5,072 results on '"G, Casati"'
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2. BOOK REVIEW: 'PRINCIPLES OF QUANTUM COMPUTATION AND QUANTUM INFORMATION, Vol. I: BASIC CONCEPTS, VOL. II: BASIC TOOLS AND SPECIAL TOPICS' BY G. BENENTI, G. CASATI AND G. STRINI
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János A. Bergou
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Physics ,Physics and Astronomy (miscellaneous) ,media_common.quotation_subject ,Presentation ,Open quantum system ,Quantum cryptography ,Quantum error correction ,Quantum mechanics ,ComputingMilieux_COMPUTERSANDEDUCATION ,Mathematics education ,Quantum algorithm ,Quantum information ,Quantum information science ,media_common ,Quantum computer - Abstract
This two-volume book is a great addition to the growing number of books devoted to the field. It is very clearly written by classroom professionals, always with the students in mind. The tutorial presentation is supplemented with a number of exercises whose solutions are also given at the end of each volume. The first volume can serve as a textbook for a one semester introductory course in quantum computation and quantum information. The second volume is more technical and brings the reader to the level of the current literature. It is useful for the specialist, can serve as a textbook for a more advanced course, or has its place as a reference book. In summary, I can highly recommend this book to anyone interested in this field.
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- 2007
3. Stochastic processes in classical and quantum systems. Lecture Notes in Physics 262 S. Albeverio G. Casati D. Merlini
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Georgescu, Adelina
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- 1988
4. Stochastic behavior in classical and quantum hamiltonian systems (Volta Memorial Conference, Como, 1977), Lecture Notes in Physics, 73 G. Casati J. Ford
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Halanay, A.
- Published
- 1987
5. GIOVENTU' ITALICA. La statistica del pensiero G. Casati
- Published
- 1926
6. BOOK REVIEW: "PRINCIPLES OF QUANTUM COMPUTATION AND QUANTUM INFORMATION, Vol. I: BASIC CONCEPTS, VOL. II: BASIC TOOLS AND SPECIAL TOPICS" BY G. BENENTI, G. CASATI AND G. STRINI
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BERGOU, JÁNOS A., primary
- Published
- 2007
- Full Text
- View/download PDF
7. Study of Negative Ion Beamlets Produced in SPIDER by Beam Emission Spectroscopy
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Riccardo Agnello, M. Barbisan, G. Casati, R. Pasqualotto, G. Serianni, and B. Zaniol
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plasma sources ,Nuclear and High Energy Physics ,ion beams ,Condensed Matter Physics - Abstract
Among the beam diagnostics routinely employed in source for production of ion of deuterium (SPIDER), beam emission spectroscopy (BES) provides valuable information for beam characterization, thus driving source optimization methods. In particular, this technique is used to measure beam divergence and uniformity, which are crucial parameters to be optimized for application in International Experimental Thermonuclear Reactor (ITER). In this contribution, we focus on the characterization of H-/D- beamlets extracted during the first SPIDER Cs campaigns. In particular, we show parametric scans and preliminary broad component estimates on single beamlets.
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- 2022
8. P17.13.A Verteporfin inhibits autophagy in glioblastoma cell lines
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G Casati, L Giunti, A Iorio, A Marturano, and I Sardi
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Cancer Research ,Oncology ,Neurology (clinical) - Abstract
Background Glioblastoma (GBM) is the most common primary brain tumor with a poor prognosis, characterized by a high cellular heterogeneity and invasiveness. Multi-drug resistance (MDR), the blood brain barrier (BEE) and DNA repair systems let the survival of tumor cells, making the treatment with chemo and radiotherapy not effective. Autophagy is a physiological mechanism that allows the recycling of damaged proteins and organelles, in order to protect the correct cell turnover. However, in GBM this process promotes survival and proliferation in stressful conditions such as after a chemo and / or radiotherapy treatment. The Hippo pathway is an extremely important molecular signaling because it is involved in various tumorigenesis processes, for instance the epithelium-mesenchymal transition (EMT), in the increase of stemness, mechanotransduction and chemoresistance. Material and Methods The modulation of autophagy was evaluated in GBM cell lines (U87MG, T98G and A172) exploiting a fluorescent detection that allowed the quantification of the autophagosomal activity present into the cell lines. The rate of autophagy was assessed after the cell lines pharmacological treatment with Hippo pathway inhibitors, Verteporfin 2uM (VP) for 24h, Latrunculin 0,5uM (LAT) for 3h and Cytochalasin 1uM (CIT) for 3h, with Doxorubicin 0,5uM (DOX) for 24h and with the drugs combination (DOX-VP, DOX-LAT and DOX-CIT). Moreover, the expression of the autophagy marker LC3II / I was evaluated in all three GBM cell lines by Western Blotting (WB) experiments. To perform this technique, the cells were treated with DOX and Hippo pathway inhibitors respecting the pharmacological treatment previously used. Then, the proteins were extracted, quantified and finally the WB was performed. Results The results obtained showed that the three GBM cell lines without any drugs were marked by high levels of autophagy, similar to the cells treated with Rapamycin, an autophagy inducer. Moreover, the autophagy rate was definitely reduced after treatment with VP and DOX-VP in all three cell lines, including the chemoresistant T98G. Conversely, the other two Hippo pathway inhibitors (LAT-CIT) and DOX did not significantly change the rate of autophagy. The expression of LC3II / I was particularly low after treatment with VP and DOX-VP in all three cell lines while the other two inhibitors did not significantly change its expression. Conclusion In conclusion, these data demonstrated that the three GBM cell lines (U87MG, T98G and A172) are characterized by high levels of autophagy and the inhibition of the Hippo pathway with VP and especially the combination DOX-VP reduced the activation of this protumoral molecular mechanism in GBM cell lines.
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- 2022
9. Negative ion density in the ion source SPIDER in Cs free conditions
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M Barbisan, R Agnello, G Casati, R Pasqualotto, C Poggi, E Sartori, M Spolaore, and G Serianni
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Plasma Physics (physics.plasm-ph) ,cavity ring-down spectroscopy ,Nuclear Energy and Engineering ,Physics::Plasma Physics ,hydrogen ,negative ion source ,neutral beam injector ,FOS: Physical sciences ,Condensed Matter Physics ,Physics - Plasma Physics - Abstract
The SPIDER experiment, operated at the Neutral Beam Test Facility of Consorzio RFX, Padua, hosts the prototype of the H-/D- ion source for the ITER neutral beam injectors. The maximization of the ion current extracted from the source and the minimization of the amount of co-extracted electrons are among the most relevant targets to accomplish. The Cavity Ring-Down Spectroscopy diagnostic measures the negative ion density in the source close to the acceleration system, so as to have feedback information to optimize the source parameters and to maximize the amount of negative ions that can be extracted at optimal beam divergence. This work shows how the magnetic filter field and the bias currents, present in SPIDER to limit the amount of co-extracted electrons and the electron-ion stripping reactions, affect the density of negative ions available for extraction. Moreover, the influence of the extraction process on the density of negative ions available for extraction is also presented. In this study SPIDER was operated in hydrogen and deuterium in Cs-free conditions, therefore negative ions were mostly produced by reactions in the plasma volume., 13 pages, 8 figures. Preprint of a published paper
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- 2022
10. P04.20 The role of YAP in Glioblastoma cell lines
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A Marturano, Iacopo Sardi, Laura Giunti, G Casati, and Anna Lisa Iorio
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Cancer Research ,Cell growth ,Autophagy ,Cancer ,Biology ,medicine.disease ,Cell nucleus ,medicine.anatomical_structure ,Oncology ,Cell culture ,Apoptosis ,Cancer research ,medicine ,Neurology (clinical) ,Signal transduction ,Transcription factor - Abstract
BACKGROUND Glioblastoma (GBM) is a primary human malignant brain tumor, the most common in adults. Several studies have highlighted the Hippo-pathway as a cancer signalling network. The Hippo pathway is an evolutionarily conserved signal cascade, which is involved in the control of organ growth. Dysregulations among this pathway have been found in lung, ovarian, liver and colorectal cancer. The key downstream effector of the Hippo-pathway is the Yes-associated protein (YAP); in the nucleus, its function as transcription co-activator is to interact with transcription factors, resulting in the expression of target genes involved in pro-proliferating and anti-apoptotic programs. MATERIAL AND METHODS Using western blotting analysis, we determined the nuclear expression of YAP on three GBM cell lines (U87MG, T98G and A172). To investigate which inhibitors against the Hippo-pathway were the most efficient, we performed a cytotoxic assay: we treated all the three cell lines with different inhibitors such as Verteporfin (VP), Cytochalasin D (CIT), Latrunculin A (LAT), Dobutamine (DOB) and Y27632. Afterwards, we performed a treatment using Doxorubicin (DOX) combined with the inhibitors, evaluating its cytotoxic effect on our cell lines, through cell viability experiments. More western blotting experiments were performed to investigate the oncogenic role of YAP at nucleus level. Furthermore, preliminary experiments have been conducted in order to investigate the apoptosis, senescence and autophagy modulation due to the Hippo-pathway. RESULTS We showed our cell lines express nuclear YAP. We assessed the efficiency of the main inhibitors against Hippo-pathway, proving that VP, LAT A and CIT show a strong cytostatic effect, linked to time increase; plus we saw a cytotoxic effect on T98G. The association of DOX with selected inhibitors is able to reduce cell viability and nuclear YAP expression rate in all three GBM lines. Finally, preliminary experiments were set up to assess how and if the mechanisms of apoptosis, autophagy and senescence were affected by the Hippo-pathway. The combination of DOX with inhibitors promotes resistance to apoptosis. CONCLUSION Our results show that nuclear YAP is present in all tumor lines, thus confirming that this molecular pathway is functioning in GBM lines. Nuclear YAP is more highly expressed after DOX administration. Moreover, the combined treatment (DOX with Hippo-pathway inhibitors) reduces both cell proliferation and viability, and increases the rate of apoptosis. Preliminary experiments on senescence and autophagy were used to determine the best Hippo-pathway inhibitor. These data demonstrate that the Hippo-pathway plays a crucial role in GBM proliferation and resistance to apoptosis. Inhibiting this pathway and in particular the transcription factor YAP, in association with DOX, might be an excellent therapeutic target.
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- 2021
11. P06.07 Germline mutation of SMARCE1 gene in a family with spinal meningiomas
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Laura Giunti, Lorenzo Genitori, Anna Lisa Iorio, V Serio, G Casati, E Fiorentini, Annamaria Buccoliero, A Marturano, B Rinaldi, and Iacopo Sardi
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Cancer Research ,Germline mutation ,Oncology ,Spinal Meningiomas ,Cancer research ,Neurology (clinical) ,Biology ,SMARCE1 Gene - Abstract
BACKGROUND Meningioma is the most common benign primary intracranial tumor, arising from arachnoid cells of the meninges, but in 20% of cases displays aggressive behavior. Meningiomas are mainly sporadic and the familial forms are very rare. Meningioma account for a small subset (1–4%) of all pediatric brain tumors and may be associated with hereditary tumor predisposition syndrome caused by germline mutations of NF2, SMARCB1, SUFU, and SMARCE1 genes. MATERIAL AND METHODS We present a case of a 16-year-old girl with spinal clear cell meningiomas (CCMs) WHO II with a second spinal lesion identified during the follow-up. Considering the multiple lesions, we performed Whole Exome Sequencing (WES) on DNA from peripheral blood to search for an underlying CCMs tumor predisposition syndrome (#607174). RESULTS We identified a heterozygous frameshift variant c.439delA (p.Ser147fs) in SMARCE1, chromatin remodelling factor that acts as a tumor suppressor gene. Meningioma analysis by Sanger sequencing showed a loss of heterozygosity (LOH) of the wild-type allele. We identified the c.439delA in the constitutional DNA of the father and the sister but not in the mother. At the moment, the father is asymptomatic and the 14 years old sister showed two spinal lesions (meningiomas likely) at the first MRI. CONCLUSION We report a family study of hereditary tumor predisposition syndrome to CCMs with SMARCE1 mutation in which are present two asymptomatic carriers with different ages and gender. The asymptomatic carriers will undergo neurological examination and MRI of the brain and spine, according to a screening protocol. The incomplete penetrance phenomenon is known in SMARCE1-related families with CCMs and it is probably due to the interaction of SMARCE1 with yet unidentified genes.
- Published
- 2021
12. Stochastic processes in classical and quantum systems S. Albeverio, G. Casati, and D. Merlini, Springer, 1986, 551 pp
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Rota, Gian-Carlo
- Full Text
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13. The Interrogation Footprint of RFID-UAV: Electromagnetic Modeling and Experimentations
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D Latini, Sara Amendola, Gaetano Marrocco, G. Casati, Giovanni Schiavon, M. Longhi, Francesco Carbone, and F. Del Frate
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Computer science ,business.industry ,Organic Chemistry ,Real-time computing ,Settore ING-INF/02 - Campi Elettromagnetici ,Effective radiated power ,Biochemistry ,Drone ,Footprint ,Airframe ,Computational electromagnetics ,Wireless ,ComputerSystemsOrganization_SPECIAL-PURPOSEANDAPPLICATION-BASEDSYSTEMS ,Sensitivity (control systems) ,Omnidirectional antenna ,business - Abstract
The combined use of unmanned aerial vehicles (UAV) and radiofrequency identification (RFID) devices is an emerging topic of the environmental monitoring, which combines the versatility of multi-copter airframes with the potentiality of low-cost wireless sensors. This paper introduces some performance metrics suitable to quantify the capability of an RFIDrone to scan a surface equipped with radio-sensors. By using simple propagation models, an optimal drone-surface distance is mathematically derived at the purpose to maximize the electromagnetic footprint for the specific choice of system parameters, such as the sensor type and position, the reader sensitivity, the ground reflectivity, the radiated power, and the flight velocity. Theoretical achievements and some preliminary experimentations indicate that omnidirectional antennas are preferred for the drone so that 9–12 m footprints could be achieved with state-of-the-art readers and battery-less or battery-assisted RFID sensors, provided that the UAV flights at 3–5 m from the surface to be monitored. In this condition, the hit-rate of arrays of tags is better than 90% for a flying speed less than 1.8 km/h. The read performance is instead sensibly degraded by the presence of multi path in case of sensors spaced out the surface.
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- 2017
14. One-Dimensional Self-Organization and Nonequilibrium Phase Transition in a Hamiltonian System
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G. Casati and Jiao Wang
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Physics ,Phase transition ,Statistical Mechanics (cond-mat.stat-mech) ,Condensed matter physics ,Classical Physics (physics.class-ph) ,FOS: Physical sciences ,General Physics and Astronomy ,Non-equilibrium thermodynamics ,Physics - Classical Physics ,Critical value ,01 natural sciences ,Power law ,010305 fluids & plasmas ,Hamiltonian system ,Thermal conductivity ,0103 physical sciences ,Exponent ,Dissipative system ,010306 general physics ,Condensed Matter - Statistical Mechanics - Abstract
Self-organization and nonequilibrium phase transitions are well known to occur in two- and three- dimensional dissipative systems. Here, instead, we provide numerical evidence that these phenomena also occur in a one-dimensional Hamiltonian system. To this end, we calculate the heat conductivity by coupling the two ends of our system to two heat baths at different temperatures. It is found that when the temperature difference is smaller than a critical value, the heat conductivity increases with the system size in power law with an exponent considerably smaller than 1. However, as the temperature difference exceeds the critical value, the system's behavior undergoes a transition and the heat conductivity tends to diverge linearly with the system size. Correspondingly, an ordered structure emerges. These findings suggest a new direction for exploring the transport problems in one dimension., 5 pages, 4 figures
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- 2016
15. RFIDrone: Preliminary experiments and electromagnetic models
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G. Marrocco, F. Del Frate, M. Longhi, Daniele Latini, G. Casati, and Francesco Carbone
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Scanner ,Electromagnetics ,Computer science ,Scattering ,020208 electrical & electronic engineering ,Settore ING-INF/02 - Campi Elettromagnetici ,ComputerApplications_COMPUTERSINOTHERSYSTEMS ,020206 networking & telecommunications ,02 engineering and technology ,Identification (information) ,0202 electrical engineering, electronic engineering, information engineering ,Electronic engineering ,ComputerSystemsOrganization_SPECIAL-PURPOSEANDAPPLICATION-BASEDSYSTEMS ,Electromagnetic model ,Sensitivity (control systems) ,Remote sensing - Abstract
We introduce in a unitary way the paradigm of radiofrequency identification (RFID) merged with the technology of Unmanned Aerial Vehicles (UAV) giving rise to RFIDrone devices. Such family comprises the READER-Drone, which is a suitable UAV integrated with an autonomous RFID reader to act as mobile scanner of the environment, and the TAG-Drone, a UAV only equipped with an RFID sensor tag that hence becomes a mobile and automatically re-positioned sensor. We shows some handy electromagnetic models to identify the upper-bound communication performance of RFIDrone in close proximity of a scattering surface and we resume the results of some preliminary open-air experimentation corroborating the theoretical analysis.
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- 2016
16. Quantum Computation of Complex Systems
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G. Casati and Giuliano Benenti
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Quantum technology ,Quantum network ,Open quantum system ,Quantum error correction ,ComputerSystemsOrganization_MISCELLANEOUS ,Quantum mechanics ,TheoryofComputation_GENERAL ,Quantum simulator ,Quantum algorithm ,Statistical physics ,Quantum information ,Mathematics ,Quantum computer - Abstract
Simulating quantum mechanical systems is known to be a difficult computational problem. In particular, for many-body quantum systems the size of the Hilbert space grows exponentially with the number of particles. On the other hand, the growth in memory requirement is only polynomial on a quantum computer, which is itself a many-body quantum system. Therefore, a quantum computer operating with only a few tens of qubits would outperform a classical computer. Moreover, quantum computers with only about ten qubits could efficiently simulate complex single-particle quantum dynamical systems.
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- 2016
17. Inhibition of YAP activation induces cell senescence and autophagy while blocking cell proliferation in cholangiocarcinoma (CCA)
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Chiara Milani, G. Maria, Luca Fabris, Umberto Cillo, Massimiliano Cadamuro, Eleanna Kaffe, R. Fiorotto, G. Casati, M. Strazzabosco, Valeria Mariotti, Tommaso Stecca, Simone Brivio, Carlo Spirli, and Mariangela Amenduni
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Senescence ,medicine.anatomical_structure ,Hepatology ,Cell growth ,Chemistry ,Blocking (radio) ,Cell ,Autophagy ,medicine ,Cell biology - Published
- 2018
18. Classical Dynamical Localization
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Italo Guarneri, G. Casati, and Volker Karle
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Nonlinear Sciences::Chaotic Dynamics ,Physics ,Quantum Physics ,Classical mechanics ,Dynamical systems theory ,FOS: Physical sciences ,Physics::Accelerator Physics ,General Physics and Astronomy ,External field ,Quantum Physics (quant-ph) ,Quantum ,Quantum chaos - Abstract
We consider classical models of the kicked rotor type, with piecewise linear kicking potentials designed so that momentum changes only by multiples of a given constant. Their dynamics display quasi-localization of momentum, or quadratic growth of energy, depending on the arithmetic nature of the constant. Such purely classical features mimic paradigmatic features of the {\it quantum} kicked rotor, notably dynamical localization in momentum, or quantum resonances. We present a heuristic explanation, based on a classical phase space generalization of a well known argument, that maps the quantum kicked rotor on a tight-binding model with disorder. Such results suggest reconsideration of generally accepted views, that dynamical localization and quantum resonances are a pure result of quantum coherence.
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- 2014
19. Is CIMT a rehabilitative practice for everyone? Predictive factors and feasibility
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S, Fabbrini, G, Casati, and D, Bonaiuti
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Aged, 80 and over ,Male ,Restraint, Physical ,Hand Strength ,Stroke Rehabilitation ,Hemiplegia ,Recovery of Function ,Middle Aged ,Motor Activity ,Exercise Therapy ,Stroke ,Upper Extremity ,Treatment Outcome ,Italy ,Predictive Value of Tests ,Feasibility Studies ,Humans ,Female ,Aged - Abstract
Constraint Induced Movement Therapy (CIMT) in hemiplegic patient is an efficacious method for upper limb rehabilitation.To verify the applicability of CIMT in post stroke inpatients and to verify the predictive value of some clinical and functional independent variables on the outcomes, in order to identify a population of subjects to which this technique can be more effective.Non-controlled clinical study.Seven Italian, non-experimental, Rehabilitation Departments.All post-stroke inpatients (subacute and chronic), consecutively admitted in 7 Rehabilitation Departments, were screened according to our inclusion criteria. The eligible population was assessed according to selected clinical and functional variables at the baseline, and it was evaluated with Wolf Motor Function Test (WMFT-FAS and WMFT-PTT) and Motor Activity Log (MAL-AOU and MAL-QOM), before treatment (T0), after treatment (T1) and at a 3-month follow up (T2). Patients underwent 2 weeks of CIMT from T0.Of the 600 inpatients screened, 44 were admitted in the CIMT protocol and were evaluated at T0 and T1; just 24 completed the assessment at T2. At the end of treatment NIHSS and Motricity Index (MI) were predictive factors of MAL scores, while Geriatric Depression Scale (GDS), Modified Barthel Inedx (MBI) and MI were predictive factors of WMFT scores. At the follow up NIHSS and GDS remained predictive factors of MAL scores, and MBI was predictive of WMFT FAS score.CIMT efficacy did not result to be related to patient's age, mild cognitive deficit, time since stroke. Depression and pinch ability are the main predictors of motor recovery. Despite the demonstrated efficacy, CIMT feasibility still needs to be demonstrated, considering the low percentage (6.5%) of eligibility among all stroke inpatients.CIMT requires high costs and resources; therefore it is valuable to know the predictive factors which help select the eligible patients. It is then useful to recognize the risk factors of developing Learned Non Use after stroke.
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- 2014
20. Impact of plasma treatment time on MOCVD-TiN properties and on the electrical performance of deep contacts
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G. Casati, G. Queirolo, F. Cazzaniga, G. Pavia, S. Alberici, A. Sabbadini, V. Cusi, and C. Bresolin
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business.industry ,Contact resistance ,Nucleation ,chemistry.chemical_element ,Plasma ,equipment and supplies ,Condensed Matter Physics ,Atomic and Molecular Physics, and Optics ,Surfaces, Coatings and Films ,Electronic, Optical and Magnetic Materials ,Barrier layer ,Optics ,chemistry ,Metallizing ,Electrical and Electronic Engineering ,Thin film ,Composite material ,business ,Tin ,Layer (electronics) - Abstract
MOCVD-TiN deposition from TDMAT precursor consists of two steps: a deposition and a plasma treatment in hydrogen. The effects of different plasma treatment times are tested on high aspect ratio contacts, finding an increase in the number of high resistance contacts for short plasma treatments. Moreover, the W nucleation layer thickness on MOCVD-TiN is impacted by the plasma time: for a short treatment a thin nucleation layer is found. Various investigations are performed on different MOCVD-TiN layers, comparing samples exposed to the air and samples in-situ capped by Ti to prevent oxygen contamination. It is shown that the plasma treatment influences the film morphology.
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- 2001
21. LDL physical properties, lipoprotein and Lp(a) levels in acromegalic patients. Effects of octreotide therapy
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Enzo Manzato, Cristina Rossi, Giovanni Faglia, Giovanni Sartore, G. Casati, and Maura Arosio
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medicine.medical_specialty ,biology ,Cholesterol ,business.industry ,Insulin ,medicine.medical_treatment ,Octreotide ,Lipoprotein(a) ,medicine.disease ,Glucagon ,chemistry.chemical_compound ,Endocrinology ,chemistry ,Internal medicine ,Acromegaly ,medicine ,biology.protein ,lipids (amino acids, peptides, and proteins) ,Cardiology and Cardiovascular Medicine ,business ,medicine.drug ,Lipoprotein ,Hormone - Abstract
High vascular morbidity and mortality is associated with acromegaly. The aim of the present study was to assess the effects of octreotide therapy on several known cardiovascular risk factors and to correlate them with octreotide-induced hormonal changes. Lipid levels, LDL particle size distribution as evaluated by single vertical spin density gradient ultracentrifugation, apolipoproteins AI and B, lipoprotein (a) [Lp(a)] concentrations and apo(a) phenotypes were evaluated in 20 non-diabetic acromegalic patients (6 M, 14 F), with normal thyroid, adrenal and gonadal function, aged 29‐66 years. Normal subjects (20), matched for age, sex and BMI served as control for lipid variables. Acromegalic patients were characterized by lower HDL cholesterol (and apoA-I) and by higher Lp(a) concentrations in comparison to controls. Treatment with octreotide (100 mg t.i.d. for 3 months) led to: an increase in HDL cholesterol (median: 22%), a decrease in LDL cholesterol ( 14%) and a decrease of the Lp(a) levels (all phenotypes) (28%). The expected decreases of IGF-I levels (median: 48%) and 7-h AUC of GH ( 50%), insulin (40%), and glucagon (20%) were observed. Only Lp(a) modifications showed a correlation with GH modifications. The study of LDL physical properties showed that acromegalic patients had smaller and:or more dense LDL particles, in comparison with normal controls (relative flotation rate, Rf: 0.4090.03 versus 0.429 0.02 PB 0.05), an alteration that might contribute to the high vascular risk of acromegalic patients. However, the LDL subfraction distribution remained unmodified during octreotide therapy (Rf 0.3990.03). In conclusion, this study shows that in acromegalic patients octreotide treatment is indeed associated with an amelioration of some lipoprotein parameters, i.e. LDL, HDL, and Lp(a) concentrations. However, this treatment has no effect on the small and:or dense LDL particles present in these patients. © 2000 Elsevier Science Ireland Ltd. All rights reserved.
- Published
- 2000
22. Circulating levels of growth hormone, insulin-like growth factor-I and prolactin in normal, growth retarded and anencephalic human fetuses
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Giovanna Gambino, Paolo Beck-Peccoz, G. Casati, Maura Arosio, Eva Palmieri, A.M. Baggiani, Donatella Cortelazzi, and Luca Persani
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Male ,endocrine system ,medicine.medical_specialty ,Endocrinology, Diabetes and Metabolism ,medicine.medical_treatment ,Gestational Age ,Biology ,Insulin-like growth factor ,Endocrinology ,Pregnancy ,Internal medicine ,Anencephaly ,medicine ,Humans ,Insulin-Like Growth Factor I ,Fetus ,Fetal Growth Retardation ,Growth factor ,Gestational age ,medicine.disease ,Prolactin ,Growth Hormone ,Gestation ,Female ,hormones, hormone substitutes, and hormone antagonists - Abstract
We measured growth hormone (GH), insulin-like growth factor-I (IGF-I), and both total and glycosylated prolactin (PRL) levels in 131 blood samples obtained by cordocentesis in normal and abnormal fetuses from 19 to 40 weeks of gestation. In normal fetuses, IGF-I and PRL levels showed a positive correlation and GH a negative correlation with gestational age. A negative relation between GH and IGF-I levels was observed, while PRL did not show any correlation with both GH and IGF-I concentrations. IGF-I increased from 5.6 +/- 3 (at 19-22 weeks) to 10.7 +/- 5 nmol/l at term; GH decreased from 31 +/- 10 to 7.7 +/- 4 micrograms/l and PRL increased from 16 +/- 18 to 139 +/- 76 micrograms/l. Glycosylated PRL accounted for about 15% of total PRL, a value similar to that found in normal adults. In 27 fetuses of 27-37 weeks with intra-uterine growth retardation, GH and PRL levels were higher and IGF-I levels lower than in normal fetuses matched for week of gestation. In 8 anencephalic fetuses of 19-26 weeks of gestation, both GH and IGF-I levels were lower, and PRL levels were higher than in matched controls. Altogether these data support the views that a) both GH and PRL secretion are under the hypothalamic control during fetal development, b) the serum GH decrease from midgestation to the end of pregnancy is mediated by the negative feed-back mechanism of increasing IGF-I levels and c) IGF-I production is mainly regulated by fuel supply and only partially by GH.
- Published
- 1995
23. AGATA-Advanced GAmma Tracking Array
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A. Colombo, Y. Mariette, A. Johnson, W. Korten, A. Brondi, T. Faul, J. Robin, R. Depalo, M. Slee, J. Gre¸bosz, H. C. Boston, H. Harroch, B. Rossé, M. Filliger, M. Gulmini, A. Korichi, S. Brambilla, J.R. Cresswell, C. Parisel, P. Edelbruck, F. Ameil, F. Camera, C. Oziol, Matthew Richard Dimmock, G. Salvato, F. Morbiducci, J. Ropert, M. Borsato, E. Legay, Marco Bellato, C. Santos, Gheorghe Pascovici, L. Charles, J. Pancin, G. Casati, P. G. Bizzeti, T. Stanios, S. Lhenoret, Diego Barrientos, P.M. Jones, Andreas Görgen, V. Chambert, S. Aydin, K. Hauschild, B. Hervieu, R. Nicolini, J. Simpson, H. J. Wollersheim, L. Lavergne, Pär-Anders Söderström, G. S. Simpson, G. Jaworski, F. Filmer, R. Griffiths, P.S. Morrall, M. Petcu, G. Lo Bianco, D. Linget, A. Givechev, D. C. Oxley, M. Kogimtzis, F. Salomon, J. Jolie, D. Wells, S. Moon, C. Aufranc, A. Corsi, T. Descombes, N. Goel, J. Thornhill, N. Warr, Serkan Akkoyun, B. Birkenbach, F. Dorangeville, Joël Chavas, P. Medina, Roberto Isocrate, C. Weber, E. Merchan, Bo Cederwall, I. Kojouharov, Enrique Sanchis, A. Lopez-Martens, Oliver Wieland, F. Le Blanc, D. Seddon, S. C. Letts, D. Bazzacco, J. Leske, B. Bruyneel, Alberto Pullia, L. Nelson, G. La Rana, B. Travers, I. Burrows, G. Maron, S. Coelli, J. J. Valiente-Dobón, F. Saillant, Piotr Bednarczyk, V.L. Ngo, J. Mierzejewski, Norbert Pietralla, R.S. Kempley, N. Kurz, M. Rebeschini, S. Fantinel, D. L. Balabanski, A. J. Boston, F. Tomasi, R. Berthier, M. D. Salsac, B. Dulny, C. Stahl, N. Dosme, C. Fanin, R. Baumann, S. Pietri, A. Astier, M. Nicoletto, J. van der Marel, A. Bracco, Björn Jonson, D. Mengoni, D. Bloor, Luna Pellegri, F. Lefebvre, D. Pugnére, J. Egea, S. Cabaret, D. Curien, M. Reese, C. Commeaux, Dirk Rudolph, A. Giannatiempo, F. Recchia, L. Ramina, A. Lermitage, C. A. Ur, R. M. Lieder, I.P. Brawn, R. Menegazzo, R. Raine, Krasimir Mitev, D. R. Napoli, G. Suliman, M. Kebbiri, Y. Drouen, Susan Rigby, W. Me¸czyński, R. Wadsworth, F. Didierjean, P. Desesquelles, Ch. Veyssiere, S. Leoni, Vicente González, P. Gros, Y. Le Noa, M. Castoldi, O. Möller, R. Orlandi, Thomas Beck, M. Şenyiğit, A. Jungclaus, L. Gibelin, Mohammed Kaci, Zs. Podolyák, J. Gerl, S. Erturk, W. Gast, B. Melon, V. Mendéz, R. Peghin, P. Molini, M. N. Erduran, D. Conventi, Pankaj S. Joshi, E. Clément, F.A. Beck, A. Austin, A. Cortesi, J. Palin, P. Cocconi, L. J. Harkness, F. C. L. Crespi, Dirk Weisshaar, P. Sona, A. Czermak, D. Lersch, N. Blasi, Anton Khaplanov, O. Stezowski, B. Rubio, R. Venturelli, M.-H. Sigward, E. Viscione, José Salt, C. S. Özben, Giancarlo Ripamonti, P. Spolaore, Johan Nyberg, S. M. Lenzi, L. Legeard, N. Redon, C. Rossi Alvarez, C. He, R. Chapman, P. Le Pouhalec, C. Diarra, Herbert Hess, T. Engert, A. Kaşkaş, Stanislav Tashenov, S. Klupp, C. Michelagnoli, Elif Ince, A. Algora, J. F. Smith, M. Ozille, Alessandro Zucchiatti, Angelo Geraci, A. Olariu, M. Labiche, N. Karkour, Stefano Riboldi, P. Bourgault, C. M. Petrache, M. Palacz, M. El Chambit, J.-L. Cercus, M. Zie¸bliński, Alex Wiens, R. Beunard, X. Lafay, T. Habermann, M. Karolak, L. Costa, Y. Aubert, Begoña Quintana, A P Robinson, V. F. E. Pucknell, D. Rosso, A. Capsoni, Emanuele Vardaci, L. Mihailescu, M. Tripon, E. Farnea, Ch. Theisen, Enrico Calore, G. Duchêne, N. V. Zamfir, X. Grave, S. Lunardi, I.H. Lazarus, José Blasco, D. Montanari, J.A. Sampson, P. H. Regan, N. Marginean, M. Pignanelli, L. Arnold, G. Benzoni, R. Krücken, G. de Angelis, D.P. Scraggs, I. Piqueras, D. M. Cullen, A. Obertelli, A. Bürger, D. Bortolato, G. Rainovski, A.R. Mather, P. Reiter, C. Unsworth, G. Baulieu, P. J. Coleman-Smith, C. Boiano, M. Richer, Sébastien Perrier, Agnese Giaz, Reynold J. Cooper, V. Vandone, S. Tanguy, C. Domingo-Pardo, A. Bouty, A. N. Grint, A. Maj, A. Gottardo, L. Berti, E. Pachoud, R. Marginean, E. A. Stefanova, A. Triossi, M. Nespolo, D. Bucurescu, R. Moro, H.T.M. Ha, D. S. Judson, J. L. Tain, A. Perego, Francesco Lelli, P. Detistov, B.Y. Ky, J. Ljungvall, B. Sowicki, M. Schlarb, F. Azaiez, P. Pariset, Ertan Şahin, R. Gernhäuser, M. Turcato, John Paul Strachan, B. Million, A. Atac, F. Carrio, D. Delbourg, F. Veronese, Th. Kröll, B. Cahan, A. Hernandez-Prieto, M. A. Bentley, K.M.M. Tun-Lanoë, B. Alikhani, P. Boutachkov, S. Leboutelier, Maria Doncel, A. M. Bizzeti-Sona, R. Touzery, A. Nannini, A. Lotode, P. J. Nolan, G. Rampazzo, F. Zocca, H. Schaffner, J. Eberth, A. Gadea, N. Toniolo, T. Hüyük, Q.T. Doan, P. Petkov, S. Broussard, S. Badoer, M. Rigato, Philip M Walker, J. Pouthas, Ch. Finck, L. Milechina, M. Norman, E. Pierre, J. Roccaz, S.J. Colosimo, Lázaro Guevara, Glyn Wittwer, Millan, Vicente Gonzalez -- 0000-0001-6014-2586, Rainovski, Georgi -- 0000-0002-1729-0249, Jaworski, Grzegorz -- 0000-0003-2241-0329, KORTEN, Wolfram -- 0000-0002-3940-0816, Domingo-Pardo, Cesar -- 0000-0002-2915-5466, Triossi, Andrea -- 0000-0001-5140-9154, Huyuk, Tayfun -- 0000-0003-0597-9767, Ince, Elif -- 0000-0003-4821-5441, Algora, Alejandro -- 0000-0002-5199-1794, Calore, Enrico -- 0000-0002-2301-3838, Rubio, Berta -- 0000-0002-9149-4151, THEISEN, Christophe -- 0000-0002-8509-1022, Rudolph, Dirk -- 0000-0003-1199-3055, Gadea, Andres -- 0000-0002-4233-1970, santos, cayetano -- 0000-0003-0727-1914, nannini, adriana -- 0000-0003-0659-7648, Depalo, Rosanna -- 0000-0003-3943-7982, Suliman, gabriel -- 0000-0001-8475-1992, Blasco, Jose-Maria -- 0000-0002-7663-9092, Petrache, Costel -- 0000-0001-8419-1390, Pietralla, Norbert -- 0000-0002-4797-3032, Cederwall, Bo -- 0000-0003-1771-2656, Zucchiatti, Alessandro -- 0000-0002-3647-596X, Mendez Munoz, Victor -- 0000-0002-9044-1189, Kruecken, Reiner -- 0000-0002-2755-8042, Napoli, Daniel Ricardo -- 0000-0002-8154-6958, Tain, Jose L. -- 0000-0002-3263-6965, SANCHIS, ENRIQUE -- 0000-0002-9689-9131, Zieblinski, Miroslaw -- 0000-0002-8693-7317, Hauschild, Karl -- 0000-0003-2862-2445, Montanari, Daniele -- 0000-0002-1980-7686, senyigit, menekse -- 0000-0002-2408-4419, La Rana, Giovanni -- 0000-0003-2814-4113, Menegazzo, Roberto -- 0000-0002-3060-5276, Soderstrom, Par-Anders -- 0000-0002-9504-2814, Unsworth, Carl -- 0000-0002-4100-7466, Camera, Franco -- 0000-0003-1731-4834, Gorgen, Andreas -- 0000-0003-1916-9941, Hernandez Prieto, Alvaro -- 0000-0002-0340-0240, Recchia, Francesco -- 0000-0002-8428-0112, de France, Gilles -- 0000-0002-7439-1759, GOTTARDO, Andrea -- 0000-0002-0390-5767, Perrier, Sebastien -- 0000-0001-5055-9046, Sowicki, Bogdan -- 0000-0002-7208-0690, Robinson, Andrew -- 0000-0002-2510-1321, Sahin, Eda -- 0000-0003-0683-5140, Pullia, Alberto -- 0000-0002-6393-747X, Lelli, Francesco -- 0000-0003-1900-9171, Clement, Emmanuel -- 0000-0003-1887-717X, benzoni, giovanna -- 0000-0002-7938-0338, Jonson, Bjorn -- 0000-0002-9697-9115, Bednarczyk, Piotr -- 0000-0002-5699-5292, Jones, Pete -- 0000-0001-7480-6603, Nicoletto, Marino -- 0000-0001-9301-0782, Ripamonti, Giancarlo -- 0000-0002-9406-021X, Bentley, Michael -- 0000-0001-8401-3455, Pellegri, Luna -- 0000-0002-3227-3332, Barrientos, Diego -- 0000-0001-9693-2942, GIAZ, Agnese -- 0000-0002-2550-450X, [Boston, A. J. -- Boston, H. C. -- Colosimo, S. -- Cooper, R. J. -- Cresswell, J. R. -- Dimmock, M. R. -- Filmer, F. -- Grint, A. N. -- Harkness, L. J. -- Judson, D. S. -- Mather, A. R. -- Moon, S. -- Nelson, L. -- Nolan, P. J. -- Norman, M. -- Oxley, D. C. -- Rigby, S. -- Sampson, J. -- Scraggs, D. P. -- Seddon, D. -- Slee, M. -- Stanios, T. -- Thornhill, J. -- Unsworth, C. -- Wells, D.] Univ Liverpool, Oliver Lodge Lab, Liverpool L69 7ZE, Merseyside, England -- [Akkoyun, S. -- Atac, A. -- Kaskas, A. -- Senyigit, M.] Ankara Univ, Fac Sci, Dept Phys, TR-06100 Ankara, Turkey -- [Algora, A. -- Barrientos, D. -- Domingo-Pardo, C. -- Egea, J. -- Gadea, A. -- Hueyuek, T. -- Kaci, M. -- Mendez, V. -- Rubio, B. -- Salt, J. -- Tain, J. L.] Univ Valencia, CSIC, IFIC, E-46980 Paterna, Spain -- [Alikhani, B. -- Boutachkov, P. -- Givechev, A. -- Goel, N. -- Leske, J. -- Merchan, E. -- Moeller, O. -- Pietralla, N. -- Reese, M. -- Stahl, C.] Tech Univ Darmstadt, IKP, D-64289 Darmstadt, Germany -- [Ameil, F. -- Beck, T. -- Boutachkov, P. -- Domingo-Pardo, C. -- Engert, T. -- Gerl, J. -- Goel, N. -- Habermann, T. -- Kojouharov, I. -- Kurz, N. -- Merchan, E. -- Pietri, S. -- Schaffner, H. -- Tashenov, S. -- Wollersheim, H. J.] GSI Helmholtzzentrum Schwerionenforsch GmbH, D-64291 Darmstadt, Germany -- [de Angelis, G. -- Badoer, S. -- Berti, L. -- Calore, E. -- Cocconi, P. -- Conventi, D. -- Costa, L. -- Fantinel, S. -- Gadea, A. -- Gottardo, A. -- Gulmini, M. -- He, C. -- Ince, E. -- Kroell, Th. -- Lelli, F. -- Maron, G. -- Molini, P. -- Napoli, D. R. -- Rigato, M. -- Rosso, D. -- Sahin, E. -- Spolaore, P. -- Toniolo, N. -- Valiente-Dobon, J. J.] Ist Nazl Fis Nucl, Lab Nazl Legnaro, IT-35020 Padua, Italy -- [Arnold, L. -- Baumann, R. -- Beck, F. A. -- El Chambit, M. -- Charles, L. -- Curien, D. -- Didierjean, F. -- Duchene, G. -- Faul, T. -- Filliger, M. -- Finck, Ch. -- Medina, P. -- Pachoud, E. -- Parisel, C. -- Piqueras, I. -- Richer, M. -- Robin, J. -- Santos, C. -- Sigward, M. -H. -- Weber, C.] Univ Strasbourg, IPHC, F-67037 Strasbourg, France -- [Arnold, L. -- Baumann, R. -- Beck, F. A. -- El Chambit, M. -- Charles, L. -- Curien, D. -- Didierjean, F. -- Duchene, G. -- Faul, T. -- Filliger, M. -- Finck, Ch. -- Medina, P. -- Pachoud, E. -- Parisel, C. -- Piqueras, I. -- Richer, M. -- Robin, J. -- Santos, C. -- Sigward, M. -H. -- Weber, C.] CNRS, UMR 7178, F-67037 Strasbourg, France -- [Astier, A. -- Cabaret, S. -- Desesquelles, P. -- Dosme, N. -- Gibelin, L. -- Ha, H. T. M. -- Hauschild, K. -- Karkour, N. -- Korichi, A. -- Lafay, X. -- Leboutelier, S. -- Legay, E. -- Lhenoret, S. -- Linget, D. -- Ljungvall, J. -- Lopez-Martens, A. -- Morbiducci, F. -- Ngo, V. L. -- Pariset, P. -- Perrier, S. -- Pierre, E. -- Roccaz, J. -- Travers, B.] Univ Paris 11, CNRS, IN2P3, CSNSM, F-91405 Orsay, France -- [Atac, A. -- Nyberg, J. -- Soderstrom, P. -A.] Uppsala Univ, Dept Phys & Astron, Uppsala, Sweden -- [Atac, A. -- Cederwall, B. -- Johnson, A. -- Khaplanov, A. -- van der Marel, J. -- Milechina, L. -- Tashenov, S.] Royal Inst Technol, SE-10691 Stockholm, Sweden -- [Aubert, Y. -- Azaiez, F. -- Le Blanc, F. -- Cercus, J. -L. -- Chambert, V. -- Commeaux, C. -- Delbourg, D. -- Diarra, C. -- Dorangeville, F. -- Edelbruck, P. -- Grave, X. -- Guevara, L. -- Harroch, H. -- Ky, B. Y. -- Lavergne, L. -- Lefebvre, F. -- Lermitage, A. -- Olariu, A. -- Oziol, C. -- Petrache, C. -- Pouthas, J. -- Salomon, F. -- Tanguy, S. -- Tun-Lanoe, K. M. M.] Univ Paris 11, CNRS, IN2P3, IPNO, F-91406 Orsay, France -- [Aufranc, C. -- Baulieu, G. -- Doan, Q. T. -- Pugnere, D. -- Redon, N. -- Rosse, B. -- Stezowski, O.] Univ Lyon 1, CNRS, IN2P3, Inst Phys Nucl Lyon, F-69622 Villeurbanne, France -- [Austin, A. -- Burrows, I. -- Coleman-Smith, P. J. -- Griffiths, R. -- Kogimtzis, M. -- Labiche, M. -- Lazarus, I. H. -- Letts, S. C. -- Morrall, P. S. -- Palin, J. -- Pucknell, V. F. E. -- Simpson, J. -- Strachan, J.] STFC Daresbury Lab, Warrington WA4 4AD, Cheshire, England -- [Aydin, S. -- Bazzacco, D. -- Bellato, M. -- Bortolato, D. -- Chavas, J. -- Colombo, A. -- Fanin, C. -- Farnea, E. -- Isocrate, R. -- Kroell, Th. -- Lenzi, S. M. -- Lunardi, S. -- Marginean, R. -- Menegazzo, R. -- Mengoni, D. -- Michelagnoli, C. -- Nespolo, M. -- Nicoletto, M. -- Peghin, R. -- Ramina, L. -- Rampazzo, G. -- Rebeschini, M. -- Recchia, F. -- Rossi Alvarez, C. -- Salvato, G. -- Triossi, A. -- Turcato, M. -- Ur, C. A. -- Venturelli, R. -- Veronese, F.] Ist Nazl Fis Nucl, Sez Padova, IT-35131 Padua, Italy -- [Balabanski, D. L. -- Detistov, P. -- Petkov, P. -- Stefanova, E.] Bulgarian Acad Sci, Inst Nucl Res & Nucl Energy, Sofia, Bulgaria -- [Bednarczyk, P. -- Czermak, A. -- Dulny, B. -- Grebosz, J. -- Maj, A. -- Meczynski, W. -- Sowicki, B. -- Zieblinski, M.] Polish Acad Sci, Henryk Niewodniczanski Inst Nucl Phys, PL-31342 Krakow, Poland -- [Bentley, M. A. -- Bloor, D. -- Joshi, P. -- Wadsworth, R.] Univ York, Dept Phys, York YO10 5DD, N Yorkshire, England -- [Benzoni, G. -- Blasi, N. -- Boiano, C. -- Bracco, A. -- Brambilla, S. -- Camera, F. -- Capsoni, A. -- Casati, G. -- Coelli, S. -- Corsi, A. -- Cortesi, A. -- Crespi, F. C. L. -- Geraci, A. -- Giaz, A. -- Leoni, S. -- Million, B. -- Montanari, D. -- Nicolini, R. -- Pellegri, L. -- Pignanelli, M. -- Pullia, A. -- Riboldi, S. -- Ripamonti, G. -- Tomasi, F. -- Vandone, V. -- Viscione, E. -- Wieland, O. -- Zocca, F.] Ist Nazl Fis Nucl, Sez Milano, IT-20133 Milan, Italy -- [Berthier, R. -- Bouty, A. -- Broussard, S. -- Buerger, A. -- Drouen, Y. -- Gros, P. -- Goergen, A. -- Hervieu, B. -- Karolak, M. -- Kebbiri, M. -- Korten, W. -- Ljungvall, J. -- Lotode, A. -- Mariette, Y. -- Le Noa, Y. -- Obertelli, A. -- Le Pouhalec, P. -- Salsac, M. -D. -- Theisen, Ch. -- Touzery, R. -- Veyssiere, Ch.] CEA, Ctr Saclay, IRFU, F-91191 Gif Sur Yvette, France -- [Beunard, R. -- Bourgault, P. -- Cahan, B. -- Clement, E. -- de France, G. -- Legeard, L. -- Ozille, M. -- Pancin, J. -- Raine, R. -- Ropert, J. -A. -- Saillant, F. -- Tripon, M. -- Wittwer, G.] CEA DSM CNRS IN2P3, GANIL, F-14076 Caen, France -- [Birkenbach, B. -- Bruyneel, B. -- Eberth, J. -- Hess, H. -- Jolie, J. -- Lersch, D. -- Pascovici, G. -- Reiter, P. -- Warr, N. -- Weisshaar, D. -- Wiens, A.] Univ Cologne, IKP, D-50937 Cologne, Germany -- [Bizzeti, P. G. -- Bizzeti-Sona, A. M. -- Giannatiempo, A. -- Melon, B. -- Perego, A. -- Sona, P.] Univ Florence, Dipartimento Fis & Astron, IT-50019 Florence, Italy -- [Bizzeti, P. G. -- Bizzeti-Sona, A. M. -- Giannatiempo, A. -- Melon, B. -- Nannini, A. -- Perego, A. -- Sona, P.] Ist Nazl Fis Nucl, Sez Firenze, IT-50019 Florence, Italy -- [Blasco, J. M. -- Carrio, F. -- Egea, J. -- Gonzalez, V. -- Sanchis, E.] Univ Valencia, Dept Elect Engn, E-46100 Burjassot, Valencia, Spain -- [Borsato, M. -- Bortolato, D. -- Lenzi, S. M. -- Lunardi, S. -- Marginean, R. -- Mengoni, D. -- Michelagnoli, C. -- Nespolo, M. -- Recchia, F. -- Salvato, G. -- Triossi, A. -- Venturelli, R.] Univ Padua, Dipartimento Fis, IT-35131 Padua, Italy -- [Bracco, A. -- Camera, F. -- Corsi, A. -- Crespi, F. C. L. -- Giaz, A. -- Leoni, S. -- Montanari, D. -- Nicolini, R. -- Pellegri, L. -- Pignanelli, M. -- Pullia, A. -- Riboldi, S. -- Vandone, V.] Univ Milan, Dipartimento Fis, IT-20133 Milan, Italy -- [Brawn, I. P.] STFC Rutherford Appleton Lab, Didcot OX11 0QX, Oxon, England -- [Brondi, A. -- Moro, R. -- La Rana, G. -- Vardaci, E.] Univ Naples Federico II, Dipartimento Fis, IT-80126 Naples, Italy -- [Brondi, A. -- Moro, R. -- La Rana, G. -- Vardaci, E.] Ist Nazl Fis Nucl, Sez Napoli, IT-80126 Naples, Italy -- [Bucurescu, D. -- Marginean, N. -- Marginean, R. -- Petcu, M. -- Ur, C. A.] Natl Inst Phys & Nucl Engn, Bucharest, Romania -- [Buerger, A. -- Suliman, G. -- Zamfir, N. V.] Univ Bonn, Helmholtz Inst Strahlen & Kernphys, D-53115 Bonn, Germany -- [Buerger, A.] Univ Oslo, Dept Phys, N-0316 Oslo, Norway -- [Casati, G. -- Geraci, A. -- Ripamonti, G.] Politecn Milan, Dipartimento Elettron & Informaz, IT-20133 Milan, Italy -- [Castoldi, M. -- Zucchiatti, A.] Ist Nazl Fis Nucl, Sez Genova, IT-16146 Genoa, Italy -- [Chapman, R. -- Mengoni, D. -- Orlandi, R. -- Smith, J. F.] Univ W Scotland, Sch Engn, Paisley PA1 2BE, Renfrew, Scotland -- [Cullen, D. M. -- Robinson, A. P.] Univ Manchester, Sch Phys & Astron, Schuster Lab, Manchester M13 9PL, Lancs, England -- [Depalo, R.] Univ Padua, Dipartimento Astron, IT-35131 Padua, Italy -- [Descombes, T. -- Simpson, G.] Univ Grenoble 1, CNRS, IN2P3, LPSC,INP Grenoble, F-38026 Grenoble, France -- [Doncel, M. -- Hernandez-Prieto, A. -- Quintana, B.] Univ Salamanca, Dept Fis Fundamental, E-37008 Salamanca, Spain -- [Erduran, M. N. -- Ince, E.] Istanbul Univ, Istanbul, Turkey -- [Erturk, S.] Nigde Univ, Fac Sci, Dept Phys, TR-51200 Nigde, Turkey -- [Gast, W. -- Lieder, R. M. -- Mihailescu, L.] Forschungszentrum Julich, Inst Kernphys, D-52425 Julich, Germany -- [Gernhaeuser, R. -- Klupp, S. -- Kruecken, R. -- Schlarb, M.] Tech Univ Munich, Phys Dept E12, D-85748 Garching, Germany -- [Jaworski, G.] Warsaw Univ Technol, Fac Phys, PL-00662 Warsaw, Poland -- [Jaworski, G. -- Mierzejewski, J. -- Palacz, M.] Univ Warsaw, Heavy Ion Lab, PL-02093 Warsaw, Poland -- [Jones, P.] Univ Jyvaskyla, Dept Phys, FI-40014 Jyvaskyla, Finland -- [Jonson, B.] Chalmers, S-41296 Gothenburg, Sweden -- [Jungclaus, A. -- Orlandi, R.] CSIC, Inst Estruct Mat, E-28006 Madrid, Spain -- [Kempley, R. S. -- Podolyak, Z. -- Regan, P. H. -- Walker, P. M.] Univ Surrey, Dept Phys, Guildford GU2 7XH, Surrey, England -- [Mitev, K. -- Rainovski, G.] Sofia Univ St Kliment Ohridski, Fac Phys, Sofia, Bulgaria -- [Ozben, C.] Istanbul Tech Univ, TR-80626 Istanbul, Turkey -- [Rudolph, D.] Lund Univ, Dept Phys, SE-22100 Lund, Sweden, Research Group: Information Management, CSNSM SNO, Centre de Spectrométrie Nucléaire et de Spectrométrie de Masse (CSNSM), Université Paris-Sud - Paris 11 (UP11)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Université Paris-Sud - Paris 11 (UP11)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Centre de Sciences Nucléaires et de Sciences de la Matière (CSNSM), Université Paris-Sud - Paris 11 (UP11)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Institut de Physique Nucléaire d'Orsay (IPNO), informatique, Institut de Physique Nucléaire de Lyon (IPNL), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Institut Pluridisciplinaire Hubert Curien (IPHC), Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Grand Accélérateur National d'Ions Lourds (GANIL), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Département de Physique Nucléaire (ex SPhN) (DPHN), Institut de Recherches sur les lois Fondamentales de l'Univers (IRFU), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, CSNSM MECA, Université Paris-Sud - Paris 11 (UP11)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Université Paris-Sud - Paris 11 (UP11)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Physique Subatomique et de Cosmologie (LPSC), Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Institut Polytechnique de Grenoble - Grenoble Institute of Technology-Centre National de la Recherche Scientifique (CNRS), CSNSM INFOR, CSNSM ELEC, Matière Nucléaire, Institut de Physique des 2 Infinis de Lyon (IP2I Lyon), AGATA, Akkoyun, S., Algora, A., Alikhani, B., Ameil, F., De Angelis, G, Arnold, L., Astier, A., Ataç, A., Aubert, Y., Aufranc, C., Austin, A., Aydin, S., Azaiez, F., Badoer, S., Balabanski, D. L., Barrientos, D., Baulieu G., L, Baumann, R., Bazzacco, D., Beck, F. A., Beck, T., Bednarczyk, P., Bellato, M., Bentley, M. A., Benzoni, G., Berthier, R., Berti, L., Beunard, R., Lo Bianco, G., Birkenbach, B., Bizzeti, P. G., Bizzeti Sona, A. M., Le Blanc, F., Blasco, J. M., Blasi, N., Bloor, D., Boiano, C., Borsato, M., Bortolato, D., Boston, A. J., Boston, H. C., Bourgault, P., Boutachkov, P., Bouty, A., Bracco, A., Brambilla, S., Brawn, I. P., Brondi, Augusto, Broussard, S., Bruyneel, B., Bucurescu, D., Burrows, I., Bürger, A., Cabaret, S., Cahan, B., Calore, E., Camera, F., Capsoni, A., Carrió, F., Casati, G., Castoldi, M., Cederwall, B., Cercus J., L, Chambert, V., El Chambit, M., Chapman, R., Charles, L., Chavas, J., Clément, E., Cocconi, P., Coelli, S., Coleman Smith, P. J., Colombo, A., Colosimo, S., Commeaux, C., Conventi, D., Cooper, R. J., Corsi, A., Cortesi, A., Costa, L., Crespi, F. C. L., Cresswell, J. R., Cullen, D. M., Curien, D., Czermak, A., Delbourg, D., Depalo, R., Descombes, T., Désesquelles, P., Detistov, P., Diarra, C., Didierjean, F., Dimmock, M. R., Doan, Q. T., Domingo Pardo, C., Doncel, M., Dorangeville, F., Dosme, N., Drouen, Y., Duchêne, G., Dulny, B., Eberth, J., Edelbruck, P., Egea, J., Engert, T., Erduran, M. N., Ertürk, S., Fanin, C., Fantinel, S., Farnea, E., Faul, T., Filliger, M., Filmer, F., Finck, C., De France, G., Gadea, A., Gast, W., Geraci, A., Gerl, J., Gernhäuser, R., Giannatiempo, A., Giaz, A., Gibelin, L., Givechev, A., Goel, N., González, V., Gottardo, A., Grave, X., Grȩbosz, J., Griffiths, R., Grint, A. N., Gros, P., Guevara, L., Gulmini, M., Görgen, A., Ha, H. T. M., Habermann, T., Harkness, L. J., Harroch, H., Hauschild, K., He, C., Hernández Prieto, A., Hervieu, B., Hess, H., Hüyük, T., Ince, E., Isocrate, R., Jaworski, G., Johnson, A., Jolie, J., Jones, P., Jonson, B., Joshi, P., Judson, D. S., Jungclaus, A., Kaci, M., Karkour, N., Karolak, M., Kaşkaş, A., Kebbiri, M., Kempley, R. S., Khaplanov, A., Klupp, S., Kogimtzis, M., Kojouharov, I., Korichi, A., Korten, W., Kröll, T., Krücken, R., Kurz, N., Ky, B. Y., Labiche, M., Lafay, X., Lavergne, L., Lazarus, I. H., Leboutelier, S., Lefebvre, F., Legay, E., Legeard, L., Lelli, F., Lenzi, S. M., Leoni, S., Lermitage, A., Lersch, D., Leske, J., Letts, S. C., Lhenoret, S., Lieder, R. M., Linget, D., Ljungvall, J., Lopez Martens, A., Lotodé, A., Lunardi, S., Maj, A., Van Der Marel, J., Mariette, Y., Marginean, N., Marginean, R., Maron, G., Mather, A. R., Mȩczyński, W., Mendéz, V., Medina, P., Melon, B., Menegazzo, R., Mengoni, D., Merchan, E., Mihailescu, L., Michelagnoli, C., Mierzejewski, J., Milechina, L., Million, B., Mitev, K., Molini, P., Montanari, D., Moon, S., Morbiducci, F., Moro, RENATA EMILIA MARIA, Morrall, P. S., Möller, O., Nannini, A, Napoli, D. R., Nelson, L., Nespolo, M., Ngo, V. L., Nicoletto, M., Nicolini, R., Le Noa, Y., Nolan, P. J., Norman, M., Nyberg, J., Obertelli, A., Olariu, A., Orlandi, R., Oxley, D. C., Özben, C., Ozille, M., Oziol, C., Pachoud, E., Palacz, M., Palin, J., Pancin, J., Parisel, C., Pariset, P., Pascovici, G., Peghin, R., Pellegri, L., Perego, A., Perrier, S., Petcu, M., Petkov, P., Petrache, C., Pierre, E., Pietralla, N., Pietri, S., Pignanelli, M., Piqueras, I., Podolyak, Z., Le Pouhalec, P., Pouthas, J., Pugnére D., L, Pucknell, V. F. E., Pullia, A., Quintana, B., Raine, R., Rainovski, G., Ramina, L., Rampazzo, G., LA RANA, Giovanni, Rebeschini, M., Recchia, F., Redon N., L, Reese M., C, Reiter, P., Regan, P. H., Riboldi, S., Richer, M., Rigato, M., Rigby, S., Ripamonti, G., Robinson, A., Robin, J., Roccaz, J., Ropert, J. A., Rossé, B. l., Rossi Alvarez, C., Rosso, D., Rubio, B., Rudolph, D., Saillant, F., Şahin, E., Salomon, F., Salsac, M. D., Salt, J., Salvato, G., Sampson, J., Sanchis, E., Santos, C., Schaffner, H., Schlarb, M., Scraggs, D. P., Seddon, D., Şenyiǧit, M., Sigward, M. H., Simpson, G., Simpson, J., Slee, M., Smith, J. F., Sona, P., Sowicki, B., Spolaore, P., Stahl, C., Stanios, T., Stefanova, E., Stézowski, O., Strachan, J., Suliman, G., Söderström, P. A., Tain, J. L., Tanguy, S., Tashenov, S., Theisen, C. h., Thornhill, J., Tomasi, F., Toniolo, N., Touzery, R., Travers, B., Triossi, A., Tripon, M., Tun Lanoë, K. M. M., Turcato, M., Unsworth, C., Ur, C. A., Valiente Dobon, J. J., Vandone, V., Vardaci, Emanuele, Venturelli, R., Veronese, F., Veyssiere, C., Viscione, E., Wadsworth, R., Walker, P. M., Warr, N., Weber, C., Weisshaar, D., Wells, D., Wieland, O., Wiens A., U, Wittwer, G., Wollersheim, H. J., Zocca, F., Zamfir, N. V., Ziȩbliński, M., Zucchiatti, A., Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Sud - Paris 11 (UP11)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Sud - Paris 11 (UP11)-Centre de Sciences Nucléaires et de Sciences de la Matière (CSNSM), Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Sud - Paris 11 (UP11), Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Université de Strasbourg (UNISTRA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Sud - Paris 11 (UP11)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Sud - Paris 11 (UP11), Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut Polytechnique de Grenoble - Grenoble Institute of Technology-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Joseph Fourier - Grenoble 1 (UJF)-Centre National de la Recherche Scientifique (CNRS), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS), and 0-Belirlenecek
- Subjects
Nuclear and High Energy Physics ,Physics - Instrumentation and Detectors ,Pulse-shape and gamma-ray tracking algorithms ,FOS: Physical sciences ,Semiconductor detector performance and simulations ,Integrated circuit ,[PHYS.NEXP]Physics [physics]/Nuclear Experiment [nucl-ex] ,Tracking (particle physics) ,gamma-Ray tracking ,01 natural sciences ,Pulse-shape and γ-ray tracking algorithms ,law.invention ,Data acquisition ,law ,0103 physical sciences ,ddc:530 ,[PHYS.PHYS.PHYS-INS-DET]Physics [physics]/Physics [physics]/Instrumentation and Detectors [physics.ins-det] ,Nuclear Experiment (nucl-ex) ,010306 general physics ,γ-Ray spectroscopy ,Nuclear Experiment ,Instrumentation ,Digital signal processing ,Event reconstruction ,gamma-Ray spectroscopy ,Physics ,sezele ,Spectrometer ,Spectrometers ,010308 nuclear & particles physics ,business.industry ,Detector ,AGATA, Digital signals, HPGe detectors, Pulse-shape, Ray tracking ,HPGe detectors ,Algorithms, Crystals, Germanium, Semiconductor detectors, Signal processing, Spectrometry, Tracking (position) ,γ-Ray tracking ,Instrumentation and Detectors (physics.ins-det) ,AGATA ,Física nuclear ,business ,Computer hardware - Abstract
WOS: 000300864200005, The Advanced GAmma Tracking Array (AGATA) is a European project to develop and operate the next generation gamma-ray spectrometer. AGATA is based on the technique of gamma-ray energy tracking in electrically segmented high-purity germanium crystals. This technique requires the accurate determination of the energy, time and position of every interaction as a gamma ray deposits its energy within the detector volume. Reconstruction of the full interaction path results in a detector with very high efficiency and excellent spectral response. The realisation of gamma-ray tracking and AGATA is a result of many technical advances. These include the development of encapsulated highly segmented germanium detectors assembled in a triple cluster detector cryostat, an electronics system with fast digital sampling and a data acquisition system to process the data at a high rate. The full characterisation of the crystals was measured and compared with detector-response simulations. This enabled pulse-shape analysis algorithms, to extract energy, time and position, to be employed. In addition, tracking algorithms for event reconstruction were developed. The first phase of AGATA is now complete and operational in its first physics campaign. In the future AGATA will be moved between laboratories in Europe and operated in a series of campaigns to take advantage of the different beams and facilities available to maximise its science output. The paper reviews all the achievements made in the AGATA project including all the necessary infrastructure to operate and support the spectrometer. (C) 2011 Elsevier B.V. All rights reserved., EU [RII3-CT-2004-506065]; German BMBF [06K-167, 06KY2051]; Swedish Research Council; Knut and Alice Wallenberg Foundation; UK EPSRC Engineering and Physical Sciences Research Council; UK STFC Science and Technology Facilities Council; AWE plc; Scientific and Technological Research Council of Turkey [106T055]; Ankara University [05B4240002]; Polish Ministry of Science and Higher Education [DPN/N190/AGATA/2009]; Spanish MICINN [FPA2008-06419, FPA2009-13377-C02-02]; Spanish Consolider-Ingenio Programme CPAN [CSD2007-00042]; Generalitat Valenciana [PROMETEO/2010/101]; MICINN, Spain; INFN, Italy [AIC10-D-000568]; Science and Technology Facilities Council [ST/F012039/1, ST/J000094/1, ST/F004192/1, ST/J000159/1, ST/I504940/1, NuSTAR, ST/F006950/1, ST/I504916/1, ST/G000670/1, ST/F004060/1, ST/J000051/1, ST/J000108/1, ST/G000670/1 NuSTAR, ST/I504959/1, ST/G000727/1, ST/F004052/1, ST/F004184/1], AGATA and this work is supported by the European funding bodies and the EU Contract RII3-CT-2004-506065, the German BMBF under Grants 06K-167 and 06KY2051, the Swedish Research Council and the Knut and Alice Wallenberg Foundation, UK EPSRC Engineering and Physical Sciences Research Council, UK STFC Science and Technology Facilities Council, AWE plc, Scientific and Technological Research Council of Turkey (Proj. nr. 106T055) and Ankara University (BAP Proj. nr. 05B4240002), the Polish Ministry of Science and Higher Education under Grant DPN/N190/AGATA/2009, the Spanish MICINN under grants FPA2008-06419 and FPA2009-13377-C02-02, the Spanish Consolider-Ingenio 2010 Programme CPAN (contract number CSD2007-00042) the Generalitat Valenciana under Grant PROMETEO/2010/101, and research performed in the frame of the GSI-IN2P3 collaboration agreement number 02-42. A. Gadea and E. Farnea acknowledge the support of MICINN, Spain, and INFN, Italy, through the AIC10-D-000568 bilateral action.
- Published
- 2012
24. From Power-Localized to Extended Quasi-Energy Eigenstates in a Quantum Periodically Driven System
- Author
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C. R. de Oliveira, G. Casati, and I. Guarneri
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Nonlinear Sciences::Chaotic Dynamics ,Physics ,Delocalized electron ,Quantum mechanics ,Chaotic ,General Physics and Astronomy ,Monochromatic color ,Quantum ,Energy (signal processing) ,Eigenvalues and eigenvectors ,Classical limit ,Power (physics) - Abstract
We study the dynamics of a quantum particle in a triangular potential well under a monochromatic driving. We provide a purely quantal theory that accounts for the transition from localization to delocalization, without making reference to the chaotic transition occurring in the classical limit.
- Published
- 1994
25. Quantum Chaos: Degree of Reversibility of Quantum Dynamics of Classically Chaotic Systems
- Author
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G. Casati, Oleg V. Zhirov, Valentin V. Sokolov, and Giuliano Benenti
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Physics ,Quantum state ,Quantum mechanics ,Quantum dynamics ,Time evolution ,Wigner distribution function ,Quantum dissipation ,Quantum ,Classical limit ,Quantum chaos - Abstract
We present a quantitative analysis of the reversibility properties of classically chaotic quantum motion by relating the degree of reversibility to the rate at which a quantum state acquires a more and more complicated structure during its time evolution. This complexity can be characterized by the number M(t) of harmonics of the (initially isotropic, i.e. M(0) = 0) Wigner function, which are generated by the time t. We show that, in contrast to the classical exponential increase, this number can grow after the Ehrenfest time tE not faster than linearly. It follows that if the motion is reversed at some arbitrary moment T immediately after applying an instant perturbation with intensity described by the parameter ξ, then there exists a critical perturbation strength, ξc ≈ √ 2/M(T ), below which the initial state is well recovered, whereas reversibility disappears when ξ & ξc(T ). In the classical limit the number of harmonics proliferates exponentially with time and the motion becomes practically irreversible. The above results are illustrated in the example of the kicked quartic oscillator model.
- Published
- 2009
26. Novel human pathological mutations. Gene symbol: ALPL. Disease: hypophosphatasia
- Author
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Francesca, Bertola, C, Arosio, G, Casati, A, Piperno, F, Crosti, and C, Colombo
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Amino Acid Substitution ,Pregnancy ,Molecular Sequence Data ,Infant, Newborn ,Mutation, Missense ,Humans ,Hypophosphatasia ,Female ,Alkaline Phosphatase ,Codon - Published
- 2009
27. A demonstrator for an integrated subway protection system
- Author
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E. Detoma, G. Casati, P. Capetti, and S. Billington
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Identification (information) ,Engineering ,SCADA ,Containment ,business.industry ,Suite ,Systems engineering ,Train ,Dirty bomb ,Telecommunications ,business ,Track (rail transport) ,Metropolitan area - Abstract
In 2006 SEPA has carried on the installation and tests of a demonstrator for an integrated subway protection system at a new subway station in the Naples (Italy) metropolitan area. Protection of a subway system is a difficult task given the amount of passengers transported every day. The demonstrator has been limited to non-intrusive detection techniques not to impair the passenger flow into the station. The demonstrator integrates several technologies and products that have been developed by SEPA or are already available on the market (MKS Instruments, …). The main purpose is to provide detection capabilities for attempts to introduce radioactive substances in the subway station, in order to foil possible attempts to place a dirty bomb, and threat detection and identification following release of chemical agents. The system integrates additional sensors such as video surveillance cameras and air flow sensing to complement the basic sensors suite. The need to protect sensitive installations such as subway stations has been highlighted by the series of terroristics actions carried out in recent years in the subway in London. However, given the number of passengers of a metro system, it is impossible to propose security techniques operating in ways similar to the screening of passengers in airports. Passengers screening and threat detection and identification must be quick, non-intrusive and capable of screening a large number of passengers to be applicable to mass transit systems. In 2005 SEPA , a small company operating in the field of trains video-surveillance systems and radiation detectors, started developing an integrated system to provide a comprehensive protection to subway stations, based on ready available or off-the-shelf components in order to quickly develop a reliable system with available technology. We ruled out at the beginning any new development in order to speed up the fielding of the system in less than one year. The system was developed with commercial sensors and deployed in a new station of the Naples metropolitan transit system in Mugnano. The station was particularly suitable for the demonstration since it is a new station that includes air venting control, water barriers (for fire and smoke containment) and a complete SCADA system to integrate technical and video surveillance operations. In order to protect the subway, we tackled four basic technologies, all readily available in-house or on the market: • radiation detection, to detect the introduction in the station of radionuclides, that may be dispersed by conventional explosive (a “dirty” bomb); • chemical agents detection and identification (after release), complemented with air speed and velocity sensors to estimate, track and predict the contamination plume; • video surveillance, integrated with the SCADA system and already available in the station.
- Published
- 2008
28. Quantum Chaos: Degree of Reversibility of Quantum Dynamics of Classically Chaotic Sustems. Selected Papers from CHAOS 2008 International Conference
- Author
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V.V. Sokolov, O.V. Zhirov, G Benenti, and G. Casati
- Published
- 2008
- Full Text
- View/download PDF
29. Classical chaos, quantum localization and fluctuations: A unified view
- Author
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Dima L. Shepelyansky, G. Casati, and I. Guarneri
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Statistics and Probability ,Physics ,Mesoscopic physics ,Anderson localization ,Quantum dynamics ,Quantum mechanics ,Ionization ,Chaotic ,Statistical physics ,Condensed Matter Physics ,Quantum ,Anderson impurity model ,Excitation - Abstract
The localization phenomenon plays an essential role in the excitation of hydrogen atoms in microwave fields. The similarity of this phenomenon to Anderson localization, which has been established and discussed in previous papers, is here demonstrated in a transparent way by reducing the quantum dynamics to a one-dimensional pseudo-Anderson model. The effect of slight changes in the driving frequency on the ionization probability is numerically investigated on the quantum Kepler map; huge fluctuations are found, which persist down to a very fine frequency scale and have a qualitatively random nature. It is argued that such fluctuations are a counterpart of the mesoscopic fluctuations of solid-state physics, and that similar fluctuations should be expected any time, when some classical chaotic diffusive process is quantum-mechanically suppressed by dynamical localization.
- Published
- 1990
30. General Discussion on Molecular Rydberg States and Zeke Spectroscopy: Part I
- Author
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G. Casati
- Subjects
symbols.namesake ,Chemistry ,symbols ,Rydberg formula ,Atomic physics ,Hamiltonian (quantum mechanics) ,Spectroscopy - Published
- 2007
31. Quantum Information Theory
- Author
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Giuliano Benenti, Giuliano Strini, and G. Casati
- Subjects
Quantum technology ,Physics ,Open quantum system ,Quantum discord ,Quantum network ,Quantum mechanics ,Quantum process ,Quantum channel ,Quantum information ,Quantum information science - Published
- 2007
32. Quantum Error Correction
- Author
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Giuliano Strini, Giuliano Benenti, and G. Casati
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Physics ,Quantum error correction ,Quantum mechanics - Published
- 2007
33. First Experimental Implementations
- Author
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Giuliano Benenti, G. Casati, and Giuliano Strini
- Subjects
Computer science ,Parallel computing - Published
- 2007
34. Introduction to Quantum Mechanics
- Author
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G. Casati, Giuliano Benenti, and Giuliano Strini
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Physics ,Quantum technology ,medicine.medical_specialty ,Open quantum system ,Quantization (physics) ,Quantum dynamics ,Quantum mechanics ,Stochastic interpretation ,Quantum nanoscience ,medicine - Published
- 2004
35. Introduction to Classical Computation
- Author
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G. Casati, Giuliano Benenti, and Giuliano Strini
- Subjects
Computer science ,Computation ,Parallel computing - Published
- 2004
36. A pulse-shape analysis approach to 3-D position determination in large-volume segmented HPGe detectors
- Author
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G. Casati, Alberto Pullia, Giancarlo Ripamonti, Angelo Geraci, and E. Gatti
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Capacitive coupling ,Physics ,Optics ,Physics::Instrumentation and Detectors ,business.industry ,Position (vector) ,Detector ,Electrode ,Cluster (physics) ,Coaxial ,business ,Pulse shaping ,Pulse (physics) - Abstract
This paper is focused on the problem of the spatial localization of radiation-matter interaction in segmented large-volume HPGe detectors. The information is stored in the shapes of the current signals from the various segments. In order to design the algorithms, pulse shapes in a truly coaxial HPGe detector are calculated in closed form. Possible signatures dependent on a single interaction coordinate are found and a rough 3-D localization is obtained. The effects on pulse shapes of the detector encapsulating metallic cluster and of the gaps between sensing electrodes in terms of crosstalks due to capacitive coupling are also investigated.
- Published
- 2003
37. An algorithm for 3D localization of multiple pulses in large-volume segmented HPGe detectors
- Author
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Angelo Geraci, Giancarlo Ripamonti, F. Camera, G. Casati, Stefano Riboldi, E. Gatti, and B. Million
- Subjects
Physics ,Nuclear electronics ,Line (geometry) ,Bandwidth (signal processing) ,Ranging ,Focus (optics) ,Signal ,Algorithm ,Energy (signal processing) ,Communication channel - Abstract
We focus on the problem of the spatial localization of energy releasing events (hits) in segmented large-volume HPGe detectors. We present an algorithm for a precise radial coordinate estimation of events occurring at the same time in the same segment. The algorithm was designed bearing in mind that, with up to thousands of parallel channels, it is mandatory to perform the measurements in each channel with the least possible number of input data, while losing no important information and, possibly, operating on line in real time. For the sake of simulation, hits with energy ranging from 60 keV up to 2 MeV are taken into account and electronic noise and signal finite bandwidth effects are considered.
- Published
- 2002
38. Gamma-ray tracking with the MARS detector
- Author
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T. K. r. o. e. l. l., . D. Bazzacco, Venturelli, . R., Quintana Arnes, . B., C. A. U. r., . M. Bellato, R. I. s. o. c. r. a. t. e., . C. h. Manea, R. M. e. n. e. g. a. z. z. o., . P. Pavan, Rossi Alvarez, . C., E. F. a. r. n. e. a., . A. Gadea, D. R. o. s. s. o., . P. Spolaore, F. C. a. m. e. r. a., . B. Million, E. M. u. s. s. o., . A. Pullia, O. W. i. e. l. a. n. d., . G. Casati, Geraci, Angelo, and Ripamonti, Giancarlo
- Subjects
sezele - Published
- 2002
39. Fractal spin glass properties of low energy configurations in the Frenkel-Kontorova chain
- Author
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G. Casati, Oleg V. Zhirov, Dima L. Shepelyansky, Groupe de Physique Théorique (LPQ), Laboratoire de Physique Quantique (LPQ), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université Toulouse III - Paul Sabatier (UT3), and Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)
- Subjects
Physics ,Mechanical equilibrium ,Spin glass ,Condensed matter physics ,Phonon ,Condensed Matter (cond-mat) ,FOS: Physical sciences ,Condensed Matter ,01 natural sciences ,010305 fluids & plasmas ,3. Good health ,law.invention ,Fractal ,Chain (algebraic topology) ,law ,Phase (matter) ,[PHYS.COND.CM-GEN]Physics [physics]/Condensed Matter [cond-mat]/Other [cond-mat.other] ,0103 physical sciences ,010306 general physics ,Ground state ,Electronic band structure - Abstract
We study numerically and analytically the classical one-dimensional Frenkel-Kontorova chain in the regime of pinned phase characterized by phonon gap. Our results show the existence of exponentially many static equilibrium configurations which are exponentially close to the energy of the ground state. The energies of these configurations form a fractal quasi-degenerate band structure which is described on the basis of elementary excitations. Contrary to the ground state, the configurations inside these bands are disordered., Comment: revtex, 9 pages, 9 figures
- Published
- 2001
40. A semiquantal approach to finite systems of interacting particles
- Author
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Felix M. Izrailev, Giuseppe Luca Celardo, Fausto Borgonovi, and G. Casati
- Subjects
Physics ,Quantum Physics ,Spins ,Distribution (number theory) ,Nuclear Theory ,Condensed Matter (cond-mat) ,FOS: Physical sciences ,General Physics and Astronomy ,Function (mathematics) ,Condensed Matter ,Nonlinear Sciences - Chaotic Dynamics ,Symmetry (physics) ,Convolution ,Nuclear Theory (nucl-th) ,Classical mechanics ,Atomic orbital ,Quantum mechanics ,Chaotic Dynamics (nlin.CD) ,Quantum Physics (quant-ph) ,Quantum ,Eigenvalues and eigenvectors - Abstract
A novel approach is suggested for the statistical description of quantum systems of interacting particles. The key point of this approach is that a typical eigenstate in the energy representation (shape of eigenstates, SE) has a well defined classical analog which can be easily obtained from the classical equations of motion. Therefore, the occupation numbers for single-particle states can be represented as a convolution of the classical SE with the quantum occupation number operator for non-interacting particles. The latter takes into account the wavefunctions symmetry and depends on the unperturbed energy spectrum only. As a result, the distribution of occupation numbers $n_s$ can be numerically found for a very large number of interacting particles. Using the model of interacting spins we demonstrate that this approach gives a correct description of $n_s$ even in a deep quantum region with few single-particle orbitals., 4 pages, 2 figures
- Published
- 2001
41. Spatial localization of multiple simultaneous hits in segmented HPGe detectors: a new algorithm
- Author
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Angelo Geraci, G. Casati, E. Gatti, Stefano Riboldi, and Giancarlo Ripamonti
- Subjects
Physics ,Nuclear and High Energy Physics ,sezele ,Preamplifier ,Position (vector) ,Computation ,Bandwidth (signal processing) ,Detector ,Spatial localization ,Hpge detector ,Instrumentation ,Algorithm ,Semiconductor detector - Abstract
In this paper, we introduce a procedure aimed at measuring the position of charge releasing events within a segmented HPGe γ-ray detector. The proposed method is able to easily discriminate multiple events occurring close in space, even within the same segment. This is crucial in most applications. Limiting factors for the procedure, such as electronic noise and the finite bandwidth of the preamplifier are also considered, their effects modeled and taken into account. The algorithm is not computation intensive and it is meant for real time operation on a simple dedicated hardware.
- Published
- 2001
42. Regular and Anomalous Quantum Diffusion in the Fibonacci Kicked Rotator
- Author
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Giorgio Mantica, G. Casati, and Dima L. Shepelyansky
- Subjects
Physics ,Fibonacci number ,Condensed Matter (cond-mat) ,Quasicrystal ,FOS: Physical sciences ,Condensed Matter ,Quantum chaos ,Nonlinear Sciences::Chaotic Dynamics ,Classical mechanics ,Quantum mechanics ,Exponent ,Physics::Accelerator Physics ,Diffusion (business) ,Kicked rotator ,Quantum ,Excitation - Abstract
We study the dynamics of a quantum rotator kicked according to the almost-periodic Fibonacci sequence. A special numerical technique allows us to carry on this investigation for as many as $10^{12}$ kicks. It is shown that above a critical kick strength the excitation of the system is well described by regular diffusion, while below this border it becomes anomalous, and sub-diffusive. A law for the dependence of the exponent of anomalous sub-diffusion on the system parameters is established numerically. The analogy between these results and quantum diffusion in models of quasi-crystal and in the kicked Harper system is discussed., 7 pages, 4 figures, submitted to Phys. Rev. E
- Published
- 2000
43. Lack of effect of hexarelin on TRH-induced TSH response in normal adult man
- Author
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Giovanni Faglia, S. Porretti, B. P. Imbimbo, Maura Arosio, O. Biella, and G. Casati
- Subjects
Adult ,Male ,endocrine system ,medicine.medical_specialty ,endocrine system diseases ,Hydrocortisone ,Somatostatin secretion ,Endocrinology, Diabetes and Metabolism ,Thyrotropin ,Peptide hormone ,Placebo ,Endocrinology ,TRH stimulation test ,Internal medicine ,Blood plasma ,medicine ,Humans ,Growth Substances ,Thyrotropin-Releasing Hormone ,business.industry ,Human Growth Hormone ,Prolactin ,Kinetics ,Somatostatin ,Mechanism of action ,Female ,medicine.symptom ,business ,Oligopeptides ,hormones, hormone substitutes, and hormone antagonists ,Hormone - Abstract
The mechanism of action of the synthetic growth hormone (GH)releasing peptide hexarelin is not yet fully understood. Although a direct effect on pituitary cells has been demonstrated, the peptide is also active at hypothalamic level, where specific binding sites have been found. The observation that hexarelin acts synergistically with GH-releasing hormone (GHRH) in releasing GH has suggested that it might suppress endogenous somatostatin secretion. As somatostatin is also inhibitory on TSH secretion, to verify the occurrence of modifications of the somatostatinergic tone induced by hexarelin, we studied its effects on TRH-induced TSH secretion. Seven normal subjects (4 women and 3 men aged 24-29 years) underwent the following tests on 3 different days: a) TRH (200 micrograms/l i.v.) + placebo; b) hexarelin (1 microgram/Kg bw i.v.) + placebo c) combined TRH + hexarelin administration. Hexarelin induced significant and similar increases in serum GH levels when given in combination either with placebo or with TRH (1217 +/- 470 vs 986 +/- 208 micrograms/min/l p:NS), while no modifications of GH levels were seen after TRH + placebo. Serum TSH levels were unmodified by hexarelin + placebo injection. The TSH increase elicited by hexarelin + TRH was superimposable to that elicited by TRH + placebo (1124 +/- 530 and 1273 +/- 380 mU/min/l respectively). Circulating PRL levels slightly increased after hexarelin + placebo too (897 micrograms/min/l), and the PRL response to hexarelin + TRH was slightly, although not significantly, greater than that observed after TRH + placebo (2680 +/- 1517 and 2243 +/- 1108 micrograms/min/l, respectively). In conclusion, our data show that hexarelin does not alter basal and TRH-stimulated TSH secretion, thus suggesting that it does not inhibit somatostatin release. Furthermore a modest PRL-releasing effect of this peptide has been confirmed.
- Published
- 1998
44. 662 Heterogeneity of iron overload: Clinical, biochemical, histopathologic and genetic study of 70 patients
- Author
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G. Casati, Alessandra Salvioni, P. Trombini, Anna Vergani, Sara Pelucchi, Giorgio Bovo, Silvia Fargion, Alberto Piperno, Alessia Riva, and R. Mariani
- Subjects
Hepatology - Published
- 2006
45. Effects of treatment with octreotide in acromegalic patients--a multicenter Italian study. Italian Multicenter Octreotide Study Group
- Author
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M, Arosio, S, Macchelli, C M, Rossi, G, Casati, O, Biella, and G, Faglia
- Subjects
Adenoma ,Adult ,Blood Glucose ,Male ,Thyroid Gland ,Glucose Tolerance Test ,Middle Aged ,Octreotide ,Prolactin ,Diabetes Complications ,Gonadotropin-Releasing Hormone ,Italy ,Growth Hormone ,Acromegaly ,Diabetes Mellitus ,Humans ,Insulin ,Female ,Pituitary Neoplasms ,Prospective Studies ,Insulin-Like Growth Factor I ,Thyrotropin-Releasing Hormone ,Ultrasonography - Abstract
Treatment of acromegaly is effective in reversing the reduced life-span of patients only when serum growth hormone (GH) concentrations are lowered to less than 2.5 micrograms/l. Usual treatments achieve this goal in no more than 50-60% of patients. The effects of octreotide were studied in a prospective, open label study with 68 acromegalic patients enrolled in 10 Italian centers. Octreotide was administered sc at a dose of 100 micrograms t.i.d. for 1 year. After 3 months of therapy, octreotide was effective in decreasing serum GH levels below 2.5 micrograms/l in 16 out of 64 acromegalic patients (25%). Fifteen of them had pretreatment GH levels below 25 micrograms/l. Insulin-like growth factor I (IGF-I) levels normalized in about 40% of patients. No further GH reduction was observed after 1 year of treatment. The presence of abnormal GH responses to thyrotropin-releasing hormone (TRH) and gonadotropin-releasing hormone was reduced from 54 to 24% and from 16 to 12%, respectively. Tumor shrinkage was observed in 50% of 26 non-irradiated patients after 12 months of treatment. Both basal and TRH-stimulated serum prolactin levels significantly decreased in the 11 hyperprolactinemic patients. Although serum thyrotropin, free triiodothyronine and free thyroxine concentrations were not modified, a significant reduction of thyrotropin response to TRH was observed in the 9th month of therapy. In non-diabetic patients, an increase of mean blood glucose levels without modifications of fasting morning concentrations was found. About one-quarter of the patients with overt diabetes mellitus had an impairment of their metabolic control. Main clinical symptoms of acromegaly improved in 70-80% of patients.(ABSTRACT TRUNCATED AT 250 WORDS)
- Published
- 1995
46. [Effect of GH/IGF-I deficiency on bone and collagen turnover in children and adults with GH deficiency]
- Author
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A, Sartorio, A, Conti, M, Monzani, S, Ferrero, O, Biella, G, Casati, and G, Faglia
- Subjects
Adult ,Male ,Adolescent ,Osteocalcin ,Middle Aged ,Collagen Type I ,Peptide Fragments ,Growth Hormone ,Humans ,Female ,Bone Remodeling ,Collagen ,Child ,Peptides ,Biomarkers ,Procollagen - Abstract
Serum bone Gla protein (BGP), marker of osteoblastic function, carboxyterminal cross-linked telopeptide of type I collagen (ICTP), index of bone resorption, and aminoterminal propeptide of type III procollagen, marker of collagen synthesis, were evaluated in children with GH deficiency (GHD), in adults with childhood-onset GHD and in adults with acquired GHD in adultlife. In children with GHD, serum BGP (12.7 +/- 0.5 ng/ml), ICTP (8.5 +/- 0.9 ng/ml) and PIIINP (3.4 +/- 0.4 ng/ml) were significantly lower (p0.0001, p0.0001 and p0.001, respectively) than those observed in a sex and age matched control group (BGP:18.9 +/- 0.9 ng/ml, ICTP: 14.4 +/- 0.6 ng/ml, PIIINP: 6.7 +/- 0.7 ng/ml). In adults with childhood onsed GHD, BGP levels (3.7 +/- 0.4 ng/ml) were significantly lower (p0.0001) than those recorded in a sex and age matched control group (5.4 +/- 0.1 ng/ml), while ICTP (4.7 +/- 0.7 ng/ml) and PIIINP (3.7 +/- 0.5 ng/ml) levels were similar to those found in controls (ICTP: 4.1 +/- 0.3 ng/ml; PIIINP: 3.3 +/- 0.2 ng/ml). In adults with acquired GHD, serum BGP (5.3 +/- 0.4 ng/ml), ICTP (3.8 +/- 0.4 ng/ml) and PIIINP (3.6 +/- 0.3 ng/ml) levels were not significantly different from those recorded in controls (BGP: 5.4 +/- 0.1 ng/ml, ICTP: 4.1 +/- 0.3 ng/ml, PIIINP: 3.3 +/- 0.2 ng/ml).(ABSTRACT TRUNCATED AT 250 WORDS)
- Published
- 1995
47. Thermodynamic analysis of the spectral measure for kicked quantum systems
- Author
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D. Belluzzo, G. Casati, and Roberto Artuso
- Subjects
Physics ,Formalism (philosophy of mathematics) ,Theoretical physics ,Dynamical systems theory ,Chaotic systems ,Autocorrelation ,Quantum system ,General Physics and Astronomy ,Statistical physics ,Quantum ,Spectral measure ,Quantum chaos - Abstract
Recent studies have revealed the occurrence of rich spectral structures in quantum systems whose classical analogues are two-dimensional area-preserving maps. We show how the spectral measure can be conveniently investigated by means of the thermodynamic formalism.
- Published
- 1994
48. Wigner’s semicircle law for band random matrices
- Author
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V. Girko and G. Casati
- Subjects
Statistics and Probability ,Statistical physics ,Wigner semicircle distribution ,Semicircle law ,Random matrix ,Analysis ,Mathematics ,Mathematical physics - Published
- 1993
49. Preface
- Author
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G. CASATI, I. GUARNERI, V. MANFREDI, and U. SMILANSKY
- Published
- 1993
50. Quantum Computers, Algorithms and Chaos
- Author
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G. Casati, D.L. Shepelyansky, P. Zoller, G. Casati, D.L. Shepelyansky, and P. Zoller
- Subjects
- Quantum computers--Congresses, Quantum chaos--Congresses
- Abstract
During the last ten years Quantum Information Processing and Communication (QIPC) has established itself as one of the new hot topic fields in physics, with the potential to revolutionize many areas of science and technology. QIPC replaces the laws of classical physics applied to computation and communication with the more fundamental laws of quantum mechanics. This becomes increasingly important due to technological progress going down to smaller and smaller scales where quantum effects start to be dominant. In addition to its fundamental nature, QIPC promises to advance computing power beyond the capabilities of any classical computer, to guarantee secure communication and establish direct links to emerging quantum technologies, such as, for example, quantum based sensors and clocks. One of the outstanding feature of QIPC is its interdisciplinary character: it brings together researchers from physics, mathematics and computer science. In particular, within physics we have seen the emergence of a new QIPC community, which ranges from theoretical to experimental physics, and crosses boundaries of traditionally separated disciplines such as atomic physics, quantum optics, statistical mechanics and solid state physics, all working on different and complementary aspects of QIPC. This publication covers the following topics: Introduction to quantum computing; Quantum logic, information and entanglement; Quantum algorithms; Error-correcting codes for quantum computations; Quantum measurements and control; Quantum communication; Quantum optics and cold atoms for quantum information; Quantum computing with solid state devices; Theory and experiments for superconducting qubits; Interactions in many-body systems: quantum chaos, disorder and random matrices; Decoherence effects for quantum computing; and Flature prospects of quantum information processing.
- Published
- 2006
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