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2. Multicenter Assessment of Augmented Reality Registration Methods for Image-guided Interventions

Author

Li, Ningcheng, Wakim, Jonathan, Koethe, Yilun, Huber, Timothy, Gade, Terence, Hunt, Stephen, and Park, Brian

Subjects
Physics - Medical Physics, Computer Science - Computer Vision and Pattern Recognition, Computer Science - Human-Computer Interaction
Abstract

Purpose: To evaluate manual and automatic registration times as well as accuracy with augmented reality during alignment of a holographic 3-dimensional (3D) model onto the real-world environment. Method: 18 participants in various stages of clinical training across two academic centers registered a 3D CT phantom model onto a CT grid using the HoloLens 2 augmented reality headset 3 consecutive times. Registration times and accuracy were compared among different registration methods (hand gesture, Xbox controller, and automatic registration), levels of clinical experience, and consecutive attempts. Registration times were also compared with prior HoloLens 1 data. Results: Mean aggregate manual registration times were 27.7, 24.3, and 72.8 seconds for one-handed gesture, two-handed gesture, and Xbox controller, respectively; mean automatic registration time was 5.3s (ANOVA p<0.0001). No significant difference in registration times was found among attendings, residents and fellows, and medical students (p>0.05). Significant improvements in registration times were detected across consecutive attempts using hand gestures (p<0.01). Compared with previously reported HoloLens 1 experience, hand gesture registration times were 81.7% faster (p<0.05). Registration accuracies were not significantly different across manual registration methods, measuring at 5.9, 9.5, and 8.6 mm with one-handed gesture, two-handed gesture, and Xbox controller, respectively (p>0.05). Conclusions: Manual registration times decreased significantly with updated hand gesture maneuvers on HoloLens 2 versus HoloLens 1, approaching the registration times of automatic registration and outperforming Xbox controller mediated registration. These results will encourage wider clinical integration of HoloLens 2 in procedural medical care., Comment: 16 pages, 5 figures (plus 1 supplemental figure), and 1 table

Published
2020

3. A Modern Non-SQL Approach to Radiology-Centric Search Engine Design with Clinical Validation

Author

Li, Ningcheng, Maresh, Guy, Cretcher, Maxwell, Farsad, Khashayar, Al-Hakim, Ramsey, Kaufman, John, and Gichoya, Judy

Subjects
Computer Science - Information Retrieval, Computer Science - Computers and Society
Abstract

Healthcare data is increasing in size at an unprecedented speed with much attention on big data analysis and Artificial Intelligence application for quality assurance, clinical training, severity triaging, and decision support. Radiology is well-suited for innovation given its intrinsically paired linguistic and visual data. Previous attempts to unlock this information goldmine were encumbered by heterogeneity of human language, proprietary search algorithms, and lack of medicine-specific search performance matrices. We present a de novo process of developing a document-based, secure, efficient, and accurate search engine in the context of Radiology. We assess our implementation of the search engine with comparison to pre-existing manually collected clinical databases used previously for clinical research projects in addition to computational performance benchmarks and survey feedback. By leveraging efficient database architecture, search capability, and clinical thinking, radiologists are at the forefront of harnessing the power of healthcare data.

Published
2020

8. Safety and Effectiveness of Portal Vein Embolization after Hepatic Arterial Infusion Therapy.

Author

Li, Ningcheng, Schwantes, Issac R., Mayo, Skye C., Park, Brian, and Koethe, Yilun

Abstract

Portal vein embolization (PVE) is a tool potentially useful for inducing future liver remnant (FLR) hypertrophy in patients with advanced hepatic malignancies who are at high risk of hepatic insufficiency if treated with surgical resection. However, the safety and effectiveness of PVE in the context of patients who have undergone hepatic arterial infusion (HAI) are unknown. This retrospective, single-center study identified 9 patients who underwent PVE after HAI between January 2015 and December 2022. There were no major adverse events, including biliary injury or high-grade liver failure. Analysis showed an increase in standardized FLR from 21.1% (SEM ± 2.4) to 34.8% (SEM ± 2.1) over 9.8 weeks (SEM ± 1.2), with a mean kinetic growth rate of 1.9% (interquartile range, 0.9%–2.4%). Patients who have undergone HAI therapy should not be excluded from consideration of PVE as part of their operative clearance strategy. [Display omitted] [ABSTRACT FROM AUTHOR]

Published
2024
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18. Endovascular Venous Stenosis and Thrombosis Large Animal Model: Angiographic, Histological, and Biomechanical Characterizations

Author

Li, Ningcheng, primary, Ferracane, Jack, additional, Andeen, Nicole, additional, Lewis, Steven, additional, Woltjer, Randy, additional, Rugonyi, Sandra, additional, Jahangiri, Younes, additional, Uchida, Barry, additional, Farsad, Khashayar, additional, Kaufman, John A., additional, and Al-Hakim, Ramsey A., additional

Published
2021
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27. Material Suitability Testing for Nonmedical Grade Community Face Masks to Decrease Viral Transmission During a Pandemic.

Author

Varallyay, Csanad, Li, Ningcheng, Case, Brendan, and Wolf, Bryan

Subjects
MEDICAL masks, COVID-19, VIRAL transmission, NONWOVEN textiles, INFECTION control
Abstract

Objectives: Cloth face covering has been recommended by the Centers for Disease Control and Prevention to decrease community viral transmission. This study aims to determine the filtration efficiency and airflow resistance of common household materials available for homemade mask production by comparing numbers of fabrics, various layers, and manipulation. Methods: Common household woven, knitted, and nonwoven fabrics were tested for filtration efficiency using a fit testing setup and airflow resistance with pressure gauge setup. Three different levels of layering (1, 2, and 4) were tested. Some fabric material was further tested after washing and drying. Filtration performance, the area under the fitted curve comparing airflow resistance and filtration efficiency, was calculated for each fabric material and compared. Results: Layering increased filtration efficiency and airflow resistance (P < 0.0001 and P < 0.01, respectively). Polyester felt demonstrated the highest filtration performance index (P < 0.0001), higher than all tested 100% cotton materials (all P < 0.05) as well as surgical masks (P < 0.05). Washing plus drying did not alter filtration performance significantly (P > 0.05). Conclusions: A filtration performance of common household fabrics were compared. Homemade mask designers and producers will have improved data to better balance effectiveness, availability, and comfort with the goal of decreasing community viral transmission. [ABSTRACT FROM AUTHOR]

Published
2021
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32. STAT4 and T-bet control follicular helper T cell development in viral infections

Author

Weinstein, Jason S., Laidlaw, Brian J., Lu, Yisi, Wang, Jessica K., Schulz, Vincent P., Li, Ningcheng, Herman, Edward I., Kaech, Susan M., Gallagher, Patrick G., and Craft, Joe

Abstract

Follicular helper T (Tfh) cells promote germinal center (GC) B cell survival and proliferation and guide their differentiation and immunoglobulin isotype switching by delivering contact-dependent and soluble factors, including IL-21, IL-4, IL-9, and IFN-γ. IL-21 and IFN-γ are coexpressed by Tfh cells during viral infections, but transcriptional regulation of these cytokines is not completely understood. In this study, we show that the T helper type 1 cell (Th1 cell) transcriptional regulators T-bet and STAT4 are coexpressed with Bcl6 in Tfh cells after acute viral infection, with a temporal decline in T-bet in the waning response. T-bet is important for Tfh cell production of IFN-γ, but not IL-21, and for a robust GC reaction. STAT4, phosphorylated in Tfh cells upon infection, is required for expression of T-bet and Bcl6 and for IFN-γ and IL-21. These data indicate that T-bet is expressed with Bcl6 in Tfh cells and is required alongside STAT4 to coordinate Tfh cell IL-21 and IFN-γ production and for promotion of the GC response after acute viral challenge.

Published
2018
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