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How do people establish and maintain cultural fit with an organization? Prior research has offered two perspectives that have heretofore been conceptually disconnected. One focuses on personal values, whereas another emphasizes perceptions of the cultural code. We develop a theoretical account that integrates these approaches by linking them to distinct mechanisms and behavioral consequences of cultural fit. We propose that value congruence—the match between one’s values and those that prevail in an organization—relates to the mechanism of group attachment and shapes behavior when one periodically steps back from day-to-day interactions, assesses one’s identification with an organization, and determines whether to stay or voluntarily depart. In contrast, we argue that perceptual congruence—the degree to which one implicitly understands an organization’s prevailing values and norms—relates to the mechanism of interpersonal coordination and influences behavior when one engages in routine peer interactions. Accordingly, we theorize that these two forms of cultural fit relate to distinct behaviors, voluntary exit and linguistic conformity with peers, respectively. Drawing on email and survey data from a midsized technology firm, we find support for our theory and discuss the implications of our findings for research on person-culture fit, dual-process models of culture and cognition, and the pairing of surveys with digital trace data. Funding: This work was supported by the Berkeley Culture Center, the Cortese Distinguished Chair in Management, the Grether Chair of Business Administration and Public Policy.

The surgical approach to facial rejuvenation has evolved significantly over the last century. As surgeons have deepened their understanding of facial anatomy over the last half century, so have their surgical approaches to the rhytidectomy, with increasingly extensive manipulation of the underlying soft tissue in the face. While these procedures have become more comprehensive and natural in their approach, the risk of temporary facial palsy also appears to be on the rise. In this text, we review the technique for deep plane facelifts and neck contouring with an emphasis on the facial nerve anatomy and methods to preserve the intricate facial nerve network during tissue dissection and modification. Careful execution of the surgical steps involved, including deep neck contouring, SMAS (superficial musculoaponeurotic system) suspension, and skin management, is essential to achieve the authentic aesthetic outcomes that patients desire while ensuring patient safety. [ABSTRACT FROM AUTHOR]

BackgroundElectronic medical records (EMRs) contain vast amounts of data that is of great interest to physicians, clinical researchers, and medial policy makers. As the size, complexity, and accessibility of EMRs grow, the ability to extract meaningful information from them has become an increasingly important problem to solve.MethodsWe develop a standardized data analysis process to support cohort study with a focus on a particular disease. We use an interactive divide-and-conquer approach to classify patients into relatively uniform within each group. It is a repetitive process enabling the user to divide the data into homogeneous subsets that can be visually examined, compared, and refined. The final visualization was driven by the transformed data, and user feedback direct to the corresponding operators which completed the repetitive process. The output results are shown in a Sankey diagram-style timeline, which is a particular kind of flow diagram for showing factors' states and transitions over time.ResultsThis paper presented a visually rich, interactive web-based application, which could enable researchers to study any cohorts over time by using EMR data. The resulting visualizations help uncover hidden information in the data, compare differences between patient groups, determine critical factors that influence a particular disease, and help direct further analyses. We introduced and demonstrated this tool by using EMRs of 14,567 Chronic Kidney Disease (CKD) patients.ConclusionsWe developed a visual mining system to support exploratory data analysis of multi-dimensional categorical EMR data. By using CKD as a model of disease, it was assembled by automated correlational analysis and human-curated visual evaluation. The visualization methods such as Sankey diagram can reveal useful knowledge about the particular disease cohort and the trajectories of the disease over time.

UnlabelledEvents during primary HIV-1 infection have been shown to be critical for the subsequent rate of disease progression. Early control of viral replication, resolution of clinical symptoms and development of a viral set point have been associated with the emergence of HIV-specific CD8 T cell responses. Here we assessed which particular HIV-specific CD8 T cell responses contribute to long-term control of HIV-1. A total of 620 individuals with primary HIV-1 infection were screened by gamma interferon (IFN-γ) enzyme-linked immunospot (ELISPOT) assay for HLA class I-restricted, epitope-specific CD8 T cell responses using optimally defined epitopes approximately 2 months after initial presentation. The cohort was predominantly male (97%) and Caucasian (83%) (Fiebig stages II/III [n = 157], IV [n = 64], V [n = 286], and VI [n = 88] and Fiebig stage not determined [n = 25]). Longitudinal viral loads, CD4 count, and time to ART were collected for all patients. We observed strong associations between viral load at baseline (initial viremia) and the established early viral set points (P < 0.0001). Both were significantly associated with HLA class I genotypes (P = 0.0009). While neither the breadth nor the magnitude of HIV-specific CD8 T cell responses showed an influence on the early viral set point, a broader HIV-specific CD8 T cell response targeting epitopes within HIV-1 Gag during primary HIV-1 infection was associated with slower disease progression. Moreover, the induction of certain HIV-specific CD8 T cell responses--but not others--significantly influenced the time to ART initiation. Individual epitope-specific CD8 T cell responses contribute significantly to HIV-1 disease control, demonstrating that the specificity of the initial HIV-specific CD8 T cell response rather than the restricting HLA class I molecule alone is a critical determinant of antiviral function.ImportanceUnderstanding which factors are involved in the control of HIV-1 infection is critical for the design of therapeutic strategies for patients living with HIV/AIDS. Here, using a cohort of over 600 individuals with acute and early HIV-1 infection, we assessed in unprecedented detail the individual contribution of epitope-specific CD8 T cell responses directed against HIV-1 to control of viremia and their impact on the overall course of disease progression.

The San Francisco Bay Area has one of the most congested metropolitan corridors in both California and nationwide, with very high demand for both passenger and air-freight transport. It is also a main entrance to the United States for the huge Asia market, and thus critical for the United States to play a leading role in the global economy. On one hand, traffic congestion in the main corridors through the Bay Area is severe and is becoming worse with the rapid increase of population and the development of the local economy, in which a substantial impact is created by truck-related activities such as the ever increasing air freight business (performed by companies such as Federal Express, UPS, DHL, and CNF). On the other hand, the San Francisco Bay Area Rapid Transit District (BART) operates a regional environmentally-green transit system has excess capacity during non-commute periods and during the commute on some lines in some reverse-commute direction. If the BART system were to be used by the air-freight delivery service providers, BART could probably provide reliable service to integrated air freight carriers to meet their limited-time window delivery service needs. This would lead to additional revenue generation for BART. For the traveling public as well as local, regional, and state government it would reduce truck activity, and its corresponding negative impacts on traffic, environment, safety, land use and the economy. Using BART for air freight movement as a model for combined goods and passenger movement can be generalized to other critical corridors nationwide to effectively relieve corridor congestion problem. Improving movement through these critical metropolitan corridors could yield significant benefits in terms of reduced travel time and delays and increased reliability and predictability of both passenger and freight movement.

How do people establish and maintain cultural fit with an organization? Prior research has offered two perspectives that have heretofore been conceptually disconnected. One focuses on personal values, whereas another emphasizes perceptions of the cultural code. We develop a theoretical account that integrates these approaches by linking them to distinct mechanisms and behavioral consequences of cultural fit. We propose that value congruence—the match between one's values and those that prevail in an organization—relates to the mechanism of group attachment and shapes behavior when one periodically steps back from day-to-day interactions, assesses one's identification with an organization, and determines whether to stay or voluntarily depart. In contrast, we argue that perceptual congruence—the degree to which one implicitly understands an organization's prevailing values and norms—relates to the mechanism of interpersonal coordination and influences behavior when one engages in routine peer interactions. Accordingly, we theorize that these two forms of cultural fit relate to distinct behaviors, voluntary exit and linguistic conformity with peers, respectively. Drawing on email and survey data from a midsized technology firm, we find support for our theory and discuss the implications of our findings for research on person-culture fit, dual-process models of culture and cognition, and the pairing of surveys with digital trace data. Funding: This work was supported by the Berkeley Culture Center, the Cortese Distinguished Chair in Management, the Grether Chair of Business Administration and Public Policy. [ABSTRACT FROM AUTHOR]