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6. Harnessing the potential of CAR-T cell therapy: progress, challenges, and future directions in hematological and solid tumor treatments.

Author

Dagar, Gunjan, Gupta, Ashna, Masoodi, Tariq, Nisar, Sabah, Merhi, Maysolun, Hashem, Sheema, Chauhan, Ravi, Dagar, Manisha, Mirza, Sameer, Bagga, Puneet, Kumar, Rakesh, Akil, Ammira S Al-Shabeeb, Macha, Muzafar A, Haris, Mohammad, Uddin, Shahab, Singh, Mayank, and Bhat, Ajaz A

Subjects
Humans, Neoplasms, Multiple Myeloma, Hematologic Neoplasms, Antigens, Neoplasm, Immunotherapy, Adoptive, Artificial Intelligence, Tumor Microenvironment, Cell- and Tissue-Based Therapy, Receptors, Chimeric Antigen, Antigen escape, CAR-T cell therapy, Cytokine release syndrome, Hematological malignancy, Immunotherapy, Solid tumor, Tumor antigens, Lymphoma, Biotechnology, Immunization, Hematology, Vaccine Related, Cancer, Rare Diseases, Genetics, Development of treatments and therapeutic interventions, 5.2 Cellular and gene therapies, Medical and Health Sciences, Immunology
Abstract

Traditional cancer treatments use nonspecific drugs and monoclonal antibodies to target tumor cells. Chimeric antigen receptor (CAR)-T cell therapy, however, leverages the immune system's T-cells to recognize and attack tumor cells. T-cells are isolated from patients and modified to target tumor-associated antigens. CAR-T therapy has achieved FDA approval for treating blood cancers like B-cell acute lymphoblastic leukemia, large B-cell lymphoma, and multiple myeloma by targeting CD-19 and B-cell maturation antigens. Bi-specific chimeric antigen receptors may contribute to mitigating tumor antigen escape, but their efficacy could be limited in cases where certain tumor cells do not express the targeted antigens. Despite success in blood cancers, CAR-T technology faces challenges in solid tumors, including lack of reliable tumor-associated antigens, hypoxic cores, immunosuppressive tumor environments, enhanced reactive oxygen species, and decreased T-cell infiltration. To overcome these challenges, current research aims to identify reliable tumor-associated antigens and develop cost-effective, tumor microenvironment-specific CAR-T cells. This review covers the evolution of CAR-T therapy against various tumors, including hematological and solid tumors, highlights challenges faced by CAR-T cell therapy, and suggests strategies to overcome these obstacles, such as utilizing single-cell RNA sequencing and artificial intelligence to optimize clinical-grade CAR-T cells.

Published
2023

7. Unleashing the Potential of Deep Learning for Precise Nuclei Segmentation and Classification in H &E-Stained Whole Slide Images

Author

Majeed, Tabasum, Aalam, Syed Wajid, Ahanger, Abdul Basit, Dar, Rayees Ahmad, Masoodi, Tariq Ahmad, Macha, Muzafar Ahmad, Bhat, Ajaz A., Bhat, Muzafar Rasool, Assad, Assif, Kacprzyk, Janusz, Series Editor, Gomide, Fernando, Advisory Editor, Kaynak, Okyay, Advisory Editor, Liu, Derong, Advisory Editor, Pedrycz, Witold, Advisory Editor, Polycarpou, Marios M., Advisory Editor, Rudas, Imre J., Advisory Editor, Wang, Jun, Advisory Editor, Pant, Millie, editor, Deep, Kusum, editor, and Nagar, Atulya, editor

Published
2024
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8. An integrated tumor, immune and microbiome atlas of colon cancer.

Author

Roelands, Jessica, Kuppen, Peter, Ahmed, Eiman, Mall, Raghvendra, Masoodi, Tariq, Singh, Parul, Monaco, Gianni, Raynaud, Christophe, de Miranda, Noel, Ferraro, Luigi, Carneiro-Lobo, Tatiana, Syed, Najeeb, Rawat, Arun, Awad, Amany, Decock, Julie, Mifsud, William, Miller, Lance, Sherif, Shimaa, Mohamed, Mahmoud, Rinchai, Darawan, Van den Eynde, Marc, Sayaman, Rosalyn, Ziv, Elad, Bertucci, Francois, Petkar, Mahir, Lorenz, Stephan, Mathew, Lisa, Wang, Kun, Murugesan, Selvasankar, Chaussabel, Damien, Vahrmeijer, Alexander, Wang, Ena, Ceccarelli, Anna, Fakhro, Khalid, Zoppoli, Gabriele, Ballestrero, Alberto, Tollenaar, Rob, Marincola, Francesco, Galon, Jérôme, Khodor, Souhaila, Ceccarelli, Michele, Hendrickx, Wouter, and Bedognetti, Davide

Subjects
Humans, Cohort Studies, Biomarkers, Tumor, Colonic Neoplasms, Transcriptome, Tumor Microenvironment
Abstract

The lack of multi-omics cancer datasets with extensive follow-up information hinders the identification of accurate biomarkers of clinical outcome. In this cohort study, we performed comprehensive genomic analyses on fresh-frozen samples from 348 patients affected by primary colon cancer, encompassing RNA, whole-exome, deep T cell receptor and 16S bacterial rRNA gene sequencing on tumor and matched healthy colon tissue, complemented with tumor whole-genome sequencing for further microbiome characterization. A type 1 helper T cell, cytotoxic, gene expression signature, called Immunologic Constant of Rejection, captured the presence of clonally expanded, tumor-enriched T cell clones and outperformed conventional prognostic molecular biomarkers, such as the consensus molecular subtype and the microsatellite instability classifications. Quantification of genetic immunoediting, defined as a lower number of neoantigens than expected, further refined its prognostic value. We identified a microbiome signature, driven by Ruminococcus bromii, associated with a favorable outcome. By combining microbiome signature and Immunologic Constant of Rejection, we developed and validated a composite score (mICRoScore), which identifies a group of patients with excellent survival probability. The publicly available multi-omics dataset provides a resource for better understanding colon cancer biology that could facilitate the discovery of personalized therapeutic approaches.

Published
2023

9. Alternative Splicing in Cancer Drug Resistance

Author

Gupta, Ashna, primary, Chauhan, Ravi, additional, Sharma, Tarang, additional, Macha, Muzafar A., additional, Masoodi, Tariq, additional, Al-Shabeeb Akil, Ammira S., additional, Bhat, Ajaz A., additional, and Singh, Mayank, additional

Published
2024
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11. Associations between telomere attrition, genetic variants in telomere maintenance genes, and non-small cell lung cancer risk in the Jammu and Kashmir population of North India

Author

Bhat, Gh. Rasool, Jamwal, Rajeshwer Singh, Sethi, Itty, Bhat, Amrita, Shah, Ruchi, Verma, Sonali, Sharma, Minerva, Sadida, Hana Q., Al-Marzooqi, Sara K., Masoodi, Tariq, Mirza, Sameer, Haris, Mohammad, Macha, Muzafar A., Akil, Ammira S. Alshabeeb, Bhat, Ajaz A., and Kumar, Rakesh

Published
2023
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13. Ubiquitin specific peptidase 37 and PCNA interaction promotes osteosarcoma pathogenesis by modulating replication fork progression

Author

Chauhan, Ravi, Gupta, Ashna, Malhotra, Lakshay, Bhat, Ajaz A., Pandita, Raj K., Masoodi, Tariq, Dagar, Gunjan, Sadida, Hana Q., Al-Marzooqi, Sara K., Batra, Atul, Bakhshi, Sameer, Sharma, Mehar Chand, Tanwar, Pranay, Khan, Shah Alam, Samath, Ethayathulla Abdul, Uddin, Shahab, Akil, Ammira S. Al-Shabeeb, Haris, Mohammad, Macha, Muzafar A., Pandita, Tej K., and Singh, Mayank

Published
2023
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14. Unraveling the Esophageal Cancer Tumor Microenvironment: Insights and Novel Immunotherapeutic Strategies

Author

Khan, Inamu Rashid, Ali, Faizyana, Hashem, Sheema, Abdulla, Alanoud, Nisar, Sabah, Masoodi, Tariq, Al-Shabeeb Akil, Ammira S., Bhat, Ajaz A., Macha, Muzafar A., Rezaei, Nima, Series Editor, Ahmed, Atif A., Editorial Board Member, Aguiar, Rodrigo, Editorial Board Member, Ambrosio, Maria R., Editorial Board Member, Artac, Mehmet, Editorial Board Member, Augustine, Tanya N., Editorial Board Member, Bambauer, Rolf, Editorial Board Member, Bhat, Ajaz Ahmad, Editorial Board Member, Bertolaccini, Luca, Editorial Board Member, Bianchini, Chiara, Editorial Board Member, Cavic, Milena, Editorial Board Member, Chakrabarti, Sakti, Editorial Board Member, Cho, William C. S., Editorial Board Member, Czarnecka, Anna M., Editorial Board Member, Domingues, Cátia, Editorial Board Member, Eşkazan, A. Emre, Editorial Board Member, Fares, Jawad, Editorial Board Member, Fonseca Alves, Carlos E., Editorial Board Member, Fru, Pascaline, Editorial Board Member, Da Gama Duarte, Jessica, Editorial Board Member, García, Mónica C., Editorial Board Member, Gener, Melissa A.H., Editorial Board Member, Estrada Guadarrama, José Antonio, Editorial Board Member, Hargadon, Kristian M., Editorial Board Member, Holvoet, Paul, Editorial Board Member, Jurisic, Vladimir, Editorial Board Member, Kabir, Yearul, Editorial Board Member, Katsila, Theodora, Editorial Board Member, Kleeff, Jorg, Editorial Board Member, Liang, Chao, Editorial Board Member, Tan, Mei Lan, Editorial Board Member, Li, Weijie, Editorial Board Member, Prado López, Sonia, Editorial Board Member, Macha, Muzafar A., Editorial Board Member, Malara, Natalia, Editorial Board Member, Orhan, Adile, Editorial Board Member, Prado-Garcia, Heriberto, Editorial Board Member, Pérez-Velázquez, Judith, Editorial Board Member, Rashed, Wafaa M., Editorial Board Member, Sanguedolce, Francesca, Editorial Board Member, Sorrentino, Rosalinda, Editorial Board Member, Shubina, Irina Zh., Editorial Board Member, de Araujo, Heloisa Sobreiro Selistre, Editorial Board Member, Torres-Suárez, Ana Isabel, Editorial Board Member, Włodarczyk, Jakub, Editorial Board Member, Yeong, Joe Poh Sheng, Editorial Board Member, Toscano, Marta A., Editorial Board Member, Wong, Tak-Wah, Editorial Board Member, Yin, Jun, Editorial Board Member, and Yu, Bin, Editorial Board Member

Published
2023
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15. Tight Junctions and Signaling Pathways in Cancer

Author

Khurshid, Sana, UlHaq, Burhan, Khursheed, Sadaf, Sadida, Hana Q., Masoodi, Tariq, Singh, Mayank, Akil, Ammira S. Al-Shabeeb, Bhat, Ajaz A., Macha, Muzafar A., Bhat, Ajaz A., editor, Haris, Mohammad, editor, Macha, Muzafar A., editor, and Dhawan, Punita, editor

Published
2023
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16. Molecular Architecture and Function of Tight Junctions

Author

Kumar, Mudasir A., Khan, Tulaib Azam, Al Marzooqi, Sara K., Abdulla, Alanoud, Masoodi, Tariq, Akil, Ammira S. Al-Shabeeb, Bhat, Ajaz A., Macha, Muzafar A., Bhat, Ajaz A., editor, Haris, Mohammad, editor, Macha, Muzafar A., editor, and Dhawan, Punita, editor

Published
2023
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18. Imaging Techniques to Study Tight Junctions

Author

Ali, Tayyiba Akbar, Akhtar, Sabah, Nisar, Sabah, Masoodi, Tariq, Reddy, Ravinder, Bhat, Ajaz A., Haris, Mohammad, Bhat, Ajaz A., editor, Haris, Mohammad, editor, Macha, Muzafar A., editor, and Dhawan, Punita, editor

Published
2023
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24. SORBS1 expression as a biomarker for obesity and breast cancer prognosis: Insights from genomic analysis and survival outcomes.

Author

Bhat, Ajaz Ahmad, primary, Ahmed, Ikhlak, additional, Usmani, Shahabuddin, additional, Sadida, Hana. Q., additional, Masoodi, Tariq, additional, Kumar, Rakesh, additional, Singh, Mayank, additional, Mir, Manzoor Ahmad, additional, Mirza, Sameer, additional, Uddin, Shahab, additional, Macha, Muzafar Ahmad, additional, and Al-Shabeeb Akil, Ammira S, additional

Published
2024
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45. Abstract 335: Ubiquitin Specific Peptidase 37promotes Osteosarcoma oncogenesis by interacting with PCNA and impacting constitutive replication fork movement.

Author

Chauhan, Ravi, primary, Malhotra, Lakshay, additional, Gupta, Ashna, additional, Bhat, Ajaz, additional, Dagar, Gunjan, additional, Masoodi, Tariq, additional, Macha, Muzafar A., additional, Samath, Ethayathulla Abdul, additional, Batra, Atul, additional, Sharma, Mehar Chand, additional, Haris, Mohammad, additional, Akil, Ammira Al-Shabeeb, additional, Pandita, Tej K., additional, Uddin, Shahab, additional, and Singh, Mayank, additional

Published
2023
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46. Supplementary Table S4 from TGFβ-induced SMAD4-dependent Apoptosis Proceeded by EMT in CRC

Author

Siraj, Abdul K., primary, Pratheeshkumar, Poyil, primary, Divya, Sasidharan Padmaja, primary, Parvathareddy, Sandeep Kumar, primary, Bu, Rong, primary, Masoodi, Tariq, primary, Kong, Yan, primary, Thangavel, Saravanan, primary, Al-Sanea, Nasser, primary, Ashari, Luai H., primary, Abduljabbar, Alaa, primary, Al-Homoud, Samar, primary, Al-Dayel, Fouad, primary, and Al-Kuraya, Khawla S., primary

Published
2023
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47. Supplementary Figure S1 from TGFβ-induced SMAD4-dependent Apoptosis Proceeded by EMT in CRC

Author

Siraj, Abdul K., primary, Pratheeshkumar, Poyil, primary, Divya, Sasidharan Padmaja, primary, Parvathareddy, Sandeep Kumar, primary, Bu, Rong, primary, Masoodi, Tariq, primary, Kong, Yan, primary, Thangavel, Saravanan, primary, Al-Sanea, Nasser, primary, Ashari, Luai H., primary, Abduljabbar, Alaa, primary, Al-Homoud, Samar, primary, Al-Dayel, Fouad, primary, and Al-Kuraya, Khawla S., primary

Published
2023
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48. Supplementary Materials and Methods from TGFβ-induced SMAD4-dependent Apoptosis Proceeded by EMT in CRC

Author

Siraj, Abdul K., primary, Pratheeshkumar, Poyil, primary, Divya, Sasidharan Padmaja, primary, Parvathareddy, Sandeep Kumar, primary, Bu, Rong, primary, Masoodi, Tariq, primary, Kong, Yan, primary, Thangavel, Saravanan, primary, Al-Sanea, Nasser, primary, Ashari, Luai H., primary, Abduljabbar, Alaa, primary, Al-Homoud, Samar, primary, Al-Dayel, Fouad, primary, and Al-Kuraya, Khawla S., primary

Published
2023
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49. Analysis of the Inhibitory Effect of Flavonoids on H-Ras Protein: An Anticancer Drug Target

Author

Alhamdan, Adel A. and Masoodi, Tariq Ahmad

Abstract

Background: GTP-bound mutant forms of H-Ras (Harvey-Ras) proteins are found in almost 30 of human tumors. In the present in silico study, the inhibitory effect of different flavonoid compounds on mutant H-Ras protein p21 has been assessed. The inhibitory effect of flavonoids is compared with three known clinical anticancer drugs. Besides, these have been interacted with normal H-Ras and tumor necrosis factor (TNF) proteins for toxicity check. Results: Upon docking, it was found that flavonoids such as naringenin, daidzein, and hesperetin showed highest affinity (most negative ΔG), while rutin showed no affinity towards mutant H-Ras. The three clinical anticancer agents (erlotinib, letrozole and exemestane) showed binding energies in the range of –1.11 to –5.51 kcal/mol which is comparatively lower than the flavonoids indicating efficacy of flavonoids to prevent complex formation with Raf and thereby prevent downstream effects. However, flavonoids showed no interaction with normal H-Ras and TNF indicating little or no cytotoxicity. Conclusion: Our study demonstrates that flavonoids (naringenin, daidzein, and hesperetin) are effective drugs to inhibit complex formation between mutant H-Ras P21 and RBD of Raf.

Published
2024
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