322 results on '"G., SZÁNTÓ"'
Search Results
2. [Trauma: epidemic of our age. 1974]
- Author
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G, Szántó
- Subjects
Europe ,Hungary ,Humans ,Wounds and Injuries ,History, 19th Century ,History, 20th Century - Published
- 2000
3. Late results after repair of partial atrioventricular septal defect in adolescents and adults
- Author
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L, Lukács L, G, Szántó, I, Kassai, and M, Lengyel M
- Subjects
Clinical Investigation - Abstract
From January 1966 through December 1985, 29 adolescents and adults underwent surgical repair of a partial atrioventricular septal defect at our institution. The patients included 20 females and 9 males, whose ages ranged from 16 to 47 years (mean, 27.6 +/- 10.1 years). Preoperatively, 24 patients were in New York Heart Association functional class I or II, and 5 were in class III. The pulmonary artery systolic pressure ranged from 22 to 62 mmHg (mean, 38.3 +/- 12.7 mmHg). The pulmonary-to-systemic flow ratio ranged from 1.4 to 2.9 (mean, 2.3 +/- 0.5). Upon left ventriculography, regurgitation through the left atrioventricular valve was trivial or nonexistent in 4 patients (13.8%), mild in 14 (48.3%), moderate in 10 (34.5%), and severe in 1 patient (3.4%). All patients underwent patch closure of the ostium primum defect, and all but 2 underwent partial or complete suturing of the septal commissure. One patient died within 30 days, for a hospital mortality of 3.4%. The follow-up period ranged from 7 to 25 years (mean, 15.2 +/- 5.3 years). Postoperatively, all patients were evaluated with 2-dimensional and Doppler echocardiography. One patient underwent early implantation of a permanent pacemaker for persistent complete heart block. Three patients succumbed to late death 10, 15, and 21 years after operation. Among the 25 long-term survivors, 1 patient required late valve replacement because of severe left atrioventricular valve regurgitation. Nine (37.5%) of the other 24 long-term survivors had little or no regurgitation. Of the 11 patients with moderate-to-severe preoperative left atrioventricular valve regurgitation, 4 had moderate postoperative regurgitation. Seventeen patients had a moderate or severe persistent apical systolic murmur. At the latest follow-up in 1991, 5 (20%) of the 25 long-term survivors had significant arrhythmias. At 25 years, the actuarial survival rate was 78.9% +/- 25.6%. All 25 surviving patients were in New York Heart Association class I or II. The rate of freedom from reoperation was 77.7% +/- 25.9%. We conclude that, in adolescents and adults, correction of a partial atrioventricular septal defect entails little risk and is likely to improve the patient's functional status. Repair of the left atrioventricular valve yields good results, even at long-term follow-up.
- Published
- 1992
4. Temperature-Induced Route to Chaos in the H2O2−HSO3−−S2O32−Flow Reaction System.
- Author
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Gyula Rábai, Tibor G. Szántó, and Klára Kovács
- Subjects
- *
OSCILLATING chemical reactions , *CHEMICAL reactions , *QUANTUM chaos , *ACTIVATION (Chemistry) , *HYDROGEN-ion concentration , *PHYSICAL & theoretical chemistry - Abstract
Low-frequency, high-amplitude pH-oscillations observed experimentally in the H2O2−HSO3−−S2O32−flow reaction system at 21.0 °C undergo period-doubling cascades to chemical chaos upon decreasing the temperature to 19.0 °C in small steps. Period-4 oscillations are observed at 20.0 °C and can be calculated on the basis of a simple model. A reverse transition from chaos to high-frequency limit cycle oscillations is also observable in the reaction system upon decreasing further the temperature step by step to 15.0 °C. Period-2 oscillations are measured at 18.0 °C. Such a temperature-change-induced transition between periodic and chaotic oscillatory states can be understood by taking into account the different effects of temperature on the rates of composite reactions in the oscillatory system. Small differences in the activation energies of the composite reactions are responsible for the observed transitions. Temperature-change-induced period doubling is suggested as a simple tool for determining whether an experimentally observed random behavior in chemical systems is of deterministic origin or due to experimental noise. [ABSTRACT FROM AUTHOR]
- Published
- 2008
- Full Text
- View/download PDF
5. Vitamin D in Primary Sjogren's Syndrome (pSS) and the Identification of Novel Single-Nucleotide Polymorphisms Involved in the Development of pSS-Associated Diseases.
- Author
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Dabravolski, Siarhei A., Churov, Alexey V., Starodubtseva, Irina A., Beloyartsev, Dmitry F., Kovyanova, Tatiana I., Sukhorukov, Vasily N., and Orekhov, Nikolay A.
- Subjects
NEUROMYELITIS optica ,SJOGREN'S syndrome ,SYMPTOMS ,SINGLE nucleotide polymorphisms ,GENETIC profile ,INTERSTITIAL lung diseases - Abstract
Sjögren's syndrome (SS) is a chronic autoimmune disorder characterised by lymphocytic infiltration of the exocrine glands, which leads to dryness of the eyes and mouth; systemic manifestations such as arthritis, vasculitis, and interstitial lung disease; and increased risks of lymphoma and cardiovascular diseases. SS predominantly affects women, with a strong genetic component linked to sex chromosomes. Genome-wide association studies (GWASs) have identified numerous single-nucleotide polymorphisms (SNPs) associated with primary SS (pSS), revealing insights into its pathogenesis. The adaptive and innate immune systems are crucial to SS's development, with viral infections implicated as environmental triggers that exacerbate autoimmune responses in genetically susceptible individuals. Moreover, recent research has highlighted the role of vitamin D in modulating immune responses in pSS patients, suggesting its potential therapeutic implications. In this review, we focus on the recently identified SNPs in genes like OAS1, NUDT15, LINC00243, TNXB, and THBS1, which have been associated with increased risks of developing more severe symptoms and other diseases such as fatigue, lymphoma, neuromyelitis optica spectrum disorder (NMOSD), dry eye syndrome (DES), and adverse drug reactions. Future studies should focus on larger, multi-ethnic cohorts with standardised protocols to validate findings and identify new associations. Integrating genetic testing into clinical practise holds promise for improving SS management and treatment strategies, enabling personalised interventions based on comprehensive genetic profiles. By focusing on specific SNPs, vitamin D, and their implications, future research can lead to more effective and personalised approaches for managing pSS and its complications. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
6. Subpopulation dynamics of T and B lymphocytes in Sjögren's syndrome: implications for disease activity and treatment.
- Author
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Qingliang Meng, Junfu Ma, Jiakang Cui, Yangyi Gu, and Yu Shan
- Subjects
T helper cells ,SJOGREN'S syndrome ,B cells ,T cells ,EPITHELIAL cells - Abstract
Sjögren's syndrome (SS) is an autoimmune disorder primarily affecting the body's exocrine glands, particularly the salivary and lacrimal glands, which lead to severe symptoms of dry eyes and mouth. The pathogenesis of SS involves the production of autoantibodies by activated immune cells, and secretion of multiple cytokines, which collectively lead to tissue damage and functional impairment. In SS, the Immune interaction among T and B cells is particularly significant. Lymphocytic infiltration in the salivary glands is predominantly composed of CD4+ T cells, whose activation cause the death of glandular epithelial cells and subsequent tissue destruction. The excessive activity of T cells contributes significantly to the disease mechanism, with helper T cells (CD4 +) differentiating into various subgroups including Th1/Th2, Th17, as well as Treg, each contributing to the pathological process through distinct cytokine secretion. In patients with SS, B cells are excessively activated, leading to substantial production of autoantibodies. These antibodies can attack selftissues, especially the lacrimal and salivary glands, causing inflammation and tissue damage. Changes in B cell subpopulations in SS patients, such as increases in plasmablasts and plasma cells, correlate positively with serum autoantibody levels and disease progression. Therapies targeting T cells and B cells are extensively researched with the aim of alleviating symptoms and improving the quality of life for patients. Understanding how these cells promote disease development through various mechanisms, and further identifying novel T and B cell subgroups with functional characterization, will facilitate the development of more effective strategies to treat SS. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
7. Retransfusion acidosis after haemorrhagic hypotension in dogs
- Author
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G. Szántó, E. Vándor, and L. Takács
- Subjects
Male ,Partial Pressure ,Bicarbonate ,Potassium ,Plasma Substitutes ,chemistry.chemical_element ,Blood Pressure ,Hemorrhage ,Hepatic Veins ,Low molecular weight dextran ,chemistry.chemical_compound ,Dogs ,Animals ,Medicine ,Blood Transfusion ,Pyruvates ,General Environmental Science ,Acidosis ,Acid-Base Equilibrium ,Blood Volume ,Portal Vein ,business.industry ,Shed blood ,Dextrans ,Carbon Dioxide ,Femoral Vein ,Hydrogen-Ion Concentration ,Oxygen ,Bicarbonates ,Blood ,Dextran ,chemistry ,Anesthesia ,Lactates ,General Earth and Planetary Sciences ,Female ,Hypotension ,medicine.symptom ,business - Abstract
Summary Anaesthetized dogs subjected to severe haemorrhagic hypotension followed by spontaneous uptake of 30 per cent of the shed blood were studied. One group was then transfused with blood, another with low molecular weight dextran, and a third with Locke's solution. During the hypotensive phase, the arterial p H, standard bicarbonate, buffer base and Pco 2 fell, while the lactate, pyruvate, and potassium values rose. Within half a minute of retransfusion, the p H decreased further but the Pco 2 rose to normal or higher values. The greatest fall in p H occurred in the dextran group, but the p H of dextran is lower than that of the reinfused blood or Locke's solution. The fall in p H and rise in Pco 2 after retransfusion occur with unchanged lactate levels and so cannot be attributed to ‘washout’ of lactate from the tissues.
- Published
- 1974
8. Untersuchungen Über den Nitritgehalt des Speichels, des Magensaftes und des Harnes
- Author
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J. Várady and G. Szántó
- Subjects
Gynecology ,medicine.medical_specialty ,business.industry ,Drug Discovery ,Molecular Medicine ,Medicine ,General Medicine ,business ,Genetics (clinical) - Abstract
1. Bei Entzundungen und malignen Tumoren ist die Nitritausscheidung im Speichel erhoht, das 3–5fache der Norm. 2. Im Speichel unbehandelter Hypertoniekranker ist Nitrit nicht nachweisbar. 3. Im Speichel von Hypertoniekranken, die mit nitrithaltigen Mitteln behandelt wurden, ist eine starke Nitritausscheidung vorhanden. 4. Die Menge und der Nitritgehalt des nach 0,01 Pilocarpin ausgeschiedenen Speichels stehen im umgekehrten Verhaltnis zueinander. 5. Im vom Speichel getrennt entnommenen Magensaft ist Nitrit nicht nachweisbar. 6. Nitritausscheidung durch die Nieren kommt bei verschiedenen schwereren Erkrankungen, in erster Linie bei Tumoren, vor.
- Published
- 1940
9. Über gegen Spermien gebildeten Antikörper
- Author
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G. Szántó and Z. Aszódi
- Subjects
Gynecology ,medicine.medical_specialty ,business.industry ,medicine ,General Medicine ,business - Abstract
1. Gegen resorbierte Spermien werden Antikorper gebildet. 2. Der Antikorper ist bei Frauen haufiger vorzufinden als bei Mannern. 3. Bei Madchen, die noch kein Geschlechtsleben gefuhrt haben (Virgo) und bei Knaben, die das Pubertatsalter noch nicht erreicht haben, ist der Antikorper nicht nachweisbar.
- Published
- 1936
10. Exploring the Role of PD-1 in the Autoimmune Response: Insights into Its Implication in Systemic Lupus Erythematosus.
- Author
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Sagrero-Fabela, Nefertari, Chávez-Mireles, Ramón, Salazar-Camarena, Diana Celeste, and Palafox-Sánchez, Claudia Azucena
- Subjects
SYSTEMIC lupus erythematosus ,PROGRAMMED cell death 1 receptors ,T cells ,AUTOIMMUNE diseases ,LIGANDS (Biochemistry) - Abstract
Despite advances in understanding systemic lupus erythematosus (SLE), many challenges remain in unraveling the precise mechanisms behind the disease's development and progression. Recent evidence has questioned the role of programmed cell death protein 1 (PD-1) in suppressing autoreactive CD4
+ T cells during autoimmune responses. Research has investigated the potential impacts of PD-1 on various CD4+ T-cell subpopulations, including T follicular helper (Tfh) cells, circulating Tfh (cTfh) cells, and T peripheral helper (Tph) cells, all of which exhibit substantial PD-1 expression and are closely related to several autoimmune disorders, including SLE. This review highlights the complex role of PD-1 in autoimmunity and emphasizes the imperative for further research to elucidate its functions during autoreactive T-cell responses. Additionally, we address the potential of PD-1 and its ligands as possible therapeutic targets in SLE. [ABSTRACT FROM AUTHOR]- Published
- 2024
- Full Text
- View/download PDF
11. Vitamin D and Muscle Status in Inflammatory and Autoimmune Rheumatic Diseases: An Update.
- Author
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Hysa, Elvis, Gotelli, Emanuele, Campitiello, Rosanna, Paolino, Sabrina, Pizzorni, Carmen, Casabella, Andrea, Sulli, Alberto, Smith, Vanessa, and Cutolo, Maurizio
- Abstract
Background and Objectives: Vitamin D is a secosteroid hormone essential for calcium homeostasis and skeletal health, but established evidence highlights its significant roles also in muscle health and in the modulation of immune response. This review aims to explore the impact of impaired vitamin D status on outcomes of muscle function and involvement in inflammatory and autoimmune rheumatic diseases damaging the skeletal muscle efficiency both with direct immune-mediated mechanisms and indirect processes such as sarcopenia. Methods: A comprehensive literature search was conducted on PubMed and Medline using Medical Subject Headings (MeSH) terms: "vitamin D, muscle, rheumatic diseases." Additionally, conference abstracts from The European Alliance of Associations for Rheumatology (EULAR) and the American College of Rheumatology (ACR) (2020–2023) were reviewed, and reference lists of included papers were scanned. The review emphasizes the evidence published in the last five years, while also incorporating significant studies from earlier years, structured by the extent of evidence linking vitamin D to muscle health in the most commonly inflammatory and autoimmune rheumatic diseases encountered in clinical practice. Results: Observational studies indicate a high prevalence of vitamin D serum deficiency (mean serum concentrations < 10 ng/mL) or insufficiency (<30 ng/mL) in patients with idiopathic inflammatory myopathies (IIMs) and polymyalgia rheumatica, as well as other autoimmune connective tissue diseases such as rheumatoid arthritis (RA), systemic lupus erythematosus (SLE) and systemic sclerosis (SSc). Of note, vitamin D insufficiency may be associated with reduced muscle strength (2 studies on RA, 2 in SLE and 1 in SSc), increased pain (1 study on SLE), fatigue (2 studies on SLE), and higher disease activity (3 studies on IIMs and 1 on SLE) although there is much heterogeneity in the quality of evidence and different associations for the different investigated diseases. Therefore, linked to the multilevel biological intervention exerted by vitamin D, several translational and clinical studies suggest that active metabolites of this secosteroid hormone, play a role both in reducing inflammation, but also in enhancing muscle regeneration, intra-cellular metabolism and mitochondrial function, although interventional studies are limited. Conclusions: Altered serum vitamin D status is commonly observed in inflammatory and autoimmune rheumatic diseases and seems to be associated with adverse muscle health outcomes. While maintaining adequate serum vitamin D concentrations may confer muscle-protective effects, further research is needed to confirm these findings and establish optimal supplementation strategies to obtain a safe and efficient serum threshold. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
12. Numerical simulations of the optical properties of SiO2@Au core–shell nanoparticles: The effect of geometrical parameters on the tunability and sensitivity of their plasmon response.
- Author
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Al-Qadi, Bassam
- Subjects
OPTICAL properties ,COMPUTER simulation ,NANOPARTICLES - Abstract
Based on systematic numerical simulations, the effect of geometrical parameters of SiO
2 @Au core-shells (nanoshells) on the tunability and sensitivity of their optical response was elucidated. The surface plasmon resonance (SPR) of nanoshells experiences a blueshift-redshift crossover with the increase in shell thickness, and this phenomenon is ascribed to the competition between the two effects, that is, the hybridization effect dominated in the thin shells and the retardation effect dominated in the thick shells. The relative strength of absorption/scattering in the extinction spectra and the relative strength of dipolar/multipolar modes can be selectively tuned by controlling the total volume of nanoshells. The sensitivity of the SPR peak wavelength to the shell thickness is primarily dependent on the core-to-shell ratio; the higher this ratio is, the larger the sensitivity. The tailorable properties of nanoshells make them promising and well-suited platforms in various applications. [ABSTRACT FROM AUTHOR]- Published
- 2024
- Full Text
- View/download PDF
13. [Trauma: epidemic of our age. 1974].
- Author
-
Szántó G
- Subjects
- Europe epidemiology, History, 19th Century, History, 20th Century, Humans, Hungary epidemiology, Wounds and Injuries epidemiology, Wounds and Injuries history
- Published
- 1999
14. [Accidents, epidemic of our age]
- Author
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G, Szántó
- Subjects
Adult ,Male ,Hungary ,Accident Prevention ,Adolescent ,Accidents ,Accidents, Traffic ,Humans ,Wounds and Injuries ,Female ,Middle Aged - Published
- 1974
15. Retransfusion acidosis after brief haemorrhagic hypotension in the dog
- Author
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L, Takács, G, Szántó, and E, Vándor
- Subjects
Male ,Oxygen ,Blood Transfusion, Autologous ,Dogs ,Lactates ,Animals ,Blood Pressure ,Female ,Hemorrhage ,Carbon Dioxide ,Hydrogen-Ion Concentration ,Hypotension ,Acidosis - Abstract
Dogs under chloralose anasthesia were bled at a rate of 50 ml/min to a total of 25 ml/kg body weight and 2 minutes later a quick reinfusion of adequate volumes of blood, dextran, or Locke's solution was done. Within 2 minutes after reinfusion, the pH of arterial blood fell by 0.074--0.127; concurrently, PaCO2 rose by 9.2-12.9 mm Hg. A close correlation was demonstrated between these changes. After retransfusion, PaO2 and the arterial lactic acid level did not change significantly. Thus retransfusion acidosis in the dog appears after a brief hypotensive period, too, but cannot be attributed to a "washout" of lactate from the tissues.
- Published
- 1976
16. [Surgical correction of ostium primum persistens: late results]
- Author
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G, Szántó, M, Erdélyi, K, Sárközy, and A, Arvay
- Subjects
Adult ,Male ,Postoperative Complications ,Adolescent ,Child, Preschool ,Humans ,Mitral Valve Insufficiency ,Arrhythmias, Cardiac ,Female ,Child ,Heart Septal Defects, Atrial ,Follow-Up Studies - Published
- 1978
17. [Dr. György Szántó (1907-1982)]
- Author
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G, Szántó
- Subjects
Hungary ,General Surgery ,History, 20th Century ,Military Medicine - Published
- 1982
18. [Prof. György Szántó 70 years old]
- Author
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G, Szántó
- Subjects
Hungary ,General Surgery ,History, 20th Century ,Military Medicine - Published
- 1977
19. [Prof. György Szántó, 1907-1982]
- Author
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G, Szántó
- Subjects
Hungary ,General Surgery ,History, 20th Century ,Military Medicine - Published
- 1982
20. Retransfusion acidosis and ventilation
- Author
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L, Takács, G, Szántó, and E, Vándor
- Subjects
Male ,Dogs ,Lactates ,Animals ,Transfusion Reaction ,Blood Pressure ,Female ,Carbon Dioxide ,Hydrogen-Ion Concentration ,Shock, Hemorrhagic ,Acidosis ,Respiration, Artificial - Abstract
The blood pressure of dogs anaesthetized with 0.1 g/kg of chloralose was reduced to 40 mm Hg by arterial bleeding. Thirty percent of the drawn blood refluxed spontaneously, the rest was retransfused either suddenly arterially or slowly in 15 minutes by the venous route. In other groups a total quantity of 25 ml/kg was drawn from an artery at a rate of 50 ml/kg and after about one minute the entire quantity of blood was rapidly retransfused through the artery. The control group breathed spontaneously, the other groups were given artificial respiration, or the sinus nerves and the vagus were transected separately or simultaneously, or transection was combined with artificial ventilation.
- Published
- 1980
21. [Various biological factors in wound healing]
- Author
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G, Szántó
- Subjects
Wound Healing ,Guinea Pigs ,Cyprinidae ,Fishes ,DNA ,Body Temperature ,Rats ,Dogs ,Oxygen Consumption ,Connective Tissue ,Animals ,RNA ,Glycolysis ,Skin - Published
- 1967
22. [Intensive patient care at the National Institute for Traumatology in Budapest]
- Author
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P, Varga, O, Székely, G, Szántó, Z, Btage, A, Takáts, and J, Heid
- Subjects
Hungary ,Accidents ,Resuscitation ,First Aid ,Humans ,Wounds and Injuries ,Emergency Service, Hospital ,Hospitals, Special - Published
- 1971
23. Effect of procain blockade applied at different times following temporary occlusion of the renal artery
- Author
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G, Szántó, L, Takács, and R, Jankovics
- Subjects
Dogs ,Kidney Tubules ,Time Factors ,Animals ,Acute Kidney Injury ,Renal Artery Obstruction ,Procaine - Published
- 1968
24. [Prosthetic osteologic studies of the border area between palate and velum]
- Author
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G, Szántó
- Subjects
Palate ,Denture, Complete, Upper ,Humans ,Pharynx ,Denture Retention - Published
- 1969
25. The effect of blood loss on renal function after temporary occlusion of the renal artery in the dog
- Author
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G, Szántó, L, Takács, and R, Jankovics
- Subjects
Male ,Dogs ,Time Factors ,Creatinine ,Animals ,Female ,Hemorrhage ,Acute Kidney Injury ,Kidney ,Renal Artery Obstruction ,Blood Urea Nitrogen - Published
- 1970
26. Accident services in Hungary
- Author
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G. Szántó
- Subjects
Injury control ,Accident prevention ,Ambulances ,Poison control ,Suicide prevention ,Occupational safety and health ,Injury prevention ,Medicine ,Humans ,Hospitals, Teaching ,Accident (philosophy) ,Referral and Consultation ,General Environmental Science ,Hungary ,business.industry ,Human factors and ergonomics ,medicine.disease ,Transportation of Patients ,Education, Medical, Graduate ,Organization and Administration ,Accidents ,Workforce ,General Earth and Planetary Sciences ,Wounds and Injuries ,Medical emergency ,business ,Emergency Service, Hospital - Published
- 1972
27. Effect of procaine on the vessels of the ischaemic kidney in the dog
- Author
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L, Takács, L, Józsa, and G, Szántó
- Subjects
Solutions ,Dogs ,Renal Artery ,Chlorides ,Ischemia ,Animals ,Polyvinyls ,Kidney ,Ligation ,Procaine - Published
- 1972
28. Investigating the effect of grit trait on performance and success in Hungarian athlete's sample.
- Author
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Apró, Annamária, Fejes, Nikoletta, Bandi, Szabolcs A., and Járai, Róbert
- Subjects
COACH-athlete relationships ,CONFIRMATORY factor analysis ,ATHLETES ,SPORTS psychology - Abstract
Background: The aim of the present study is to translate the Grit questionnaire into Hungarian and validate specifically within the context of sports. The second goal is to assess the questionnaire in Hungarian as a pilot study in the athlete population and to compare the grit trait with the coaches' athlete evaluation. Methods: Two hundred and sixty nine athletes, including 40 national team players, took part in the study, with an average age of 18.17 years (SD = 5.51). For the preliminary assessment, the Cloninger Temperament and Character Questionnaire (TCI-RH) was used; the coaches' athlete evaluation was modeled on a talent map. Results: The confirmatory factor analysis confirmed the fit of the two-factor structure, and the internal reliability of the questionnaire scales also proved to be adequate. 2. There is no relationship between adolescents' perceived grit and coach ratings. 3. The national team players achieved a higher grit score. Conclusion: Based on the psychometric indicators, the validity and reliability of the questionnaire proved to be adequate. Therefore, it is applicable and useful for psychological practitioners and researchers in the Hungarian population within the context of sports. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
29. Tankyrase-1 regulates RBP-mediated mRNA turnover to promote muscle fiber formation.
- Author
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Mubaid, Souad, Sanchez, Brenda Janice, Algehani, Rinad A, Skopenkova, Viktoriia, Adjibade, Pauline, Hall, Derek T, Busque, Sandrine, Lian, Xian Jin, Ashour, Kholoud, Tremblay, Anne-Marie K, Carlile, Graeme, Gagné, Jean-Philippe, Diaz-Gaxiola, Andrea, Khattak, Shahryar, Di Marco, Sergio, Thomas, David Y, Poirier, Guy G, and Gallouzi, Imed-Eddine
- Published
- 2024
- Full Text
- View/download PDF
30. Non-Invasive Assessment of Micro- and Macrovascular Function after Initiation of JAK Inhibitors in Patients with Rheumatoid Arthritis.
- Author
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Anyfanti, Panagiota, Angeloudi, Elena, Dara, Athanasia, Pagkopoulou, Eleni, Moysidou, Georgia-Savina, Deuteraiou, Kleopatra, Boutel, Maria, Bekiari, Eleni, Doumas, Michael, Kitas, George D., and Dimitroulas, Theodoros
- Subjects
CAROTID intima-media thickness ,RHEUMATOID arthritis ,AMBULATORY blood pressure monitoring ,PULSE wave analysis ,ARTERIAL diseases ,ANTIRHEUMATIC agents ,ABATACEPT - Abstract
Background: Janus kinase (JAK) inhibitors constitute a novel class of oral biologic disease-modifying antirheumatic drugs for patients with rheumatoid arthritis (RA). However, their use has been associated with increased risk of major cardiovascular events. We investigated whether treatment with JAK inhibitors exerts significant alterations in the micro- and microvasculature in RA patients. Methods: Thirteen patients with RA initiating treatment with JAK inhibitors were prospectively studied. Eventually, data from 11 patients who completed the study were analyzed. Procedures were performed at baseline and 3 months after treatment. Nailfold videocapillaroscopy was applied to detect alterations of the dermal capillary network. Participants underwent 24 h ambulatory blood pressure monitoring (Mobil-O-Graph device) for the assessment of blood pressure (both brachial and aortic) and markers of large artery stiffening [pulse wave velocity (PWV), augmentation index] throughout the whole 24 h and the respective day- and nighttime periods. Carotid intima–media thickness was assessed with ultrasound. Results: Three-month treatment with JAK inhibitors was not associated with any differences in brachial and aortic blood pressure, arterial stiffness, and carotid atherosclerosis, with the only exception of nighttime PWV, which was significantly elevated at follow-up. However, three-month treatment with JAK inhibitors induced significant microvascular alterations and increased the total number of capillaroscopic abnormalities. Conclusions: Three-month treatment with JAK inhibitors may exert significant effects on microcirculation as assessed with nailfold videocapillaroscopy, whereas macrovascular structure and function appears largely unaffected. Further research toward this direction may add substantial information to the available literature regarding cardiovascular aspects of JAK inhibitors in RA. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
31. Assessment of a novel electrochemically deposited smart bioactive trabecular coating (SBTC®): a randomized controlled clinical trial.
- Author
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Antal, Mark Adam, Kiscsatári, Ramóna, Braunitzer, Gábor, Piffkó, József, Varga, Endre, and Eliaz, Noam
- Subjects
CLINICAL trials ,RANDOMIZED controlled trials ,PHOSPHATE coating ,SURFACE preparation ,IMMEDIATE loading (Dentistry) ,SURFACE coatings ,OVERLAY dentures - Abstract
Objectives: A randomized controlled clinical trial of dental implants was conducted to compare the clinical properties of a novel electrochemically deposited calcium phosphate coating to those of a common marketed surface treatment. Material and methods: Forty implants of the same brand and type were placed in 20 fully edentulous participants requiring mandibular implantation. The two study groups were defined by the surface treatment of the implants. 20 implants in the control group were coated via a commercial electrochemical surface treatment that forms a mixture of brushite and hydroxyapatite, while the remaining 20 in the test group were coated with a novel electrochemical Smart Bioactive Trabecular Coating (SBTC®). A split-mouth design was employed, with each participants receiving one control implant in one mandibular side and a test implant in the other. To mitigate potential operator-handedness bias, control and test implants were randomly assigned to mandibular sides. All cases underwent digital planning, implant placement with a static surgical guide, and participants received locator-anchored full-arch dentures. The primary outcome was implant stability (measured using Osstell ISQ) assessed at insertion, loading, and then 3 months, 9 months, and 2 years post-insertion. The secondary outcome was bone level change (in millimeters) over the 2-year observation period. Oral health-related quality of life (OHRQL) was monitored using the OHIP-14 questionnaire. Complications and adverse events were recorded. Results: Successful osseointegration and implant stability were achieved in all cases, allowing loading. ISQ values steadily increased throughout the observation period. While no significant differences were observed between the SBTC® and control coatings, the test group exhibited a higher ISQ gain. Bone resorption was somewhat lower in the SBTC® but not significantly so. Patients' OHRQL significantly improved after denture delivery and remained stable throughout the follow-up. No complications or adverse events were observed. Conclusions: Based on the study results, we conclude that the new surface treatment is a safe alternative to the widely used control surface, demonstrating similar osseointegrative properties and time-dependent bone level changes. Further research may explore the broader implications of these findings. Trial registration: The study is registered on clinicaltrials.gov under the identifier ID: NCT06034171. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
32. Comparison of the Capacity of Several Machine Learning Tools to Assist Immunofluorescence-Based Detection of Anti-Neutrophil Cytoplasmic Antibodies.
- Author
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Bertin, Daniel, Bongrand, Pierre, and Bardin, Nathalie
- Subjects
ANTINEUTROPHIL cytoplasmic antibodies ,MACHINE learning ,ARTIFICIAL intelligence ,CARRAGEENANS ,K-nearest neighbor classification ,NEUTROPHILS ,CELL imaging - Abstract
The success of artificial intelligence and machine learning is an incentive to develop new algorithms to increase the rapidity and reliability of medical diagnosis. Here we compared different strategies aimed at processing microscope images used to detect anti-neutrophil cytoplasmic antibodies, an important vasculitis marker: (i) basic classifier methods (logistic regression, k-nearest neighbors and decision tree) were used to process custom-made indices derived from immunofluorescence images yielded by 137 sera. (ii) These methods were combined with dimensional reduction to analyze 1733 individual cell images. (iii) More complex models based on neural networks were used to analyze the same dataset. The efficiency of discriminating between positive and negative samples and different fluorescence patterns was quantified with Rand-type accuracy index, kappa index and ROC curve. It is concluded that basic models trained on a limited dataset allowed for positive/negative discrimination with an efficiency comparable to that obtained by conventional analysis performed by humans (0.84 kappa score). More extensive datasets and more sophisticated models may be required for efficient discrimination between fluorescence patterns generated by different auto-antibody species. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
33. Identification of social scientifically relevant topics in an interview repository: a natural language processing experiment.
- Author
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Gárdos, Judit, Egyed-Gergely, Julia, Horváth, Anna, Pataki, Balázs, Vajda, Roza, and Micsik, András
- Subjects
NATURAL language processing ,DATA libraries ,SCIENTIFIC computing ,TAXONOMY ,ARTIFICIAL intelligence ,INDEXING ,FOLKSONOMIES - Abstract
Purpose: The present study is about generating metadata to enhance thematic transparency and facilitate research on interview collections at the Research Documentation Centre, Centre for Social Sciences (TK KDK) in Budapest. It explores the use of artificial intelligence (AI) in producing, managing and processing social science data and its potential to generate useful metadata to describe the contents of such archives on a large scale. Design/methodology/approach: The authors combined manual and automated/semi-automated methods of metadata development and curation. The authors developed a suitable domain-oriented taxonomy to classify a large text corpus of semi-structured interviews. To this end, the authors adapted the European Language Social Science Thesaurus (ELSST) to produce a concise, hierarchical structure of topics relevant in social sciences. The authors identified and tested the most promising natural language processing (NLP) tools supporting the Hungarian language. The results of manual and machine coding will be presented in a user interface. Findings: The study describes how an international social scientific taxonomy can be adapted to a specific local setting and tailored to be used by automated NLP tools. The authors show the potential and limitations of existing and new NLP methods for thematic assignment. The current possibilities of multi-label classification in social scientific metadata assignment are discussed, i.e. the problem of automated selection of relevant labels from a large pool. Originality/value: Interview materials have not yet been used for building manually annotated training datasets for automated indexing of scientifically relevant topics in a data repository. Comparing various automated-indexing methods, this study shows a possible implementation of a researcher tool supporting custom visualizations and the faceted search of interview collections. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
34. The Role of Transglutaminase 2 in Cancer: An Update.
- Author
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Zaltron, Elisabetta, Vianello, Federica, Ruzza, Alessia, Palazzo, Alberta, Brillo, Valentina, Celotti, Ilaria, Scavezzon, Matteo, Rossin, Federica, Leanza, Luigi, and Severin, Filippo
- Subjects
ENZYME regulation ,PEPTIDES ,PROTEIN kinases ,EUKARYOTIC cells ,ISOMERASES ,LUNG cancer ,TISSUE remodeling ,POST-translational modification - Abstract
Transglutaminase type 2 (TG2) is the most ubiquitously expressed and well characterized member of the transglutaminase family. It is a ubiquitous multifunctional enzyme implicated in the regulation of several cellular pathways that support the survival, death, and general homeostasis of eukaryotic cells. Due to its multiple localizations both inside and outside the cell, TG2 participates in the regulation of many crucial intracellular signaling cascades in a tissue- and cell-specific manner, making this enzyme an important player in disease development and progression. Moreover, TG2 is capable of modulating the tumor microenvironment, a process of dynamic tissue remodeling and biomechanical events, resulting in changes which influence tumor initiation, growth, and metastasis. Even if generally related to the Ca
2+ -dependent post-translational modification of proteins, a number of different biological functions have been ascribed to TG2, like those of a peptide isomerase, protein kinase, guanine nucleotide binder, and cytosolic–nuclear translocator. With respect to cancer, TG2′s role is controversial and highly debated; it has been described both as an anti- and pro-apoptotic factor and is linked to all the processes of tumorigenesis. However, numerous pieces of evidence support a tissue-specific role of TG2 so that it can assume both oncogenic and tumor-suppressive roles. [ABSTRACT FROM AUTHOR]- Published
- 2024
- Full Text
- View/download PDF
35. Matrix- and Surface-Assisted Laser Desorption/Ionization Mass Spectrometry Methods for Urological Cancer Biomarker Discovery—Metabolomics and Lipidomics Approaches.
- Author
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Arendowski, Adrian
- Subjects
MASS spectrometry ,LIPIDOMICS ,MATRIX-assisted laser desorption-ionization ,DESORPTION ,DESORPTION ionization mass spectrometry ,METABOLOMICS ,BIOMARKERS - Abstract
Urinary tract cancers, including those of the bladder, the kidneys, and the prostate, represent over 12% of all cancers, with significant global incidence and mortality rates. The continuous challenge that these cancers present necessitates the development of innovative diagnostic and prognostic methods, such as identifying specific biomarkers indicative of cancer. Biomarkers, which can be genes, proteins, metabolites, or lipids, are vital for various clinical purposes including early detection and prognosis. Mass spectrometry (MS), particularly soft ionization techniques such as electrospray ionization (ESI) and laser desorption/ionization (LDI), has emerged as a key tool in metabolic profiling for biomarker discovery, due to its high resolution, sensitivity, and ability to analyze complex biological samples. Among the LDI techniques, matrix-assisted laser desorption/ionization (MALDI) and surface-assisted laser desorption/ionization (SALDI) should be mentioned. While MALDI methodology, which uses organic compounds as matrices, is effective for larger molecules, SALDI, based on the various types of nanoparticles and nanostructures, is preferred for smaller metabolites and lipids due to its reduced spectral interference. This study highlights the application of LDI techniques, along with mass spectrometry imaging (MSI), in identifying potential metabolic and lipid biomarkers for urological cancers, focusing on the most common bladder, kidney, and prostate cancers. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
36. MOBILE EXPLORING OF BULGARIAN CULTURAL AND SCIENTIFIC ASSETS.
- Author
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Márkus, Zsolt László, Kaposi, Gábor, Szántó, György, Szkaliczki, Tibor, Veres, Miklós, Weisz, Zsolt, Luchev, Detelin, Paneva-Marinova, Desislava, Pavlov, Radoslav, and Pavlova, Lilia
- Subjects
CULTURAL maintenance ,DIGITAL libraries ,MOBILE apps ,CULTURE ,DIGITAL preservation ,CULTURAL property - Abstract
The paper introduces an ecosystem of digital libraries and mobile applications for presenting Bulgarian cultural and science assets. The digital libraries concerned constitute valuable sources of cultural heritage and related scientific results. They include the Bulgarian Iconographical Digital Library (BIDL), the BellKnow multimedia archive on bells and the web site of the International Conference on Digital Presentation and Preservation of Cultural and Scientific Heritage (DIPP). These digital libraries can be accessed online through a Web interface. Due to the spread of mobile devices, there is a need to present the contents through mobile platforms as well. The GUIDE@HAND application family was integrated with the digital libraries for presenting the cultural and scientific assets offline in mobile applications. Interactive multimedia components (e. g., games, panorama pictures, maps etc.) make the presentation more attractive. The developed mobile applications facilitate learning, presentation and preservation of cultural and scientific objects. [ABSTRACT FROM AUTHOR]
- Published
- 2016
37. Über Zusammenhang mit Hodenantigen angestellter Komplementbindungsreaktion und Geschlecht des Fetus
- Author
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G. Szántó
- Subjects
Gynecology ,medicine.medical_specialty ,business.industry ,Medicine ,General Medicine ,business - Published
- 1938
38. Oroxylin A attenuates psoriasiform skin inflammation by direct targeting p62 (sequestosome 1) via suppressing M1 macrophage polarization.
- Author
-
Ma Y, Liu Y, Zhong Y, Li X, Xu Y, Chen L, Gong L, Huang H, Chen X, He Y, and Qiang L
- Abstract
Background and Purpose: Psoriasis results from the interplay of innate and adaptive immunity in the skin. Oroxylin A (OA) has shown anti-inflammatory effects in various disorders. This study explores oroxylin A potential in treating psoriasis, particularly its impact on type I macrophage (Mφ1) polarization., Experimental Approach: Oroxylin A-mediated therapeutic effects were evaluated using imiquimod-induced or IL-23-injected psoriatic mice models, followed by proteomics assays to predict potential signalling and targeting proteins. Immunofluorescence and immunoblot assays verified that oroxylin A suppresses NF-kB signalling in M1 macrophages. Co-immunoprecipitation and microscale thermophoresis (MST) assays further demonstrated that p62 (sequestosome 1) is the target protein for oroxylin A in macrophages. Oroxylin A-p62-mediated suppression of psoriasis was validated in an imiquimod-induced p62 conditional knockout (cKO) mice model., Key Results: Oroxylin A demonstrated therapeutic efficacy in murine models induced by imiquimod or IL-23 by attenuating cutaneous inflammation and mitigating Mφ1 polarization via NF-κB signalling. Proteomics analysis suggested SQSTM1/p62 as a key target, confirmed to interact directly with oroxylin A. Oroxylin A disrupted the p62-PKCζ interaction by binding to PB1 domain of p62. Its anti-inflammatory effects were significantly reduced in macrophages from p62 cKO mice compared to the wild-type (WT) mice in psoriasis model, supporting oroxylin A role in suppressing Mφ1 polarization through its interaction with p62., Conclusion and Implications: Our findings demonstrated oroxylin A suppressed psoriasiform skin inflammation in mouse models by blocking the PKCζ-p62 interaction, subsequently inhibiting the activation of NF-κB p65 phosphorylation in macrophages., (© 2024 British Pharmacological Society.)
- Published
- 2024
- Full Text
- View/download PDF
39. Modelling of nanosensors based on localised surface plasmon resonance.
- Author
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Firoozi, Aida, Khordad, Reza, and Rastegar Sedehi, Hamid Reza
- Subjects
SURFACE plasmon resonance ,NANOSENSORS ,BOUNDARY element methods ,NANOPARTICLE size ,METAL nanoparticles ,REFRACTIVE index - Abstract
To design nanosensors based on localised surface plasmon (LSP), a structure is considered consisting of metal nanoparticles and study the influence of nanoparticles size, material, geometry, and background refractive index (RI) on its performance. We propose a nanosensor based on nanoplasmonic and investigate its sensitivity. The boundary element method is employed to calculate the extinction cross-section and sensitivity of the proposed sensor. We study the effect of various parameters on LSP resonance. Our calculations about extinction, scattering, and absorption spectra have been compared with experimental data. According to the comparison, it is deduced the boundary element method provides acceptable results. It is shown that the proposed nanosensor is very sensitive to the variation of sample RI. Moreover, it is possible to adjust the required spectral range by changing the geometry and material of nanoparticles. Here, the highest sensitivity is obtained for cubic nanoparticles made of silver. [ABSTRACT FROM AUTHOR]
- Published
- 2023
- Full Text
- View/download PDF
40. Chemotherapeutic drugs for soft tissue sarcomas: a review.
- Author
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Zhichao Tian and Weitao Yao
- Subjects
SARCOMA ,CANCER chemotherapy ,DRUG therapy ,PEMETREXED ,IFOSFAMIDE ,EWING'S sarcoma ,DRUGS ,CARBOPLATIN - Abstract
Despite the low incidence of soft tissue sarcomas (STSs), hundreds of thousands of new STS cases are diagnosed annually worldwide, and approximately half of them eventually progress to advanced stages. Currently, chemotherapy is the first-line treatment for advanced STSs. There are difficulties in selecting appropriate drugs for multiline chemotherapy, or for combination treatment of different STS histological subtypes. In this study, we first comprehensively reviewed the efficacy of various chemotherapeutic drugs in the treatment of STSs, and then described the current status of sensitive drugs for different STS subtypes. anthracyclines are the most important systemic treatment for advanced STSs. Ifosfamide, trabectedin, gemcitabine, taxanes, dacarbazine, and eribulin exhibit certain activities in STSs. Vinca alkaloid agents (vindesine, vinblastine, vinorelbine, vincristine) have important therapeutic effects in specific STS subtypes, such as rhabdomyosarcoma and Ewing sarcoma family tumors, whereas their activity in other subtypes is weak. Other chemotherapeutic drugs (methotrexate, cisplatin, etoposide, pemetrexed) have weak efficacy in STSs and are rarely used. It is necessary to select specific second- or above-line chemotherapeutic drugs depending on the histological subtype. This review aims to provide a reference for the selection of chemotherapeutic drugs for multi-line therapy for patients with advanced STSs who have an increasingly long survival. [ABSTRACT FROM AUTHOR]
- Published
- 2023
- Full Text
- View/download PDF
41. E-Selectin, ICAM-1, and ET-1 Biomarkers Address the Concern of the Challenging Diagnosis of Interstitial Lung Disease in Patients with Autoimmune Diseases.
- Author
-
Pulito-Cueto, Verónica, Remuzgo-Martínez, Sara, Genre, Fernanda, Atienza-Mateo, Belén, Mora-Cuesta, Víctor M., Iturbe-Fernández, David, Lera-Gómez, Leticia, Mora-Gil, María Sebastián, Portilla, Virginia, Corrales, Alfonso, Blanco, Ricardo, Cifrián, José M., González-Gay, Miguel A., and López-Mejías, Raquel
- Subjects
INTERSTITIAL lung diseases ,AUTOIMMUNE diseases ,LUNGS ,IDIOPATHIC pulmonary fibrosis ,SYSTEMIC scleroderma ,BLOOD proteins - Abstract
Interstitial lung disease (ILD) constitutes the most critical comorbidity in autoimmune diseases (ADs) and its early diagnosis remains a challenge for clinicians. Accordingly, we evaluated whether E-selectin, ICAM-1, and ET-1, key molecules in endothelial damage, could be useful biomarkers for the detection of AD-ILD
+ . We recruited patients with rheumatoid arthritis (RA)-ILD+ (n = 21) and systemic sclerosis (SSc)-ILD+ (n = 21). We included comparison groups of patients: RA-ILD− (n = 25), SSc-ILD− (n = 20), and idiopathic pulmonary fibrosis (IPF) (n = 21). Serum levels of these proteins were determined by ELISA. E-selectin, ICAM-1, and ET-1 serum levels were increased in RA-ILD+ and IPF patients in comparison to RA-ILD− patients. Additionally, SSc-ILD+ and IPF patients exhibited higher ICAM-1 levels than those with SSc-ILD− . The ability of E-selectin, ICAM-1, and ET-1 to discriminate RA-ILD+ from RA-ILD− patients, and ICAM-1 to distinguish SSc-ILD+ from SSc-ILD− patients was confirmed using ROC curve analysis. Furthermore, elevated levels of ET-1 and E-selectin correlated with lung function decline in RA-ILD+ and SSc-ILD+ patients, respectively. In conclusion, our findings support the relevant role of E-selectin, ICAM-1, and ET-1 in RA-ILD+ patients as well as of ICAM-1 in SSc-ILD+ patients, constituting potential screening blood biomarkers of ILD in AD. Moreover, this study suggests ET-1 and E-selectin as possible indicators of worsening lung function in RA-ILD+ and SSc-ILD+ patients, respectively. [ABSTRACT FROM AUTHOR]- Published
- 2023
- Full Text
- View/download PDF
42. CCR9/CXCR5 Co-Expressing CD4 T Cells Are Increased in Primary Sjögren's Syndrome and Are Enriched in PD-1/ICOS-Expressing Effector T Cells.
- Author
-
Hinrichs, Anneline C., Kruize, Aike A., Lafeber, Floris P. J. G., Leavis, Helen L., and van Roon, Joel A. G.
- Subjects
SJOGREN'S syndrome ,B cells ,T cells ,MONONUCLEAR leukocytes ,T helper cells ,CELL populations ,CHEMOKINE receptors ,T cell receptors - Abstract
Primary Sjögren's syndrome (pSS) is an autoimmune disease characterised by B cell hyperactivity. CXCR5+ follicular helper T cells (Tfh), CXCR5-PD-1hi peripheral helper T cells (Tph) and CCR9+ Tfh-like cells have been implicated in driving B cell hyperactivity in pSS; however, their potential overlap has not been evaluated. Our aim was to study the overlap between the two CXCR5- cell subsets and to study their PD-1/ICOS expression compared to "true" CXCR5/PD-1/ICOS-expressing Tfh cells. CXCR5- Tph and CCR9+ Tfh-like cell populations from peripheral blood mononuclear cells of pSS patients and healthy controls (HC) were compared using flow cytometry. PD-1/ICOS expression from these cell subsets was compared to each other and to CXCR5+ Tfh cells, taking into account their differentiation status. CXCR5- Tph cells and CCR9+ Tfh-like cells, both in pSS patients and HC, showed limited overlap. PD-1/ICOS expression was higher in memory cells expressing CXCR5 or CCR9. However, the highest expression was found in CXCR5/CCR9 co-expressing T cells, which are enriched in the circulation of pSS patients. CXCR5- Tph and CCR9+ Tfh-like cells are two distinct cell populations that both are enriched in pSS patients and can drive B cell hyperactivity in pSS. The known upregulated expression of CCL25 and CXCL13, ligands of CCR9 and CXCR5, at pSS inflammatory sites suggests concerted action to facilitate the migration of CXCR5+CCR9+ T cells, which are characterised by the highest frequencies of PD-1/ICOS-positive cells. Hence, these co-expressing effector T cells may significantly contribute to the ongoing immune responses in pSS. [ABSTRACT FROM AUTHOR]
- Published
- 2023
- Full Text
- View/download PDF
43. Optimizing Parameters for an Electrical Car Employing Vehicle Dynamics Simulation Program.
- Author
-
Szántó, Attila, Hajdu, Sándor, and Sziki, Gusztáv Áron
- Subjects
SIMULATION software ,PROTOTYPE design & construction ,RACING automobiles ,SIMULATED annealing ,GENERATING functions - Abstract
At the Faculty of Engineering of the University of Debrecen we have dealt with the design and construction of electric prototype race cars for more than a decade. With a focus on more conscious design and racing we developed a vehicle dynamics simulation program, which can be used to generate the dynamics functions of the cars from their technical characteristics and data. In this publication, we deal with the optimization of the technical parameters of the above-mentioned cars for various competition tasks using our simulation program. This is a completely new field of application of the used optimization methods. This concept and idea can effectively help student teams all over the world to prepare for various domestic and international competitions. One of the applied methods is a graphic procedure, the other one is the widely used "adaptive simulated annealing" (ASA). After a brief description of the simulation program, the applied optimization methods and developed MATLAB codes for them are described. Finally, to demonstrate the effectiveness of the methods, we optimize the parameters of a prototype race car for different competition tasks and present the obtained results. [ABSTRACT FROM AUTHOR]
- Published
- 2023
- Full Text
- View/download PDF
44. Association of Human Leukocyte Antigen (HLA) class II (DRB1 and DQB1) alleles and haplotypes with Rheumatoid Arthritis in Sudanese patients.
- Author
-
Ali, Adil Ahmed, Khalid, Khalid Eltahir, Mohammed, Somaya Elhaj, Akhtar, Mohammed Salman, and Saeed, Osman Khalafalla
- Subjects
HLA histocompatibility antigens ,HAPLOTYPES ,RHEUMATOID arthritis ,ALLELES ,SUDANESE - Abstract
The aim of this study was to determine the Human Leukocyte Antigen (HLA) class II (DRB1 and DQB1) alleles and haplotype frequency in Rheumatoid Arthritis (RA) in the Sudanese population. The frequency of HLA-DRB1 and -DQB1 alleles and DRB1-DQB1 haplotypes were determined in 122 RA patients and 100 controls. HLA alleles were genotyped by the polymerase chain reaction-sequence specific primers (PCR-SSP) method. In RA patients, HLA-DRB1*04 and *10 alleles were high in frequency (9.6% vs 14.2%, P = 0.038 and P = 0.042, respectively), and dependently on anti-citrullinated protein antibodies (ACPAs) seropositivity (P = 0.044 and P = 0.027, respectively). In contrast, the frequency of the HLADRB1* 07 allele was significantly low in patients than in controls (11.7% vs 5.0%, P = 0.010). Moreover, the HLA-DQB1*03 allele was strongly associated with RA risk (42.2%, P = 2.2x10-8), whereas, HLA-DQB1*02 and *06 showed protective effects against RA (23.1% and 42.2%, P = 0.024 and P = 2.2x10-6, respectively). Five different HLA haplotypes, DRB1*03-DQB1*03 (P = 0.00003), DRB1*04-DQB1*03 (P = 0.00014), DRB1*08-DQB1*03 (P = 0.027), DRB1*13-DQB1*02 (P = 0.004), and DRB1*13-DQB1*03 (P = 3.79x10-8) were significantly associated with RA risk, while 3 protective haplotypes, DRB1*03-DQB1*02 (Pc = 0.008), DRB1*07-DQB1*02 (Pc = 0.004), and DRB1*13-DQB1*06 (Pc = 0.02) were identified. This is the first study determining the association between HLA class II alleles and haplotypes and RA risk in our population. [ABSTRACT FROM AUTHOR]
- Published
- 2023
- Full Text
- View/download PDF
45. ATO Increases ROS Production and Apoptosis of Cells by Enhancing Calpain-Mediated Degradation of the Cancer Survival Protein TG2.
- Author
-
Jambrovics, Károly, Póliska, Szilárd, Scholtz, Beáta, Uray, Iván P., and Balajthy, Zoltán
- Subjects
NUCLEAR factor E2 related factor ,ACUTE promyelocytic leukemia ,MONONUCLEAR leukocytes ,CANCER stem cells ,PRODUCTION increases - Abstract
Transglutaminase 2 (TG2) is a critical cancer cell survival factor that activates several signalling pathways to foster drug resistance, cancer stem cell survival, metastasis, inflammation, epithelial-mesenchymal transition, and angiogenesis. All-trans retinoic acid (ATRA) and chemotherapy have been the standard treatments for acute promyelocytic leukaemia (APL), but clinical studies have shown that arsenic trioxide (ATO), alone or in combination with ATRA, can improve outcomes. ATO exerts cytotoxic effects in a variety of ways by inducing oxidative stress, genotoxicity, altered signal transduction, and/or epigenetic modification. In the present study, we showed that ATO increased ROS production and apoptosis ratios in ATRA-differentiated NB4 leukaemia cells, and that these responses were enhanced when TG2 was deleted. The combined ATRA + ATO treatment also increased the amount of nuclear factor erythroid 2-related factor 2 (NRF2) transcription factor, an adaptive regulator of the cellular oxidative stress response, and calpain proteolytic activity, resulting in TG2 degradation and the reduced survival of WT leukaemia cells. We further showed that the induced TG2 protein expression was degraded in the MCF-7 epithelial cell line and primary peripheral blood mononuclear cells upon ATO treatment, thereby sensitising these cell types to apoptotic signals. [ABSTRACT FROM AUTHOR]
- Published
- 2023
- Full Text
- View/download PDF
46. VDR Gene Single Nucleotide Polymorphisms and Autoimmunity: A Narrative Review.
- Author
-
Agliardi, Cristina, Guerini, Franca Rosa, Bolognesi, Elisabetta, Zanzottera, Milena, and Clerici, Mario
- Subjects
SINGLE nucleotide polymorphisms ,VITAMIN D receptors ,SCIENTIFIC literature ,VITAMIN D ,AUTOIMMUNITY - Abstract
Simple Summary: The pathogenesis of autoimmune diseases etiology is still mostly unclear and probably arises from an interplay between common/rare genetic variants and environmental factors that act as triggers. Vitamin D and its pathways have been repeatedly associated with the onset of autoimmune diseases. Vitamin D exerts its functions by binding to the Vitamin D receptor (VDR); the complex Vitamin D/VDR regulates many biological functions, including immune responses. In this review, we summarize and discuss data analyzing the possible involvement of the four best studied VDR gene polymorphisms in the pathogenesis of autoimmune conditions, with the aim of better understanding these mechanisms and shedding light on what needs to be further investigated. The vitamin D/Vitamin D receptor (VDR) axis is crucial for human health as it regulates the expression of genes involved in different functions, including calcium homeostasis, energy metabolism, cell growth and differentiation, and immune responses. In particular, the vitamin D/VDR complex regulates genes of both innate and adaptive immunity. Autoimmune diseases are believed to arise from a genetic predisposition and the presence of triggers such as hormones and environmental factors. Among these, a role for Vitamin D and molecules correlated to its functions has been repeatedly suggested. Four single nucleotide polymorphisms (SNPs) of the VDR gene, ApaI, BsmI, TaqI, and FokI, in particular, have been associated with autoimmune disorders. The presence of particular VDR SNP alleles and genotypes, thus, was observed to modulate the likelihood of developing diverse autoimmune conditions, either increasing or reducing it. In this work, we will review the scientific literature suggesting a role for these different factors in the pathogenesis of autoimmune conditions and summarize evidence indicating a possible VDR SNP involvement in the onset of these diseases. A better understanding of the role of the molecular mechanisms linking Vitamin D/VDR and autoimmunity might be extremely useful in designing novel therapeutic avenues for these disorders. [ABSTRACT FROM AUTHOR]
- Published
- 2023
- Full Text
- View/download PDF
47. Efficient reduction of quinoxaline compounds using zinc chloride—sodium borohydride system.
- Author
-
Chen, Yuanguang, Xu, Huashen, Chen, Lu, Shi, Yajie, Hou, Anyuan, Liu, Zhongbo, and Chen, Guoliang
- Subjects
QUINOXALINE compounds ,SODIUM borohydride ,ZINC chloride ,ZINC compounds ,QUINOXALINES - Abstract
Reagent system NaBH
4 —ZnCl2 was found to be suitable for the reduction of various substituted quinoxalines to obtain corresponding 1,2,3,4-tetrahydro derivatives. The reduction proceeds quickly under mild reaction conditions. The procedure is convenient and can be applied for a wide scope of substrates. [ABSTRACT FROM AUTHOR]- Published
- 2023
- Full Text
- View/download PDF
48. [Dr. György Szántó (1907-1982)].
- Author
-
Szántó G
- Subjects
- General Surgery history, History, 20th Century, Hungary, Military Medicine history
- Published
- 1982
49. [Prof. György Szántó, 1907-1982].
- Author
-
Manninger J
- Subjects
- General Surgery history, History, 20th Century, Hungary, Military Medicine history
- Published
- 1982
50. [Prof. György Szántó 70 years old].
- Author
-
Hönig V
- Subjects
- General Surgery history, History, 20th Century, Hungary, Military Medicine history
- Published
- 1977
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