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Levi R. Bryant. Difference and Givenness: Deleuze's Transcendental Empiricism and the Ontology of Immanence. Evanston, IL: Northwestern UP, 2008. xii + 278 pp. Levi R. Bryant's object is to provide [...]

Production scheduling is a class of widely studied combinatorial optimization problems. Given the complexity of the most addressed production environments several solution procedures have been proposed. In recent years, operational researcher practitioners have been paying attention to solving production scheduling problems using constraint programming, and growing interest in this research domain has been evidenced. The aim of this study is to report a descriptive bibliometric analysis of applications of constraint programming in production scheduling problems. The scope of the study is limited to reviewing 170 scientific papers published between 1992 and 2023 from the Scopus and Web of Science databases. In our proposed research questions, we could address the main topics studied, the most studied performance measures, and the profile of the analyzed documents. Furthermore, we could identify the main gaps and present suggestions for future research.

In this paper, a variant of the open shop scheduling problem is considered in which the intermediate storage is forbidden among two adjacent production stages (zero buffer or machine blocking constraint). The performance measure is to minimise the maximal completion time of the jobs (makespan). Since this is an NP-hard problem, a two-stage constraint programming approach is proposed as a new exact method. Computational experiments were carried out on 222 literature problem instances in order to test the performance of the proposed algorithm. The relative deviation is adopted as the performance criteria. Computational results point to the ability of the proposed method to solve large-sized instances in comparison with the developed mixed-integer linear programming model and a simple constraint programming model, both with user cuts. In all set of instances, the proposed two-stage method performed better than benchmarking methods and integer programming models, with average relative deviation regarding objective values as lower as 12%. In addition, the results point to a competitive efficiency in computational times of the proposed method with less than 200 s in the most instances to obtain the optimal solution, in comparison to competitive metaheuristics from literature of the problem, for the tested test instances. [ABSTRACT FROM AUTHOR]

Perceiving that a partner is highly committed tends to benefit close relationships. However, there may be relational drawbacks to perceiving high commitment. In particular, given that high commitment may signal that a partner is unlikely to leave the relationship, perceiving that a partner is highly committed might lead people low in agreeableness to feel comfortable behaving more selfishly toward that partner. One correlational study consisting of a highly diverse sample of individuals (n = 307), one observational study of newlywed couples (n = 202), and one experiment with undergraduate couples (n = 252) examined whether the implications of perceived partner commitment for selfish behaviors depend on agreeableness. Results demonstrated that perceiving high commitment resulted in more selfish behavior among disagreeable participants (Studies 1–3), but less selfish behavior among agreeable participants (Studies 1 and 3). Together, these results suggest that signaling commitment to disagreeable partners may backfire in romantic relationships. [ABSTRACT FROM AUTHOR]

BACKGROUND: Firefighter health is of utmost importance both to first responders and the individuals they serve daily. The impact of shift schedule on firefighter health remains poorly understood. OBJECTIVE: The purpose of this study was to examine differences in health and performance outcomes in firefighters across two different shift schedules. METHODS: Firefighter (N = 1995) body composition, muscular strength, endurance, flexibility, and cardiorespiratory endurance were assessed and described. A Mann-Whitney U test was conducted to compare differences between shift schedules (48/96 and 4's and 6's). RESULTS: There was a statistically significant difference in BMI (U = 70115, z=–1.988, p =.047), BF% (U = 67341, z=–2.779, p =.005), and trunk flexion score (U = 81362, z = 1.979, p =.048) favoring the 48/96 shift schedule. CONCLUSION: Firefighters following a 48/96 shift schedule exhibited improved body composition and fitness performance in comparison to peers who followed a 4's and 6's shift schedule. Findings may guide regional firefighter scheduling to optimize health and performance. [ABSTRACT FROM AUTHOR]

Radiomics features (RFs) serve as quantitative metrics to characterize shape, density/intensity, and texture patterns in radiological images. Despite their promise, RFs exhibit reproducibility challenges across acquisition settings, thus limiting implementation into clinical practice. In this investigation, we evaluate the effects of different CT scanners and CT acquisition protocols (KV, mA, field-of-view, and reconstruction kernel settings) on RFs extracted from lumbar vertebrae of a cadaveric trunk. Employing univariate and multivariate Generalized Linear Models (GLM), we evaluated the impact of each acquisition parameter on RFs. Our findings indicate that variations in mA had negligible effects on RFs, while alterations in kV resulted in exponential changes in several RFs, notably First Order (94.4%), GLCM (87.5%), and NGTDM (100%). Moreover, we demonstrated that a tailored GLM model was superior to the ComBat algorithm in harmonizing CT images. GLM achieved R2 > 0.90 in 21 RFs (19.6%), contrasting ComBat's mean R2 above 0.90 in only 1 RF (0.9%). This pioneering study unveils the effects of CT acquisition parameters on bone RFs in cadaveric specimens, highlighting significant variations across parameters and scanner datasets. The proposed GLM model presents a robust solution for mitigating these differences, potentially advancing harmonization efforts in Radiomics-based studies across diverse CT protocols and vendors., (© 2024. The Author(s).)

Purpose: To evaluate the efficacy of US-guided vacuum-assisted biopsy (US-VAB) in radiologic-pathologic (rad-path) discordance in women with suspicious breast lesions., Methods: Two thousand three hundred and sixty patients with 2385 BI-RADS category 4 and 5 lesions underwent percutaneous US-guided CNB. Thirty-six lesions were classified as discordant benign and underwent second-line US-VAB. A 14-gauge needle was utilized for CNB and 10-gauge for US-VAB. Final pathology was the reference standard for women who underwent surgery, imaging follow-up in other cases. Rates of malignancy for US-VAB and subsequent surgery were evaluated. Lesions with upgrade and no upgrade to second-line VAB were compared in terms of patient's age, lesion type and characteristics, size and BI-RADS category. Positive predictive value (PPV), negative predictive value (NPV) for BI-RADS categories and diagnostic performance for second-line US-VAB were calculated. p value < 0.05 was considered statistically significant (t-test, Mann-Whitney, χ 2 )., Results: US-VAB identified 10 B2, 9 B3 and 17 B5 lesions with upgrade to malignancy of 47.2% (17/36). There were 8 invasive no special type, 7 ductal in situ, 1 invasive lobular carcinoma and 1 angiosarcoma, and their distribution among BI-RADS categories was: 2/2 in BI-RADS 5 (100%), 12/18 in BI-RADS 4C (67%) and 3/16 in BI-RADS 4B lesions (19%) (p = 0.006). Of the remaining 19 lesions, 6 underwent surgery and 2 were upgraded to ductal carcinoma in situ; 13 underwent radiological follow-up and one resulted malignant. False-negative rate for US-VAB was 15.8% (3/19) with final upgrade to malignancy of 55% (20/36). The univariate analysis revealed mass shape (p = 0.008) and BI-RADS categories (p = 0.006) to be associated with upgrade to malignancy. Sensitivity, specificity, PPV, NPV and accuracy for US-VAB were 85, 100, 100, 84 and 92%, respectively., Conclusions: US-VAB identified almost 50% of cancers missed by CNB, avoiding surgical biopsies and validating as an effective mini-invasive approach in rad-path discordance., (© 2024. Italian Society of Medical Radiology.)

Human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CM) are a cell model now widely used to investigate pathophysiological features of cardiac tissue. Given the invaluable contribution hiPSC-CM could make for studies on cardio-metabolic disorders by defining a postnatal metabolic phenotype, our work herein focused on monitoring the insulin response in CM derived from the hiPSC line UKBi015-B. Western blot analysis on total cell lysates obtained from hiPSC-CM showed increased phosphorylation of both AKT and AS160 following insulin treatment, but failed to highlight any changes in the expression dynamics of the glucose transporter GLUT4. By contrast, the Western blot analysis of membrane fractions, rather than total lysates, revealed insulin-induced plasma membrane translocation of GLUT4, which is known to also occur in postnatal CM. Thus, these findings suggest that hiPSC-derived CMs exhibit an insulin response reminiscent to that of adult CMs regarding intracellular signaling and GLUT4 translocation to the plasma membrane, representing a suitable cellular model in the cardio-metabolic research field. Moreover, our studies also demonstrate the relevance of analyzing membrane fractions rather than total lysates in order to monitor GLUT4 dynamics in response to metabolic regulators in hiPSC-CMs.

Background/Objectives: Inflammatory bowel diseases (IBDs) are chronic disorders that require close monitoring with imaging techniques such as magnetic resonance enterography (MRE). Standardization of radiological reports is crucial for the optimal management of IBD. We surveyed Italian radiologists regarding their experiences with MRE examinations and reporting for IBD. Methods: All members of the Italian Society of Medical and Interventional Radiology (SIRM) were invited to complete an anonymous questionnaire in April 2023. Comparison tests between variables were assessed using the χ 2 test or Fisher exact test according to the least frequency group. Significance level was set for p -value < 0.05. Results: A total of 253 radiologists responded to the survey. Around 70% of the respondents declared personal clinical experience with IBD. Great agreement with the items included and described for both disease activity (i.e., intestinal wall thickness, presence of mucosal ulcers, presence of edema, mucous enhancement) and complications was reported. One-third of the respondents regularly used a structured MRE report. Centers with a high number of IBD patients per year (>1000) mostly used 3 T scanners or both 1.5 T and 3 T scanners ( p < 0.001). The incorporation of scores of disease activity was associated with university and high-volume hospitals ( p < 0.001). Conclusions: This survey highlighted the current routine practice and experience of MRE reports of IBD patients among Italian radiologists. We found deficiencies in the use of radiological scores in MRE reports and attendance at IBD multidisciplinary meetings.

Objective: To quantify the distribution of cauda equina nerve roots in supine and upright positions using manual measurements and radiomics features both in normal subjects and in lumbar spinal canal stenosis (LSCS) patients., Methods: We retrospectively recruited patients who underwent weight-bearing MRI in supine and upright positions for back pain. 3D T2-weighted isotropic acquisition (3D-HYCE) sequences were used to develop a 3D convolutional neural network for identification and segmentation of lumbar vertebrae. Para-axial reformatted images perpendicular to the spinal canal and parallel to each vertebral endplate were automatically extracted. From each level, we computed the maximum antero-posterior (AP) and latero-lateral (LL) dispersion of nerve roots; further, radiomics features were extracted to quantify standardized metrics of nerve root distribution., Results: We included 16 patients with LSCS and 20 normal subjects. In normal subjects, nerve root AP dispersion significantly increased from supine to upright position (p < 0.001, L2-L5 levels), and radiomics features showed an increase in non-uniformity. In LSCS subjects, in the upright position AP dispersion of nerve roots and entropy-related features increased caudally to the stenosis level (p < 0.001) and decreased cranially (p < 0.001). Moreover, entropy-related radiomics features negatively correlated with pre-operative Pain Numerical Rating Scale. Comparison between normal subjects and LSCS patients showed a difference in AP dispersion and increase of variance cranially to the stenosis level (p < 0.001) in the upright position., Conclusions: Nerve root distribution inside the dural sac changed between supine and upright positions, and radiomics features were able to quantify the differences between normal and LSCS subjects., Clinical Relevance Statement: The distribution of cauda equina nerve roots and the redundant nerve root sign significantly varies between supine and upright positions in normal subjects and spinal canal stenosis patients, respectively. Radiomics features quantify nerve root dispersion and correlates with pain severity., Key Points: • Weight-bearing MRI depicts spatial distribution of the cauda equina in both supine and upright positions in normal subjects and spinal stenosis patients. • Radiomics features can quantify the effects of spinal stenosis on the dispersion of the cauda equina in the dural sac. • In the orthostatic position, dispersion of nerve roots is different in lumbar spinal stenosis patients compared to that in normal subjects; entropy-related features negatively correlated with pre-operative Pain Numerical Rating Scale., (© 2023. The Author(s), under exclusive licence to European Society of Radiology.)

Author(s): Levi R. Bryant Title (English): A World Is Ending Journal Reference: Identities: Journal for Politics, Gender and Culture Publisher: Institute of Social Sciences and Humanities - Skopje Page Range: 50-54 Page Count: 5 Citation (English): Levi R. Bryant, “A World Is Ending,” Identities: Journal for Politics, Gender and Culture, Vol. 17, No. 1 (Summer 2020): 50-54.