Search

Your search keyword '"Leys, Mathias"' showing total 22 results
Start Over "Leys, Mathias"
22 results on '"Leys, Mathias"'

2. Non-typeable Haemophilus influenzae–Moraxella catarrhalis vaccine for the prevention of exacerbations in chronic obstructive pulmonary disease: a multicentre, randomised, placebo-controlled, observer-blinded, proof-of-concept, phase 2b trial

Author

Brusselle, Guy, Corhay, Jean-Louis, Janssens, Eduard, Janssens, Wim, Leys, Mathias, Ferguson, Murdo, Fitzgerald, Mark, Maltais, François, Mayers, Irvin, McNeil, Shelly, Pek, Bonavuth, Bourdin, Arnaud, Boyer, Laurent, Couturaud, Francis, Dussart, Luc, Andreas, Stefan, Illies, Gabriele, Eich, Andreas, Ludwig-Sengpiel, Andrea, Watz, Henrik, Blasi, Francesco, Centanni, Stefano, Papi, Alberto, Pomari, Carlo, Echave-Sustaeta, José Maria, Llorca Martínez, Eleuterio, Narejos Pérez, Silvia, Pascual-Guardia, Sergi, Pérez Vera, Mercè, Puente-Maestu, Luis, Terns Riera, Manuel, Anderson, William, Choudhury, Gourab, De-Soyza, Anthony, Saralaya, Dinesh, Wilkinson, Tom MA, Boscia III, Joseph, Chinsky, Kenneth, Dunn, Leonard, Erb, David, Fogarty, Charles, Downey, Herman Jackson, Kerwin, Edward, Kunz, Craig, Poling, Terry, Sellman, Richard, Sigal, Barry, Southard, John, Spangenthal, Selwyn, Tannous, Ziad, Testa, Marco, Casula, Daniela, Di Maro, Gennaro, Lattanzi, Maria, Moraschini, Luca, Schoonbroodt, Sonia, Tasciotti, Annaelisa, Arora, Ashwani K, and Wilkinson, Tom M A

Published
2022
Full Text
View/download PDF

5. Early high antibody titre convalescent plasma for hospitalised COVID-19 patients: DAWn-plasma

Author

Devos, Timothy, Van Thillo, Quentin, Compernolle, Veerle, Najdovski, Tomé, Romano, Marta, Dauby, Nicolas, Jadot, Laurent, Leys, Mathias, Maillart, Evelyne, Loof, Sarah, Seyler, Lucie, Moonen, Martial, Moutschen, Michel, Van Regenmortel, Niels, Ariën, Kevin K., Barbezange, Cyril, Betrains, Albrecht, Garigliany, Mutien, Engelen, Matthias M., Gyselinck, Iwein, Maes, Piet, Schauwvlieghe, Alexander, Liesenborghs, Laurens, Belmans, Ann, Verhamme, Peter, Meyfroidt, Geert, DAWn-plasma investigators, [ missing ], Gyselinck, Iwein/0000-0002-4068-7228, Barbezange, Cyril/0000-0001-9606-2983, Dauby, Nicolas/0000-0002-7697-6849, Liesenborghs, Laurens/0000-0001-5616-8548, Devos , Timothy, Van Thillo, Quentin, Compernolle, Veerle, Najdovski, Tome, Romano, Marta, Dauby, Nicolas, Jadot, Laurent, Leys, Mathias, Maillart, Evelyne, Loof, Sarah, Seyler , Lucie, Moonen , Martial, Moutschen, Michel, Van Regenmortel, Niels, Arien, Kevin K., Barbezange, Cyril, Betrains, Albrecht, Garigliany, Mutien, Engelen, Matthias M., Gyselinck, Iwein, Maes, Piet, Schauwvlieghe, Alexander, Liesenborghs, Laurens, Belmans, Ann, Verhamme, Peter, Meyfroidt, Geert, DAWn-plasma investigators, Faculty of Sciences and Bioengineering Sciences, Internal Medicine, Internal Medicine Specializations, and Clinical sciences

Subjects
Pulmonary and Respiratory Medicine, Adult, medicine.medical_specialty, Convalescent plasma, Coronavirus disease 2019 (COVID-19), medicine.medical_treatment, Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), Antibodies, Viral, Antibodies, Viral/blood, Internal medicine, medicine, Medicine and Health Sciences, Humans, Prospective Studies, Antibodies, Neutralizing/blood, Adverse effect, Mechanical ventilation, biology, business.industry, Immunization, Passive, COVID-19, Odds ratio, Sciences bio-médicales et agricoles, Antibodies, Neutralizing, Clinical trial, Hospitalization, Treatment Outcome, DAWn-plasma investigators, biology.protein, Human medicine, Antibody, business, COVID-19/therapy
Abstract

Background Several randomised clinical trials have studied convalescent plasma (CP) for COVID-19 using different protocols, with different SARS-CoV-2 neutralising-antibody-titres, at different time-points and severities of illness. Methods In the prospective multicentre DAWN-plasma trial, adult patients hospitalised with COVID-19 were randomised to 4 units of open-label convalescent plasma combined with standard of care (intervention group) or standard of care alone (control group). Plasma from donors with neutralising-antibody-titres (NT50) ≥1/320 was the product of choice for the study. Results Between May 2nd, 2020 and January 26th, 2021, 320 patients were randomised to convalescent plasma and 163 patients to the control group according to a 2:1 allocation scheme. A median volume of 884 mL convalescent plasma (IQR 806–906 mL) was administered, and 80.68% of the units came from donors with neutralising-antibody-titres (NT50) ≥1/320. Median time from onset of symptoms to randomisation was 7 days. The proportion of patients alive and free of mechanical ventilation on Day 15 was not different between both groups (convalescent plasma: 83.74% (n=267) versus control: 84.05% (n=137) – Odds ratio 0.99 (0.59–1.66) – p-value=0.9772). The intervention did not change the natural course of antibody titres. The number of serious or severe adverse events was similar in both study arms, and transfusion-related side effects were reported in 19/320 patients in the intervention group (5.94%). Conclusions Transfusion of 4 units of convalescent plasma with high neutralising-antibody-titres early in hospitalised COVID-19 patients did not result in a significant improvement of the clinical status, or a reduced mortality., info:eu-repo/semantics/published

Published
2022

6. How to Choose the Right Inhaler Using a Patient-Centric Approach?

Author

UCL - SSS/IRSS - Institut de recherche santé et société, Cataldo, Didier, Hanon, Shane, Peché, Rudi V., Schuermans, Daniel J., Degryse, Jean-Marie, De Wulf, Isabelle A., Elinck, Karin, Leys, Mathias H., Rummens, Peter L., Derom, Eric, UCL - SSS/IRSS - Institut de recherche santé et société, Cataldo, Didier, Hanon, Shane, Peché, Rudi V., Schuermans, Daniel J., Degryse, Jean-Marie, De Wulf, Isabelle A., Elinck, Karin, Leys, Mathias H., Rummens, Peter L., and Derom, Eric

Abstract

There are many different inhaler devices and medications on the market for the treatment of asthma and chronic obstructive pulmonary disease, with over 230 drug-delivery system combinations available. However, despite the abundance of effective treatment options, the achieved disease control in clinical practice often remains unsatisfactory. In this context, a key determining factor is the match or mismatch of an inhalation device with the characteristics or needs of an individual patient. Indeed, to date, no ideal device exists that fits all patients, and a personalized approach needs to be considered. Several useful choice-guiding algorithms have been developed in the recent years to improve inhaler–patient matching, but a comprehensive tool that translates the multifactorial complexity of inhalation therapy into a user-friendly algorithm is still lacking. To address this, a multidisciplinary expert panel has developed an evidence-based practical treatment tool that allows a straightforward way Supplementary Information The online version of choosing the right inhaler for each patient.

Published
2022

7. Non-typeable Haemophilus influenzae–Moraxella catarrhalis vaccine for the prevention of exacerbations in chronic obstructive pulmonary disease: a multicentre, randomised, placebo-controlled, observer-blinded, proof-of-concept, phase 2b trial

Author

Andreas, Stefan, primary, Testa, Marco, additional, Boyer, Laurent, additional, Brusselle, Guy, additional, Janssens, Wim, additional, Kerwin, Edward, additional, Papi, Alberto, additional, Pek, Bonavuth, additional, Puente-Maestu, Luis, additional, Saralaya, Dinesh, additional, Watz, Henrik, additional, Wilkinson, Tom M A, additional, Casula, Daniela, additional, Di Maro, Gennaro, additional, Lattanzi, Maria, additional, Moraschini, Luca, additional, Schoonbroodt, Sonia, additional, Tasciotti, Annaelisa, additional, Arora, Ashwani K, additional, Maltais, François, additional, Corhay, Jean-Louis, additional, Janssens, Eduard, additional, Leys, Mathias, additional, Ferguson, Murdo, additional, Fitzgerald, Mark, additional, Mayers, Irvin, additional, McNeil, Shelly, additional, Bourdin, Arnaud, additional, Couturaud, Francis, additional, Dussart, Luc, additional, Andreas, Stefan, additional, Illies, Gabriele, additional, Eich, Andreas, additional, Ludwig-Sengpiel, Andrea, additional, Blasi, Francesco, additional, Centanni, Stefano, additional, Pomari, Carlo, additional, Echave-Sustaeta, José Maria, additional, Llorca Martínez, Eleuterio, additional, Narejos Pérez, Silvia, additional, Pascual-Guardia, Sergi, additional, Pérez Vera, Mercè, additional, Terns Riera, Manuel, additional, Anderson, William, additional, Choudhury, Gourab, additional, De-Soyza, Anthony, additional, Wilkinson, Tom MA, additional, Boscia III, Joseph, additional, Chinsky, Kenneth, additional, Dunn, Leonard, additional, Erb, David, additional, Fogarty, Charles, additional, Downey, Herman Jackson, additional, Kunz, Craig, additional, Poling, Terry, additional, Sellman, Richard, additional, Sigal, Barry, additional, Southard, John, additional, Spangenthal, Selwyn, additional, and Tannous, Ziad, additional

Published
2022
Full Text
View/download PDF

11. Early high antibody titre convalescent plasma for hospitalised COVID-19 patients: DAWn-plasma

Author

Devos, Timothy, primary, Van Thillo, Quentin, additional, Compernolle, Veerle, additional, Najdovski, Tomé, additional, Romano, Marta, additional, Dauby, Nicolas, additional, Jadot, Laurent, additional, Leys, Mathias, additional, Maillart, Evelyne, additional, Loof, Sarah, additional, Seyler, Lucie, additional, Moonen, Martial, additional, Moutschen, Michel, additional, Van Regenmortel, Niels, additional, Ariën, Kevin K., additional, Barbezange, Cyril, additional, Betrains, Albrecht, additional, Garigliany, Mutien, additional, Engelen, Matthias M., additional, Gyselinck, Iwein, additional, Maes, Piet, additional, Schauwvlieghe, Alexander, additional, Liesenborghs, Laurens, additional, Belmans, Ann, additional, Verhamme, Peter, additional, and Meyfroidt, Geert, additional

Published
2021
Full Text
View/download PDF

13. Early high antibody-titre convalescent plasma for hospitalised COVID-19 patients: DAWn-plasma

Author

Devos, Timothy, Van Thillo, Quentin, Compernolle, Veerle, Najdovski, Tome, Romano, Márta, Dauby, Nicolas, Jadot, Laurent, Leys, Mathias, Maillart, Evelyne, Loof, Sarah, Seyler, Lucie, Moonen, Martial, Moutschen, Michel, Van Regenmortel, Niels, Ariën, Kevin K., Barbezange, Cyril, Betrains, Albrecht, Garigliany, Mutien, Engelen, Matthias, Gyselinck, Iwein, Maes, Piet, Schauwvlieghe, Alexander, Liesenborghs, Laurens, Belmans, Ann, Verhamme, Peter, Meyfroidt, Geert, Devos, Timothy, Van Thillo, Quentin, Compernolle, Veerle, Najdovski, Tome, Romano, Márta, Dauby, Nicolas, Jadot, Laurent, Leys, Mathias, Maillart, Evelyne, Loof, Sarah, Seyler, Lucie, Moonen, Martial, Moutschen, Michel, Van Regenmortel, Niels, Ariën, Kevin K., Barbezange, Cyril, Betrains, Albrecht, Garigliany, Mutien, Engelen, Matthias, Gyselinck, Iwein, Maes, Piet, Schauwvlieghe, Alexander, Liesenborghs, Laurens, Belmans, Ann, Verhamme, Peter, and Meyfroidt, Geert

Abstract

Background Several randomised clinical trials have studied convalescent plasma (CP) for COVID-19 using different protocols, with different SARS-CoV-2 neutralising-antibody-titres, at different time-points and severities of illness. Methods In the prospective multicentre DAWN-plasma trial, adult patients hospitalised with COVID-19 were randomised to 4 units of open-label convalescent plasma combined with standard of care (intervention group) or standard of care alone (control group). Plasma from donors with neutralising-antibody-titres (NT50) ≥1/320 was the product of choice for the study. Results Between May 2nd, 2020 and January 26th, 2021, 320 patients were randomised to convalescent plasma and 163 patients to the control group according to a 2:1 allocation scheme. A median volume of 884 mL convalescent plasma (IQR 806–906 mL) was administered, and 80.68% of the units came from donors with neutralising-antibody-titres (NT50) ≥1/320. Median time from onset of symptoms to randomisation was 7 days. The proportion of patients alive and free of mechanical ventilation on Day 15 was not different between both groups (convalescent plasma: 83.74% (n=267) versus control: 84.05% (n=137) – Odds ratio 0.99 (0.59–1.66) – p-value=0.9772). The intervention did not change the natural course of antibody titres. The number of serious or severe adverse events was similar in both study arms, and transfusion-related side effects were reported in 19/320 patients in the intervention group (5.94%). Conclusions Transfusion of 4 units of convalescent plasma with high neutralising-antibody-titres early in hospitalised COVID-19 patients did not result in a significant improvement of the clinical status, or a reduced mortality., SCOPUS: ar.j, info:eu-repo/semantics/published

Published
2021

14. Non-typeable Haemophilus influenzae–Moraxella catarrhalisvaccine for the prevention of exacerbations in chronic obstructive pulmonary disease: a multicentre, randomised, placebo-controlled, observer-blinded, proof-of-concept, phase 2b trial

Author

Andreas, Stefan, Testa, Marco, Boyer, Laurent, Brusselle, Guy, Janssens, Wim, Kerwin, Edward, Papi, Alberto, Pek, Bonavuth, Puente-Maestu, Luis, Saralaya, Dinesh, Watz, Henrik, Wilkinson, Tom M A, Casula, Daniela, Di Maro, Gennaro, Lattanzi, Maria, Moraschini, Luca, Schoonbroodt, Sonia, Tasciotti, Annaelisa, Arora, Ashwani K, Maltais, François, Brusselle, Guy, Corhay, Jean-Louis, Janssens, Eduard, Janssens, Wim, Leys, Mathias, Ferguson, Murdo, Fitzgerald, Mark, Maltais, François, Mayers, Irvin, McNeil, Shelly, Pek, Bonavuth, Bourdin, Arnaud, Boyer, Laurent, Couturaud, Francis, Dussart, Luc, Andreas, Stefan, Illies, Gabriele, Eich, Andreas, Ludwig-Sengpiel, Andrea, Watz, Henrik, Blasi, Francesco, Centanni, Stefano, Papi, Alberto, Pomari, Carlo, Echave-Sustaeta, José Maria, Llorca Martínez, Eleuterio, Narejos Pérez, Silvia, Pascual-Guardia, Sergi, Pérez Vera, Mercè, Puente-Maestu, Luis, Terns Riera, Manuel, Anderson, William, Choudhury, Gourab, De-Soyza, Anthony, Saralaya, Dinesh, Wilkinson, Tom MA, Boscia III, Joseph, Chinsky, Kenneth, Dunn, Leonard, Erb, David, Fogarty, Charles, Downey, Herman Jackson, Kerwin, Edward, Kunz, Craig, Poling, Terry, Sellman, Richard, Sigal, Barry, Southard, John, Spangenthal, Selwyn, Tannous, Ziad, Testa, Marco, Casula, Daniela, Di Maro, Gennaro, Lattanzi, Maria, Moraschini, Luca, Schoonbroodt, Sonia, Tasciotti, Annaelisa, and Arora, Ashwani K

Abstract

Acute exacerbations of chronic obstructive pulmonary disease (AECOPD) are associated with changes in the sputum microbiome, including an increased prevalence of pathogenic bacteria. Vaccination against the most frequent bacteria identified in AECOPD might reduce exacerbation frequency. We assessed the efficacy, safety, and immunogenicity of a candidate vaccine containing surface proteins from non-typeable Haemophilus influenzae(NTHi) and Moraxella catarrhalis(Mcat) in patients with COPD.

Published
2022
Full Text
View/download PDF

18. Uveitis as a window to diagnosis of sarcoidosis – case report and review of the literature

Author

Dhont, Sebastiaan, Leys, Mathias, De Sutter, Edward, Alaerts, Herwig, and Van Moerkercke, Wouter

Abstract

ABSTRACTSarcoidosis is a multisystem disease of unclear etiology with a variable clinical profile characterized by the presence of non-caseating granuloma in involved organs. The diagnosis is often challenging and based on clinical, radiological and anatomopathological data. Sarcoidosis can be benign and self-limiting, but some cases may follow a chronic, progressive course and result in severe morbidity. The disease has a predilection for the lungs and thoracic lymph nodes but can involve nearly any part of the body, possible more commonly in areas with contact to the external environment, such as the eyes and the skin. This paper is based on a case in which a recurrent uveitis led to the diagnosis of an underlying sarcoidosis.

Published
2020
Full Text
View/download PDF

19. Hypocalcemia after Denosumab in a Pulmonary Hypertension Patient Receiving Epoprostenol.

Author

De Muynck, Benedicte, Leys, Mathias, Cuypers, Joke, Vanderschueren, Dirk, Delcroix, Marion, and Belge, Catharina

Subjects
*DENOSUMAB, *DIARRHEA, *HYPERPARATHYROIDISM, *HYPOCALCEMIA, *MALABSORPTION syndromes, *MONOCLONAL antibodies, *OSTEOMALACIA, *OSTEOPOROSIS, *PROSTACYCLIN, *PULMONARY hypertension, *PARESTHESIA, *DIAGNOSIS
Abstract

We report the case of a 50-year-old woman with anorexigen-induced pulmonary arterial hypertension treated with epoprostenol, who presented with Trousseau’s sign, leading to the diagnosis of severe hypocalcemia for which substitution was started (initially orally, followed by intravenous substitution). After further analysis, we assume that epoprostenol-induced diarrhea caused malabsorption (as other reasons were excluded), leading to nutritional osteomalacia with secondary hyperparathyroidism. We discovered that even more severe hypocalcemia was induced by the treatment with the anti-osteoporotic drug denosumab, which was started after the diagnosis of osteoporosis on bone densitometry. In our opinion, clinicians have to be aware that in patients with malabsorption, antiresorptive therapy can induce dangerous and even life-threatening hypocalcemia, even in patients with normal renal function. [ABSTRACT FROM AUTHOR]

Published
2018
Full Text
View/download PDF

20. A 64-year-old woman with interstitial lung disease and positive antibodies against aminoacyl-transfer RNA synthetases in the absence of myositis: presentation of an anti-PL-12 positive antisynthetase syndrome

Author

Ghysen, Katrien and Leys, Mathias

Abstract

AbstractIntroductionThe antisynthetase syndrome is a rare autoimmune disease described by the presence of inflammatory myositis, interstitial lung disease and antibodies against aminoacyl-transfer RNA synthetases. Interstitial lung disease can be the only manifestation in the absence of an inflammatory myositis. Other clinical signs are Raynaud phenomenon, hyperkeratotic skin lesions, fever and inflammatory polyarthritis.Case presentationWe report the case of a 64-year old woman who complained of a dry cough, progressive dyspnea and arthralgia since 2 years, with no other systemic symptoms. High resolution computed tomography (HRCT) of the thorax showed the presence of bilateral ground glass opacities, reticular opacities and some traction bronchiectasis. Further biochemical testing revealed the presence of anti-PL12 antibodies.ManagementThe diagnosis of antisynthetase syndrome was made and the patient was treated with steroids and azathioprine with a good response.ConclusionThe search for antisynthetase antibodies should always be considered in patients with an interstitial lung disease without any other clinical symptoms or signs of an underlying connective tissue disease.

Published
2018
Full Text
View/download PDF

21. Encephalopathy and severe metabolic acidosis in a schizophrenic patient

Author

Van Moerkercke, Wouter, Leys, Mathias, and Meersseman, Philippe

Subjects
Encephalopathy -- Diagnosis, Encephalopathy -- Case studies, Acidosis -- Diagnosis, Acidosis -- Case studies, Schizophrenics -- Medical examination, Environmental issues, Health, Pharmaceuticals and cosmetics industries
Published
2010

22. Balloon Pulmonary Angioplasty as a Treatment in Chronic Thromboembolic Pulmonary Hypertension: Past, Present, and Future.

Author

Karyofyllis, Panagiotis, Demerouti, Eftychia, Papadopoulou, Varvara, Voudris, Vassilis, and Matsubara, Hiromi

Abstract

Purpose of review: Chronic thromboembolic pulmonary hypertension (CTEPH) is a major cause of precapillary pulmonary hypertension leading to right heart failure and death if left untreated. In addition to pulmonary endarterectomy, which is considered the standard of care, and specific drug therapy that is not however expected to offer relief from the mechanical component of the disease, the therapeutic options for CTEPH have expanded with the development of balloon pulmonary angioplasty (BPA). The purpose of this review is a better understanding and evaluation of BPA as a treatment option in CTEPH patients. Recent findings: With the evolution of BPA almost all over the world, more centers outside Japan, which remains the leader for the technique, presented their results confirming the efficacy, safety, and feasibility of this procedure as a complementary strategy in the treatment algorithm of CTEPH. Summary: Summarizing, more data from all over the world confirm that BPA is a challenging but potentially effective intervention for the treatment of inoperable CTEPH patients. However, there is a need for standardization of the technique, and furthermore, large, international, multicenter randomized controlled trials comparing BPA with the other treatment modalities of CTEPH are imperative. [ABSTRACT FROM AUTHOR]

Published
2020
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results