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5 results on '"García-Payá, M. E."'

1. Methods to evaluate cognitive disorders in animal models | Métodos de evaluación de trastornos cognitivos en modelos animales

Author

Navarrete, F., Pérez-Ortiz, J. M., Femenía, T., García-Gutiérrez, M. S., García-Payá, M. E., Leiva-Santana, C., and Jorge Manzanares

Abstract

Introduction. The increasing prevalence of cognitive dysfunction and dementia associated, among others, to population aging in developed countries has grown a great interest in the study of the etiopathogenesis of cognitive deficit and the likely pharmacological targets which improve intellectual function or alter the neurodegeneration underlying these symptoms. Development and conclusions. An essential tool for that purpose is the use of animal models of human-related pathologies which clinically develop with cognitive impairment and dementia. In this review we will analyse the animal models of these disorders and, specially, the main tests that, by means of the observational evolution of the experimental animal, allow assessing its cognitive functions and its modification by experimental treatments that are wanted to investigate for its eventual introduction into clinics. © 2008, Revista de Neurología.

Published
2008

2. Methods to evaluate cognitive disorders in animal models | Métodos de evaluación de trastornos cognitivos en modelos animales

Author

Navarrete, Francisco, Pérez-Ortiz, José Manuel, Femenía, Teresa, García-Gutiérrez, María Salud, García-Payá, M. E., Leiva-Santana, Carlos, Manzanares, Jorge, Navarrete, Francisco, Pérez-Ortiz, José Manuel, Femenía, Teresa, García-Gutiérrez, María Salud, García-Payá, M. E., Leiva-Santana, Carlos, and Manzanares, Jorge

Abstract

Introduction. The increasing prevalence of cognitive dysfunction and dementia associated, among others, to population aging in developed countries has grown a great interest in the study of the etiopathogenesis of cognitive deficit and the likely pharmacological targets which improve intellectual function or alter the neurodegeneration underlying these symptoms. Development and conclusions. An essential tool for that purpose is the use of animal models of human-related pathologies which clinically develop with cognitive impairment and dementia. In this review we will analyse the animal models of these disorders and, specially, the main tests that, by means of the observational evolution of the experimental animal, allow assessing its cognitive functions and its modification by experimental treatments that are wanted to investigate for its eventual introduction into clinics. © 2008, Revista de Neurología.

Published
2008

5. Laboratory Animals and Neurosciences

Author

Ibañez Alejandra Contreras and Ibañez Alejandra Contreras

Subjects
Nervous system--Diseases--Animal models, Mental illness--Animal models, Laboratory animals, Animal experimentation, Neurosciences
Abstract

Laboratory animals are fundamental in learning and teaching within the various areas of neuroscience research. This from its proper management, animal welfare, standardization of protocols, use of the best biomodel in exprimentation. There are many different areas of study within neurosciences today. However, any use of any biomodel must be based on the context of the three Rs (Refinement, Reduction and Replacement). The objective of this book is to make known through different chapters the use of different laboratory animals in standardized research lines applied to neurosciences in different contexts and applications in basic research.

Published
2020

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