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Abstract Using live feed in fish larviculture is more expensive and challenging than formulated feeds, incentivizing the early weaning of larvae. In New Zealand, the aquaculture of larval giant kōkopu, Galaxias argenteus, is being commercialized because of its high value and to supplement the wild fishery. As an emerging aquaculture species, inefficiencies remain in the production process, inhibiting financial viability. This study reports on the ability of these larvae to consume formulated larval diets across four ages (18, 21, 25, and 28 days after hatching, DAH) at each of the three daily feeding events (Morning, Midday, and Afternoon) during commercial production. At 18 DAH, little to no formulated feed was consumed at either of the three feeding events throughout the day. At 21 DAH, mean gut fullness increased and the number of fish with empty stomachs reduced by the end of the Morning and Afternoon feeding events. Both variables improved further for larvae at 25 and 28 DAH. Formulated feed consumption did not differ between larvae aged 25 and 28 DAH indicating that 3 days of feeding live feed could be removed from the feed regime. This change would save 13% on the cost of live feed; however, further research is required to determine the potential impacts on growth and survival.

Today's Information Systems (IS) design research projects pursue digital innovation to conquer complex societal challenges. Many of these projects reach out beyond disciplinary and organisational boundaries, as evident in interdisciplinary consortia and academia‐industry collaboration. The design activities in each project differ based on contextual requirements and the team's underlying design logic. As diversity increases, shared understanding is essential for project success. Established design research methodologies need complementary tools to support design researchers in configuring their design activities and representing them faithfully, dimensions that contribute to a shared understanding. This article presents Baustein as an instance of such design tools. Baustein is tailorable to the contextual requirements of each design research project, comprising an ensemble of card‐deck, ready‐made configurations, and a manual. To ensure theoretical and practical relevance, the design of Baustein is based on primary empirical data (workshop and interviews with 16 IS design researchers) and a literature analysis of 99 published IS design research projects. We demonstrate its proof‐of‐value through three main evaluation episodes, altogether involving over 110 IS design researchers. With Baustein, design research teams can balance the trade‐off between creative messiness and standardised configurations of design activities. [ABSTRACT FROM AUTHOR]

Crop genomes accumulate deleterious mutations-a phenomenon known as the cost of domestication. Precision genome editing has been proposed to eliminate such potentially harmful mutations; however, experimental demonstration is lacking. Here we identified a deleterious mutation in the tomato transcription factor SUPPRESSOR OF SP2 (SSP2), which became prevalent in the domesticated germplasm and diminished DNA binding to genome-wide targets. We found that the action of SSP2 is partially redundant with that of its paralog SSP in regulating shoot and inflorescence architecture. However, redundancy was compromised during tomato domestication and lost completely in the closely related species Physalis grisea, in which a single ortholog regulates shoot branching. We applied base editing to directly repair the deleterious mutation in cultivated tomato and obtained plants with compact growth that provide an early fruit yield. Our work shows how deleterious variants have sensitized modern genotypes for phenotypic tuning and illustrates how repairing deleterious mutations with genome editing may allow predictable crop improvement., Competing Interests: Competing interests: The authors declare no competing interests., (© 2025. The Author(s), under exclusive licence to Springer Nature America, Inc.)

Large scale -omics datasets can provide new insights into normal and diseaserelated biology when analyzed through a systems biology framework. However, technical artefacts present in most -omics datasets due to variations in sample preparation, batching, platform settings, personnel, and other experimental procedures prevent useful analyses of such data without prior adjustment for these technical factors. Here, we demonstrate a tunable median polish of ratio (TAMPOR) approach for batch effect correction and agglomeration of multiple, multi-batch, site-specific cohorts into a single analyte abundance data matrix that is suitable for systems biology analyses. We illustrate the utility and versatility of TAMPOR through four distinct use cases where the method has been applied to different proteomic datasets, some of which contain a specific defect that must be addressed prior to analysis. We compare quality control metrics and sources of variance before and after application of TAMPOR to show that TAMPOR is effective at removing batch effects and other unwanted sources of variance in -omics data. We also show how TAMPOR can be used to harmonize -omics datasets even when the data are acquired using different analytical approaches. TAMPOR is a powerful and flexible approach for cleaning and harmonization of -omics data prior to downstream systems biology analysis. [ABSTRACT FROM AUTHOR]

The lunar surface evolves over time due to space weathering, and the visible–near‐infrared spectra of more mature (i.e., heavily weathered) soils are lower in reflectance and steeper in spectral slope (i.e., darker and redder) than their immature counterparts. These spectral changes have traditionally been attributed to the space‐weathered rims of soil grains (and particularly nanophase iron therein). However, understudied thus far is the spectral role of agglutinates—the agglomerates of mineral and lithic fragments, nanophase iron, and glass that are formed by micrometeoroid impacts and are ubiquitous in mature lunar soils. We separated agglutinates and non‐agglutinates from six lunar soils of varying maturity and composition, primarily from the 125–250 μm size fraction, and measured their visible–near‐infrared reflectance spectra. For each soil, the agglutinate spectra are darker, redder, and have weaker absorption bands than the corresponding non‐agglutinate and unsorted soil spectra. Moreover, greater soil maturity corresponds to darker agglutinate spectra with weaker absorption bands. These findings suggest that agglutinates (rather than solely the space‐weathered rims) play an important role in both the darkening and reddening of mature soils—at least for the size fractions examined here. Comparisons with analog soils suggest that high nanophase iron abundance in agglutinates is likely responsible for their low reflectance and spectrally red slope. Additional studies of agglutinates are needed both to more comprehensively characterize their spectral properties (across size fractions and in mixing with non‐agglutinates) and to assess the relative roles of agglutinates and rims in weathering‐associated spectral changes. Plain Language Summary: In the scientific study of the Moon, one key focus is surface processes: how do the physical and chemical properties of the Moon's surface change over time due to weathering (e.g., bombardment by micrometeoroids and by particles from the Sun)? Such investigations provide valuable insights into the Moon's history (such as the ages of impact craters) that are often deduced from measurements of reflected light; as a soil is weathered, it reflects light differently, which manifests visually as a progressive darkening of the soil. This phenomenon had primarily been attributed to weathering‐associated development of rims on individual soil grains, but in this work we explored an alternative cause: soil particles known as agglutinates (misshapen, vesicular agglomerates of mineral fragments, iron, and glass that form due to weathering processes). We isolated agglutinates of six soil samples from the Moon and measured how they reflect light. We find that they reflect light in patterns reminiscent of how the Moon's surface behaves when weathered. These findings suggest that agglutinates play a more important role than previously thought in determining the light‐reflecting properties of the Moon's surface, thus warranting a greater and more nuanced consideration in future studies of how the Moon's surface changes over time. Key Points: We measured the reflectance spectra of agglutinates and non‐agglutinates separated from six lunar soils of varying composition and maturitySpectral comparisons suggest that spectral reddening of mature soils is expressed mainly via agglutinates (for the size fractions measured)These findings reframe our understanding of the relative spectral roles of agglutinates and soil grain rims in weathered lunar soils [ABSTRACT FROM AUTHOR]

Increasing scientific and regulatory concern regarding environmental concentrations of bisphenol A (BPA) increases the need to understand the sources and sinks of this chemical. We developed a coupled flow network/fugacity‐based fate and transport model to assess the contribution of different emissions sources to the concentration of BPA in surface water in Germany. The model utilizes BPA loadings and sinks, BPA physicochemical properties, a water flow network, environmental characteristics, and fugacity equations. The model considers industrial emissions, leaching from BPA‐containing articles, wastewater treatment and bypass events, and emissions from landfills. The model also considers different scenarios that account for changes in the usage profile of BPA. Model predictions compare favorably to measured surface water concentrations, with the modeled concentrations generally falling within the range of measured values. Model scenarios that consider reductions in BPA usage due to government‐mandated restrictions and voluntary reductions in usage predict falling BPA concentrations that are consistent with the most recent monitoring data. Model predictions of the contributions from different usage scenarios and wastewater treatment methods can be used to assess the efficacy of different restrictions and waste handling strategies to support efforts to evaluate the costs and benefits associated with actions aimed at reducing BPA levels in the environment. This feature of the model is of particular importance, given current efforts to update the regulations regarding BPA usage in the EU. The model indicates that as the current restriction on BPA in thermal paper works through the paper recycling process, BPA concentrations will continue to decrease. Other actions, such as upgrades to the stormwater and wastewater infrastructure to minimize the frequency of storm‐related bypasses, are predicted to provide more meaningful reductions than additional restrictions on usage. Integr Environ Assess Manag 2024;20:226–238. © 2023 The Authors. Integrated Environmental Assessment and Management published by Wiley Periodicals LLC on behalf of Society of Environmental Toxicology & Chemistry (SETAC). Key Points: We used a coupled fugacity‐based model and flow network to model BPA in surface waters of Germany that considered different scenarios representative of current and future BPA usage.There was good agreement between the measured and modeled concentrations, and the model predicted the observed reduction in surface water concentrations associated with recent usage restrictions.The model predicts that improved management of landfills and landfill leachate and improvements in stormwater infrastructure can result in significant reductions in loadings and therefore further reductions in surface water BPA concentrations. [ABSTRACT FROM AUTHOR]

This study investigated circumstances surrounding the impact of COVID-19 on child protection investigations, particularly those affecting newcomer parents in Ontario, Canada. Recognizing that the pandemic inflicted substantial socioeconomic disadvantage on some people, the purpose of the study was to use an intersectional lens to examine challenges and solutions found by child welfare agencies when working with families. Insights for policy and practice are drawn from 11 virtual interviews with child welfare workers and managers in Ontario. Our findings reveal that some newcomer families encountered unique challenges: ineligibility for the available pandemic public assistance; inaccessibility to faith-based supports, which had often been their first key contact for mental wellness in the past; technological inequities; and language barriers. These intersecting conditions impacted newcomer families and led to innovative child protection interventions. Analysis of the interview data shows a gradual shift in Ontario from risk-focused approaches to supportive and preventative child welfare interventions in families. Furthermore, supervisors faced the dilemma of how stringently to enforce ongoing safety policies when some social workers were questioning the benefits of these rules for families with intersecting identities who were experiencing added burdens because of the pandemic. [ABSTRACT FROM AUTHOR]

With the emergent focus on human-centered artificial intelligence (HCAI), research is required to understand the humanistic aspects of AI design, identify the mechanisms through which user concerns may be alleviated, thereby positively influencing AI adoption. To fill this void, we introduce "Situation Awareness" (SA) as a conceptual framework for considering human-AI interaction (HAII). We argue that SA is an appropriate and valuable theoretical lens through which to decompose and view HAII as hierarchical layers that allow for closer inquiry and discovery. Furthermore, we illustrate why the SA perspective is particularly relevant to the current need to understand HCAI by identifying three tensions inherent in AI design and explaining how an SA-oriented approach may help alleviate these tensions. We posit that users' enactment of SA will mitigate some negative impacts of AI systems on user experience, improve human agency during AI system use, and promote more efficient and effective in-situ decision-making. [ABSTRACT FROM AUTHOR]

Using live feed in fish larviculture is more expensive and challenging than formulated feeds, incentivizing the early weaning of larvae. In New Zealand, the aquaculture of larval giant kōkopu, Galaxias argenteus, is being commercialized because of its high value and to supplement the wild fishery. As an emerging aquaculture species, inefficiencies remain in the production process, inhibiting financial viability. This study reports on the ability of these larvae to consume formulated larval diets across four ages (18, 21, 25, and 28 days after hatching, DAH) at each of the three daily feeding events (Morning, Midday, and Afternoon) during commercial production. At 18 DAH, little to no formulated feed was consumed at either of the three feeding events throughout the day. At 21 DAH, mean gut fullness increased and the number of fish with empty stomachs reduced by the end of the Morning and Afternoon feeding events. Both variables improved further for larvae at 25 and 28 DAH. Formulated feed consumption did not differ between larvae aged 25 and 28 DAH indicating that 3 days of feeding live feed could be removed from the feed regime. This change would save 13% on the cost of live feed; however, further research is required to determine the potential impacts on growth and survival. [ABSTRACT FROM AUTHOR]

ZnO was impregnated with Ni in order to increase its photocatalytic performance in the visible region. The Ni-impregnated ZnO catalyst was synthesized by wet impregnation. The synthesis of Ni/ZnO catalyst, its morphological analysis and elemental analysis was confirmed by X-ray diffraction (XRD), scanning electron microscopy (SEM), and energy dispersive X-ray (EDX) spectroscopy which confirmed that 4.66% Ni was impregnated at the surface of ZnO. The synthesized catalyst was applied for the photocatalytic degradation of Remazol Brilliant Violet-5R (RBV-5R) and methyl orange (MO) in aqueous solution. The catalyst dosage, pH, dye concentration, and effect of scavengers were optimized. 98.92% degradation of RBV-5R was observed at pH 10 using 0.1 g of catalyst, 5 mmol H2O2 in 20 min, whereas 83.77% MO was degraded using 0.2 g of the catalyst at pH 4 in 30 min. The order of reaction was also determined by applying kinetic models and the degradation followed pseudo first-order kinetics for both dyes. [ABSTRACT FROM AUTHOR]

Large scale -omics datasets can provide new insights into normal and diseaserelated biology when analyzed through a systems biology framework. However, technical artefacts present in most -omics datasets due to variations in sample preparation, batching, platform settings, personnel, and other experimental procedures prevent useful analyses of such data without prior adjustment for these technical factors. Here, we demonstrate a tunable median polish of ratio (TAMPOR) approach for batch effect correction and agglomeration of multiple, multi-batch, site-specific cohorts into a single analyte abundance data matrix that is suitable for systems biology analyses. We illustrate the utility and versatility of TAMPOR through four distinct use cases where the method has been applied to different proteomic datasets, some of which contain a specific defect that must be addressed prior to analysis. We compare quality control metrics and sources of variance before and after application of TAMPOR to show that TAMPOR is effective at removing batch effects and other unwanted sources of variance in -omics data. We also show how TAMPOR can be used to harmonize -omics datasets even when the data are acquired using different analytical approaches. TAMPOR is a powerful and flexible approach for cleaning and harmonization of -omics data prior to downstream systems biology analysis. [ABSTRACT FROM AUTHOR]

We used laboratory analysis to investigate the effect of mineral albedo, as defined at 750 nm, on the midinfrared emissivity spectra of silicates under lunar environment conditions. Optical darkening has long been recognized as an effect of space weathering on the visible‐to‐near‐infrared spectra of the Moon. However, space weathering has not been as thoroughly investigated in the mid‐infrared. Because mid‐infrared spectra are strongly influenced by the anisothermality of the lunar surface environment, it is likely that any darkening effects of space weathering would also change the thermal gradient in heavily space weathered lunar regolith. To isolate this variable, we added nanophase carbon to particulate samples of forsterite, augite, and anorthite to achieve a range of albedo samples and measured their midinfrared spectra under lunar environment conditions within the Planetary and Asteroid Regolith Spectroscopy Environment Chamber at Stony Brook University. We observe a shift in the Christiansen Feature maximum to longer wavelengths and decreasing spectral contrast with decreasing albedo. These shifts are well correlated with the observation of space weathering effects on the Diviner Lunar Radiometer Experiment compositional data, and point to the need for further investigation into the effects of space weathering on the midinfrared spectra of airless bodies. Plain Language Summary: Space weathering is a major process on the Moon that matures lunar soils over time. In this work, we try to isolate one of the effects of space weathering, darkening, to determine its effects on our interpretation of midinfrared emissivity spectra. We do so by adding nano‐scale carbon particles to three silicate minerals and examine how the spectral features change as the sample gets darker under both ambient and simulated lunar environment conditions. We observe a decrease in overall spectral contrast and a shift in the Christiansen Feature (CF) position to longer wavelengths with increasing carbon content. This correlation between the darkening sample and CF value is similarly observed in the remote sensing data from Diviner Lunar Radiometer Experiment and Kaguya Multiband Imager instruments, demonstrating that it is an important factor to consider to accurately interpret composition from mid‐infrared data of space weathered soils on airless bodies. Key Points: Space weathering affects midinfrared data from the Moon largely by altering regolith albedoAlbedo affects the position of the Christiansen feature (CF) of minerals in the midinfrared under ambient and simulated lunar environment conditionsCorrelation between albedo and CF is shown in remote sensing data and laboratory experiments [ABSTRACT FROM AUTHOR]

Exceptionally high rates of partner violence perpetration are evident among men returning from prison. Two bodies of scholarship, one on family stress and another on exposure to state violence, each suggest that criminal legal system exposure could promote partner violence perpetration via changes in men's behavioral health and interpersonal approach and in couples' conflict dynamics. Such relationships have not been tested in quantitative research. Structural equation models were fitted to longitudinal, couples-based survey data from the Multi-site Family Study on Incarceration, Parenting, and Partnering. Participants included men returning from a state prison term in five U.S. states (N = 1112) and their committed intimate or co-parenting partners (N = 1112). Models tested hypothesized pathways from three dimensions of criminal legal system exposure to later partner violence perpetration. In fitted models, men's childhood criminal legal system exposure predicts their post-prison partner violence perpetration via adult post-traumatic stress symptoms, reactivity, avoidance, and dysfunctional couple conflict dynamics. Men's cumulative criminal legal system exposure in adulthood predicts their post-prison partner violence perpetration via addiction and dysfunctional couple conflict. These initial results suggest that mass-scale incarceration could worsen partner violence via men's psychological and interpersonal adaptations to criminal legal system contact, particularly when such contact is sustained or occurs at a developmentally significant period in the life course. [ABSTRACT FROM AUTHOR]

Asexual reproduction through seeds in plants (i.e., apomixis) is a heritable trait, and apomixis- linked loci have been identified in multiple species. However, direct identification of genomic elements is typically hindered as apomixis-linked loci and are commonly found in recombination-suppressed and repetitive regions. Heterochromatinized elements, such as B chromosomes and other supernumerary chromosomal DNA fragments have long been known to be associated with asexuality in both plants and animals and are prime candidate regions for the evolution of multiple apomixis factors controlling the individual elements of apomixis. Here, we examined molecular evolution, gene regulation, and chromosomal location of a male apomeiosis factor (UPG2), a long noncoding RNA gene, in sexual and apomictic Boechera with and without male apomeiosis (i.e., balanced and unbalanced apomicts). We revealed the origin of the gene in the apomixis genome on an apomixis-specific, supernumerary heterochromatic Boechera chromosome (Boe1). The UPG2 is active in the tapetum at male meiosis. We found allele classes specific to apomictic and sexual Boechera accessions and a third class that shares the features of both and points to a convergent transition state. Sex alleles are found only in some of the sexual accessions and have higher nucleotide divergence and lower transcriptional activity compared to apo alleles. These data demonstrate selective pressure to maintain the function of UPG2 for unreduced pollen formation in apomicts as the occasional transmission of the allele from unbalanced apomicts into sexual organisms that lead to pseudogenization and functional decay of copies in sexual organisms. [ABSTRACT FROM AUTHOR]

Nonsense mutations are a type of mutations which results in a premature termination codon occurrence. In general, these mutations have been considered to be among the most harmful ones which lead to premature protein translation termination and result in shortened nonfunctional polypeptide. However, there is evidence that not all nonsense mutations are harmful as well as some molecular mechanisms exist which allow to avoid pathogenic effects of these mutations. This review addresses relevant information on nonsense mutations in eukaryotic genomes, characteristics of these mutations, and different molecular mechanisms preventing or mitigating harmful effects thereof. [ABSTRACT FROM AUTHOR]

Selection leaves signatures in the DNA sequence of genes, with many test statistics devised to detect its action. While these statistics are frequently used to support hypotheses about the adaptive significance of particular genes, the effect these genes have on reproductive fitness is rarely quantified experimentally. Consequently, it is unclear how gene‐level signatures of selection are associated with empirical estimates of gene effect on fitness. Eukaryotic data sets that permit this comparison are very limited. Using the model plant Arabidopsis thaliana, for which these resources are available, we calculated seven gene‐level substitution and polymorphism‐based statistics commonly used to infer selection (dN/dS, NI, DOS, Tajima's D, Fu and Li's D*, Fay and Wu's H, and Zeng's E) and, using knockout lines, compared these to gene‐level estimates of effect on fitness. We found that consistent with expectations, essential genes were more likely to be classified as negatively selected. By contrast, using 379 Arabidopsis genes for which data was available, we found no evidence that genes predicted to be positively selected had a significantly different effect on fitness than genes evolving more neutrally. We discuss these results in the context of the analytic challenges posed by Arabidopsis, one of the only systems in which this study could be conducted, and advocate for examination in additional systems. These results are relevant to the evaluation of genome‐wide studies across species where experimental fitness data is unavailable, as well as highlighting an increasing need for the latter. [ABSTRACT FROM AUTHOR]

Parasitic plants have evolved to be subtly or severely dependent on host plants to complete their life cycle. To provide new insights into the biology of parasitic plants in general, we assembled genomes for members of the sandalwood order Santalales, including a stem hemiparasite (Scurrula) and two highly modified root holoparasites (Balanophora) that possess chimaeric host-parasite tubers. Comprehensive genome comparisons reveal that hemiparasitic Scurrula has experienced a relatively minor degree of gene loss compared with autotrophic plants, consistent with its moderate degree of parasitism. Nonetheless, patterns of gene loss appear to be substantially divergent across distantly related lineages of hemiparasites. In contrast, Balanophora has experienced substantial gene loss for the same sets of genes as an independently evolved holoparasite lineage, the endoparasitic Sapria (Malpighiales), and the two holoparasite lineages experienced convergent contraction of large gene families through loss of paralogues. This unprecedented convergence supports the idea that despite their extreme and strikingly divergent life histories and morphology, the evolution of these and other holoparasitic lineages can be shaped by highly predictable modes of genome reduction. We observe substantial evidence of relaxed selection in retained genes for both hemi- and holoparasitic species. Transcriptome data also document unusual and novel interactions between Balanophora and host plants at the host-parasite tuber interface tissues, with evidence of mRNA exchange, substantial and active hormone exchange and immune responses in parasite and host., (© 2023. The Author(s), under exclusive licence to Springer Nature Limited.)

Background. Diabetes mellitus (DM) is a prognostic marker in elderly patients with cardiovascular diseases, but its predictive value in elderly valvular heart disease (VHD) patients is unclear. This study aimed to investigate the effect of DM on the long-term outcome of elderly VHD patients. Methods. This single-center, observational study enrolled patients aged 65 and older consecutively with confirmed VHD using echocardiography. Patients, divided into the DM group and non-DM group, were followed up for major adverse cardiac and cerebrovascular events (MACCEs), including all-cause death, ischemic stroke, and heart failure rehospitalization. Results. Our study consisted of 532 patients over a median follow-up of 52.9 months. Compared with the non-DM group (n = 377), the DM group (n = 155) had higher incidences of ischemic stroke (25.2% vs. 13.5%, P = 0.001), heart failure rehospitalization (37.4% vs. 20.7%, P < 0.001), and MACCEs (60.0% vs. 35.8%, P < 0.001). After adjustment of confounders by the multivariable cox regression, DM appeared as an independent predictor for MACCEs (adjusted hazard ratio, aHR: 1.88; 95% confidence interval 1.42–2.48; P < 0.001). In the subgroup analysis of VHD etiology and functional style, conversely, DM was a protective factor for MACCEs in the patients with rheumatic VHD compared with those without rheumatic VHD (aHR: 0.43 vs. 2.27, P = 0.004). Conclusions. DM was an independent predictor for ischemic stroke and heart failure rehospitalization in elderly VHD patients undergoing conservative treatment. [ABSTRACT FROM AUTHOR]

The seeding of small juvenile green‐lipped mussels (Perna canaliculus) onto coastal farms is associated with high losses. These losses can be reduced by seeding larger juveniles; however, the nursery culture of juveniles is unviable because of the high cost of producing live microalgal feeds. In this study, we compared the ability for two diets, a formulated microparticulate feed, MySpat and liposomes fabricated with mussel extract to replace live microalgae at different proportions for feeding small (1.9 mm shell length ±0.02 SE) green‐lipped mussels. The experimental diets consisted of a mix of live Tisochrysis lutea, Diacronema lutheri and Chaetoceros muelleri that were replaced with increasing proportions of MySpat (25%, 50% and 75%), and liposomes (25% and 50%). There were no significant differences in mortality of mussels relative to the control (100% microalgae) among any of the diet treatments. However, mussel growth tended to decrease with increasing substitution of the microalgal component of the diets. The results from this study suggest that microparticulate and liposome formats provide a viable mode of food delivery to juvenile mussels, with improved formulation of these formats having the potential to lead to the substitution of live microalgal diets which make nursery culture unviable at present. [ABSTRACT FROM AUTHOR]

To understand the yield response of cereal cultivars to Pratylenchus thornei, eight experiments were conducted within the subtropical northern, and temperate southern grain‐producing regions of Australia. Wheat cultivars (Triticum aestivum) ranging from susceptible to moderately resistant to P. thornei were grown in Year 1 to establish a range of population densities. In Year 2 before sowing, P. thornei was quantified in each plot and six cereal cultivars were each grown on a similar range of population densities (average minimum to maximum of 3.4–60.6 P. thornei/g soil); P. thornei was quantified again at harvest. In the four experiments in the northern region there was a significant, negative logarithmic response of yield of the three most intolerant/susceptible cultivars as P. thornei population densities increased (yield decreased 172–479 kg/ha per unit increase in loge‐transformed P. thornei/g soil). The responsiveness of yield to increasing P. thornei population densities diminished as the tolerance and resistance of the cultivars improved. In the southern region, there was no relationship between yield and P. thornei in three experiments and minor, positive increases in one experiment (1.6 kg/ha per unit increase in P. thornei/g soil). Across both regions, the change in P. thornei population densities from sowing to harvest was logarithmic and positive, and generally greatest in the northern region. The contrast of responses of cereal cultivars between the regions, despite similar population densities of P. thornei, is indicative of the influence of the environment particularly on tolerance, therefore management with a regional focus is essential. [ABSTRACT FROM AUTHOR]

This paper proposes an integrated research framework that takes advantage of the similarities of design science research (DSR) and Design-based research (DBR) for developing a new decision support system (DSS) artefact. Firstly, the paper discusses the progression of DSR in the Information Systems and evolution of DBR in educational technology notifying the similarities and limitations. Next, we apply our proposed framework combining DSR and DBR to develop and effectively evaluate the artefact of the Educational DSS that can be used to identify students at risk and improve student retention and completion rate. Further, our paper creates a basis of methodological guide to construct and evaluate a machine learning (ML) based DSS artefact by conformity to the features and tenets of commonalities between DSR and DBR and correlating them to Peffer's design science research approach. In line with the characteristic of DSR and DBR, the development framework that we proposed will be used as a new source of knowledge to design any IT artefact in the education domain. [ABSTRACT FROM AUTHOR]

Maps of plagioclase, olivine, and pyroxene at 1 km resolution are derived from a combination of data from the Diviner Lunar Radiometer on the Lunar Reconnaissance Orbiter and the Kaguya Multiband Imager. The Diviner instrument features three infrared bands designed to characterize a spectral feature of lunar soils that is sensitive to the average silica polymerization of the surface called the Christiansen Feature, which is directly sensitive to the presence of plagioclase, the dominant lunar silicate. Existing global mineral maps based on near‐IR data largely infer the presence of plagioclase from the bright mineral's effect on total reflectance, excepting in rare locations where the surface is nearly pure plagioclase and a weak feature in the plagioclase near‐IR spectrum can be relied upon. By integrating both wavelength regions we produced more robust estimates of the abundance of the three dominant minerals. In the process of this work, we also improved the removal of space weathering effects from Christiansen Feature maps, and showed that silica rich compositional anomalies could be reliably detected by decorrelating Christiansen Feature and FeO maps. New silica‐rich locations are reported as are the global abundances of the three major silicates. Plain Language Summary: One of the goals of remote sensing of the Moon is to produce maps of the minerals present on its surface. In this paper, we bring together two infrared spectroscopic data sets to create maps of the minerals plagioclase, pyroxene, and olivine at a resolution of 1 km. One of these infrared data sets defines the wavelength position of a spectral phenomenon called the Christiansen Feature that is sensitive to the presence of unusual silica‐rich minerals that indicate a relatively rare but widespread style of lunar volcanism. Using these new data, we find a few previously unrecognized silica‐rich exposures that extend the spatial range of these features. The Christiansen Feature is also sensitive to rare rock types that may represent outcrops of the lunar mantle at the surface of the Moon, and a promising candidate is revealed at the farside crater Titov. Key Points: The global abundance of plagioclase, pyroxene and olivine are presentedThe effects of space weathering on Christiansen Feature maps are removed with an improved algorithmNew silica‐rich locations are identified in the Oceanus Procellarum region [ABSTRACT FROM AUTHOR]

This paper aims to study the simultaneous adsorption of multiple heavy metal ions present in municipal solid waste (MSW) leachate. Leachate samples have been found to contain the heavy metal ions copper [Cu (1.22 mg/L)], zinc [Zn (2.86 mg/L)], lead [Pb (2.62 mg/L)], chromium [Cr (1.5 mg/L)], and nickel [Ni (0.65 mg/L)]. Ground granulated blast furnace slag (GGBS) will be used in this paper as adsorbent. The adsorptive capability of GGBS will be studied using the extended Langmuir isotherm model, Langmuir--Freundlich isotherm model, and multicomponent isotherm model. The extended Langmuir adsorption isotherm model fits the experimental values better than the other two models. The synergism, antagonism, and noninteraction effects will be studied based on the equilibrium metal uptake values. For all heavy metals present in the leachate used in this paper, the values of qmix/qo were >0, which indicated that multimetal adsorption was feasible by GGBS. This is the indication of enormous active sites on its surface. In addition, this was confirmed by the values of qmix/qo, because synergism was followed by antagonism. Ni ions showed a higher synergism effect that increased with an increase in GGBS dose. The adsorption effect of Cr experienced a transition from antagonism to synergism effect above 0.4 g of GGBS dose, which indicated the competition between Ni and Cr. The interactive effect for Pb fluctuated. Cu and Zn showed a strong antagonistic effect, Pb showed a moderate synergic effect, and Cr and Ni showed a strong synergic effect. The dose of GGBS has a predominant role in the adsorption of multiple heavy metal ions. [ABSTRACT FROM AUTHOR]

This work provided the adsorption method to removal phenol by using different coal particles. The characterization of the adsorbents was analyzed by Camsizer XT, FT-IR, X-ray diffusion and Brunauer-Emmett-Teller and Barrett-Joyner-Halenda. The adsorption capacity presents a linear increase as specific surface area increasing. To reveal the process of the adsorption, the adsorption kinetics and isotherms were performed. Pseudo-second-order was found to best represent the kinetics data, which indicated that the process belongs to chemisorption. The equilibrium isotherms data was analyzed by Langmuir model and Freundlich model, which indicated that the Freundlich model was good fitted for the adsorption processes. [ABSTRACT FROM AUTHOR]

In this study, some activated carbons were prepared from sawdust using NaOH as an impregnating agent, a full factorial plan 23 was adopted to optimize and determine the interaction effects of some preparation conditions: impregnation time, impregnation temperature, and impregnation ratio. Elimination efficiency toward Erythrosine and Methylene blue in single and binary systems was selected as an optimization measure. The results showed that both impregnation ratio and ratio-temperature interaction were the most effective effects. Activated carbon AC1 prepared in optimum conditions; a time of 2 h, an impregnation temperature of 85 °C and an impregnation ratio of (1:1); had a high specific surface area estimated at 991 m2.g−1 and a maximum elimination of dyes with efficiency more than 94%, which corresponds to 104 mg.g−1 and 72 mg.g−1 for the MB; 90 mg.g−1 and 65 mg.g−1 for the E127 in both systems. Adsorption kinetics of the two dyes by AC1 were correctly described by the pseudo-second order model. As for isotherm modeling, Langmuir model seems to be the most adequate to describe the experimental data with maximum adsorption capacities 111 mg.g−1 and 76 mg.g−1 for MB and 100 mg.g−1 and 71 mg.g−1 for E127 in single and in binary systems regularly. [ABSTRACT FROM AUTHOR]

Background/Aims. Optic disc drusen (ODD) are calcified deposits of proteinaceous material in the optic disc, and their burden in ocular conditions is unknown. As ODD can be associated with visual field defects further compromising already degenerating visual function in patients with retinal degenerations, it is important to further our knowledge of ODD in inherited eye disease. The present study aims to evaluate prevalence, demographic features, and optic disc parameters of eyes with superficial ODD in inherited eye conditions. Materials and Methods. Electronic medical records of patients evaluated in the Ophthalmic Genetics clinic at the National Eye Institute (NEI) between 2008 and 2018 were searched for a superficial ODD diagnosis. Color fundus and autofluorescence images were reviewed to confirm ODD, supplemented with optical coherence tomography (OCT) in uncertain cases when available. Demographic information, examination, and genetic testing were reviewed. Disc areas and disc-to-macula distance to disc diameter ratios (DM : DD) were calculated. Results. Fifty six of 6207 patients had photographically confirmed ODD (0.9%). Drusen were predominantly bilateral (66%), with a female (62%) and Caucasian (73%) predilection. ODD prevalence in our cohort of patients with inherited retinal degenerations was 2.5%, and ODD were more prevalent in the rod-cone dystrophy subgroup at 2.95% (OR = 3.3 [2.1–5.3], P < 0.001) compared to the ophthalmic genetics cohort. Usher patients were more likely to have ODD (10/132, 7.6%, OR = 9.0 [4.3–17.7], P < 0.001) and had significantly smaller discs compared to the rest of our ODD cohort (disc area: P = 0.001 , DM : DD: P = 0.03). Discussion. While an association between ODD and retinitis pigmentosa has been reported, this study surveys a large cohort of patients with inherited eye conditions and finds the prevalence of superficial ODD is lower than that in the literature. Some subpopulations, such as rod-cone dystrophy and Usher syndrome, had a higher prevalence than the cohort as a whole. [ABSTRACT FROM AUTHOR]

Permeable Pavement (PP) represents a good solution to solve stormwater management problems. In this way, the potential removal efficiency of a PP in treating dissolved metals was assessed by performing a monitoring campaign at a lab-scale system. Based on literature experiences, different relatively high-level concentrations of copper and zinc were applied during eight different synthetic rainfall events. Results have shown that the removal rates of Cu and Zn of the lab-scale system range from 85% to 92% and from 65% to 82%, respectively. In addition, batch experiments were carried out on each construction material of the PP highlighting that, among the materials tested, only concrete blocks presented the potential to adsorb the investigated metals. Results confirmed that the adsorption capacity of the blocks is higher in adsorbing Cu (70–90%) than Zn (69–75%). Results from LCA analysis have shown overall minimal long-term, indirect and cumulative impact. [ABSTRACT FROM AUTHOR]

Dysregulated RNA splicing is a molecular feature that characterizes almost all tumour types. Cancer-associated splicing alterations arise from both recurrent mutations and altered expression of trans-acting factors governing splicing catalysis and regulation. Cancer-associated splicing dysregulation can promote tumorigenesis via diverse mechanisms, contributing to increased cell proliferation, decreased apoptosis, enhanced migration and metastatic potential, resistance to chemotherapy and evasion of immune surveillance. Recent studies have identified specific cancer-associated isoforms that play critical roles in cancer cell transformation and growth and demonstrated the therapeutic benefits of correcting or otherwise antagonizing such cancer-associated mRNA isoforms. Clinical-grade small molecules that modulate or inhibit RNA splicing have similarly been developed as promising anticancer therapeutics. Here, we review splicing alterations characteristic of cancer cell transcriptomes, dysregulated splicing's contributions to tumour initiation and progression, and existing and emerging approaches for targeting splicing for cancer therapy. Finally, we discuss the outstanding questions and challenges that must be addressed to translate these findings into the clinic., (© 2023. Springer Nature Limited.)

A systematic study of the diffusion mechanism and effect of mass transfer limitation during the adsorption of CO2 onto polyaspartamide is presented using a differential adsorption bed method, carried out in a 100 × 60 × 40 mm packed-bed adsorption unit. The rate-limiting step where mass transfer limitation is dominant was studied using diffusion models. It was observed that intraparticle diffusion mechanism is the major contributor to the resistance offered to the transport of gas molecule through polyaspartamide. The behaviour of polyaspartamide, based on the intraparticle diffusion rate parameter derived from the plots of CO2 adsorbed versus the square root of time, signified that the adsorption mechanism involved both film and intraparticle diffusion. The intraparticle diffusion parameter (kid) obtained was dependent on temperature as well as intraparticle convection effects and ranged from 1.24 × 10−4 to 2.13 × 10−4 ms−1. The Biot number (Bi) values were all greater than 10 (ranged from 17.80 – 30.74), confirming that the intraparticle diffusion was the rate-limiting step and heat transfer is more by conduction from the gas film layer than convection within the pores of polyaspartamide. Results from this study provide an important basis for future scale-up and optimisation of CO2 capture process using polyaspartamide. [ABSTRACT FROM AUTHOR]

Early mammalian embryogenesis relies on a large range of cellular and molecular mechanisms to guide cell fate. In this highly complex interacting system, molecular circuitry tightly controls emergent properties, including cell differentiation, proliferation, morphology, migration, and communication. These molecular circuits include those responsible for the control of gene and protein expression, as well as metabolism and epigenetics. Due to the complexity of this circuitry and the relative inaccessibility of the mammalian embryo in utero , mammalian neural commitment remains one of the most challenging and poorly understood areas of developmental biology. In order to generate the nervous system, the embryo first produces two pluripotent populations, the inner cell mass and then the primitive ectoderm. The latter is the cellular substrate for gastrulation from which the three multipotent germ layers form. The germ layer definitive ectoderm, in turn, is the substrate for multipotent neurectoderm (neural plate and neural tube) formation, representing the first morphological signs of nervous system development. Subsequent patterning of the neural tube is then responsible for the formation of most of the central and peripheral nervous systems. While a large number of studies have assessed how a competent neurectoderm produces mature neural cells, less is known about the molecular signatures of definitive ectoderm and neurectoderm and the key molecular mechanisms driving their formation. Using pluripotent stem cells as a model, we will discuss the current understanding of how the pluripotent inner cell mass transitions to pluripotent primitive ectoderm and sequentially to the multipotent definitive ectoderm and neurectoderm. We will focus on the integration of cell signaling, gene activation, and epigenetic control that govern these developmental steps, and provide insight into the novel growth factor-like role that specific amino acids, such as L-proline, play in this process. [ABSTRACT FROM AUTHOR]