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1. Zinc Finger MYND-Type Containing 8 (ZMYND8) Is Epigenetically Regulated in Mutant Isocitrate Dehydrogenase 1 (IDH1) Glioma to Promote Radioresistance.

Author

Carney, Stephen, Banerjee, Kaushik, Mujeeb, Anzar, Zhu, Brandon, Haase, Santiago, Varela, Maria, Kadiyala, Padma, Tronrud, Claire, Zhu, Ziwen, Mukherji, Devarshi, Gorla, Preethi, Sun, Yilun, Tagett, Rebecca, Núñez, Felipe, Luo, Maowu, Luo, Weibo, Ljungman, Mats, Liu, Yayuan, Xia, Ziyun, Schwendeman, Anna, Qin, Tingting, Sartor, Maureen, Cahill, Daniel, Lowenstein, Pedro, Castro, Maria, and Costello, Joseph

Subjects
Humans, Isocitrate Dehydrogenase, MYND Domains, Epigenesis, Genetic, Nuclear Proteins, Poly(ADP-ribose) Polymerase Inhibitors, Transcription Factors, Glioma, Cell Cycle Proteins
Abstract

PURPOSE: Mutant isocitrate dehydrogenase 1 (mIDH1) alters the epigenetic regulation of chromatin, leading to a hypermethylation phenotype in adult glioma. This work focuses on identifying gene targets epigenetically dysregulated by mIDH1 to confer therapeutic resistance to ionizing radiation (IR). EXPERIMENTAL DESIGN: We evaluated changes in the transcriptome and epigenome in a radioresistant mIDH1 patient-derived glioma cell culture (GCC) following treatment with an mIDH1-specific inhibitor, AGI-5198. We identified Zinc Finger MYND-Type Containing 8 (ZMYND8) as a potential target of mIDH1 reprogramming. We suppressed ZMYND8 expression by shRNA knockdown and genetic knockout (KO) in mIDH1 glioma cells and then assessed cellular viability to IR. We assessed the sensitivity of mIDH1 GCCS to pharmacologic inhibition of ZMYND8-interacting partners: HDAC, BRD4, and PARP. RESULTS: Inhibition of mIDH1 leads to an upregulation of gene networks involved in replication stress. We found that the expression of ZMYND8, a regulator of DNA damage response, was decreased in three patient-derived mIDH1 GCCs after treatment with AGI-5198. Knockdown of ZMYND8 expression sensitized mIDH1 GCCs to radiotherapy marked by decreased cellular viability. Following IR, mIDH1 glioma cells with ZMYND8 KO exhibit significant phosphorylation of ATM and sustained γH2AX activation. ZMYND8 KO mIDH1 GCCs were further responsive to IR when treated with either BRD4 or HDAC inhibitors. PARP inhibition further enhanced the efficacy of radiotherapy in ZMYND8 KO mIDH1 glioma cells. CONCLUSIONS: These findings indicate the impact of ZMYND8 in the maintenance of genomic integrity and repair of IR-induced DNA damage in mIDH1 glioma. See related commentary by Sachdev et al., p. 1648.

Published
2023

3. Supplementary Figures S1-S17 from Zinc Finger MYND-Type Containing 8 (ZMYND8) Is Epigenetically Regulated in Mutant Isocitrate Dehydrogenase 1 (IDH1) Glioma to Promote Radioresistance

Author

Carney, Stephen V., primary, Banerjee, Kaushik, primary, Mujeeb, Anzar, primary, Zhu, Brandon, primary, Haase, Santiago, primary, Varela, Maria L., primary, Kadiyala, Padma, primary, Tronrud, Claire E., primary, Zhu, Ziwen, primary, Mukherji, Devarshi, primary, Gorla, Preethi, primary, Sun, Yilun, primary, Tagett, Rebecca, primary, Núñez, Felipe J., primary, Luo, Maowu, primary, Luo, Weibo, primary, Ljungman, Mats, primary, Liu, Yayuan, primary, Xia, Ziyun, primary, Schwendeman, Anna, primary, Qin, Tingting, primary, Sartor, Maureen A., primary, Costello, Joseph F., primary, Cahill, Daniel P., primary, Lowenstein, Pedro R., primary, and Castro, Maria G., primary

Published
2024
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4. Supplementary Table S2 from Zinc Finger MYND-Type Containing 8 (ZMYND8) Is Epigenetically Regulated in Mutant Isocitrate Dehydrogenase 1 (IDH1) Glioma to Promote Radioresistance

Author

Carney, Stephen V., primary, Banerjee, Kaushik, primary, Mujeeb, Anzar, primary, Zhu, Brandon, primary, Haase, Santiago, primary, Varela, Maria L., primary, Kadiyala, Padma, primary, Tronrud, Claire E., primary, Zhu, Ziwen, primary, Mukherji, Devarshi, primary, Gorla, Preethi, primary, Sun, Yilun, primary, Tagett, Rebecca, primary, Núñez, Felipe J., primary, Luo, Maowu, primary, Luo, Weibo, primary, Ljungman, Mats, primary, Liu, Yayuan, primary, Xia, Ziyun, primary, Schwendeman, Anna, primary, Qin, Tingting, primary, Sartor, Maureen A., primary, Costello, Joseph F., primary, Cahill, Daniel P., primary, Lowenstein, Pedro R., primary, and Castro, Maria G., primary

Published
2024
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5. Data from Zinc Finger MYND-Type Containing 8 (ZMYND8) Is Epigenetically Regulated in Mutant Isocitrate Dehydrogenase 1 (IDH1) Glioma to Promote Radioresistance

Author

Carney, Stephen V., primary, Banerjee, Kaushik, primary, Mujeeb, Anzar, primary, Zhu, Brandon, primary, Haase, Santiago, primary, Varela, Maria L., primary, Kadiyala, Padma, primary, Tronrud, Claire E., primary, Zhu, Ziwen, primary, Mukherji, Devarshi, primary, Gorla, Preethi, primary, Sun, Yilun, primary, Tagett, Rebecca, primary, Núñez, Felipe J., primary, Luo, Maowu, primary, Luo, Weibo, primary, Ljungman, Mats, primary, Liu, Yayuan, primary, Xia, Ziyun, primary, Schwendeman, Anna, primary, Qin, Tingting, primary, Sartor, Maureen A., primary, Costello, Joseph F., primary, Cahill, Daniel P., primary, Lowenstein, Pedro R., primary, and Castro, Maria G., primary

Published
2024
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6. Supplementary Methods S1 from Zinc Finger MYND-Type Containing 8 (ZMYND8) Is Epigenetically Regulated in Mutant Isocitrate Dehydrogenase 1 (IDH1) Glioma to Promote Radioresistance

Author

Carney, Stephen V., primary, Banerjee, Kaushik, primary, Mujeeb, Anzar, primary, Zhu, Brandon, primary, Haase, Santiago, primary, Varela, Maria L., primary, Kadiyala, Padma, primary, Tronrud, Claire E., primary, Zhu, Ziwen, primary, Mukherji, Devarshi, primary, Gorla, Preethi, primary, Sun, Yilun, primary, Tagett, Rebecca, primary, Núñez, Felipe J., primary, Luo, Maowu, primary, Luo, Weibo, primary, Ljungman, Mats, primary, Liu, Yayuan, primary, Xia, Ziyun, primary, Schwendeman, Anna, primary, Qin, Tingting, primary, Sartor, Maureen A., primary, Costello, Joseph F., primary, Cahill, Daniel P., primary, Lowenstein, Pedro R., primary, and Castro, Maria G., primary

Published
2024
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7. Epigenetic Reprogramming of Autophagy Drives Mutant IDH1 Glioma Progression and Response to Radiation

Author

Núñez, Felipe J, primary, Banerjee, Kaushik, additional, Mujeeb, Anzar A., additional, Mauser, Ava, additional, Tronrud, Claire E., additional, Zhu, Ziwen, additional, Taher, Ayman, additional, Kadiyala, Padma, additional, Carney, Stephen V., additional, Garcia-Fabiani, Maria B., additional, Comba, Andrea, additional, Alghamri, Mahmoud S., additional, McClellan, Brandon L., additional, Faisal, Syed M., additional, Nwosu, Zeribe C., additional, Hong, Hanna S., additional, Qin, Tingting, additional, Sartor, Maureen A., additional, Ljungman, Mats, additional, Cheng, Shi-Yuan, additional, Appelman, Henry D., additional, Lowenstein, Pedro R., additional, Lahann, Joerg, additional, Lyssiotis, Costas A., additional, and Castro, Maria G., additional

Published
2024
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10. KRT17High/CXCL8+ tumor cells display both classical and basal features and regulate myeloid infiltration in the pancreatic cancer microenvironment

Author

Carpenter, Eileen S., primary, Kadiyala, Padma, additional, Elhossiny, Ahmed M., additional, Kemp, Samantha B., additional, Li, Jay, additional, Steele, Nina G., additional, Nicolle, Rémy, additional, Nwosu, Zeribe C., additional, Freeman, Julia, additional, Dai, Henry, additional, Paglia, Daniel, additional, Du, Wenting, additional, Donahue, Katelyn, additional, Morales, Jacqueline, additional, Medina-Cabrera, Paola I., additional, Bonilla, Monica E., additional, Harris, Lindsey, additional, The, Stephanie, additional, Gunchick, Valerie, additional, Peterson, Nicole, additional, Brown, Kristee, additional, Mattea, Michael, additional, Espinoza, Carlos E., additional, McGue, Jake, additional, Kabala, Sarah M., additional, Baliira, Rachel K., additional, Renollet, Nur M., additional, Mooney, Ayden G., additional, Liu, Jianhua, additional, Bhalla, Sean, additional, Farida, Jeremy P., additional, Ko, Christopher, additional, Machicado, Jorge D., additional, Kwon, Richard S., additional, Wamsteker, Erik-Jan, additional, Schulman, Allison, additional, Anderson, Michelle A., additional, Law, Ryan, additional, Prabhu, Anoop, additional, Coulombe, Pierre A., additional, Rao, Arvind, additional, Frankel, Timothy L., additional, Bednar, Filip, additional, Shi, Jiaqi, additional, Sahai, Vaibhav, additional, and Pasca di Magliano, Marina, additional

Published
2023
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11. Isolation and characterization of immune cells from the tumor microenvironment of genetically engineered pediatric high-grade glioma models using the sleeping beauty transposon system

Author

Garcia-Fabiani, Maria Belen, primary, Comba, Andrea, additional, Kadiyala, Padma, additional, Haase, Santiago, additional, Núñez, Felipe Javier, additional, Altshuler, David, additional, Lowenstein, Pedro Ricardo, additional, and Castro, Maria Graciela, additional

Published
2020
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15. Supplementary Tables from Analysis of Donor Pancreata Defines the Transcriptomic Signature and Microenvironment of Early Neoplastic Lesions

Author

Carpenter, Eileen S., primary, Elhossiny, Ahmed M., primary, Kadiyala, Padma, primary, Li, Jay, primary, McGue, Jake, primary, Griffith, Brian D., primary, Zhang, Yaqing, primary, Edwards, Jacob, primary, Nelson, Sarah, primary, Lima, Fatima, primary, Donahue, Katelyn L., primary, Du, Wenting, primary, Bischoff, Allison C., primary, Alomari, Danyah, primary, Watkoske, Hannah R., primary, Mattea, Michael, primary, The, Stephanie, primary, Espinoza, Carlos E., primary, Barrett, Meredith, primary, Sonnenday, Christopher J., primary, Olden, Nicholas, primary, Chen, Chin-Tung, primary, Peterson, Nicole, primary, Gunchick, Valerie, primary, Sahai, Vaibhav, primary, Rao, Arvind, primary, Bednar, Filip, primary, Shi, Jiaqi, primary, Frankel, Timothy L., primary, and Pasca di Magliano, Marina, primary

Published
2023
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16. Supplementary Figures Part 2 from Analysis of Donor Pancreata Defines the Transcriptomic Signature and Microenvironment of Early Neoplastic Lesions

Author

Carpenter, Eileen S., primary, Elhossiny, Ahmed M., primary, Kadiyala, Padma, primary, Li, Jay, primary, McGue, Jake, primary, Griffith, Brian D., primary, Zhang, Yaqing, primary, Edwards, Jacob, primary, Nelson, Sarah, primary, Lima, Fatima, primary, Donahue, Katelyn L., primary, Du, Wenting, primary, Bischoff, Allison C., primary, Alomari, Danyah, primary, Watkoske, Hannah R., primary, Mattea, Michael, primary, The, Stephanie, primary, Espinoza, Carlos E., primary, Barrett, Meredith, primary, Sonnenday, Christopher J., primary, Olden, Nicholas, primary, Chen, Chin-Tung, primary, Peterson, Nicole, primary, Gunchick, Valerie, primary, Sahai, Vaibhav, primary, Rao, Arvind, primary, Bednar, Filip, primary, Shi, Jiaqi, primary, Frankel, Timothy L., primary, and Pasca di Magliano, Marina, primary

Published
2023
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17. Data from Analysis of Donor Pancreata Defines the Transcriptomic Signature and Microenvironment of Early Neoplastic Lesions

Author

Carpenter, Eileen S., primary, Elhossiny, Ahmed M., primary, Kadiyala, Padma, primary, Li, Jay, primary, McGue, Jake, primary, Griffith, Brian D., primary, Zhang, Yaqing, primary, Edwards, Jacob, primary, Nelson, Sarah, primary, Lima, Fatima, primary, Donahue, Katelyn L., primary, Du, Wenting, primary, Bischoff, Allison C., primary, Alomari, Danyah, primary, Watkoske, Hannah R., primary, Mattea, Michael, primary, The, Stephanie, primary, Espinoza, Carlos E., primary, Barrett, Meredith, primary, Sonnenday, Christopher J., primary, Olden, Nicholas, primary, Chen, Chin-Tung, primary, Peterson, Nicole, primary, Gunchick, Valerie, primary, Sahai, Vaibhav, primary, Rao, Arvind, primary, Bednar, Filip, primary, Shi, Jiaqi, primary, Frankel, Timothy L., primary, and Pasca di Magliano, Marina, primary

Published
2023
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18. Supplementary Figures Part 1 from Analysis of Donor Pancreata Defines the Transcriptomic Signature and Microenvironment of Early Neoplastic Lesions

Author

Carpenter, Eileen S., primary, Elhossiny, Ahmed M., primary, Kadiyala, Padma, primary, Li, Jay, primary, McGue, Jake, primary, Griffith, Brian D., primary, Zhang, Yaqing, primary, Edwards, Jacob, primary, Nelson, Sarah, primary, Lima, Fatima, primary, Donahue, Katelyn L., primary, Du, Wenting, primary, Bischoff, Allison C., primary, Alomari, Danyah, primary, Watkoske, Hannah R., primary, Mattea, Michael, primary, The, Stephanie, primary, Espinoza, Carlos E., primary, Barrett, Meredith, primary, Sonnenday, Christopher J., primary, Olden, Nicholas, primary, Chen, Chin-Tung, primary, Peterson, Nicole, primary, Gunchick, Valerie, primary, Sahai, Vaibhav, primary, Rao, Arvind, primary, Bednar, Filip, primary, Shi, Jiaqi, primary, Frankel, Timothy L., primary, and Pasca di Magliano, Marina, primary

Published
2023
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19. Supplementary Table S1 from Zinc Finger MYND-Type Containing 8 (ZMYND8) Is Epigenetically Regulated in Mutant Isocitrate Dehydrogenase 1 (IDH1) Glioma to Promote Radioresistance

Author

Carney, Stephen V., primary, Banerjee, Kaushik, primary, Mujeeb, Anzar, primary, Zhu, Brandon, primary, Haase, Santiago, primary, Varela, Maria L., primary, Kadiyala, Padma, primary, Tronrud, Claire E., primary, Zhu, Ziwen, primary, Mukherji, Devarshi, primary, Gorla, Preethi, primary, Sun, Yilun, primary, Tagett, Rebecca, primary, Núñez, Felipe J., primary, Luo, Maowu, primary, Luo, Weibo, primary, Ljungman, Mats, primary, Liu, Yayuan, primary, Xia, Ziyun, primary, Schwendeman, Anna, primary, Qin, Tingting, primary, Sartor, Maureen A., primary, Costello, Joseph F., primary, Cahill, Daniel P., primary, Lowenstein, Pedro R., primary, and Castro, Maria G., primary

Published
2023
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20. Data from Zinc Finger MYND-Type Containing 8 (ZMYND8) Is Epigenetically Regulated in Mutant Isocitrate Dehydrogenase 1 (IDH1) Glioma to Promote Radioresistance

Author

Carney, Stephen V., primary, Banerjee, Kaushik, primary, Mujeeb, Anzar, primary, Zhu, Brandon, primary, Haase, Santiago, primary, Varela, Maria L., primary, Kadiyala, Padma, primary, Tronrud, Claire E., primary, Zhu, Ziwen, primary, Mukherji, Devarshi, primary, Gorla, Preethi, primary, Sun, Yilun, primary, Tagett, Rebecca, primary, Núñez, Felipe J., primary, Luo, Maowu, primary, Luo, Weibo, primary, Ljungman, Mats, primary, Liu, Yayuan, primary, Xia, Ziyun, primary, Schwendeman, Anna, primary, Qin, Tingting, primary, Sartor, Maureen A., primary, Costello, Joseph F., primary, Cahill, Daniel P., primary, Lowenstein, Pedro R., primary, and Castro, Maria G., primary

Published
2023
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21. Supplementary Methods S1 from Zinc Finger MYND-Type Containing 8 (ZMYND8) Is Epigenetically Regulated in Mutant Isocitrate Dehydrogenase 1 (IDH1) Glioma to Promote Radioresistance

Author

Carney, Stephen V., primary, Banerjee, Kaushik, primary, Mujeeb, Anzar, primary, Zhu, Brandon, primary, Haase, Santiago, primary, Varela, Maria L., primary, Kadiyala, Padma, primary, Tronrud, Claire E., primary, Zhu, Ziwen, primary, Mukherji, Devarshi, primary, Gorla, Preethi, primary, Sun, Yilun, primary, Tagett, Rebecca, primary, Núñez, Felipe J., primary, Luo, Maowu, primary, Luo, Weibo, primary, Ljungman, Mats, primary, Liu, Yayuan, primary, Xia, Ziyun, primary, Schwendeman, Anna, primary, Qin, Tingting, primary, Sartor, Maureen A., primary, Costello, Joseph F., primary, Cahill, Daniel P., primary, Lowenstein, Pedro R., primary, and Castro, Maria G., primary

Published
2023
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22. Supplementary Figures S1-S17 from Zinc Finger MYND-Type Containing 8 (ZMYND8) Is Epigenetically Regulated in Mutant Isocitrate Dehydrogenase 1 (IDH1) Glioma to Promote Radioresistance

Author

Carney, Stephen V., primary, Banerjee, Kaushik, primary, Mujeeb, Anzar, primary, Zhu, Brandon, primary, Haase, Santiago, primary, Varela, Maria L., primary, Kadiyala, Padma, primary, Tronrud, Claire E., primary, Zhu, Ziwen, primary, Mukherji, Devarshi, primary, Gorla, Preethi, primary, Sun, Yilun, primary, Tagett, Rebecca, primary, Núñez, Felipe J., primary, Luo, Maowu, primary, Luo, Weibo, primary, Ljungman, Mats, primary, Liu, Yayuan, primary, Xia, Ziyun, primary, Schwendeman, Anna, primary, Qin, Tingting, primary, Sartor, Maureen A., primary, Costello, Joseph F., primary, Cahill, Daniel P., primary, Lowenstein, Pedro R., primary, and Castro, Maria G., primary

Published
2023
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24. H3.3-G34R Mutation-Mediated Epigenetic Reprogramming Leads to Enhanced Efficacy of Immune Stimulatory Gene Therapy in Pediatric High-Grade Gliomas

Author

Garcia-Fabiani, Maria B., Haase, Santiago, Banerjee, Kaushik, McClellan, Brandon, Zhu, Ziwen, Mujeeb, Anzar, Li, Yingxiang, Yu, Jin, Kadiyala, Padma, Taher, Ayman, Núñez, Felipe J., Alghamri, Mahmoud S., Comba, Andrea, Mendez, Flor M., Nicola Candia, Alejandro J., Salazar, Brittany, Koschmann, Carl, Nunez, Fernando M., Edwards, Marta, Qin, Tingting, Sartor, Maureen A., Lowenstein, Pedro R., and Castro, Maria G.

Subjects
Article
Abstract

Pediatric high-grade gliomas (pHGGs) are diffuse and highly aggressive CNS tumors which remain incurable, with a 5-year overall survival of less than 20%. Within glioma, mutations in the genes encoding the histones H3.1 and H3.3 have been discovered to be age-restricted and specific of pHGGs. This work focuses on the study of pHGGs harboring the H3.3-G34R mutation. H3.3-G34R tumors represent the 9-15% of pHGGs, are restricted to the cerebral hemispheres, and are found predominantly in the adolescent population (median 15.0 years). We have utilized a genetically engineered immunocompetent mouse model for this subtype of pHGG generated via the Sleeping Beauty-transposon system. The analysis of H3.3-G34R genetically engineered brain tumors by RNA-Sequencing and ChIP-Sequencing revealed alterations in the molecular landscape associated to H3.3-G34R expression. In particular, the expression of H3.3-G34R modifies the histone marks deposited at the regulatory elements of genes belonging to the JAK/STAT pathway, leading to an increased activation of this pathway. This histone G34R-mediated epigenetic modifications lead to changes in the tumor immune microenvironment of these tumors, towards an immune-permissive phenotype, making these gliomas susceptible to TK/Flt3L immune-stimulatory gene therapy. The application of this therapeutic approach increased median survival of H3.3-G34R tumor bearing animals, while stimulating the development of anti-tumor immune response and immunological memory. Our data suggests that the proposed immune-mediated gene therapy has potential for clinical translation for the treatment of patients harboring H3.3-G34R high grade gliomas.

Published
2023

25. Analysis of donor pancreata defines the transcriptomic signature and microenvironment of early neoplastic lesions.

Author

Carpenter, Eileen S., primary, Elhossiny, Ahmed M., additional, Kadiyala, Padma, additional, Li, Jay, additional, McGue, Jake, additional, Griffith, Brian D., additional, Zhang, Yaqing, additional, Edwards, Jacob, additional, Nelson, Sarah, additional, Lima, Fatima, additional, Donahue, Katelyn L., additional, Du, Wenting, additional, Bischoff, Allison C., additional, Alomari, Danyah, additional, Watkoske, Hannah R., additional, Mattea, Michael, additional, The, Stephanie, additional, Espinoza, Carlos E., additional, Barrett, Meredith, additional, Sonnenday, Christopher J., additional, Olden, Nicholas, additional, Chen, Chin-Tung, additional, Peterson, Nicole, additional, Gunchick, Valerie, additional, Sahai, Vaibhav, additional, Rao, Arvind, additional, Bednar, Filip, additional, Shi, Jiaqi, additional, Frankel, Timothy L., additional, and Pasca di Magliano, Marina, additional

Published
2023
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26. Supplementary Figure 3 from Survival and Proliferation of Neural Progenitor–Derived Glioblastomas Under Hypoxic Stress is Controlled by a CXCL12/CXCR4 Autocrine-Positive Feedback Mechanism

Author

Calinescu, Anda-Alexandra, primary, Yadav, Viveka Nand, primary, Carballo, Erica, primary, Kadiyala, Padma, primary, Tran, Dustin, primary, Zamler, Daniel B., primary, Doherty, Robert, primary, Srikanth, Maithreyi, primary, Lowenstein, Pedro Ricardo, primary, and Castro, Maria Graciela, primary

Published
2023
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27. Supplementary Materials and Methods from Therapeutic Efficacy of Immune Stimulatory Thymidine Kinase and fms-like Tyrosine Kinase 3 Ligand (TK/Flt3L) Gene Therapy in a Mouse Model of High-Grade Brainstem Glioma

Author

Mendez, Flor, primary, Kadiyala, Padma, primary, Nunez, Felipe J., primary, Carney, Stephen, primary, Nunez, Fernando M., primary, Gauss, Jessica C., primary, Ravindran, Ramya, primary, Pawar, Sheeba, primary, Edwards, Marta, primary, Garcia-Fabiani, Maria Belen, primary, Haase, Santiago, primary, Lowenstein, Pedro R., primary, and Castro, Maria G., primary

Published
2023
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28. Supplementary Figure 1 from Survival and Proliferation of Neural Progenitor–Derived Glioblastomas Under Hypoxic Stress is Controlled by a CXCL12/CXCR4 Autocrine-Positive Feedback Mechanism

Author

Calinescu, Anda-Alexandra, primary, Yadav, Viveka Nand, primary, Carballo, Erica, primary, Kadiyala, Padma, primary, Tran, Dustin, primary, Zamler, Daniel B., primary, Doherty, Robert, primary, Srikanth, Maithreyi, primary, Lowenstein, Pedro Ricardo, primary, and Castro, Maria Graciela, primary

Published
2023
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29. Supplementary Figure 5 from Survival and Proliferation of Neural Progenitor–Derived Glioblastomas Under Hypoxic Stress is Controlled by a CXCL12/CXCR4 Autocrine-Positive Feedback Mechanism

Author

Calinescu, Anda-Alexandra, primary, Yadav, Viveka Nand, primary, Carballo, Erica, primary, Kadiyala, Padma, primary, Tran, Dustin, primary, Zamler, Daniel B., primary, Doherty, Robert, primary, Srikanth, Maithreyi, primary, Lowenstein, Pedro Ricardo, primary, and Castro, Maria Graciela, primary

Published
2023
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30. Supplementary Table 1 from Survival and Proliferation of Neural Progenitor–Derived Glioblastomas Under Hypoxic Stress is Controlled by a CXCL12/CXCR4 Autocrine-Positive Feedback Mechanism

Author

Calinescu, Anda-Alexandra, primary, Yadav, Viveka Nand, primary, Carballo, Erica, primary, Kadiyala, Padma, primary, Tran, Dustin, primary, Zamler, Daniel B., primary, Doherty, Robert, primary, Srikanth, Maithreyi, primary, Lowenstein, Pedro Ricardo, primary, and Castro, Maria Graciela, primary

Published
2023
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31. Supplementary Figure 2 from Survival and Proliferation of Neural Progenitor–Derived Glioblastomas Under Hypoxic Stress is Controlled by a CXCL12/CXCR4 Autocrine-Positive Feedback Mechanism

Author

Calinescu, Anda-Alexandra, primary, Yadav, Viveka Nand, primary, Carballo, Erica, primary, Kadiyala, Padma, primary, Tran, Dustin, primary, Zamler, Daniel B., primary, Doherty, Robert, primary, Srikanth, Maithreyi, primary, Lowenstein, Pedro Ricardo, primary, and Castro, Maria Graciela, primary

Published
2023
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32. Figure S8 from Therapeutic Efficacy of Immune Stimulatory Thymidine Kinase and fms-like Tyrosine Kinase 3 Ligand (TK/Flt3L) Gene Therapy in a Mouse Model of High-Grade Brainstem Glioma

Author

Mendez, Flor, primary, Kadiyala, Padma, primary, Nunez, Felipe J., primary, Carney, Stephen, primary, Nunez, Fernando M., primary, Gauss, Jessica C., primary, Ravindran, Ramya, primary, Pawar, Sheeba, primary, Edwards, Marta, primary, Garcia-Fabiani, Maria Belen, primary, Haase, Santiago, primary, Lowenstein, Pedro R., primary, and Castro, Maria G., primary

Published
2023
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33. Supplementary methods from Survival and Proliferation of Neural Progenitor–Derived Glioblastomas Under Hypoxic Stress is Controlled by a CXCL12/CXCR4 Autocrine-Positive Feedback Mechanism

Author

Calinescu, Anda-Alexandra, primary, Yadav, Viveka Nand, primary, Carballo, Erica, primary, Kadiyala, Padma, primary, Tran, Dustin, primary, Zamler, Daniel B., primary, Doherty, Robert, primary, Srikanth, Maithreyi, primary, Lowenstein, Pedro Ricardo, primary, and Castro, Maria Graciela, primary

Published
2023
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34. Supplementary Table 2 from Survival and Proliferation of Neural Progenitor–Derived Glioblastomas Under Hypoxic Stress is Controlled by a CXCL12/CXCR4 Autocrine-Positive Feedback Mechanism

Author

Calinescu, Anda-Alexandra, primary, Yadav, Viveka Nand, primary, Carballo, Erica, primary, Kadiyala, Padma, primary, Tran, Dustin, primary, Zamler, Daniel B., primary, Doherty, Robert, primary, Srikanth, Maithreyi, primary, Lowenstein, Pedro Ricardo, primary, and Castro, Maria Graciela, primary

Published
2023
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35. Table S1 from Therapeutic Efficacy of Immune Stimulatory Thymidine Kinase and fms-like Tyrosine Kinase 3 Ligand (TK/Flt3L) Gene Therapy in a Mouse Model of High-Grade Brainstem Glioma

Author

Mendez, Flor, primary, Kadiyala, Padma, primary, Nunez, Felipe J., primary, Carney, Stephen, primary, Nunez, Fernando M., primary, Gauss, Jessica C., primary, Ravindran, Ramya, primary, Pawar, Sheeba, primary, Edwards, Marta, primary, Garcia-Fabiani, Maria Belen, primary, Haase, Santiago, primary, Lowenstein, Pedro R., primary, and Castro, Maria G., primary

Published
2023
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36. Supplementary Figure 4 from Survival and Proliferation of Neural Progenitor–Derived Glioblastomas Under Hypoxic Stress is Controlled by a CXCL12/CXCR4 Autocrine-Positive Feedback Mechanism

Author

Calinescu, Anda-Alexandra, primary, Yadav, Viveka Nand, primary, Carballo, Erica, primary, Kadiyala, Padma, primary, Tran, Dustin, primary, Zamler, Daniel B., primary, Doherty, Robert, primary, Srikanth, Maithreyi, primary, Lowenstein, Pedro Ricardo, primary, and Castro, Maria Graciela, primary

Published
2023
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37. Supplementary figure legends from Survival and Proliferation of Neural Progenitor–Derived Glioblastomas Under Hypoxic Stress is Controlled by a CXCL12/CXCR4 Autocrine-Positive Feedback Mechanism

Author

Calinescu, Anda-Alexandra, primary, Yadav, Viveka Nand, primary, Carballo, Erica, primary, Kadiyala, Padma, primary, Tran, Dustin, primary, Zamler, Daniel B., primary, Doherty, Robert, primary, Srikanth, Maithreyi, primary, Lowenstein, Pedro Ricardo, primary, and Castro, Maria Graciela, primary

Published
2023
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38. Supplementary Figure 6 from Survival and Proliferation of Neural Progenitor–Derived Glioblastomas Under Hypoxic Stress is Controlled by a CXCL12/CXCR4 Autocrine-Positive Feedback Mechanism

Author

Calinescu, Anda-Alexandra, primary, Yadav, Viveka Nand, primary, Carballo, Erica, primary, Kadiyala, Padma, primary, Tran, Dustin, primary, Zamler, Daniel B., primary, Doherty, Robert, primary, Srikanth, Maithreyi, primary, Lowenstein, Pedro Ricardo, primary, and Castro, Maria Graciela, primary

Published
2023
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40. Arginase 1 is a key driver of immune suppression in pancreatic cancer

Author

Menjivar, Rosa E, primary, Nwosu, Zeribe C, additional, Du, Wenting, additional, Donahue, Katelyn L, additional, Hong, Hanna S, additional, Espinoza, Carlos, additional, Brown, Kristee, additional, Velez-Delgado, Ashley, additional, Yan, Wei, additional, Lima, Fatima, additional, Bischoff, Allison, additional, Kadiyala, Padma, additional, Salas-Escabillas, Daniel, additional, Crawford, Howard C, additional, Bednar, Filip, additional, Carpenter, Eileen, additional, Zhang, Yaqing, additional, Halbrook, Christopher J, additional, Lyssiotis, Costas A, additional, and Pasca di Magliano, Marina, additional

Published
2023
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42. Inhibition of 2-hydroxyglutarate elicits metabolic reprogramming and mutant IDH1 glioma immunity in mice

Author

Kadiyala, Padma, Carney, Stephen V., Gauss, Jessica C., Garcia-Fabiani, Maria B., Haase, Santiago, Alghamri, Mahmoud S., Nunez, Felipe J., Liu, Yayuan, Yu, Minzhi, Taher, Ayman, Nunez, Fernando M., Li, Dan, Edwards, Marta B., Kleer, Celina G., Appelman, Henry, Sun, Yilun, Zhao, Lili, Moon, James J., Schwendeman, Anna, Lowenstein, Pedro R., and Castro, Maria G.

Subjects
Gene mutations -- Health aspects, Gliomas -- Genetic aspects -- Development and progression -- Care and treatment, Oxidoreductases -- Health aspects, Health care industry
Abstract

Mutant isocitrate dehydrogenase 1 (IDH1-R132H; mIDH1) is a hallmark of adult gliomas. Lower grade mIDH1 gliomas are classified into 2 molecular subgroups: 1p/19q codeletion/TERT-promoter mutations or inactivating mutations in a-thalassemia/mental retardation syndrome X-linked (ATRX) and TP53. This work focuses on glioma subtypes harboring mIDH1, TP53, and ATRX inactivation. IDH1-R132H is a gain-of-function mutation that converts a-ketoglutarate into 2-hydroxyglutarate (D-2HG). The role of D-2HG within the tumor microenvironment of mIDH1/mATRX/mTP53 gliomas remains unexplored. Inhibition of D-2HG, when used as monotherapy or in combination with radiation and temozolomide (IR/TMZ), led to increased median survival (MS) of mIDH1 glioma-bearing mice. Also, D-2HG inhibition elicited anti- mIDH1 glioma immunological memory. In response to D-2HG inhibition, PD-L1 expression levels on mIDH1-glioma cells increased to similar levels as observed in WT-IDH gliomas. Thus, we combined D-2HG inhibition/IR/TMZ with anti-PDL1 immune checkpoint blockade and observed complete tumor regression in 60% of mIDH1 glioma-bearing mice. This combination strategy reduced T cell exhaustion and favored the generation of memory [CD8.sup.+] T cells. Our findings demonstrate that metabolic reprogramming elicits anti-mIDH1 glioma immunity, leading to increased MS and immunological memory. Our preclinical data support the testing of IDH-R132H inhibitors in combination with IR/TMZ and anti-PDL1 as targeted therapy for mIDH1/mATRX/mTP53 glioma patients., Introduction Gliomas are highly infiltrative brain tumors accounting for 32% of all primary central nervous system malignancies (1). With advances in molecular biology and sequencing technologies, a distinct profile of [...]

Published
2021
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43. Analysis of donor pancreata defines the transcriptomic signature and microenvironment of early pre-neoplastic pancreatic lesions

Author

Carpenter, Eileen S., primary, Elhossiny, Ahmed M., additional, Kadiyala, Padma, additional, Li, Jay, additional, McGue, Jake, additional, Griffith, Brian, additional, Zhang, Yaqing, additional, Edwards, Jacob, additional, Nelson, Sarah, additional, Lima, Fatima, additional, Donahue, Katelyn L., additional, Du, Wenting, additional, Bischoff, Allison C., additional, Alomari, Danyah, additional, Watkoske, Hannah, additional, Mattea, Michael, additional, The, Stephanie, additional, Espinoza, Carlos, additional, Barrett, Meredith, additional, Sonnenday, Christopher J., additional, Olden, Nicholas, additional, Peterson, Nicole, additional, Gunchick, Valerie, additional, Sahai, Vaibhav, additional, Rao, Arvind, additional, Bednar, Filip, additional, Shi, Jiaqi, additional, Frankel, Timothy L., additional, and Di Magliano, Marina Pasca, additional

Published
2023
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44. Author response: Arginase 1 is a key driver of immune suppression in pancreatic cancer

Author

Menjivar, Rosa E, primary, Nwosu, Zeribe C, additional, Du, Wenting, additional, Donahue, Katelyn L, additional, Hong, Hanna S, additional, Espinoza, Carlos, additional, Brown, Kristee, additional, Velez-Delgado, Ashley, additional, Yan, Wei, additional, Lima, Fatima, additional, Bischoff, Allison, additional, Kadiyala, Padma, additional, Salas-Escabillas, Daniel, additional, Crawford, Howard C, additional, Bednar, Filip, additional, Carpenter, Eileen, additional, Zhang, Yaqing, additional, Halbrook, Christopher J, additional, Lyssiotis, Costas A, additional, and Pasca di Magliano, Marina, additional

Published
2022
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46. Abstract PR021: CCR1 expression defines pancreatic tumor associated macrophages and drives their immunosuppressive properties

Author

Zhang, Yaqing, primary, Yan, Wei, additional, Brown, Kristee L., additional, Velez-Delgado, Ashely, additional, Nwosu, Zeribe C., additional, Donahue, Katelyn, additional, Kadiyala, Padma, additional, Yang, Sion, additional, Avritt, Faith R., additional, He, Xi, additional, Espinoza, Carlos, additional, and di Magliano, Marina Pasca, additional

Published
2022
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47. Abstract C062: Investigating the role of pancreatic intraepithelial neoplasia in development of pancreatic ductal adenocarcinoma

Author

Kadiyala, Padma, primary, Carpenter, Eileen, additional, Elhossiny, Ahmed, additional, Zhang, Yaqing, additional, Nelson, Sarah, additional, Lima, Fatima, additional, Donahue, Katelyn, additional, Du, Wenting, additional, McGue, Jake, additional, Watkoske, Hannah, additional, Attebury, Holly, additional, Daley, Donnele, additional, Bednar, Filip, additional, Rao, Arvind, additional, Frankel, Timothy, additional, and Di Magliano, Marina Pasca, additional

Published
2022
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49. H3.3-G34 mutations impair DNA repair and promote cGAS/STING-mediated immune responses in pediatric high-grade glioma models

Author

Haase, Santiago, primary, Banerjee, Kaushik, additional, Mujeeb, Anzar A., additional, Hartlage, Carson S., additional, Núñez, Fernando M., additional, Núñez, Felipe J., additional, Alghamri, Mahmoud S., additional, Kadiyala, Padma, additional, Carney, Stephen, additional, Barissi, Marcus N., additional, Taher, Ayman W., additional, Brumley, Emily K., additional, Thompson, Sarah, additional, Dreyer, Justin T., additional, Alindogan, Caitlin T., additional, Garcia-Fabiani, Maria B., additional, Comba, Andrea, additional, Venneti, Sriram, additional, Ravikumar, Visweswaran, additional, Koschmann, Carl, additional, Carcaboso, Ángel M., additional, Vinci, Maria, additional, Rao, Arvind, additional, Yu, Jennifer S., additional, Lowenstein, Pedro R., additional, and Castro, Maria G., additional

Published
2022
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50. WNT signaling in the tumor microenvironment promotes immunosuppression in murine pancreatic cancer

Author

Du, Wenting, primary, Menjivar, Rosa E., additional, Donahue, Katelyn L., additional, Kadiyala, Padma, additional, Velez-Delgado, Ashley, additional, Brown, Kristee L., additional, Watkoske, Hannah R., additional, He, Xi, additional, Carpenter, Eileen S., additional, Angeles, Christina V., additional, Zhang, Yaqing, additional, and Pasca di Magliano, Marina, additional

Published
2022
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