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295 results on '"Jin, Yanping"'

4. Development of Partition-Designed Outdoor Workwear with Optimal Fabric Selection.

Author

Li, Hongyan, Mo, Yu, Dong, Guanliang, Jin, Yanping, Zhang, Dan, Li, Jian, and Chen, Tao

Subjects
WORK clothes, PHYSIOLOGICAL effects of heat, OUTDOOR clothing, ERGONOMICS, TEXTILES
Abstract

The necessity for anti-heat stress workwear to ensure the safety and performance of outdoor workers in hot, humid environments is clear. Yet, there is a gap in fabric selection techniques that consider multi-criteria decisions and account for the varying functional needs across different body regions. Here, we proposed a hybrid multi-criteria decision-making approach, merging the efficacy coefficient method, analytic hierarchy process, entropy weight, and technique of order preference by similarity to the ideal solution for developing ergonomic modular outdoor workwear. This method is tailored for anti-heat stress workwear, balancing competing functional demands. Initial research involved surveying workwear requirements in terms of human, clothing, and environmental factors, leading to the selection and testing of 15 fabrics for 6 partitioned designs. We established data standardization by the efficacy coefficient method and six evaluation index systems for human body requirements, with analytic hierarchy process and entropy methods determining subjective and objective criteria weights. The technique of order preference by similarity was used to produce the ideal solution then ranking of pre-screened fabrics, culminating in the optimal selection. For validation, three uniform prototypes were developed and tested through sweating manikin experiments and human wear trials to affirm the effectiveness of our approach. The partitioned design method proved more effective for anti-heat stress workwear for outdoor workers compared to existing solutions. [ABSTRACT FROM AUTHOR]

Published
2024
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5. Bioinformatics Analysis of Stem Cell circ-ASB3 Signaling Pathway and Its Affection on Glioma Biological Characteristics

Author

Li Guowei and Jin Yanping

Subjects
circRNA, bioinformatics analysis, axis, malignancy, glioma stem cell (GSC), Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571
Abstract

ObjectiveIn our research we try to explore whether glioma stem cell containing circRNAs signal pathway could regulate glioma malignant progression and elaborate its possible mechanism.MethodsIn this study, we used biological information analysis to build an RNA regulatory network and then proceeded RT-PCR to screen target RNAs, after that we clarified the targeting relationship between circRNA-miRNA-mRNA through double luciferase gene assay, RNA pull down experiment, PCR and Western Blot. Finally we adopted RNA transfection to identify its impact on glioma cell proliferation, invasion, migration, apoptosis and cell cycle.Resultscirc-ASB3 was significantly up-regulated in glioma stem cells compared with glioma cells. The circ-ASB3/miR-543/Twist1 axis was discovered to be a possible regulatory pathway in glioma, circ-ASB3 could adsorb and targeted bind to miR-543, down-regulate miR-543 expression, thus release its targeted inhibition to Twist1. Circ-ASB3 was shown to increase glioma cell proliferation, invasion, and migration in vitro via miR-543/Twist1 axis. Meanwhile glioma cell apoptosis could be inhibited, and cell cycle arrest could be induced through this signaling pathway.Conclusioncirc-ASB3 could enhance glioma malignancy via miR-543/Twist1 axis, resulting in the discovery of new biomarkers and possible therapeutic targets for these patients.

Published
2022
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