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1. Measurement and analysis of the $^{246}$Cm and $^{248}$Cm neutron capture cross-sections at the EAR2 of the n TOF facility

Author: Alcayne, V., Kimura, A., Mendoza, E., Cano-Ott, D., Aberle, O., Álvarez-Velarde, F., Amaducci, S., Andrzejewski, J., Audouin, L., Bécares, V., Babiano-Suarez, V., Bacak, M., Barbagallo, M., Bečvář, F., Bellia, G., Berthoumieux, E., Billowes, J., Bosnar, D., Brown, A., Busso, M., Caamaño, M., Caballero-Ontanaya, L., Calviño, F., Calviani, M., Casanovas, A., Cerutti, F., Chen, Y. H., Chiaveri, E., Colonna, N., Cortés, G., Cortés-Giraldo, M. A., Cosentino, L., Cristallo, S., Damone, L. A., Diakaki, M., Dietz, M., Domingo-Pardo, C., Dressler, R., Dupont, E., Durán, I., Eleme, Z., Fernández-Domınguez, B., Ferrari, A., Finocchiaro, P., Furman, V., Göbel, K., Garg, R., Gawlik-Ramiega, A., Gilardoni, S., Glodariu, T., Gonçalves, I. F., González-Romero, E., Guerrero, C., Gunsing, F., Harada, H., Heinitz, S., Heyse, J., Jenkins, D. G., Jericha, E., Käppeler, F., Kadi, Y., Kivel, N., Kokkoris, M., Kopatch, Y., Krtička, M., Kurtulgil, D., Ladarescu, I., Lederer-Woods, C., Leeb, H., Lerendegui-Marco, J., Meo, S. Lo, Lonsdale, S. J., Macina, D., Manna, A., Martınez, T., Masi, A., Massimi, C., Mastinu, P., Mastromarco, M., Matteucci, F., Maugeri, E. A., Mazzone, A., Mengoni, A., Michalopoulou, V., Milazzo, P. M., Mingrone, F., Musumarra, A., Negret, A., Nolte, R., Ogállar, F., Oprea, A., Patronis, N., Pavlik, A., de Rada, A. Pérez, Perkowski, J., Persanti, L., Porras, I., Praena, J., Quesada, J. M., Radeck, D., Ramos-Doval, D., Rauscher, T., Reifarth, R., Rochman, D., Romanets, Y., Rubbia, C., Sabaté-Gilarte, M., Saxena, A., Schillebeeckx, P., Schumann, D., Smith, A. G., Sosnin, N. V., Stamatopoulos, A., Tagliente, G., Tain, J. L., Talip, T., Tarifeño-Saldivia, A., Tassan-Got, L., Torres-Sánchez, P., Tsinganis, A., Ulrich, J., Urlass, S., Valenta, S., Vannini, G., Variale, V., Vaz, P., Ventura, A., Vlachoudis, V., Vlastou, R., Wallner, A., Woods, P. J., Wright, T., and Žugec, P.
Subjects: Nuclear Experiment
Abstract: The $^{246}$Cm(n,$\gamma$) and $^{248}$Cm(n,$\gamma$) cross-sections have been measured at the Experimental Area 2 (EAR2) of the n_TOF facility at CERN with three C$_6$D$_6$ detectors. This measurement is part of a collective effort to improve the capture cross-section data for Minor Actinides (MAs), which are required to estimate the production and transmutation rates of these isotopes in light water reactors and innovative reactor systems. In particular, the neutron capture in $^{246}$Cm and $^{248}$Cm open the path for the formation of other Cm isotopes and heavier elements such as Bk and Cf and the knowledge of (n,$\gamma$) cross-sections of these Cm isotopes plays an important role in the transport, transmutation and storage of the spent nuclear fuel. The reactions $^{246}$Cm(n,$\gamma$) and $^{248}$Cm(n,$\gamma$) have been the two first capture measurements analyzed at n_TOF EAR2. Until this experiment and two recent measurements performed at J-PARC, there was only one set of data of the capture cross-sections of $^{246}$Cm and $^{248}$Cm, that was obtained in 1969 in an underground nuclear explosion experiment. In the measurement at n_TOF a total of 13 resonances of $^{246}$Cm between 4 and 400 eV and 5 of $^{248}$Cm between 7 and 100 eV have been identified and fitted. The radiative kernels obtained for $^{246}$Cm are compatible with JENDL-5, but some of them are not with JENDL-4, which has been adopted by JEFF-3.3 and ENDF/B-VIII.0. The radiative kernels obtained for the first three $^{248}$Cm resonances are compatible with JENDL-5, however, the other two are not compatible with any other evaluation and are 20% and 60% larger than JENDL-5.
Published: 2024

2. Measurement of the $^{14}$N(n,p)$^{14}$C cross section at the CERN n_TOF facility from sub-thermal energy to 800 keV

Author: Torres-Sánchez, P., Praena, J., Porras, I., Sabaté-Gilarte, M., Lederer-Woods, C., Aberle, O., Alcayne, V., Amaducci, S., Andrzejewski, J., Audouin, L., Bécares, V., Babiano-Suarez, V., Bacak, M., Barbagallo, M., Bečvář, F., Bellia, G., Berthoumieux, E., Billowes, J., Bosnar, D., Brown, A., Busso, M., Caamaño, M., Caballero, L., Calviño, F., Calviani, M., Cano-Ott, D., Casanovas, A., Cerutti, F., Chen, Y. H., Chiaveri, E., Colonna, N., Cortés, G., Cortés-Giraldo, M. A., Cosentino, L., Cristallo, S., Damone, L. A., Diakaki, M., Dietz, M., Domingo-Pardo, C., Dressler, R., Dupont, E., Durán, I., Eleme, Z., Fernández-Domínguez, B., Ferrari, A., Ferrer, F. J., Finocchiaro, P., Furman, V., Göbel, K., Garg, R., Gawlik-Ramięga, A., Geslot, B., Gilardoni, S., Glodariu, T., Gonçalves, I. F., González-Romero, E., Guerrero, C., Gunsing, F., Harada, H., Heinitz, S., Heyse, J., Jenkins, D. G., Jericha, E., Käppeler, F., Kadi, Y., Kimura, A., Kivel, N., Kokkoris, M., Kopatch, Y., Krtička, M., Kurtulgil, D., Ladarescu, I., Leeb, H., Lerendegui-Marco, J., Meo, S. Lo, Lonsdale, S. J., Macina, D., Manna, A., Martínez, T., Masi, A., Massimi, C., Mastinu, P., Mastromarco, M., Matteucci, F., Maugeri, E. A., Mazzone, A., Mendoza, E., Mengoni, A., Michalopoulou, V., Milazzo, P. M., Mingrone, F., Musumarra, A., Negret, A., Nolte, R., Ogállar, F., Oprea, A., Patronis, N., Pavlik, A., Perkowski, J., Piersanti, L., Quesada, J. M., Radeck, D., Ramos-Doval, D., Rauscher, T., Reifarth, R., Rochman, D., Rubbia, C., Saxena, A., Schillebeeckx, P., Schumann, D., Smith, A. G., Sosnin, N. V., Stamatopoulos, A., Tagliente, G., Tain, J. L., Talip, T., Tarifeño-Saldivia, A., Tassan-Got, L., Tsinganis, A., Ulrich, J., Urlass, S., Valenta, S., Vannini, G., Variale, V., Vaz, P., Ventura, A., Vlachoudis, V., Vlastou, R., Wallner, A., Woods, P. J., Wright, T., and Žugec, P.
Subjects: Nuclear Experiment
Abstract: Background: The $^{14}$N(n,p)$^{14}$C reaction is of interest in neutron capture therapy, where nitrogen-related dose is the main component due to low-energy neutrons, and in astrophysics, where 14N acts as a neutron poison in the s-process. Several discrepancies remain between the existing data obtained in partial energy ranges: thermal energy, keV region and resonance region. Purpose: Measuring the 14N(n,p)14C cross section from thermal to the resonance region in a single measurement for the first time, including characterization of the first resonances, and providing calculations of Maxwellian averaged cross sections (MACS). Method: Time-of-flight technique. Experimental Area 2 (EAR-2) of the neutron time-of-flight (n_TOF) facility at CERN. $^{10}$B(n,${\alpha}$)$^7$Li and $^{235}$U(n,f) reactions as references. Two detection systems running simultaneously, one on-beam and another off-beam. Description of the resonances with the R-matrix code sammy. Results: The cross section has been measured from sub-thermal energy to 800 keV resolving the two first resonances (at 492.7 and 644 keV). A thermal cross-section (1.809$\pm$0.045 b) lower than the two most recent measurements by slightly more than one standard deviation, but in line with the ENDF/B-VIII.0 and JEFF-3.3 evaluations has been obtained. A 1/v energy dependence of the cross section has been confirmed up to tens of keV neutron energy. The low energy tail of the first resonance at 492.7 keV is lower than suggested by evaluated values, while the overall resonance strength agrees with evaluations. Conclusions: Our measurement has allowed to determine the $^{14}$N(n,p) cross-section over a wide energy range for the first time. We have obtained cross-sections with high accuracy (2.5 %) from sub-thermal energy to 800 keV and used these data to calculate the MACS for kT = 5 to kT = 100 keV., Comment: 18 pages, 15 figures, 4 tables
Published: 2022
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3. High accuracy, high resolution 235U(n,f) cross section from n_TOF (CERN) in the thermal to 10 keV energy range

Author: collaboration, n_TOF, Mastromarco, M., Amaducci, S., Colonna, N., Finocchiaro, P., Cosentino, L., Aberle, O., Andrzejewski, J., Audouin, L., Bacak, M., Balibrea, J., Barbagallo, M., Bečvář, F., Berthoumieux, E., Billowes, J., Bosnar, D., Brown, A., Caamaño, M., Calviño, F., Calviani, M., Cano-Ott, D., Cardella, R., Casanovas, A., Cerutti, F., Chen, Y. H., Chiaveri, E., Cortés, G., Cortés-Giraldo, M. A., Damone, L. A., Diakaki, M., Domingo-Pardo, C., Dressler, R., Dupont, E., Durán, I., Fernández-Domínguez, B., Ferrari, A., Ferreira, P., Furman, V., Göbel, K., García, A. R., Gawlik, A., Gilardoni, S., Glodariu, T., Gonçalves, I. F., González-Romero, E., Griesmayer, E., Guerrero, C., Gunsing, F., Harada, H., Heinitz, S., Heyse, J., Jenkins, D. G., Jericha, E., Käppeler, F., Kadi, Y., Kalamara, A., Kavrigin, P., Kimura, A., Kivel, N., Knapova, I., Kokkoris, M., Krtička, M., Kurtulgil, D., Leal-Cidoncha, E., Lederer, C., Leeb, H., Lerendegui-Marco, J., Meo, S. Lo, Lonsdale, S. J., Macina, D., Manna, A., Marganiec, J., Martínez, T., Masi, A., Massimi, C., Mastinu, P., Maugeri, E. A., Mazzone, A., Mendoza, E., Mengoni, A., Milazzo, P. M., Mingrone, F., Musumarra, A., Negret, A., Nolte, R., Oprea, A., Patronis, N., Pavlik, A., Perkowski, J., Porras, I., Praena, J., Quesada, J. M., Radeck, D., Rauscher, T., Reifarth, R., Rubbia, C., Ryan, J. A., Sabaté-Gilarte, M., Saxena, A., Schillebeeckx, P., Schumann, D., Sedyshev, P., Smith, A. G., Sosnin, N. V., Stamatopoulos, A., Tagliente, G., Tain, J. L., Tarifeño-Saldivia, A., Tassan-Got, L., Valenta, S., Vannini, G., Variale, V., Vaz, P., Ventura, A., Vlachoudis, V., Vlastou, R., Wallner, A., Warren, S., Weiss, C., Woods, P. J., Wright, T., and Žugec, P.
Subjects: Nuclear Experiment
Abstract: The 235U(n,f) cross section was measured in a wide energy range (25 meV - 170 keV) at the n_TOF facility at CERN, relative to 6Li(n,t) and 10B(n,alpha) standard reactions, with high resolution and accuracy, with a setup based on a stack of six samples and six silicon detectors placed in the neutron beam. In this paper we report on the results in the region between thermal and 10 keV neutron energy. A resonance analysis has been performed up to 200 eV, with the code SAMMY. The resulting fission kernels are compared with the ones extracted on the basis of the resonance parameters of the most recent major evaluated data libraries. A comparison of the n_TOF data with the evaluated cross sections is also performed from thermal to 10 keV neutron energy for the energy-averaged cross section in energy groups of suitably chosen width. A good agreement is found in average between the new results and the latest evaluated data files ENDF-B/VIII and JEFF-3.3, as well as with respect to the IAEA reference files. However, some discrepancies are still present in some specific energy regions. The new dataset here presented, characterized by unprecedented resolution and accuracy, can help improving the evaluations in the Resolved Resonance Region and up to 10 keV, and reduce the uncertainties that affect this region.
Published: 2022

4. Imaging neutron capture cross sections: i-TED proof-of-concept and future prospects based on Machine-Learning techniques

Author: Babiano-Suárez, V., Lerendegui-Marco, J., Balibrea-Correa, J., Caballero, L., Calvo, D., Ladarescu, I., Domingo-Pardo, C., Calviño, F., Casanovas, A., Tarifeño-Saldivia, A., Alcayne, V., Guerrero, C., Millán-Callado, M. A., González, M. T. Rodríguez, Barbagallo, M., Aberle, O., Amaducci, S., Andrzejewski, J., Audouin, L., Bacak, M., Bennett, S., Berthoumieux, E., Billowes, J., Bosnar, D., Brown, A., Busso, M., Caamaño, M., Calviani, M., Cano-Ott, D., Cerutti, F., Chiaveri, E., Colonna, N., Cortés, G., Cortés-Giraldo, M. A., Cosentino, L., Cristallo, S., Damone, L. A., Davies, P. J., Diakaki, M., Dietz, M., Dressler, R., Ducasse, Q., Dupont, E., Durán, I., Eleme, Z., Fern\', B., ez-Domínguez, Ferrari, A., Finocchiaro, P., Furman, V., Göbel, K., Garg, R., Gawlik, A., Gilardoni, S., Gonçalves, I. F., González-Romero, E., Gunsing, F., Harada, H., Heinitz, S., Heyse, J., Jenkins, D. G., Junghans, A., Käppeler, F., Kadi, Y., Kimura, A., Knapova, I., Kokkoris, M., Kopatch, Y., Krtička, M., Kurtulgil, D., Lederer-Woods, C., Leeb, H., Lonsdale, S. J., Macina, D., Manna, A., Martinez, T., Masi, A., Massimi, C., Mastinu, P., Mastromarco, M., Maugeri, E. A., Mazzone, A., Mendoza, E., Mengoni, A., Michalopoulou, V., Milazzo, P. M., Mingrone, F., Moreno-Soto, J., Musumarra, A., Negret, A., Ogállar, F., Oprea, A., Patronis, N., Pavlik, A., Perkowski, J., Persanti, L., Petrone, C., Pirovano, E., Porras, I., Praena, J., Quesada, J. M., Ramos-Doval, D., Rauscher, T., Reifarth, R., Rochman, D., Rubbia, C., Sabaté-Gilarte, M., Saxena, A., Schillebeeckx, P., Schumann, D., Sekhar, A., Smith, A. G., Sosnin, N. V., Sprung, P., Stamatopoulos, A., Tagliente, G., Tain, J. L., Tassan-Got, L., Thomas, Th., Torres-Sánchez, P., Tsinganis, A., Ulrich, J., Urlass, S., Valenta, S., Vannini, G., Variale, V., Vaz, P., Ventura, A., Vescovi, D., Vlachoudis, V., Vlastou, R., Wallner, A., Woods, P. J., Wright, T., and Žugec, P.
Subjects: Physics - Instrumentation and Detectors, Astrophysics - Instrumentation and Methods for Astrophysics, Nuclear Experiment
Abstract: i-TED is an innovative detection system which exploits Compton imaging techniques to achieve a superior signal-to-background ratio in ($n,\gamma$) cross-section measurements using time-of-flight technique. This work presents the first experimental validation of the i-TED apparatus for high-resolution time-of-flight experiments and demonstrates for the first time the concept proposed for background rejection. To this aim both $^{197}$Au($n,\gamma$) and $^{56}$Fe($n, \gamma$) reactions were measured at CERN n\_TOF using an i-TED demonstrator based on only three position-sensitive detectors. Two \cds detectors were also used to benchmark the performance of i-TED. The i-TED prototype built for this study shows a factor of $\sim$3 higher detection sensitivity than state-of-the-art \cds detectors in the $\sim$10~keV neutron energy range of astrophysical interest. This paper explores also the perspectives of further enhancement in performance attainable with the final i-TED array consisting of twenty position-sensitive detectors and new analysis methodologies based on Machine-Learning techniques., Comment: 16 pages, 16 figures
Published: 2020
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5. Review and new concepts for neutron-capture measurements of astrophysical interest

Author: Domingo-Pardo, C., Babiano-Suarez, V., Balibrea-Correa, J., Caballero, L., Ladarescu, I., Lerendegui-Marco, J., Tain, J. L., Calviño, F., Casanovas, A., Segarra, A., Tarifeño-Saldivia, A. E., Guerrero, C., Millán-Callado, M. A., Quesada, J. M., Rodríguez-González, M. T., Aberle, O., Alcayne, V., Amaducci, S., Andrzejewski, J., Audouin, L., Bacak, M., Barbagallo, M., Bennett, S., Berthoumieux, E., Bosnar, D., Brown, A. S., Busso, M., Caamaño, M., Calviani, M., Cano-Ott, D., Cerutti, F., Chiaveri, E., Colonna, N., Cortés, G. P., Cortés-Giraldo, M. A., Cosentino, L., Cristallo, S., Damone, L. A., Davies, P. J., Diakaki, M., Dietz, M., Dressler, R., Ducasse, Q., Dupont, E., Durán, I., Eleme, Z., Fernández-Domíngez, B., Ferrari, A., Ferro-Goncalves, I., Finocchiaro, P., Furman, V., Garg, R., Gawlik, A., Gilardoni, S., Göbel, K., González-Romero, E., Gunsing, F., Heyse, J., Jenkins, D. G., Jericha, E., Jiri, U., Junghans, A., Kadi, Y., Käppeler, F., Kimura, A., Knapová, I., Kokkoris, M., Kopatch, Y., Krtička, M., Kurtulgil, D., Lederer-Woods, C., Lonsdale, S. -J., Macina, D., Manna, A., Martínez, T., Masi, A., Massimi, C., Mastinu, P. F., Mastromarco, M., Maugeri, E., Mazzone, A., Mendoza, E., Mengoni, A., Michalopoulou, V., Milazzo, P. M., Mingrone, F., Moreno-Soto, J., Musumarra, A., Negret, A., Ogállar, F., Oprea, A., Patronis, N., Pavlik, A., Perkowski, J., Petrone, C., Piersanti, L., Pirovano, E., Porras, I., Praena, J., Doval, D. Ramos, Reifarth, R., Rochman, D., Rubbia, C., Sabaté-Gilarte, M., Saxena, A., Schillebeeckx, P., Schumann, D., Sekhar, A., Smith, A. G., Sosnin, N., Sprung, P., Stamatopoulos, A., Tagliente, G., Tassan-Got, L., Thomas, B., Torres-Sánchez, P., Tsinganis, A., Urlass, S., Valenta, S., Vannini, G., Variale, V., Vaz, P., Ventura, A., Vescovi, D., Vlachoudis, V., Vlastou, R., Wallner, A., Woods, P. J., Wright, T. J., Zugec, P. v, and Collaboration, The n_TOF
Subjects: Physics - Instrumentation and Detectors
Abstract: The idea of slow-neutron capture nucleosynthesis formulated in 1957 triggered a tremendous experimental effort in different laboratories worldwide to measure the relevant nuclear physics input quantities, namely ($n,\gamma$) cross sections over the stellar temperature range (from few eV up to several hundred keV) for most of the isotopes involved from Fe up to Bi. A brief historical review focused on total energy detectors will be presented to illustrate how, advances in instrumentation have led, over the years, to the assessment and discovery of many new aspects of $s$-process nucleosynthesis and to the progressive refinement of theoretical models of stellar evolution. A summary will be presented on current efforts to develop new detection concepts, such as the Total-Energy Detector with $\gamma$-ray imaging capability (i-TED). The latter is based on the simultaneous combination of Compton imaging with neutron time-of-flight (TOF) techniques, in order to achieve a superior level of sensitivity and selectivity in the measurement of stellar neutron capture rates., Comment: Nuclear Physics in Astrophysics IX - Conference Proceedings
Published: 2019
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6. Measurement of the 235U(n,f) cross section relative to the 6Li(n,t) and 10B(n,alpha) standards from thermal to 170 keV neutron energy range at n_TOF

Author: Amaducci, S., Cosentino, L., Barbagallo, M., Colonna, N., Mengoni, A., Massimi, C., Meo, S. Lo, Finocchiaro, P., Aberle, O., Andrzejewski, J., Audouin, L., Bacak, M., Balibrea, J., Bečvář, F., Berthoumieux, E., Billowes, J., Bosnar, D., Brown, A., Caamaño, M., Calviño, F., Calviani, M., Cano-Ott, D., Cardella, R., Casanovas, A., Cerutti, F., Chen, Y. H., Chiaveri, E., Cortés, G., Cortés-Giraldo, M. A., Damone, L. A., Diakaki, M., Domingo-Pardo, C., Dressler, R., Dupont, E., Durán, I., Fernández-Domínguez, B., Ferrari, A., Ferreira, P., Furman, V., Göbel, K., García, A. R., Gawlik, A., Gilardoni, S., Glodariu, T., Gonçalves, I. F., González-Romero, E., Griesmayer, E., Guerrero, C., Gunsing, F., Harada, H., Heinitz, S., Heyse, J., Jenkins, D. G., Jericha, E., Käppeler, F., Kadi, Y., Kalamara, A., Kavrigin, P., Kimura, A., Kivel, N., Knapova, I., Kokkoris, M., Krtička, M., Kurtulgil, D., Leal-Cidoncha, E., Lederer, C., Leeb, H., Lerendegui-Marco, J., Lonsdale, S. J., Macina, D., Manna, A., Marganiec, J., Martínez, T., Masi, A., Mastinu, P., Mastromarco, M., Maugeri, E. A., Mazzone, A., Mendoza, E., Milazzo, P. M., Mingrone, F., Musumarra, A., Negret, A., Nolte, R., Oprea, A., Patronis, N., Pavlik, A., Perkowski, J., Porras, I., Praena, J., Quesada, J. M., Radeck, D., Rauscher, T., Reifarth, R., Rubbia, C., Ryan, J. A., Sabaté-Gilarte, M., Saxena, A., Schillebeeckx, P., Schumann, D., Sedyshev, P., Smith, A. G., Sosnin, N. V., Stamatopoulos, A., Tagliente, G., Tain, J. L., Tarifeño-Saldivia, A., Tassan-Got, L., Valenta, S., Vannini, G., Variale, V., Vaz, P., Ventura, A., Vlachoudis, V., Vlastou, R., Wallner, A., Warren, S., Weiss, C., Woods, P. J., Wright, T., and Žugec, P.
Subjects: Nuclear Experiment, High Energy Physics - Experiment
Abstract: The 235U(n,f) cross section was measured in a wide energy range at n_TOF relative to 6Li(n,t) and 10B(n,alpha), with high resolution and in a wide energy range, with a setup based on a stack of six samples and six silicon detectors placed in the neutron beam. This allowed us to make a direct comparison of the reaction yields under the same experimental conditions, and taking into account the forward/backward emission asymmetry. A hint of an anomaly in the 10{\div}30 keV neutron energy range had been previously observed in other experiments, indicating a cross section systematically lower by several percent relative to major evaluations. The present results indicate that the evaluated cross section in the 9{\div}18 keV neutron energy range is indeed overestimated, both in the recent updates of ENDF/B-VIII.0 and of the IAEA reference data. Furthermore, these new high-resolution data confirm the existence of resonance-like structures in the keV neutron energy region. The new, high accuracy results here reported may lead to a reduction of the uncertainty in the 1{\div}100 keV neutron energy region. Finally, the present data provide additional confidence on the recently re-evaluated cross section integral between 7.8 and 11 eV., Comment: 22 pages, 20 figures, submitted to PRC
Published: 2019
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7. Modeling the performance of contact-separation triboelectric nanogenerators

Author: Callaty, C., Gonçalves, I., Rodrigues, C., and Ventura, J.
Published: 2023
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8. Fluid flow and heat transfer in microchannel devices for cooling applications: Experimental and numerical approaches

Author: Pontes, P., Gonçalves, I., Andredaki, M., Georgoulas, A., Moreira, A.L.N., and Moita, A.S.
Published: 2023
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9. The $^{7}$Be($\boldsymbol{n,p}$)$^{7}$Li reaction and the Cosmological Lithium Problem: measurement of the cross section in a wide energy range at n_TOF (CERN)

Author: Damone, L., Barbagallo, M., Mastromarco, M., Mengoni, A., Cosentino, L., Maugeri, E., Heinitz, S., Schumann, D., Dressler, R., Käppeler, F., Colonna, N., Finocchiaro, P., Andrzejewski, J., Perkowski, J., Gawlik, A., Aberle, O., Altstadt, S., Ayranov, M., Audouin, L., Bacak, M., Balibrea-Correa, J., Ballof, J., Bécares, V., Bečvář, F., Beinrucker, C., Bellia, G., Bernardes, A. P., Berthoumieux, E., Billowes, J., Borge, M. J. G., Bosnar, D., Brown, A., Brugger, M., Busso, M., Caamaño, M., Calviño, F., Calviani, M., Cano-Ott, D., Cardella, R., Casanovas, A., Castelluccio, D. M., Catherall, R., Cerutti, F., Chen, Y. H., Chiaveri, E., Cortés, G., Cortés-Giraldo, M. A., Cristallo, S., Diakaki, M., Dietz, M., Domingo-Pardo, C., Dorsival, A., Dupont, E., Duran, I., Fernandez-Dominguez, B., Ferrari, A., Ferreira, P., Furman, W., Ganesan, S., García-Rio, A., Gilardoni, S., Glodariu, T., Göbel, K., Gonçalves, I. F., González-Romero, E., Goodacre, T. D., Griesmayer, E., Guerrero, C., Gunsing, F., Harada, H., Heftrich, T., Heyse, J., Jenkins, D. G., Jericha, E., Johnston, K., Kadi, Y., Kalamara, A., Katabuchi, T., Kavrigin, P., Kimura, A., Kivel, N., Kohester, U., Kokkoris, M., Krtička, M., Kurtulgil, D., Leal-Cidoncha, E., Lederer-Woods, C., Leeb, H., Lerendegui-Marco, J., Meo, S. Lo, Lonsdale, S. J., Losito, R., Macina, D., Marganiec, J., Marsh, B., Martíne, T., Correia, J. G. Martins, Masi, A., Massimi, C., Mastinu, P., Matteucci, F., Mazzone, A., Mendoza, E., Milazzo, P. M., Mingrone, F., Mirea, M., Musumarra, A., Negret, A., Nolte, R., Oprea, A., Patronis, N., Pavlik, A., Piersanti, L., Piscopo, M., Plompen, A., Porras, I., Praena, J., Quesada, J. M., Radeck, D., Rajeev, K., Rauscher, T., Reifarth, R., Riego-Perez, A., Rothe, S., Rout, P., Rubbia, C., Ryan, J., Sabaté-Gilarte, M., Saxena, A., Schell, J., Schillebeeckx, P., Schmidt, S., Sedyshev, P., Seiffert, C., Smith, A. G., Sosnin, N. V., Stamatopoulos, A., Stora, T., Tagliente, G., Tain, J. L., Tarifeño-Saldivia, A., Tassan-Got, L., Tsinganis, A., Valenta, S., Vannini, G., Variale, V., Vaz, P., Ventura, A., Vlachoudis, V., Vlastou, R., Wallner, A., Warren, S., Weigand, M., Weiß, C., Wolf, C., Woods, P. J., Wright, T., and Žugec, P.
Subjects: Nuclear Experiment
Abstract: We report on the measurement of the $^{7}$Be($n, p$)$^{7}$Li cross section from thermal to approximately 325 keV neutron energy, performed in the high-flux experimental area (EAR2) of the n\_TOF facility at CERN. This reaction plays a key role in the lithium yield of the Big Bang Nucleosynthesis (BBN) for standard cosmology. The only two previous time-of-flight measurements performed on this reaction did not cover the energy window of interest for BBN, and showed a large discrepancy between each other. The measurement was performed with a Si-telescope, and a high-purity sample produced by implantation of a $^{7}$Be ion beam at the ISOLDE facility at CERN. While a significantly higher cross section is found at low-energy, relative to current evaluations, in the region of BBN interest the present results are consistent with the values inferred from the time-reversal $^{7}$Li($p, n$)$^{7}$Be reaction, thus yielding only a relatively minor improvement on the so-called Cosmological Lithium Problem (CLiP). The relevance of these results on the near-threshold neutron production in the p+$^{7}$Li reaction is also discussed.
Published: 2018
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10. Cross section measurements of $^{155,157}$Gd(n,$\gamma$) induced by thermal and epithermal neutrons

Author: Mastromarco, M., Manna, A., Aberle, O., Amaducci, S., Andrzejewski, J., Audouin, L., Bacak, M., Balibrea, J., Barbagallo, M., Becvar, F., Berthoumieux, E., Billowes, J., Bosnar, D., Brown, A., Caamano, M., Calvino, F., Calviani, M., Cano-Ott, D., Cardella, R., Casanovas, A., Castelluccio, D. M., Cerutti, F., Chen, Y. H., Chiaveri, E., Clai, G., Colonna, N., Cortes, G., Cortes-Giraldo, M. A., Cosentino, L., Damone, L. A., Diakaki, M., Dietz, M., Domingo-Pardo, C., Dressler, R., Dupont, E., Duran, I., Fernandez-Domnguez, B., Ferrari, A., Ferreira, P., Finocchiaro, P., Furman, V., Gobel, K., Garca, A. R., Gawlik, A., Gilardoni, S., Glodariu, T., Goncalves, I. F., Gonzalez-Romero, E., Griesmayer, E., Guerrero, C., Guglielmelli, A., Gunsing, F., Harada, H., Heinitz, S., Heyse, J., Jenkins, D. G., Jericha, E., Kaeppeler, F., Kadi, Y., Kalamara, A., Kavrigin, P., Kimura, A., Kivel, N., Kokkoris, M., Krticka, M., Kurtulgil, D., Leal-Cidoncha, E., Lederer-Woods, C., Leeb, H., Lerendegui-Marco, J., Lonsdale, S. J., Macina, D., Marganiec, J., Martnez, T., Masi, A., Massimi, C., Mastinu, P., Maugeri, E. A., Mazzone, A., Mendoza, E., Mengoni, A., Milazzo, P. M., Mingrone, F., Musumarra, A., Negret, A., Nolte, R., Oprea, A., Patronis, N., Pavlik, A., Perkowski, J., Porras, I., Praena, J., Quesada, J. M., Radeck, D., Rauscher, T., Reifarth, R., Rocchi, F., Rubbia, C., Ryan, J. A., Sabate-Gilarte, M., Saxena, A., Schillebeeckx, P., Schumann, D., Sedyshev, P., Smith, A. G., Sosnin, N. V., Stamatopoulos, A., Tagliente, G., Tain, J. L., Tarifeno-Saldivia, A., Tassan-Got, L., Valenta, S., Vannini, G., Variale, V., Vaz, P., Ventura, A., Vlachoudis, V., Vlastou, R., Wallner, A., Warren, S., Weiss, C., Woods, P. J., Wright, T., and Zugec, P.
Subjects: Nuclear Experiment
Abstract: Neutron capture measurements on $^{155}$Gd and $^{157}$Gd were performed using the time-of-flight technique at the n\_TOF facility at CERN. Four samples in form of self-sustaining metallic discs isotopically enriched in $^{155}$Gd and $^{157}$Gd were used. The measurements were carried out at the experimental area (EAR1) at 185 m from the neutron source, with an array of 4 C$_6$D$_6$ liquid scintillation detectors. The capture cross sections of $^{155}$Gd and $^{157}$Gd at neutron kinetic energy of 0.0253 eV have been estimated to be 62.2(2.2) kb and 239.8(9.3) kb, respectively, thus up to 6\% different relative to the ones reported in the nuclear data libraries. A resonance shape analysis has been performed in the resolved resonance region up to 180 eV and 300 eV, respectively, in average resonance parameters have been found in good agreement with evaluations. Above these energies the observed resonance-like structures in the cross section have been tentatively characterised in terms of resonance energy and area up to 1 keV.
Published: 2018
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11. Experimental setup and procedure for the measurement of the 7Be(n,p)7Li reaction at n_TOF

Author: Barbagallo, M., Andrzejewski, J., Mastromarco, M., Perkowski, J., Damone, L. A., Gawlik, A., Cosentino, L., Finocchiaro, P., Maugeri, E. A., Mazzone, A., Dressler, R., Heinitz, S., Kivel, N., Schumann, D., Colonna, N., Aberle, O., Amaducci, S., Audouin, L., Bacak, M., Balibrea, J., Bečvář, F., Bellia, G., Berthoumieux, E., Billowes, J., Bosnar, D., Brown, A., Caamaño, M., Calviño, F., Calviani, M., Cano-Ott, D., Cardella, R., Casanovas, A., Cerutti, F., Chen, Y. H., Chiaveri, E., Cortés, G., Cortés-Giraldo, M. A., Cristallo, S., Diakaki, M., Dietz, M., Domingo-Pardo, C., Dupont, E., Durán, I., Fernández-Domínguez, B., Ferrari, A., Ferreira, P., Furman, V., Göbel, K., García, A. R., Gilardoni, S., Glodariu, T., Gonçalves, I. F., González-Romero, E., Griesmayer, E., Guerrero, C., Gunsing, F., Harada, H., Heyse, J., Jenkins, D. G., Jericha, E., Johnston, K., Käppeler, F., Kadi, Y., Kalamara, A., Kavrigin, P., Kimura, A., Kokkoris, M., Krtička, M., Kurtulgil, D., Lederer, C., Leeb, H., Lerendegui-Marco, J., Meo, S. Lo, Lonsdale, S. J., Macina, D., Manna, A., Marganiec, J., Martínez, T., Martins-Correia, J. G., Masi, A., Massimi, C., Mastinu, P., Mendoza, E., Mengoni, A., Milazzo, P. M., Mingrone, F., Musumarra, A., Negret, A., Nolte, R., Oprea, A., Pappalardo, A. D., Patronis, N., Pavlik, A., Piscopo, M., Porras, I., Praena, J., Quesada, J. M., Radeck, D., Rauscher, T., Reifarth, R., Robles, M. S., Rubbia, C., Ryan, J. A., Sabaté-Gilarte, M., Saxena, A., Schell, J., Schillebeeckx, P., Sedyshev, P., Smith, A. G., Sosnin, N. V., Stamatopoulos, A., Tagliente, G., Tain, J. L., Tarifeño-Saldivia, A., Tassan-Got, L., Valenta, S., Vannini, G., Variale, V., Vaz, P., Ventura, A., Vlachoudis, V., Vlastou, R., Wallner, A., Warren, S., Weiss, C., Woods, P. J., Wright, T., and Žugec, P.
Subjects: Physics - Instrumentation and Detectors
Abstract: Following the completion of the second neutron beam line and the related experimental area (EAR2) at the n_TOF spallation neutron source at CERN, several experiments were planned and performed. The high instantaneous neutron flux available in EAR2 allows to investigate neutron indiced reactions with charged particles in the exit channel even employing targets made out of small amounts of short-lived radioactive isotopes. After the successful measurement of the 7Be(n,{\alpha}){\alpha} cross section, the 7Be(n,p)7Li reaction was studied in order to provide still missing cross section data of relevance for Big Bang Nucleosynthesis (BBN), in an attempt to find a solution to the cosmological Lithium abundance problem. This paper describes the experimental setup employed in such a measurement and its characterization.
Published: 2017
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12. Six winters of photometry from Dome C, Antarctica: challenges, improvements, and results from the ASTEP experiment

Author: Crouzet, N., Mékarnia, D., Guillot, T., Abe, L., Agabi, A., Rivet, J. -P., Gonçalves, I., Schmider, F. -X., Daban, J. -B., Fanteï-Caujolle, Y., Gouvret, C., Bayliss, D. D. R., Zhou, G., Aristidi, E., Fruth, T., Erikson, A., Rauer, H., Szulágyi, J., Bondoux, E., Challita, Z., Pouzenc, C., Fressin, F., Valbousquet, F., Barbieri, M., Blazit, A., Bonhomme, S., Bouchy, F., Gerakis, J., and Bouchez, G.
Subjects: Astrophysics - Instrumentation and Methods for Astrophysics
Abstract: ASTEP (Antarctica Search for Transiting ExoPlanets) is a pilot project that aims at searching and characterizing transiting exoplanets from Dome C in Antarctica and to qualify this site for photometry in the visible. Two instruments were installed at Dome C and ran for six winters in total. The analysis of the collected data is nearly complete. We present the operation of the instruments, and the technical challenges, limitations, and possible solutions in light of the data quality. The instruments performed continuous observations during the winters. Human interventions are required mainly for regular inspection and ice dust removal. A defrosting system is efficient at preventing and removing ice on the mirrors. The PSF FWHM is 4.5 arcsec on average which is 2.5 times larger than the specification, and is highly variable; the causes are the poor ground-level seeing, the turbulent plumes generated by the heating system, and to a lower extent the imperfect optical alignment and focusing, and some astigmatism. We propose solutions for each of these aspects that would largely increase the PSF stability. The astrometric and guiding precisions are satisfactory and would deserve only minor improvements. Major issues are encountered with the camera shutter which did not close properly after two winters; we minimized this issue by heating the shutter and by developing specific image calibration algorithms. Finally, we summarize the site testing and science results obtained with ASTEP. Overall, the ASTEP experiment will serve as a basis to design and operate future optical and near-infrared telescopes in Antarctica., Comment: 10 pages, 6 figures, SPIE conference proceedings, Ground-based and Airborne Instrumentation for Astronomy VI, 2016
Published: 2016
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13. Neutron capture cross section measurement of 238U at the n TOF CERN facility with C6D6 scintillation detectors in the energy region from 1 eV to 700 keV

Author: Collaboration, n_TOF, Mingrone, F., Massimi, C., Vannini, G., Colonna, N., Gunsing, F., Žugec, P., Altstadt, S., Andrzejewski, J., Audouin, L., Barbagallo, M., Bécares, V., Bečvář, F., Belloni, F., Berthoumieux, E., Billowes, J., Bosnar, D., Brugger, M., Calviani, M., Calviño, F., Cano-Ott, D., Carrapiço, C., Cerutti, F., Chiaveri, E., Chin, M., Cortés, G., Cortés-Giraldo, M. A., Diakaki, M., Domingo-Pardo, C., Duran, I., Dressler, R., Eleftheriadis, C., Ferrari, A., Fraval, K., Ganesan, S., García, A. R., Giubrone, G., Gonçalves, I. F., González-Romero, E., Griesmayer, E., Guerrero, C., Hernández-Prieto, A., Jenkins, D. G., Jericha, E., Kadi, Y., Käppeler, F., Karadimos, D., Kivel, N., Koehler, P., Kokkoris, M., Krtička, 1 M., Kroll, J., Lampoudis, C., Langer, C., Leal-Cidoncha, E., Lederer, C., Leeb, H., Leong, L. S., Meo, S. Lo, Losito, R., Mallick, A., Manousos, A., Marganiec, J., Martínez, T., Mastinu, P. F., Mastromarco, M., Mendoza, E., Mengoni, A., Milazzo, P. M., Mirea, M., Mondalaers, W., Paradela, C., Pavlik, A., Perkowski, J., Plompen, A., Praena, J., Quesada, J. M., Rauscher, T., Reifarth, R., Riego, A., Robles, M. S., Rubbia, C., Sabaté-Gilarte, M., Sarmento, R., Saxena, A., Schillebeeckx, P., Schmidt, S., Schumann, D., Tagliente, G., Tain, J. L., Tarrío, D., Tassan-Got, L., Tsinganis, A., Valenta, S., Variale, V., Vaz, P., Ventura, A., Vermeulen, M. J., Vlachoudis, V., Vlastou, R., Wallner, A., Ware, T., Weigand, M., Weiß, C., and Wright, T.
Subjects: Nuclear Experiment
Abstract: The aim of this work is to provide a precise and accurate measurement of the 238U(n,g) reaction cross section in the energy region from 1 eV to 700 keV. This reaction is of fundamental importance for the design calculations of nuclear reactors, governing the behaviour of the reactor core. In particular, fast reactors, which are experiencing a growing interest for their ability to burn radioactive waste, operate in the high energy region of the neutron spectrum. In this energy region most recent evaluations disagree due to inconsistencies in the existing measurements of up to 15%. In addition, the assessment of nuclear data uncertainty performed for innovative reactor systems shows that the uncertainty in the radiative capture cross-section of 238U should be further reduced to 1-3% in the energy region from 20 eV to 25 keV. To this purpose, addressed by the Nuclear Energy Agency as a priority nuclear data need, complementary experiments, one at the GELINA and two at the n_TOF facility, were proposed and carried out within the 7th Framework Project ANDES of the European Commission. The results of one of these 238U(n,g) measurements performed at the n_TOF CERN facility are presented in this work. The gamma-ray cascade following the radiative neutron capture has been detected exploiting a setup of two C6D6 liquid scintillators. Resonance parameters obtained from this work are on average in excellent agreement with the ones reported in evaluated libraries. In the unresolved resonance region, this work yields a cross section in agreement with evaluated libraries up to 80 keV, while for higher energies our results are significantly higher., Comment: 15 pages, 10 captioned figures
Published: 2016
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14. The extracellular matrix proteoglycan serglycin is associated with human atherosclerotic plaque inflammation

Author: Gialeli, C, primary, Fountas, P, additional, Shami, A, additional, Sun, J, additional, Bocci, M, additional, Nitulescu, M, additional, Persson, A, additional, Bengtsson, E, additional, Knutsen, E, additional, Pietras, K, additional, Theocharis, A, additional, Edsfeldt, A, additional, and Goncalves, I, additional
Published: 2024
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15. Circulating LIGHT/TNFSF14 levels are negatively associated with cardiovascular mortality, while intra-plaque levels are associated with symptomatic cerebrovascular disease

Author: Shami, A, primary, Edsfeldt, A, additional, Nilsson, J, additional, and Goncalves, I, additional
Published: 2024
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16. Asporin expression is associated with human atherosclerotic plaque integrity

Author: Fountas, P, primary, Gialeli, C, additional, Sun, J, additional, Nitulescu, M, additional, Persson, A, additional, Bengtsson, E, additional, Edsfeldt, A, additional, and Goncalves, I, additional
Published: 2024
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17. Analogue Fluids for Cell Deformability Studies in Microfluidic Devices

Author: Moita, A. S., Caldeira, C., Gonçalves, I., Lima, R., Vega, E. J., Moreira, A. L. N., Filipe, Joaquim, Editorial Board Member, Ghosh, Ashish, Editorial Board Member, Kotenko, Igor, Editorial Board Member, Prates, Raquel Oliveira, Editorial Board Member, Zhou, Lizhu, Editorial Board Member, Roque, Ana, editor, Tomczyk, Arkadiusz, editor, De Maria, Elisabetta, editor, Putze, Felix, editor, Moucek, Roman, editor, Fred, Ana, editor, and Gamboa, Hugo, editor
Published: 2020
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18. Integral measurement of the $^{12}$C(n,p)$^{12}$B reaction up to 10 GeV

Author: Žugec, P., Colonna, N., Bosnar, D., Ventura, A., Mengoni, A., Altstadt, S., Andrzejewski, J., Audouin, L., Barbagallo, M., Bécares, V., Bečvář, F., Belloni, F., Berthoumieux, E., Billowes, J., Boccone, V., Brugger, M., Calviani, M., Calviño, F., Cano-Ott, D., Carrapiço, C., Cerutti, F., Chiaveri, E., Chin, M., Cortés, G., Cortés-Giraldo, M. A., Cosentino, L., Diakaki, M., Domingo-Pardo, C., Dressler, R., Duran, I., Eleftheriadis, C., Ferrari, A., Finocchiaro, P., Fraval, K., Ganesan, S., García, A. R., Giubrone, G., Gómez-Hornillos, M. B., Gonçalves, I. F., González-Romero, E., Griesmayer, E., Guerrero, C., Gunsing, F., Gurusamy, P., Heinitz, S., Jenkins, D. G., Jericha, E., Käppeler, F., Karadimos, D., Kivel, N., Kokkoris, M., Krtička, M., Kroll, J., Langer, C., Lederer, C., Leeb, H., Leong, L. S., Meo, S. Lo, Losito, R., Manousos, A., Marganiec, J., Martínez, T., Massimi, C., Mastinu, P., Mastromarco, M., Mendoza, E., Milazzo, P. M., Mingrone, F., Mirea, M., Mondalaers, W., Musumarra, A., Paradela, C., Pavlik, A., Perkowski, J., Plompen, A., Praena, J., Quesada, J., Rauscher, T., Reifarth, R., Riego, A., Roman, F., Rubbia, C., Sarmento, R., Saxena, A., Schillebeeckx, P., Schmidt, S., Schumann, D., Tagliente, G., Tain, J. L., Tarrío, D., Tassan-Got, L., Tsinganis, A., Valenta, S., Vannini, G., Variale, V., Vaz, P., Versaci, R., Vermeulen, M. J., Vlachoudis, V., Vlastou, R., Wallner, A., Ware, T., Weigand, M., Weiß, C., and Wright, T.
Subjects: Nuclear Experiment
Abstract: The integral measurement of the $^{12}$C(n,p)$^{12}$B reaction was performed at the neutron time of flight facility n_TOF at CERN. The total number of $^{12}$B nuclei produced per neutron pulse of the n_TOF beam was determined using the activation technique in combination with a time of flight technique. The cross section is integrated over the n_TOF neutron energy spectrum from reaction threshold at 13.6 MeV to 10 GeV. Having been measured up to 1 GeV on basis of the $^{235}$U(n,f) reaction, the neutron energy spectrum above 200 MeV has been reevaluated due to the recent extension of the cross section reference for this particular reaction, which is otherwise considered a standard up to 200 MeV. The results from the dedicated GEANT4 simulations have been used to evaluate the neutron flux from 1 GeV up to 10 GeV. The experimental results related to the $^{12}$C(n,p)$^{12}$B reaction are compared with the evaluated cross sections from major libraries and with the predictions of different GEANT4 models, which mostly underestimate the $^{12}$B production. On the contrary, a good reproduction of the integral cross section derived from measurements is obtained with TALYS-1.6 calculations, with optimized parameters., Comment: 14 pages, 11 figures, 3 tables
Published: 2016
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19. Experimental setup and procedure for the measurement of the 7Be(n,{\alpha}){\alpha} reaction at n_TOF

Author: Cosentino, L., Musumarra, A., Barbagallo, M., Pappalardo, A., Colonna, N., Damone, L., Piscopo, M., Finocchiaro, P., Maugeri, E., Heinitz, S., Schumann, D., Dressler, R., Kivel, N., Aberle, O., Andrzejewski, J., Audouin, L., Ayranov, M., Bacak, M., Barros, S., Balibrea-Correa, J., Beecares, V., Becvar, F., Beinrucker, C., Berthoumieux, E., Billowes, J., Bosnar, D., Brugger, M., Caamano, M., Calviani, M., Calvino, F., Cano-Ott, D., Cardella, R., Casanovas, A., Castelluccio, D. M., Cerutti, F., Chen, Y. H., Chiaveri, E., Cortes, G., Cortes-Giraldo, M. A., Diakaki, M., Domingo-Pardo, C., Dupont, E., Duran, I., Fernandez-Dominguez, B., Ferrari, A., Ferreira, P., Furman, W., Ganesan, S., Garcia-Rios, A., Gawlik, A., Gheorghe, I., Glodariu, T., Goebel, K., Goncalves, I. F., Gonzalez-Romero, E., Griesmayer, E., Guerrero, C., Gunsing, F., Harada, H., Heftrich, T., Heyse, J., Jenkins, D. G., Jericha, E., Kaeppeler, F., Katabuchi, T., Kavrigin, P., Kimura, A., Kokkoris, M., Krticka, M., Leal-Chidonca, E., Lerendegui, J., Lederer, C., Leeb, H., Meo, S. Lo, Lonsdale, S., Losito, R., Macina, D., Marganiec, J., Martinez, T., Massimi, C., Mastinu, P., Mastromarco, M., Matteucci, F., Mazzone, A., Mendoza, E., Mengoni, A., Milazzo, P. M., Mingrone, F., Mirea, M., Montesano, S., Nolte, R., Oprea, A., Patronis, N., Pavlik, A., Perkowski, J., Praena, J., Quesada, J., Rajeev, K., Rauscher, T., Reifarth, R., Riego-Perez, A., Rout, P., Rubbia, C., Ryan, J., Sabate-Gilarte, M., Saxena, A., Schillebeeckx, P., Schmidt, S., Sedyshev, P., Stamatopoulos, A., Tagliente, G., Tain, J. L., Tarifeno-Saldivia, A., Tassan-Got, L., Tsinganis, A., Valenta, S., Vannini, G., Variale, V., Vaz, P., Ventura, A., Vlachoudis, V., Vlastou, R., Vollaire, J., Wallner, A., Warren, S., Weigand, M., Weiß, C., Wolf, C., Woods, P. J., Wright, T., Zugec, P., and collaboration, n_TOF
Subjects: Physics - Instrumentation and Detectors, High Energy Physics - Experiment, Nuclear Experiment
Abstract: The newly built second experimental area EAR2 of the n_TOF spallation neutron source at CERN allows to perform (n, charged particles) experiments on short-lived highly radioactive targets. This paper describes a detection apparatus and the experimental procedure for the determination of the cross-section of the 7Be(n,{\alpha}) reaction, which represents one of the focal points toward the solution of the cosmological Lithium abundance problem, and whose only measurement, at thermal energy, dates back to 1963. The apparently unsurmountable experimental difficulties stemming from the huge 7Be {\gamma}-activity, along with the lack of a suitable neutron beam facility, had so far prevented further measurements. The detection system is subject to considerable radiation damage, but is capable of disentangling the rare reaction signals from the very high background. This newly developed setup could likely be useful also to study other challenging reactions requiring the detectors to be installed directly in the neutron beam., Comment: submitted to Nuclear Instruments and Methods in Physics Research A
Published: 2016
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20. Thrombosis in patients with immune thrombocytopenia: incidence, risk, and clinical outcomes

Author: Goncalves, I, Lewis, C, Grainger, B, Dring, R, Lee, N, Pasricha, S-R, Szer, J, Mason, K, Goncalves, I, Lewis, C, Grainger, B, Dring, R, Lee, N, Pasricha, S-R, Szer, J, and Mason, K
Abstract: BACKGROUND: There is evidence that patients with immune thrombocytopenia (ITP) are at increased risk of thrombosis. However, the association of clinical- and treatment-related factors with thrombosis remains controversial. OBJECTIVES: To evaluate the incidence and impact of risk factors for arterial and venous thromboembolism (VTE) in patients with ITP and characterize the clinical features and management of patients. METHODS: We performed a retrospective cohort study (January 1, 2011, to October 30, 2022) of adult patients diagnosed with ITP from an Australian tertiary hospital. The incidence rates of thrombosis were calculated in terms of person-years of follow-up. Multiadjusted Cox regression was used to estimate associations. RESULTS: A total of 220 patients with 1365 person-years of follow-up since ITP diagnosis revealed 26 (11.8%) patients with a total of 37 thrombosis events, 29 (78%) VTE and 8 (22%) arterial thromboembolism (ATE). The incidence rate of thrombosis was 2.71 (95% CI, 1.97-3.72) (0.66 [95% CI, 0.33-1.26] for arterial thromboembolism and 2.05 [95% CI, 1.42-2.95] for VTE) per 100 person-years. Mean age and median time to first thrombosis diagnosis was 56 and 2.13 years, respectively. Age, secondary ITP, lines of therapy, thrombosis risk factors, and thrombopoietin receptor agonist therapy were independently associated with thrombosis. Almost all patients (25 of 26, [96%]) had good ITP disease control prior to thrombosis diagnosis, and antithrombotic therapy was deliverable and well tolerated. CONCLUSION: Diagnosis of thrombosis in patients with ITP, while infrequent, is of clinical significance. We identified from a heterogeneous real-world cohort that older patients with multiply-treated secondary ITP receiving thrombopoietin receptor agonists are at the highest risk.
Published: 2024

21. Shedding of membrane complement inhibitors CD59 and CD46 into the circulation is associated with poor prognosis in acute coronary syndrome patients: a cohort study.

Author: Zhong B, King B, Waziri H, Yndigegn T, Engelbertsen D, Björkbacka H, Nilsson J, Goncalves I, Blom AM, and Schiopu A
Subjects: Humans, Male, Female, Prognosis, Cohort Studies, Aged, Middle Aged, Risk Factors, Acute Coronary Syndrome blood, CD59 Antigens blood, Membrane Cofactor Protein blood
Abstract: Introduction: The role of the complement inhibitory proteins CD46 and CD59 in the immune response to an acute coronary syndrome (ACS) is unknown. We investigated the relationships between the shedding of CD46 and CD59 into the circulation, reflected by plasma levels of soluble CD46 and CD59, and the risk for post-ACS complications., Methods: We measured plasma sCD46 and sCD59 in a cohort of 546 ACS patients within 24 h after hospital admission, and after 6-weeks in a subgroup of 114 patients. Study outcomes were incident heart failure (HF), major adverse cardiovascular events (MACE) and mortality during a median follow-up period of up to 3.3 years. Echocardiography at 1-year was performed in the follow-up subgroup., Results: Elevated sCD46 and sCD59 were correlated with increased levels of inflammatory mediators and metalloproteinases in plasma, and were associated with increased risk for MACE in Cox proportional hazard models adjusted for cardiovascular risk factors and revascularization [HR 95% CI 1.24 (1.02-1.52), p = 0.034 for sCD46 and 1.18 (1.00-1.38), p = 0.049 for sCD59]. Elevated sCD59 was also associated with higher incidence of HF [HR 95% CI 1.41 (1.15-1.74), p = 0.001], and with lower left ventricular ejection fraction at 1-year post-ACS (Spearman r = - 0.234, p = 0.020). We found no associations between plasma levels of the proteins at 6 weeks and outcomes., Conclusions: Shedding of the complement regulators CD46 and CD59 in plasma in the acute phase of ACS is associated with a negative prognosis. Plasma sCD46 and sCD59 could reflect the degree of local immune activation and serve as prognostic biomarkers in ACS patients., Competing Interests: Declarations Ethics approval and consent to participate All patients signed an informed consent form before inclusion in the study. The study was approved by the Regional Ethics Committee for human studies in Lund, Sweden (reference number 211/2007). Consent for publication Not applicable. Competing interests The authors declare that they have no competing interests., (© 2024. The Author(s).)
Published: 2024
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22. Transcriptomic changes in the PacC transcription factor deletion mutant of the plant pathogenic fungus Botrytis cinerea under acidic and neutral conditions.

Author: Rascle C, Malbert B, Goncalves I, Choquer M, Bruel C, and Poussereau N
Subjects: Hydrogen-Ion Concentration, Transcriptome genetics, Gene Expression Regulation, Fungal, Plant Diseases microbiology, Gene Deletion, Botrytis genetics, Botrytis pathogenicity, Transcription Factors genetics, Transcription Factors metabolism, Fungal Proteins genetics, Fungal Proteins metabolism
Abstract: Objectives: Botrytis cinerea, the causal agent of gray mold, is a necrotrophic fungus that can infect a wide variety of plant species and plant tissues. During infection, this pathogen modulates the pH of its environment by secreting organic acids or ammonia. Deletion of the gene encoding the pH-responsive transcription factor PacC revealed the importance of this regulator in different steps of the infection process and particularly in the secretion of organics acids, reactive oxygen species and plant cell wall degrading enzymes. This study aimed to identify the genes controlled by this fungus-specific transcription factor when the fungus is placed under acidic or neutral conditions., Data Description: Botrytis cinerea B05.10 and the knock-out BcpacC mutant strains were grown on solid non-buffered medium for 3 days on the surface of cellophane membranes before transfer for 4 h onto the surface of liquid medium buffered at pH 5.0 or 7.0 followed by mycelium collection. After RNA sequencing, differentially expressed genes according to strains or pH conditions were listed. These data will be useful in understanding the adaptation process of B cinerea during plant infection., (© 2024. The Author(s).)
Published: 2024
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23. Reservoir-excess pressure parameters are independently associated with NT-proBNP in older adults.

Author: Aizawa K, Hughes AD, Casanova F, Gooding KM, Gates PE, Mawson DM, Williams J, Goncalves I, Nilsson J, Khan F, Colhoun HM, Palombo C, Parker KH, and Shore AC
Subjects: Humans, Male, Female, Aged, Cross-Sectional Studies, Aged, 80 and over, Blood Pressure physiology, Manometry, Natriuretic Peptide, Brain blood, Peptide Fragments blood, Biomarkers blood
Abstract: Aims: Parameters derived from reservoir-excess pressure analysis have been demonstrated to predict cardiovascular events. Thus, altered reservoir-excess pressure parameters could have a detrimental effect on highly-perfused organs like the heart. We aimed to cross-sectionally determine whether reservoir-excess pressure parameters were associated with N-terminal pro-brain-type natriuretic peptide (NT-proBNP) in older adults., Methods: We studied 868 older adults with diverse cardiovascular risk. Reservoir-excess pressure parameters were obtained through radial artery tonometry including reservoir pressure integral, peak reservoir pressure, excess pressure integral (INTXSP), systolic rate constant (SRC) and diastolic rate constant (DRC). Plasma levels of NT-proBNP, as a biomarker of cardiac overload, were analysed by the Proximity Extension Assay technology., Results: Multivariable linear regression analyses revealed that all reservoir-excess pressure parameters studied were associated with NT-proBNP after adjusting for age and sex. After further adjustments for conventional cardiovascular risk factors, INTXSP [β = 0.191 (95% confidence interval, CI: 0.099, 0.283), P < 0.001], SRC [β = -0.080 (95% CI: -0.141, -0.019), P = 0.010] and DRC [β = 0.138 (95% CI: 0.073, 0.202), P < 0.001] remained associated with NT-proBNP. Sensitivity analysis found that there were occasions where the association between SRC and NT-proBNP was attenuated, but both INTXSP and DRC remained consistently associated with NT-proBNP., Conclusions: The observed associations between reservoir-excess pressure parameters and NT-proBNP suggest that altered reservoir-excess pressure parameters may reflect an increased load inflicted on the left ventricular cardiomyocytes and could have a potential to be utilized in the clinical setting for cardiovascular risk stratification., (© 2024 The Author(s). ESC Heart Failure published by John Wiley & Sons Ltd on behalf of European Society of Cardiology.)
Published: 2024
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24. Assessing the effect of below-benchmark vitrified/warmed donor-oocyte survival rates in subsequent laboratory and clinical outcomes.

Author: Gallardo M, Goncalves I, Redondo J, Soares AP, Garrido N, and Metello JL
Abstract: Objective: To assess the impact of below-benchmark (95%-100%) donor-oocyte survival rates on vitrification/warming in the laboratory and clinical outcomes of recipient cycles., Design: Retrospective cohort study., Setting: A network of European private in vitro fertilization units., Patient(s): We analyzed 12,690 vitrified-warmed donor-oocyte recipient cycles performed from 2018-2022., Intervention(s): All cycles analyzed used exclusively vitrified/warmed donor oocytes. The cycles were grouped according to the survival rate experienced: benchmark 95%-100%; competence 85%-95%; below competence 70%-85%; poor 50%-70%; and very poor <50%., Main Outcome Measure(s): The primary endpoint of the study was the total usable blastocyst rate per 2 pronuclear (2PN) zygote. Secondary endpoints were the fertilization rate, the live birth rate after the first single blastocyst transfer, and the cumulative live birth rate., Result(s): The mean number of warmed oocytes per intracytoplasmic sperm injection (ICSI) cycle was 11.4 ± 3.2, with a mean survival rate of 89.1%. More oocytes per cycle were consumed in the lower survival groups, yet the total number of oocytes available for ICSI was smaller in the below-competence, poor, and very poor survival groups. The total usable blastocyst rate was lower in the lower survival groups (benchmark: 48.9%; competence: 47.0%, below competence: 46.0%; poor: 43.6%; and very poor: 43.6%), as well as the fertilization rates (benchmark: 76.8%; competence: 76.6%, below competence: 75.6%; poor: 74.7%; and very poor:75.5%). The adjusted relative risk (aRR) of live birth rate of the first embryo transferred was equal to the benchmark survival group in all the lower survival groups (benchmark: 40.9%; competence: aRR = 0.986, 95% confidence interval [CI]: 0.931-1.045; below-competence: aRR = 0.992, 95% CI: 0.929-1.059; poor: aRR = 1.103, 95% CI: 1.009-1.207; and very poor: aRR = 1.169, 95% CI: 0.963-1.419). The cumulative live birth rate decreased in lower survival groups compared with benchmark survival (benchmark: 79.2%; competence: aRR = 0.988, 95% CI: 0.961-1.015; below competence: aRR = 0.911, 95% CI: 0.880-0.944; poor: aRR = 0.802, 95% CI: 0.757-0.851; and very poor: aRR = 0.793, 95% CI: 0.693-0.907). The lower cumulative rates maintained in a subanalysis with equal metaphase-II available for ICSI (benchmark: 69.5%; competence: aRR = 0.909, 95% CI: 0.827-1.000; below competence: aRR = 0.942, 95% CI: 0.848-1.046; poor: aRR = 0.833, 95% CI: 0.7386-0.941; and very poor: aRR = 0.873, 95% CI: 0.695-1.097) CONCLUSIONS: Lower donor-oocyte cryo-survival rates have a moderate negative impact on the blastocyst utilization rate per 2PN zygote, fertilization rate, and the cumulative live birth rates of a donation cycle, even after adjusting for equal metaphase-II oocytes available for ICSI. Nonetheless, the surviving oocytes of a cohort seem to maintain a high competence level, with very similar laboratory outcomes, irrespective of the cohort's survival rates, as well as equal implantation potential of the resulting blastocysts., Competing Interests: Declaration of Interests M.G. reports honoraria from Merck GmBH outside the submitted work. I.G. has nothing to disclose. J.R. has nothing to disclose. A.P.S. has nothing to disclose. N.G. has nothing to disclose. J.L.M. has nothing to disclose., (Copyright © 2024 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.)
Published: 2024
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25. Elevated carbohydrate antigen 125 (CA125) is associated with incident heart failure and mortality in acute coronary syndrome.

Author: Yndigegn T, Gu T, Grufman H, Erlinge D, Mokhtari A, Ekelund U, Magnusson M, Gustafsson E, Nilsson J, Goncalves I, and Schiopu A
Abstract: Aims: Carbohydrate antigen 125 (CA125), a mucin produced by serosal cells in response to mechanical and inflammatory stimuli, has emerged as an important biomarker to guide risk stratification in heart failure (HF). The prognostic value of CA125 in acute coronary syndrome (ACS) patients is less explored., Methods: In a cohort of 524 ACS patients (73% males, mean age 67 ± 12 years), we assessed the associations between CA125 and the risk for HF and death during a median follow-up period of 27.3 months for incident HF and 39.5 months for mortality. Plasma CA125 was measured within 24 h after admission in the entire cohort and after 6 weeks in a subgroup of 115 elderly patients (>75 years of age). We also assessed the relationships between baseline CA125 and echocardiographic parameters of cardiac structure and function at 1 year post-ACS in this subgroup., Results: Baseline CA125 was associated with incident HF in the entire cohort in a Cox proportional hazards model adjusted for age, sex, cardiovascular (CV) risk factors (diabetes, smoking, hypertension, previous HF, previous ACS and previous stroke), renal function and revascularization {hazard ratio [HR] 1.46 [95% confidence interval (CI) 1.10-1.93] per 1-standard deviation [SD] CA125 increase; P = 0.009}. In the detailed follow-up subgroup, elevated baseline CA125 predicted subsequent deterioration of left ventricular (LV) ejection fraction (LVEF), defined as a >5% absolute LVEF decrease in patients with LVEF ≥ 50% at discharge [odds ratio (OR) 3.31 (95% CI 1.15-9.54) per 1-SD baseline CA125 increase; P = 0.027]. We also found significant correlations between high baseline CA125 and larger LV volumes (LV end-diastolic volume index, Spearman's r = 0.329, P < 0.001; LV end-systolic volume index, r = 0.391, P < 0.001) and left atrial volume index (r = 0.320, P < 0.001) at 1 year post-ACS, indicative of adverse cardiac remodelling. Elevated baseline and follow-up CA125 were associated with increased mortality, independently of age and sex [HR 1.37 (95% CI 1.09-1.71), P = 0.006, per 1-SD baseline CA125; HR 1.98 (95% CI 1.06-3.67), P = 0.031, per increasing 6 week CA125 tertile]. The relationship between 6 week CA125 and incident mortality remained significant in the fully adjusted model [HR 2.23 (95% CI 1.15-4.35) per increasing CA125 tertile; P = 0.018]., Conclusions: We report independent associations between elevated CA125, LV dysfunction, cardiac remodelling, incident HF and mortality post-ACS. Our results warrant further evaluation of CA125 as a potential biomarker for risk stratification and management of ACS patients, both at the time of the acute coronary event and during follow-up., (© 2024 The Author(s). ESC Heart Failure published by John Wiley & Sons Ltd on behalf of European Society of Cardiology.)
Published: 2024
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26. Measurement and analysis of the Am-243 neutron capture cross section at the n_TOF facility at CERN

Author: Collaboration, n_TOF, Mendoza, E., Cano-Ott, D., Guerrero, C., Berthoumieux, E., Abbondanno, U., Aerts, G., Alvarez-Velarde, F., Andriamonje, S., Andrzejewski, J., Assimakopoulos, P., Audouin, L., Badurek, G., Balibrea, J., Baumann, P., Becvar, F., Belloni, F., Calvino, F., Calviani, M., Capote, R., Carrapico, C., de Albornoz, A. Carrillo, Cennini, P., Chepel, V., Chiaveri, E., Colonna, N., Cortes, G., Couture, A., Cox, J., Dahlfors, M., David, S., Dillmann, I., Dolfini, R., Domingo-Pardo, C., Dridi, W., Duran, I., Eleftheriadis, C., Ferrant, L., Ferrari, A., Ferreira-Marques, R., Fitzpatrick, L., Frais-Koelbl, H., Fujii, K., Furman, W., Goncalves, I., Gonzalez-Romero, E., Goverdovski, A., Gramegna, F., Griesmayer, E., Gunsing, F., Haas, B., Haight, R., Heil, M., Herrera-Martinez, A., Igashira, M., Isaev, S., Jericha, E., Kappeler, F., Kadi, Y., Karadimos, D., Karamanis, D., Ketlerov, V., Kerveno, M., Koehler, P., Konovalov, V., Kossionides, E., Krticka, M., Lampoudis, C., Leeb, H., Lindote, A., Lopes, I., Lossito, R., Lozano, M., Lukic, S., Marganiec, J., Marques, L., Marrone, S., Martinez, T., Massimi, C., Mastinu, P., Mengoni, A., Milazzo, P. M., Moreau, C., Mosconi, M., Neves, F., Oberhummer, H., Brien, S. O, Oshima, M., Pancin, J., Papachristodoulou, C., Papadopoulos, C., Paradela, C., Patronis, N., Pavlik, A., Pavlopoulos, P., Perrot, L., Pigni, M. T., Plag, R., Plompen, A., Plukis, A., Poch, A., Praena, J., Pretel, C., Quesada, J., Rauscher, T., Reifarth, R., Rosetti, M., Rubbia, C., Rudolf, G., Rullhusen, P., Salgado, J., Santos, C., Sarchiapone, L., Savvidis, I., Stephan, C., Tagliente, G., Tain, J. L., Tassan-Got, L., Tavora, L., Terlizzi, R., Vannini, G., Vaz, P., Ventura, A., Villamarin, D., Vicente, M. C., Vlachoudis, V., Vlastou, R., Voss, F., Walter, S., Wendler, H., Wiescher, M., and Wisshak, K.
Subjects: Nuclear Experiment
Abstract: Background:The design of new nuclear reactors and transmutation devices requires to reduce the present neutron cross section uncertainties of minor actinides. Purpose: Reduce the $^{243}$Am(n,$\gamma$) cross section uncertainty. Method: The $^{243}$Am(n,$\gamma$) cross section has been measured at the n_TOF facility at CERN with a BaF$_{2}$ Total Absorption Calorimeter, in the energy range between 0.7 eV and 2.5 keV. Results: The $^{243}$Am(n,$\gamma$) cross section has been successfully measured in the mentioned energy range. The resolved resonance region has been extended from 250 eV up to 400 eV. In the unresolved resonance region our results are compatible with one of the two incompatible capture data sets available below 2.5 keV. The data available in EXFOR and in the literature has been used to perform a simple analysis above 2.5 keV. Conclusions: The results of this measurement contribute to reduce the $^{243}$Am(n,$\gamma$) cross section uncertainty and suggest that this cross section is underestimated up to 25% in the neutron energy range between 50 eV and a few keV in the present evaluated data libraries.
Published: 2014
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27. Safety Stream Mapping—A New Tool Applied to the Textile Company as a Case Study

Author: Gonçalves, I., Sá, J. C., Santos, G., Gonçalves, M., Kacprzyk, Janusz, Series Editor, Arezes, Pedro M., editor, Baptista, João S., editor, Barroso, Mónica P., editor, Carneiro, Paula, editor, Cordeiro, Patrício, editor, Costa, Nélson, editor, Melo, Rui B., editor, Miguel, A. Sérgio, editor, and Perestrelo, Gonçalo, editor
Published: 2019
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28. TOF Facility at CERN

Author: The n_TOF Collaboration, Damone, L. A., Barbagallo, M., Mastromarco, M., Mengoni, A., Colonna, N., Cosentino, L., Maugeri, E. A., Heinitz, S., Schumann, D., Dressler, R., Käppeler, F., Finocchiaro, P., Andrzejewski, J., Perkowski, J., Gawlik, A., Aberle, O., Altstadt, S., Ayranov, M., Audouin, L., Bacak, M., Balibrea-Correa, J., Ballof, J., Bcares, V., Bečvař, F., Beinrucker, C., Bellia, G., Bernardes, A. P., Berthoumieux, E., Billowes, J., Borge, M. J. G., Bosnar, D., Brown, A., Brugger, M., Busso, Maurizio, Caamaño, M., Calviño, F., Calviani, M., Cano-Ott, D., Cardella, R., Casanovas, A., Castelluccio, D. M., Catherall, R., Cerutti, F., Chen, Y. H., Chiaveri, E., Corts, G., Cortès-Giraldo, M. A., Cristallo, Sergio, Diakaki, M., Dietz, M., Domingo-Pardo, C., Dorsival, A., Dupont, E., Durán, I., Fernàndez-Dominguez, B., Ferrari, A., Ferreira, P., Furman, W., Ganesan, S., Garca-Rios, A., Gilardoni, S., Glodariu, T., Göbel, Kathrin, Gonçalves, I. F., Gonzalez-Romero, E., Goodacre, T. D., Griesmayer, E., Guerrero, C., Gunsing, F., Harada, H., Heftrich, Tanja, Heyse, J., Jenkins, D. G., Jericha, E., Johnston, K., Kadi, Y., Kalamara, A., Katabuchi, T., Kavrigin, P., Kimura, A., Kivel, N., Kohester, U., Kokkoris, M., Krtička, M., Kurtulgil, Deniz, Leal-Cidoncha, E., Lederer-Woods, Claudia, Leeb, H., Lerendegui-Marco, J., Lo Meo, S., Lonsdale, S. J., Losito, R., Macina, D., Marganiec, J., Marsh, B., Martínez, T., Martins Correia, J. G., Masi, A., Massimi, C., Mastinu, P., Matteucci, F., Mazzone, A., Mendoza, E., Milazzo, P. M., Mingrone, Federica, Mirea, M., Musumarra, A., Negret, A., Nolte, R., Oprea, A., Patronis, N., Pavlik, A., Piersanti, Luciano, Piscopo, M., Plompen, A., Porras, I., Praena, J., Quesada, J. M., Radeck, D., Rajeev, K., Rauscher, Thomas, Reifarth, René, Riego-Perez, A., Rothe, S., Rout, P., Rubbia, C., Ryan, J., Sabaté-Gilarte, M., Saxena, A., Schell, J., Schillebeeckx, P., Schmidt, S., Sedyshev, P., Seiffert, C., Smith, A. G., Sosnin, N. V., Stamatopoulos, A., Stora, T., Tagliente, G., Tain, J. L., Tarifeño-Saldivia, A., Tassan-Got, L., Tsinganis, A., Valenta, S., Vannini, G., Variale, V., Vaz, P., Ventura, A., Vlachoudis, V., Vlastou, R., Wallner, A., Warren, S., Weigand, Mario, Weiß, C., Wolf, C., Woods, P. J., Wright, T., Žugec, P., Formicola, Alba, editor, Junker, Matthias, editor, Gialanella, Lucio, editor, and Imbriani, Gianluca, editor
Published: 2019
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29. Data for the s Process from n_TOF

Author: The n_TOF Collaboration, Massimi, C., Aberle, O., Alcayne, V., Andrzejewski, J., Audouin, L., Bécares, V., Babiano-Suarez, V., Bacak, M., Barbagallo, M., Benedikt, Th., Bennett, S., Berthoumieux, E., Billowes, J., Bosnar, D., Brown, A., Busso, Maurizio, Caamaño, M., Caballero-Ontanaya, L., Calviño, F., Calviani, M., Cano-Ott, D., Casanovas, A., Castelluccio, D. M., Cerutti, F., Chiaveri, E., Clai, G., Colonna, N., Cortés, G., Cortès-Giraldo, M. A., Cosentino, L., Cristallo, Sergio, Damone, L. A., Davies, P. J., Dietz, M., Domingo-Pardo, C., Dressler, R., Ducasse, Q., Dupont, E., Durán, I., Eleme, Z., Fernàndez-Dominguez, B., Ferrari, A., Finocchiaro, P., Furman, V., Göbel, Kathrin, Gawlik, A., Gilardoni, S., Gonçalves, I. F., González-Romero, E., Guerrero, C., Gunsing, F., Heinitz, S., Heyse, J., Jenkins, D. G., Junghans, Arnd R., Käppeler, F., Kadi, Y., Kimura, A., Knapova, I., Kokkoris, M., Kopatch, Y., Krtička, M., Kurtulgil, Deniz, Ladarescu, I., Lederer-Woods, Claudia, Lonsdale, S. J., Macina, D., Manna, A., Martínez, T., Masi, A., Mastinu, P., Mastromarco, M., Matteucci, F., Maugeri, E. A., Mazzone, A., Mendoza, E., Mengoni, A., Michalopoulou, V., Milazzo, P. M., Mingrone, Federica, Moreno-Soto, J., Musumarra, A., Negret, A., Ogállar, F., Oprea, A., Patronis, N., Pavlik, A., Perkowski, J., Piersanti, Luciano, Petrone, C., Pirovano, E., Porras, I., Praena, J., Quesada, J. M., Ramos-Doval, D., Rauscher, Thomas, Reifarth, René, Rochman, D., Sabaté-Gilarte, M., Saxena, A., Schillebeeckx, P., Schumann, D., Sekhar, A., Simone, S., Smith, A. G., Sosnin, N. V., Sprung, P., Stamatopoulos, A., Tagliente, G., Tain, J. L., Tarifeño-Saldivia, A., Tassan-Got, L., Tsinganis, A., Ulrich, J., Urlass, Sebastian, Valenta, S., Vannini, G., Variale, V., Vaz, P., Ventura, A., Vescovi, Diego, Vlachoudis, V., Vlastou, R., Wallner, A., Woods, P. J., Wright, T., Žugec, P., Formicola, Alba, editor, Junker, Matthias, editor, Gialanella, Lucio, editor, and Imbriani, Gianluca, editor
Published: 2019
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30. High accuracy determination of the $^{238}$U/$^{235}$U fission cross section ratio up to $\sim$1 GeV at n_TOF (CERN)

Author: Paradela, C., Calviani, M., Tarrío, D., Leal-Cidoncha, E., Leong, L. S., Tassan-Got, L., Naour, C. Le, Duran, I., Colonna, N., Audouin, L., Mastromarco, M., Meo, S. Lo, Ventura, A., Altstadt, S., Andrzejewski, J., Barbagallo, M., Bécares, V., Bečvář, F., Belloni, F., Berthoumieux, E., Billowes, J., Boccone, V., Bosnar, D., Brugger, M., Calviño, F., Cano-Ott, D., Carrapiço, C., Cerutti, F., Chiaveri, E., Chin, M., Cortés, G., Cortés-Giraldo, M. A., Cosentino, L., Diakaki, M., Domingo-Pardo, C., Dressler, R., Eleftheriadis, C., Ferrari, A., Finocchiaro, P., Fraval, K., Ganesan, S., García, A. R., Giubrone, G., Gómez-Hornillos, M. B., Gonçalves, I. F., González-Romero, E., Griesmayer, E., Guerrero, C., Gunsing, F., Gurusamy, P., Heinitz, S., Jenkins, D. G., Jericha, E., Käppeler, F., Karadimos, D., Kivel, N., Kokkoris, M., Krtička, M., Kroll, J., Langer, C., Lederer, C., Leeb, H., Losito, R., Manousos, A., Marganiec, J., Martínez, T., Massimi, C., Mastinu, P., Mendoza, E., Mengoni, A., Milazzo, P. M., Mingrone, F., Mirea, M., Mondalaers, W., Musumarra, A., Pavlik, A., Perkowski, J., Plompen, A., Praena, J., Quesada, J., Rauscher, T., Reifarth, R., Riego, A., Roman, F., Rubbia, C., Sarmento, R., Saxena, A., Schillebeeckx, P., Schmidt, S., Schumann, D., Tagliente, G., Tain, J. L., Tsinganis, A., Valenta, S., Vannini, G., Variale, V., Vaz, P., Versaci, R., Vermeulen, M. J., Vlachoudis, V., Vlastou, R., Wallner, A., Ware, T., Weigand, M., Weiß, C., Wright, T., and Žugec, P.
Subjects: Nuclear Experiment
Abstract: The $^{238}$U to $^{235}$U fission cross section ratio has been determined at n_TOF up to $\sim$1 GeV, with two different detection systems, in different geometrical configurations. A total of four datasets have been collected and compared. They are all consistent to each other within the relative systematic uncertainty of 3-4%. The data collected at n_TOF have been suitably combined to yield a unique fission cross section ratio as a function of the neutron energy. The result confirms current evaluations up to 200 MeV. A good agreement is also observed with theoretical calculations based on the INCL++/Gemini++ combination up to the highest measured energy. The n_TOF results may help solving a long-standing discrepancy between the two most important experimental dataset available so far above 20 MeV, while extending the neutron energy range for the first time up to $\sim$1 GeV.
Published: 2014
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31. Measurement of the $^{12}$C($n,p$)$^{12}$B cross section at n_TOF (CERN) by in-beam activation analysis

Author: Žugec, P., Colonna, N., Bosnar, D., Mengoni, A., Altstadt, S., Andrzejewski, J., Audouin, L., Barbagallo, M., Bécares, V., Bečvář, F., Belloni, F., Berthoumieux, E., Billowes, J., Boccone, V., Brugger, M., Calviani, M., Cano-Ott, F. Calviño D., Carrapiço, C., Cerutti, F., Chiaveri, E., Chin, M., Cortés, G., Cortés-Giraldo, M. A., Cosentino, L., Diakaki, M., Domingo-Pardo, C., Dressler, R., Duran, I., Eleftheriadis, C., Ferrari, A., Finocchiaro, P., Fraval, K., Ganesan, S., García, A. R., Giubrone, G., Gómez-Hornillos, M. B., Gonçalves, I. F., González-Romero, E., Griesmayer, E., Guerrero, C., Gunsing, F., Gurusamy, P., Heinitz, S., Jenkins, D. G., Jericha, E., Käppeler, F., Karadimos, D., Kivel, N., Kokkoris, M., Krtička, M., Kroll, J., Langer, C., Lederer, C., Leeb, H., Leong, L. S., LoMeo, S., Losito, R., Manousos, A., Marganiec, J., Martínez, T., Massimi, C., Mastinu, P., Mastromarco, M., Mendoza, E., Milazzo, P. M., Mingrone, F., Mirea, M., Mondalaers, W., Musumarra, A., Paradela, C., Pavlik, A., Perkowski, J., Plompen, A., Praena, J., Quesada, J., Rauscher, T., Reifarth, R., Riego, A., Roman, F., Rubbia, C., Sarmento, R., Saxena, A., Schillebeeckx, P., Schmidt, S., Schumann, D., Tagliente, G., Tain, J. L., Tarrío, D., Tassan-Got, L., Tsinganis, A., Valenta, S., Vannini, G., Variale, V., Vaz, P., Ventura, A., Versaci, R., Vermeulen, M. J., Vlachoudis, V., Vlastou, R., Wallner, A., Ware, T., Weigand, M., Weiß, C., and Wright, T.
Subjects: Nuclear Experiment
Abstract: The integral cross section of the $^{12}$C($n,p$)$^{12}$B reaction has been determined for the first time in the neutron energy range from threshold to several GeV at the n_TOF facility at CERN. The measurement relies on the activation technique, with the $\beta$-decay of $^{12}$B measured over a period of four half-lives within the same neutron bunch in which the reaction occurs. The results indicate that model predictions, used in a variety of applications, are mostly inadequate. The value of the integral cross section reported here can be used as a benchmark for verifying or tuning model calculations., Comment: 6 pages, 4 figures
Published: 2014
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32. GEANT4 simulation of the neutron background of the C$_6$D$_6$ set-up for capture studies at n_TOF

Author: collaboration, n_TOF, Žugec, P., Colonna, N., Bosnar, D., Altstadt, S., Andrzejewski, J., Audouin, L., Barbagallo, M., Bécares, V., Bečvář, F., Belloni, F., Berthoumieux, E., Billowes, J., Boccone, V., Brugger, M., Calviani, M., Calviño, F., Cano-Ott, D., Carrapiço, C., Cerutti, F., Chiaveri, E., Chin, M., Cortés, G., Cortés-Giraldo, M. A., Diakaki, M., Domingo-Pardo, C., Dressler, R., Duran, I., Dzysiuk, N., Eleftheriadis, C., Ferrari, A., Fraval, K., Ganesan, S., García, A. R., Giubrone, G., Gómez-Hornillos, M. B., Gonçalves, I. F., González-Romero, E., Griesmayer, E., Guerrero, C., Gunsing, F., Gurusamy, P., Heinitz, S., Jenkins, D. G., Jericha, E., Kadi, Y., Käppeler, F., Karadimos, D., Kivel, N., Koehler, P., Kokkoris, M., Krtička, M., Kroll, J., Langer, C., Lederer, C., Leeb, H., Leong, L. S., Meo, S. Lo, Losito, R., Manousos, A., Marganiec, J., Martìnez, T., Massimi, C., Mastinu, P. F., Mastromarco, M., Meaze, M., Mendoza, E., Mengoni, A., Milazzo, P. M., Mingrone, F., Mirea, M., Mondalaers, W., Paradela, C., Pavlik, A., Perkowski, J., Plompen, A., Praena, J., Quesada, J. M., Rauscher, T., Reifarth, R., Riego, A., Roman, F., Rubbia, C., Sarmento, R., Saxena, A., Schillebeeckx, P., Schmidt, S., Schumann, D., Tagliente, G., Tain, J. L., Tarrío, D., Tassan-Got, L., Tsinganis, A., Valenta, S., Vannini, G., Variale, V., Vaz, P., Ventura, A., Versaci, R., Vermeulen, M. J., Vlachoudis, V., Vlastou, R., Wallner, A., Ware, T., Weigand, M., Weiß, C., and Wright, T.
Subjects: Physics - Instrumentation and Detectors, Nuclear Experiment
Abstract: The neutron sensitivity of the C$_6$D$_6$ detector setup used at n_TOF for capture measurements has been studied by means of detailed GEANT4 simulations. A realistic software replica of the entire n_TOF experimental hall, including the neutron beam line, sample, detector supports and the walls of the experimental area has been implemented in the simulations. The simulations have been analyzed in the same manner as experimental data, in particular by applying the Pulse Height Weighting Technique. The simulations have been validated against a measurement of the neutron background performed with a $^\mathrm{nat}$C sample, showing an excellent agreement above 1 keV. At lower energies, an additional component in the measured $^\mathrm{nat}$C yield has been discovered, which prevents the use of $^\mathrm{nat}$C data for neutron background estimates at neutron energies below a few hundred eV. The origin and time structure of the neutron background have been derived from the simulations. Examples of the neutron background for two different samples are demonstrating the important role of accurate simulations of the neutron background in capture cross section measurements.
Published: 2014
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33. $^{62}$Ni($n,\gamma$) and $^{63}$Ni($n,\gamma$) cross sections measured at n_TOF/CERN

Author: Lederer, C., Massimi, C., Berthoumieux, E., Colonna, N., Dressler, R., Guerrero, C., Gunsing, F., Käppeler, F., Kivel, N., Pignatari, M., Reifarth, R., Schumann, D., Wallner, A., Altstadt, S., Andriamonje, S., Andrzejewski, J., Audouin, L., Barbagallo, M., Becares, V., Becvar, F., Belloni, F., Berthier, B., Billowes, J., Boccone, V., Bosnar, D., Brugger, M., Calviani, M., Calvino, F., Cano-Ott, D., Carrapico, C., Cerutti, F., Chiaveri, E., Chin, M., Cortes, G., Cortes-Giraldo, M. A., Dillmann, I., Domingo-Pardo, C., Duran, I., Dzysiuk, N., Eleftheriadis, C., Fernandez-Ordonez, M., Ferrari, A., Fraval, K., Ganesan, S., Garcıa, A. R., Giubrone, G., Gomez-Hornillos, M. B., Goncalves, I. F., Gonzalez-Romero, E., Gramegna, F., Griesmayer, E., Gurusamy, P., Harrisopulos, S., Heil, M., Ioannides, K., Jenkins, D. G., Jericha, E., Kadi, Y., Karadimos, D., Korschinek, G., Krticka, M., Kroll, J., Langer, C., Lebbos, E., Leeb, H., Leong, L. S., Losito, R., Lozano, M., Manousos, A., Marganiec, J., Marrone, S., Martinez, T., Mastinu, P. F., Mastromarco, M., Meaze, M., Mendoza, E., Mengoni, A., Milazzo, P. M., Mingrone, F., Mirea, M., Mondalaers, W., Paradela, C., Pavlik, A., Perkowski, J., Plag, R., Plompen, A., Praena, J., Quesada, J. M., Rauscher, T., Riego, A., Roman, F., Rubbia, C., Sarmento, R., Schillebeeckx, P., Schmidt, S., Tagliente, G., Tain, J. L., Tarrıo, D., Tassan-Got, L., Tsinganis, A., Tlustos, L., Valenta, S., Vannini, G., Variale, V., Vaz, P., Ventura, A., Vermeulen, M. J., Versaci, R., Vlachoudis, V., Vlastou, R., Ware, T., Weigand, M., Weiß, C., Wright, T. J., and Zugec, P.
Subjects: Nuclear Experiment
Abstract: The cross section of the $^{62}$Ni($n,\gamma$) reaction was measured with the time-of-flight technique at the neutron time-of-flight facility n_TOF at CERN. Capture kernels of 42 resonances were analyzed up to 200~keV neutron energy and Maxwellian averaged cross sections (MACS) from $kT=5-100$ keV were calculated. With a total uncertainty of 4.5%, the stellar cross section is in excellent agreement with the the KADoNiS compilation at $kT=30$ keV, while being systematically lower up to a factor of 1.6 at higher stellar temperatures. The cross section of the $^{63}$Ni($n,\gamma$) reaction was measured for the first time at n_TOF. We determined unresolved cross sections from 10 to 270 keV with a systematic uncertainty of 17%. These results provide fundamental constraints on $s$-process production of heavier species, especially the production of Cu in massive stars, which serve as the dominant source of Cu in the solar system.
Published: 2014
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34. Transit Search from Antarctica and Chile - Comparison and Combination

Author: Fruth, T., Cabrera, J., Csizmadia, Sz., Dreyer, C., Eigmüller, P., Erikson, A., Kabath, P., Pasternacki, T., Rauer, H., Titz-Weider, R., Abe, L., Agabi, A., Gonçalves, I., Guillot, T., Mékarnia, D., Rivet, J. -P., Crouzet, N., Chini, R., Lemke, R., and Murphy, M.
Subjects: Astrophysics - Instrumentation and Methods for Astrophysics, Astrophysics - Earth and Planetary Astrophysics
Abstract: Observing sites at the East-Antarctic plateau are considered to provide exceptional conditions for astronomy. The aim of this work is to assess its potential for detecting transiting extrasolar planets through a comparison and combination of photometric data from Antarctica with time series from a midlatitude site. During 2010, the two small aperture telescopes ASTEP 400 (Dome C) and BEST II (Chile) together performed an observing campaign of two target fields and the transiting planet WASP-18b. For the latter, a bright star, Dome C appears to yield an advantageous signal-to-noise ratio. For field surveys, both Dome C and Chile appear to be of comparable photometric quality. However, within two weeks, observations at Dome C yield a transit detection efficiency that typically requires a whole observing season in Chile. For the first time, data from Antarctica and Chile have been combined to extent the observational duty cycle. This approach is both feasible in practice and favorable for transit search, as it increases the detection yield by 12-18%., Comment: 22 pages, 12 figures, accepted for publication in PASP (in press)
Published: 2014
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35. Experimental neutron capture data of $^{58}$Ni from the CERN n_TOF facility

Author: collaboration, n_TOF, Žugec, P., Barbagallo, M., Colonna, N., Bosnar, D., Altstadt, S., Andrzejewski, J., Audouin, L., Bécares, V., Bečvář, F., Belloni, F., Berthoumieux, E., Billowes, J., Boccone, V., Brugger, M., Calviani, M., Calviño, F., Cano-Ott, D., Carrapiço, C., Cerutti, F., Chiaveri, E., Chin, M., Cortés, G., Cortés-Giraldo, M. A., Diakaki, M., Domingo-Pardo, C., Duran, I., Dzysiuk, N., Eleftheriadis, C., Ferrari, A., Fraval, K., Ganesan, S., García, A. R., Giubrone, G., Gómez-Hornillos, M. B., Gonçalves, I. F., González-Romero, E., Griesmayer, E., Guerrero, C., Gunsing, F., Gurusamy, P., Jenkins, D. G., Jericha, E., Kadi, Y., Käppeler, F., Karadimos, D., Koehler, P., Kokkoris, M., Krtička, M., Kroll, J., Langer, C., Lederer, C., Leeb, H., Leong, L. S., Losito, R., Manousos, A., Marganiec, J., Martìnez, T., Massimi, C., Mastinu, P. F., Mastromarco, M., Meaze, M., Mendoza, E., Mengoni, A., Milazzo, P. M., Mingrone, F., Mirea, M., Mondalaers, W., Paradela, C., Pavlik, A., Perkowski, J., Pignatari, M., Plompen, A., Praena, J., Quesada, J. M., Rauscher, T., Reifarth, R., Riego, A., Roman, F., Rubbia, C., Sarmento, R., Schillebeeckx, P., Schmidt, S., Tagliente, G., Tain, J. L., Tarrío, D., Tassan-Got, L., Tsinganis, A., Valenta, S., Vannini, G., Variale, V., Vaz, P., Ventura, A., Versaci, R., Vermeulen, M. J., Vlachoudis, V., Vlastou, R., Wallner, A., Ware, T., Weigand, M., Weiß, C., and Wright, T.
Subjects: Nuclear Experiment
Abstract: The $^{58}$Ni $(n,\gamma)$ cross section has been measured at the neutron time of flight facility n_TOF at CERN, in the energy range from 27 meV up to 400 keV. In total, 51 resonances have been analyzed up to 122 keV. Maxwellian averaged cross sections (MACS) have been calculated for stellar temperatures of kT$=$5-100 keV with uncertainties of less than 6%, showing fair agreement with recent experimental and evaluated data up to kT = 50 keV. The MACS extracted in the present work at 30 keV is 34.2$\pm$0.6$_\mathrm{stat}\pm$1.8$_\mathrm{sys}$ mb, in agreement with latest results and evaluations, but 12% lower relative to the recent KADoNIS compilation of astrophysical cross sections. When included in models of the s-process nucleosynthesis in massive stars, this change results in a 60% increase of the abundance of $^{58}$Ni, with a negligible propagation on heavier isotopes. The reason is that, using both the old or the new MACS, 58Ni is efficiently depleted by neutron captures., Comment: 10 pages, 8 figures, 5 tables
Published: 2014
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36. Pragmatic solutions to reduce the global burden of stroke: a World Stroke Organization–Lancet Neurology Commission

Author: Feigin, V, Owolabi, M, Abd-Allah, F, Akinyemi, R, Bhattacharjee, N, Brainin, M, Cao, J, Caso, V, Dalton, B, Davis, A, Dempsey, R, Duprey, J, Feng, W, Ford, G, Gall, S, Gandhi, D, Good, D, Hachinski, V, Hacke, W, Hankey, G, Ishida, M, Johnson, W, Kim, J, Lavados, P, Lindsay, P, Mahal, A, Martins, S, Murray, C, Nguyen, T, Norrving, B, Olaiya, M, Olalusi, O, Pandian, J, Phan, H, Platz, T, Ranta, A, Rehman, S, Roth, G, Sebastian, I, Smith, A, Suwanwela, N, Sylaja, P, Thapa, R, Thrift, A, Uvere, E, Vollset, S, Yavagal, D, Yaria, J, Abera, S, Ibrahim, N, Liu, L, Ovbiagele, B, Piradov, M, Abanto, C, Addissie, A, Adeleye, A, Adilbekov, Y, Adilbekova, B, Adoukonou, T, Aguiar de Sousa, D, Akhmetzhanova, Z, Akpalu, A, El Alaoui-Faris, M, Ameriso, S, Andonova, S, Arsovska, A, Awoniyi, F, Bakhiet, M, Barboza, M, Basri, H, Bath, P, Bereczki, D, Beretta, S, Berkowitz, A, Bernhardt, J, Berzina, G, Bhavsar, B, Bisharyan, M, Bohara, M, Bovet, P, Budincevic, H, Cadilhac, D, Cerimagic, D, Charway-Felli, A, Chen, C, Chin, J, Christensen, H, Chwojnicki, K, Conforto, A, Correia, M, Mora Cuervo, D, Czlonkowska, A, D'Amelio, M, Danielyan, K, Davis, S, Demarin, V, Demchuk, A, Dichgans, M, Dokova, K, Donnan, G, Duran, J, Ekeng, G, Elkind, M, Endres, M, Fischer, U, Flomin, Y, Gankpe, F, Gavidia, M, Gaye Saavedra, A, Gebreyohanns, M, George, M, Gierlotka, M, Giroud, M, Gnedovskaya, E, Goncalves, I, Gongora-Rivera, F, Gunaratne, P, Hamadeh, R, Hamzat, T, Heldner, M, Ibrahim, E, Ihle-Hansen, H, Jee, S, Jiann-Shing, J, Johnston, S, Jovanovic, D, Jurjans, K, Kalani, R, Kalkonde, Y, Kamenova, S, Karaszewski, B, Kelly, P, Kiechl, S, Kondybayeva, A, Korv, J, Kozera, G, Kravchenko, M, Krespi, Y, Krishnamurthi, R, Kruja, J, Kutluk, K, Langhorne, P, Law, Z, Lebedynets, D, Lee, T, Leung, T, Liebeskind, D, Lopez-Jaramillo, P, Lotufo, P, Machline-Carrion, M, Maia, L, Malojcic, B, Markus, H, Marquez-Romero, J, Medina, M, Medukhanova, S, Mehndiratta, M, Miglane, E, Mihejeva, I, Mikulik, R, Mirrakhimov, E, Mohl, S, Munakomi, S, Murphy, S, Musa, K, Nasreldein, A, Nogueira, R, Nolte, C, Noubiap, J, Novarro-Escudero, N, Ocampo, C, O'Donnell, M, Ogun, Y, Ogunniyi, A, Oraby, M, Orken, D, Ozdemir, A, Ozturk, S, Paccot, M, Pereira, T, Peeters, A, Potpara, T, Proios, H, Rathore, F, Sacco, R, Sahathevan, R, Sandset, E, Renato Santos, I, Saposnik, G, Sarfo, F, Sargento-Freitas, J, Sharma, M, Shaw, L, Sheth, K, Shin, Y, Shobhana, A, Silva, S, Tedim Cruz, V, Thakur, K, Thapa, L, Toni, D, Topcuoglu, M, Torales, J, Towfighi, A, Truelsen, T, Tsiskaridze, A, Tulloch-Reid, M, Useche, J, Vanacker, P, Vassilopoulou, S, Vukorepa, G, Vuletic, V, Wahab, K, Wang, W, Wijeratne, T, Wojtyniak, B, Wolfe, C, Yacouba, M, Yang, J, Yifru, Y, Yock-Corrales, A, Yonemoto, N, Yperzeele, L, Zagozdzon, P, Feigin V. L., Owolabi M. O., Abd-Allah F., Akinyemi R. O., Bhattacharjee N. V., Brainin M., Cao J., Caso V., Dalton B., Davis A., Dempsey R., Duprey J., Feng W., Ford G. A., Gall S., Gandhi D., Good D. C., Hachinski V., Hacke W., Hankey G. J., Ishida M., Johnson W., Kim J., Lavados P., Lindsay P., Mahal A., Martins S., Murray C., Nguyen T. P., Norrving B., Olaiya M. T., Olalusi O. V., Pandian J., Phan H., Platz T., Ranta A., Rehman S., Roth G., Sebastian I. A., Smith A. E., Suwanwela N. C., Sylaja P. N., Thapa R., Thrift A. G., Uvere E., Vollset S. E., Yavagal D., Yaria J., Abera S. F., Akinyemi R., Dempsey R. J., Ibrahim N. M., Liu L., Ovbiagele B., Piradov M., Suwanwela N., Abanto C., Addissie A., Adeleye A. O., Adilbekov Y., Adilbekova B., Adoukonou T. A., Aguiar de Sousa D., Akhmetzhanova Z., Akpalu A., El Alaoui-Faris M., Ameriso S. F., Andonova S., Arsovska A., Awoniyi F. E., Bakhiet M., Barboza M. A., Basri H., Bath P. M., Bereczki D., Beretta S., Berkowitz A. L., Bernhardt J., Berzina G., Bhavsar B., Bisharyan M. S., Bohara M., Bovet P., Budincevic H., Cadilhac D. A., Cerimagic D., Charway-Felli A., Chen C., Chin J. H., Christensen H., Chwojnicki K., Conforto A. B., Correia M., Mora Cuervo D. L., Czlonkowska A., D'Amelio M., Danielyan K. E., Davis S., Demarin V., Demchuk A. M., Dichgans M., Dokova K., Donnan G., Duran J. C., Ekeng G., Elkind M. S., Endres M., Fischer U., Flomin Y., Gankpe F., Gavidia M., Gaye Saavedra A., Gebreyohanns M., George M., Gierlotka M., Giroud M., Gnedovskaya E. V., Goncalves I. P., Gongora-Rivera F., Gunaratne P. S., Hamadeh R. R., Hamzat T. -H. K., Heldner M. R., Ibrahim E., Ihle-Hansen H., Jee S., Jiann-Shing J., Johnston S. C., Jovanovic D., Jurjans K., Kalani R., Kalkonde Y., Kamenova S., Karaszewski B., Kelly P., Kiechl S., Kondybayeva A., Korv J., Kozera G., Kravchenko M., Krespi Y., Krishnamurthi R., Kruja J., Kutluk K., Langhorne P., Law Z. K., Lebedynets D., Lee T. -H., Leung T. W., Liebeskind D. S., Lopez-Jaramillo P., Lotufo P. A., Machline-Carrion M. J., Maia L. F., Malojcic B., Markus H. S., Marquez-Romero J. M., Medina M. T., Medukhanova S., Mehndiratta M. M., Miglane E., Mihejeva I., Mikulik R., Mirrakhimov E., Mohl S., Munakomi S., Murphy S., Musa K. I., Nasreldein A., Nogueira R. G., Nolte C. H., Noubiap J. J., Novarro-Escudero N., Ocampo C., O'Donnell M., Ogun Y., Ogunniyi A., Oraby M. I., Orken D. N., Ozdemir A. O., Ozturk S., Paccot M., Pereira T., Peeters A., Potpara T., Proios H., Rathore F. A., Sacco R. L., Sahathevan R., Sandset E. S., Renato Santos I., Saposnik G., Sarfo F. S., Sargento-Freitas J., Sharma M., Shaw L., Sheth K. N., Shin Y. -I., Shobhana A., Silva S. N., Tedim Cruz V., Thakur K., Thapa L. J., Toni D., Topcuoglu M. A., Torales J., Towfighi A., Truelsen T., Tsiskaridze A., Tulloch-Reid M., Useche J. N., Vanacker P., Vassilopoulou S., Vukorepa G., Vuletic V., Wahab K. W., Wang W., Wijeratne T., Wojtyniak B., Wolfe C., Yacouba M. N., Yang J., Yifru Y. M., Yock-Corrales A., Yonemoto N., Yperzeele L., Zagozdzon P., Feigin, V, Owolabi, M, Abd-Allah, F, Akinyemi, R, Bhattacharjee, N, Brainin, M, Cao, J, Caso, V, Dalton, B, Davis, A, Dempsey, R, Duprey, J, Feng, W, Ford, G, Gall, S, Gandhi, D, Good, D, Hachinski, V, Hacke, W, Hankey, G, Ishida, M, Johnson, W, Kim, J, Lavados, P, Lindsay, P, Mahal, A, Martins, S, Murray, C, Nguyen, T, Norrving, B, Olaiya, M, Olalusi, O, Pandian, J, Phan, H, Platz, T, Ranta, A, Rehman, S, Roth, G, Sebastian, I, Smith, A, Suwanwela, N, Sylaja, P, Thapa, R, Thrift, A, Uvere, E, Vollset, S, Yavagal, D, Yaria, J, Abera, S, Ibrahim, N, Liu, L, Ovbiagele, B, Piradov, M, Abanto, C, Addissie, A, Adeleye, A, Adilbekov, Y, Adilbekova, B, Adoukonou, T, Aguiar de Sousa, D, Akhmetzhanova, Z, Akpalu, A, El Alaoui-Faris, M, Ameriso, S, Andonova, S, Arsovska, A, Awoniyi, F, Bakhiet, M, Barboza, M, Basri, H, Bath, P, Bereczki, D, Beretta, S, Berkowitz, A, Bernhardt, J, Berzina, G, Bhavsar, B, Bisharyan, M, Bohara, M, Bovet, P, Budincevic, H, Cadilhac, D, Cerimagic, D, Charway-Felli, A, Chen, C, Chin, J, Christensen, H, Chwojnicki, K, Conforto, A, Correia, M, Mora Cuervo, D, Czlonkowska, A, D'Amelio, M, Danielyan, K, Davis, S, Demarin, V, Demchuk, A, Dichgans, M, Dokova, K, Donnan, G, Duran, J, Ekeng, G, Elkind, M, Endres, M, Fischer, U, Flomin, Y, Gankpe, F, Gavidia, M, Gaye Saavedra, A, Gebreyohanns, M, George, M, Gierlotka, M, Giroud, M, Gnedovskaya, E, Goncalves, I, Gongora-Rivera, F, Gunaratne, P, Hamadeh, R, Hamzat, T, Heldner, M, Ibrahim, E, Ihle-Hansen, H, Jee, S, Jiann-Shing, J, Johnston, S, Jovanovic, D, Jurjans, K, Kalani, R, Kalkonde, Y, Kamenova, S, Karaszewski, B, Kelly, P, Kiechl, S, Kondybayeva, A, Korv, J, Kozera, G, Kravchenko, M, Krespi, Y, Krishnamurthi, R, Kruja, J, Kutluk, K, Langhorne, P, Law, Z, Lebedynets, D, Lee, T, Leung, T, Liebeskind, D, Lopez-Jaramillo, P, Lotufo, P, Machline-Carrion, M, Maia, L, Malojcic, B, Markus, H, Marquez-Romero, J, Medina, M, Medukhanova, S, Mehndiratta, M, Miglane, E, Mihejeva, I, Mikulik, R, Mirrakhimov, E, Mohl, S, Munakomi, S, Murphy, S, Musa, K, Nasreldein, A, Nogueira, R, Nolte, C, Noubiap, J, Novarro-Escudero, N, Ocampo, C, O'Donnell, M, Ogun, Y, Ogunniyi, A, Oraby, M, Orken, D, Ozdemir, A, Ozturk, S, Paccot, M, Pereira, T, Peeters, A, Potpara, T, Proios, H, Rathore, F, Sacco, R, Sahathevan, R, Sandset, E, Renato Santos, I, Saposnik, G, Sarfo, F, Sargento-Freitas, J, Sharma, M, Shaw, L, Sheth, K, Shin, Y, Shobhana, A, Silva, S, Tedim Cruz, V, Thakur, K, Thapa, L, Toni, D, Topcuoglu, M, Torales, J, Towfighi, A, Truelsen, T, Tsiskaridze, A, Tulloch-Reid, M, Useche, J, Vanacker, P, Vassilopoulou, S, Vukorepa, G, Vuletic, V, Wahab, K, Wang, W, Wijeratne, T, Wojtyniak, B, Wolfe, C, Yacouba, M, Yang, J, Yifru, Y, Yock-Corrales, A, Yonemoto, N, Yperzeele, L, Zagozdzon, P, Feigin V. L., Owolabi M. O., Abd-Allah F., Akinyemi R. O., Bhattacharjee N. V., Brainin M., Cao J., Caso V., Dalton B., Davis A., Dempsey R., Duprey J., Feng W., Ford G. A., Gall S., Gandhi D., Good D. C., Hachinski V., Hacke W., Hankey G. J., Ishida M., Johnson W., Kim J., Lavados P., Lindsay P., Mahal A., Martins S., Murray C., Nguyen T. P., Norrving B., Olaiya M. T., Olalusi O. V., Pandian J., Phan H., Platz T., Ranta A., Rehman S., Roth G., Sebastian I. A., Smith A. E., Suwanwela N. C., Sylaja P. N., Thapa R., Thrift A. G., Uvere E., Vollset S. E., Yavagal D., Yaria J., Abera S. F., Akinyemi R., Dempsey R. J., Ibrahim N. M., Liu L., Ovbiagele B., Piradov M., Suwanwela N., Abanto C., Addissie A., Adeleye A. O., Adilbekov Y., Adilbekova B., Adoukonou T. A., Aguiar de Sousa D., Akhmetzhanova Z., Akpalu A., El Alaoui-Faris M., Ameriso S. F., Andonova S., Arsovska A., Awoniyi F. E., Bakhiet M., Barboza M. A., Basri H., Bath P. M., Bereczki D., Beretta S., Berkowitz A. L., Bernhardt J., Berzina G., Bhavsar B., Bisharyan M. S., Bohara M., Bovet P., Budincevic H., Cadilhac D. A., Cerimagic D., Charway-Felli A., Chen C., Chin J. H., Christensen H., Chwojnicki K., Conforto A. B., Correia M., Mora Cuervo D. L., Czlonkowska A., D'Amelio M., Danielyan K. E., Davis S., Demarin V., Demchuk A. M., Dichgans M., Dokova K., Donnan G., Duran J. C., Ekeng G., Elkind M. S., Endres M., Fischer U., Flomin Y., Gankpe F., Gavidia M., Gaye Saavedra A., Gebreyohanns M., George M., Gierlotka M., Giroud M., Gnedovskaya E. V., Goncalves I. P., Gongora-Rivera F., Gunaratne P. S., Hamadeh R. R., Hamzat T. -H. K., Heldner M. R., Ibrahim E., Ihle-Hansen H., Jee S., Jiann-Shing J., Johnston S. C., Jovanovic D., Jurjans K., Kalani R., Kalkonde Y., Kamenova S., Karaszewski B., Kelly P., Kiechl S., Kondybayeva A., Korv J., Kozera G., Kravchenko M., Krespi Y., Krishnamurthi R., Kruja J., Kutluk K., Langhorne P., Law Z. K., Lebedynets D., Lee T. -H., Leung T. W., Liebeskind D. S., Lopez-Jaramillo P., Lotufo P. A., Machline-Carrion M. J., Maia L. F., Malojcic B., Markus H. S., Marquez-Romero J. M., Medina M. T., Medukhanova S., Mehndiratta M. M., Miglane E., Mihejeva I., Mikulik R., Mirrakhimov E., Mohl S., Munakomi S., Murphy S., Musa K. I., Nasreldein A., Nogueira R. G., Nolte C. H., Noubiap J. J., Novarro-Escudero N., Ocampo C., O'Donnell M., Ogun Y., Ogunniyi A., Oraby M. I., Orken D. N., Ozdemir A. O., Ozturk S., Paccot M., Pereira T., Peeters A., Potpara T., Proios H., Rathore F. A., Sacco R. L., Sahathevan R., Sandset E. S., Renato Santos I., Saposnik G., Sarfo F. S., Sargento-Freitas J., Sharma M., Shaw L., Sheth K. N., Shin Y. -I., Shobhana A., Silva S. N., Tedim Cruz V., Thakur K., Thapa L. J., Toni D., Topcuoglu M. A., Torales J., Towfighi A., Truelsen T., Tsiskaridze A., Tulloch-Reid M., Useche J. N., Vanacker P., Vassilopoulou S., Vukorepa G., Vuletic V., Wahab K. W., Wang W., Wijeratne T., Wojtyniak B., Wolfe C., Yacouba M. N., Yang J., Yifru Y. M., Yock-Corrales A., Yonemoto N., Yperzeele L., and Zagozdzon P.
Published: 2023

37. Neutron capture cross section of unstable 63Ni: implications for stellar nucleosynthesis

Author: Lederer, C., Massimi, C., Altstadt, S., Andrzejewski, J., Audouin, L., Barbagallo, M., Bécares, V., Bevá, F., Belloni, F., Berthoumieux, E., Billowes, J., Boccone, V., Bosnar, D., Brugger, M., Calviani, M., Calviño, F., Cano-Ott, D., Carrapiço, C., Cerutti, F., Chiaveri, E., Chin, M., Colonna, N., Cortés, G., Cortés-Giraldo, M. A., Diakaki, M., Domingo-Pardo, C., Duran, I., Dressler, R., Dzysiuk, N., Eleftheriadis, C., Ferrari, A., Fraval, K., Ganesan, S., García, A. R., Giubrone, G., Gómez-Hornillos, M. B., Gonçalves, I. F., González-Romero, E., Griesmayer, E., Guerrero, C., Gunsing, F., Gurusamy, P., Jenkins, D. G., Jericha, E., Kadi, Y., Käppeler, F., Karadimos, D., Kivel, N., Koehler, P., Kokkoris, M., Korschinek, G., Krtika, M., Kroll, J., Langer, C., Leeb, H., Leong, L. S., Losito, R., Manousos, A., Marganiec, J., Martínez, T., Mastinu, P. F., Mastromarco, M., Meaze, M., Mendoza, E., Mengoni, A., Milazzo, P. M., Mingrone, F., Mirea, M., Mondelaers, W., Paradela, C., Pavlik, A., Perkowski, J., Pignatari, M., Plompen, A., Praena, J., Quesada, J. M., Rauscher, T., Reifarth, R., Riego, A., Roman, F., Rubbia, C., Sarmento, R., Schillebeeckx, P., Schmidt, S., Schumann, D., Tagliente, G., Tain, J. L., Tarrío, D., Tassan-Got, L., Tsinganis, A., Valenta, S., Vannini, G., Variale, V., Vaz, P., Ventura, A., Versaci, R., Vermeulen, M. J., Vlachoudis, V., Vlastou, R., Wallner, A., Ware, T., Weigand, M., Weiß, C., Wright, T. J., and Zugec, P.
Subjects: Nuclear Experiment, Astrophysics - Solar and Stellar Astrophysics
Abstract: The $^{63}$Ni($n, \gamma$) cross section has been measured for the first time at the neutron time-of-flight facility n\_TOF at CERN from thermal neutron energies up to 200 keV. In total, capture kernels of 12 (new) resonances were determined. Maxwellian Averaged Cross Sections were calculated for thermal energies from kT = 5 keV to 100 keV with uncertainties around 20%. Stellar model calculations for a 25 M$_\odot$ star show that the new data have a significant effect on the $s$-process production of $^{63}$Cu, $^{64}$Ni, and $^{64}$Zn in massive stars, allowing stronger constraints on the Cu yields from explosive nucleosynthesis in the subsequent supernova.
Published: 2013
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38. The secondary eclipses of WASP-19b as seen by the ASTEP 400 telescope from Antarctica

Author: Abe, L., Gonçalves, I., Agabi, A., Alapini, A., Guillot, T., Mékarnia, D., Rivet, J. -P., Schmider, F. -X., Crouzet, N., Fortney, J., Pont, F., Barbieri, M., Daban, J. -B., Fanteï-Caujolle, Y., Gouvret, C., Bresson, Y., Roussel, A., Bonhomme, S., Robini, A., Dugué, M., Bondoux, E., Péron, S., Petit, P. -Y., Szulágyi, J., Fruth, T., Erikson, A., Rauer, H., Fressin, F., Valbousquet, F., Blanc, P. -E., van Suu, A. Le, and Aigrain, S.
Subjects: Astrophysics - Earth and Planetary Astrophysics
Abstract: The ASTEP (Antarctica Search for Transiting ExoPlanets) program was originally aimed at probing the quality of the Dome C, Antarctica for the discovery and characterization of exoplanets by photometry. In the first year of operation of the 40 cm ASTEP 400 telescope (austral winter 2010), we targeted the known transiting planet WASP-19b in order to try to detect its secondary transits in the visible. This is made possible by the excellent sub-millimagnitude precision of the binned data. The WASP-19 system was observed during 24 nights in May 2010. The photometric variability level due to starspots is about 1.8% (peak-to-peak), in line with the SuperWASP data from 2007 (1.4%) and larger than in 2008 (0.07%). We find a rotation period of WASP-19 of 10.7 +/- 0.5 days, in agreement with the SuperWASP determination of 10.5 +/- 0.2 days. Theoretical models show that this can only be explained if tidal dissipation in the star is weak, i.e. the tidal dissipation factor Q'star > 3.10^7. Separately, we find evidence for a secondary eclipse of depth 390 +/- 190 ppm with a 2.0 sigma significance, a phase consistent with a circular orbit and a 3% false positive probability. Given the wavelength range of the observations (420 to 950 nm), the secondary transit depth translates into a day side brightness temperature of 2690(-220/+150) K, in line with measurements in the z' and K bands. The day side emission observed in the visible could be due either to thermal emission of an extremely hot day side with very little redistribution of heat to the night side, or to direct reflection of stellar light with a maximum geometrical albedo Ag=0.27 +/- 0.13. We also report a low-frequency oscillation well in phase at the planet orbital period, but with a lower-limit amplitude that could not be attributed to the planet phase alone, and possibly contaminated with residual lightcurve trends., Comment: Accepted for publication in Astronomy and Astrophysics, 13 pages, 13 figures
Published: 2013
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39. ASTEP South: a first photometric analysis

Author: Crouzet, N., Guillot, T., Mékarnia, D., Szulágyi, J., Abe, L., Agabi, A., Fanteï-Caujolle, Y., Gonçalves, I., Barbieri, M., Schmider, F. -X., Rivet, J. -P., Bondoux, E., Challita, Z., Pouzenc, C., Fressin, F., Valbousquet, F., Blazit, A., Bonhomme, S., Daban, J. -B., Gouvret, C., Bayliss, D., Zhou, G., and team, the ASTEP
Subjects: Astrophysics - Instrumentation and Methods for Astrophysics, Astrophysics - Earth and Planetary Astrophysics
Abstract: The ASTEP project aims at detecting and characterizing transiting planets from Dome C, Antarctica, and qualifying this site for photometry in the visible. The first phase of the project, ASTEP South, is a fixed 10 cm diameter instrument pointing continuously towards the celestial South pole. Observations were made almost continuously during 4 winters, from 2008 to 2011. The point-to-point RMS of 1-day photometric lightcurves can be explained by a combination of expected statistical noises, dominated by the photon noise up to magnitude 14. This RMS is large, from 2.5 mmag at R=8 to 6% at R=14, because of the small size of ASTEP South and the short exposure time (30 s). Statistical noises should be considerably reduced using the large amount of collected data. A 9.9-day period eclipsing binary is detected, with a magnitude R=9.85. The 2-season lightcurve folded in phase and binned into 1000 points has a RMS of 1.09 mmag, for an expected photon noise of 0.29 mmag. The use of the 4 seasons of data with a better detrending algorithm should yield a sub-millimagnitude precision for this folded lightcurve. Radial velocity follow-up observations are conducted and reveal a F-M binary system. The detection of this 9.9-day period system with a small instrument such as ASTEP South and the precision of the folded lightcurve show the quality of Dome C for continuous photometric observations, and its potential for the detection of planets with orbital period longer than those usually detected from the ground., Comment: 5 pages, 3 figures, IAUS 288 conference proceedings
Published: 2012
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40. Self-Report Tool for Identification of Individuals With Coronary Atherosclerosis: The Swedish CardioPulmonary BioImage Study.

Author: Bergström G, Hagberg E, Björnson E, Adiels M, Bonander C, Strömberg U, Andersson J, Brunström M, Carlhäll CJ, Engström G, Erlinge D, Goncalves I, Gummesson A, Hagström E, Hjelmgren O, James S, Janzon M, Jonasson L, Lind L, Magnusson M, Oskarsson V, Sundström J, Svensson P, Söderberg S, Themudo R, Östgren CJ, and Jernberg T
Subjects: Humans, Middle Aged, Female, Male, Sweden epidemiology, Risk Assessment, Vascular Calcification diagnostic imaging, Vascular Calcification epidemiology, Predictive Value of Tests, Severity of Illness Index, Reproducibility of Results, Coronary Artery Disease diagnostic imaging, Coronary Artery Disease epidemiology, Coronary Artery Disease diagnosis, Computed Tomography Angiography, Coronary Angiography methods, Self Report
Abstract: Background: Coronary atherosclerosis detected by imaging is a marker of elevated cardiovascular risk. However, imaging involves large resources and exposure to radiation. The aim was, therefore, to test whether nonimaging data, specifically data that can be self-reported, could be used to identify individuals with moderate to severe coronary atherosclerosis., Methods and Results: We used data from the population-based SCAPIS (Swedish CardioPulmonary BioImage Study) in individuals with coronary computed tomography angiography (n=25 182) and coronary artery calcification score (n=28 701), aged 50 to 64 years without previous ischemic heart disease. We developed a risk prediction tool using variables that could be assessed from home (self-report tool). For comparison, we also developed a tool using variables from laboratory tests, physical examinations, and self-report (clinical tool) and evaluated both models using receiver operating characteristic curve analysis, external validation, and benchmarked against factors in the pooled cohort equation. The self-report tool (n=14 variables) and the clinical tool (n=23 variables) showed high-to-excellent discriminative ability to identify a segment involvement score ≥4 (area under the curve 0.79 and 0.80, respectively) and significantly better than the pooled cohort equation (area under the curve 0.76, P <0.001). The tools showed a larger net benefit in clinical decision-making at relevant threshold probabilities. The self-report tool identified 65% of all individuals with a segment involvement score ≥4 in the top 30% of the highest-risk individuals. Tools developed for coronary artery calcification score ≥100 performed similarly., Conclusions: We have developed a self-report tool that effectively identifies individuals with moderate to severe coronary atherosclerosis. The self-report tool may serve as prescreening tool toward a cost-effective computed tomography-based screening program for high-risk individuals.
Published: 2024
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41. LIGHT/TNFSF14 levels in carotid atherosclerotic plaques are associated with symptomatic cerebrovascular disease

Author: Shami, A, primary, Edsfeldt, A, additional, Nilsson, J, additional, and Goncalves, I, additional
Published: 2023
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42. High levels of intermediate cd14++cd16+ monocytes predict incident atrial fibrillation in the general population

Author: Sveen, K A, primary, Smith, G, additional, Goncalves, I, additional, Edsfeldt, A, additional, Engstrom, G, additional, Bjorkbacka, H, additional, and Bengtsson, E, additional
Published: 2023
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43. Haptoglobin 1 gene polymorphism protects against postoperative cardiovascular events

Author: Mohsen, Y, primary, Shami, A, additional, Edsfeldt, A, additional, Sun, J, additional, and Goncalves, I, additional
Published: 2023
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44. Imaging signs of vulnerability, neurological events and cognitive impairment in asymptomatic carotid artery stenosis: results from the Carotid Artery Multi-modality imaging Prognostic (CAMP) study

Author: Gargani, L, primary, Masini, G, additional, Baldini, M, additional, Napoli, V, additional, Orlandi, G, additional, Lucchi, G, additional, Totaro, P, additional, D'amelio, C, additional, Galeotti, G G, additional, Ghicopulos, I, additional, Nilsson, I, additional, Goncalves, I, additional, Palombo, C, additional, Cosottini, M, additional, and De Caterina, R, additional
Published: 2023
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45. PB1332 Heightened Thrombosis in Immune Thrombocytopenia: Insights into the Risk Factors and Clinical Outcomes from an Australian Hospital Cohort

Author: Goncalves, I., primary, Mason, K., additional, Szer, J., additional, Dring, R., additional, Grainger, B., additional, Lewis, C., additional, Lee, N., additional, and Howe, R., additional
Published: 2023
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46. Updated treatment options for immune thrombocytopenia.

Author: Choi P, Merriman E, Bennett A, Enjeti A, Tan CW, Goncalves I, Hsu D, and Bird R
Subjects: Humans, Purpura, Thrombocytopenic, Idiopathic diagnosis, Purpura, Thrombocytopenic, Idiopathic drug therapy, Thrombocytopenia
Published: 2024
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47. Clinical and molecular markers in COPD

Author: Gonçalves, I., Guimarães, M.J., van Zeller, M., Menezes, F., Moita, J., and Simão, P.
Published: 2018
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48. Translational opportunities of single-cell biology in atherosclerosis

Author: de Winther, MPJ, Bäck, M, Evans, P, Gomez, D, Goncalves, I, Jørgensen, HF, Koenen, RR, Lutgens, E, Norata, GD, Osto, E, Dib, L, Simons, M, Stellos, K, Ylä-Herttuala, S, Winkels, H, Bochaton-Piallat, M-L, Monaco, C, and University of Zurich
Subjects: 540 Chemistry, 10209 Clinic for Cardiology, 610 Medicine & health, Cardiology and Cardiovascular Medicine, 10038 Institute of Clinical Chemistry
Abstract: The advent of single-cell biology opens a new chapter for understanding human biological processes and for diagnosing, monitoring, and treating disease. This revolution now reaches the field of cardiovascular disease (CVD). New technologies to interrogate CVD samples at single-cell resolution are allowing the identification of novel cell communities that are important in shaping disease development and direct towards new therapeutic strategies. These approaches have begun to revolutionize atherosclerosis pathology and redraw our understanding of disease development. This review discusses the state-of-the-art of single-cell analysis of atherosclerotic plaques, with a particular focus on human lesions, and presents the current resolution of cellular subpopulations and their heterogeneity and plasticity in relation to clinically relevant features. Opportunities and pitfalls of current technologies as well as the clinical impact of single-cell technologies in CVD patient care are highlighted, advocating for multidisciplinary and international collaborative efforts to join the cellular dots of CVD.
Published: 2022
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49. Nuclear Data for the Thorium Fuel Cycle and the Transmutation of Nuclear Waste

Author: Gunsing, F., Altstadt, S., Andrzejewski, J., Audouin, L., Barbagallo, M., Bécares, V., Bečvář, F., Belloni, F., Berthoumieux, E., Billowes, J., Boccone, V., Bosnar, D., Brugger, M., Calviani, M., Calviño, F., Cano-Ott, D., Carrapiço, C., Cerutti, F., Chiaveri, E., Chin, M., Colonna, N., Cortés, G., Cortés-Giraldo, M. A., Diakaki, M., Domingo-Pardo, C., Duran, I., Dressler, R., Eleftheriadis, C., Fraval, K., Ferrari, A., Ganesan, S., Garcìa, A. R., Giubrone, G., Gonçalves, I. F., González-Romero, E., Griesmayer, E., Guerrero, C., Hernández-Prieto, A., Jenkins, D. G., Jericha, E., Kadi, Y., Käppeler, F., Karadimos, D., Kivel, N., Koehler, P., Kokkoris, M., Krtička, M., Kroll, J., Lampoudis, C., Langer, C., Leal-Cidoncha, E., Lederer, C., Leeb, H., Leong, L. S., Losito, R., Mallick, A., Manousos, A., Marganiec, J., Martìnez, T., Massimi, C., Mastinu, P. F., Mastromarco, M., Mendoza, E., Mengoni, A., Milazzo, P. M., Mingrone, F., Mirea, M., Mondalaers, W., Paradela, C., Pavlik, A., Perkowski, J., Plompen, A., Praena, J., Quesada, J. M., Rauscher, T., Reifarth, R., Riego, A., Robles, M. S., Rubbia, C., Sabaté-Gilarte, M., Sarmento, R., Saxena, A., Schillebeeckx, P., Schmidt, S., Schumann, D., Tagliente, G., Tain, J. L., Tarrìo, D., Tassan-Got, L., Tsinganis, A., Vannini, G., Variale, V., Vaz, P., Ventura, A., Vermeulen, M. J., Valenta, S., Vlachoudis, V., Vlastou, R., Wallner, A., Ware, T., Weigand, M., Weiß, C., Wright, T., Žugec, P., Revol, Jean-Pierre, editor, Bourquin, Maurice, editor, Kadi, Yacine, editor, Lillestol, Egil, editor, de Mestral, Jean-Christophe, editor, and Samec, Karel, editor
Published: 2016
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50. ADAM-17 Activity and Its Relation to ACE2: Implications for Severe COVID-19.

Author: Sun J, Edsfeldt A, Svensson J, Ruge T, Goncalves I, and Swärd P
Subjects: Humans, Middle Aged, Female, Male, Aged, Adult, Aged, 80 and over, Young Adult, Biomarkers blood, COVID-19 virology, COVID-19 metabolism, COVID-19 genetics, COVID-19 pathology, ADAM17 Protein metabolism, ADAM17 Protein genetics, Angiotensin-Converting Enzyme 2 metabolism, Angiotensin-Converting Enzyme 2 genetics, SARS-CoV-2, Severity of Illness Index
Abstract: There is a lack of studies aiming to assess cellular a disintegrin and metalloproteinase-17 (ADAM-17) activity in COVID-19 patients and the eventual associations with the shedding of membrane-bound angiotensin-converting enzyme 2 (mACE2). In addition, studies that investigate the relationship between ACE2 and ADAM-17 gene expressions in organs infected by SARS-CoV-2 are lacking. We used data from the Massachusetts general hospital COVID-19 study (306 COVID-19 patients and 78 symptomatic controls) to investigate the association between plasma levels of 33 different ADAM-17 substrates and COVID-19 severity and mortality. As a surrogate of cellular ADAM-17 activity, an ADAM-17 substrate score was calculated. The associations between soluble ACE2 (sACE2) and the ADAM-17 substrate score, renin, key inflammatory markers, and lung injury markers were investigated. Furthermore, we used data from the Genotype-Tissue Expression (GTEx) database to evaluate ADAM-17 and ACE2 gene expressions by age and sex in ages between 20-80 years. We found that increased ADAM-17 activity, as estimated by the ADAM-17 substrates score, was associated with COVID-19 severity ( p = 0.001). ADAM-17 activity was also associated with increased mortality but did not reach statistical significance ( p = 0.06). Soluble ACE2 showed the strongest positive correlation with the ADAM-17 substrate score, follow by renin, interleukin-6, and lung injury biomarkers. The ratio of ADAM-17 to ACE2 gene expression was highest in the lung. This study indicates that increased ADAM-17 activity is associated with severe COVID-19. Our findings also indicate that there may a bidirectional relationship between membrane-bound ACE2 shedding via increased ADAM-17 activity, dysregulated renin-angiotensin system (RAS) and immune signaling. Additionally, differences in ACE2 and ADAM-17 gene expressions between different tissues may be of importance in explaining why the lung is the organ most severely affected by COVID-19, but this requires further evaluation in prospective studies.
Published: 2024
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