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2. HHV-6 reactivation as a cause of fever in autologous hematopoietic stem cell transplant recipients

Author

Catherine Thieblemont, Jérôme LeGoff, M. Lafaurie, S. Amorim, Maud Salmona, and M.A. Colombier

Subjects
0301 basic medicine, Microbiology (medical), Adult, Male, medicine.medical_specialty, Fever, Lymphoma, medicine.medical_treatment, Herpesvirus 6, Human, 030106 microbiology, Roseolovirus Infections, Hematopoietic stem cell transplantation, Gastroenterology, 03 medical and health sciences, Immunocompromised Host, Internal medicine, medicine, Humans, Whole blood, Aged, Retrospective Studies, business.industry, Hematopoietic Stem Cell Transplantation, Hematopoietic stem cell, Middle Aged, medicine.disease, Rash, Transplant Recipients, Regimen, Diarrhea, Pneumonia, Infectious Diseases, medicine.anatomical_structure, Immunology, Female, Virus Activation, medicine.symptom, business
Abstract

Summary Objectives We report the biological and clinical impacts possibly associated with HHV-6 reactivation in autologous hematopoietic stem cell transplant (AHSCT) recipients after intensive chemotherapy regimen for lymphoma. Methods We retrospectively reviewed clinical, biological, radiological, treatment and outcomes of patients with positive HHV-6 DNA in whole blood following autologous hematopoietic stem cell transplantation. Results Blood HHV-6 reactivation was reported in 27 (8.5%) patients among 316 AHSCT recipients after high dose therapy for lymphoma. Thirteen (4.1%) patients were symptomatic with fever (100%), diarrhea (61.5%), skin rash (46.1%), and pneumonia (23.1%). Antiviral treatment was administered in 9 (69%) patients and outcome was favorable in all cases. Conclusion Our study suggests a possible pathogenic role of HHV-6 in AHSCT recipients and suggests an impact of antiviral treatments on viral replication and clinical signs resolution.

Published
2016

5. Recent Findings in Human Herpesvirus 6 Described by Researchers from St. Louis Hospital (HHV-6 reactivation as a cause of fever in autologous hematopoietic stem cell transplant recipients)

Subjects
Research, Physical fitness -- Research, Hematopoietic stem cell transplantation -- Research, Stem cells -- Research, Stem cell research -- Research
Abstract

2017 AUG 5 (NewsRx) -- By a News Reporter-Staff News Editor at Obesity, Fitness & Wellness Week -- New research on Human Herpesvirus Diseases and Conditions - Human Herpesvirus 6 [...]

Published
2017

6. New Kidney Transplants Findings Reported from APHP (Dual Invasive Infection with Phaeoacremonium parasiticum and Paraconiothyrium cyclothyrioides in a Renal Transplant Recipient: Case Report and Comprehensive Review of the Literature of ...)

Subjects
Health aspects, Kidney transplantation -- Health aspects, Medical research -- Health aspects, Infection -- Health aspects
Abstract

2016 APR 24 (NewsRx) -- By a News Reporter-Staff News Editor at Medical Devices & Surgical Technology Week -- A new study on Transplant Medicine is now available. According to [...]

Published
2016

7. Researchers from Public Hospital System Report New Studies and Findings in the Area of Antifungals (Dual Invasive Infection with Phaeoacremonium parasiticum and Paraconiothyrium cyclothyrioides in a Renal Transplant Recipient: Case Report and ...)

Subjects
Public Hospital, Research, Health aspects, Antifungal agents -- Research -- Health aspects, Kidney transplantation -- Health aspects, Medical research -- Health aspects, Infection -- Research -- Health aspects
Abstract

2015 AUG 23 (NewsRx) -- By a News Reporter-Staff News Editor at Medical Devices & Surgical Technology Week -- Current study results on Drugs and Therapies have been published. According [...]

Published
2015

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