2,516 results on '"Frigerio, C"'
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2. Sentenza 26 marzo 1969, n. 45 (Gazzetta ufficiale 2 aprile 1969, n. 85); Pres. Sandulli P., Rel. Bonifacio; Lo Monaco c. Interlandi; Bertocchi (Avv. B. Gallo) c. Traina (Avv. M. S. Giannini, Franco); Dolci c. Bellino; Ameghino (Avv. Mancini) c. Iannitto (Avv. Della Pietra); Roscica c. Caronia; Gigliarelli c. Cosmi; Frigerio c. Santambrogio; Serra c. Brasile; Gini c. Mancini (Avv. Acquaroli); Samoggia c. Barbieri; Gasparini c. Rossi
- Author
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Caretti, Paolo
- Published
- 1969
3. Sezione I civile; sentenza 10 agosto 1962, n. 2524; Pres. Lonardo P., Est. Giannattasio, P. M. Trotta (concl. diff.); S.a.m.e. (Avv. Di Roberto, Clerici, Frigerio) c. Credito commerciale (Avv. Silvestri, Segrè)
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- 1962
4. Sentenza 30 gennaio 1970; Pres. Massari P., Est. Lo Turco; Frigerio c. Vitaloni
- Published
- 1970
5. Sezione III civile; sentenza 28 aprile 1956, n. 1330; Pres. Zappulli P., Est. Laporta, P. M. Caldarera (concl. diff.); Gregoric (Avv. Cuciniello, Frigerio) c. Barberio (Avv. Soddu)
- Published
- 1957
6. Udienza 28 dicembre 1926; Pres. ed est. Ranelletti; Leoni (Avv. Frigerio) c. Soc. An. Lavanderia a vapore (Avv. Momigliano)
- Published
- 1927
7. Variable fault tip propagation rates affected by near-surface lithology and implications for fault displacement hazard assessment
- Author
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Livio, F.A., Ferrario, M.F., Frigerio, C., Zerboni, A., and Michetti, A.M.
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- 2020
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8. SURVEY OF AIFM BRACHIT WORK GROUP ON BRACHYTHERAPY PRACTICE IN ITALY
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Rinaldin, G., primary, Bianchi, C., additional, Frigerio, C., additional, and Ghedi, B., additional
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- 2023
- Full Text
- View/download PDF
9. Severe Acute Respiratory Syndrome Coronavirus 2 and Medical Evacuation in Lombardy: Lessons Learned from an Unprecedented Pandemic
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Stucchi, R, Ripoll-Gallardo, A, Sechi, G, Weinstein, E, Villa, G, Frigerio, C, Federighi, F, Grasselli, G, Zoli, A, Bonora, R, Fumagalli, R, Stucchi R., Ripoll-Gallardo A., Sechi G. M., Weinstein E. S., Villa G. F., Frigerio C., Federighi F., Grasselli G., Zoli A., Bonora R., Fumagalli R., Stucchi, R, Ripoll-Gallardo, A, Sechi, G, Weinstein, E, Villa, G, Frigerio, C, Federighi, F, Grasselli, G, Zoli, A, Bonora, R, Fumagalli, R, Stucchi R., Ripoll-Gallardo A., Sechi G. M., Weinstein E. S., Villa G. F., Frigerio C., Federighi F., Grasselli G., Zoli A., Bonora R., and Fumagalli R.
- Abstract
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerging infectious disease pandemic developed in Lombardy (northern Italy) during the last week of February 2020 with a progressive increase of patients presenting with serious clinical findings. Despite the efforts of the Central Italian Government, regional resources were rapidly at capacity. The solution was to plan the medical evacuation (MEDEVAC) of 119 critically ill patients (median age 61 years) to in-patient intensive care units in other Italian regions (77) and Germany (42). Once surviving patients were deemed suitable, the repatriation process concluded the assignment. The aim of this report is to underline the importance of a rapid organization and coordination process between different nodes of an effective national and international network during an emerging infectious disease outbreak and draw lessons learned from similar published reports.
- Published
- 2023
10. Exploring the interconnections between DNA-RNA hybrids and the DNA damage response
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Frigerio, C, Galli, M, Clerici, M, Bonetti, D, Frigerio, C., Galli, M., Clerici, M., Bonetti, D., Frigerio, C, Galli, M, Clerici, M, Bonetti, D, Frigerio, C., Galli, M., Clerici, M., and Bonetti, D.
- Published
- 2023
11. Selective suppression of oligodendrocyte-derived amyloid beta rescues neuronal dysfunction in Alzheimer's disease.
- Author
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Rajani RM, Ellingford R, Hellmuth M, Harris SS, Taso OS, Graykowski D, Lam FKW, Arber C, Fertan E, Danial JSH, Swire M, Lloyd M, Giovannucci TA, Bourdenx M, Klenerman D, Vassar R, Wray S, Sala Frigerio C, and Busche MA
- Subjects
- Animals, Female, Humans, Male, Mice, Brain metabolism, Brain pathology, Gene Knock-In Techniques, Alzheimer Disease metabolism, Alzheimer Disease pathology, Alzheimer Disease genetics, Amyloid beta-Peptides metabolism, Disease Models, Animal, Mice, Transgenic, Neurons metabolism, Oligodendroglia metabolism
- Abstract
Reduction of amyloid beta (Aβ) has been shown to be effective in treating Alzheimer's disease (AD), but the underlying assumption that neurons are the main source of pathogenic Aβ is untested. Here, we challenge this prevailing belief by demonstrating that oligodendrocytes are an important source of Aβ in the human brain and play a key role in promoting abnormal neuronal hyperactivity in an AD knock-in mouse model. We show that selectively suppressing oligodendrocyte Aβ production improves AD brain pathology and restores neuronal function in the mouse model in vivo. Our findings suggest that targeting oligodendrocyte Aβ production could be a promising therapeutic strategy for treating AD., Competing Interests: C.S.F. is currently employed by GSK. The other authors have declared that no competing interests exist., (Copyright: © 2024 Rajani et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.)
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- 2024
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12. Exo1 cooperates with Tel1/ATM in promoting recombination events at DNA replication forks.
- Author
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Galli M, Frigerio C, Colombo CV, Casari E, Longhese MP, and Clerici M
- Abstract
Tel1/ataxia telangiectasia mutated (ATM) kinase plays multiple functions in response to DNA damage, promoting checkpoint-mediated cell-cycle arrest and repair of broken DNA. In addition, Saccharomyces cerevisiae Tel1 stabilizes replication forks that arrest upon the treatment with the topoisomerase poison camptothecin (CPT). We discover that inactivation of the Exo1 nuclease exacerbates the sensitivity of Tel1-deficient cells to CPT and other agents that hamper DNA replication. Furthermore, cells lacking both Exo1 and Tel1 activities exhibit sustained checkpoint activation in the presence of CPT, indicating that Tel1 and Exo1 limit the activation of a Mec1-dependent checkpoint. The absence of Tel1 or its kinase activity enhances recombination between inverted DNA repeats induced by replication fork blockage in an Exo1-dependent manner. Thus, we propose that Exo1 processes intermediates arising at stalled forks in tel1 mutants to promote DNA replication recovery and cell survival., Competing Interests: The authors declare no competing interests., (© 2024 The Authors.)
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- 2024
- Full Text
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13. Relevance of TSH evaluation in elderly in-patients with non-thyroidal illness
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Rosenfarb, J., Sforza, N., Rujelman, R., Morosan Allo, Y., Parisi, C., Blanc, E., Frigerio, C., Fossati, P., Caruso, D., Faingold, C., Meroño, T., and Brenta, G.
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- 2019
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14. First evidence for Late Pleistocene to Holocene earthquake surface faulting in the Eastern Monferrato Arc (Northern Italy): Geology, pedostratigraphy and structural study of the Pecetto di Valenza site
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Frigerio, C., Bonadeo, L., Zerboni, A., Livio, F., Ferrario, M.F., Fioraso, G., Irace, A., Brunamonte, F., and Michetti, A.M.
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- 2017
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15. Prognostic Role of Basal Serum Alpha-Fetoprotein in Patients with Hepatocellular Carcinoma Suitable for Curative Treatment.
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Mazza S, Frigerio C, Alfieri D, Mauro A, Torello Viera F, Scalvini D, Barteselli C, Sgarlata C, Veronese L, Bardone M, Rovedatti L, Agazzi S, Strada E, Pozzi L, Maestri M, Ravetta V, and Anderloni A
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- Humans, Male, Female, Middle Aged, Retrospective Studies, Prognosis, Aged, Biomarkers, Tumor blood, Adult, Proportional Hazards Models, Survival Analysis, Carcinoma, Hepatocellular blood, alpha-Fetoproteins analysis, Liver Neoplasms blood
- Abstract
Background and Objectives : Serum alpha-fetoprotein (AFP) is a recognized affordable oncological marker in patients with hepatocellular carcinoma (HCC). However, AFP's prognostic role has been assessed mainly after specific treatments, and no unanimously recognized cut-offs have been identified. The aim of this study is to investigate the prognostic role of different basal AFP cut-offs on survival and HCC course. Materials and Methods : In this single-center, retrospective study, all patients newly diagnosed with HCC between January 2009 and December 2021 were prospectively enrolled. Only patients suitable for curative HCC treatments were included in the analyses. Patients were stratified according to AFP cut-offs of 20, 200, 400, and 1000 ng/mL, which were correlated with survival outcomes and clinical parameters. Results : A total of 266 patients were analyzed, with a median follow-up time of 41.5 months. Median overall survival (OS) of all cohort was 43 months. At the multivariate Cox-regression analysis, AFP value ≥ 1000 ng/mL correlated with impaired OS (1-year OS: 67% vs. 88%, 5-year OS: 1% vs. 43%; p = 0.005); other risk factors were tumor dimension ≥ 5 cm (HR 1.73; p = 0.002), Child-Pugh class B-C (HR 1.72; p = 0.002), BCLC stage A (vs. 0) (HR 2.4; p = 0.011), and malignant portal vein thrombosis (HR 2.57; p = 0.007). AFP ≥ 1000 ng/mL was also associated with a reduced recurrence-free survival (HR 2.0; p = 0.038), while starting from AFP ≥ 20 ng/mL, a correlation with development of HCC metastases over time (HR 3.5; p = 0.002) was seen. AFP values ≥ 20 ng/mL significantly correlated with tumor size and higher histological grading; starting from AFP values ≥ 400 ng/mL, a significant correlation with Child-Pugh class B-C and female gender was also observed. Conclusions : Basal AFP correlates with relevant outcomes in patients with HCC. It could help identify patients at a higher risk of worse prognosis who might benefit from personalized surveillance and treatment programs. Prospective studies are needed to confirm these results.
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- 2024
- Full Text
- View/download PDF
16. PC-01.20 - SURVEY OF AIFM BRACHIT WORK GROUP ON BRACHYTHERAPY PRACTICE IN ITALY
- Author
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Rinaldin, G., Bianchi, C., Frigerio, C., and Ghedi, B.
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- 2023
- Full Text
- View/download PDF
17. The Chromatin Landscape around DNA Double-Strand Breaks in Yeast and Its Influence on DNA Repair Pathway Choice
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Frigerio, C, Di Nisio, E, Galli, M, Colombo, C, Negri, R, Clerici, M, Colombo, CV, Frigerio, C, Di Nisio, E, Galli, M, Colombo, C, Negri, R, Clerici, M, and Colombo, CV
- Abstract
DNA double-strand breaks (DSBs) are harmful DNA lesions, which elicit catastrophic consequences for genome stability if not properly repaired. DSBs can be repaired by either non-homologous end joining (NHEJ) or homologous recombination (HR). The choice between these two pathways depends on which proteins bind to the DSB ends and how their action is regulated. NHEJ initiates with the binding of the Ku complex to the DNA ends, while HR is initiated by the nucleolytic degradation of the 5′-ended DNA strands, which requires several DNA nucleases/helicases and generates single-stranded DNA overhangs. DSB repair occurs within a precisely organized chromatin environment, where the DNA is wrapped around histone octamers to form the nucleosomes. Nucleosomes impose a barrier to the DNA end processing and repair machinery. Chromatin organization around a DSB is modified to allow proper DSB repair either by the removal of entire nucleosomes, thanks to the action of chromatin remodeling factors, or by post-translational modifications of histones, thus increasing chromatin flexibility and the accessibility of repair enzymes to the DNA. Here, we review histone post-translational modifications occurring around a DSB in the yeast Saccharomyces cerevisiae and their role in DSB repair, with particular attention to DSB repair pathway choice.
- Published
- 2023
18. Seasonality fluctuations recorded in fossil bivalves during the early Pleistocene: Implications for climate change
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Crippa, Gaia, Angiolini, L., Bottini, C., Erba, E., Felletti, F., Frigerio, C., Hennissen, J.A.I., Leng, M.J., Petrizzo, M.R., Raffi, I., Raineri, G., and Stephenson, M.H.
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- 2016
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19. Hypothyroidism in hospitalized elderly patients: a sign of worse prognosis
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Sforza, N., Rosenfarb, J., Rujelman, R., Rosmarin, M., Blanc, E., Frigerio, C., Fossati, P., Caruso, D., Faingold, C., Meroño, T., and Brenta, G.
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- 2017
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20. Ultrasound Patterns of Hepatocellular Carcinoma and Their Prognostic Impact: A Retrospective Study.
- Author
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Barteselli C, Mazza S, Ravetta V, Viera FT, Veronese L, Frigerio C, Gori G, Bergamaschi G, Sgarlata C, Facciorusso A, Maestri M, Di Sabatino A, and Anderloni A
- Abstract
Background: Hepatocellular carcinoma (HCC) is a leading cause of cancer-related death. Abdominal ultrasound (US) is by far the most widely used first-level exam for the diagnosis of HCC. We aimed to assess whether different ultrasound patterns were related to tumor prognosis., Methods: We retrospectively reviewed all patients with a new diagnosis of HCC (single nodule) and undergoing radiofrequency thermal ablation (RFTA) at our clinic between January 2009 and December 2021. Patients were classified according to four HCC ultrasound patterns: 1A, single capsulated nodule; 1B, well capsulated intra-node nodule; 1C, cluster consisting of capsulated nodules; and 2, non-capsulated nodule., Results: 149 patients were analysed; median follow-up time was 43 months. US patterns 1A (32.9%) and 1B (61.1%) were the most commonly seen. Median overall survival (OS) and recurrence-free survival (RFS) from RFTA were 54 months (95% CI, 42-66) and 22 months (95% CI, 12-32), respectively. Pattern 1A showed the best OS. Compared to pattern 1A, 1B was independently associated with worse OS (51 months (95% CI, 34-68) vs. 46 months (95% CI, 18-62)) and RFS (34 months (95% CI, 27-41) vs. 18 months (95% CI, 12-24)). Patterns 1C and 2 were associated with worse RFS compared to 1A, while no difference was seen for OS. Among baseline clinical variables, pattern 1B exhibited higher histological grade ( p = 0.048) and tumor dimension ( p = 0.034) compared to pattern 1A., Conclusions: Our findings demonstrate that different US patterns correlate with different survival outcomes and tumor behavior in patients with HCC. Prospective studies are needed to confirm these results.
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- 2023
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21. Perivascular cells induce microglial phagocytic states and synaptic engulfment via SPP1 in mouse models of Alzheimer's disease.
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De Schepper S, Ge JZ, Crowley G, Ferreira LSS, Garceau D, Toomey CE, Sokolova D, Rueda-Carrasco J, Shin SH, Kim JS, Childs T, Lashley T, Burden JJ, Sasner M, Sala Frigerio C, Jung S, and Hong S
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- Mice, Animals, Microglia metabolism, Osteopontin metabolism, Phagocytes metabolism, Macrophages metabolism, Phagocytosis, Disease Models, Animal, Amyloid beta-Peptides metabolism, Alzheimer Disease metabolism
- Abstract
Alzheimer's disease (AD) is characterized by synaptic loss, which can result from dysfunctional microglial phagocytosis and complement activation. However, what signals drive aberrant microglia-mediated engulfment of synapses in AD is unclear. Here we report that secreted phosphoprotein 1 (SPP1/osteopontin) is upregulated predominantly by perivascular macrophages and, to a lesser extent, by perivascular fibroblasts. Perivascular SPP1 is required for microglia to engulf synapses and upregulate phagocytic markers including C1qa, Grn and Ctsb in presence of amyloid-β oligomers. Absence of Spp1 expression in AD mouse models results in prevention of synaptic loss. Furthermore, single-cell RNA sequencing and putative cell-cell interaction analyses reveal that perivascular SPP1 induces microglial phagocytic states in the hippocampus of a mouse model of AD. Altogether, we suggest a functional role for SPP1 in perivascular cells-to-microglia crosstalk, whereby SPP1 modulates microglia-mediated synaptic engulfment in mouse models of AD., (© 2023. The Author(s).)
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- 2023
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22. High-dose-rate brachytherapy as monotherapy for localized prostate cancer using three different doses - 14 years of single-centre experience
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Soatti, C, Delishaj, D, D'Amico, R, Frigerio, C, Fumagalli, I, Bonsignore, F, Sangalli, G, Declich, F, Arcangeli, S, Ardizzoia, A, Colombo, A, Soatti C. P., Delishaj D., D'Amico R., Frigerio C., Fumagalli I. C., Bonsignore F., Sangalli G., Declich F., Arcangeli S., Ardizzoia A., Colombo A., Soatti, C, Delishaj, D, D'Amico, R, Frigerio, C, Fumagalli, I, Bonsignore, F, Sangalli, G, Declich, F, Arcangeli, S, Ardizzoia, A, Colombo, A, Soatti C. P., Delishaj D., D'Amico R., Frigerio C., Fumagalli I. C., Bonsignore F., Sangalli G., Declich F., Arcangeli S., Ardizzoia A., and Colombo A.
- Abstract
Purpose: To evaluate clinical outcomes in patients with localized prostate cancer (LPC) treated with 3D conformal high-dose-rate (HDR) brachytherapy (BT) as monotherapy. Material and methods: From March 2004 to November 2017, 277 men with LPC underwent 3D conformal HDR-BT as monotherapy, with a temporary implant. The dose prescription was: 38 Gy in 4 fractions (149 patients), 27 Gy in 2 fractions (41 patients), and 19-20 Gy in a single fraction (87 patients). Biochemical progression-free survival (bPFS), progression- free survival (PFS), and cancer-specific survival (CSS) were calculated. Acute and late genitourinary (GU) and gastrointestinal (GI) toxicity assessment were performed using Common Terminology Criteria for Adverse Events v5.0. Results: The mean age was 67 (range, 47-81) years. Overall, 145 patients were low-risk, 116 intermediate-risk, and 16 high-risk prostate cancer. After a median follow-up of six years (range, 6-160 months), bPFS, PFS, and CSS were 81%, 96%, and 97%, respectively. Dose prescription, initial prostate specific antigen (iPSA) ≥ 9,5 ng/ml, and high-risk disease resulted in prognostic factors regarding bPFS. Only G2-G3 acute or late GI and GU toxicities were observed. Conclusions: HDR-BT as monotherapy is a valid and safe treatment modality for localized prostate cancer. After a long follow-up, patients receiving 19-20 Gy in a single fraction had a lower biochemical control rate compared to patients receiving 38 Gy in 4 fractions or 27 Gy in 2 fractions. Randomized prospective trials with a longer follow-up are necessary to confirm our results, and define total doses and dose per fraction for HDR-BT in patients with LPC.
- Published
- 2021
23. The regulation of the DNA damage response at telomeres: Focus on kinases
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Galli, M, Frigerio, C, Longhese, M, Clerici, M, Galli M., Frigerio C., Longhese M. P., Clerici M., Galli, M, Frigerio, C, Longhese, M, Clerici, M, Galli M., Frigerio C., Longhese M. P., and Clerici M.
- Abstract
The natural ends of linear chromosomes resemble those of accidental double-strand breaks (DSBs). DSBs induce a multifaceted cellular response that promotes the repair of lesions and slows down cell cycle progression. This response is not elicited at chromosome ends, which are organized in nucleoprotein structures called telomeres. Besides counteracting DSB response through specialized telomere-binding proteins, telomeres also prevent chromosome shortening. Despite of the different fate of telomeres and DSBs, many proteins involved in the DSB response also localize at telomeres and participate in telomere homeostasis. In particular, the DSB master regulators Tel1/ATM and Mec1/ATR contribute to telomere length maintenance and arrest cell cycle progression when chromosome ends shorten, thus promoting a tumor-suppressive process known as replicative senescence. During senescence, the actions of both these apical kinases and telomere-binding proteins allow checkpoint activation while bulk DNA repair activities at telomeres are still inhibited. Checkpoint-mediated cell cycle arrest also prevents further telomere erosion and deprotection that would favor chromosome rearrangements, which are known to increase cancer-associated genome instability. This review summarizes recent insights into functions and regulation of Tel1/ATM and Mec1/ATR at telomeres both in the presence and in the absence of telomerase, focusing mainly on discoveries in budding yeast.
- Published
- 2021
24. PO-1457 Hypofractionated palliative RT in patients unfit of standard RT; survival and toxicity outcomes
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Delishaj, D., primary, Colangelo, F., additional, Mandurino, G., additional, D'Amico, R., additional, Alghisi, A., additional, De Nobili, G., additional, Butti, I., additional, Cocchi, A., additional, Bonsignore, F., additional, Sangalli, G., additional, Frigerio, C., additional, Declich, F., additional, and Soatti, C.P., additional
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- 2022
- Full Text
- View/download PDF
25. Severe Acute Respiratory Syndrome Coronavirus 2 and Medical Evacuation in Lombardy: Lessons Learned from an Unprecedented Pandemic.
- Author
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Stucchi R, Ripoll-Gallardo A, Sechi GM, Weinstein ES, Villa GF, Frigerio C, Federighi F, Grasselli G, Zoli A, Bonora R, and Fumagalli R
- Subjects
- Humans, Middle Aged, Pandemics, Disease Outbreaks, Federal Government, SARS-CoV-2, COVID-19 epidemiology
- Abstract
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerging infectious disease pandemic developed in Lombardy (northern Italy) during the last week of February 2020 with a progressive increase of patients presenting with serious clinical findings. Despite the efforts of the Central Italian Government, regional resources were rapidly at capacity. The solution was to plan the medical evacuation (MEDEVAC) of 119 critically ill patients (median age 61 years) to in-patient intensive care units in other Italian regions (77) and Germany (42). Once surviving patients were deemed suitable, the repatriation process concluded the assignment. The aim of this report is to underline the importance of a rapid organization and coordination process between different nodes of an effective national and international network during an emerging infectious disease outbreak and draw lessons learned from similar published reports.
- Published
- 2023
- Full Text
- View/download PDF
26. “3CRT-like” dynamic MLC IMRT for whole breast irradiation: development of an inverse planning optimization protocol for OARs sparing and dosimetric comparison versus conventional 3DCRT and VMAT
- Author
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Sangalli, G., primary, Frigerio, C., additional, Butti, I., additional, Bonsignore, F., additional, Alghisi, A., additional, Cocchi, A., additional, D’Amico, R., additional, Delishaj, D., additional, De Nobili, G., additional, Declich, F., additional, and Soatti, C., additional
- Published
- 2021
- Full Text
- View/download PDF
27. 1446P Weekly hypofractionated palliative radiotherapy in poor performance status and elderly patients unfit for standard radiotherapy: Survival, acute and late toxicity outcomes
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Soatti, C.P., primary, Colangelo, F., additional, Mandurino, G., additional, D'Amico, R., additional, Alghisi, A., additional, De Nobili, G., additional, Cocchi, A., additional, Sangalli, G., additional, Frigerio, C., additional, Butti, I., additional, Bonsignore, F., additional, Declich, F., additional, and Delishaj, D., additional
- Published
- 2021
- Full Text
- View/download PDF
28. Genetic variability associated withOAS1expression in myeloid cells increases the risk of Alzheimer’s disease and severe COVID-19 outcomes
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Juan A. Botía, Thomas M. Piers, Magusali N, Jennifer M. Pocock, Panichnantakul P, Yaman U, Keeley J. Brookes, Maryam Shoai, Graham Ac, Sala Frigerio C, Sevinc Bayram, Mina Ryten, Escott-Price, Kevin Morgan, Regina H. Reynolds, Eftychia Bellou, Dervis A. Salih, John Hardy, Tamar Guetta-Baranes, and Sokolova D
- Subjects
Innate immune system ,Microglia ,Disease ,Biology ,medicine.disease ,medicine.anatomical_structure ,Interferon ,Immunology ,medicine ,Tumor necrosis factor alpha ,Alzheimer's disease ,Gene ,medicine.drug ,Genetic association - Abstract
Genome-wide association studies of late-onset Alzheimer’s disease (AD) have highlighted the importance of variants associated with genes expressed by the innate immune system in determining risk for AD. Recently, we and others have shown that genes associated with variants that confer risk for AD are significantly enriched in transcriptional networks expressed by amyloid-responsive microglia. This allowed us to predict new risk genes for AD, including the interferon-responsive oligoadenylate synthetase 1 (OAS1). However, the function ofOAS1within microglia and its genetic pathway are not known. Using genotyping from 1,313 individuals with sporadic AD and 1,234 control individuals, we confirm that theOAS1variant, rs1131454, is associated with increased risk for AD and decreasedOAS1expression. Moreover, we note that the same locus was recently associated with critical illness in response to COVID-19, linking variants that are associated with AD and a severe response to COVID-19. By analysing single-cell RNA-sequencing (scRNA-seq) data of isolated microglia fromAPPNL-G-Fknock-in and wild-type C57BL/6J mice, we identify a transcriptional network that is significantly upregulated with age and amyloid deposition, and contains the mouse orthologueOas1a, providing evidence thatOas1aplays an age-dependent function in the innate immune system. We identify a similar interferon-related transcriptional network containingOAS1by analysing scRNA-seq data from human microglia isolated from individuals with AD. Finally, using human iPSC-derived microglial cells (h-iPSC-Mg), we see thatOAS1is required to limit the pro-inflammatory response of microglia. When stimulated with interferon-gamma (IFN-γ), we note that cells with lowerOAS1expression show an exaggerated pro-inflammatory response, with increased expression and secretion of TNF-α. Collectively, our data support a link between genetic risk for AD and susceptibility to critical illness with COVID-19 centred onOAS1and interferon signalling, a finding with potential implications for future treatments of both AD and COVID-19, and the development of biomarkers to track disease progression.
- Published
- 2021
29. The Chromatin Landscape around DNA Double-Strand Breaks in Yeast and Its Influence on DNA Repair Pathway Choice.
- Author
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Frigerio C, Di Nisio E, Galli M, Colombo CV, Negri R, and Clerici M
- Subjects
- Saccharomyces cerevisiae metabolism, Histones metabolism, Nucleosomes metabolism, DNA Repair, DNA metabolism, DNA End-Joining Repair, DNA Helicases metabolism, Chromatin metabolism, DNA Breaks, Double-Stranded
- Abstract
DNA double-strand breaks (DSBs) are harmful DNA lesions, which elicit catastrophic consequences for genome stability if not properly repaired. DSBs can be repaired by either non-homologous end joining (NHEJ) or homologous recombination (HR). The choice between these two pathways depends on which proteins bind to the DSB ends and how their action is regulated. NHEJ initiates with the binding of the Ku complex to the DNA ends, while HR is initiated by the nucleolytic degradation of the 5'-ended DNA strands, which requires several DNA nucleases/helicases and generates single-stranded DNA overhangs. DSB repair occurs within a precisely organized chromatin environment, where the DNA is wrapped around histone octamers to form the nucleosomes. Nucleosomes impose a barrier to the DNA end processing and repair machinery. Chromatin organization around a DSB is modified to allow proper DSB repair either by the removal of entire nucleosomes, thanks to the action of chromatin remodeling factors, or by post-translational modifications of histones, thus increasing chromatin flexibility and the accessibility of repair enzymes to the DNA. Here, we review histone post-translational modifications occurring around a DSB in the yeast Saccharomyces cerevisiae and their role in DSB repair, with particular attention to DSB repair pathway choice.
- Published
- 2023
- Full Text
- View/download PDF
30. Surface ruptures following the 30 October 2016 M w 6.5 Norcia earthquake, central Italy
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Civico, R., Pucci, S., Villani, F., Pizzimenti, L., De Martini, P. M., Nappi, R., Agosta, F., Alessio, G., Alfonsi, L., Amanti, M., Amoroso, S., Aringoli, D., Auciello, E., Azzaro, R., Baize, S., Bello, S., Benedetti, L., Bertagnini, A., Binda, G., Bisson, M., Blumetti, A. M., Bonadeo, L., Boncio, P., Bornemann, P., Branca, S., Braun, T., Brozzetti, F., Brunori, C. A., Burrato, P., Caciagli, M., Campobasso, C., Carafa, M., Cinti, F. R., Cirillo, D., Comerci, V., Cucci, L., De Ritis, R., Deiana, G., Del Carlo, P., Del Rio, L., Delorme, A., Di Manna, P., Di Naccio, D., Falconi, L., Falcucci, E., Farabollini, P., Faure Walker, J. P., Ferrarini, F., Ferrario, M. F., Ferry, M., Feuillet, N., Fleury, J., Fracassi, U., Frigerio, C., Galluzzo, F., Gambillara, R., Gaudiosi, G., Goodall, H., Gori, S., Gregory, L. C., Guerrieri, L., Hailemikael, S., Iezzi, F., Invernizzi, C., Jablonská, D., Jacques, E., Jomard, H., Kastelic, V., Klinger, Y., Lavecchia, G., Leclerc, F., Liberi, F., Lisi, A., Livio, F., Lo Sardo, L., Malet, J. P., Mariucci, M. T., Materazzi, M., Mazzarini, F., Mccaffrey, K. J. W., Michetti, A. M., Mildon, Z. K., Montone, P., Moro, M., Nave, R., Odin, M., Pace, B., Paggi, S., Pagliuca, N., Pambianchi, G., Pantosti, D., Patera, A., Pérouse, E., Pezzo, G., Piccardi, L., Pierantoni, P. P., Pignone, M., Pinzi, S., Pistolesi, E., Point, J., Pozzi, A., Proposito, M., Puglisi, C., Puliti, I., Ricci, T., Ripamonti, Licia, Rizza, M., Roberts, G. P., Roncoroni, M., Sapia, V., Saroli, M., Sciarra, A., Scotti, O., Skupinski, G., Smedile, A., Tarabusi, G., Tarquini, S., Terrana, S., Tesson, J., Tondi, E., Valentini, A., Vallone, R., Van der Woerd, J., Vannoli, P., Venuti, A., Vittori, E., Volatili, T., Wedmore, L. N. J., Wilkinson, M., Zambrano, M., Istituto Nazionale di Geofisica e Vulcanologia [Bologna] ( INGV ), Géosciences Montpellier, Institut national des sciences de l'Univers ( INSU - CNRS ) -Université de Montpellier ( UM ) -Université des Antilles ( UA ) -Centre National de la Recherche Scientifique ( CNRS ), Istituto Nazionale di Geofisica e Vulcanologia - Sezione di Bologna (INGV), Istituto Nazionale di Geofisica e Vulcanologia, Institut national des sciences de l'Univers (INSU - CNRS)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Université des Antilles (UA), Géoazur (GEOAZUR 7329), Institut national des sciences de l'Univers (INSU - CNRS)-Institut de Recherche pour le Développement (IRD [France-Sud])-Centre National de la Recherche Scientifique (CNRS)-Observatoire de la Côte d'Azur, Université Côte d'Azur (UCA)-Université Côte d'Azur (UCA), Hailemikael, S., Institut national des sciences de l'Univers (INSU - CNRS)-Université de Montpellier (UM)-Université des Antilles (UA)-Centre National de la Recherche Scientifique (CNRS), Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de la Côte d'Azur, COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Université Côte d'Azur (UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Université Côte d'Azur (UCA)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD [France-Sud]), Institut de physique du globe de Strasbourg (IPGS), Institut national des sciences de l'Univers (INSU - CNRS)-Université Louis Pasteur - Strasbourg I-Centre National de la Recherche Scientifique (CNRS), Université Côte d'Azur (UCA)-Université Côte d'Azur (UCA)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD [France-Sud]), Institut Terre Environnement Strasbourg (ITES), École Nationale du Génie de l'Eau et de l'Environnement de Strasbourg (ENGEES)-Université de Strasbourg (UNISTRA)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS), Agosta, F., Alessio, G., Alfonsi, L., Amanti, M., Amoroso, S., Aringoli, D., Auciello, E., Azzaro, R., Baize, S., Bello, S., Benedetti, L., Bertagnini, A., Binda, G., Bisson, M., Blumetti, A. M., Bonadeo, L., Boncio, P., Bornemann, P., Branca, S., Braun, T., Brozzetti, F., Brunori, C. A., Burrato, P., Caciagli, M., Campobasso, C., Carafa, M., Cinti, F. R., Cirillo, D., Comerci, V., Cucci, L., De Ritis, R., Deiana, G., Del Carlo, P., Del Rio, L., Delorme, A., Di Manna, P., Di Naccio, D., Falconi, L., Falcucci, E., Farabollini, P., Faure Walker, J. P., Ferrarini, F., Ferrario, M. F., Ferry, M., Feuillet1, N., Fleury, J., Fracassi, U., Frigerio, C., Galluzzo, F., Gambillara, R., Gaudiosi, G., Goodall, H., Gori, S., Gregory, L. C., Guerrieri, L., Iezzi, F., Invernizzi, C., Jablonská, D., Jacques, E., Jomard, H., Kastelic, V., Klinger, Y., Lavecchia, G., Leclerc, F., Liberi, F., Lisi, A., Livio, F., Lo Sard8, L., Malet, J. P., Mariucci, M. T., Materazzi5, M., Mazzarini, F., Mccaffrey, K. J. W., Michett, A. M., Mildon, Z. K., Montone, P., Moro, M., Nave, R., Odin, M., Pace, B., Paggi, S., Pagliuca, N., Pambianchi, G., Pantosti, D., Patera, A., Pérouse, E., Pezzo, G., Piccardi, L., Pierantoni, P. P., Pignone, M., Pinzi, S., Pistolesi, E., Point, J., Pozzi, A., Proposito, M., Puglisi, C., Puliti, I., Ricci, T., Ripamonti, L., Rizza, M., Roberts, G. P., Roncoroni, M., Sapia, V., Saroli, M., Sciarra, A., Scotti, O., Skupinski, G., Smedile, A., Tarabusi, G., Tarquini, S., Terrana, S., Tesson, J., Tondi, E., Valentini, A., Vallone, R., Van der Woerd, J., Vannoli, P., Venuti, A., Vittori, E., Volatili, T., Wedmore, L. N. J., Wilkinson, M., Zambrano, M., Institut de Physique du Globe de Paris (IPGP), and Institut national des sciences de l'Univers (INSU - CNRS)-Université Paris Diderot - Paris 7 (UPD7)-Université de La Réunion (UR)-Institut de Physique du Globe de Paris (IPG Paris)-Centre National de la Recherche Scientifique (CNRS)
- Subjects
Surface (mathematics) ,Surface rupture ,010504 meteorology & atmospheric sciences ,[SDU.STU.GP]Sciences of the Universe [physics]/Earth Sciences/Geophysics [physics.geo-ph] ,Field data ,Geography, Planning and Development ,[SDU.STU]Sciences of the Universe [physics]/Earth Sciences ,Kinematics ,Fault (geology) ,010502 geochemistry & geophysics ,01 natural sciences ,Surface faulting ,geological prompt surveys ,lcsh:G3180-9980 ,Earth and Planetary Sciences (miscellaneous) ,coseismic ruptures ,normal faulting ,2016–2017 seismic sequence ,central Italy ,Coseismic rupture ,ComputingMilieux_MISCELLANEOUS ,0105 earth and related environmental sciences ,lcsh:Maps ,[SDU.STU.TE]Sciences of the Universe [physics]/Earth Sciences/Tectonics ,Geological prompt survey ,2016-2017 seismic sequence ,Geological prompt surveys ,Normal faulting ,Coseismic ruptures ,Central Italy ,geography ,geography.geographical_feature_category ,Oblique case ,[ SDU.STU ] Sciences of the Universe [physics]/Earth Sciences ,es ,13. Climate action ,Geology ,Seismology - Abstract
We present a 1:25,000 scale map of the coseismic surface ruptures following the 30 October 2016 M-w 6.5 Norcia normal-faulting earthquake, central Italy. Detailed rupture mapping is based on almost 11,000 oblique photographs taken from helicopter flights, that has been verified and integrated with field data (>7000 measurements). Thanks to the common efforts of the Open EMERGEO Working Group (130 people, 25 research institutions and universities from Europe), we were able to document a complex surface faulting pattern with a dominant strike of N135 degrees-160 degrees (SW-dipping) and a subordinate strike of N320 degrees-345 degrees (NE-dipping) along about 28km of the active Mt. Vettore-Mt. Bove fault system. Geometric and kinematic characteristics of the rupture were observed and recorded along closely spaced, parallel or subparallel, overlapping or step-like synthetic and antithetic fault splays of the activated fault systems, comprising a total surface rupture length of approximately 46km when all ruptures were considered.
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- 2018
31. Rapid reorganization of the Milan metropolitan public safety answering point operations during the initial phase of the COVID-19 outbreak in Italy
- Author
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Marrazzo, F, Spina, S, Pepe, P, D'Ambrosio, A, Bernasconi, F, Manzoni, P, Graci, C, Frigerio, C, Sacchi, M, Stucchi, R, Teruzzi, M, Baraldi, S, Lovisari, F, Langer, T, Sforza, A, Migliari, M, Sechi, G, Sangalli, F, Fumagalli, R, Marrazzo, Francesco, Spina, Stefano, Pepe, Paul E, D'Ambrosio, Annapaola, Bernasconi, Filippo, Manzoni, Paola, Graci, Carmela, Frigerio, Cristina, Sacchi, Marco, Stucchi, Riccardo, Teruzzi, Mario, Baraldi, Sara, Lovisari, Federica, Langer, Thomas, Sforza, Alessandra, Migliari, Maurizio, Sechi, Giuseppe, Sangalli, Fabio, Fumagalli, Roberto, Marrazzo, F, Spina, S, Pepe, P, D'Ambrosio, A, Bernasconi, F, Manzoni, P, Graci, C, Frigerio, C, Sacchi, M, Stucchi, R, Teruzzi, M, Baraldi, S, Lovisari, F, Langer, T, Sforza, A, Migliari, M, Sechi, G, Sangalli, F, Fumagalli, R, Marrazzo, Francesco, Spina, Stefano, Pepe, Paul E, D'Ambrosio, Annapaola, Bernasconi, Filippo, Manzoni, Paola, Graci, Carmela, Frigerio, Cristina, Sacchi, Marco, Stucchi, Riccardo, Teruzzi, Mario, Baraldi, Sara, Lovisari, Federica, Langer, Thomas, Sforza, Alessandra, Migliari, Maurizio, Sechi, Giuseppe, Sangalli, Fabio, and Fumagalli, Roberto
- Abstract
Objective: To quantify how the first public announcement of confirmed coronavirus disease 2019 (COVID-19) in Italy affected a metropolitan region's emergency medical services (EMS) call volume and how rapid introduction of alternative procedures at the public safety answering point (PSAP) managed system resources. Methods: PSAP processes were modified over several days including (1) referral of non-ill callers to public health information call centers; (2) algorithms for detection, isolation, or hospitalization of suspected COVID-19 patients; and (3) specialized medical teams sent to the PSAP for triage and case management, including ambulance dispatches or alternative dispositions. Call volumes, ambulance dispatches, and response intervals for the 2 weeks after announcement were compared to 2017–2019 data and the week before. Results: For 2 weeks following outbreak announcement, the primary-level PSAP (police/fire/EMS) averaged 56% more daily calls compared to prior years and recorded 9281 (106% increase) on Day 4, averaging ∼400/hour. The secondary-level (EMS) PSAP recorded an analogous 63% increase with 3863 calls (∼161/hour; 264% increase) on Day 3. The COVID-19 response team processed the more complex cases (n = 5361), averaging 432 ± 110 daily (∼one-fifth of EMS calls). Although community COVID-19 cases increased exponentially, ambulance response intervals and dispatches (averaging 1120 ± 46 daily) were successfully contained, particularly compared with the week before (1174 ± 40; P = 0.02). Conclusion: With sudden escalating EMS call volumes, rapid reorganization of dispatch operations using tailored algorithms and specially assigned personnel can protect EMS system resources by optimizing patient dispositions, controlling ambulance allocations and mitigating hospital impact. Prudent population-based disaster planning should strongly consider pre-establishing similar highly coordinated medical taskforce contingencies.
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- 2020
32. World Scientific-Now Publishers Series in Business
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Frigerio, Chiara, Martinez, M., Iacono, M. P., Rajola, Federico, Jacks, T., Frigerio C. (ORCID:0000-0002-2648-6905), Rajola F. (ORCID:0000-0002-8591-7314), Frigerio, Chiara, Martinez, M., Iacono, M. P., Rajola, Federico, Jacks, T., Frigerio C. (ORCID:0000-0002-2648-6905), and Rajola F. (ORCID:0000-0002-8591-7314)
- Abstract
In this chapter, we report the organizational, technological, and individual information technology (IT) issues of Italian IT workers. The participants of our survey are mostly IT professionals, working full time in non-managerial positions. IT strategic planning, IT service management, knowledge management, alignment between IT and business were among the most pressing organizational issues. Top technology concerns include enterprise application integration, business intelligence/analytics, collaborative and workflow tools, and networks/telecommunications. Italian IT employees seem to be satisfied with their work and perceived their workloads to be meaningful. They exhibited low levels of turnover intention and felt quite secure in their jobs.
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- 2020
33. PEN–2 gene mutation in a familial Alzheimer’s disease case
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Sala Frigerio*, C., Piscopo*, P., Calabrese, E., Crestini, A., MalvezziCampeggi, L., Civita di Fava, R., Fogliarino, S., Albani, D., Marcon, G., Cherchi, R., Piras, R., Forloni, G., and Confaloni, A.
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- 2005
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34. Association between malnutrition and cognitive impairment in parkinson’s disease and parkinsonism: preliminary data analysis
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Colosimo, S., primary, Ferri, V., additional, Frigerio, C., additional, Calati, A., additional, Cereda, E., additional, Bolliri, C., additional, Caronni, S., additional, Pusani, C., additional, Sacilotto, G., additional, Zecchinelli, A., additional, Colombo, A., additional, Reali, E., additional, Cereda, V., additional, Cassani, E., additional, Pezzoli, G., additional, and Barichella, M., additional
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- 2020
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35. PO-1204: Clinical outcomes and prognostic factors in patients with localized prostate cancer treated HDR BT
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Delishaj, D., primary, Soatti, C.P., additional, Frigerio, C., additional, D'amico, R., additional, Bonsignore, F., additional, Fumagalli, I.C., additional, De Nobili, G., additional, Cocchi, A., additional, Vola, A., additional, Sangalli, G., additional, Declich, F., additional, and Colombo, A., additional
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- 2020
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36. OC.06.4 A LOW-STARCH DIET IMPROVES BLOATING SEVERITY IN FUNCTIONAL BLOATING PATIENTS WITH SUCRASE-ISOMALTASE GENE VARIANTS
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Di Stefano, M., primary, Lapia, F., additional, Bonaso, V., additional, Sabatini, U., additional, Frigerio, C., additional, Pagani, E., additional, Corazza, G.R., additional, and Di Sabatino, A., additional
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- 2020
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37. T01.02.22 SIX-FOOD ELIMINATION DIET (SFED) IN EOSINOPHILIC ESOPHAGITIS AND EOSINOPHILIC GASTROENTERITIS
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Di Stefano, M., primary, Frigerio, C., additional, Schembari, G., additional, Lapia, F., additional, Sabatini, U., additional, Pagani, E., additional, Corazza, G.R., additional, and Di Sabatino, A., additional
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- 2020
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38. T05.02.2 THE ROLE OF SERUM CALPROTECTIN IN THE NON-INVASIVE, DIFFERENTIAL DIAGNOSIS BETWEEN INFLAMMATORY BOWEL DISEASE AND IRRITABLE BOWEL SYNDROME
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Di Stefano, M., primary, Mengoli, C., additional, Vernero, M., additional, Sabatini, U., additional, Lapia, F., additional, Frigerio, C., additional, Pagani, E., additional, Miceli, E., additional, Giuffrida, P., additional, Corazza, G.R., additional, and Di Sabatino, A., additional
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- 2020
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39. A database of the coseismic effects following the 30 October 2016 Norcia earthquake in Central Italy
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Villani, Fabio, Civico, Riccardo, Pucci, Stefano, Pizzimenti, Luca, Nappi, Rosa, De Martini, Paolo Marco, Agosta, F., Alessio, G., Alfonsi, L., Amanti, M., Amoroso, S., Aringoli, D., Auciello, E., Azzaro, R., Baize, S., Bello, S., Benedetti, L., Bertagnini, A., Binda, G., Bisson, M., Blumetti, A.M., Bonadeo, L., Boncio, P., Bornemann, P., Branca, S., Braun, T., Brozzetti, F., Brunori, C.A., Burrato, P., Caciagli, M., Campobasso, C., Carafa, M., Cinti, F.R., Cirillo, D., Comerci, V., Cucci, L., De Ritis, R., Deiana, G., Del Carlo, P., Del Rio, L., Delorme, A., Di Manna, P., Di Naccio, D., Falconi, L., Falcucci, E., Farabollini, P., Faure Walker, J.P., Ferrarini, F., Ferrario, M.F., Ferry, M., Feuillet, N., Fleury, J., Fracassi, U., Frigerio, C., Galluzzo, F., Gambillara, R., Gaudiosi, G., Goodall, H., Gori, S., Gregory, L.C., Guerrieri, L., Hailemikael, S., Hollingsworth, J., Iezzi, F., Invernizzi, C., Jablonská, D., Jacques, E., Jomard, H., Kastelic, V., Klinger, Y., Lavecchia, G., Leclerc, F., Liberi, F., Lisi, A., Livio, F., Lo Sardo, L., Malet, J.P., Mariucci, M.T., Materazzi, M., Maubant, L., Mazzarini, F., McCaffrey, K.J.W., Michetti, A.M., Mildon, Z.K., Montone, P., Moro, M., Nave, R., Odin, M., Pace, B., Paggi, S., Pagliuca, N., Pambianchi, G., Pantosti, D., Patera, A., Pérouse, E., Pezzo, G., Piccardi, L., Pierantoni, P.P., Pignone, M., Pinzi, S., Pistolesi, E., Point, J., Pousse, L., Pozzi, A., Proposito, M., Puglisi, C., Puliti, I., Ricci, T., Ripamonti, L., Rizza, M., Roberts, G.P., Roncoroni, M., Sapia, V., Saroli, M., Sciarra, A., Scotti, O., Skupinski, G., Smedile, A., Soquet, A., Tarabusi, G., Tarquini, S., Terrana, S., Tesson, J., Tondi, E., Valentini, A., Vallone, R., Van der Woerd, J., Vannoli, P., Venuti, A., Vittori, E., Volatili, T., Wedmore, L.N.J., Wilkinson, M., Zambrano, M., Istituto Nazionale di Geofisica e Vulcanologia - Sezione di Roma (INGV), Istituto Nazionale di Geofisica e Vulcanologia, Istituto Nazionale di Geofisica e Vulcanologia - Sezione di Palermo (INGV), Istituto sull’Inquinamento Atmosferico (CNR-IIA), Consiglio Nazionale delle Ricerche (CNR), Institut de Radioprotection et de Sûreté Nucléaire (IRSN), Università degli studi 'G. d'Annunzio' Chieti-Pescara [Chieti-Pescara] (Ud'A), Laboratoire Image, Ville, Environnement (LIVE), Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS), Littoral, Environnement, Télédétection, Géomatique (LETG - Caen), Littoral, Environnement, Télédétection, Géomatique UMR 6554 (LETG), Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU)-Université d'Angers (UA)-Université de Nantes (UN)-École pratique des hautes études (EPHE)-Université de Brest (UBO)-Université de Rennes 2 (UR2), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Centre National de la Recherche Scientifique (CNRS)-Université de Caen Normandie (UNICAEN), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Centre National de la Recherche Scientifique (CNRS), Institut de Physique du Globe de Paris (IPGP), Institut national des sciences de l'Univers (INSU - CNRS)-IPG PARIS-Université Paris Diderot - Paris 7 (UPD7)-Université de La Réunion (UR)-Centre National de la Recherche Scientifique (CNRS), Dipartimento di Scienze Fisiche, Informatiche e Matematiche [Modena], Università degli Studi di Modena e Reggio Emilia (UNIMORE), Géosciences Montpellier, Institut national des sciences de l'Univers (INSU - CNRS)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Université des Antilles (UA), Centre européen de recherche et d'enseignement des géosciences de l'environnement (CEREGE), Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Collège de France (CdF)-Institut national des sciences de l'Univers (INSU - CNRS)-Aix Marseille Université (AMU)-Institut National de la Recherche Agronomique (INRA), Géoazur (GEOAZUR 7329), Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de la Côte d'Azur, Université Côte d'Azur (UCA)-Université Côte d'Azur (UCA)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD [France-Sud]), Institut de physique du globe de Strasbourg (IPGS), Université de Strasbourg (UNISTRA)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS), Istituto Nazionale di Geofisica e Vulcanologia – Sezione di Pisa (INGV), Laboratoire de géologie de l'ENS (LGE), Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Département des Géosciences - ENS Paris, École normale supérieure - Paris (ENS Paris)-École normale supérieure - Paris (ENS Paris), Institut des Sciences de la Terre (ISTerre), Université Grenoble Alpes (UGA)-Centre National de la Recherche Scientifique (CNRS)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-PRES Université de Grenoble-Institut de recherche pour le développement [IRD] : UR219-Institut national des sciences de l'Univers (INSU - CNRS)-Institut Français des Sciences et Technologies des Transports, de l'Aménagement et des Réseaux (IFSTTAR)-Université Joseph Fourier - Grenoble 1 (UJF), Italian National agency for new technologies, Energy and sustainable economic development [Frascati] (ENEA), Departimento di Scienze della Terra [Camerino], Università di Camerino (UNICAM), Laboratoire d'Ecologie Alpine (LECA), Centre National de la Recherche Scientifique (CNRS)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Université Joseph Fourier - Grenoble 1 (UJF)-Université Grenoble Alpes (UGA), Dynamique globale et déformation active (IPGS) (IPGS-DGDA), Université de Strasbourg (UNISTRA)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS), National Research Council of Italy | Consiglio Nazionale delle Ricerche (CNR), Institut de Recherche pour le Développement (IRD)-Institut National de la Recherche Agronomique (INRA)-Aix Marseille Université (AMU)-Collège de France (CdF (institution))-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS), Normandie Université (NU)-Normandie Université (NU)-Université d'Angers (UA)-École Pratique des Hautes Études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université de Brest (UBO)-Université de Rennes 2 (UR2)-Centre National de la Recherche Scientifique (CNRS)-Institut de Géographie et d'Aménagement Régional de l'Université de Nantes (IGARUN), Université de Nantes (UN)-Université de Nantes (UN)-Université de Caen Normandie (UNICAEN), Université de Nantes (UN)-Université de Nantes (UN), Institut national des sciences de l'Univers (INSU - CNRS)-Université Paris Diderot - Paris 7 (UPD7)-Université de La Réunion (UR)-Institut de Physique du Globe de Paris (IPG Paris)-Centre National de la Recherche Scientifique (CNRS), Università degli Studi di Modena e Reggio Emilia = University of Modena and Reggio Emilia (UNIMORE), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Université Côte d'Azur (UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Université Côte d'Azur (UCA)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD [France-Sud]), Laboratoire de géologie de l'ENS (LGENS), École normale supérieure - Paris (ENS-PSL), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-École normale supérieure - Paris (ENS-PSL), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL), Institut Français des Sciences et Technologies des Transports, de l'Aménagement et des Réseaux (IFSTTAR)-Institut national des sciences de l'Univers (INSU - CNRS)-Institut de recherche pour le développement [IRD] : UR219-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019]), Università degli Studi di Camerino = University of Camerino (UNICAM), Laboratoire d'Ecologie Alpine (LECA ), Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019]), Aix Marseille Université (AMU)-Institut national des sciences de l'Univers (INSU - CNRS)-Collège de France (CdF (institution))-Institut de Recherche pour le Développement (IRD)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Recherche Agronomique (INRA), Normandie Université (NU)-Normandie Université (NU)-Université d'Angers (UA)-École pratique des hautes études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université de Brest (UBO)-Université de Rennes 2 (UR2), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Centre National de la Recherche Scientifique (CNRS)-Institut de Géographie et d'Aménagement Régional de l'Université de Nantes (IGARUN), Institut national des sciences de l'Univers (INSU - CNRS)-Université de Montpellier (UM)-Université des Antilles (UA)-Centre National de la Recherche Scientifique (CNRS), École normale supérieure - Paris (ENS Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-École normale supérieure - Paris (ENS Paris), Università degli Studi di Camerino (UNICAM), Puglisi, C., Proposito, M., Hailemikael, S., Falconi, L., Centre National de la Recherche Scientifique (CNRS)-Université de Rennes 2 (UR2), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Université de Brest (UBO)-École pratique des hautes études (EPHE)-Université de Nantes (UN)-Université d'Angers (UA)-Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU)-Centre National de la Recherche Scientifique (CNRS)-Université de Rennes 2 (UR2), Normandie Université (NU)-Normandie Université (NU), Centre National de la Recherche Scientifique (CNRS)-Université de La Réunion (UR)-Université Paris Diderot - Paris 7 (UPD7)-IPG PARIS-Institut national des sciences de l'Univers (INSU - CNRS), Institut national des sciences de l'Univers (INSU - CNRS)-Institut de Recherche pour le Développement (IRD [France-Sud])-Centre National de la Recherche Scientifique (CNRS)-Observatoire de la Côte d'Azur, Université Côte d'Azur (UCA)-Université Côte d'Azur (UCA), Villani, F., Civico, R., Pucci, S., Pizzimenti, L., Nappi, R., De Martini, P. M., Agosta, F., Alessio, G., Alfonsi, L., Amanti, M., Amoroso, S., Aringoli, D., Auciello, E., Azzaro, R., Baize, S., Bello, S., Benedetti, L., Bertagnini, A., Binda, G., Bisson, M., Blumetti, A. M., Bonadeo, L., Boncio, P., Bornemann, P., Branca, S., Braun, T., Brozzetti, F., Brunori, C. A., Burrato, P., Caciagli, M., Campobasso, C., Carafa, M., Cinti, F. R., Cirillo, D., Comerci, V., Cucci, L., De Ritis, R., Deiana, G., Del Carlo, P., Del Rio, L., Delorme, A., Di Manna, P., Di Naccio, D., Falcucci, E., Farabollini, P., Faure Walker, J. P., Ferrarini, F., Ferrario, M. F., Ferry, M., Feuillet, N., Fleury, J., Fracassi, U., Frigerio, C., Galluzzo, F., Gambillara, R., Gaudiosi, G., Goodall, H., Gori, S., Gregory, L. C., Guerrieri, L., Hollingsworth, J., Iezzi, F., Invernizzi, C., Jablonska, D., Jacques, E., Jomard, H., Kastelic, V., Klinger, Y., Lavecchia, G., Leclerc, F., Liberi, F., Lisi, A., Livio, F., Sardo, L., Malet, J. P., Mariucci, M. T., Materazzi, M., Maubant, L., Mazzarini, F., Mccaffrey, K. J. W., Michetti, A. M., Mildon, Z. K., Montone, P., Moro, M., Nave, R., Odin, M., Pace, B., Paggi, S., Pagliuca, N., Pambianchi, G., Pantosti, D., Patera, A., Perouse, E., Pezzo, G., Piccardi, L., Pierantoni, P. P., Pignone, M., Pinzi, S., Pistolesi, E., Point, J., Pousse, L., Pozzi, A., Puliti, I., Ricci, T., Ripamonti, L., Rizza, M., Roberts, G. P., Roncoroni, M., Sapia, V., Saroli, M., Sciarra, A., Scotti, O., Skupinski, G., Smedile, A., Soquet, A., Tarabusi, G., Tarquini, S., Terrana, S., Tesson, J., Tondi, E., Valentini, A., Vallone, R., Van Der Woerd, J., Vannoli, P., Venuti, A., Vittori, E., Volatili, T., Wedmore, L. N. J., Wilkinson, M., and Zambrano, M.
- Subjects
Statistics and Probability ,data collection ,010504 meteorology & atmospheric sciences ,[SDU.STU.GP]Sciences of the Universe [physics]/Earth Sciences/Geophysics [physics.geo-ph] ,Library and Information Sciences ,010502 geochemistry & geophysics ,computer.software_genre ,01 natural sciences ,Education ,30 October 2016 Norcia earthquake ,Earthquakes ,ground deformation process ,0105 earth and related environmental sciences ,[SDU.STU.TE]Sciences of the Universe [physics]/Earth Sciences/Tectonics ,surface faulting hazard ,Central Apennines ,Database ,Landslide ,data acquisition system ,Extensional definition ,Computer Science Applications ,13. Climate action ,Homogeneous ,Georeference ,ground deformation process, data acquisition system, Central Apennines, 30 October 2016 Norcia earthquake ,Statistics, Probability and Uncertainty ,computer ,Relevant information ,Geology ,Information Systems - Abstract
We provide a database of the coseismic geological surface effects following the Mw 6.5 Norcia earthquake that hit central Italy on 30 October 2016. This was one of the strongest seismic events to occur in Europe in the past thirty years, causing complex surface ruptures over an area of >400 km2. The database originated from the collaboration of several European teams (Open EMERGEO Working Group; about 130 researchers) coordinated by the Istituto Nazionale di Geofisica e Vulcanologia. The observations were collected by performing detailed field surveys in the epicentral region in order to describe the geometry and kinematics of surface faulting, and subsequently of landslides and other secondary coseismic effects. The resulting database consists of homogeneous georeferenced records identifying 7323 observation points, each of which contains 18 numeric and string fields of relevant information. This database will impact future earthquake studies focused on modelling of the seismic processes in active extensional settings, updating probabilistic estimates of slip distribution, and assessing the hazard of surface faulting.
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- 2018
- Full Text
- View/download PDF
40. Towards a map of the Upper Pleistocene loess of the Po Plain Loess Basin (Northern Italy)
- Author
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Zerboni A.[1], Amit R.[2], Baroni C.[3], Coltorti M.[4], Ferrario M.F.[5] Fioraso G.[6], Forno M. G.[7], Frigerio C.[5], Gianotti F.[7] Irace A.[6] Livio F.[5], Mariani G.S. and 1
- Subjects
Loess ,Po plain loess basin ,mapping ,upper pleistocene - Abstract
Upper Pleistocene (MIS 4-2) loess sequences occur in most of continental Europe and in Northern Italy along the Po Plain Loess Basin. Loess is distributed along the flanks of the Po Plain and was deposited on glacial deposits, fluvial terraces, uplifted isolated hills, karst plateaus, slopes and basins of secondary valleys. Loess bodies are generally tiny and affected by pedogenesis, being locally slightly reworked by slope processes and bioturbation. Notwithstanding, loess in the Po Plain is an important archive of paleoenviron-mental record and its mapping provides new insights in paleoenvironmental and palaeoseismic reconstructions of Northern Italy.
- Published
- 2018
41. Correction: A database of the coseismic effects following the 30 October 2016 Norcia earthquake in central Italy (Scientific Data, (2018) 5, 10.1038/sdata.2018.49)
- Author
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Villani, F., Civico, R., Pucci, S., Pizzimenti, L., Nappi, R., De Martini, P. M., Agosta, F., Alessio, G., Alfonsi, L., Amanti, M., Amoroso, S., Aringoli, D., Auciello, E., Azzaro, R., Baize, S., Bello, S., Benedetti, L., Bertagnini, A., Binda, G., Bisson, M., Blumetti, A. M., Bonadeo, L., Boncio, P., Bornemann, P., Branca, S., Braun, T., Brozzetti, F., Brunori, C. A., Burrato, P., Caciagli, M., Campobasso, C., Carafa, M., Cinti, F. R., Cirillo, D., Comerci, V., Cucci, L., De Ritis, R., Deiana, G., Del Carlo, P., Del Rio, L., Delorme, A., Di Manna, P., Di Naccio, D., Falconi, L., Falcucci, E., Farabollini, P., Faure Walker, J. P., Ferrarini, F., Ferrario, M. F., Ferry, M., Feuillet, N., Fleury, J., Fracassi, U., Frigerio, C., Galluzzo, F., Gambillara, R., Gaudiosi, G., Goodall, H., Gori, S., Gregory, L. C., Guerrieri, L., Hailemikael, S., Hollingsworth, J., Iezzi, F., Invernizzi, C., Jablonska, D., Jacques, E., Jomard, H., Kastelic, V., Klinger, Y., Lavecchia, G., Leclerc, F., Liberi, F., Lisi, A., Livio, F., Lo Sardo, L., Malet, J. P., Mariucci, M. T., Materazzi, M., Maubant, L., Mazzarini, F., Mccaffrey, K. J. W., Michetti, A. M., Mildon, Z. K., Montone, P., Moro, M., Nave, R., Odin, M., Pace, B., Paggi, S., Pagliuca, N., Pambianchi, G., Pantosti, D., Patera, A., Perouse, E., Pezzo, G., Piccardi, L., Pierantoni, P. P., Pignone, M., Pinzi, S., Pistolesi, E., Point, J., Pousse, L., Pozzi, A., Proposito, M., Puglisi, C., Puliti, I., Ricci, T., Ripamonti, L., Rizza, M., Roberts, G. P., Roncoroni, M., Sapia, V., Saroli, M., Sciarra, A., Scotti, O., Skupinski, G., Smedile, A., Socquet, A., Tarabusi, G., Tarquini, S., Terrana, S., Tesson, J., Tondi, E., Valentini, A., Vallone, R., Van der Woerd, J., Vannoli, P., Venuti, A., Vittori, E., Volatili, T., Wedmore, L. N. J., Wilkinson, M., and Zambrano, M.
- Published
- 2019
42. Open Innovation Effectiveness in the Financial Services Sector
- Author
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Piobbici, Francesco, Rajola, Federico, Frigerio, Chiara, Piobbici F., Rajola F. (ORCID:0000-0002-8591-7314), Frigerio C. (ORCID:0000-0002-2648-6905), Piobbici, Francesco, Rajola, Federico, Frigerio, Chiara, Piobbici F., Rajola F. (ORCID:0000-0002-8591-7314), and Frigerio C. (ORCID:0000-0002-2648-6905)
- Abstract
Many factors are changing the financial services industry. At first, we have to consider the macroeconomic scenario characterized by low interest rates, leading to a reduction of the institutions’ profitability and promoting investments aimed to increase the organizations’ efficiency. The regulatory framework is another element to consider, since, after the financial crisis, the authorities introduced new norms, some of them are currently under implementation, like the Market in Financial Instruments Directive II, the Insurance Distribution Directive or the General Data Protection Regulation. The last element we have to consider is the technological one: during the years, many innovations changed the customers’ behaviors, introducing new needs that institutions have to take into account in their strategic plans. Google, Apple, Facebook and Amazon, also called GAFA, have introduced new ways to interact with consumers that are based on instant and easy access to different functionalities.
- Published
- 2019
43. 'Il maestro con la classe più grande del mondo'. La rappresentazione della pedagogia di Alberto Manzi nell'intervista TV Buona maestra (1997) e nella fiction Non è mai troppo tardi (2014)
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Polenghi, S., Alfieri, P., Frigerio, C., Debé, A., Felini, D., Aglieri, M., Aglieri, Michele, Michele Aglieri (ORCID:0000-0002-9564-8293), Polenghi, S., Alfieri, P., Frigerio, C., Debé, A., Felini, D., Aglieri, M., Aglieri, Michele, and Michele Aglieri (ORCID:0000-0002-9564-8293)
- Abstract
Il contributo ripercorre la figura di Alberto Manzi attraverso due prodotti audiovisivi: l'intervista TV Buona maestra curata nel 1997 dal Dipartimento di Scienze dell'educazione di Bologna e la fiction Non è mai troppo tardi andata in onda sulla RAI nel 2014. L'obiettivo è di valorizzare dei documenti di sicuro interesse, raccogliere la testimonanza di un grande educatore e di estrarere categorie pedagogiche e riflessioni utili allle professioni educative.
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- 2019
44. Pharmacodynamics of ticlopidine in man in relation to plasma and blood cell concentration
- Author
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Di Perri, T., Pasini, F. L., Frigerio, C., Blardi, P., Centini, F., Messa, G. L., Ghezzi, A., and Volpi, L.
- Published
- 1991
- Full Text
- View/download PDF
45. Postprandial thermogenesis in lactating and non-lactating women from The Gambia
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Frigerio, C., Schutz, Y., Whitehead, R., and Jequier, E.
- Subjects
Thermogenesis -- Research ,Lactation -- Research ,Developing countries -- Health aspects - Abstract
Thirty two Gambian women were studied for postprandial thermogenesis (PT) using indirect calorimetry. Test meals were given to twelve non-pregnant non-lactating women and 10 lactating women in the dry season, and also to ten lactating women in the wet season. Results show that PT of women tested in the dry season was 6 plus or minus 0.4% of the test meal energy content, while PT of lactating women in the wet season was significantly lower. There was no difference in pre- and postprandial respiratory quotients, suggesting that lactation does not change thermogenic response to food and that reduction in PT in the wet season was an adaptive response.
- Published
- 1992
46. Towards a map of the Upper Pleistocene loess in the Po Plain Loess Basin
- Author
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Zerboni, A., Amit, R., Baroni, C., Coltorti, M., Ferrario, M. F., Fioraso, G., Forno, M. G., Frigerio, C., Gianotti, F., Irace, A., DI LIVIO, Fiorenza, Mariani, G. S., Michetti, A. M., Monegato, Giovanni Virgilio, Mozzi, P., Orombelli, G., Perego, Alessia, Porat, N., Rellini, I., Trombino, L., and Cremaschi, M.
- Published
- 2018
47. PV-0142 HDR BRT treatment of non-melanoma skin cancer: outcome and feasibility in a retrospective analysis
- Author
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Delishaj, D., primary, Fumagalli, I.C., additional, D'Amico, R., additional, Sangalli, G., additional, Declich, F., additional, Frigerio, C., additional, and Soatti, C.P., additional
- Published
- 2019
- Full Text
- View/download PDF
48. P.02.15 SERUM CALPROTECTIN ACCURATELY SEPARATES INFLAMMATORY BOWEL DISEASE AND IRRITABLE BOWEL SYNDROME: PRELIMINARY DATA OF A PROSPECTIVE SINGLE CENTRE STUDY
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Di Stefano, M., primary, Giuffrida, P., additional, Mengoli, C., additional, Ceroni, L., additional, Pagani, E., additional, Miceli, E., additional, Frigerio, C., additional, Lapia, F., additional, Sabatini, U., additional, Corazza, G.R., additional, and Di Sabatino, A., additional
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- 2019
- Full Text
- View/download PDF
49. P.01.17 SERUM DIAMINE OXIDASE LEVELS IN PATIENTS WITH IBS AND HEALTHY VOLUNTEERS
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Di Stefano, M., primary, Ceroni, L., additional, De Amici, M., additional, Di Fede, G., additional, Pagani, E., additional, Lapia, F., additional, Frigerio, C., additional, Sabatini, U., additional, Marseglia, G., additional, Corazza, G.R., additional, and Di Sabatino, A., additional
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- 2019
- Full Text
- View/download PDF
50. Stem-cell-derived human microglia transplanted in mouse brain to study human disease.
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Mancuso R, Van Den Daele J, Fattorelli N, Wolfs L, Balusu S, Burton O, Liston A, Sierksma A, Fourne Y, Poovathingal S, Arranz-Mendiguren A, Sala Frigerio C, Claes C, Serneels L, Theys T, Perry VH, Verfaillie C, Fiers M, and De Strooper B
- Subjects
- Amyloid beta-Peptides pharmacology, Animals, Cell Differentiation, Female, Humans, Male, Mice, Mice, Transgenic, Microglia drug effects, Alzheimer Disease genetics, Embryonic Stem Cells cytology, Microglia metabolism, Microglia transplantation, Transcriptome
- Abstract
Although genetics highlights the role of microglia in Alzheimer's disease, one-third of putative Alzheimer's disease risk genes lack adequate mouse orthologs. Here we successfully engraft human microglia derived from embryonic stem cells in the mouse brain. The cells recapitulate transcriptionally human primary microglia ex vivo and show expression of human-specific Alzheimer's disease risk genes. Oligomeric amyloid-β induces a divergent response in human versus mouse microglia. This model can be used to study the role of microglia in neurological diseases.
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- 2019
- Full Text
- View/download PDF
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