15 results on '"Liu, Jason Z."'
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2. Uncommon Cause of Internal Mammary Artery Pseudoaneurysm
- Author
-
Prasad, Rohan M., primary, Liu, Jason Z., additional, Garces, Christopher, additional, Duwadi, Ayushma, additional, Choi, James, additional, Anwar, Farah, additional, and Olomu, Adesuwa, additional
- Published
- 2022
- Full Text
- View/download PDF
3. Dermatologic Manifestation of Acro-Ischemia Associated With COVID-19
- Author
-
Gumbita, Robert, primary, Liu, Jason Z., additional, Prasad, Rohan Madhu, additional, Radwan, Yasser, additional, and Nabeel, Muhammad, additional
- Published
- 2022
- Full Text
- View/download PDF
4. Effect of Five Genetic Variants Associated with Lung Function on the Risk of Chronic Obstructive Lung Disease, and Their Joint Effects on Lung Function
- Author
-
Artigas, María Soler, Wain, Louise V., Repapi, Emmanouela, Obeidat, Maʼen, Sayers, Ian, Burton, Paul R., Johnson, Toby, Zhao, Jing Hua, Albrecht, Eva, Dominiczak, Anna F., Kerr, Shona M., Smith, Blair H., Cadby, Gemma, Hui, Jennie, Palmer, Lyle J., Hingorani, Aroon D., Wannamethee, Goya S., Whincup, Peter H., Ebrahim, Shah, Smith, George Davey, Barroso, Inês, Loos, Ruth J. F., Wareham, Nicholas J., Cooper, Cyrus, Dennison, Elaine, Shaheen, Seif O., Liu, Jason Z., Marchini, Jonathan, Dahgam, Santosh, Naluai, Åsa Torinsson, Olin, Anna-Carin, Karrasch, Stefan, Heinrich, Joachim, Schulz, Holger, McKeever, Tricia M., Pavord, Ian D., Heliövaara, Markku, Ripatti, Samuli, Surakka, Ida, Blakey, John D., Kähönen, Mika, Britton, John R., Nyberg, Fredrik, Holloway, John W., Lawlor, Debbie A., Morris, Richard W., James, Alan L., Jackson, Cathy M., Hall, Ian P., and Tobin, Martin D.
- Published
- 2011
- Full Text
- View/download PDF
5. Genome-Wide Joint Meta-Analysis of SNP and SNP-by-Smoking Interaction Identifies Novel Loci for Pulmonary Function
- Author
-
Sood, Akshay, Liu, Jason Z., Smolonska, Joanna, Burkart, Kristin M., Elliott, Paul, Manning, Alisa K., Imboden, Medea, Homuth, Georg, Loth, Daan W., Eijgelsheim, Mark, Zhao, Jing Hua, Aschard, Hugues, Janson, Christer, Smith, Albert V., Lohman, Kurt, Artigas, María Soler, Gu, Xiangjun, Tang, Wenbo, Zhai, Guangju, Hysi, Pirro G., Curjuric, Ivan, Wilk, Jemma B., Loos, Ruth J. F., Koch, Beate, McArdle, Wendy L., Harris, Tamara B., Henry, Amanda, Loehr, Laura R., Gharib, Sina A., Manichaikul, Ani, Hancock, Dana B., and Ramasamy, Adaikalavan
- Subjects
respiratory system ,respiratory tract diseases - Abstract
Genome-wide association studies have identified numerous genetic loci for spirometic measures of pulmonary function, forced expiratory volume in one second (FEV1), and its ratio to forced vital capacity (FEV1/FVC). Given that cigarette smoking adversely affects pulmonary function, we conducted genome-wide joint meta-analyses (JMA) of single nucleotide polymorphism (SNP) and SNP-by-smoking (ever-smoking or pack-years) associations on FEV1 and FEV1/FVC across 19 studies (total N = 50,047). We identified three novel loci not previously associated with pulmonary function. SNPs in or near DNER (smallest P JMA = 5.00×10−11), HLA-DQB1 and HLA-DQA2 (smallest P JMA = 4.35×10−9), and KCNJ2 and SOX9 (smallest P JMA = 1.28×10−8) were associated with FEV1/FVC or FEV1 in meta-analysis models including SNP main effects, smoking main effects, and SNP-by-smoking (ever-smoking or pack-years) interaction. The HLA region has been widely implicated for autoimmune and lung phenotypes, unlike the other novel loci, which have not been widely implicated. We evaluated DNER, KCNJ2, and SOX9 and found them to be expressed in human lung tissue. DNER and SOX9 further showed evidence of differential expression in human airway epithelium in smokers compared to non-smokers. Our findings demonstrated that joint testing of SNP and SNP-by-environment interaction identified novel loci associated with complex traits that are missed when considering only the genetic main effects.
- Published
- 2012
- Full Text
- View/download PDF
6. Ambient Fine Particulate Matter Induces Apoptosis of Endothelial Progenitor Cells Through Reactive Oxygen Species Formation.
- Author
-
Cui, Yuqi, Xie, Xiaoyun, Jia, Fengpeng, He, Jianfeng, Li, Zhihong, Fu, Minghuan, Hao, Hong, Liu, Ying, Liu, Jason Z., Cowan, Peter J., Zhu, Hua, Sun, Qinghua, and Liu, Zhenguo
- Subjects
PARTICULATE matter ,PROGENITOR cells ,APOPTOSIS ,REACTIVE oxygen species ,ENDOTHELIAL cells ,NEOVASCULARIZATION - Abstract
Background/Aims: Bone marrow (BM)-derived endothelial progenitor cells (EPCs) play a critical role in angiogenesis and vascular repair. Some environmental insults, like fine particulate matter (PM) exposure, significantly impair cardiovascular functions. However, the mechanisms for PM-induced adverse effects on cardiovascular system remain largely unknown. The present research was to study the detrimental effects of PM on EPCs and explore the potential mechanisms. Methods: PM was intranasal-distilled into male C57BL/6 mice for one month. Flow cytometry was used to measure the number of EPCs, apoptosis level of circulating EPCs and intracellular reactive oxygen species (ROS) formation. Serum TNF- α and IL-1β were measured using ELISA. To determine the role of PM-induced ROS in EPC apoptosis, PM was co-administrated with the antioxidant N-acetylcysteine (NAC) in wild type mice or used in a triple transgenic mouse line (TG) with overexpression of antioxidant enzyme network (AON) composed of superoxide dismutase (SOD)1, SOD3, and glutathione peroxidase (Gpx-1) with decreased in vivo ROS production. Results: PM treatment significantly decreased circulating EPC population, promoted apoptosis of EPCs in association with increased ROS production and serum TNF-α and IL-1β levels, which could be effectively reversed by either NAC treatment or overexpression of AON. Conclusion: PM exposure significantly decreased circulating EPCs population due to increased apoptosis via ROS formation in mice. © 2015 S. Karger AG, Basel [ABSTRACT FROM AUTHOR]
- Published
- 2015
- Full Text
- View/download PDF
7. Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function
- Author
-
Soler Artigas, María, Loth, Daan W, Wain, Louise V, Gharib, Sina A, Obeidat, Ma'en, Tang, Wenbo, Zhai, Guangju, Zhao, Jing Hua, Smith, Albert Vernon, Huffman, Jennifer E, Albrecht, Eva, Jackson, Catherine M, Evans, David M, Cadby, Gemma, Fornage, Myriam, Manichaikul, Ani, Lopez, Lorna M, Johnson, Toby, Aldrich, Melinda C, Aspelund, Thor, Barroso, Inês, Campbell, Harry, Cassano, Patricia A, Couper, David J, Eiriksdottir, Gudny, Franceschini, Nora, Garcia, Melissa, Gieger, Christian, Gislason, Gauti Kjartan, Grkovic, Ivica, Hammond, Christopher J, Hancock, Dana B, Harris, Tamara B, Ramasamy, Adaikalavan, Heckbert, Susan R, Heliövaara, Markku, Homuth, Georg, Hysi, Pirro G, James, Alan L, Jankovic, Stipan, Joubert, Bonnie R, Karrasch, Stefan, Klopp, Norman, Koch, Beate, Kritchevsky, Stephen B, Launer, Lenore J, Liu, Yongmei, Loehr, Laura R, Lohman, Kurt, Loos, Ruth JF, Lumley, Thomas, Al Balushi, Khalid A, Ang, Wei Q, Barr, R Graham, Beilby, John, Blakey, John D, Boban, Mladen, Boraska, Vesna, Brisman, Jonas, Britton, John R, Brusselle, Guy G, Cooper, Cyrus, Curjuric, Ivan, Dahgam, Santosh, Deary, Ian J, Ebrahim, Shah, Eijgelsheim, Mark, Francks, Clyde, Gaysina, Darya, Granell, Raquel, Gu, Xiangjun, Hankinson, John L, Hardy, Rebecca, Harris, Sarah E, Henderson, John, Henry, Amanda, Hingorani, Aroon D, Hofman, Albert, Holt, Patrick G, Hui, Jennie, Hunter, Michael L, Imboden, Medea, Jameson, Karen A, Kerr, Shona M, Kolcic, Ivana, Kronenberg, Florian, Liu, Jason Z, Marchini, Jonathan, McKeever, Tricia, Morris, Andrew D, Olin, Anna-Carin, Porteous, David J, Postma, Dirkje S, Rich, Stephen S, Ring, Susan M, Rivadeneira, Fernando, Rochat, Thierry, Sayer, Avan Aihie, Sayers, Ian, Sly, Peter D, Smith, George Davey, Sood, Akshay, Starr, John M, Uitterlinden, André G, Vonk, Judith M, Wannamethee, S Goya, Whincup, Peter H, Wijmenga, Cisca, Williams, O Dale, Wong, Andrew, Mangino, Massimo, Marciante, Kristin D, McArdle, Wendy L, Meibohm, Bernd, Morrison, Alanna C, North, Kari E, Omenaas, Ernst, Palmer, Lyle J, Pietiläinen, Kirsi H, Pin, Isabelle, Pola Sbreve Ek, Ozren, Pouta, Anneli, Psaty, Bruce M, Hartikainen, Anna-Liisa, Rantanen, Taina, Ripatti, Samuli, Rotter, Jerome I, Rudan, Igor, Rudnicka, Alicja R, Schulz, Holger, Shin, So-Youn, Spector, Tim D, Surakka, Ida, Vitart, Veronique, Völzke, Henry, Wareham, Nicholas J, Warrington, Nicole M, Wichmann, H-Erich, Wild, Sarah H, Wilk, Jemma B, Wjst, Matthias, Wright, Alan F, Zgaga, Lina, Zemunik, Tatijana, Pennell, Craig E, Nyberg, Fredrik, Kuh, Diana, Holloway, John W, Boezen, H Marike, Lawlor, Debbie A, Morris, Richard W, Probst-Hensch, Nicole, International Lung Cancer Consortium, GIANT consortium, Kaprio, Jaakko, Wilson, James F, Hayward, Caroline, Kähönen, Mika, Heinrich, Joachim, Musk, Arthur W, Jarvis, Deborah L, Gläser, Sven, Järvelin, Marjo-Riitta, Ch Stricker, Bruno H, Elliott, Paul, O'Connor, George T, Strachan, David P, London, Stephanie J, Hall, Ian P, Gudnason, Vilmundur, and Tobin, Martin D
- Abstract
Pulmonary function measures reflect respiratory health and are used in the diagnosis of chronic obstructive pulmonary disease. We tested genome-wide association with forced expiratory volume in 1 second and the ratio of forced expiratory volume in 1 second to forced vital capacity in 48,201 individuals of European ancestry with follow up of the top associations in up to an additional 46,411 individuals. We identified new regions showing association (combined P < 5 × 10(-8)) with pulmonary function in or near MFAP2, TGFB2, HDAC4, RARB, MECOM (also known as EVI1), SPATA9, ARMC2, NCR3, ZKSCAN3, CDC123, C10orf11, LRP1, CCDC38, MMP15, CFDP1 and KCNE2. Identification of these 16 new loci may provide insight into the molecular mechanisms regulating pulmonary function and into molecular targets for future therapy to alleviate reduced lung function.
- Published
- 2011
8. Abstract 272: Chronic Hyperlipidemia Alters the Population of Endothelial Progenitor Cells in Bone Marrow and Peripheral Circulation via Both ROS-dependent and Independent Mechanisms
- Author
-
Liu, Dylan Z, primary, Cui, Yuqi, additional, Liu, Jason Z, additional, Liu, Lingjuan, additional, Li, Xin, additional, Xiao, Yuan, additional, Zhang, Jia, additional, Xie, Xiaoyun, additional, Hao, Hong, additional, He, Guanglong, additional, Parthasarathy, Sampath, additional, and Zhu, Hua, additional
- Published
- 2015
- Full Text
- View/download PDF
9. Abstract 565: Ambient Fine Particulate Matter Decreases Endothelial Progenitor Cells Through Reactive Oxygen Species-mediated Apoptosis
- Author
-
Cui, Yuqi, primary, Xie, Xiaoyun, additional, Liu, Jason Z, additional, Jia, Fengpeng, additional, He, Jianfeng, additional, Hao, Hong, additional, Liu, Ying, additional, Cowan, Peter J, additional, Zhu, Hua, additional, Sun, Qinghua, additional, and Liu, Zhenguo, additional
- Published
- 2015
- Full Text
- View/download PDF
10. Genome-Wide Joint Meta-Analysis of SNP and SNP-by-Smoking Interaction Identifies Novel Loci for Pulmonary Function
- Author
-
Hancock, Dana B, Artigas, María Soler, Gharib, Sina A, Henry, Amanda, Manichaikul, Ani, Ramasamy, Adaikalavan, Loth, Daan W, Imboden, Medea, Koch, Beate, McArdle, Wendy L, Smith, Albert V, Smolonska, Joanna, Sood, Akshay, Tang, Wenbo, Wilk, Jemma B, Zhai, Guangju, Zhao, Jing Hua, Aschard, Hugues, Burkart, Kristin M, Curjuric, Ivan, Eijgelsheim, Mark, Elliott, Paul, Gu, Xiangjun, Harris, Tamara B, Janson, Christer, Homuth, Georg, Hysi, Pirro G, Liu, Jason Z, Loehr, Laura R, Lohman, Kurt, Loos, Ruth J F, Manning, Alisa K, Marciante, Kristin D, Obeidat, Ma'en, Postma, Dirkje S, Aldrich, Melinda C, Brusselle, Guy G, Chen, Ting-Hsu, Eiriksdottir, Gudny, Franceschini, Nora, Heinrich, Joachim, Rotter, Jerome I, Wijmenga, Cisca, Williams, O Dale, Bentley, Amy R, Hofman, Albert, Laurie, Cathy C, Lumley, Thomas, Morrison, Alanna C, Joubert, Bonnie R, Rivadeneira, Fernando, Couper, David J, Kritchevsky, Stephen B, Liu, Yongmei, Wjst, Matthias, Wain, Louise V, Vonk, Judith M, Uitterlinden, André G, Rochat, Thierry, Rich, Stephen S, Psaty, Bruce M, O'Connor, George T, North, Kari E, Mirel, Daniel B, Meibohm, Bernd, Launer, Lenore J, Khaw, Kay-Tee, Hartikainen, Anna-Liisa, Hammond, Christopher J, Gläser, Sven, Marchini, Jonathan, Kraft, Peter, Wareham, Nicholas J, Völzke, Henry, Stricker, Bruno H C, Spector, Timothy D, Probst-Hensch, Nicole M, Jarvis, Deborah, Jarvelin, Marjo-Riitta, Heckbert, Susan R, Gudnason, Vilmundur, Boezen, H Marike, Barr, R Graham, Cassano, Patricia A, Strachan, David P, Fornage, Myriam, Hall, Ian P, Dupuis, Josée, Tobin, Martin D, London, Stephanie J, Hancock, Dana B, Artigas, María Soler, Gharib, Sina A, Henry, Amanda, Manichaikul, Ani, Ramasamy, Adaikalavan, Loth, Daan W, Imboden, Medea, Koch, Beate, McArdle, Wendy L, Smith, Albert V, Smolonska, Joanna, Sood, Akshay, Tang, Wenbo, Wilk, Jemma B, Zhai, Guangju, Zhao, Jing Hua, Aschard, Hugues, Burkart, Kristin M, Curjuric, Ivan, Eijgelsheim, Mark, Elliott, Paul, Gu, Xiangjun, Harris, Tamara B, Janson, Christer, Homuth, Georg, Hysi, Pirro G, Liu, Jason Z, Loehr, Laura R, Lohman, Kurt, Loos, Ruth J F, Manning, Alisa K, Marciante, Kristin D, Obeidat, Ma'en, Postma, Dirkje S, Aldrich, Melinda C, Brusselle, Guy G, Chen, Ting-Hsu, Eiriksdottir, Gudny, Franceschini, Nora, Heinrich, Joachim, Rotter, Jerome I, Wijmenga, Cisca, Williams, O Dale, Bentley, Amy R, Hofman, Albert, Laurie, Cathy C, Lumley, Thomas, Morrison, Alanna C, Joubert, Bonnie R, Rivadeneira, Fernando, Couper, David J, Kritchevsky, Stephen B, Liu, Yongmei, Wjst, Matthias, Wain, Louise V, Vonk, Judith M, Uitterlinden, André G, Rochat, Thierry, Rich, Stephen S, Psaty, Bruce M, O'Connor, George T, North, Kari E, Mirel, Daniel B, Meibohm, Bernd, Launer, Lenore J, Khaw, Kay-Tee, Hartikainen, Anna-Liisa, Hammond, Christopher J, Gläser, Sven, Marchini, Jonathan, Kraft, Peter, Wareham, Nicholas J, Völzke, Henry, Stricker, Bruno H C, Spector, Timothy D, Probst-Hensch, Nicole M, Jarvis, Deborah, Jarvelin, Marjo-Riitta, Heckbert, Susan R, Gudnason, Vilmundur, Boezen, H Marike, Barr, R Graham, Cassano, Patricia A, Strachan, David P, Fornage, Myriam, Hall, Ian P, Dupuis, Josée, Tobin, Martin D, and London, Stephanie J
- Abstract
Genome-wide association studies have identified numerous genetic loci for spirometic measures of pulmonary function, forced expiratory volume in one second (FEV1), and its ratio to forced vital capacity (FEV1/FVC). Given that cigarette smoking adversely affects pulmonary function, we conducted genome-wide joint meta-analyses (JMA) of single nucleotide polymorphism (SNP) and SNP-by-smoking (ever-smoking or pack-years) associations on FEV1 and FEV1/FVC across 19 studies (total N = 50,047). We identified three novel loci not previously associated with pulmonary function. SNPs in or near DNER (smallest PJMA = 5.00×10−11), HLA-DQB1 and HLA-DQA2 (smallest PJMA = 4.35×10−9), and KCNJ2 and SOX9 (smallest PJMA = 1.28×10−8) were associated with FEV1/FVC or FEV1 in meta-analysis models including SNP main effects, smoking main effects, and SNP-by-smoking (ever-smoking or pack-years) interaction. The HLA region has been widely implicated for autoimmune and lung phenotypes, unlike the other novel loci, which have not been widely implicated. We evaluated DNER, KCNJ2, and SOX9 and found them to be expressed in human lung tissue. DNER and SOX9 further showed evidence of differential expression in human airway epithelium in smokers compared to non-smokers. Our findings demonstrated that joint testing of SNP and SNP-by-environment interaction identified novel loci associated with complex traits that are missed when considering only the genetic main effects.
- Published
- 2012
- Full Text
- View/download PDF
11. Genome-Wide Joint Meta-Analysis of SNP and SNP-by-Smoking Interaction Identifies Novel Loci for Pulmonary Function
- Author
-
Hancock, Dana B., primary, Artigas, María Soler, additional, Gharib, Sina A., additional, Henry, Amanda, additional, Manichaikul, Ani, additional, Ramasamy, Adaikalavan, additional, Loth, Daan W., additional, Imboden, Medea, additional, Koch, Beate, additional, McArdle, Wendy L., additional, Smith, Albert V., additional, Smolonska, Joanna, additional, Sood, Akshay, additional, Tang, Wenbo, additional, Wilk, Jemma B., additional, Zhai, Guangju, additional, Zhao, Jing Hua, additional, Aschard, Hugues, additional, Burkart, Kristin M., additional, Curjuric, Ivan, additional, Eijgelsheim, Mark, additional, Elliott, Paul, additional, Gu, Xiangjun, additional, Harris, Tamara B., additional, Janson, Christer, additional, Homuth, Georg, additional, Hysi, Pirro G., additional, Liu, Jason Z., additional, Loehr, Laura R., additional, Lohman, Kurt, additional, Loos, Ruth J. F., additional, Manning, Alisa K., additional, Marciante, Kristin D., additional, Obeidat, Ma'en, additional, Postma, Dirkje S., additional, Aldrich, Melinda C., additional, Brusselle, Guy G., additional, Chen, Ting-hsu, additional, Eiriksdottir, Gudny, additional, Franceschini, Nora, additional, Heinrich, Joachim, additional, Rotter, Jerome I., additional, Wijmenga, Cisca, additional, Williams, O. Dale, additional, Bentley, Amy R., additional, Hofman, Albert, additional, Laurie, Cathy C., additional, Lumley, Thomas, additional, Morrison, Alanna C., additional, Joubert, Bonnie R., additional, Rivadeneira, Fernando, additional, Couper, David J., additional, Kritchevsky, Stephen B., additional, Liu, Yongmei, additional, Wjst, Matthias, additional, Wain, Louise V., additional, Vonk, Judith M., additional, Uitterlinden, André G., additional, Rochat, Thierry, additional, Rich, Stephen S., additional, Psaty, Bruce M., additional, O'Connor, George T., additional, North, Kari E., additional, Mirel, Daniel B., additional, Meibohm, Bernd, additional, Launer, Lenore J., additional, Khaw, Kay-Tee, additional, Hartikainen, Anna-Liisa, additional, Hammond, Christopher J., additional, Gläser, Sven, additional, Marchini, Jonathan, additional, Kraft, Peter, additional, Wareham, Nicholas J., additional, Völzke, Henry, additional, Stricker, Bruno H. C., additional, Spector, Timothy D., additional, Probst-Hensch, Nicole M., additional, Jarvis, Deborah, additional, Jarvelin, Marjo-Riitta, additional, Heckbert, Susan R., additional, Gudnason, Vilmundur, additional, Boezen, H. Marike, additional, Barr, R. Graham, additional, Cassano, Patricia A., additional, Strachan, David P., additional, Fornage, Myriam, additional, Hall, Ian P., additional, Dupuis, Josée, additional, Tobin, Martin D., additional, and London, Stephanie J., additional
- Published
- 2012
- Full Text
- View/download PDF
12. Meta-analysis and imputation refines the association of 15q25 with smoking quantity.
- Author
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Liu, Jason Z., Tozzi, Federica, Waterworth, Dawn M., Pillai, Sreekumar G., Muglia, Pierandrea, Middleton, Lefkos, Berrettini, Wade, Knouff, Christopher W., Xin Yuan, Waeber, Gérard, Vollenweider, Peter, Preisig, Martin, Wareham, Nicholas J., Jing Hua Zhao, Loos, Ruth J F., Barroso, Inês, Kay-Tee Khaw, Grundy, Scott, Barter, Philip, and Mahley, Robert
- Subjects
- *
LOCUS (Genetics) , *SMOKING , *TOBACCO use , *LUNG cancer & genetics , *CANCER genetics , *CANCER genes , *GENETICS ,RISK factors ,HEALTH of cigarette smokers - Abstract
Smoking is a leading global cause of disease and mortality. We established the Oxford-GlaxoSmithKline study (Ox-GSK) to perform a genome-wide meta-analysis of SNP association with smoking-related behavioral traits. Our final data set included 41,150 individuals drawn from 20 disease, population and control cohorts. Our analysis confirmed an effect on smoking quantity at a locus on 15q25 (P = 9.45 × 10−19) that includes CHRNA5, CHRNA3 and CHRNB4, three genes encoding neuronal nicotinic acetylcholine receptor subunits. We used data from the 1000 Genomes project to investigate the region using imputation, which allowed for analysis of virtually all common SNPs in the region and offered a fivefold increase in marker density over HapMap2 (ref. 2) as an imputation reference panel. Our fine-mapping approach identified a SNP showing the highest significance, rs55853698, located within the promoter region of CHRNA5. Conditional analysis also identified a secondary locus (rs6495308) in CHRNA3. [ABSTRACT FROM AUTHOR]
- Published
- 2010
- Full Text
- View/download PDF
13. Genome-Wide Joint Meta-Analysis of SNP and SNP-by-Smoking Interaction Identifies Novel Loci for Pulmonary Function
- Author
-
Hancock, Dana B., Artigas, Maria Soler, Gharib, Sina A., Henry, Amanda, Manichaikul, Ani, Ramasamy, Adaikalavan, Loth, Daan W., Imboden, Medea, Koch, Beate, McArdle, Wendy L., Smith, Albert V., Smolonska, Joanna, Sood, Akshay, Tang, Wenbo, Wilk, Jemma B., Zhai, Guangju, Zhao, Jing Hua, Aschard, Hugues, Burkart, Kristin Marie, Curjuric, Ivan, Eijgelsheim, Mark, Elliott, Paul, Gu, Xiangjun, Harris, Tamara B., Janson, Christer, Homuth, Georg, Hysi, Pirro G., Liu, Jason Z., Loehr, Laura R., Lohman, Kurt, Loos, Ruth J. F., Manning, Alisa K., Marciante, Kristin D., Obeidat, Ma’en, Postma, Dirkje S., Aldrich, Melinda C., Brusselle, Guy G., Chen, Ting-Hsu, Eiriksdottir, Gudny, Franceschini, Nora, Heinrich, Joachim, Rotter, Jerome I., Wijmenga, Cisca, Williams, O. Dale, Bentley, Amy R., Hofman, Albert, Laurie, Cathy C., Lumley, Thomas, Morrison, Alanna C., Joubert, Bonnie R., Rivadeneira, Fernando, Couper, David J., Kritchevsky, Stephen B., Liu, Yongmei, Wjst, Matthias, Wain, Louise V., Vonk, Judith M., Uitterlinden, Andre G., Rochat, Thierry, Rich, Stephen S., Psaty, Bruce M., O’Connor, George T., North, Kari E., Mirel, Daniel B., Meibohm, Bernd, Launer, Lenore J., Khaw, Kay-Tee, Hartikainen, Anna-Liisa, Hammond, Christopher J., Glaser, Sven, Marchini, Jonathan, Kraft, Peter, Wareham, Nicholas J., Volzke, Henry, Stricker, Bruno H. C., Spector, Timothy D., Probst-Hensch, Nicole M., Jarvis, Deborah, Jarvelin, Marjo-Riitta, Heckbert, Susan R., Gudnason, Vilmundur, Boezen, H. Marike, Barr, R. Graham, Cassano, Patricia A., Strachan, David P., Fornage, Myriam, Hall, Ian P., Dupuis, Josee, Tobin, Martin D., and London, Stephanie J.
- Subjects
Meta-analysis ,Smoking ,Single nucleotide polymorphisms ,respiratory system ,Lungs ,respiratory tract diseases ,3. Good health - Abstract
Genome-wide association studies have identified numerous genetic loci for spirometic measures of pulmonary function, forced expiratory volume in one second (FEV1), and its ratio to forced vital capacity (FEV1/FVC). Given that cigarette smoking adversely affects pulmonary function, we conducted genome-wide joint meta-analyses (JMA) of single nucleotide polymorphism (SNP) and SNP-by-smoking (ever-smoking or pack-years) associations on FEV1 and FEV1/FVC across 19 studies (total N = 50,047). We identified three novel loci not previously associated with pulmonary function. SNPs in or near DNER (smallest PJMA = 5.00×10−11), HLA-DQB1 and HLA-DQA2 (smallest PJMA = 4.35×10−9), and KCNJ2 and SOX9 (smallest PJMA = 1.28×10−8) were associated with FEV1/FVC or FEV1 in meta-analysis models including SNP main effects, smoking main effects, and SNP-by-smoking (ever-smoking or pack-years) interaction. The HLA region has been widely implicated for autoimmune and lung phenotypes, unlike the other novel loci, which have not been widely implicated. We evaluated DNER, KCNJ2, and SOX9 and found them to be expressed in human lung tissue. DNER and SOX9 further showed evidence of differential expression in human airway epithelium in smokers compared to non-smokers. Our findings demonstrated that joint testing of SNP and SNP-by-environment interaction identified novel loci associated with complex traits that are missed when considering only the genetic main effects.
14. Layer-specific, retinotopically-diffuse modulation in human visual cortex in response to viewing emotionally expressive faces.
- Author
-
Liu, Tina T., Fu, Jason Z, Chai, Yuhui, Japee, Shruti, Chen, Gang, Ungerleider, Leslie G., and Merriam, Elisha P.
- Subjects
VISUAL cortex ,AMYGDALOID body ,FACE ,SELF-expression ,FUNCTIONAL magnetic resonance imaging ,FACIAL expression ,JUDGMENT (Psychology) - Abstract
Viewing faces that are perceived as emotionally expressive evokes enhanced neural responses in multiple brain regions, a phenomenon thought to depend critically on the amygdala. This emotion-related modulation is evident even in primary visual cortex (V1), providing a potential neural substrate by which emotionally salient stimuli can affect perception. How does emotional valence information, computed in the amygdala, reach V1? Here we use high-resolution functional MRI to investigate the layer profile and retinotopic distribution of neural activity specific to emotional facial expressions. Across three experiments, human participants viewed centrally presented face stimuli varying in emotional expression and performed a gender judgment task. We found that facial valence sensitivity was evident only in superficial cortical layers and was not restricted to the retinotopic location of the stimuli, consistent with diffuse feedback-like projections from the amygdala. Together, our results provide a feedback mechanism by which the amygdala directly modulates activity at the earliest stage of visual processing. Face stimuli that are perceived as emotionally expressive rather than neutral are associated with specific neural responses in V1. Here the authors show that valence information perceived from facial expressions is computed in the amygdala and fed back to V1 via direct anatomical projections. [ABSTRACT FROM AUTHOR]
- Published
- 2022
- Full Text
- View/download PDF
15. Truck suspension incorporating inerters to minimise road damage.
- Author
-
Liu, Xiaofu, Jiang, Jason Z, Harrison, Andrew, and Na, Xiaoxiang
- Subjects
NOBLE gases ,LEAF springs ,REDUCTION potential ,ROADS - Abstract
Road damage caused by heavy vehicles is a serious problem experienced worldwide. This paper investigates the potential for reduction in road damage by incorporating the inerter element into truck suspension systems. Initially, quarter-car, pitch-plane and roll-plane models with two low-complexity inerter-based linear suspension layouts are investigated in the frequency domain. Reductions of the J
95 road damage index for each model are identified against conventional parallel spring–damper truck suspension layouts. It is also shown that the proposed suspensions are capable of enhancing the roll stability while keeping the road damage at a given level. Subsequently, the nonlinear relationship between force and displacement as manifested by leaf springs is incorporated into the pitch-plane and roll-plane time-domain models. These confirm the potential advantage of inerter-based suspension layouts for road damage reduction. [ABSTRACT FROM AUTHOR]- Published
- 2020
- Full Text
- View/download PDF
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