1436) Improves Glucose Uptake in Equine Metabolic Syndrome Affected Liver through Anti-Inflammatory and Antifibrotic Activity.
- Author
-
Bourebaba, Lynda, Serwotka-Suszczak, Anna, Bourebaba, Nabila, Zyzak, Magdalena, and Marycz, Krzysztof
- Subjects
GLUCOSE metabolism ,FLOW cytometry ,CYTOKINES ,HOMEOSTASIS ,HYPERGLYCEMIA ,ENDOCRINE diseases ,ANTI-inflammatory agents ,ANIMAL experimentation ,FIBROSIS ,PROTEIN-tyrosine kinase inhibitors ,AMINES ,LIVER diseases ,GENE expression ,METABOLIC syndrome ,PLANT extracts ,MICE ,INSULIN resistance ,PHENOTYPES ,PHARMACODYNAMICS - Abstract
Background. Hyperactivation of protein tyrosine phosphatase (PTP1B) has been associated with several metabolic malfunctions ranging from insulin resistance, metaflammation, lipotoxicity, and hyperglycaemia. Liver metabolism failure has been proposed as a core element in underlying endocrine disorders through persistent inflammation and highly fibrotic phenotype. Methods. In this study, the outcomes of PTP1B inhibition using trodusquemine (MSI-1436) on key equine metabolic syndrome (EMS)-related alterations including inflammation, fibrosis, and glucose uptake have been analyzed in liver explants collected from EMS-affected horses using various analytical techniques, namely, flow cytometry, RT-qPCR, and Western blot. Results. PTP1B inhibition using trodusquemine resulted in decreased proinflammatory cytokines (IL-1β, TNF-α, and IL-6) release from liver and PBMC affected by EMS and regulated expression of major proinflammatory microRNAs such as miR-802 and miR-211. Moreover, MSI-1436 enhanced the anti-inflammatory profile of livers by elevating the expression of IL-10 and IL-4 and activating CD4
+ CD25+ Foxp3+ regulatory T cells in treated PBMC. Similarly, the inhibitor attenuated fibrogenic pathways in the liver by downregulating TGF-β/NOX1/4 axis and associated MMP-2/9 overactivation. Interestingly, PTP1B inhibition ameliorated the expression of TIMP-1 and Smad7, both important antifibrotic mediators. Furthermore, application of MSI-1436 was found to augment the abundance of glycosylated Glut-2, which subsequently expanded the glucose absorption in the EMS liver, probably due to an enhanced Glut-2 stability and half-life onto the plasma cell membranes. Conclusion. Taken together, the presented data suggest that the PTP1B inhibition strategy and the use of its specific inhibitor MSI-1436 represents a promising option for the improvement of liver tissue integrity and homeostasis in the course of EMS and adds more insights for ongoing clinical trials for human MetS management. [ABSTRACT FROM AUTHOR]- Published
- 2023
- Full Text
- View/download PDF
5. Sex hormone-binding globulin (SHBG) mitigates ER stress and improves viability and insulin sensitivity in adipose-derived mesenchymal stem cells (ASC) of equine metabolic syndrome (EMS)-affected horses.
- Author
-
Bourebaba, Nabila, Sikora, Mateusz, Qasem, Badr, Bourebaba, Lynda, and Marycz, Krzysztof
- Subjects
INSULIN sensitivity ,MESENCHYMAL stem cells ,METABOLIC syndrome ,GLOBULINS ,MOLECULAR chaperones ,INSULIN receptors ,HORSE breeds - Abstract
Background: Equine metabolic syndrome (EMS), which encompasses insulin resistance, low-grade inflammation and predisposition to laminitis is a critical endocrine disorder among the most prevalent conditions affecting horses from different breeds. According to the most recent research, low human sex hormone-binding globulin (SHBG) serum levels correlate with an increased risk of obesity, insulin resistance and diabetes, and may contribute to overall metabolic dysregulations. This study aimed to test whether exogenous SHBG could protect EMS affected adipose-derived stromal stem cells (EqASC
EMS ) from apoptosis, oxidative stress, ER stress and thus improve insulin sensitivity. Methods: EqASCEMS wells were treated with two different concentrations (50 and 100 nM) of exogenous SHBG, whose biocompatibility was tested after 24, 48 and 72 h of incubation. Several parameters including cell viability, apoptosis, cell cycle, reactive oxygen species levels, ER stress, Pi3K/MAPK activation and insulin transducers expression were analysed. Results: Obtained data demonstrated that exogenous SHBG treatment significantly promoted ASCs cells proliferation, cell cycle and survival with reduced expression of p53 and p21 pro-apoptotic mediators. Furthermore, SHBG alleviated the oxidative stress caused by EMS and reduced the overaccumulation of intracellular ROS, by reducing ROS + cell percentage and regulating gene expression of endogenous antioxidant enzymes (Sod 1, Cat, GPx), SHBG treatment exhibited antioxidant activity by modulating total nitric oxide (NO) levels in EMS cells as well. SHBG treatment dampened the activation of ER stress sensors and effectors in EqASCEMS cells via the upregulation of MiR-7a-5p, the decrease in the expression levels of ATF-6, CHOP and eiF2A and the restoration of PDIA3 chaperone protein levels. As a consequence, SHBG application substantially improved insulin sensitivity through the modulation of Pi3K/Akt/Glut4 insulin signalling cascades. Conclusion: Our results suggest that the SHBG is endowed with crucial beneficial effects on ASCs metabolic activities and could serve as a valuable therapeutic target for the development of efficient EMS treatment protocols. 1CMnBWH6nCsmkUsG-EU1vw Video Abstract [ABSTRACT FROM AUTHOR]- Published
- 2023
- Full Text
- View/download PDF
6. Effect of pony morphology and hay feeding methods on back and neck postures.
- Author
-
Bordin C, Raspa F, Harris P, Ellis AD, Roggero A, Palestrini C, Bergero D, and Valle E
- Subjects
- Animals, Horses physiology, Horses anatomy & histology, Animal Husbandry methods, Back anatomy & histology, Diet veterinary, Male, Animal Feed analysis, Posture, Neck anatomy & histology
- Abstract
The application of hay feeding devices, such as the use of hay nets or slow feeders, can help with the management of weight in ponies; however, there is still a lack of knowledge regarding their effect on equine posture. Therefore, the aim of the study was to assess the effect of different feeding devices on the posture of ponies using morphometric analysis. Two different breed types, Shetland type (SH, n = 5) versus Welsh Cob type (WC, n = 4), were fed the same forage in four different ways: on the ground (G), using a fully filled haynet (HF), using a partially filled haynet (HL) and using a slow-feeder hay box (HB). Video recordings were obtained and then geometric morphometric analysis was applied. Breed morphology was confirmed by body morphometric measurements. Data were analysed statistically using one-way ANOVA, canonical variate analysis (CVA), principal component analysis (PCA), partial least-squares (PLS) analysis and multivariate analysis of variance (MANOVA). Moreover, a mixed model was performed to study differences in mandibular angle. SH and WC ponies were shown to have significantly different body morphometric measurements. The geometric morphometric analysis results showed that ponies arch their back and modify their neck shape differently according to the feeding method and their morphological group. For the neck, the SH and WC ponies adapted similarly to the use of small-holed hay nets, but their posture varied when feeding from the ground or hay box. The back postures consistently differed according to the breed type and feeding method. The mandibular angle for both breed types was reduced with all the feeding devices compared to feeding from the ground. Further studies are needed to evaluate the long-term effects of slow-feeding devices on posture and mandibular angle, taking into consideration animals with different morphologies., (© 2023 MARS Horsecare and The Authors. Journal of Animal Physiology and Animal Nutrition published by Wiley‐VCH GmbH.)
- Published
- 2024
- Full Text
- View/download PDF
7. A study on obesity and risk factors among leisure and polo horses in Kaduna State, Nigeria.
- Author
-
Akinniyi, Olumide Odunayo, Sackey, Anthony Kojo Beku, Ochube, Gabriel Enenche, and Mshelia, Philip Wayuta
- Subjects
HORSES ,HORSE breeds ,HORSE health ,LOGISTIC regression analysis ,HORSE breeding - Abstract
Despite the growing concern about the impact of obesity on equine health, little information is available on equine obesity in Nigeria. The study aimed to determine the prevalence of obesity in leisure and polo horses as well as associated risk factors in Kaduna State, Nigeria. A cross-sectional study was carried out. A total of 116 horses were selected for the study, and the modified Henneke method (1-9 scale) was used to assess body condition scores, with animals having a score of ≥ 7 classified as obese. Information regarding age, breed, and sex was documented, while information regarding feeding and management was obtained from a structured questionnaire. Factors associated with obesity were assessed using logistic regression analysis. The overall prevalence of obesity in horses sampled was 12.1 % (14/116). The prevalence of obesity in leisure horses (21.4 %) was higher than in polo horses (3.3 %). Factors associated with increased odds of obesity were being a local breed of horse (18.6 %), being a stallion (21.4 %), horses not being exercised (66.7 %), horses tethered to a stake in the ground (23.2 %), and horses fed ad libitum on concentrates (21.4 %). Knowing the prevalence of obesity in this population and associated risk factors will enable optimal targeting of owner education regarding management strategies to reduce the prevalence of equine obesity, reducing the risk of conditions such as laminitis and insulin dysregulation. [ABSTRACT FROM AUTHOR]
- Published
- 2023
- Full Text
- View/download PDF
8. Comparison of Hematological and Biochemical Profiles of Late Pregnant and Non-Pregnant Thoroughbred Mares.
- Author
-
Onur Yazlik, Murat, Dikmeoglu, Ezgi, Esen, Arzu, Kaya, Ufuk, Kafkas, Özgenur, Baran, Burak, and Göcen, Murat
- Subjects
THOROUGHBRED horse ,FETAL development ,HEMATOLOGY ,BLOOD cell count ,BILIRUBIN ,ALBUMINS - Abstract
Copyright of Jurnal Veteriner is the property of Fakultas Kedokteran Hewan, Universitas Udayana and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2021
- Full Text
- View/download PDF
9. Glucose concentration during equine in vitro maturation alters mitochondrial function.
- Author
-
Lewis, Niamh, Hinrichs, Katrin, Leese, Henry J., Argo, Caroline McGregor, Brison, Daniel R., and Sturmey, Roger G.
- Subjects
LACTATES ,GLUCOSE ,MAMMALIAN embryos ,ENERGY metabolism ,GENE expression - Abstract
The use of in vitro embryo production in the horse is increasing in clinical and research settings; however, protocols are yet to be optimised. Notably, the two most commonly used base media for in vitro maturation (IVM) supply glucose at markedly different concentrations: physiological (5.6 mM, M199) or supraphysiological (17 mM, DMEM/F-12). Exposure to high glucose has detrimental effects on oocytes and early embryos in many mammalian species, but the impact has not yet been examined in the horse. To address this, we compared the energy metabolism of equine COCs matured in M199-based maturation medium containing either 5.6 or 17 mM glucose, as well as expression of key genes in oocytes and cumulus cells. Oocytes were fertilised by ICSI and cultured. Analysis of spent medium revealed that COC glucose consumption and production of lactate and pyruvate were similar between treatments. However, the glycolytic index was decreased at 17 mM and analysis of mitochondrial function of COCs revealed that IVM in 17 mM glucose was associated with decreased ATP-coupled respiration and increased non-mitochondrial respiration compared to that for 5.6 mM glucose. We also found that the metabolic enzyme lactate dehydrogenase-A (LDHA) was downregulated in cumulus cells of oocytes that completed IVM in 17 mM glucose. There was no difference in maturation or blastocyst rates. These data indicate that COC mitochondrial function and gene expression are altered by high glucose concentration during IVM. Further work is needed to determine if these changes are associated with developmental changes in the resulting offspring. [ABSTRACT FROM AUTHOR]
- Published
- 2020
- Full Text
- View/download PDF
10. Efficacy of Wu Mei Wan for Treating Equine Metabolic Syndrome Related Laminitis and Uveitis Poorly Responsive to Conventional Medicine.
- Author
-
Lankenau, Cynthia J.
- Subjects
EQUINE metabolic syndrome ,LAMINITIS ,UVEITIS ,HERBAL medicine ,CHINESE medicine ,HORSES - Abstract
A classical Chinese herbal medicine, Wu Mei Wan, was used to treat horses affected with equine metabolic syndrome (EMS) with concurrent laminitis and/or uveitis associated with a pattern in Chinese medicine known as Jue Yin syndrome. Twentyfour EMS patients with concurrent laminitis (16/24) or uveitis (4/24) or both presentations (4/24) that were poorly responsive or unresponsive to conventional treatments were enrolled. All horses were orally medicated with Wu Mei Wan for 30 days. Horses with laminitis, received baseline scores (0-5) before treatment followed by weekly scores until study termination. Horses with uveitis were assessed by the degree of eye opening at the same time points (0 fully open to 4 tightly shut). Successful treatment outcome for either condition, was at least 50% improvement (with respect to the clinical assessment score) by the end of the 4-week study. All 20 horses with laminitis had improved lameness scores after 1 week of treatment (mean score 3.85 ±0.88 reduced to 1.2 ±1.11) with percent mean reduction among subjects of 69.8%, 81.2%, 93.8% and 97.1% after 1, 2, 3, and 4 weeks of treatment, respectively. All 8 uveitis subjects had improved scores after 1 week (mean score 3.25 ±0.89 reduced to 0.625 ±0.74) and mean reduction of 80.2%, 86.5% after 1 and 2 weeks of treatment, respectively. The response rate for both laminitis and uveitis was 100% (50% improvement, week 4) with all p-values < 0.001. Study results suggest that the Chinese herbal medicine, Wu Mei Wan, may be an effective treatment for unresponsive cases of laminitis and/ or uveitis associated Jue Yin and equine metabolic syndromes. [ABSTRACT FROM AUTHOR]
- Published
- 2019
11. 5-Azacytidine and Resveratrol Enhance Chondrogenic Differentiation of Metabolic Syndrome-Derived Mesenchymal Stem Cells by Modulating Autophagy.
- Author
-
Marycz, K., Houston, J. M. Irwin, Weiss, C., Röcken, M., and Kornicka, K.
- Published
- 2019
- Full Text
- View/download PDF
12. Use of principle component analysis to quantitatively score the equine metabolic syndrome phenotype in an Arabian horse population.
- Author
-
Lewis, Samantha L., Holl, Heather M., Long, Maureen T., Mallicote, Martha F., and Brooks, Samantha A.
- Subjects
EQUINE metabolic syndrome ,MULTIPLE correspondence analysis (Statistics) ,PHENOTYPES ,PERIODIC health examinations ,REGRESSION analysis ,DIAGNOSIS - Abstract
Equine metabolic syndrome (EMS), like human metabolic syndrome, comprises a collection of clinical signs related to obesity, insulin dysregulation and susceptibility to secondary inflammatory disease. Although the secondary conditions resulting from EMS can be life-threatening, diagnosis is not straightforward and often complicated by the presence of other concurrent conditions like pituitary pars intermedia dysfunction (PPID). In order to better characterize EMS, we sought to describe the variation within, and correlations between, typical physical and endocrine parameters for EMS. Utilizing an unsupervised statistical approach, we evaluated a population of Arabian horses using a physical examination including body measurements, as well as blood plasma insulin, leptin, ACTH, glucose, and lipid values. We investigated the relationships among these variables using principle component analysis (PCA), hierarchical clustering, and linear regression. Owner-assigned assessments of body condition were one full score (on a nine-point scale) lower than scores assigned by researchers, indicating differing perception of healthy equine body weight. Rotated PCA defined two factor scores explaining a total of 46.3% of variation within the dataset. Hierarchical clustering using these two factors revealed three groups corresponding well to traditional diagnostic categories of “Healthy”, “PPID-suspect”, and “EMS-suspect” based on the characteristics of each group. Proxies estimating up to 93.4% of the composite “EMS-suspect” and “PPID-suspect” scores were created using a reduced set of commonly used diagnostic variables, to facilitate application of these quantitative scores to horses of the Arabian breed in the field. Use of breed-specific, comprehensive physical and endocrinological variables combined in a single quantitative score may improve detection of horses at-risk for developing EMS, particularly in those lacking severe clinical signs. Quantification of EMS without the use of predetermined reference ranges provides an advantageous approach for future studies utilizing genomic or metabolomics approaches to improve understanding of the etiology behind this troubling condition. [ABSTRACT FROM AUTHOR]
- Published
- 2018
- Full Text
- View/download PDF
13. La deformación del borde dorsal del cuello y la influencia del ambiente.
- Author
-
Morales Briceño, A., Méndez Angulo, J. L., Méndez Sánchez, A., and Pérez Arévalo, J.
- Abstract
Copyright of Revista Complutense de Ciencias Veterinarias is the property of Universidad Complutense de Madrid and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2018
- Full Text
- View/download PDF
14. Influence of feeding a fish oil-containing diet to mature, overweight dogs: Effects on lipid metabolites, postprandial glycaemia and body weight.
- Author
-
de Godoy, M. R. C., McLeod, K. R., and Harmon, D. L.
- Subjects
FISH oils as feed ,DOG food ,ANIMAL health ,DOGS ,METABOLITES ,GLYCEMIC control - Abstract
The objective of this study was to determine the effect of feeding a fish oil (FO)-containing diet on lipid and protein metabolism, postprandial glycaemia and body weight (BW) of mature, overweight dogs. Seven female dogs were randomly assigned to one of two isonitrogenous and isocaloric diets, control ( CO) or FO ( FO), in a crossover design. Experimental periods were 69 day, separated by a washout period of 30 day. At the beginning of the experiment, and at 30 and 60 day of feeding the experimental diets, the dogs were infused with D-glucose (2 g/kg BW) through an intravenous catheter. Blood samples were collected for 3 hr to perform a glucose tolerance test. Nitrogen balance measurements began at 06:30 on d 63 of each experimental period and ended at 06:30 on d 69. On d 66 of each period, a single dose (7.5 mg/kg) of
15 N-glycine was administered orally for determination of protein turnover. Incremental area under the curve and glucose concentration at peak did not differ between treatments or among sampling days within treatment. Glucose half-life tended to decrease ( p < .10) in the FO treatment on day 30 when compared to baseline (day 0). β-hydroxybutyrate, non-esterified fatty acid ( NEFA) and triglycerides did not differ within or between treatments. Cholesterol decreased ( p < .05) on the FO treatment on day 30, 60 and 69 when compared to day 0. High-density lipoprotein ( HDL) decreased ( p < .05) in the FO treatment on day 69 when compared to day 0. Body weight, food intake, faecal excretion, DM and N digestibilities, N balance and protein turnover were not different between diets. Overall, FO-containing diet decreases cholesterol in mature overweight dogs; however, further research is warranted to verify the effects of FO on glucose metabolism. [ABSTRACT FROM AUTHOR]- Published
- 2018
- Full Text
- View/download PDF
15. Equine Hoof Stem Progenitor Cells (HPC) CD29 + /Nestin + /K15 + - a Novel Dermal/epidermal Stem Cell Population With a Potential Critical Role for Laminitis Treatment.
- Author
-
Marycz K, Pielok A, and Kornicka-Garbowska K
- Subjects
- Animals, Horses, Integrin beta1, Keratins, Nestin, Foot Diseases therapy, Foot Diseases veterinary, Hoof and Claw cytology, Horse Diseases genetics, Horse Diseases therapy, Stem Cells cytology
- Abstract
Laminitis is a life threating, extremely painful and frequently recurrent disease of horses which affects hoof structure. It results from the disruption of blood flow to the laminae, contributing to laminitis and in severe separation of bone from the hoof capsule. Still, the pathophysiology of the disease remains unclear, mainly due to its complexity. In the light of the presented data, in the extremally difficult process of tissue structure restoration after disruption, a novel type of progenitor cells may be involved. Herein, we isolated and performed the initial characterization of stem progenitor cells isolated from the coronary corium of the equine feet (HPC). Phenotype of the cells was investigated with flow cytometry and RT-qPCR revealing the presence of nestin, CD29, and expression of progenitor cell markers including SOX2, OCT4, NANOG and K14. Morphology of HPC was investigated with light, confocal and SEM microscopes. Cultured cells were characterised by spindle shaped morphology, eccentric nuclei, elongated mitochondria, and high proliferation rate. Plasticity and multilineage differentiation potential was confirmed by specific staining and gene expression analysis. We conclude that HPC exhibit in vitro expansion and plasticity similar to mesenchymal stem cells, which can be isolated from the equine foot, and may be directly involved in the pathogenesis and recovery of laminitis. Obtained results are of importance to the field of laminitis treatment as determining the repairing cell populations could contribute to the discovery of novel therapeutic targets and agents including and cell-based therapies for affected animals., (© 2021. The Author(s).)
- Published
- 2021
- Full Text
- View/download PDF
16. Clinical nutrition counselling service in the veterinary hospital: retrospective analysis of equine patients and nutritional considerations.
- Author
-
Vergnano, D., Bergero, D., and Valle, E.
- Subjects
NUTRITION ,VETERINARY hospitals ,WEIGHT loss ,EPIDEMIOLOGY ,CLINICAL trials - Abstract
Nutrition plays a very important role in the healthy and in the ill horse. Although research in this field clearly shows that incorrect nutritional practices may lead to severe pathologies, inappropriate feeding plans often continue to be used. A clinical nutrition counselling ( CNC) service could thus be of great use to both horse owners and veterinarians. The aim of this study was to provide information on equine patients referred to the CNC service of the University of Turin and to provide standard dietary protocols as used in our Veterinary Teaching Hospital for the most common nutrition-related pathologies. The data were obtained by retrospective analysis of the nutritional records of referred equine patients. The data collected included information about anamnesis, nutritional assessment, current diet, referring person and follow-up of each patient. Sixty-one horses were included in the study. The majority were adult males. The most common breeds were the Italian Saddle Horse and the Friesian Horse. Old horses (>19 years) had a statistically lower BCS than brood mares or other adult horses (p < 0.01). The most common nutritional pathologies were chronic weight loss ( CWL), chronic diarrhoea ( CD) and equine gastric ulcer syndrome. All horses received first-cut meadow hay; 85% also ate concentrates. Young horses (<2 years) received more hay as a percentage of body weight ( BW) than old horses or adults. The hay percentage of BW per day given to animals with CWL was statistically higher than those with CD (p < 0.01). The concentrate percentage of BW given to old horses was statistically lower compared to that given to young horses (p < 0.05). The concentrate percentage of BW per day given to horses with colic was statistically higher than that given to horses with CD (p < 0.05). 28% of cases were referred by the owner and 72% by a veterinarian. Follow-up evaluation was deemed to be 'good' in 92% cases and 'poor' in 8%. In summary, the CNC service could provide an epidemiological observatory to study the prevalence of nutritional issues in the equine population. [ABSTRACT FROM AUTHOR]
- Published
- 2017
- Full Text
- View/download PDF
17. EFEITOS DA CLONIDINA E DA RILMENIDINA SOBRE OS SISTEMAS CARDIORRESPIRATÓRIO E GASTROINTESTINAL DE EQUINOS.
- Author
-
de Oliveira Alves, José Edgard, dos Santos, Scarlath Ohana Penna, Sartori, Fábio, and Flores Catelli, Marcelo
- Published
- 2016
- Full Text
- View/download PDF
18. Equine metabolic syndrome.
- Author
-
Morgan, R., Keen, J., and McGowan, C.
- Subjects
EQUINE metabolic syndrome ,LAMINITIS ,VETERINARY surgery ,VETERINARY medicine ,VETERINARIANS ,VETERINARY therapeutics ,HORSES - Abstract
Laminitis is one of the most common and frustrating clinical presentations in equine practice. While the principles of treatment for laminitis have not changed for several decades, there have been some important paradigm shifts in our understanding of laminitis. Most importantly, it is essential to consider laminitis as a clinical sign of disease and not as a disease in its own right. Once this shift in thinking has occurred, it is logical to then question what disease caused the laminitis. More than 90 per cent of horses presented with laminitis as their primary clinical sign will have developed it as a consequence of endocrine disease; most commonly equine metabolic syndrome (EMS). Given the fact that many horses will have painful protracted and/or chronic recurrent disease, a good understanding of the predisposing factors and how to diagnose and manage them is crucial. Current evidence suggests that early diagnosis and effective management of EMS should be a key aim for practising veterinary surgeons to prevent the devastating consequences of laminitis. This review will focus on EMS, its diagnosis and management. [ABSTRACT FROM AUTHOR]
- Published
- 2015
- Full Text
- View/download PDF
19. Obesity-related metabolic dysfunction in dogs: a comparison with human metabolic syndrome.
- Author
-
Tvarijonaviciute, Asta, Ceron, Jose J., Holden, Shelley L., Cuthbertson, Daniel J., Biourge, Vincent, Morris, Penelope J., and German, Alexander J.
- Subjects
METABOLIC syndrome ,CARDIOVASCULAR diseases ,OBESITY ,HYPERTENSION ,DOG diseases - Abstract
Background: Recently, metabolic syndrome (MS) has gained attention in human metabolic medicine given its associations with development of type 2 diabetes mellitus and cardiovascular disease. Canine obesity is associated with the development of insulin resistance, dyslipidaemia, and mild hypertension, but the authors are not aware of any existing studies examining the existence or prevalence of MS in obese dogs. Thirty-five obese dogs were assessed before and after weight loss (median percentage loss 29%, range 10-44%). The diagnostic criteria of the International Diabetes Federation were modified in order to define canine obesity-related metabolic dysfunction (ORMD), which included a measure of adiposity (using a 9-point body condition score [BCS]), systolic blood pressure, fasting plasma cholesterol, plasma triglyceride, and fasting plasma glucose. By way of comparison, total body fat mass was measured by dual-energy X-ray absorptiometry, whilst total adiponectin, fasting insulin, and high-sensitivity C-reactive protein (hsCRP) were measured using validated assays. Results: Systolic blood pressure (P = 0.008), cholesterol (P = 0.003), triglyceride (P = 0.018), and fasting insulin (P < 0.001) all decreased after weight loss, whilst plasma total adiponectin increased (P = 0.001). However, hsCRP did not change with weight loss. Prior to weight loss, 7 dogs were defined as having ORMD, and there was no difference in total fat mass between these dogs and those who did not meet the criteria for ORMD. However, plasma adiponectin concentration was less (P = 0.031), and plasma insulin concentration was greater (P = 0.030) in ORMD dogs. Conclusions: In this study, approximately 20% of obese dogs suffer from ORMD, and this is characterized by hypoadiponectinaemia and hyperinsulinaemia. These studies can form the basis of further investigations to determine path genetic mechanisms and the health significance for dogs, in terms of disease associations and outcomes of weight loss. [ABSTRACT FROM AUTHOR]
- Published
- 2012
- Full Text
- View/download PDF
20. Equine metabolic syndrome
- Author
-
Catherine M. McGowan, John Keen, and Ruth Morgan
- Subjects
medicine.medical_specialty ,congenital, hereditary, and neonatal diseases and abnormalities ,animal structures ,Disease ,Foot Diseases ,Recurrent disease ,Medicine ,Animals ,Horses ,Intensive care medicine ,Inflammation ,Metabolic Syndrome ,Endocrine disease ,General Veterinary ,integumentary system ,business.industry ,Research ,Effective management ,General Medicine ,Laminitis ,medicine.disease ,Surgery ,Early Diagnosis ,Equine metabolic syndrome ,embryonic structures ,Horse Diseases ,business - Abstract
Laminitis is one of the most common and frustrating clinical presentations in equine practice. While the principles of treatment for laminitis have not changed for several decades, there have been some important paradigm shifts in our understanding of laminitis. Most importantly, it is essential to consider laminitis as a clinical sign of disease and not as a disease in its own right. Once this shift in thinking has occurred, it is logical to then question what disease caused the laminitis. More than 90 per cent of horses presented with laminitis as their primary clinical sign will have developed it as a consequence of endocrine disease; most commonly equine metabolic syndrome (EMS). Given the fact that many horses will have painful protracted and/or chronic recurrent disease, a good understanding of the predisposing factors and how to diagnose and manage them is crucial. Current evidence suggests that early diagnosis and effective management of EMS should be a key aim for practising veterinary surgeons to prevent the devastating consequences of laminitis. This review will focus on EMS, its diagnosis and management.
- Published
- 2015
21. METABOLON, JOHNS HOPKINS, AND TUFTS TO DEVELOP KIDNEY FUNCTION TEST.
- Published
- 2016
22. PCR MARKET CLIMBS TO $3.5 BILLION.
- Published
- 2016
23. FOUNDATION MEDICINE AND ASTRAZENECA PARTNER TO CREATE CO-DX FOR CANCER DRUG.
- Published
- 2016
24. Evidence Based Equine Nutrition : A Practical Approach For Professionals
- Author
-
Teresa Hollands, Lizzie Drury, Teresa Hollands, and Lizzie Drury
- Subjects
- Horses--Nutrition, Horses--Feeding and feeds
- Abstract
This book uniquely provides both the scientific basis of equine nutrition and the translation of that science into practical, day-to-day feeding advice. It summarises the latest research to provide readers with the evidence base needed to both confidently advise those who want to understand the science behind equine nutrition, and apply that evidence into practical advice for anyone who just wants to know how to feed horses. Both veterinary and animal science courses struggle to provide adequate nutrition training within their syllabuses. Much of the general information available is poorly explained and not evidence based. This book fills that gap, with the author team relaying over 50 cumulative years'experience teaching equine nutrition to both practising clinicians and students. Find answers to the most common queries and challenges encountered during nutritional consultations across 17 informative chapters, using typical case-based examples as experienced by the authors. Fully supported throughout with visual aids and photographic illustrations, they show how to easily increase compliance and understanding. Key topics covered include: How to take a diet history, including which forage and concentrates are most appropriate, and how to interpret the information on feed labels; How to take the horse's history, including workload, body weight and body fat scoring; Supporting achievable and sustainable fat loss in overweight horses; Appropriate rations across a range of performance disciplines and for breeding horses; Appropriate feeds and supplements for competition, including how to recognise potential hazards, signs of quality and issues of feed safety; How to use ration programmes, including a range of frequently asked questions for horses with specific nutritional requirements from allergies to obesity. A recommended resource to support the teaching of veterinary nutrition, this book should also be found on the bookshelf of all veterinarians, animal scientists, trainers, nutritionists, and nutritional advisors. This book includes forewords by Carl Lester, Honorary Fellow of the British Horse Society and recipient of an MBE for his services to Equestrianism, and Tim Mair, former President of the British Equine Veterinary Association.
- Published
- 2023
25. In Vitro Generated Equine Hepatic-Like Progenitor Cells as a Novel Potent Cell Pool for Equine Metabolic Syndrome (EMS) Treatment
- Author
-
Marycz, Krzysztof, Bourebaba, Nabila, Serwotka-Suszczak, Anna, Mularczyk, Malwina, Galuppo, Larry, and Bourebaba, Lynda
- Published
- 2023
- Full Text
- View/download PDF
26. Equine Endocrinology
- Author
-
François-René Bertin, Natalie S Fraser, François-René Bertin, and Natalie S Fraser
- Subjects
- Veterinary endocrinology, Horses--Diseases
- Abstract
This book provides a practical, clinical approach to diagnosing, treating, and managing endocrine diseases in the horse. Each chapter uses the same structure to form a user-friendly tool of information and advice on aetiology, pathophysiology, clinical presentation, diagnosis and treatment for each endocrine disorder. This book covers: - approaches to endocrine disorders; - diseases of the hypothalamo-pituitary-thyroid axis; - disorders in calcium regulation and diseases of the parathyroid gland; - diseases of the hypothalamo-pituitary-adrenocortical axes; - diseases of the endocrine pancreas and Equine Metabolic Syndrome; - hyperlipaemia and lipid metabolism disorders; and - endocrine disorders associated with the female and male reproductive systems. This book also includes material on additional endocrinopathies, such as diabetes insipidus and pheochromocytoma, and is dedicated to the fast-moving field of equine endocrinology. Written by world-leading international experts, it collates their insights and experience into approaches that prove invaluable for general equine practitioners.
- Published
- 2020
27. Food Biofortification Technologies
- Author
-
Agnieszka Saeid and Agnieszka Saeid
- Subjects
- Enriched foods, Food--Composition, Nutrition
- Abstract
Biofortification, which can be defined as the process of increasing the content/density of essential nutrients and/or its bioavailability of food with valuable compounds, is a promising means of increasing nutrient intakes. Traditional fortification practices in which exogenous nutrients are added to food can increase the content of nutrients but the use of biofortified foods with nutrients also may deliver the compounds in a more available form, as well as boost the overall relative effectiveness of these foods in raising nutrients status. Food Biofortification Technologies presents the state of the art in the field of novel methods of fortification and agricultural treatments as a way to improve the quality of obtained food products or compounds enriched with valuable nutrients. The book deals with fortification methods and agricultural treatments, which can improve the quality of food products or other agricultural compounds, providing them with a higher density of valuable nutrients. The utilization of novel products, such as feed additives and fertilizers, can avert nutrients depletion in food products. The book describes new and conventional methods of introducing valuable compounds into food components and presents the application of biosorption, bioaccumulation, and utilization of fertilizers in obtaining designer food. Attention is paid to the use of biomass as the carrier of nutrients such as microelements into the food components. The chapters are dedicated to specific food products and their nutrient components. The first chapter discusses the agronomic biofortification with micronutrients where the fertilization strategies are pointed out as a key to plant/cereals fortification. Other chapters present the fortification of animal foodstuffs such as meat, fish, milk, and eggs as well as the fortification of plant foodstuffs such as vegetables, fruits, and cereals. The book also explores advances in food fortification with vitamins and co-vitamins, essential minerals, essential fatty and amino acids, phytonutrients, and enzymes.
- Published
- 2018
28. Equine Applied and Clinical Nutrition : Health, Welfare and Performance
- Author
-
Raymond J. Geor, Patricia Harris, Manfred Coenen, Raymond J. Geor, Patricia Harris, and Manfred Coenen
- Subjects
- Horses--Feeding and feeds, Horses, Horses--Nutrition, Horses--Health, Feeds
- Abstract
Equine Applied and Clinical Nutrition is a comprehensive text resource on the nutrition and feeding management of horses. Over 20 experts from around the world share their wisdom on a topic of central relevance to all equine practitioners and the equine community generally. Both basic and applied (including healthy and diseased animals) nutrition and feeding management of horses and other equids (i.e. ponies, donkeys, wild equids) are covered. The book will appeal to a wide audienc: undergraduate and post-graduate students in equine science and veterinary medicine, veterinarians, equine nutritionists, horse trainers and owners. The clinical component will strengthen the appeal for equine veterinarians. Equine Applied and Clinical Nutrition will be a'must have'for anyone involved in the care of horses, ponies and other equids. The book is divided into 3 parts: Basic or core nutrition in this context refers to digestive physiology of the horse and the principles of nutrition. Applied nutrition deals with the particular types of foods, and how to maintain an optimum diet through various life stages of the horse. You might characterize this aspect as prevention of disease through diet. Clinical nutrition covers various diseases induced by poor diet, and their dietary treatment and management. It also looks at specific feeding regimes useful in cases disease not specifically induced by diet. Authoritative, international contributions Strong coverage of clinical aspects either omitted from or only sparsely dealt with elsewhere Full colour throughout The only clinical equine nutrition book
- Published
- 2013
29. Effects of a new intravenous electrolyte solution for veterinary therapy on the electrolyte and acid-base balances of healthy horses/Efeito de ma nova solucao eletrolitica intravenosa para uso veterinario sobre os equilibrios eletrolitico e acido base de equinos sadios
- Author
-
Pereira, Priscilla Fajardo Valente, Bessegatto, Jose Antonio, de Castro Bregadioli, Gabriela, Camilo, Stefany Lia Oliveira, de Sales, Nathali Adrielli Agassi, Flaiban, Karina Keller Marques da Costa, and Lisboa, Julio Augusto Naylor
- Published
- 2016
- Full Text
- View/download PDF
30. Glucose homeostasis and the enteroinsular axis in the horse a possible role in equine metabolic syndrome
- Author
-
LS Equine Internal Medicine, I&I AVM, Advances in Veterinary Medicine, de Graaf-Roelfsema, Ellen, LS Equine Internal Medicine, I&I AVM, Advances in Veterinary Medicine, and de Graaf-Roelfsema, Ellen
- Published
- 2014
31. Findings from University of Utrecht Provides New Data about Proinsulin
- Subjects
Insulin resistance ,Proteins ,Biological sciences ,Health - Abstract
By a News Reporter-Staff News Editor at Life Science Weekly -- Investigators publish new report on Peptide Proteins. According to news reporting originating in Utrecht, Netherlands, by NewsRx editors, the [...]
- Published
- 2014
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.