120 results on '"Ingman, Max"'
Search Results
2. Whole-genome resequencing reveals loci under selection during chicken domestication
- Author
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Rubin, Carl-Johan, Zody, Michael C., Eriksson, Jonas, Meadows, Jennifer R.S., Sherwood, Ellen, Webster, Matthew T., Jiang, Lin, Ingman, Max, Sharpe, Ted, Ka, Sojeong, Hallbook, Finn, Besnier, Francois, Carlborg, Orjan, Bed'hom, Bertrand, Tixier-Boichard, Michele, Jensen, Per, Siegel, Paul, Lindblad-Toh, Kerstin, and Andersson, Leif
- Subjects
Thyrotropin -- Physiological aspects -- Genetic aspects -- Research -- Models ,Hormone receptors -- Physiological aspects -- Genetic aspects -- Research -- Models ,Single nucleotide polymorphisms -- Research -- Physiological aspects -- Models -- Genetic aspects ,Chickens -- Models -- Genetic aspects -- Research -- Physiological aspects - Abstract
Domestic animals are excellent models for genetic studies of phenotypic evolution (1-3). They have evolved genetic adaptations to a new environment, the farm, and have been subjected to strong human-driven selection leading to remarkable phenotypic changes in morphology, physiology and behaviour. Identifying the genetic changes underlying these developments provides new insight into general mechanisms by which genetic variation shapes phenotypic diversity. Here we describe the use of massively parallel sequencing to identify selective sweeps of favourable alleles and candidate mutations that have had a prominent role in the domestication of chickens (Gallus gallus domesticus) and their subsequent specialization into broiler (meat-producing) and layer (egg-producing) chickens. We have generated 44.5-fold coverage of the chicken genome using pools of genomic DNA representing eight different populations of domestic chickens as well as red jungle fowl (Gallus gallus), the major wild ancestor (4). We report more than 7,000,000 single nucleotide polymorphisms, almost 1,300 deletions and a number of putative selective sweeps. One of the most striking selective sweeps found in all domestic chickens occurred at the locus for thyroid stimulating hormone receptor (TSHR), which has a pivotal role in metabolic regulation and photoperiod control of reproduction in vertebrates. Several of the selective sweeps detected in broilers overlapped genes associated with growth, appetite and metabolic regulation. We found little evidence that selection for loss-of-function mutations had a prominent role in chicken domestication, but we detected two deletions in coding sequences that we suggest are functionally important. This study has direct application to animal breeding and enhances the importance of the domestic chicken as a model organism for biomedical research., For most of their history, domestic chicken populations have been bred for two purposes, egg laying and meat production (5). The effective chicken population size must have been huge in [...]
- Published
- 2010
- Full Text
- View/download PDF
3. Polymorphisms in 9q32 and TSCOT are linked to cervical cancer in affected sib-pairs with high mean age at diagnosis
- Author
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Engelmark, Malin T., Ivansson, Emma L., Magnusson, Jessica J., Gustavsson, Inger M., Wyöni, Per-Ivan, Ingman, Max, Magnusson, Patrik K. E., and Gyllensten, Ulf B.
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- 2008
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4. Mitochondrial genomics identifies major haplogroups in Aboriginal Australians
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van Holst Pellekaan, Sheila M., Ingman, Max, Roberts-Thomson, June, and Harding, Rosalind M.
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Australian aborigines -- Research ,Mitochondria -- Research ,Population biology -- Research ,Anthropology/archeology/folklore - Abstract
We classified diversity in eight new complete mitochondrial genome sequences and 41 partial sequences from living Aboriginal Australians into five haplogroups. Haplogroup AuB belongs to global lineage M, and AuA, AuC, AuD, and AuE to N. Within N, we recognize subdivisions, assigning AuA to haplogroup S, AuD to haplogroup O, AuC to P4, and AuE to P8. On available evidence, [sup.S]AuA and [sup.M]AuB are widespread in Australia. [.sup.P4]AuC is found in the Riverine region of western New South Wales, and was identified by others in northern Australia. [sup.O]AuD and [sup.P8]AuE were clearly identified only from central Australia. Our eight Australian full mt genome sequences, combined with 20 others (Ingman and Gyllensten [2003] Genome Res. 13:1600-1606) and compared with full mt genome sequences from regions to the north that include Papua New Guinea, Malaya, and Andaman and Nicobar Islands, show that ancestral connections between regions are deep and limited to clustering at the level of the N and M macrohaplogroups. The Australian-specific distribution of the five haplogroups identified indicates genetic isolation over a long period. Ancestral connections within Australia are deeper than those reflected by known linguistic or culturally based affinities. Applying a coalescence analysis to a gene tree for the coding regions of the eight genomic sequences, we made estimates of time depth that support a continuity of presence for the descendants of a founding population already established by 40,000 years ago. KEY WORDS mtDNA; phylogeography; coalescence model; population history
- Published
- 2006
5. Mitochondrial genome variation and the origin of modern humans
- Author
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Ingman, Max, Kaessmann, Henrik, Paabo, Svante, and Gyllensten, Ulf
- Subjects
Environmental issues ,Science and technology ,Zoology and wildlife conservation - Abstract
Author(s): Max Ingman [1]; Henrik Kaessmann [2]; Svante Pääbo [2]; Ulf Gyllensten (corresponding author) [1] The analysis of mitochondrial DNA (mtDNA) has been a potent tool in our understanding of [...]
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- 2000
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6. Rate variation between mitochondrial domains and adaptive evolution in humans
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Ingman, Max and Gyllensten, Ulf
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- 2007
7. mtDB: Human Mitochondrial Genome Database, a resource for population genetics and medical sciences
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Ingman, Max and Gyllensten, Ulf
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- 2006
8. mtDB: Human Mitochondrial Genome Database, a resource for population genetics and medical sciences
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Ingman, Max, Gyllensten, Ulf, Ingman, Max, and Gyllensten, Ulf
- Abstract
The mitochondrial genome, contained in the subcellular mitochondrial network, encodes a small number of peptides pivotal for cellular energy production. Mitochondrial genes are highly polymorphic and cataloguing existing variation is of interest for medical scientists involved in the identification of mutations causing mitochondrial dysfunction, as well as for population genetics studies. Human Mitochondrial Genome Database (mtDB) (http://www.genpat.uu.se/mtDB) has provided a comprehensive database of complete human mitochondrial genomes since early 2000. At this time, owing to an increase in the number of published complete human mitochondrial genome sequences, it became necessary to provide a web-based database of human whole genome and complete coding region sequences. As of August 2005 this database contains 2104 sequences (1544 complete genome and 560 coding region) available to download or search for specific polymorphisms. Of special interest to medical researchers and population geneticists evaluating specific positions is a complete list of (currently 3311) mitochondrial polymorphisms among these sequences. Recent expansions in the capabilities of mtDB include a haplotype search function and the ability to identify and download sequences carrying particular variants
- Published
- 2017
9. Mitochondrial genome variation and evolutionary history of Australian and New Guinean aborigens
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Ingman, Max and Gyllensten, Ulf
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Evolution -- Genetic aspects ,Population genetics -- Research ,Australian aborigines -- Genetic aspects ,Variation (Biology) -- Genetic aspects ,Genetic research -- Analysis ,Genomes -- Research ,Health - Abstract
Research has been conducted on Australian and New Guinean indigenous peoples. The study of the evolutionary history of these peoples has been carried out via the analysis of mitochondrial genomes, and the results suggest the possibility of a joint colonization and admixture between the two regions.
- Published
- 2003
10. Mitochondria and Human Evolution
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Ingman, Max
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mitochondria ,human evolution ,Genetics ,hominidae ,population genetics ,Genetik ,Medical Genetics ,Medicinsk genetik - Abstract
Mitochondrial DNA (mtDNA) has been a potent tool in studies of the evolution of modern humans, human migrations and the dynamics of human populations over time. The popularity of this cytoplasmic genome has largely been due to its clonal inheritance (in Man) allowing the tracing of a direct genetic line. In addition, a comparatively high rate of nucleotide substitution facilitates phylogenetic resolution among relatively closely related individuals of the same species. In this thesis, a statistically supported phylogeny based on complete mitochondrial genome sequences is presented which, for the first time, unambiguously places the root of modern human mitochondrial lineages in Africa in the last 200 thousand years. This conclusion provides strong support for the “recent African origin” hypothesis. Also, the complete genome data underline the problematic nature of traditional approaches to analyses of mitochondrial phylogenies. The dispersal of anatomically modern humans from the African continent is examined through single nucleotide polymorphism (SNP) and sequence data. These data imply an expansion from Africa about 57 thousand years ago and a subsequent population dispersal into Asia. The dispersal coincides with a major population division that may be the result of multiple migratory routes to East Asia. Also investigated is the question of a common origin for the indigenous peoples of Australia and New Guinea. Previous studies have been equivocal on this question with some presenting evidence for a common genetic origin and other proposing separate histories. Our data reveals an ancient genetic link between Australian Aborigines and the peoples of the New Guinea highlands.
- Published
- 2003
11. Ultra-deep sequencing of mouse mitochondrial DNA : Mutational patterns and their origins
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Ameur, Adam, Stewart, James B., Freyer, Christoph, Hagström, Erik, Ingman, Max, Larsson, Nils-Göran, Gyllensten, Ulf, Ameur, Adam, Stewart, James B., Freyer, Christoph, Hagström, Erik, Ingman, Max, Larsson, Nils-Göran, and Gyllensten, Ulf
- Abstract
Somatic mutations of mtDNA are implicated in the aging process, but there is no universally accepted method for their accurate quantification. We have used ultra-deep sequencing to study genome-wide mtDNA mutation load in the liver of normally- and prematurely-aging mice. Mice that are homozygous for an allele expressing a proof-reading-deficient mtDNA polymerase (mtDNA mutator mice) have 10-times-higher point mutation loads than their wildtype siblings. In addition, the mtDNA mutator mice have increased levels of a truncated linear mtDNA molecule, resulting in decreased sequence coverage in the deleted region. In contrast, circular mtDNA molecules with large deletions occur at extremely low frequencies in mtDNA mutator mice and can therefore not drive the premature aging phenotype. Sequence analysis shows that the main proportion of the mutation load in heterozygous mtDNA mutator mice and their wildtype siblings is inherited from their heterozygous mothers consistent with germline transmission. We found no increase in levels of point mutations or deletions in wildtype C57Bl/6N mice with increasing age, thus questioning the causative role of these changes in aging. In addition, there was no increased frequency of transversion mutations with time in any of the studied genotypes, arguing against oxidative damage as a major cause of mtDNA mutations. Our results from studies of mice thus indicate that most somatic mtDNA mutations occur as replication errors during development and do not result from damage accumulation in adult life.
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- 2011
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12. Genetic origin of the Swedish Sami inferred from HLA class I and class II allele frequencies
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Johansson, Åsa, Ingman, Max, Mack, Steven J, Erlich, Henry, Gyllensten, Ulf, Johansson, Åsa, Ingman, Max, Mack, Steven J, Erlich, Henry, and Gyllensten, Ulf
- Abstract
Sami of northern Scandinavia are genetic outliers among European populations and their origin has been difficult to determine. In order to study the genetic origin of the Swedish Sami, we have performed high-resolution typing of the class I HLA-A and -B loci and the class II DRB1, DQB1 and DQA1 loci in the northern and southern Swedish Sami. Several of the common class I alleles in Sami (B*0702, B*1501, B*4002 and A*0301) are found at high frequency in other European populations. However, a number of class I and class II alleles (B*4001, A*2402, DRB1*0901 and DRB1*1101) in the Swedish Sami are characteristic of Asian populations. Admixture analyses indicate that 87% of the Sami gene pool is of European origin and that the Asian contribution is 13%. Our HLA analyses indicate a higher proportion of Asian ancestry in the Sami than shown by previous genetic studies.
- Published
- 2008
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13. SNP frequency estimation using massively parallel sequencing of pooled DNA
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Ingman, Max, Gyllensten, Ulf, Ingman, Max, and Gyllensten, Ulf
- Abstract
Resequencing of genomic regions that have been implicated by linkage and/or association studies to harbor genetic susceptibility loci represents a necessary step to identify causal variants. Massively parallel sequencing (MPS) offers the possibility of SNP discovery and frequency determination among pooled DNA samples. The strategies of pooling DNA samples and pooling PCR amplicons generated from individual DNA samples were evaluated, and both were found to return accurate estimates of SNP frequencies across varying levels of sequence coverage.European Journal of Human Genetics advance online publication, 15 October 2008; doi:10.1038/ejhg.2008.182., Advance online publication, 15 October 2008
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- 2008
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14. Polymorphisms in 9q32 and TSCOT are linked to cervical cancer in affected sib-pairs with high mean age at diagnosis
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Engelmark, Malin, Ivansson, Emma, Magnusson, Jessica, Gustavsson, Inger, Wyöni, Per-Ivan, Ingman, Max, Magnusson, Patrik, Gyllensten, Ulf, Engelmark, Malin, Ivansson, Emma, Magnusson, Jessica, Gustavsson, Inger, Wyöni, Per-Ivan, Ingman, Max, Magnusson, Patrik, and Gyllensten, Ulf
- Abstract
Cervical cancer is a multifactorial disease influenced by both environmental and genetic factors. We have previously found linkage to 9q32 in a genomewide scan of affected sib-pairs (ASPs) with cervical cancer and to the thymic stromal co-transporter (TSCOT), a candidate gene in this region. Here we examined the contribution of 9q32 and TSCOT to cervical cancer susceptibility using at larger material of 641 ASPs, 278 of which were included in the earlier genome-scan. Since heritable forms of cancer frequently show stronger genetic effects in families with early onset of disease, we stratified the ASPs into two groups based on mean age at diagnosis (MAAD) within sib-pairs. Surprisingly, ASPs with high MAAD (30.5-47.5 years) showed increased sharing at all microsatellite markers at 9q31.1-33.1 and linkage signals of up to MLS = 2.74 for TSCOT SNPs, while ASPs with low MAAD (19-30 years) showed no deviation from random genetic sharing (MLS = 0.00). The difference in allelic sharing between the two MAAD strata was significant (P < 0.005) and is not likely to be explained by the HLA haplotype, a previously known genetic susceptibility factor for cervical cancer. Our results indicate locus heterogeneity in the susceptibility to cervical cancer between the two strata, with polymorphisms in the 9q32 region mainly showing an effect in women with high MAAD.
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- 2008
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15. A recent genetic link between Sami and the Volga-Ural region of Russia
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Ingman, Max, Gyllensten, Ulf, Ingman, Max, and Gyllensten, Ulf
- Abstract
The genetic origin of the Sami is enigmatic and contributions from Continental Europe, Eastern Europe and Asia have been proposed. To address the evolutionary history of northern and southern Swedish Sami, we have studied their mtDNA haplogroup frequencies and complete mtDNA genome sequences. While the majority of mtDNA diversity in the northern Swedish, Norwegian and Finnish Sami is accounted for by haplogroups V and U5b1b1, the southern Swedish Sami have other haplogroups and a frequency distribution similar to that of the Continental European population. Stratification of the southern Sami on the basis of occupation indicates that this is the result of recent admixture with the Swedish population. The divergence time for the Sami haplogroup V sequences is 7600 YBP (years before present), and for U5b1b1, 5500 YBP amongst Sami and 6600 YBP amongst Sami and Finns. This suggests an arrival in the region soon after the retreat of the glacial ice, either by way of Continental Europe and/or the Volga-Ural region. Haplogroup Z is found at low frequency in the Sami and Northern Asian populations but is virtually absent in Europe. Several conserved substitutions group the Sami Z lineages strongly with those from Finland and the Volga-Ural region of Russia, but distinguish them from Northeast Asian representatives. This suggests that some Sami lineages shared a common ancestor with lineages from the Volga-Ural region as recently as 2700 years ago, indicative of a more recent contribution of people from the Volga-Ural region to the Sami population.
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- 2007
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16. Lifestyle, genetics, and disease in Sami.
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Ross, Alastair B, Johansson, Asa, Ingman, Max, Gyllensten, Ulf, Ross, Alastair B, Johansson, Asa, Ingman, Max, and Gyllensten, Ulf
- Published
- 2006
17. Ultra-Deep Sequencing of Mouse Mitochondrial DNA: Mutational Patterns and Their Origins
- Author
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Ameur, Adam, primary, Stewart, James B., additional, Freyer, Christoph, additional, Hagström, Erik, additional, Ingman, Max, additional, Larsson, Nils-Göran, additional, and Gyllensten, Ulf, additional
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- 2011
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18. Analysis of the complete human mtDNA genome : methodology and inferences for human evolution
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Ingman, Max, Gyllensten, Ulf, Ingman, Max, and Gyllensten, Ulf
- Abstract
The analysis of mitochondrial DNA (mtDNA) sequences has been a potent tool in our understanding of human evolution. However, almost all studies of human evolution based on mtDNA sequencing have focused on the control region, which constitutes less than 7% of the mitochondrial genome. The rapid development of technology for automated DNA sequencing has made it possible to study the complete mtDNA genomes in large numbers of individuals, opening the field of mitochondrial population genomics. Here we describe a suitable methodology for determining the complete human mitochondrial sequence and the global mtDNA diversity in humans. Also, we discuss the implications of the results with respect to the different hypotheses for the evolution of modern humans.
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- 2001
19. SNP frequency estimation using massively parallel sequencing of pooled DNA
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Ingman, Max, primary and Gyllensten, Ulf, additional
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- 2008
- Full Text
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20. Genetic origin of the Swedish Sami inferred from HLA class I and class II allele frequencies
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Johansson, Åsa, primary, Ingman, Max, additional, Mack, Steven J, additional, Erlich, Henry, additional, and Gyllensten, Ulf, additional
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- 2008
- Full Text
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21. A recent genetic link between Sami and the Volga-Ural region of Russia
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Ingman, Max, primary and Gyllensten, Ulf, additional
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- 2006
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22. Vertebrate Mitochondrial DNA
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Ingman, Max, primary and Gyllensten, Ulf, additional
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- 2006
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23. correction: Mitochondrial genome variation and the origin of modern humans
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Ingman, Max, Kaessmann, Henrik, Paabo, Svante, and Gyllensten, Ulf
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Environmental issues ,Science and technology ,Zoology and wildlife conservation - Abstract
Author(s): Max Ingman; Henrik Kaessmann; Svante Pääbo; Ulf Gyllensten Nature 408 , 708 - 712 (2000 ). The complete mtDNA sequences upon which the analyses are based can be found [...]
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- 2001
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24. Erratum: correction: Mitochondrial genome variation and the origin of modern humans
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Ingman, Max, primary, Kaessmann, Henrik, additional, Pääbo, Svante, additional, and Gyllensten, Ulf, additional
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- 2001
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25. SNP frequency estimation using massively parallel sequencing of pooled DNA.
- Author
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Ingman, Max and Gyllensten, Ulf
- Subjects
- *
DNA , *HUMAN genetics , *NUCLEOTIDE sequence , *GENE expression , *POLYMERASE chain reaction , *GENETIC code - Abstract
Resequencing of genomic regions that have been implicated by linkage and/or association studies to harbor genetic susceptibility loci represents a necessary step to identify causal variants. Massively parallel sequencing (MPS) offers the possibility of SNP discovery and frequency determination among pooled DNA samples. The strategies of pooling DNA samples and pooling PCR amplicons generated from individual DNA samples were evaluated, and both were found to return accurate estimates of SNP frequencies across varying levels of sequence coverage.European Journal of Human Genetics (2009) 17, 383–386; doi:10.1038/ejhg.2008.182; published online 15 October 2008 [ABSTRACT FROM AUTHOR]
- Published
- 2009
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26. Mitochondrial haplotype distribution and ancient human migrations
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Ingman, Max, Gyllensten, Ulf, Ingman, Max, and Gyllensten, Ulf
27. mtDB: Human Mitochondrial Genome Database, a resource for population genetics and medical sciences
- Author
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Ingman, Max, Gyllensten, Ulf, Ingman, Max, and Gyllensten, Ulf
- Abstract
The mitochondrial genome, contained in the subcellular mitochondrial network, encodes a small number of peptides pivotal for cellular energy production. Mitochondrial genes are highly polymorphic and cataloguing existing variation is of interest for medical scientists involved in the identification of mutations causing mitochondrial dysfunction, as well as for population genetics studies. Human Mitochondrial Genome Database (mtDB) (http://www.genpat.uu.se/mtDB) has provided a comprehensive database of complete human mitochondrial genomes since early 2000. At this time, owing to an increase in the number of published complete human mitochondrial genome sequences, it became necessary to provide a web-based database of human whole genome and complete coding region sequences. As of August 2005 this database contains 2104 sequences (1544 complete genome and 560 coding region) available to download or search for specific polymorphisms. Of special interest to medical researchers and population geneticists evaluating specific positions is a complete list of (currently 3311) mitochondrial polymorphisms among these sequences. Recent expansions in the capabilities of mtDB include a haplotype search function and the ability to identify and download sequences carrying particular variants
28. Contemporary Version of the Monogenetic Model of Anthropogenesis—Some Critical Remarks from the Thomistic Perspective.
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Tabaczek, Mariusz
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PALEOANTHROPOLOGY ,HUMAN genetics ,HUMAN origins ,HUMAN beings ,GENETIC speciation - Abstract
This article refers to the debate between proponents of mono- and polygenism. After clearly defining these two positions in reference to the distinction between mono- and polyphyletism, it presents the scientific consensus in favor of polygenism as the default model of speciation. Taking this into account, the remaining part of the article concentrates on the monogenetic model of human speciation. Approaching this topic from the Aristotelian–Thomistic perspective, it delineates the three main theological arguments and one more scientifically grounded contention in favor of monogenism and offers a critical evaluation of Kenneth Kemp's contemporary model of theological monogenism grounded in biological polygenism. While viable, consistent, and remaining in line with the most recent paleoanthropology and human genetics, it needs to be cleared of its voluntaristic and dualistic undertones and reformulated in a way that avoids its implicit assumption of a metaphysically dubious substantial change taking place at the last step of the origin of Homo sapiens. [ABSTRACT FROM AUTHOR]
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- 2023
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29. Lifestyle, Genetics, and Disease in Sami.
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Ross, Alastair B., Johansson, Åsa, Ingman, Max, and Gyllensten, Ulf
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LIFESTYLES , *GENETICS , *INDIGENOUS peoples , *DIET , *CANCER - Abstract
Aim To present a summary of the lifestyle, genetic origin, diet, and disease in the population of Sami, indigenous people of northern Fennoscandia. Method A survey of the available scientific literature and preliminary results from our own study of the Swedish Sami population. Results The Sami probably have a heterogeneous genetic origin, with a major contribution of continental or Eastern European tribes and a smaller contribution from Asia. The traditional Sami diet, high in animal products, persists in Sami groups still involved with reindeer herding, but others have adopted a diet typical of Western cultures. Early reports indicated a lower prevalence of heart disease and most cancers, except stomach cancer. Recent studies have not found a lower risk of heart disease, but have consistently shown an overall reduced cancer risk. Sami have been reported to share some specific health-related genetic polymorphisms with other European populations, but none that would explain the observed differences in disease risk. Conclusion The genetic structure of the Sami population makes it suitable for studies of the genetic and environmental factors influencing the development of common diseases. The difference in incidence of heart disease between studies may reflect the ongoing transition from a traditional to a more Westernized lifestyle. The ability to compare population segments with different lifestyles, combined with the genetic structure of the population, creates unusual possibilities for studies of the genetic and environmental factors involved in the development of common disease. [ABSTRACT FROM AUTHOR]
- Published
- 2006
30. Human Colonization of Asia in the Late Pleistocene: An Introduction to Supplement 17.
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Bae, Christopher J., Douka, Katerina, and Petraglia, Michael D.
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COLONIZATION ,PREHISTORIC peoples ,PLEISTOCENE Epoch ,ARCHAEOLOGICAL human remains ,ARCHAEOLOGICAL assemblages - Abstract
The origin and evolution of modern humans continues to be of great interest to the scientific and public communities alike; the field has long been dominated by findings from Europe and Africa. With new discoveries of hominin fossils and archaeological sites, in addition to the application of recent genomic and paleoclimate modeling studies, findings from Asia are serving to revolutionize the field of modern human origins. The identification of Neanderthals and Denisovans in Siberia, for example, along with growing fossil and archaeological evidence for the presence of early modern humans in East and Southeast Asia, much earlier than originally thought, places the spotlight on the evolutionary history of our species in Asia over the last 125,000 years. Exciting and unanticipated new discoveries call for a need to critically reexamine the Asian record. Taking a multidisciplinary perspective, a group of active researchers participated in a week-long Wenner-Gren symposium titled "Human Colonization of Asia in the Late Pleistocene" (#153) in March 2016. Here we review the major themes and findings emerging from the symposium and discuss avenues to move the field forward. [ABSTRACT FROM AUTHOR]
- Published
- 2017
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31. Typological bottlenecks: How large-scale regional language typologies help us interpret global prehistory.
- Author
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Blench, Roger
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LINGUISTIC typology ,HISTORICAL linguistics ,ARCHAEOLOGISTS ,HOMOGENEITY ,AUSTRALIAN languages - Abstract
It is unlikely that local or highly specific typological characteristics of language correlate with other aspects of human culture and history. However, at regional scale, the broad typology of languages does reflect bottlenecks. The paper argues that these regions of high typological similarity are due neither to chance nor long-term convergence, but reflect the initial conditions of settlement. This suggests that regions can be characterised by negative typology, i.e., the absence of globally common traits. Conversely, typological uniformity occurs in mainland Southeast Asia, a region notable for the similarities between language structures. An expansion of the remit of typology can uncover large regional patterns which can be tied to the archaeological narrative of the early expansion of modern humans. [ABSTRACT FROM AUTHOR]
- Published
- 2016
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32. Craniofacial Feminization, Social Tolerance, and the Origins of Behavioral Modernity.
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Cieri, Robert L., Churchill, Steven E., Franciscus, Robert G., Tan, Jingzhi, Hare, Brian, Athreya, Sheela, Holliday, Trenton W., Nowell, April, Steele, Teresa E., Weaver, Timothy D., and Wrangham, Richard
- Subjects
SOCIAL evolution ,HUMAN behavior ,FACIAL bones ,HUMAN beings ,ANDROGENS ,TESTOSTERONE ,POPULATION density - Abstract
The past 200,000 years of human cultural evolution have witnessed the persistent establishment of behaviors involving innovation, planning depth, and abstract and symbolic thought, or what has been called "behavioral modernity." Demographic models based on increased human population density from the late Pleistocene onward have been increasingly invoked to understand the emergence of behavioral modernity. However, high levels of social tolerance, as seen among living humans, are a necessary prerequisite to life at higher population densities and to the kinds of cooperative cultural behaviors essential to these demographic models. Here we provide data on craniofacial feminization (reduction in average brow ridge projection and shortening of the upper facial skeleton) in Homo sapiens from the Middle Pleistocene to recent times. We argue that temporal changes in human craniofacial morphology reflect reductions in average androgen reactivity (lower levels of adult circulating testosterone or reduced androgen receptor densities), which in turn reflect the evolution of enhanced social tolerance since the Middle Pleistocene. [ABSTRACT FROM AUTHOR]
- Published
- 2014
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33. Assimilation of the Sámi: Its Unforeseen Effects on the Majority Populations of Scandinavia.
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Weinstock, John
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SAMI (European people) ,ASSIMILATION (Sociology) ,HUMAN mitochondrial DNA ,Y chromosome ,SCANDINAVIANS ,MISCEGENATION ,PHYLOGEOGRAPHY - Abstract
The article discusses the assimilation of the Sámi ethnic group in Scandinavia by the Finns, Swedes and Norwegians until the 1980s. Particular focus is given to the farmer settlers of the peninsula, Scandinavian phylogeographic data including mtDNA and Y-chromosome haplogroups, and the genetic admixture which occurred despite the Swedish politics of segregation.
- Published
- 2013
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34. Making it transparent. On naming, framing and administrating biobank research on native people.
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Svalastog, AnnaLydia
- Subjects
EPIDEMIOLOGICAL research ,BIOBANKS ,GENETIC research ,BLOOD sampling - Abstract
Despite more than 50 years of genetic research on Sámi people in Sweden, there has been very little engagement with the ethical issues related to this research. My aim is to investigate the ethical challenges in biobank research on Sámi people, to identify ethical challenges that have been overlooked and to find ethical solutions. In my historical research inquiry of published material and interviews with people that have participated in this research, my research questions have been: How are blood samples from Sámi people collected, codified, governed and analyzed? What ethical strategies have been utilized? My main findings are: Sweden acquired biobank collections from Sámi people that are not registered or cannot be traced through the biobank register at the Swedish National Board of Health and Welfare. These collections entail ethical challenges concerning how the donors are identified, how the material is categorized, the regional ethical committees, governance and Sámi representation. My suggestions focus on transparency and traceability, competence and native peoples' rights and representation in biobank-related activities. [ABSTRACT FROM AUTHOR]
- Published
- 2013
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35. Healing in the Sámi North.
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Sexton R, Stabbursvik EA, Sexton, Randall, and Stabbursvik, Ellen Anne Buljo
- Abstract
There is a special emphasis today on integrating traditional healing within health services. However, most areas in which there is a system of traditional healing have undergone colonization and a number of pressures suppressing tradition for hundreds of years. The question arises as to how one can understand today's tradition in light of earlier traditions. This article is based on material collected in Sámi areas of Finnmark and Nord-Troms Norway; it compares local healing traditions with what is known of earlier shamanic traditions in the area. The study is based on 27 interviews among healers and their patients. The findings suggest that although local healing traditions among the Sámi in northern Norway have undergone major transformations during the last several hundred years, they may be considered an extension of a long-standing tradition with deep roots in the region. Of special interest are also the new forms tradition may take in today's changing global society. [ABSTRACT FROM AUTHOR]
- Published
- 2010
- Full Text
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36. THESES.
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Terrell, Jennifer
- Subjects
ACADEMIC dissertations ,DIPLOMACY - Abstract
The article provides information on the thesis list presented up to early 2004. Information on recently completed theses would be greatly appreciated. Thanks are due to Frédéric Angleviel, Bronwen Douglas, Chris Ballard and Peter Hempenstall for assistance. Katherine Anderson has written a paper on "Tuna Politics in Oceania: The Effectiveness of Collective Diplomacy." Brian S. Andres has written a paper on "A Qualitative Phenomenological Analysis of the Critical Incidents in the Native Hawaiian Peacemaking Process of 'Ho'oponopono'."
- Published
- 2004
- Full Text
- View/download PDF
37. Babies in Groups : Expanding Imaginations
- Author
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Ben S. Bradley, Jane Selby, Matthew Stapleton, Ben S. Bradley, Jane Selby, and Matthew Stapleton
- Subjects
- Infants--Development, Infant psychology
- Abstract
This is an open access title available under the terms of a CC BY-NC-ND 4.0 International licence. It is free to read on the Oxford Academic platform and offered as a free PDF download from OUP and selected open access locations. Research has shown that young babies - well before they form their first bond to a caring adult - enjoy participating in groups and group processes. Babies in Groups examines the consequences of these findings for science, for early education practice and policy, and for adult psychotherapy. The authors report research showing the extensive capacity of preverbal infants for group-communication in all-baby trios and quartets, backed by findings about primate sociability, the social brain, cultural histories, and human evolution. These studies open up new ways of imagining human development as fundamentally group-based. In addition, the authors explore the changes that a group-based vision of infancy could bring to early child education and care. They also show how ignoring group contexts in many clinical traditions can distort descriptions of what happens in therapy, producing such unintended consequences as'mother-blaming'for the future problems an infant may experience as she or he grows up. Finally, the book's appendix summarises the main forms of evidence which falsify claims that science has proven that an inborn gift for dyadic'intersubjectivity,'or for one-to-one infant-adult attachments, founds human social development.
- Published
- 2024
38. Theistic Evolution : A Contemporary Aristotelian-Thomistic Perspective
- Author
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Mariusz Tabaczek and Mariusz Tabaczek
- Subjects
- Religion
- Abstract
In this book, Mariusz Tabaczek develops a contemporary, re-imagined proposal of an Aristotelian-Thomistic perspective on theistic evolution. Deeply rooted in classical philosophy and theology, the volume combines careful textual analysis of ancient, medieval, and contemporary literature with innovative, original, and constructive argumentation and modelling. Tabaczek offers a wide-ranging set of arguments on behalf of those who advocate for the relevance of classical philosophical and theological thought in the context of contemporary science and the dialogue between science and religion. Avoiding simplistic answers to complex questions concerning the origin of species, including the human species, his book inspires critical thinking and a systematic approach to all major philosophical presuppositions and both philosophical and theological repercussions of the theory of evolution. Without contradicting or abandoning the letter of the tradition, Tabaczek echoes the spirit of Aristotle's and Aquinas's philosophy and theology, moving them forward to embrace the evolutionary aspect of the contemporary view of reality.
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- 2023
39. Languages of the Himalayas : Volume 2
- Author
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George van Driem and George van Driem
- Abstract
The survey work Languages of the Himalayas provides a bird's eye view of Himalayan languages and language communities. It also constitutes a primary source for much new, hitherto unpublished data on several languages. The demographic mosaic of the Himalayas today is viewed in a historical and comparative linguistic perspective. The reader will find an outline of the historical and prehistorical developments that have determined the modern ethnolinguistic composition of the Himalayan region, involving various independent linguistics stocks or language families. Maps illustrate the distribution of language communities and trace the routes of ancient migrations. There is an illuminating discussion of grammatical features found in Himalayan languages. The print edition is available as a set of two volumes (9789004103900).
- Published
- 2022
40. Music in Human Experience: Perspectives on a Musical Species
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Jonathan L. Friedmann, Editor and Jonathan L. Friedmann, Editor
- Subjects
- Music--Philosophy and aesthetics
- Abstract
Music plays an integral role in many facets of human life, from the biological and social to the spiritual and political. This book brings together interdisciplinary and cross-cultural studies on the functions, purposes, and meanings of music in human experience.
- Published
- 2022
41. Language Dispersal, Diversification, and Contact
- Author
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Mily Crevels, Pieter Muysken, Mily Crevels, and Pieter Muysken
- Subjects
- Language and languages--Variation, Language spread, Languages in contact
- Abstract
This book addresses the complex question of how and why languages have spread across the globe: why do we find large language families distributed over a wide area in some regions, while elsewhere we find clusters of very small families or language isolates? What roles have agriculture, geography, climate, ethnic identity, and language ideologies played in language spread? In this volume, international experts in the field provide new answers to these and related questions, drawing on the increasingly large databases available and on novel analytical research techniques. The first part of the volume outlines some general issues and approaches in the study of language dispersal, diversification, and contact. In the rest of the volume, chapters compare the language and population histories of three major regions - Island Southeast Asia/Oceania, Africa, and South America - which show particularly interesting contrasts in the distribution of languages and language families. The volume is interdisciplinary in approach, with insights from archaeology, genetics, anthropology, and geography, and will be of interest to a wide range of scholars interested in language diversity and contact.
- Published
- 2020
42. The Palgrave Handbook of Climate History
- Author
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Sam White, Christian Pfister, Franz Mauelshagen, Sam White, Christian Pfister, and Franz Mauelshagen
- Subjects
- Climatology--History--Handbooks, manuals, etc
- Abstract
This handbook offers the first comprehensive, state-of-the-field guide to past weather and climate and their role in human societies. Bringing together dozens of international specialists from the sciences and humanities, this volume describes the methods, sources, and major findings of historical climate reconstruction and impact research. Its chapters take the reader through each key source of past climate and weather information and each technique of analysis; through each historical period and region of the world; through the major topics of climate and history and core case studies; and finally through the history of climate ideas and science. Using clear, non-technical language, The Palgrave Handbook of Climate History serves as a textbook for students, a reference guide for specialists and an introduction to climate history for scholars and interested readers.
- Published
- 2018
43. Die Evolution der humanen Lebensform als geistige Lebensform : Handeln • Denken • Sprechen
- Author
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Günter Dux and Günter Dux
- Subjects
- Evolutionary psychology, Human evolution
- Abstract
Die vorliegende Studie befasst sich mit der Lebensform des Menschen als geistige Lebensform. Seit wir wissen, dass die Lebensform des Menschen einem säkular verstandenen Universum zugehört und sich aus der Evolution heraus gebildet hat, ist die Frage unabweisbar, wodurch sie als geistige Lebensform möglich geworden ist. Die Frage hat aber bisher nicht nur keine Antwort gefunden, sie ist als Frage geradezu blockiert worden. Geist scheint entweder am Grunde des Universums gelegen zu sein, in dem er dem säkular gewordenen Naturverständnis nicht zuzurechnen ist oder aber als Vermögen eines Subjekts verstanden zu werden, das mit diesem Vermögen ebenfalls aus der Natur herausgenommen zu sein scheint. Vom Geist wird, mit einem Wort, gesagt, in der Welt zu sein, ohne von der Welt zu sein, jedenfalls nicht von der, die wir in der Neuzeit im Verständnis des Universums gewonnen haben.
- Published
- 2017
44. La filosofía tomista ante el hecho de la evolución del viviente corpóreo: consideraciones metodológicas y conceptuales para una integración
- Author
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Juan Eduardo Carreño Pavez and Juan Eduardo Carreño Pavez
- Subjects
- Neo-Scholasticism, Life--Origin, Thomism, Evolution (Biology)--Religious aspects, Evolution (Biology)--Philosophy
- Abstract
Esta investigación precisa las dificultades reales que plantea la integración del hecho de la evolución del viviente corpóreo, en la doctrina de Santo Tomás de Aquino y cómo las han enfrentado otros autores ligados a la tradición tomista. Se examinan también la trayectoria que ha seguido la inteligencia humana en su reconocimiento del hecho evolutivo, el encuentro de la tradición tomista con las teorías evolutivas y la recepción que le han brindado los autores tomistas a la idea de una evolución biológica.
- Published
- 2017
45. Modern Humans : Their African Origin and Global Dispersal
- Author
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John F. Hoffecker and John F. Hoffecker
- Subjects
- Human beings--Migrations, Human beings--Origin, Human evolution
- Abstract
Modern Humans is a vivid account of the most recent—and perhaps the most important—phase of human evolution: the appearance of anatomically modern people (Homo sapiens) in Africa less than half a million years ago and their later spread throughout the world. Leaving no stone unturned, John F. Hoffecker demonstrates that Homo sapiens represents a “major transition” in the evolution of living systems in terms of fundamental changes in the role of non-genetic information. Modern Humans synthesizes recent findings from genetics (including the rapidly growing body of ancient DNA), the human fossil record, and archaeology relating to the African origin and global dispersal of anatomically modern people. Hoffecker places humans in the broad context of the evolution of life, emphasizing the critical role of genetic and non-genetic forms of information in living systems as well as how changes in the storage, transmission, and translation of information underlie major transitions in evolution. He also draws on information and complexity theory to explain the emergence of Homo sapiens in Africa several hundred thousand years ago and the rapid and unprecedented spread of our species into a variety of environments in Australia and Eurasia, including the Arctic and Beringia, beginning between 75,000 and 60,000 years ago. This magisterial work will appeal to all with an interest in the ever-fascinating field of human evolution.
- Published
- 2017
46. The Languages of Scandinavia : Seven Sisters of the North
- Author
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Ruth H. Sanders and Ruth H. Sanders
- Subjects
- Scandinavian languages--History
- Abstract
From fjords to mountains, schools of herring to herds of reindeer, Scandinavia is rich in astonishing natural beauty. Less well known, however, is that it is also rich in languages. Home to seven languages, Scandinavia has traditionally been understood as linguistically bifurcated between its five Germanic languages (Danish, Norwegian, Swedish, Icelandic, and Faroese) and its two Finno-Ugric ones (Finnish and Sámi). In The Languages of Scandinavia, Ruth H. Sanders takes a pioneering approach: she considers these Seven Sisters of the North together. While the two linguistic families that comprise Scandinavia's languages ultimately have differing origins, the Seven Sisters have coexisted side by side for millennia. As Sanders reveals, a crisscrossing of names, territories, and even to some extent language genetics—intimate language contact—has created a body of shared culture, experience, and linguistic influences that is illuminated when the story of these seven languages is told as one. Exploring everything from the famed whalebone Lewis Chessmen of Norse origin to the interactions between the Black Death and the Norwegian language, The Languages of Scandinavia offers profound insight into languages with a cultural impact deep-rooted and far-reaching, from the Icelandic sagas to Swedish writer Stieg Larsson's internationally popular Millennium trilogy. Sanders's book is both an accessible work of linguistic scholarship and a fascinating intellectual history of language.
- Published
- 2017
47. Doing Ancient DNA : Zur Wissenschaftsgeschichte der aDNA-Forschung
- Author
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Elsbeth Bösl and Elsbeth Bösl
- Subjects
- Archaeology--Research, Human genetics--History, DNA--Research--History, Human genetics--Research, Archaeology--Reserach
- Abstract
Die internationale aDNA-Community bearbeitet seit den 1980er Jahren (u.a. historische) Fragestellungen auf der Quellenbasis alter Moleküle - und aktuell diskutieren Historiker_innen die Quelle DNA unter dem Stichwort »Genetic History«. Wie haben Genetiker_innen, Molekularbiolog_innen, Anthropolog_innen und Archäolog_innen im überfachlichen Miteinander die Quelle DNA hergestellt - auf der Ausgrabung, im Labor und am Rechner? Welche epistemologischen und fachpolitischen Zielsetzungen verfolgten sie und wie hat sich die aDNA-Forschung in technischer und methodischer Hinsicht entwickelt? Welche Charakteristika, Chancen und Grenzen hat die Quelle aDNA? Aus wissenschaftshistorischer Perspektive befasst sich Elsbeth Bösl mit der Historie des epistemischen Objektes alte DNA und dem kollektiven Produktionsprozess von Wissen in der aDNA-Forschung.
- Published
- 2017
48. De ce Vestul deține încă supremația și ce ne spune istoria despre viitor
- Author
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Moris Ian and Moris Ian
- Abstract
La începutul secolului XXI, mulți analiști consideră că ascensiunea unor puteri precum China sau India înseamnă sfîrșitul dominației Vestului. Pentru a înțelege mai bine acest viitor posibil, trebuie să ne întoarcem în trecut. Ian Morris susține că explicația supremației Vestului în ultimii 200 de ani nu trebuie căutată în diferențele rasiale sau culturale, nici în realizările marilor personalități ce au marcat istoria, ci mai curînd în impactul pe care geografia l-a avut asupra eforturilor de adaptare ale oamenilor obișnuiți, pe măsură ce aceștia s-au confruntat cu lipsa resurselor, cu epidemii sau migrații devastatoare și cu ostilitatea climatului. Solid documentată și bazîndu-se pe cele mai recente descoperiri din variate domenii, De ce Vestul deține încă supremația ne poartă de-a lungul a 50.000 de ani de istorie, în încercarea de a explica motivele care au determinat poziția dominantă a Vestului și de a formula predicții cu privire la ce ne rezervă viitorul în următorul secol. Din cuprins: Configurația istoriei - Lene, teamă și lăcomie - Înainte de Est și Vest - Vestul preia conducerea - Grădina Edenului - Predestinare - Măsurarea trecutului - Estul recuperează decalajul - Cavalerii Apocalipsei - Umăr la umăr - Declinul și prăbușirea - Noua ordine mondială - Epoca Estului - Globalizarea - Arme, microbi și fontă - Vestul recuperează decalajul - Epoca Vestului - Războaiele mondiale - Epoca abundenței - De ce Vestul deține supremația... -...Deocamdată
- Published
- 2016
49. Biological Anthropology : The Natural History of Humankind
- Author
-
Craig Stanford, John S. Allen, Susan C. Anton, Craig Stanford, John S. Allen, and Susan C. Anton
- Abstract
For courses in Biological Anthropology Present a rich overview of biological anthropology, from early foundations to recent innovations Biological Anthropology: The Natural History of Humankind combines comprehensive coverage of the foundations of the field with modern innovations and discoveries, helping students understand, and get excited about, the discipline. Because the authors conduct research in three of the main areas of biological anthropology–the human fossil record (Susan Antón), primate behavior and ecology (Craig Stanford), and human biology and the brain (John Allen)–they offer a specialist approach that engages students and gives them everything they need to master the subject. The Fourth Edition continues to present traditional physical anthropology within a modern Darwinian framework, and includes coverage of contemporary discoveries to highlight the ever-increasing body of knowledge in biological anthropology. Also available with MyAnthroLab® MyAnthroLab for the Biological Anthropology course extends learning online to engage students and improve results. Media resources with assignments bring concepts to life, and offer students opportunities to practice applying what they've learned. Please note: this version of MyAnthroLab does not include an eText. Biological Anthropology: The Natural History of Humankind, Fourth Edition is also available via REVEL™, an interactive learning environment that enables students to read, practice, and study in one continuous experience. Note: You are purchasing a standalone product; MyLab™ & Mastering™ does not come packaged with this content. Students, if interested in purchasing this title with MyLab & Mastering, ask your instructor for the correct package ISBN and Course ID. Instructors, contact your Pearson representative for more information. If you would like to purchase both the physical text and MyLab & Mastering, search for: 013437794X / 9780134377940 Biological Anthropology: The Natural History of Humankind plus MyAnthroLab for Biological Anthropology – Access Card Package, 4/e Package consists of: 0134005694 / 9780134005690 Biological Anthropology: The Natural History of Humankind, 4/e 0134324404 / 9780134324401 MyAnthroLab for Biological Anthropology Access Card
- Published
- 2016
50. Searching for Adam : Genesis & the Truth About Man's Origin
- Author
-
Dr. Terry Mortenson and Dr. Terry Mortenson
- Subjects
- Religion and science, Life--Origin--Religious aspects, Creationism--Religious aspects
- Abstract
Though there are a growing number of books out on Adam, this one is unique with its multi-author combination of biblical, historical, theological, scientific, archaeological, and ethical arguments in support of believing in a literal Adam and the Fall. A growing number of professing evangelical leaders and scholars are doubting or denying a literal Adam and a literal Fall, which thereby undermines the gospel of Jesus Christ, the Last Adam, who came to undo the damaging consequences of Adam's sin and restore us to a right relationship with our Creator. This book is increase your confidence in the truth of Genesis 1–11 and the gospel! Enhance your understanding pertaining to the biblical evidence for taking Genesis as literal history Discover the scientific evidence from genetics, fossils, and human anatomy for the Bible's teaching about Adam Understand the moral, spiritual, and gospel reasons why belief in a literal Adam and Fall are essential for Christian orthodoxy
- Published
- 2016
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