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In this paper we present some preliminary remarks on the preparation of a morphosyntactically annotated treebank for Saho within the Universal Dependencies (UD) framework, an annotation scheme used in a large collection of corpora, where Cushitic languages are still marginally represented. We discuss some issues concerning tokenization, morphology, and syntax, with particular reference to cases where deviations from the descriptions proposed in the literature on Saho are deemed necessary, in order to accommodate Saho data within the UD architecture, and cases where some peculiarities of the Saho language require an expansion of the inventories put forward in UD. [ABSTRACT FROM AUTHOR]

We described the case of a patient affected by activated PI3K-kinase delta syndrome (APDS) and a long-lasting and pauci-symptomatic SARS-CoV-2 infection, treated with multiple therapeutic agents including remdesivir and SARS-CoV-2-neutralizing monoclonal antibodies. We detected the clearance of the virus 105 days from the first positive swab and 7 days after monoclonal antibody administration. At genotyping, the SARS-CoV-2 virus resulted as wild type on all samples tested. This case shows the monoclonal antibodies' good tolerability and efficacy in reducing viral shedding in long-lasting infections refractory to other treatments. [ABSTRACT FROM AUTHOR]

Background. Breastfeeding imparts beneficial immune protection and nutrition to infants for healthy growth, but it is also a route for human immunodeficiency virus (HIV) and human cytomegalovirus (HCMV) infection. In previous studies, we showed that HCMV adversely affects infant development in Africa, particularly with maternal HIV exposure. In this study, we analyzed infants risks for acquisition of HCMV infection from breastfeeding and compared HIV-positive and HIV-negative mothers. Methods. Two cohorts were studied in Zambia. (1) Two hundred sixty-one HIV-infected and HIV-uninfected mothers were compared for HCMV deoxyribonucleic acid (DNA) loads and genotypes (glycoprotein gO) in milk from birth to 4 months postpartum. (2) Maternally HIV-exposed and HIV-unexposed infants were compared for HCMV infection risk factors. The second cohort of 460 infants, from a trial of micronutrientfortified complementary-food to breastfeeding, were studied between 6 and 18 months of age. Human cytomegalovirus seroprevalence was assayed, and logistic regression was used to calculate risk factors for HCMV infection, including maternal HIV exposure and breastfeeding duration. Results. Human cytomegalovirus was detected in breast milk from 3 days to 4 months postpartum, with significantly raised levels in HIV-positive women and independent of genotype. In infants, HCMV antibody seroprevalence was 83% by 18months age. Longer breastfeeding duration increased infection risk in maternally HIV-unexposed (odds ratio [OR] = 2.69 for 18 months vs <12 months; 95% confidence interval [CI], 0.84-8.59; P = .03) and HIV-exposed infants (OR = 20.37 for >6 months vs never; 95% CI, 3.71-111.70; P < .001). Conclusions. Prolonged breastfeeding, which is common in Africa, increased risk of HCMV infection in infants. Both HIV-positive and HIV-negative women had extended milk HCMV secretion. Women who were HIV-positive secreted higher HCMV levels, and for longer duration, with their children at increased infection risk. Human cytomegalovirus control is required to maintain health benefits of breastfeeding. [ABSTRACT FROM AUTHOR]

Background. Human immunodeficiency virus (HIV) and human cytomegalovirus (HCMV) coinfections have been shown to increase infant morbidity, mortality, and AIDS progression. In HIV-endemic regions, maternal HIV-exposed but HIV-uninfected infants, which is the majority of children affected by HIV, also show poor growth and increased morbidity. Although nutrition has been examined, the effects of HCMV infection have not been evaluated. We studied the effects of HCMV infection on the growth, development, and health of maternally HIVexposed and unexposed infants in Zambia. Methods. Infants were examined in a cohort recruited to a trial of micronutrient-fortified complementary foods. HIV-infected mothers and infants had received perinatal antiretroviral therapy to prevent mother-to-child HIV transmission. Growth, development, and morbidity were analyzed by linear regression analyses in relation to maternal HIV exposure and HCMV infection, as screened by sera DNA for viremia at 6 months of age and by antibody for infection at 18 months. Results. All HCMV-seropositive infants had decreased length-for-age by 18 months compared with seronegative infants (standard deviation [z]-score difference: -0.44 [95% confidence interval {CI}, -.72 to -.17]; P = .002). In HIV-exposed infants, those who were HCMV positive compared with those who were negative, also had reduced head size (mean z-score difference: -0.72 [95% CI, -1.23 to -.22]; P = .01) and lower psychomotor development (Bayley test score difference: -4.1 [95% CI, -7.8 to -.5]; P = .03). HIV-exposed, HCMV-viremic infants were more commonly referred for hospital treatment than HCMV-negative infants. The effects of HCMV were unaffected by micronutrient fortification. Conclusion. HCMV affects child growth, development, and morbidity of African infants, particularly in those maternally exposed to HIV. HCMV is therefore a risk factor for child health in this region. [ABSTRACT FROM AUTHOR]

Aim To provide accurate but parsimonious quantitative descriptions of clines in cranial form of red colobus, to partition morphological variance into geographical, taxonomic and structured taxonomic components, and to visually summarize clines in multivariate shape data using a method which produces results directly comparable to both univariate studies of geographical variation and standard geometric morphometric visualization of shape differences along vectors. Location Equatorial Africa. Methods Sixty-four three-dimensional cranial landmarks were measured on 276 adult red colobus monkeys sampled over their entire distribution. Geometric morphometric methods were applied, and size and shape variables regressed onto geographical coordinates using linear and curvilinear models. Model selection was done using the second-order Akaike information criterion. Components of variation related to geography, taxon or their combined effect were partitioned using partial regresssion. Multivariate trends in clinal shape were summarized using principal components of predictions from regressions, plotting vector scores on maps as for univariate size, and visualizing differences along main axes of clinal shape variation using surface rendering. Results Significant clinal variation was found in size and shape. Clines were similar in females and males. Trend surface analysis tended to be more accurate and parsimonious than alternative models in predicting morphology based on geography. Cranial form was relatively paedomorphic in East Africa and peramorphic in central Africa. Most taxonomic variation was geographically structured. However, taxonomic differences alone accounted for a larger proportion of total explained variance in shape (up to 40%) than in size (≤ 20%). Main conclusions A strong cline explained most of the observed size variation and a significant part of the shape differences of red colobus crania. The pattern of geographical variation was largely similar to that previously reported in vervets, despite different habitat preferences (arboreal versus terrestrial) and a long period since divergence ( c. 14–15 Myr). This suggests that some aspects of morphological divergence in both groups may have been influenced by similar environmental, geographical and historical factors. Cranial size is likely to be evolutionarily more labile and thus better reflects the influence of recent environmental changes. Cranial shape could be more resilient to change and thus better reflects phylogenetically informative differences. [ABSTRACT FROM AUTHOR]

In a prospective study of acute pharyngitis in Italian children, 69 (38.3%) of 180 isolates of Streptococcus pyogenes were resistant to macrolides. S. pyogenes was eradicated in 12 (63.1%) of 19 patients with erythromycin-resistant S. pyogenes treated with clarithromycin and in 22 (88%) of 25 patients with erythromycin-susceptible strains. The constitutive-resistant phenotype was correlated with failure of macrolide treatment. [ABSTRACT FROM AUTHOR]