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2. Correction: Assessing real-world gait with digital technology? Validation, insights and recommendations from the Mobilise-D consortium

Author

Micó-Amigo, M. Encarna, Bonci, Tecla, Paraschiv-Ionescu, Anisoara, Ullrich, Martin, Kirk, Cameron, Soltani, Abolfazl, Küderle, Arne, Gazit, Eran, Salis, Francesca, Alcock, Lisa, Aminian, Kamiar, Becker, Clemens, Bertuletti, Stefano, Brown, Philip, Buckley, Ellen, Cantu, Alma, Carsin, Anne-Elie, Caruso, Marco, Caulfield, Brian, Cereatti, Andrea, Chiari, Lorenzo, D’Ascanio, Ilaria, Eskofier, Bjoern, Fernstad, Sara, Froehlich, Marcel, Garcia-Aymerich, Judith, Hansen, Clint, Hausdorff, Jeffrey M., Hiden, Hugo, Hume, Emily, Keogh, Alison, Kluge, Felix, Koch, Sarah, Maetzler, Walter, Megaritis, Dimitrios, Mueller, Arne, Niessen, Martijn, Palmerini, Luca, Schwickert, Lars, Scott, Kirsty, Sharrack, Basil, Sillén, Henrik, Singleton, David, Vereijken, Beatrix, Vogiatzis, Ioannis, Yarnall, Alison J., Rochester, Lynn, Mazzà, Claudia, and Del Din, Silvia

Published
2024
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3. Mobilise-D insights to estimate real-world walking speed in multiple conditions with a wearable device

Author

Kirk, Cameron, Küderle, Arne, Micó-Amigo, M. Encarna, Bonci, Tecla, Paraschiv-Ionescu, Anisoara, Ullrich, Martin, Soltani, Abolfazl, Gazit, Eran, Salis, Francesca, Alcock, Lisa, Aminian, Kamiar, Becker, Clemens, Bertuletti, Stefano, Brown, Philip, Buckley, Ellen, Cantu, Alma, Carsin, Anne-Elie, Caruso, Marco, Caulfield, Brian, Cereatti, Andrea, Chiari, Lorenzo, D’Ascanio, Ilaria, Garcia-Aymerich, Judith, Hansen, Clint, Hausdorff, Jeffrey M., Hiden, Hugo, Hume, Emily, Keogh, Alison, Kluge, Felix, Koch, Sarah, Maetzler, Walter, Megaritis, Dimitrios, Mueller, Arne, Niessen, Martijn, Palmerini, Luca, Schwickert, Lars, Scott, Kirsty, Sharrack, Basil, Sillén, Henrik, Singleton, David, Vereijken, Beatrix, Vogiatzis, Ioannis, Yarnall, Alison J., Rochester, Lynn, Mazzà, Claudia, Eskofier, Bjoern M., and Del Din, Silvia

Published
2024
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5. Assessing real-world gait with digital technology? Validation, insights and recommendations from the Mobilise-D consortium

Author

Micó-Amigo, M. Encarna, Bonci, Tecla, Paraschiv-Ionescu, Anisoara, Ullrich, Martin, Kirk, Cameron, Soltani, Abolfazl, Küderle, Arne, Gazit, Eran, Salis, Francesca, Alcock, Lisa, Aminian, Kamiar, Becker, Clemens, Bertuletti, Stefano, Brown, Philip, Buckley, Ellen, Cantu, Alma, Carsin, Anne-Elie, Caruso, Marco, Caulfield, Brian, Cereatti, Andrea, Chiari, Lorenzo, D’Ascanio, Ilaria, Eskofier, Bjoern, Fernstad, Sara, Froehlich, Marcel, Garcia-Aymerich, Judith, Hansen, Clint, Hausdorff, Jeffrey M., Hiden, Hugo, Hume, Emily, Keogh, Alison, Kluge, Felix, Koch, Sarah, Maetzler, Walter, Megaritis, Dimitrios, Mueller, Arne, Niessen, Martijn, Palmerini, Luca, Schwickert, Lars, Scott, Kirsty, Sharrack, Basil, Sillén, Henrik, Singleton, David, Vereijken, Beatrix, Vogiatzis, Ioannis, Yarnall, Alison J., Rochester, Lynn, Mazzà, Claudia, and Del Din, Silvia

Published
2023
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7. Design and validation of a multi-task, multi-context protocol for real-world gait simulation

Author

Scott, Kirsty, Bonci, Tecla, Salis, Francesca, Alcock, Lisa, Buckley, Ellen, Gazit, Eran, Hansen, Clint, Schwickert, Lars, Aminian, Kamiar, Bertuletti, Stefano, Caruso, Marco, Chiari, Lorenzo, Sharrack, Basil, Maetzler, Walter, Becker, Clemens, Hausdorff, Jeffrey M., Vogiatzis, Ioannis, Brown, Philip, Del Din, Silvia, Eskofier, Björn, Paraschiv-Ionescu, Anisoara, Keogh, Alison, Kirk, Cameron, Kluge, Felix, Micó-Amigo, Encarna M., Mueller, Arne, Neatrour, Isabel, Niessen, Martijn, Palmerini, Luca, Sillen, Henrik, Singleton, David, Ullrich, Martin, Vereijken, Beatrix, Froehlich, Marcel, Brittain, Gavin, Caulfield, Brian, Koch, Sarah, Carsin, Anne-Elie, Garcia-Aymerich, Judith, Kuederle, Arne, Yarnall, Alison, Rochester, Lynn, Cereatti, Andrea, and Mazzà, Claudia

Published
2022
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10. Are You in Pain? Predicting Pain and Stiffness from Wearable Sensor Activity Data

Author

Sett, Niladri, Mac Namee, Brian, Calvo, Francesc, Caulfield, Brian, Costello, John, Donnelly, Seamas C., Dorn, Jonas F., Jeay, Louis, Keogh, Alison, McManus, Killian, Mullan, Ronan H., O’Hare, Emer, Perraudin, Caroline G. M., Goos, Gerhard, Founding Editor, Hartmanis, Juris, Founding Editor, Bertino, Elisa, Editorial Board Member, Gao, Wen, Editorial Board Member, Steffen, Bernhard, Editorial Board Member, Woeginger, Gerhard, Editorial Board Member, Yung, Moti, Editorial Board Member, Bramer, Max, editor, and Petridis, Miltos, editor

Published
2019
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13. Walking on common ground: a cross-disciplinary scoping review on the clinical utility of digital mobility outcomes

Author

Polhemus, Ashley, Delgado-Ortiz, Laura, Brittain, Gavin, Chynkiamis, Nikolaos, Salis, Francesca, Gaßner, Heiko, Gross, Michaela, Kirk, Cameron, Rossanigo, Rachele, Taraldsen, Kristin, Balta, Diletta, Breuls, Sofie, Buttery, Sara, Cardenas, Gabriela, Endress, Christoph, Gugenhan, Julia, Keogh, Alison, Kluge, Felix, Koch, Sarah, Micó-Amigo, M. Encarna, Nerz, Corinna, Sieber, Chloé, Williams, Parris, Bergquist, Ronny, Bosch de Basea, Magda, Buckley, Ellen, Hansen, Clint, Mikolaizak, A. Stefanie, Schwickert, Lars, Scott, Kirsty, Stallforth, Sabine, van Uem, Janet, Vereijken, Beatrix, Cereatti, Andrea, Demeyer, Heleen, Hopkinson, Nicholas, Maetzler, Walter, Troosters, Thierry, Vogiatzis, Ioannis, Yarnall, Alison, Becker, Clemens, Garcia-Aymerich, Judith, Leocani, Letizia, Mazzà, Claudia, Rochester, Lynn, Sharrack, Basil, Frei, Anja, and Puhan, Milo

Published
2021
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16. Listening to the patients' voice: a conceptual framework of the walking experience

Author

Delgado-Ortiz, Laura; https://orcid.org/0000-0003-0311-7661, Polhemus, Ashley; https://orcid.org/0000-0002-5056-5785, Keogh, Alison, Sutton, Norman, Remmele, Werner, Hansen, Clint, Kluge, Felix, Sharrack, Basil, Becker, Clemens, Troosters, Thierry, Maetzler, Walter, Rochester, Lynn, Frei, Anja; https://orcid.org/0000-0002-7134-1000, Puhan, Milo A, Garcia-Aymerich, Judith, Delgado-Ortiz, Laura; https://orcid.org/0000-0003-0311-7661, Polhemus, Ashley; https://orcid.org/0000-0002-5056-5785, Keogh, Alison, Sutton, Norman, Remmele, Werner, Hansen, Clint, Kluge, Felix, Sharrack, Basil, Becker, Clemens, Troosters, Thierry, Maetzler, Walter, Rochester, Lynn, Frei, Anja; https://orcid.org/0000-0002-7134-1000, Puhan, Milo A, and Garcia-Aymerich, Judith

Abstract

BACKGROUND: walking is crucial for an active and healthy ageing, but the perspectives of individuals living with walking impairment are still poorly understood. OBJECTIVES: to identify and synthesise evidence describing walking as experienced by adults living with mobility-impairing health conditions and to propose an empirical conceptual framework of walking experience. METHODS: we performed a systematic review and meta-ethnography of qualitative evidence, searching seven electronic databases for records that explored personal experiences of walking in individuals living with conditions of diverse aetiology. Conditions included Parkinson's disease, multiple sclerosis, chronic obstructive pulmonary disease, hip fracture, heart failure, frailty and sarcopenia. Data were extracted, critically appraised using the NICE quality checklist and synthesised using standardised best practices. RESULTS: from 2,552 unique records, 117 were eligible. Walking experience was similar across conditions and described by seven themes: (i) becoming aware of the personal walking experience, (ii) the walking experience as a link between individuals' activities and sense of self, (iii) the physical walking experience, (iv) the mental and emotional walking experience, (v) the social walking experience, (vi) the context of the walking experience and (vii) behavioural and attitudinal adaptations resulting from the walking experience. We propose a novel conceptual framework that visually represents the walking experience, informed by the interplay between these themes. CONCLUSION: a multi-faceted and dynamic experience of walking was common across health conditions. Our conceptual framework of the walking experience provides a novel theoretical structure for patient-centred clinical practice, research and public health.

Published
2023

17. Ecological validity of a deep learning algorithm to detect gait events from real-life walking bouts in mobility-limiting diseases

Author

Romijnders, Robbin, primary, Salis, Francesca, additional, Hansen, Clint, additional, Küderle, Arne, additional, Paraschiv-Ionescu, Anisoara, additional, Cereatti, Andrea, additional, Alcock, Lisa, additional, Aminian, Kamiar, additional, Becker, Clemens, additional, Bertuletti, Stefano, additional, Bonci, Tecla, additional, Brown, Philip, additional, Buckley, Ellen, additional, Cantu, Alma, additional, Carsin, Anne-Elie, additional, Caruso, Marco, additional, Caulfield, Brian, additional, Chiari, Lorenzo, additional, D'Ascanio, Ilaria, additional, Del Din, Silvia, additional, Eskofier, Björn, additional, Fernstad, Sara Johansson, additional, Fröhlich, Marceli Stanislaw, additional, Garcia Aymerich, Judith, additional, Gazit, Eran, additional, Hausdorff, Jeffrey M., additional, Hiden, Hugo, additional, Hume, Emily, additional, Keogh, Alison, additional, Kirk, Cameron, additional, Kluge, Felix, additional, Koch, Sarah, additional, Mazzà, Claudia, additional, Megaritis, Dimitrios, additional, Micó-Amigo, Encarna, additional, Müller, Arne, additional, Palmerini, Luca, additional, Rochester, Lynn, additional, Schwickert, Lars, additional, Scott, Kirsty, additional, Sharrack, Basil, additional, Singleton, David, additional, Soltani, Abolfazl, additional, Ullrich, Martin, additional, Vereijken, Beatrix, additional, Vogiatzis, Ioannis, additional, Yarnall, Alison, additional, Schmidt, Gerhard, additional, and Maetzler, Walter, additional

Published
2023
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20. O.5.2-7 Listening to the patients’ voice: a conceptual framework of the walking experience

Author

Delgado-Ortiz, Laura, primary, Polhemus, Ashley, additional, Keogh, Alison, additional, Sutton, Norman, additional, Remmele, Werner, additional, Hansen, Clint, additional, Kluge, Felix, additional, Sharrack, Basil, additional, Becker, Clemens, additional, Troosters, Thierry, additional, Maetzler, Walter, additional, Rochester, Lynn, additional, Frei, Anja, additional, Puhan, Milo, additional, and Garcia-Aymerich, Judith, additional

Published
2023
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21. Comparing the Usability and Acceptability of Wearable Sensors Among Older Irish Adults in a Real-World Context: Observational Study

Author

Keogh, Alison, Dorn, Jonas F, Walsh, Lorcan, Calvo, Francesc, and Caulfield, Brian

Subjects
Information technology, T58.5-58.64, Public aspects of medicine, RA1-1270
Abstract

BackgroundWearable devices are valuable assessment tools for patient outcomes in contexts such as clinical trials. To be successfully deployed, however, participants must be willing to wear them. Another concern is that usability studies are rarely published, often fail to test devices beyond 24 hours, and need to be repeated frequently to ensure that contemporary devices are assessed. ObjectiveThis study aimed to compare multiple wearable sensors in a real-world context to establish their usability within an older adult (>50 years) population. MethodsEight older adults wore seven devices for a minimum of 1 week each: Actigraph GT9x, Actibelt, Actiwatch, Biovotion, Hexoskin, Mc10 Biostamp_RC, and Wavelet. Usability was established through mixed methods using semistructured interviews and three questionnaires, namely, the Intrinsic Motivation Inventory (IMI), the System Usability Scale (SUS), and an acceptability questionnaire. Quantitative data were reported descriptively and qualitative data were analyzed using deductive content analysis. Data were then integrated using triangulation. ResultsResults demonstrated that no device was considered optimal as all scored below average in the SUS (median, IQR; min-max=57.5, 12.5; 47.5-63.8). Hexoskin was the lowest scored device based on the IMI (3.6; 3.4-4.5), while Biovotion, Actibelt, and Mc10 Biostamp_RC achieved the highest median results on the acceptability questionnaire (3.6 on a 6-point Likert scale). Qualitatively, participants were willing to accept less comfort, less device discretion, and high charging burdens if the devices were perceived as useful, namely through the provision of feedback for the user. Participants agreed that the purpose of use is a key enabler for long-term compliance. These views were particularly noted by those not currently wearing an activity-tracking device. Participants believed that wrist-worn sensors were the most versatile and easy to use, and therefore, the most suitable for long-term use. In particular, Actiwatch and Wavelet stood out for their comfort. The convergence of quantitative and qualitative data was demonstrated in the study. ConclusionsBased on the results, the following context-specific recommendations can be made: (1) researchers should consider their device selection in relation to both individual and environmental factors, and not simply the primary outcome of the research study; (2) if researchers do not wish their participants to have access to feedback from the devices, then a simple, wrist-worn device that acts as a watch is preferable; (3) if feedback is allowed, then it should be made available to help participants remain engaged; this is likely to apply only to people without cognitive impairments; (4) battery life of 1 week should be considered as a necessary feature to enhance data capture; (5) researchers should consider providing additional information about the purpose of devices to participants to support their continued use.

Published
2020
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22. Real-World Gait Detection Using a Wrist-Worn Inertial Sensor: Validation Study (Preprint)

Author

Kluge, Felix, primary, Brand, Yonatan E, additional, Micó-Amigo, M Encarna, additional, Bertuletti, Stefano, additional, D'Ascanio, Ilaria, additional, Gazit, Eran, additional, Bonci, Tecla, additional, Kirk, Cameron, additional, Küderle, Arne, additional, Palmerini, Luca, additional, Paraschiv-Ionescu, Anisoara, additional, Salis, Francesca, additional, Soltani, Abolfazl, additional, Ullrich, Martin, additional, Alcock, Lisa, additional, Aminian, Kamiar, additional, Becker, Clemens, additional, Brown, Philip, additional, Buekers, Joren, additional, Carsin, Anne-Elie, additional, Caruso, Marco, additional, Caulfield, Brian, additional, Cereatti, Andrea, additional, Chiari, Lorenzo, additional, Echevarria, Carlos, additional, Eskofier, Bjoern, additional, Evers, Jordi, additional, Garcia-Aymerich, Judith, additional, Hache, Tilo, additional, Hansen, Clint, additional, Hausdorff, Jeffrey M, additional, Hiden, Hugo, additional, Hume, Emily, additional, Keogh, Alison, additional, Koch, Sarah, additional, Maetzler, Walter, additional, Megaritis, Dimitrios, additional, Niessen, Martijn, additional, Perlman, Or, additional, Schwickert, Lars, additional, Scott, Kirsty, additional, Sharrack, Basil, additional, Singleton, David, additional, Vereijken, Beatrix, additional, Vogiatzis, Ioannis, additional, Yarnall, Alison, additional, Rochester, Lynn, additional, Mazzà, Claudia, additional, Del Din, Silvia, additional, and Mueller, Arne, additional

Published
2023
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25. Newmont's Strategic Approach to Plant Optimization and Design is Paying Dividends: CEEC Medal winners inspire miners to add value and navigate to success

Author

Worden, Sandy and Keogh, Alison

Subjects
Fluor Corp. -- Securities, Mining industry -- Securities, Engineering services -- Securities, Energy conservation, Dividends, Manufacturing costs, Agricultural industry, Company securities, Business, Engineering and manufacturing industries, Petroleum, energy and mining industries
Abstract

Newmont Mining is achieving sustainable improvements in its comminution circuits by taking a strategic approach to plant optimization and design, and sharing leading grinding practices across its 11 gold mining [...]

Published
2019

26. Reverse Engineering of Digital Measures: Inviting Patients to the Conversation

Author

Clay, Ieuan, primary, Peerenboom, Nele, additional, Connors, Dana E, additional, Bourke, Steven, additional, Keogh, Alison, additional, Wac, Katarzyna, additional, Gur-Arie, Tova, additional, Baker, Justin, additional, Bull, Christopher, additional, Cereatti, Andrea, additional, Cormack, Francesca, additional, Eggenspieler, Damien, additional, Foschini, Luca, additional, Ganea, Raluca, additional, Groenen, Peter MA, additional, Gusset, Nicole, additional, Izmailova, Elena, additional, Kanzler, Christoph M, additional, Leyens, Lada, additional, Lyden, Kate, additional, Mueller, Arne, additional, Nam, Julian, additional, Ng, Wan-Fai, additional, Nobbs, David, additional, Orfaniotou, Foteini, additional, Perumal, Thanneer Malai, additional, Piwko, Wojciech, additional, Ries, Anja, additional, Scotland, Alf, additional, Taptiklis, Nick, additional, Torous, John, additional, Vereijken, Beatrix, additional, Xu, Shuai, additional, Baltzer, Laurenz, additional, Vetter, Thorsten, additional, Goldhahn, Jörg, additional, and Hoffmann, Steven C, additional

Published
2023
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27. Reverse Engineering of Digital Measures: Inviting Patients to the Conversation

Author

Clay, Ieuan, Peerenboom, Nele, Connors, Dana E, Bourke, Steven, Keogh, Alison, Wac, Katarzyna, Gur-Arieh, Tova, Baker, Justin, Bull, Christopher, Cereatti, Andrea, Cormack, Francesca, Eggenspieler, Damien, Foschini, Luca, Ganea, Raluca, Groenen, Peter M A, Gusset, Nicole, Izmailova, Elena, Kanzler, Christoph M, Leyens, Lada, Lyden, Kate, Mueller, Arne, Nam, Julian, Ng, Wan-Fai, Nobbs, David, Orfaniotou, Foteini, Perumal, Thanneer Malai, Piwko, Wojciech, Ries, Anja, Scotland, Alf, Taptiklis, Nick, Torous, John, Vereijken, Beatrix, Xu, Shuai, Baltzer, Laurenz, Vetter, Torstein, Goldhahn, Jörg, and Hoffmann, Steven C

Abstract

Background:Digital measures offer an unparalleled opportunity to create a more holistic picture of how people who are patients behave in their real-world environments, thereby establishing a better connection between patients, caregivers, and the clinical evidence used to drive drug development and disease management. Reaching this vision will require achieving a new level of co-creation between the stakeholders who design, develop, use, and make decisions using evidence from digital measures. Summary:In September 2022, the second in a series of meetings hosted by the Swiss Federal Institute of Technology in Zürich, the Foundation for the National Institutes of Health Biomarkers Consortium, and sponsored by Wellcome Trust, entitled "Reverse Engineering of Digital Measures," was held in Zurich, Switzerland, with a broad range of stakeholders sharing their experience across four case studies to examine how patient centricity is essential in shaping development and validation of digital evidence generation tools. Key messages:In this paper, we discuss progress and the remaining barriers to widespread use of digital measures for evidence generation in clinical development and care delivery. We also present key discussion points and takeaways in order to continue discourse and provide a basis for dissemination and outreach to the wider community and other stakeholders. The work presented here shows us a blueprint for how and why the patient voice can be thoughtfully integrated into digital measure development and that continued multistakeholder engagement is critical for further progress. Keywords:Co-creation; Digital measures; Meeting report; Multistakeholder engagement; Patient centricity.

Published
2023

29. Prediction Equations for Marathon Performance: A Systematic Review.

Author

Keogh, Alison, Smyth, Barry, Caulfield, Brian, Lawlor, Aonghus, Berndsen, Jakim, and Doherty, Cailbhe

Subjects
ALGORITHMS, ANTHROPOMETRY, ATHLETES, ATHLETIC ability, CLINICAL pathology, SCIENTIFIC observation, RESEARCH evaluation, SEX distribution, SYSTEMATIC reviews, PHYSICAL training & conditioning, LONG-distance running
Abstract

Purpose: Despite the volume of available literature focusing on marathon running and the prediction of performance, no single prediction equations exists that is accurate for all runners of varying experiences and abilities. Indeed the relative merits and utility of the existing equations remain unclear. Thus, the aim of this study was to collate, characterize, compare, and contrast all available marathon prediction equations. Methods: A systematic review was conducted to identify observational research studies outlining any kind of prediction algorithm for marathon performance. Results: Thirty-six studies with 114 equations were identified. Sixty-one equations were based on training and anthropometric variables, whereas 53 equations included variables that required laboratory tests and equipment. The accuracy of these equations was denoted via a variety of metrics; r² values were provided for 68 equations (r² = .10-.99), and an SEE was provided for 19 equations (SEE 0.27-27.4 min). Conclusion: Heterogeneity of the data precludes the identification of a single "best" equation. Important variables such as course gradient, sex, and expected weather conditions were often not included, and some widely used equations did not report the r value. Runners should therefore be wary of relying on a single equation to predict their performance. [ABSTRACT FROM AUTHOR]

Published
2019
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30. Listening to the patients’ voice: a conceptual framework of the walking experience

Author

Delgado-Ortiz, Laura, primary, Polhemus, Ashley, additional, Keogh, Alison, additional, Sutton, Norman, additional, Remmele, Werner, additional, Hansen, Clint, additional, Kluge, Felix, additional, Sharrack, Basil, additional, Becker, Clemens, additional, Troosters, Thierry, additional, Maetzler, Walter, additional, Rochester, Lynn, additional, Frei, Anja, additional, Puhan, Milo A, additional, and Garcia-Aymerich, Judith, additional

Published
2023
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31. Acceptability of wearable devices for measuring mobility remotely: Observations from the Mobilise-D technical validation study

Author

Keogh, Alison, primary, Alcock, Lisa, additional, Brown, Philip, additional, Buckley, Ellen, additional, Brozgol, Marina, additional, Gazit, Eran, additional, Hansen, Clint, additional, Scott, Kirsty, additional, Schwickert, Lars, additional, Becker, Clemens, additional, Hausdorff, Jeffrey M., additional, Maetzler, Walter, additional, Rochester, Lynn, additional, Sharrack, Basil, additional, Vogiatzis, Ioannis, additional, Yarnall, Alison, additional, Mazzà, Claudia, additional, and Caulfield, Brian, additional

Published
2023
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32. Reverse Engineering of Digital Measures: Inviting Patients to the Conversation

Author

Mueller, Arne, Nam, Julian, Ng, Wan Fai, Nobbs, David, Orfaniotou, Foteini, Perumal, Thanneer Malai, Piwko, Wojciech, Ries, Anja, Scotland, Alf, Taptiklis, Nick, Torous, John, Vereijken, Beatrix, Xu, Shuai, Baltzer, Laurenz, Vetter, Thorsten, Goldhahn, Jörg, Hoffmann, Steven C, clay, ieuan, Clay, Ieuan, Peerenboom, Nele, Connors, Dana E., Bourke, Steven, Keogh, Alison, Wac, Katarzyna, Gur-Arie, Tova, Baker, Justin, Bull, Christopher, Cereatti, Andrea, Cormack, Francesca, Eggenspieler, Damien, Foschini, Luca, Ganea, Raluca, Groenen, Peter M. A., Gusset, Nicole, Izmailova, Elena, Kanzler, Christoph M., Leyens, Lada, and Lyden, Kate

Subjects
Digital measures, patient centricity, Multistakeholder engagement, meeting report, co-creation
Abstract

Background: Digital measures offer an unparalleled opportunity to create a more holistic picture of how people who are patients behave in their real-world environments, thereby establishing a better connection between patients, caregivers, and the clinical evidence used to drive drug development and disease management. Reaching this vision will require achieving a new level of co-creation between the stakeholders who design, develop, use, and make decisions using evidence from digital measures. Summary: In September 2022, the second in a series of meetings hosted by the Swiss Federal Institute of Technology in Zürich, the Foundation for the National Institutes of Health Biomarkers Consortium, and sponsored by Wellcome Trust, entitled “Reverse Engineering of Digital Measures,” was held in Zurich, Switzerland, with a broad range of stakeholders sharing their experience across four case studies to examine how patient centricity is essential in shaping development and validation of digital evidence generation tools. Key Messages: In this paper, we discuss progress and the remaining barriers to widespread use of digital measures for evidence generation in clinical development and care delivery. We also present key discussion points and takeaways in order to continue discourse and provide a basis for dissemination and outreach to the wider community and other stakeholders. The work presented here shows us a blueprint for how and why the patient voice can be thoughtfully integrated into digital measure development and that continued multistakeholder engagement is critical for further progress., Digital Biomarkers, 7 (1), ISSN:2504-110X

Published
2023
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33. sj-docx-1-dhj-10.1177_20552076221150745 - Supplemental material for Acceptability of wearable devices for measuring mobility remotely: Observations from the Mobilise-D technical validation study

Author

Keogh, Alison, Alcock, Lisa, Brown, Philip, Buckley, Ellen, Brozgol, Marina, Gazit, Eran, Hansen, Clint, Scott, Kirsty, Schwickert, Lars, Becker, Clemens, Hausdorff, Jeffrey M., Maetzler, Walter, Rochester, Lynn, Sharrack, Basil, Vogiatzis, Ioannis, Yarnall, Alison, Mazzà, Claudia, and Caulfield, Brian

Subjects
FOS: Computer and information sciences, 200299 Cultural Studies not elsewhere classified, Science Policy, FOS: Clinical medicine, FOS: Political science, 150310 Organisation and Management Theory, Cardiology, 111799 Public Health and Health Services not elsewhere classified, FOS: Health sciences, 110306 Endocrinology, 110308 Geriatrics and Gerontology, 99999 Engineering not elsewhere classified, FOS: Sociology, FOS: Economics and business, 111099 Nursing not elsewhere classified, FOS: Other engineering and technologies, Sociology, 111708 Health and Community Services, Anthropology, 111702 Aged Health Care, 89999 Information and Computing Sciences not elsewhere classified, FOS: Other humanities, 160512 Social Policy, 111299 Oncology and Carcinogenesis not elsewhere classified
Abstract

Supplemental material, sj-docx-1-dhj-10.1177_20552076221150745 for Acceptability of wearable devices for measuring mobility remotely: Observations from the Mobilise-D technical validation study by Alison Keogh, Lisa Alcock, Philip Brown, Ellen Buckley, Marina Brozgol, Eran Gazit, Clint Hansen, Kirsty Scott, Lars Schwickert, Clemens Becker, Jeffrey M. Hausdorff, Walter Maetzler, Lynn Rochester, Basil Sharrack, Ioannis Vogiatzis, Alison Yarnall, Claudia Mazzà and Brian Caulfield in Digital Health

Published
2023
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34. Feasibility of Training Physical Therapists to Deliver the Theory-Based Self-Management of Osteoarthritis and Low Back Pain Through Activity and Skills (SOLAS) Intervention Within a Trial

Author

Keogh, Alison, Matthews, James, Segurado, Ricardo, and Hurley, Deirdre A.

Subjects
Self care (Health) -- Training, Low back pain -- Care and treatment, Osteoarthritis -- Care and treatment, Physical therapists -- Training, Health
Abstract

Background. Provider training programs are frequently underevaluated, leading to ambiguity surrounding effective intervention components. Objective. The purpose of this study was to assess the effectiveness of a training program in [...]

Published
2018
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35. Assessing real-world gait with digital technology? Validation, insights and recommendations from the Mobilise-D consortium

Author

Micó-Amigo, M. Encarna, primary, Bonci, Tecla, additional, Paraschiv-Ionescu, Anisoara, additional, Ullrich, Martin, additional, Kirk, Cameron, additional, Soltani, Abolfazl, additional, Küderle, Arne, additional, Gazit, Eran, additional, Salis, Francesca, additional, Alcock, Lisa, additional, Aminian, Kamiar, additional, Becker, Clemens, additional, Bertuletti, Stefano, additional, Brown, Philip, additional, Buckley, Ellen, additional, Cantu, Alma, additional, Carsin, Anne-Elie, additional, Caruso, Marco, additional, Caulfield, Brian, additional, Cereatti, Andrea, additional, Chiari, Lorenzo, additional, D’Ascanio, Ilaria, additional, Eskofier, Bjoern, additional, Fernstad, Sara, additional, Froehlich, Marcel, additional, Garcia-Aymerich, Judith, additional, Hansen, Clint, additional, Hausdorff, Jeff, additional, Hiden, Hugo, additional, Hume, Emily, additional, Keogh, Alison, additional, Kluge, Felix, additional, Koch, Sarah, additional, Maetzler, Walter, additional, Megaritis, Dimitrios, additional, Mueller, Arne, additional, Niessen, Martijn, additional, Palmerini, Luca, additional, Schwickert, Lars, additional, Scott, Kirsty, additional, Sharrack, Basil, additional, Sillén, Henrik, additional, Singleton, David, additional, Vereijken, Beatrix, additional, Vogiatzis, Ioannis, additional, Yarnall, Alison, additional, Rochester, Lynn, additional, Mazza, Claudia, additional, and Din, Silvia Del, additional

Published
2022
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36. Design and validation of a multi-task, multi-phase protocol for real-world gait simulation

Author

Scott, Kirsty, primary, Bonci, Tecla, additional, Francesca, Salis, additional, Alcock, Lisa, additional, Buckley, Ellen, additional, Gazit, Eran, additional, Hansen, Clint, additional, Schwickert, Lars, additional, Aminian, Kamiar, additional, Bertuletti, Stefano, additional, Caruso, Marco, additional, Chiari, Lorenzo, additional, Sharrack, Basil, additional, Maetzler, Walter, additional, Becker, Clemens, additional, Haussdorff, Jeffrey M., additional, Vogiatzis, Ioannis, additional, Brown, Philip, additional, Din, Silvia Del, additional, Eskofier, Björn, additional, Paraschiv-Ionescu, Anisoara, additional, Keogh, Alison, additional, Cameron, Kirk, additional, Kluge, Felix, additional, Micó-Amigo, M. Encarna, additional, Mueller, Arne, additional, Neatrur, Isabel, additional, Niessen, Martijn, additional, Palmerini, Luca, additional, Sillen, Henrik, additional, Singleton, David, additional, Ullrich, Martin, additional, Vereijken, Beatrix, additional, Froelich, Marcel, additional, Brittan, Gavin, additional, Caulfield, Brian, additional, Koch, Sarah, additional, Carsin, Anne-Elie, additional, Garcia-Aymerich, Judith, additional, Kuederle, Arne, additional, Yarnall, Alison, additional, Cereatti, Andrea, additional, and Mazzà, Claudia, additional

Published
2022
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38. Technical validation of real-world monitoring of gait: a multicentric observational study

Author

Mazzà, Claudia, primary, Alcock, Lisa, additional, Aminian, Kamiar, additional, Becker, Clemens, additional, Bertuletti, Stefano, additional, Bonci, Tecla, additional, Brown, Philip, additional, Brozgol, Marina, additional, Buckley, Ellen, additional, Carsin, Anne-Elie, additional, Caruso, Marco, additional, Caulfield, Brian, additional, Cereatti, Andrea, additional, Chiari, Lorenzo, additional, Chynkiamis, Nikolaos, additional, Ciravegna, Fabio, additional, Del Din, Silvia, additional, Eskofier, Björn, additional, Evers, Jordi, additional, Garcia Aymerich, Judith, additional, Gazit, Eran, additional, Hansen, Clint, additional, Hausdorff, Jeffrey M, additional, Helbostad, Jorunn L, additional, Hiden, Hugo, additional, Hume, Emily, additional, Paraschiv-Ionescu, Anisoara, additional, Ireson, Neil, additional, Keogh, Alison, additional, Kirk, Cameron, additional, Kluge, Felix, additional, Koch, Sarah, additional, Küderle, Arne, additional, Lanfranchi, Vitaveska, additional, Maetzler, Walter, additional, Micó-Amigo, M Encarna, additional, Mueller, Arne, additional, Neatrour, Isabel, additional, Niessen, Martijn, additional, Palmerini, Luca, additional, Pluimgraaff, Lucas, additional, Reggi, Luca, additional, Salis, Francesca, additional, Schwickert, Lars, additional, Scott, Kirsty, additional, Sharrack, Basil, additional, Sillen, Henrik, additional, Singleton, David, additional, Soltani, Abolfazi, additional, Taraldsen, Kristin, additional, Ullrich, Martin, additional, Van Gelder, Linda, additional, Vereijken, Beatrix, additional, Vogiatzis, Ioannis, additional, Warmerdam, Elke, additional, Yarnall, Alison, additional, and Rochester, Lynn, additional

Published
2021
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40. Additional file 2 of It’s not about the capture, it’s about what we can learn': a qualitative study of experts’ opinions and experiences regarding the use of wearable sensors to measure gait and physical activity

Author

Keogh, Alison, Taraldsen, Kristin, Caulfield, Brian, and Vereijken, Beatrix

Subjects
Data_FILES, GeneralLiterature_REFERENCE(e.g.,dictionaries,encyclopedias,glossaries)
Abstract

Additional file 2. Expert interviews for Mobilise-D—Coding book.

Published
2021
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42. Additional file 1 of It’s not about the capture, it’s about what we can learn': a qualitative study of experts’ opinions and experiences regarding the use of wearable sensors to measure gait and physical activity

Author

Keogh, Alison, Taraldsen, Kristin, Caulfield, Brian, and Vereijken, Beatrix

Subjects
ComputingMilieux_COMPUTERSANDSOCIETY
Abstract

Additional file 1. Expert learnings regarding the use of wearables in healthcare research to measure PA in older adults.

Published
2021
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44. Additional file 4 of Feasibility cluster randomised controlled trial evaluating a theory-driven group-based complex intervention versus usual physiotherapy to support self-management of osteoarthritis and low back pain (SOLAS)

Author

Hurley, Deirdre A., Jeffares, Isabelle, Hall, Amanda M., Keogh, Alison, Toomey, Elaine, McArdle, Danielle, McDonough, Suzanne M., Guerin, Suzanne, Segurado, Ricardo, and Matthews, James

Abstract

Additional file 4. Physiotherapist Baseline Characteristics.

Published
2020
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45. Additional file 5 of Feasibility cluster randomised controlled trial evaluating a theory-driven group-based complex intervention versus usual physiotherapy to support self-management of osteoarthritis and low back pain (SOLAS)

Author

Hurley, Deirdre A., Jeffares, Isabelle, Hall, Amanda M., Keogh, Alison, Toomey, Elaine, McArdle, Danielle, McDonough, Suzanne M., Guerin, Suzanne, Segurado, Ricardo, and Matthews, James

Abstract

Additional file 5. SOLAS Intervention Sites, Physiotherapists and Participants.

Published
2020
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46. Additional file 10 of Feasibility cluster randomised controlled trial evaluating a theory-driven group-based complex intervention versus usual physiotherapy to support self-management of osteoarthritis and low back pain (SOLAS)

Author

Hurley, Deirdre A., Jeffares, Isabelle, Hall, Amanda M., Keogh, Alison, Toomey, Elaine, McArdle, Danielle, McDonough, Suzanne M., Guerin, Suzanne, Segurado, Ricardo, and Matthews, James

Abstract

Additional file 10. Model-predicted mean (95% CI) behaviour change process model outcomes per group over time.

Published
2020
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47. Additional file 9 of Feasibility cluster randomised controlled trial evaluating a theory-driven group-based complex intervention versus usual physiotherapy to support self-management of osteoarthritis and low back pain (SOLAS)

Author

Hurley, Deirdre A., Jeffares, Isabelle, Hall, Amanda M., Keogh, Alison, Toomey, Elaine, McArdle, Danielle, McDonough, Suzanne M., Guerin, Suzanne, Segurado, Ricardo, and Matthews, James

Abstract

Additional file 9. Baseline sociodemographic variables.

Published
2020
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48. Additional file 2 of Feasibility cluster randomised controlled trial evaluating a theory-driven group-based complex intervention versus usual physiotherapy to support self-management of osteoarthritis and low back pain (SOLAS)

Author

Hurley, Deirdre A., Jeffares, Isabelle, Hall, Amanda M., Keogh, Alison, Toomey, Elaine, McArdle, Danielle, McDonough, Suzanne M., Guerin, Suzanne, Segurado, Ricardo, and Matthews, James

Subjects
sense organs, skin and connective tissue diseases
Abstract

Additional file 2. Secondary Outcomes and Process Model of Behaviour Change Measures.

Published
2020
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49. Additional file 8 of Feasibility cluster randomised controlled trial evaluating a theory-driven group-based complex intervention versus usual physiotherapy to support self-management of osteoarthritis and low back pain (SOLAS)

Author

Hurley, Deirdre A., Jeffares, Isabelle, Hall, Amanda M., Keogh, Alison, Toomey, Elaine, McArdle, Danielle, McDonough, Suzanne M., Guerin, Suzanne, Segurado, Ricardo, and Matthews, James

Abstract

Additional file 8. Consolidated Criteria for Reporting Qualitative Research (COREQ) Guidelines for Physiotherapist and Participant interviews.

Published
2020
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50. Additional file 3 of Feasibility cluster randomised controlled trial evaluating a theory-driven group-based complex intervention versus usual physiotherapy to support self-management of osteoarthritis and low back pain (SOLAS)

Author

Hurley, Deirdre A., Jeffares, Isabelle, Hall, Amanda M., Keogh, Alison, Toomey, Elaine, McArdle, Danielle, McDonough, Suzanne M., Guerin, Suzanne, Segurado, Ricardo, and Matthews, James

Abstract

Additional file 3. Qualitative Interview Methods and Results.

Published
2020
Full Text
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