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10 results on '"Grove, James C. R."'

5. Rapid deployment of SARS-CoV-2 testing: The CLIAHUB

Author

Crawford, Emily D., primary, Acosta, Irene, additional, Ahyong, Vida, additional, Anderson, Erika C., additional, Arevalo, Shaun, additional, Asarnow, Daniel, additional, Axelrod, Shannon, additional, Ayscue, Patrick, additional, Azimi, Camillia S., additional, Azumaya, Caleigh M., additional, Bachl, Stefanie, additional, Bachmutsky, Iris, additional, Bhaduri, Aparna, additional, Brown, Jeremy Bancroft, additional, Batson, Joshua, additional, Behnert, Astrid, additional, Boileau, Ryan M., additional, Bollam, Saumya R., additional, Bonny, Alain R., additional, Booth, David, additional, Borja, Michael Jerico B., additional, Brown, David, additional, Buie, Bryan, additional, Burnett, Cassandra E., additional, Byrnes, Lauren E., additional, Cabral, Katelyn A., additional, Cabrera, Joana P., additional, Caldera, Saharai, additional, Canales, Gabriela, additional, Castañeda, Gloria R., additional, Chan, Agnes Protacio, additional, Chang, Christopher R., additional, Charles-Orszag, Arthur, additional, Cheung, Carly, additional, Chio, Unseng, additional, Chow, Eric D., additional, Citron, Y. Rose, additional, Cohen, Allison, additional, Cohn, Lillian B., additional, Chiu, Charles, additional, Cole, Mitchel A., additional, Conrad, Daniel N., additional, Constantino, Angela, additional, Cote, Andrew, additional, Crayton-Hall, Tre’Jon, additional, Darmanis, Spyros, additional, Detweiler, Angela M., additional, Dial, Rebekah L., additional, Dong, Shen, additional, Duarte, Elias M., additional, Dynerman, David, additional, Egger, Rebecca, additional, Fanton, Alison, additional, Frumm, Stacey M., additional, Fu, Becky Xu Hua, additional, Garcia, Valentina E., additional, Garcia, Julie, additional, Gladkova, Christina, additional, Goldman, Miriam, additional, Gomez-Sjoberg, Rafael, additional, Gordon, M. Grace, additional, Grove, James C. R., additional, Gupta, Shweta, additional, Haddjeri-Hopkins, Alexis, additional, Hadley, Pierce, additional, Haliburton, John, additional, Hao, Samantha L., additional, Hartoularos, George, additional, Herrera, Nadia, additional, Hilberg, Melissa, additional, Ho, Kit Ying E., additional, Hoppe, Nicholas, additional, Hosseinzadeh, Shayan, additional, Howard, Conor J., additional, Hussmann, Jeffrey A., additional, Hwang, Elizabeth, additional, Ingebrigtsen, Danielle, additional, Jackson, Julia R., additional, Jowhar, Ziad M., additional, Kain, Danielle, additional, Kim, James Y. S., additional, Kistler, Amy, additional, Kreutzfeld, Oriana, additional, Kulsuptrakul, Jessie, additional, Kung, Andrew F., additional, Langelier, Charles, additional, Laurie, Matthew T., additional, Lee, Lena, additional, Leng, Kun, additional, Leon, Kristoffer E., additional, Leonetti, Manuel D., additional, Levan, Sophia R., additional, Li, Sam, additional, Li, Aileen W., additional, Liu, Jamin, additional, Lubin, Heidi S., additional, Lyden, Amy, additional, Mann, Jennifer, additional, Mann, Sabrina, additional, Margulis, Gorica, additional, Marquez, Diana M., additional, Marsh, Bryan P., additional, Martyn, Calla, additional, McCarthy, Elizabeth E., additional, McGeever, Aaron, additional, Merriman, Alexander F., additional, Meyer, Lauren K., additional, Miller, Steve, additional, Moore, Megan K., additional, Mowery, Cody T., additional, Mukhtar, Tanzila, additional, Mwakibete, Lusajo L., additional, Narez, Noelle, additional, Neff, Norma F., additional, Osso, Lindsay A., additional, Oviedo, Diter, additional, Peng, Suping, additional, Phelps, Maira, additional, Phong, Kiet, additional, Picard, Peter, additional, Pieper, Lindsey M., additional, Pincha, Neha, additional, Pisco, Angela Oliveira, additional, Pogson, Angela, additional, Pourmal, Sergei, additional, Puccinelli, Robert R., additional, Puschnik, Andreas S., additional, Rackaityte, Elze, additional, Raghavan, Preethi, additional, Raghavan, Madhura, additional, Reese, James, additional, Replogle, Joseph M., additional, Retallack, Hanna, additional, Reyes, Helen, additional, Rose, Donald, additional, Rosenberg, Marci F., additional, Sanchez-Guerrero, Estella, additional, Sattler, Sydney M., additional, Savy, Laura, additional, See, Stephanie K., additional, Sellers, Kristin K., additional, Serpa, Paula Hayakawa, additional, Sheehy, Maureen, additional, Sheu, Jonathan, additional, Silas, Sukrit, additional, Streithorst, Jessica A., additional, Strickland, Jack, additional, Stryke, Doug, additional, Sunshine, Sara, additional, Suslow, Peter, additional, Sutanto, Renaldo, additional, Tamura, Serena, additional, Tan, Michelle, additional, Tan, Jiongyi, additional, Tang, Alice, additional, Tato, Cristina M., additional, Taylor, Jack C., additional, Tenvooren, Iliana, additional, Thompson, Erin M., additional, Thornborrow, Edward C., additional, Tse, Eric, additional, Tung, Tony, additional, Turner, Marc L., additional, Turner, Victoria S., additional, Turnham, Rigney E., additional, Turocy, Mary J., additional, Vaidyanathan, Trisha V., additional, Vainchtein, Ilia D., additional, Vanaerschot, Manu, additional, Vazquez, Sara E., additional, Wandler, Anica M., additional, Wapniarski, Anne, additional, Webber, James T., additional, Weinberg, Zara Y., additional, Westbrook, Alexandra, additional, Wong, Allison W., additional, Wong, Emily, additional, Worthington, Gajus, additional, Xie, Fang, additional, Xu, Albert, additional, Yamamoto, Terrina, additional, Yang, Ying, additional, Yarza, Fauna, additional, Zaltsman, Yefim, additional, Zheng, Tina, additional, and DeRisi, Joseph L., additional

Published
2020
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8. Novel hybrid action of GABA mediates inhibitory feedback in the mammalian retina.

Author

de los Santos, Janira, Purohit, Shashvat, Grove, James C. R., Hirano, Arlene A., Brecha, Nicholas C., Barnes, Steven, McHugh, Cyrus F., and Field, Greg D.

Subjects
GABA, RETINAL cone photoreceptor cells, GABA receptors, HYDROGEN-ion concentration, SYNAPSES
Abstract

The stream of visual information sent from photoreceptors to second-order bipolar cells is intercepted by laterally interacting horizontal cells that generate feedback to optimize and improve the efficiency of signal transmission. The mechanisms underlying the regulation of graded photoreceptor synaptic output in this nonspiking network have remained elusive. Here, we analyze with patch clamp recording the novel mechanisms by which horizontal cells control pH in the synaptic cleft to modulate photoreceptor neurotransmitter release. First, we show that mammalian horizontal cells respond to their own GABA release and that the results of this autaptic action affect cone voltage-gated Ca2+ channel (CaV channel) gating through changes in pH. As a proof-of-principle, we demonstrate that chemogenetic manipulation of horizontal cells with exogenous anion channel expression mimics GABA-mediated cone CaV channel inhibition. Activation of these GABA receptor anion channels can depolarize horizontal cells and increase cleft acidity via Na+/H+ exchanger (NHE) proton extrusion, which results in inhibition of cone CaV channels. This action is effectively counteracted when horizontal cells are sufficiently hyperpolarized by increased GABA receptor (GABAR)-mediated HCO3− efflux, alkalinizing the cleft and disinhibiting cone CaV channels. This demonstrates how hybrid actions of GABA operate in parallel to effect voltage-dependent pH changes, a novel mechanism for regulating synaptic output. [ABSTRACT FROM AUTHOR]

Published
2019
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10. Dopamine D1 receptor modulation of calcium channel currents in horizontal cells of mouse retina.

Author

Xue Liu, Grove, James C. R., Hirano, Arlene A., Brecha, Nicholas C., and Barnes, Steven

Subjects
*DOPAMINE, *CALCIUM channels, *CIRCADIAN rhythms, *DOPAMINERGIC mechanisms, *GUANOSINE
Abstract

Horizontal cells form the first laterally interacting network of inhibitory interneurons in the retina. Dopamine released onto horizontal cells under photic and circadian control modulates horizontal cell function. Using isolated, identified horizontal cells from a connexin-57-iCre × ROSA26-tdTomato transgenic mouse line, we investigated dopaminergic modulation of calcium channel currents (ICa) with whole cell patch-clamp techniques. Dopamine (10 μM) blocked 27% of steadystate ICa, an action blunted to 9% in the presence of the L-type Ca channel blocker verapamil (50 μM). The dopamine type 1 receptor (D1R) agonist SKF38393 (20 μM) inhibited ICa by 24%. The D1R antagonist SCH23390 (20 μM) reduced dopamine and SKF38393 inhibition. Dopamine slowed ICa activation, blocking ICa by 38% early in a voltage step. Enhanced early inhibition of ICa was eliminated by applying voltage prepulses to +120 mV for 100 ms, increasing ICa by 31% and 11% for early and steady-state currents, respectively. Voltage-dependent facilitation of ICa and block of dopamine inhibition after preincubation with a Gβγ-blocking peptide suggested involvement of Gβγ proteins in the D1R-mediated modulation. When the G protein activator guanosine 5'-O-(3-thiotriphosphate) (GTPγS) was added intracellularly, ICa was smaller and showed the same slowed kinetics seen during D1R activation. With GTPγS in the pipette, additional block of ICa by dopamine was only 6%. Strong depolarizing voltage prepulses restored the GTPγS-reduced early ICa amplitude by 36% and steady-state ICa amplitude by 3%. These results suggest that dopaminergic inhibition of ICa via D1Rs is primarily mediated through the action of Gβγ proteins in horizontal cells. [ABSTRACT FROM AUTHOR]

Published
2016
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