1,105 results on '"F Campi"'
Search Results
2. Neurophysiological studies in infants with Vein of Galen aneurismatic malformation (VGAM): Bambino Gesù Children Hospital experience in the last two years
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M. Calì, S. Pro, P.G. Amante, S. Ronci, F. Pugnaloni, F. Calzolari, N. Chukhlantseva, L. Martini, C. Maddaloni, D.U. De Rose, M. Conti, P. De Liso, F. Campi, A. Dotta, and C. Gandolfo
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Obstetrics and Gynecology - Published
- 2023
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3. Meningoencephalitis and intraventricular devices: when intravenous therapy is not enough
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L. Martini, D. De Rose, A. Santisi, C. Maddaloni, F. Pugnaloni, M. Calì, M.P. Ronchetti, F. Campi, A. Dotta, and C. Auriti
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Obstetrics and Gynecology - Published
- 2023
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4. Genetic insight in vein of Galen aneurysmal malformation
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S. Ronci, F. Campi, D. Longo, P. Giliberti, E. Pisaneschi, S. Lozzi, S. Caoci, F. Pugnaloni, M. Calì, A. Di Pede, I. Capolupo, R. Vicario, M.C. Digilio, A. Novelli, A. Dotta, C. Gandolfo, and P. Bagolan
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Obstetrics and Gynecology - Published
- 2023
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5. Neurodevelopmental outcomes of infants with Vein of Galen aneurismatic malformation
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F. Pugnaloni, F. Campi, L. Raho, S. Ronci, M. Calì, I. Bersani, I. Savarese, F. Monaco, J. Rechichi, A. Romiti, F. Savignoni, C. De Marchis, A. Braguglia, C. Gandolfo, and A. Dotta
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Obstetrics and Gynecology - Published
- 2023
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6. Administering 25-hydroxyvitamin D3 in vitamin D-deficient young type 1A diabetic patients reduces reactivity against islet autoantigens
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Francesco Vierucci, Giovanni Federico, M De Donno, Giuseppe Saggese, Emioli Randazzo, Fabrizio Scatena, Marco Bugliani, B. Marchi, Chantal Mathieu, F. Campi, Piero Marchetti, and Daniele Focosi
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Male ,medicine.medical_specialty ,Adolescent ,Interferon-g ,Type 1A diabetes mellitus, Vitamin D, 25-Hydroxyvitamin D, ELISpot, Interferon-g ,ELISpot ,25-Hydroxyvitamin D ,Critical Care and Intensive Care Medicine ,Autoantigens ,Peripheral blood mononuclear cell ,vitamin D deficiency ,Interferon-gamma ,chemistry.chemical_compound ,Insulin-Secreting Cells ,Internal medicine ,medicine ,Vitamin D and neurology ,Humans ,Vitamin D ,Child ,Calcifediol ,Proinsulin ,geography ,Nutrition and Dietetics ,geography.geographical_feature_category ,C-Peptide ,Glutamate Decarboxylase ,C-peptide ,business.industry ,ELISPOT ,Vitamin D Deficiency ,Islet ,medicine.disease ,Diabetes Mellitus, Type 1 ,Type 1A diabetes mellitus ,Endocrinology ,chemistry ,Leukocytes, Mononuclear ,Female ,business - Abstract
We investigated whether improving 25-hydroxyvitamin D status in young type 1A diabetic patients reduces reactivity of peripheral blood mononuclear cells against islet autoantigens and associates with beta-cell functional changes.Eight patients with 25-hydroxyvitamin D deficiency (20 ng/ml), out of 15 consecutive young type 1A diabetic subjects received 25-hydroxyvitamin D3 to achieve and maintain levels above 50 ng/ml for up to one year. Peripheral blood mononuclear cell reactivity (Interferon-γ spots) against beta-cell autoantigens (glutamic acid decarboxylase 65-kD isoform, proinsulin and tyrosine phosphatase-like protein IA-2) and C-peptide during mixed meal were assessed before and after 25-hydroxyvitamin D3 replenishment.Target 25-hydroxyvitamin D blood levels were safely reached and maintained. Peripheral blood mononuclear cell reactivity against glutamic acid decarboxylase 65-kD isoform (3.8 ± 4.0 vs. 45 ± 16) and proinsulin (3.5 ± 3.2 vs. 75 ± 51) decreased significantly (p 0.001 and p 0.02) upon 25-hydroxyvitamin D3 replenishment, which was correlated with 25-hydroxyvitamin D concentrations. C-peptide values remained stable after one year of treatment.Safely restored and maintained 25-hydroxyvitamin D levels associated with reduced peripheral blood mononuclear cell reactivity against beta-cell autoantigens with no significant decrease of beta-cell function in this cohort of patients.
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- 2014
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7. Pitcher Aging Affects Throwing Shoulder Biomechanics and Proprioception: The Italian Experience
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PEGREFFI, FRANCESCO, VITTORI, LEYDI NATALIA, FOSCHI, ELIA, MAIETTA LATESSA, PASQUALINO, PORCELLINI, GIUSEPPE, TENTONI, CLAUDIO, P. Paladini, F. Campi, A. Pellegrini, Meeusen, R., Duchateau, J., Roelands, B., Klass, M., De Geus, B., Baudry, S., Tsolakidis, E., F. Pegreffi, L. Vittori, E. Foschi, P. Latessa Maietta, P. Paladini, F. Campi, A. Pellegrini, G. Porcellini, and C. Tentoni
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education ,Biomechanic ,Baseball ,Proprioception ,human activities - Abstract
Introduction: Baseball is a sport increasingly practiced in Italy. The pitcher is at risk from repetitive stress on the dominant upper arm. Because of this, pitchers train far more on the dominant arm leading to asymptomatic biomechanical changes. The purpose of this study was to compare shoulder intra/extra rotational power and shoulder motor skill in young and senior athletes. Methods: Twenty right-hand healthy pitchers playing for at least four years were recruited : Group A (12±2yrs) and Group B (24±1yrs). Subjects with a history of shoulder dislocation, shoulder surgery or structural injuries to the shoulder complex were excluded from the study. Isokinetic tests (IT) were performed to evaluate intra/extra rotational power, and shoulder motor skill test (SMST) to evaluate proprioception. Results: Performing IT, we have found in both groups a significant higher external rotation compared to internal rotation in the throwing shoulder (TS), while in the contralateral shoulder (CS) the balance was preserved ( p
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- 2012
8. The Dream Digital Signal Processor: Architecture, programming model and application mapping
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C. Mucci, F. Campi, L. Ciccarelli, PIZZOTTI, MATTEO, L. Vanzolini, M. Innocenti, ROSSI, DAVIDE, PERUGINI, LUCA, DE MARCO, TOMMASO, N. VOROS A. ROSTI M. HUEBNER, C. Mucci, D. Rossi, F. Campi, L. Ciccarelli, M. Pizzotti, L. Perugini, L. Vanzolini, T. De Marco, and M. Innocenti
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RECONFIGURABLE ,PICOGA ,MIX-GRAIN ,GRIFFY-C ,DATAPATH - Abstract
This chapter provides an overview of the DREAM digital signal processor. It discusses the programming model and the tool chain used to implement algorithm on the proposed architecture. It finally provides an application mapping example showing quantitative results.
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- 2009
9. Treatment of clavicle fractures
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P, Paladini, A, Pellegrini, G, Merolla, F, Campi, and G, Porcellini
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Review - Abstract
Summary Clavicle fractures are very common injuries in adults (2–5%) and children (10–15%) (1) and represent the 44–66% of all shoulder fractures (2). Despite the high frequency the choice of proper treatment is still a challenge for the orthopedic surgeon. With this review we wants to focus the attention on the basic epidemiology, anatomy, classification, evaluation and management of surgical treatments in relationship with the gravity of injuries. Both conservative and surgical management are possible, and surgeons must choose the most appropriate management modality according to the biologic age, functional demands, and type of lesion. We performed a review of the English literature thought PubMed to produce an evidence-based review of current concept and management of clavicle fracture. We finished taking a comparison with our survey in order to underline our direct experience.
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- 2012
10. Can capsular stretching change the scapulo-humeral coordination in baseball pitchers?
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Andrea Giovanni Cutti, Giuseppe Porcellini, F. Campi, Pietro Tonino, Paolo Paladini, Ilaria Parel, and Andrea Pellegrini
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Orthodontics ,business.industry ,Rehabilitation ,Biophysics ,Asymptomatic ,Trunk ,Sagittal plane ,medicine.anatomical_structure ,Scapula ,medicine ,Orthopedics and Sports Medicine ,Humerus ,medicine.symptom ,business ,Electromagnetic tracking ,Range of motion ,Throwing - Abstract
Main topics:Analysis of clinicalmovement data; Outcome after clinical intervention Introduction: Injury in the throwing shoulder of baseball pitchers andoverhead throwingathletes is common. Previous studies assessed scapular kinematics using electromagnetic tracking devices, demonstrating that patients with impingement have a reproducible pattern of shoulder dyskinesia [1]. In addition, they showeda correlationbetweenposterior shoulder tightness and forward scapular posture and confirmed that baseball players have more forward scapular posture of the dominant arm [2]. Possibly, capsular stretching programs might help restoring a normal scapulo-humeral coordinate. The aim of this study was to test this hypothesis by studying the scapular kinematics before and after a four weeks posterior stretching protocol in asymptomatic baseball pitchers. Patients/materials and methods: Eleven asymptomatic collegiate baseball pitchers were involved in the study. Pitchers were randomly separated in two groups: groupA (6 pitchers) underwent four weeks of a regimented therapy protocol; group B (5 pitchers) didnot received any treatment. Eachpitcherwas testedon two separate days: at the first day of the study (S1) and after four weeks (S2). The ISEO protocol was used to collect the kinematics of trunk, scapula and humerus [3] of both the throwing side (TS) and the contralateral (CS). The scapulo-humeral coordination (SHC) during humerus elevation in the sagittal (FlexExtension – FE) and scapular (AbAdduction – AA) plane was collected and then analyzed by means of coordinationplots, considering a commonhumeral Range of Motion (ROM) from 10◦ to 110◦, divided in steps of 5◦. SHC’s patterns of each subject were compared to age stratified reference bands (RB) computed from healthy subjects [4]. In order to verify if biologicalmodifications occurred, for each subject, firstly, the SHC’s pattern of TS and CS were compared to the age stratified reference bands (RB); secondly, the scapula ROM variations of TS between S1 and S2 were computed and compared to the Smallest Detectable Difference (SDD) of ISEO [5]. Results: The comparison of the SHC patterns with RBs showed that both TS (in S1 and S2) and CS of all subjects are within the correspondent reference bands, except one subject from group B, that presented alterations at TS only in S1. From the comparison of scapula ROM variations (S1–S2) with SDD values, group B showed that significant variations occurred only for one subject in MELA ROM during FE and AA and PA during AA. On the contrary 4 out of 6 pitchers that received the therapy showed clear signed of SHC alterations. Specifically, 4 subjects (67%) had variations in MELA during FE and 3 (50%) inMELAduringAA, and 1 subject in PAduring both FE and AA. These changes were towards the RB mean patterns, proving an improvement of the SHCs of TSs after the physical therapy. It is important to notice that variations in the subjects of group A occurred for both movements (FE and AA), strengthening the conclusion that the variation was real. Discussion and conclusions: This study highlights how posterior capsular stretching protocol can favour the maintenance of the SHC in asymptomatic baseball pitchers. Being a randomly and blinded study all pitchers of group A underwent the physical therapy protocol even if in S1 they had not presented an altered SHC compared to reference bands. The preliminary result of the study can indicate that, in order to prevent the pathologic cascade linked to these sports activities, this physical training protocol might become integral part of thenormal daily exercises of baseball pitchers and over-head athletes.
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- 2015
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11. A Case-Study on Multimedia Applications for the XiRisc Reconfigurable Processor
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C. Mucci, M. Bocchi, P. Gagliardi, L. Ciccarelli, A. Lodi, M. Toma, and F. Campi
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Flexibility (engineering) ,Reduced instruction set computing ,Multimedia ,business.industry ,Computer science ,Quality of service ,Energy consumption ,Application software ,computer.software_genre ,Computer architecture ,Embedded system ,business ,Encoder ,computer ,Digital signal processing - Abstract
Embedded real-time multimedia applications pose several challenges in order to satisfy increasing quality of service (QoS) and energy consumption constraints, that are hardly matched by the capabilities of general-purpose standard processors. Reconfigurable processors, coupling the flexibility of software-programmable devices with the computational efficiency of application specific architectures, represent an appealing trade-off for next generation devices in the digital signal processing application domain. In this paper, we present a benchmarking application for the XiRisc reconfigurable processor, based on a public release of the MPEG-2 video encoder. The introduction of the reconfigurable logic gives a 5/spl times/ performance improvement and a 66% energy saving.
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- 2006
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12. XiSystem: a XiRisc-based SoC with a reconfigurable io module
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A. Cappelli, A. Lodi, M. Bocchi, C. Mucci, M. Innocenti, C. De Bartolomeis, L. Ciccarelli, R. Giansante, A. Deledda, F. Campi, M. Toma, and R. Guerrieri
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- 2005
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13. Radon data from different laboratoriesAn Italian Intercomparison
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F CAMPI, M CARESANA, M FERRARINI, L GARLATI, M PALERMO, R RUSCONI, L SALVATORI, and L VERDI
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- 2005
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14. 40(th) EASD Annual Meeting of the European Association for the Study of Diabetes : Munich, Germany, 5-9 September 2004
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S. Artigas, A V Dreval, Mark I. McCarthy, C Watson, Peter H. Bennett, M Quint, Y Ikeda, E Alpert, F Schiele, H Sekihara, Erik Gylfe, P Lowe, J Kuhlmann, Alain Golay, V Longo, Shahidul Alam Khan Akm., L G Mantovani, M Zawodniak-Szalapska, G Winkler, T Harrity, L Virág, U Johne, Kuo S-W., Linda C Tapsell, J Rodriguez, Michel Komajda, K Kankova, Carole A. Cull, M Sporna, E Estilles, U Ribel, M C Spruce, E Buzzigoli, T Prazak, J K McLaughlin, M K Lingohr, M Lim, F Calara, A Siebenhofer, G Meregalli, Roberto Anichini, A D Baron, R Kurashvili, P C Butler, G I Fantus, T. E. De Gooyer, Park Y-M., R. Walther, S Heinrich, Agnieszka Zawiejska, S Mukherjee, Nikolaos Papanas, G Wong, Ian D. Caterson, David M. Maahs, Shuichi Kaneko, Alexandra E. Butler, Francisco Javier Ampudia-Blasco, O N Kong, Attali J-R., C A Hedman, K Oshinyemi, Nicolle Müller, I C Cranston, N Okumus, M V Vlaiculescu, Balasubramanian Ravikumar, W W Cheatham, K Mukasa, K B Biswas, Annunziata Lapolla, Phil McEwan, G Mader, Gilles Chassot, Dragi Anevski, Werner A. Scherbaum, M Donath, C Hesselmann, R A Gandhi, David E. Moller, Ezio Bonifacio, C Garcia, V Ifandi, P Hornnes, Nieuwenhoven Fav., C Puech, S Pérez-Del-Pulgar, Kim S-R., G Hines, C Rubio Terrés, Michael Gaster, N. Hosszufalusi, A Scholze, Andrew A. Young, Stavros Liatis, F Hariri, S Tan, Paul Valensi, Allan E. Karlsen, J Kim, E. Moberg, J Kaiser, L Berman, G Nelson, A Altkrüger, P Kothare, D B Cook, S Doran, G. van Dijk, Shahnaz Shahinfar, Kim C-S., P Stahl, M Manousaki, S Sigrist, S K Lim, M. P. Stern, A Guberti, C Rezzani, J McKenney, Karl Thomaseth, Sofia Carlsson, M Julia, R Brillante, I Rubesova, T Darkow, E Matsumoto, Wendy M. Macfarlane, M Di Martino, G Bardini, Rossella Menghini, D Duhot, E Farcasiu, Annalisa Natalicchio, I Lindner, J Buvat, Christian L. Brand, Harry Dorchy, Iwona Pietrzak, Z T Luo, P Home, M Ekelund, Jesper Gromada, Kristine Færch, F Piarulli, H Kim, R Mentel, Zsuzsanna K. Zsengellér, Dullaart Rpf., Anton Luger, Thomas A. Pearson, V Manicardi, P Rösen, Feng Y-M., R Morganti, Lars Hansen, Demuth H-U., Haruo Kasai, A Shostak, Rudi Steffensen, G Taylor, Markolf Hanefeld, C Santini, E Hamaguchi, Roberto Miccoli, F Storms, M Cooper, Y Lee, Allison E. Aiello, P Smith, T Suehiro, K Treece, M Waluś, Timothy A Welborn, Simone Baltrusch, E Kontela, S Chai, J Crean, H Yokoyama, Johan G. Eriksson, Rafael Hernández Hernández, J Rodríguez-Saldaña, M P Tornero, G Formoso, D. Lovell, E Bingham, A Mylonakis, M Manteghetti, D Fedele, Antonio Martín-Duce, Ralph A. DeFronzo, D Salcedo, Kurt Højlund, Antonio Petrone, Sheu Whh., C Gutierrez, Flavia Pricci, S Kurita, Z G Abbas, M M Benedetti, Philippe A. Halban, Daniel J. Cox, O Ljungkvist, Justine Davies, J Palsgaard, Lars Sjöström, E Bosi, L Janin-Manificat, W. F. Kelly, M. Fernandez, E Colak, O V Mulyarchik, B Kronshage, F Lang, M Erfurth, Takashi Kadowaki, N Jendrike, U Walter, J Wishart, Y. Neye, D Kim, N Furuhashi, M Barsotti, D Florow, L Ke, L Borgquist, N C Jackson, Ffolliott M. Fisher, V Baskar, K Yoshioka, Bryan A. Wolf, G Chabrier, R Skoumal, Livio Luzi, H Kose, I Pharisien, B. Klein, H Winiarska, M C Johnson, L Griffiths, Nonna Kravchun, C Combe, Baptist Gallwitz, J Zdychova, L Skorda, Jorma Ilonen, W Gao, I N Steen, A Terrinoni, P D Ambery, W Kern, C M Kusminski, Cho M-H., Paolo Pozzilli, Louise G. Grunnet, E Schönle, David R Matthews, Robert W. Taylor, Y Cohen, Kim H-S., M P Eccles, N B Tutuncu, D McDowell, Richard M. Bergenstal, K Takamatsu, T Steiner, Jaan Palgi, Valdemar Grill, N Niculescu, G Federici, S Lehto, P. M. McKeigue, M Barone, Michael E. Trautmann, S Smirnov, J Mannion, M Eto, C Rousseau, M Conti, C S Ernest, Antonio Ceriello, D H Schweitzer, Jung E-D., Andreas Festa, Avijit Lahiri, A Shepelkevich, A Murro, A Kollmann, Jonathan R.S. Arch, R Landgraf, Son H-Y., I Engelsberger, E Agardh, S Rodríguez-Mulero, P J Kraml, K Lee, D. F. Du Toit, E Kim, G Fadini, Williams Ajk., Philip Home, M B Antcieferov, C Perlemoine, D Perrea, Song X-L., D Ruggieri, Krister Bokvist, Heidi Sørensen, Bilbao, G Yoshino, J P Taylor, Shen H-M., S M Furier, R Urquhart, J Wohlgelernter, Jianping Weng, T. Baba, Q Hong, C Silva, Castaigne J-P., M Felaco, X X Zhang, M Jaroň, Milla Rosengård-Bärlund, J G Papp, Toshio Miyata, Lervang H-H., Park M-K., I Kinalska, A Long, Oomen Phn., N Kogawa, Ippolita Patrizia Patera, S. Karadeniz, Dinesh Selvarajah, D S Chung, A Wensaas, Richard Imrich, M Recasens, J Ruxer, O Buchea, E Wilpart, S P Stepanenko, Le Ttd., H Ohgawara, Mariaconsuelo Valentini, A Mondok, M Peltonen, Marianne O. Larsen, K Chatzianagnostou, Agneta Ståhle, A L Ferrari, L Bordier, F Maingrette, A Matsuda, G Vukomanovic, Jakob D. Wikstrom, T Yamakita, E Gorostiaga, J Jin, B Gopalan, Heinz Drexel, S Hewitt, Rury R. Holman, C Dieterle, T L Ruchti, N Asatiani, M Sidira, A Iezzi, A J Sommerfield, D Châtenet, M L Olsen, R Bergemann, C Koehler, T L Kuraeva, B Balas, Christian Berne, E Santos-Mazo, G Smith, A Siejka, R Kožnarová, A Mattina, S Sheikh, A Adomeit, M Rasmussen, J. Fagerudd, N Busciantella Ricci, Nuria Vilarrasa, E Hammar, T L Thoms, L Aydın, Ron G. Rosenfeld, A Nikolajuk, R Gos, C L Morgan, H L Yu, D Dheelchand, S Ramrath, N Boudriga, Jerome I. Rotter, C Jahannault, W M Weston, Folke Lindgärde, M Hertlova, D Knight, A Monroy-Mayorga, E Pardini, A Chamson-Reig, B Franke, Janie McCluskey, Joseph Bryan, C Nikolopoulou, Christie M. Ballantyne, Fausto Santeusanio, L Pegoraro, M Lee, A Klimenko, S Jaiveer, K. Pettersson-Fernholm, Michael A. Nauck, A Ekbom-Schnell, G Deferrari, Riccardo Schiaffini, S. Pampanelli, Khan Aka., David Hopkins, Maija Wessman, M Kamarinos, Noh J-H., O Ebisui, K McCarroll, Jeppe Sturis, Peter Nowotny, N Gorbenko, Åke Sjöholm, David G. Maggs, A E Halseth, B Cresci, A A Ortiz-Gress, A Korakovouni, O Matejkova, C E Mogensen, C J Lin, Ramon Gomis, H Seaman, C Granier, Yang C-H., F Assah, O Sanchez, Fausto Machicao, Peter G. Morris, Alberto Ortiz, A Giardinelli, D Bracaglia, A Gonzalo, S Pavlatos, Andreas Lechner, F Canovic, L Sjolind, Allan Vaag, Birgitte Bruun Nielsen, David A. Ziegler, Vito Lampasona, R Gershoni-Baruch, A. Dei Cas, H Renz, E Mena, Matthew Waltham, Kim D-M., H Levanen, D D Mick, Valentina Alexandrovna Peterkova, E Meskhishvili, Sarah Nutland, R Bustani, John R. Lindsay, M Christoforidou, A Abicht, E Harno, K Cyganek, A Fitchet, S Neelotpol, P Nikishin, P Serradas, J Hinrichsen, M Halvorson, M Chovatia, B Voet, Jinny Willis, E Parretti, M Haslbeck, M Wellard, L Teng, Julio Wainstein, J S Fischer, K. Lalic, D Roggenland, I Gich, R Anwar, Maurizio Cassader, D Serota, X J Li, R J Schotzinger, Vilmundur Gudnason, Björn Zethelius, S A Wootton, W Andrzejewski, R Rezsohazy, R Gao, T Klimentova, T Mazurek, I Bruckner, C Dohrmann, R E James, G daSilva Xavier, Kim S-Y., A Dorca, Stuart J. Pocock, Terri J. Allen, I Giovos, P B Parab, N H Andersen, P Fotinakis, Miriam Cnop, H Lee, Norbert Tennagels, Omorodola I. Abatan, F Ailett, I. Lager, D Manzella, H Hut, Larry A. Distiller, G Lip, Lim S-K., Rong Zhang, T Tsuno, Steen Knudsen, M. Bajardi, Manuel Benito, Dai Sugimoto, Melvin J. Prince, D W Dunstan, D Rankins, K A Majali, G Ozansoy, Isabella Russo, S Uçak, G Annuzzi, R Talar-Wojnarowska, K Lange, S Neugebauer-Baba, Campbell H. Thompson, Eric Renard, P. D. Mountjoy, Z Morrison, Elizabeth A. Davis, Franco Cavallo, C Corvaja, R Antuña, Craig John Currie, H Linnebjerg, He Y-L., A J Palmer, Mariola R. Chacón, H Malinska, M. Jones, R Lichnovská, K Mandes, Paolo Tessari, T Mokhort, A Laina, H. L. Y. Chan, I Schmidt, R Banks, Richard G. IJzerman, L Ksinantova, G Setti, H Vaudry, A Gallo, V Spallone, Chen J-W., Thomas Danne, A Chong, M Hallschmid, S Aczel, S Hulme, N Islam, M Hosoi, P M Ternan, P Di Bartolo, N Bishara, T Shibasaki, Martin A. Osterhoff, Im S-S., M Jecht, T Hamaguchi, S Mattera, K Ways, Elizabeth Northam, U Rajala, Reinhard W. Holl, L Yang, S Panaiotopoulos, K Horvath, R Kluge, Thora B. Bodvarsdottir, Y Dong, Irene Alemanno, C McDougall, Reimar W. Thomsen, M Campbell, W Rabl, John Öhrvik, Yuichiro Yamada, Paola Ungaro, W Benzer, Mike Sampson, Roberto Trevisan, R G Radu, Aas A-M., P E Lobo, Ricardo Scott, S M Son, Josephine M. Forbes, T A Hillier, K L Wyne, Louis L. Nguyen, J Farmer, M H Tan, Kwon H-S., J Yang, L Sandvik, Franco Folli, A K Jenum, M Nguyen, W Pratipanawatr, A L Frederiksen, Rebecca Smith, Lee H-J., A Schäfer, C Manuelli, G S Denver, T Vukovich, B Maceira, K Matsumoto, K. Chokkalingam, Nurcan Üçeyler, P Modi, Timothy M. Morgan, S Mertens, B M Singh, Michaela Riedl, K Iso, C Cucurullo, G. F. Bottazzo, M Calvani, K Hur, J Wetzels, Kazuhiro Takahashi, Y Aso, H Stammer, M G Masding, Fitsum Guebre-Egziabher, J L González-Sánchez, L Armstrong, Alberto Maran, Peter G.F. Swift, S S Popovic, J Starczynski, E Vitacolonna, Luigi Laviola, R W Gelling, Marina Cardellini, D Barilla, Rosa de Diego Martínez, W H Landschulz, Anne Mette Rosenfalck, R K Wong, Kevin E. Schneider, K Peros, Giuseppe Nanni, F Zhang, I Rákóczi, T Iburi, M Nakhjavani, X Q Zhang, S Tournis, Per Lav Madsen, Graham A. Hitman, A. Tura, K Laubner, N D Kostic, Lawrence M. Dolan, R. Sinha Roy, J A Wagner, J. Tuomilehto, J Hauptman, M Abdel-Ghany, D Lacombe, Toralph Ruge, Johannes A Maassen, Triantafyllos Didangelos, K Sasaki, I Argüelles, Klaus Levin, C Popow, Emanuel Christ, R Chetty, L Baillet-Blanco, Jo-Ann Salmon, T Mine, James L. Trevaskis, I Franke, J Gorski, E A Andrianova, A Dayan, A Caballero, Aleksandra Gilis-Januszewska, M Yasujima, Z Kasalová, C.D.A. Stehouwer, F. K. Gorus, G A Nichols, A Glowania, David P. Strachan, P Fredlund, N. F. da Silva, P Reboldi, M Sausbier, K H Groenier, G Stuccio, N Guttman, K R Ahmed, A D Ristic, T Kapellen, J Coutcher, Aldo V. Greco, Oswald Wagner, A Zagayko, Maria Alevizaki, B B Zhang, W F Ferris, Jenny Fredriksson, Lois Jovanovic, J Hänninen, R De Giglio, Kazuo Yagui, O Potterat, P Hamliton, R E Scranton, B Mankovsky, A Stylianou, B Fellström, Abdel-Wahab Yha., M Kitagawa, Katherine L. Baldock, F R Johnson, F Baigts, S D'Addato, F J Sanz, A Mistry, S D Wise, T Pratipanawatr, U R Fölsch, James R.C. Parkinson, Claudia Sommer, C Park, F E Griffiths, M L Martí, R Demirtunc, S Taniguchi, J Lundkvist, T Siegmund, Juan Sztajzel, C Dienesch, F Baumgartner, L Scalone, T M Mckolanis, K Otake, Ullrik Pedersen-Bjergaard, T M Vriesendorp, Michael B. Wheeler, Henry Schmitt, Peter Hovind, S Lange, Stephane Roze, L. Van Gaal, B Klaproth, Anthony E. Civitarese, D Eckland, A Dagar, D F Hopkins, Kari Stefansson, C Gonzalez-Yanes, B Meyboom-de Jong, D. J. Betteridge, K Buhling, M Crepaldi, Ana M. Wägner, L Renna, L Volpe, R McBride, V Corbo, E O Brennesvik, R P Hayes, R Abdollahnia, G Viviani, C F Liew, Francisco Pérez-Bravo, Jeffrey Baron, Brian M. Frier, H H Samira, D Szentendrei, K. J. Schjoedt, W K Waldhäusl, D Gniuli, D Zou, G Tschank, V Urbančič, A L Nolan, Albertini J-P., J Malcomson, M Larbig, C Cheyssac, K Aurich, C M Kesson, S Heller, Maija E. Miettinen, R F Luco, Adrian J. Cameron, Luigi Mattiello, Z. Metelko, X E Zhang, M Parramón, I. G. 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Jensen, A D'Avanzo, J Monaghan, K P Yeo, Guivarch P-H., B Bauduceau, D Weghuber, P Tatti, J Ybarra, S Gwozdziewiczová, E Gasparini, B Saltin, Charlotte Granhall, Howard Leventhal, R Marin, M Tumiati, Cicero Afg., L Csémy, B Berger, S Mikros, D Dall'Asta, M Shahmanesh, Y G Vasiljev, F Potthoff, H S Randeva, G De Berardis, J O Logan, K Warncke, P Uitterlinden, E Rehring, K Gilmore, K Shankhdhar, V V Bojko, M Vahatalo, E A Korolyova, D Wiemann, P G Lankisch, D Hendrie, F Galtier, M Rybarczyk, Gisela Dahlquist, N N Rudovich, G Stein, A Liebl, F Tan, A Westerlund, S Gronemann, I Franklin, Jonathan A. Prince, Peter Arner, E Skliros, T. Sparre, M Vigas, Maddalena Trombetta, L. Bjerre Knudsen, A C Sima, I Dubroca, Alastair Gray, I Weets, R Ferraresi, Schauer Ujw., E. Leinonen, S Corazza, Jonathan Levy, P K Prakash, R Guzder, S. Barnhill, John Blangero, J Herreros, G. de Vries, Cheng Ptw., A Macías-Batista, K. 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Hansen, T Watanabe, Gang Hu, Malik Rja., T Kennedy-Martin, Ulla M Smidt, J.M. Dekker, A A Fisher, H Liu, R E Pratley, B Sun, C Fledelius, J F Raposo, R Langham, Ahn S-Y., B R Waterhouse, Shaoping Deng, W Ricart, S V Melnichenko, Henrike Sell, M. Tomalino, N Takeda, Paola Massucco, A Harlan, W Henrich, C D Byrne, R Junik, Khalid Hussain, D Pop Gorceva, Torben Hansen, C Ritterath, K Ogawa, D V Phan, Bradley S Metcalf, Robb E. Moses, Juan P. Frias, Hitoshi Ishii, C Brisard, P Wolkow, H H Maurer, Ingo Rustenbeck, Juris J. Meier, Octavian Savu, S D Lin, V B Bregovski, A Fox, S Cicala, M. Koenen, L Vignati, O de Divitiis, Constantin Ionescu-Tirgoviste, Kilian Rittig, J Song, Riccardo Candido, F Cohen-Boulakia, U Shankhdhar, P Jahan, Antonio Tiengo, E Liepinsh, C Álvarez, Sigurd Lenzen, James E. 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Tryfinopoulou, K, Melidonis, A, Nikolopoulou, C, Harley, K, Ryder, R, De, P, Vannieuwenhoven, F, Rossing, K, Oliver, N, Goldschmeding, R, Jacobsen, P, Tan, F, Liew, S, Mukherjee, J, Lim, P, Fröjdö, S, Sjölind, L, Parkkonen, M, Mäkinen, V, Tikellis, C, Nieuwenhoven, F, Macisaac, R, Tsalamandris, C, Mcneil, K, Panaiotopoulos, S, Smith, T, Ho, M, Matthews, P, Jerums, G, Hut, H, Van Den Meiracker, A, Nakhjavani, M, Behjati, J, Esteghamati, A, Esfahanian, F, Aghamohamadzadeh, N, Abbasi, M, Kohnert, K, Zander, E, Krabbe, S, Stehouwer, C, Schalkwijk, C, Krarup Hansen, T, Teppo, A, Ebeling, P, Abdella, N, Mojiminiyi, O, Al Dahi, W, Al Mohammedi, H, Al Jebely, S, Neugebauer baba, S, Baba, T, Ohashi, H, Nakajima, S, Hesselmann, C, Watanabe, T, Nargis, M, Zaid, R, Voronko, O, Tchugunova, L, Vikulova, O, Nosikov, V, Liu, L, Zheng, T, Li, M, Zhang, R, Xiang, K, Hadjadj, S, Jeunemaitre, X, Vervoort, G, Veldman, B, Berden, J, Wetzels, J, Singh, B, Holland, M, Baskar, V, Oh, J, Seo, J, Choi, K, Baik, S, Choi, D, Kim, N, Matsumoto, S, Suetsugu, M, Matsutomo, R, Pisarczyk wiza, D, Banaszak, A, Wysocki, H, Usui, H, Shikata, K, Okada, S, Ogawa, D, Yozai, K, Kido, Y, Nagase, R, Ohga, S, Tone, A, Sasaki, M, Wada, J, Unno, Y, Horiuchi, S, Mclennan, S, Kamarinos, M, Waltham, M, Dy, V, Yue, D, Zdychova, J, Komers, R, Cresci, B, Giannini, S, Manuelli, C, Giunti, S, Pinach, S, Ianni Palarchio, A, Arnaldi, L, Vittone, F, Camussi, G, Cavallo Perin, P, Gruden, G, Marshall, S, Jones, S, White, K, Brizzi, M, Dentelli, P, Rosso, A, Calvi, C, Gambino, R, Cassader, M, Salvidio, G, Deferrari, G, Pegoraro, L, Pagano, G, Cavallo perin, P, Oates, R, Ellery, C, Beebe, D, Coutcher, J, Qian, Y, Lowe, V, Appleton, T, Raunig, D, O'Neil, S, Mylari, B, Amazonas, R, Fujita, A, Doi, A, Matsuno, S, Okamoto, K, Matsumoto, E, Furuta, H, Nishi, M, Tsuno, T, Taniguchi, H, Bessho, H, Wasén, E, Isoaho, R, Mattila, K, Vahlberg, T, Kivelä, S, Irjala, K, Rigalleau, V, Lasseur, C, Perlemoine, C, Barthes, N, Raffaitin, C, Chauveau, P, Combe, C, Baillet blanco, L, Beauvieux, M, Gin, H, Heinrich, S, Steiner, T, Ott, U, Holdass, H, Fellström, B, Jardine, A, Staffler, B, Logan, J, Gimpelewicz, C, Stanciu, C, Pena, C, Serafinceanu, C, González posada, J, Hernández, D, Pérez tamajó, L, Ló, A, Herná Alarcó, M, Meneses, M, Barsotti, M, Rizzo, G, Schmauss, S, Havrdova, T, Saudek, F, Boucek, P, Adamec, M, Invitti, C, Gilardini, L, Parati, G, Mazzilli, G, Pontiggia, B, Sartorio, A, Lutgers, H, Groenier, K, Zasadzinska, G, Saryusz wolska, M, Kurktschiev, D, Majdrakova, I, Varbanova, T, Todorova, B, Bajo martinez, A, Bernal, E, Sanchez, O, Ugalde canitrot, A, Sanchez largo, E, Coca robinot, D, Fabregate, R, Calbacho, M, Marquez, J, Saban ruiz, J, Penesova, A, Cizmarova, E, Blazicek, P, De Jongh, R, Serné, E, Ijzerman, R, De Vries, G, Andersen, N, Knudsen, S, Helleberg, K, Mogensen, C, Waluś, M, Idzior waluś, B, Sztefko, K, Cieślik, G, Fedak, D, Wozniakiewicz, E, Lin, S, Guo, M, Lin, C, Liu, X, Francisco, M, Rodriguez rosas, H, Peiró martinez, I, Macías batista, A, Harte, A, Rodriguez cuenca, S, Valsamakis, G, Chetty, R, Anderson, L, Roca, P, Matyka, K, Lasalle, J, Hershon, K, Berman, L, Gibson, E, Gillen, D, Maroni, J, Simmons, D, Hiukka, A, Forder, P, Leinonen, E, Hilden, H, Fruchart, J, Keech, A, Farnier, M, Freeman, M, Macdonell, G, Perevozskaya, I, Mitchel, Y, Gumbiner, B, Didangelos, T, Athyros, V, Mikhailidis, D, Papageorgiou, A, Bouloukos, V, Pehlivanidis, A, Symeonidis, A, Elisaf, M, Mckenney, J, Insull, W, Lewin, A, Maccubbin, D, Kush, D, Schuster, H, Barter, P, Stender, S, Bonnet, J, Morrell, J, Watkins, C, Kallend, D, Stalenhoef, A, Ballantyne, C, Murin, J, Tonstad, S, Rose, H, Wilpshaar, W, Jenkins, A, Karschimkus, C, Dragicevic, G, Rowley, K, Wolthers, T, Best, J, Voet, B, Murdoch, S, Marcovina, S, Brunzell, J, Caparevic, Z, Kostic, N, Ilic, S, Sartore, G, Piarulli, F, Cantaro, S, Reitano, R, Fiore, C, Marin, R, Bassan, S, Manzato, E, Fedele, D, Solini, A, Santini, E, Thornalley, P, Babaei jadidi, R, Karachalias, N, Kupich, C, Ahmed, N, Fowler, A, Baker, A, Starczynski, J, O'Hare, P, Szepietowska, B, Szelachowska, M, Puch, U, Glebocka, A, Quinn, D, Mcternan, C, Bonser, R, Idzior walus, B, Woźniakiewicz, E, Dimitriou, K, Apostolou, O, Kontela, E, Devangelio, E, Gould, E, Serri, O, Roussin, A, Buithieu, J, Mamputu, J, Renier, G, Giordanetti, S, De Amici, E, Poggi, G, Turpini, C, Fratino, P, Garzaniti, A, Banu, I, Paries, J, Roman, G, Negrean, M, Bala, C, Nita, C, Kistorp, C, Gustafsson, F, Chong, A, Lip, G, Galatius, S, Ari, N, Sahilli, M, Ceylan isık, A, Ozansoy, G, Karasu yilmaz, C, Matteucci, E, Rosada, J, Pallini, M, Evangelista, I, Cassetti, G, Giusti, C, Giampietro, O, Capaldo, B, Galderisi, M, Cicala, S, Turco, A, Imbroinise, A, Nosso, G, D'Errico, A, De Divitiis, O, Klimontov, V, Korolyova, E, Jeltova, L, Bondar, I, Tarkun, I, Arslan, B, Canturk, Z, Tarkun, P, Agacdiken, A, Komsuoglu, B, Méneveau, N, Pierre justin, E, Alsayed, M, Sabbah, R, Paulin, S, Marcu, S, Tauveron, I, Zimmermann, C, Schiele, F, Seronde, M, Vautrin, P, Lusson, J, Thieblot, P, Bernard, Y, Mistry, A, Pye, M, Peovska, I, Maksimovic Pavlovic, J, Vavlukis, M, Pop Gorceva, D, Bosevski, M, Scognamiglio, R, Negut, C, De Kreutzenberg, S, Madonna, R, De Caterina, R, Willerson, J, Geng, Y, Vahsen, S, Ledwig, D, Ramrath, S, Frantz, S, Schmidt, I, Calvillo, L, Dienesch, C, Elbing, I, Bischoff, H, Ertl, G, Bauersachs, J, Davydov, A, Mkrtum'Yan, A, Baranova, L, Ikeda, Y, Suehiro, T, Osaki, F, Ota, K, Arii, K, Kumon, Y, Hashimoto, K, Doney, A, Morris, A, Palmer, C, Byun, S, Doo, H, Pagnin, E, Calo, L, Fadini, G, Kubaszek, A, Chai, S, Chai, Q, Rasmussen, L, Ledet, T, Wogensen, L, Lengyel, C, Varró, A, Virág, L, Magyar, J, Bíró, T, Jost, N, Skoumal, R, Nánási, P, Tóth, M, Horkay, F, Papp, J, Zacharopoulou, O, Athanaselis, S, Tsokos, N, Doupis, J, Psallas, M, Cokkinos, D, Pavlatos, S, Liatis, S, Akhobadze, T, Dzneladze, L, Samarguliani, I, Taskiran, M, Rasmussen, V, Jensen, G, Fisher, A, Petrovsky, N, Srikusalanukul, W, Budge, M, Trifunovic zamaklar, D, Zivkovic, M, Jelic, V, Vukomanovic, G, Ristic, A, Seferovic, P, Costa, J, Duarte, S, Manley, S, Sailesh, S, Venkataraman, A, Haider, Y, Groza, I, Oprean, M, Ardelean, A, Morosanu, A, Darkow, T, Vanderplas, A, Mamas, M, Mcelduff, P, Burns, J, Edwards, R, Fitchet, A, Young, R, Gibson, J, Lichiardopol, R, Niculescu, N, Totora, A, Pencea, C, Tomescu, I, Cinteza, M, Manicardi, V, Coscelli, C, Navazio, A, Catellani, E, Michelini, M, Dall'Asta, D, Guberti, A, Piazza, A, Gasparini, E, Pantaleoni, M, Guiducci, U, Manari, A, Sejil, S, Janand delenne, B, Avierinos, J, Habib, G, Labastie, N, Vague, P, Lassmann vague, V, Luźniak, P, Tatoń, J, Wojciechowska Luźniak, A, Zairis, M, Lyras, A, Patsourakos, N, Tsirimbis, V, Foussas, S, Lupón, J, Urrutia, A, Herreros, J, González, B, Coll, R, Altimir, S, Prats, M, Valle, V, Abreu padí, C, Rábago, G, Ivanova, L, Brasacchio, D, Harno, E, Keenan, A, Li, H, Lu, Z, Ke, L, Liu, H, Jeong, I, Chae, M, Choi, M, Yoo, H, Kim, C, Yun, M, Na, M, Kang, Y, Kong, O, Son, S, Kim, I, Tanaka, N, Hosoi, M, Matsuyama, Y, Fukumoto, M, Yamakita, T, Yoshioka, K, Ishii, T, Sato, T, Fujii, S, Aoki, T, Shibata, T, Mizutani, N, Suzuki, J, Fowelin, J, Samuelsson, P, Brandrup wogsen, G, Okumura, K, Tokmakova, A, Staroverova, D, Antcieferov, M, Shutichina, I, Kuntchevich, G, Vriesendorp, T, Morélis, Q, Legemate, D, Schaper, F, Mainas, E, Gkioulmpasanis, I, Panagiotou, I, Vassilikos, G, Skorda, L, Sidira, M, Christoforidou, M, Alaveras, A, Artikis, V, Evdemon, E, Lechleitner, M, Koch, T, Ebenbichler, C, Sturm, W, Moretti, L, Moruzzo, D, Boldrini, E, Pandolfo, C, Kameyama, M, Iwasa, R, Cho, M, Nam, J, Huh, K, Kaplar, M, Paragh, G, Erdei, A, Csongradi, E, Garai, I, Varga, J, Galuska, L, Udvardy, M, Higa, M, Kaneko, Y, Hiroi, N, Koziarska, D, Nowacki, P, Majkowska, L, Luzniak, P, Wojciechowska luźniak, A, Tushuizen, M, Nieuwland, R, Snoeck, D, Sturk, A, Diamant, M, Aguiar, L, Bahia, L, Villela, N, Laflor, C, Conde, C, Bottino, D, Dorigo, D, Bouskela, E, Pu, S, Luo, Z, Lam, K, Dan, Q, Xu, A, Shen, J, Cheng, K, Xu, J, Thamer, C, Stefan, N, Haap, M, Heller, E, Tschritter, O, De Prado, A, Ortiz, A, Ybarra, J, Gich, I, Pou, J, Ehren, M, Roggenland, D, Reinsen, B, Klein, H, Rittig, K, Stock, J, Kocher, B, Balletshofer, B, Shon, H, Chung, D, Nakatani, Y, Matsuhisa, M, Kaneto, H, Hatazaki, M, Yoshiuchi, K, Katakami, N, Kawamori, D, Ohtoshi, K, Sakamoto, K, Matsuoka, T, Ozawa, K, Ogawa, S, Hori, M, Yamasaki, Y, Zitouni, K, Harry, D, Nourooz zadeh, J, Earle, K, Olesen, P, Franco, L, Corvaja, C, Semplicini, A, Ceylan işık, A, Arı, N, Rösen, P, Lee, I, Park, K, Jung, E, Shin, D, Jo, S, Obuobie, K, Prakash, P, Hanna, F, Lazarus, J, Varadhan, L, Gurushankar, J, James, D, Sheikh, S, Gaede, P, Zou, D, Vilarrasa, N, Perez maraver, M, Mena, E, Perez, D, Setti, G, Buckingham, R, Urbančič, V, Stefanovska, A, Bernjak, A, Ažman juvan, K, Kocijančič, A, Glowania, A, Filters, T, Fosmark, D, Torjesen, P, Kilhovd, B, Berg, T, Sandvik, L, Hanssen, K, Mentink, C, Donchenko, G, Stepanenko, S, Maingrette, F, Deng, H, Lindenmair, A, Freudenthaler, A, Baumgartner parzer, S, Nizheradze, K, Khoruzhenko, A, Tronko, N, Sheu, W, Ou, H, Shen, H, Lin, T, Wu, H, Yang, C, Mogylnytska, L, Schmoelzer, I, Davies, J, Band, M, Struthers, A, Prázný, M, Škrha, J, Kasalová, Z, Neelotpol, S, Jahan, P, Kauschke, S, Harrop, C, Schäfer, A, Widder, J, Eigenthaler, M, Walter, U, Uchimura, I, Ikebukuro, M, Kaibara, M, Hirata, M, Helal, R, Pervin, F, Yang, X, Jansson, P, Nagaev, I, Jack, M, Carvalho, E, Sunnerhagen, K, Cam, M, Cushman, S, Smith, U, Creely, S, Farmer, J, Gustafson, B, Kusminski, C, Krusinova, E, Wohl, P, Klementova, M, Lanska, V, Mcdougall, C, Kelly, I, Abbas, Z, Lutale, J, Archibald, L, Karunajeewa, H, Stingemore, N, Stuccio, G, Mcgechie, D, Muller, L, Hak, E, Goudzwaard, W, Montorsi, F, Homering, M, Sprenger, K, Goldstein, I, Asnaghi, V, Ferrari, G, Rastaldi, M, Gabellini, D, Dell'Antonio, G, Maestroni, A, Ruggieri, D, Luzi, L, Piemonti, L, Zerbini, G, Anafaroglu, I, Tutuncu, N, Sultana, M, Siddiqua, N, Iwasaki, T, Nakajima, A, Yoneda, M, Mukasa, K, Tanaka, S, and Sekihara, H
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0303 health sciences ,medicine.medical_specialty ,business.industry ,EASD ,Endocrinology, Diabetes and Metabolism ,Human physiology ,medicine.disease ,03 medical and health sciences ,0302 clinical medicine ,Diabetes mellitus ,Family medicine ,Internal Medicine ,Medicine ,business ,030217 neurology & neurosurgery ,030304 developmental biology - Published
- 2004
15. Thermodynamically distinct high and low affinity states of the A(1) adenosine receptor induced by G protein coupling and guanine nucleotide ligation states of G proteins
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A, Lorenzen, L, Guerra, F, Campi, H, Lang, U, Schwabe, and P A, Borea
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Receptors, Purinergic P1 ,Brain ,In Vitro Techniques ,Ligands ,Guanosine Diphosphate ,Guanine Nucleotides ,Rats ,Prosencephalon ,Purinergic P1 Receptor Antagonists ,GTP-Binding Proteins ,Xanthines ,Papers ,Purinergic P1 Receptor Agonists ,Animals ,Thermodynamics - Abstract
The influence of the receptor-G protein coupling state and the guanine nucleotide ligation state of the G protein on the binding mechanism of A(1) adenosine receptor ligands has been investigated in [(3)H]-1,3-dipropyl-8-cyclopentylxanthine ([(3)H]-DPCPX) binding studies in rat brain membranes. Thermodynamic parameters of binding of A(1) adenosine receptor ligands of different intrinsic activities were determined in the absence or presence of GDP and compared to the binding mechanism after receptor-G protein uncoupling. In agreement with previous studies, it was found that xanthine and non-xanthine antagonists showed an enthalpy- or enthalpy- and entropy-driven binding mechanism under all conditions. In contrast to antagonists, the binding mechanism of agonists was strongly affected by the G protein coupling state or the absence or presence of guanine nucleotides. Binding of full and partial agonists to the high-affinity state of the A(1) receptor was entropy-driven in the absence of GDP, and a good correlation between intrinsic activities and the contribution of entropy was observed. In the absence of GDP, binding of full and partial agonists and antagonists to the high affinity state of the receptor was thermodynamically discriminated. In contrast, no such discrimination was found in the presence of GDP. The binding mechanism of agonists to the low-affinity state of the receptor was identical to that of antagonists only after uncoupling of the receptor from G proteins by pretreatment with N-ethylmaleimide or guanosine-5'-(gamma-thio)-triphosphate (GTPgammaS). These results indicate the existence of two thermodynamically distinct high- and low-affinity states of the A(1) adenosine receptor.
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- 2000
16. Endocrine-disrupting agents on healthy human tissues
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G, Paganetto, F, Campi, K, Varani, A, Piffanelli, G, Giovannini, and P A, Borea
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Male ,Estradiol ,Receptors, Retinoic Acid ,Uterus ,Phthalic Acids ,Prostate ,Tretinoin ,Metribolone ,Tritium ,Binding, Competitive ,Receptors, Estrogen ,Pregnenediones ,Receptors, Androgen ,Culture Techniques ,Androgen Receptor Antagonists ,Humans ,Environmental Pollutants ,Female ,Receptors, Progesterone ,Testosterone Congeners - Abstract
A vast number of substances have been suggested as possibly contributing to perturbation of the endocrine system. Several have been tested with different approaches ranging from yeast expression system of human oestrogenic receptors to human breast cancer cells assays. Surprisingly, no inhibition-binding experiments to steroid receptors on healthy human tissue have been performed so far. Our study provides inhibition binding experiments to oestrogens, progesterone, testosterone and retinoic acid receptors in prostate and uterine human tissue of organochlorine pesticides, phthalate esters, oestrogenic constituents derived from plants and phenol derivates. Affinities of significant extent of phthalates on oestrogenic, progestinic and androgenic receptors have not been detected. As for retinoic acid receptors, mono(2-ethylexyl)phthalate provokes a notable reduction of the binding of the tritiated retinoic acid, phtalic acid ethyl-n-butyl ester and 4-octylphenol show an affinity comparable to that of isoflavonoid genistein, whereas 4-nonylphenol reduces the binding of retinoic acid in prostate.
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- 2000
17. Seeking for the determinants of renal function loss after robot-assisted partial nephrectomy: what is below the tip of the iceberg.
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Di Maida, Fabrizio, Grosso, Antonio Andrea, Lambertini, Luca, Nardoni, Samuele, Giudici, Sofia, Paganelli, Daniele, Coco, Simone, and Minervini, Andrea
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- 2024
- Full Text
- View/download PDF
18. Hemiarthroplasty of the shoulder. Clinical experience in 18 cases treated by the Neer monoblock prosthesis
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G, Porcellini, F, Campi, G, Baccarani, and R, Galassi
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Male ,Shoulder Joint ,Joint Prosthesis ,Humans ,Female ,Middle Aged ,Prosthesis Design ,Aged - Abstract
The authors report the results of 18 hemiarthroplasties of the shoulder performed between 1990 and 1994 using the Neer II monoblock prosthesis, emphasizing the technical and surgical problems encountered. The patients treated numbered 13 for traumatic pathology (acute fractures: 7; sequelae of fracture of the proximal epiphysis of the humerus: 6), and 5 for degenerative lesions (arthrosis: 3; rheumatoid arthritis: 2). An evaluation of the results was based on the Constant method and isokinetic testing. Results based on follow-up obtained after 2 to 6 years were satisfactory in 83% of the cases.
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- 1999
19. Conservative surgical approach versus non-surgical management for diabetic neuropathic foot ulcers: a randomized trial
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A, Piaggesi, E, Schipani, F, Campi, M, Romanelli, F, Baccetti, C, Arvia, and R, Navalesi
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Wound Healing ,Diabetes Mellitus, Type 1 ,Time Factors ,Diabetes Mellitus, Type 2 ,Diabetic Neuropathies ,Foot ,Patient Satisfaction ,Recurrence ,Humans ,Middle Aged ,Patient Acceptance of Health Care ,Diabetic Foot ,Aged - Abstract
To test the efficacy of surgical treatment of non-infected neuropathic foot ulcers compared to conventional non-surgical management, a group of diabetic outpatients attending our diabetic foot clinic were studied. All patients who came to the clinic for the first time from January to December 1995 inclusive with an uncomplicated neuropathic ulcer were randomized into two groups. Group A received conservative treatment, consisting of relief of weight-bearing, regular dressings; group B underwent surgical excision, eventual debridement or removal of bone segments underlying the lesion and surgical closure. Healing rate, healing time, prevalence of infection, relapse during a 6-month period following intervention and subjective discomfort were assessed. Twenty-four ulcers in 21 patients were treated in group A (17 Type 2 DM/3 Type 1 DM, age 63.24 +/- 13.46 yr, duration of diabetes 18.2 +/- 8.41 yr, HbA1c 9.5 +/- 3.8%) and 22 ulcers in 21 patients in group B (19 Type 2 DM/2 Type 1 DM, age 65.53 +/- 9.87yr, duration of diabetes 16.84 +/- 10.61 yr; HbA1c 8.9 +/- 2.2%). Healing rate was lower (79.2% = 19/24 ulcers) in group A than in group B (95.5% = 21/22 ulcers; p0.05), and healing time was longer (128.9 +/- 86.60 days vs 46.73 +/- 38.94 days; p0.001). Infective complications occurred significantly more often in group A patients (3/24, 12.5% vs 1/22, 4.5%; p0.05), as did relapses of ulcerations (8 vs 3; p0.01). There were only two minor perioperative complications in group B patients. Patients reported a higher degree of satisfaction in group B (p0.01) as well as lower discomfort (p0.05) and restrictions (p0.05). Thus surgical treatment of neuropathic foot ulcers in diabetic patients proved to be an effective approach compared to conventional treatment in terms of healing time, complications, and relapses, and can be safely performed in an outpatient setting.
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- 1998
20. Inhibition of endosomal acidification in normal cells mimics the derangements of cellular insulin and insulin-receptor metabolism observed in non-insulin-dependent diabetes mellitus
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F. Campi, R. Maggiorelli, E. Merola, P Cecchetti, A.M. Ciccarone, L. Benzi, A. Nardone, G. Di Cianni, and R. Navalesi
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medicine.medical_specialty ,Receptor complex ,Time Factors ,endocrine system diseases ,Endosome ,Endocrinology, Diabetes and Metabolism ,medicine.medical_treatment ,Endosomes ,Biology ,Monocytes ,Cohort Studies ,Iodine Radioisotopes ,Endocrinology ,Reference Values ,Internal medicine ,Diabetes mellitus ,medicine ,Humans ,Insulin ,Monensin ,Receptor ,Pancreatic hormone ,Chromatography, High Pressure Liquid ,Ionophores ,nutritional and metabolic diseases ,Middle Aged ,medicine.disease ,Endocytosis ,Receptor, Insulin ,Insulin receptor ,Endocytic vesicle ,Diabetes Mellitus, Type 2 ,biology.protein ,Protein Binding - Abstract
Dissociation of the insulin-insulin receptor complex plays a crucial role in the processing of both insulin and the insulin receptor, and the acidification of endocytic vesicles may be the mechanism by which internalized insulin is dissociated from its receptor and properly sorted and processed. Internalized insulin-insulin receptor complexes are abnormally processed in cells from patients with non-insulin-dependent diabetes mellitus (NIDDM). Accordingly, to further investigate the mechanisms of the derangements observed in NIDDM cells, we examined the effects of the ionophore monensin, which inhibits endosomal acidification, on the cellular processing of insulin and insulin receptor in monocytes from control subjects (n = 12) and NIDDM patients (n = 14). This study confirms that monocytes from NIDDM patients, compared with cells from normal controls, had reduced binding (P.01), internalization (P.01), and degradation (P.01) of insulin. In addition, the release of intracellular radioactivity was slower (P.01), and recycling of the insulin receptor was inhibited (P.01). Moreover, these defects were associated with a significant (P.01) decrease of dissociation of the internalized insulin-insulin receptor complex. In cells from normal controls, incubation with monensin decreased insulin binding (P.01), but not insulin internalization. High-performance liquid chromatography (HPLC) analysis of intracellular radioactivity showed that after monensin intracellular intact insulin significantly increased (P.01), thus suggesting a decrease of intracellular insulin degradation. Moreover, insulin receptor recycling was completely disrupted. All of these derangements were associated with a significant decrease (P.01) of dissociation of insulin-insulin receptor complexes. On the contrary, in diabetic monocytes, monensin had no significant additional effect on NIDDM-linked alterations. Comparison of the results obtained in cells from NIDDM patients to those found in monensin-treated normal cells demonstrates that NIDDM and monensin gave rise to a superimposable impairment of dissociation of the intracellular insulin-insulin receptor complex, associated with similar abnormal sorting and processing of insulin and its receptor. The only defect present in NIDDM cells but not in monensin-treated cells is the decrease of insulin internalization, which thus seems independent of the action of monensin on the processing of internalized insulin-insulin receptor complex. These results suggest that the impairment of dissociation of the insulin-insulin receptor complex may play a crucial role in the subsequent altered processing of insulin and insulin receptor. Moreover, they raise the question as to a possible similar alteration of the same intracellular mechanism by NIDDM and monensin, and point out that the derangements found in cells from NIDDM patients could be localized within the endosomal apparatus and consist mainly of a defective acidification of its interior.
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- 1997
21. Isokinetic testing to evaluate patients submitted to surgery for the treatment of surgical lesion of the rotator cuff
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G, Porcellini, G, Baccarani, F, Campi, and R, Galassi
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Male ,Rupture ,Time Factors ,Middle Aged ,Aged ,Female ,Follow-Up Studies ,Humans ,Isometric Contraction ,Rotator Cuff ,Shoulder Impingement Syndrome ,Muscle Contraction ,Rotator Cuff Injuries - Abstract
A total of 100 cases surgically treated for rupture of the extra-rotator cuff were evaluated by isokinetic testing. Results were evaluated after a period of time ranging from 1 to 4 years, based on the Constant system, defining the type of lesion of the cuff based on the Snyder classification system, and measuring strength postsurgery using isokinetic testing after 3 and 6 months, and 1 year. Isokinetic testing made it possible to accurately evaluate which patients are capable of obtaining better recovery, and how much time is required for physiotherapy for postoperative rehabilitation, also allowing for correction on an individual basis of any muscular imbalance.
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- 1996
22. Calcific tendinitis of the rotator cuff with trochiteal osteolysis. A rare clinical radiologic complication
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G, Porcellini, F, Campi, and M, Battaglino
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Adult ,Radiography ,Rotator Cuff ,Shoulder Impingement Syndrome ,Calcinosis ,Female ,Humans ,Middle Aged ,Osteolysis ,Tendinopathy - Abstract
Among cases of calcific tendinitis that are unresponsive to any type of non-surgical treatment, the authors report 3 cases, out of a total of 32 submitted to surgery, that presented with an osteolytic cavity filled with calcium salts in the insertional region of the supraspinous tendon. These patients presented with pain that they had been experiencing for an average of 4 years, with acute recurrent episodes. When this pathology can be determined radiographically, early surgery is recommended, considering that any type of non-surgical treatment is destined to fail.
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- 1996
23. [Rotator cuff rupture in the shoulder impingement syndrome. Echography and arthrography: 2 diagnostic methods compared]
- Author
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G, Porcellini, F, Campi, F, de Nicolò, S, Vottari, C, Valbonesi, and E, Arcangeli
- Subjects
Aged, 80 and over ,Male ,Rupture ,Rupture, Spontaneous ,Aged ,Arthrography ,Evaluation Studies as Topic ,Female ,Humans ,Joint Diseases ,Middle Aged ,Pain ,Rotator Cuff ,Shoulder Joint ,Syndrome ,Ultrasonography ,Spontaneous ,80 and over - Abstract
After briefly reviewing the shoulder impingement syndrome, the authors investigate the role of two diagnostic imaging methods, i.e., ultrasonography (US) and arthrography, in demonstrating the typical features of this condition. Over a 15 months' period, 190 patients suffering from shoulder pain were examined with arthrography; 50 of them subsequently underwent acromion plastic surgery and rotator cuff stitching. This study was aimed at comparing US and arthrographic results, applying classifiable criteria to make the most accurate diagnosis of rotator cuff tears. The lack of visibility of the rotator cuff at US was the major and clearest sign of tear (100% of cases). The association between cuff thinning and hypo/hyperechoic damaged focal areas was another major sign (in 76.19% of complete tears and in 14.28% of incomplete tears). Hyperechoic focal areas alone proved to be a false-positive finding in 5 cases, while in 11 of 19 cases normal US patterns were a false-negative finding; in 3 cases other conditions were diagnosed. To conclude, the value of US is emphasized in the screening of the painful shoulder and the use of arthrography is suggested when both clinical tests and US fail to yield enough information for a diagnosis to be made.
- Published
- 1994
24. Tears of the rotator cuff associated with neurologic disorders: a description of two cases
- Author
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G, Porcellini, F, Campi, and E, Brunetti
- Subjects
Aged, 80 and over ,Diagnosis, Differential ,Aged ,Brachial Plexus Neuritis ,Humans ,Male ,Rupture ,Rotator Cuff Injuries ,Diagnosis ,Differential ,80 and over - Abstract
Based on their clinical experience with the two cases described, the authors analyze the association between surgically treatable tear of the rotator cuff and neurologic pathology. A semeiologic sign is emphasized, which may be of help in differential diagnosis involving isolated lesion of the rotator cuff. Furthermore, after a review of the literature, the authors express doubts as to the type of surgical treatment to be carried out.
- Published
- 1994
25. D-3 Upper Limb Functional Evaluation on Baseball Pitchers Through a Portable 3D Tracking System Based on Inertial Sensors
- Author
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Pietro Garofalo, Andrea Pellegrini, Pietro Tonino, F. Campi, Paolo Paladini, Ilaria Parel, Andrea Giovanni Cutti, and Giuseppe Porcellini
- Subjects
Functional evaluation ,medicine.anatomical_structure ,Computer science ,Inertial measurement unit ,3d tracking ,Rehabilitation ,Biomedical Engineering ,Biophysics ,medicine ,Upper limb ,Orthopedics and Sports Medicine ,Simulation - Published
- 2010
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26. Poster Session III, July 15th 2010 —- Abstracts Upper limb functional evaluation on baseball pitchers through a portable 3D tracking system based on inertial sensors
- Author
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AG Cutti, P Garofalo, F. Campi, Andrea Pellegrini, P Palladini, Pietro Tonino, and G Porcellini
- Subjects
musculoskeletal diseases ,Engineering ,medicine.medical_specialty ,Kinematics ,Population ,Baseball ,Session (web analytics) ,Physical medicine and rehabilitation ,Scapula ,Inertial measurement unit ,Injury prevention ,medicine ,Pitching ,education ,Engineering(all) ,Simulation ,Functional evaluation ,education.field_of_study ,business.industry ,Work (physics) ,General Medicine ,Inertial ,medicine.anatomical_structure ,Upper limb ,business - Abstract
Introduction During baseball pitching, the shoulder is constantly exposed to micro-traumatic stress and shoulder injury can potentially end a career. Recently, an upper limb functional evaluation protocol based on MTx (Xsens Technologies B.V., the Netherlands) was developed by INAIL Prostheses Centre (Italy). The aim of this work was to apply the protocol on baseball pitchers, looking for indications to prevent possible shoulder injuries. Methods Three baseball pitchers participated in the study. All the pitchers signed informed consent. The scapulo-humeral rhythm (SHR) and the humero-thoracic external rotation (EXT) were evaluated before and after 60 pitches. The same evaluations were repeated 24 hours later. For each subject, the ROM and pattern of SHR and EXT during each session of measurement (S1, S2, S3) were compared to each other. Results Subject 1 presented consistent ROM in all the degrees of freedom and movements examined, indicating no particular shoulder alterations due to the pitching. Subject 2 presented alterations occurring between S1 and S2, and an improvement in the SHR after 24 hours. Subject 3 showed an improvement between S2 and S3 but evident compensation strategies were maintained after 24 hours. Conclusions Larger population of pitchers are required to confirm the capability of the system to discriminate among different alterations and/or injuries occurring in the players. Moreover, the measurement of the real-time pitching can augment the information about the behavior of the shoulder during training, in terms of performance, repeatability of the movement and injury prevention.
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- 2010
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27. Increased Plasma Manganese Superoxide Dismutase (MnSOD) Levels in Neonates with Severe IRDS
- Author
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F Campi, Paola Papoff, L Ligi, Marcello Orzalesi, F Cerroni, P Colarizi, F Ficuccilli, F Laurenti, A Manna, and G Seganti
- Subjects
medicine.medical_specialty ,Endocrinology ,Chemistry ,Internal medicine ,Pediatrics, Perinatology and Child Health ,medicine ,Manganese Superoxide Dismutase - Published
- 1998
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28. PP-30
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Napoleone Prandini, R. Reverberi, G. Massini, Leo Massari, Luciano Feggi, F. Campi, A. Schiavi, and L. Lodi
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medicine.diagnostic_test ,business.industry ,medicine ,Radiology, Nuclear Medicine and imaging ,General Medicine ,Nuclear medicine ,business ,Scintigraphy - Published
- 1997
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29. Alterations of subcortical structure volume in pediatric bipolar disorder patients with manic or depressive first-episode.
- Author
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Gao, Weijia, Chen, Yue, Cui, Dong, Zhu, Ce, Jiao, Qing, Su, Linyan, Lu, Shaojia, and Yang, Rongwang
- Subjects
GRAY matter (Nerve tissue) ,MAGNETIC resonance imaging ,BIPOLAR disorder ,MANIA ,ANALYSIS of covariance - Abstract
Background: Bipolar disorder may begin as depression or mania, which can affect the treatment and prognosis. The physiological and pathological differences among pediatric bipolar disorder (PBD) patients with different onset symptoms are not clear. The aims of the present study were to investigate subcortical structural alterations in PBD patients with first-episode depressive (PBD-FED) and first-episode manic (PBD-FEM). Methods: A total of 59 individuals including 28 PBD-FED, 13 PBD-FEM, and 18 healthy controls (HCs) underwent high-resolution structural magnetic resonance scans. FreeSurfer 7.2 was used to detect changes in subcortical volumes. Simultaneously, thalamic, hippocampal, and amygdala subregion volumes were compared between the three groups. Results: Analysis of covariance controlling for age, sex, education, and estimated intracranial volume shows third and fourth ventricle enlargement in patients with PBD. Compared with the PBD-FED and HCs, the PBD-FEM group had reduced gray matter volume in the left thalamus, bilateral hippocampus, and right amygdala. Subsequent subregion analyses showed right cortico-amygdaloid transient, bilateral accessory-basal nucleus, left hippocampal tail, right hippocampal head, and body volume reduction in the PBD-FEM group. Conclusions: The present findings provided evidence of decreased subcortical structure in PBD-FEM patients, which might present its trait feature. [ABSTRACT FROM AUTHOR]
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- 2024
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30. Application of the Ikpas intelligent stone removal system to assist percutaneous nephrolithotomy.
- Author
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SONG Jun-feng, YANG Yang, LI Ya-lang, FANG Xiao-dong, DANG Xiao-qing, LI Xuan-pei, and LI Xiao-lou
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- 2024
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31. Smoking behavior is associated with suicidality in individuals with psychosis and bipolar disorder: a systematic quantitative review and meta-analysis.
- Author
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Pietschnig, Jakob, Oberleiter, Sandra, and Köhler, Marcel D.
- Subjects
ATTEMPTED suicide ,BIPOLAR disorder ,PUBLICATION bias ,SMOKING ,PSYCHOSES - Abstract
Smoking behavior has been well-established to be more prevalent in individuals with psychosis and bipolar disorder compared to the general population. However, reports about higher suicide attempt prevalence of smoking compared to non-smoking patients suggest that smoking behavior may contribute to identifying at-risk groups of patients in a comparatively easy manner. In the present systematic quantitative review, we provide meta-analytical evidence on the smoking and suicide attempt link in 22 studies (k = 27 independent samples; N = 11,452) of patients with psychosis and bipolar disorder. We observed a small meaningful effect of smoking on suicide attempts (OR = 1.70; 95% CI [1.48; 1.95]), indicating that smokers have 1.70 the odds of having reported a suicide attempt compared to non-smokers. This effect generalized across diagnosis type (i.e., schizophrenia vs. bipolar spectrum disorder), sample type (i.e., invs. outpatients), and participant sex. However, the observed summary effect appeared somewhat inflated due to publication process-related mechanisms, showing some evidence for effect-inflating publication bias and a decline effect. In all, the presently observed smoking and suicide attempt link appears to be small but meaningful and robust, thus suggesting smoking status represents a useful variable for the identification of at-risk populations for suicide attempts. [ABSTRACT FROM AUTHOR]
- Published
- 2024
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32. Protocols for transitioning to adult mental health services for adolescents with ADHD.
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Roberti, Elisa, Scarpellini, Francesca, Campi, Rita, Giardino, Michele, Zanetti, Michele, Clavenna, Antonio, and Bonati, TransiDEA Group Maurizio
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TRANSITIONAL care ,MENTAL health services ,CHILD services ,ATTENTION-deficit hyperactivity disorder ,HYPERACTIVITY - Abstract
Background: For Attention Deficit/Hyperactivity Disorder (ADHD) youth transitioning from child to adult services, protocols that guide the transition process are essential. While some guidelines are available, they do not always consider the effective workload and scarce resources. In Italy, very few guidelines are currently available, and they do not adhere to common standards, possibly leading to non-uniform use. Methods: The present study analyzes 6 protocols collected from the 21 Italian services for ADHD patients that took part in the TransiDEA (Transitioning in Diabetes, Epilepsy, and ADHD patients) Project. The protocols' content is described, and a comparison with the National Institute for Clinical Health and Excellence (NICE) guidelines is carried out to determine whether the eight NICE fundamental dimensions were present. Results: In line with the NICE guidelines, the dimensions addresses in the 6 analyzed documents are: early transition planning (although with variability in age criteria) (6/6), individualized planning (5/6), and the evaluation of transfer needs (5/6). All protocols also foresee joint meetings between child and adult services. The need to include the families is considered by 4 out of 6 protocols, while monitoring (2/6), and training programs (1/6) are less encompassed. In general, a highly heterogeneous picture emerges in terms of quality and quantity of regulations provided. Conclusions: While some solid points and core elements are in common with international guidelines, the content's variability highlights the need to standardize practices. Finally, future protocols should adhere more to the patients' needs and the resources available to clinicians. [ABSTRACT FROM AUTHOR]
- Published
- 2024
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- View/download PDF
33. Autonomous Building Design for Manufacturing and Assembly: A Systematic Review of Design Application, Challenges, and Opportunities.
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Sadoughi, Arezou, Kouhirostami, Maryam, Kouhirostamkolaei, Mahtab, Qi, Bing, and Costin, Aaron
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INDUSTRIALIZED building ,BUILDING information modeling ,LABOR market ,AUTOMATION ,SUSTAINABLE construction ,FACTORY design & construction ,WALL panels ,INTELLIGENT buildings - Abstract
The growing demand for sustainable and affordable construction, paired with labor shortages, requires more efficient tools and methodologies. Industrialized construction (IC) is one solution that has the ability to address construction efficiency by utilizing techniques such as modularization, construction automation, and building information modeling. One particular aspect of IC is Design for Manufacture and Assembly (DfMA) since the design phase determines up to 80% of the operating costs. However, DfMA is yet to be implemented in the construction industry due to some challenges in DfMA that inhibit full implementation. The majority of construction manufacturers have to regenerate the construction drawings for manufacturing which add substantial time to the schedule. Delays are caused by the lack of coordination of these components, as well as assemblies' connections, compliance with building codes, and other related policies. Although many scholarly manufacturing and assembly works have studied and reviewed various aspects, techniques, and applications of DfMA, none have looked at the design process, tools and methods, or challenges in design automation. Using a systematic literature review, this study reviews the most recent innovative design responses for manufacturing and assemblies, and tools and methods. The study then analyzes the identified challenges of DfMA automation and processes in the existing literature on the construction industry, such as the lack of autonomous design and construction manufacturing. The literature analysis suggests future studies are required to improve DfMA not only as a technique but as a design strategy, particularly during the design process and prior to the production phase. Finally, future directions are provided to lead the next generation of research to advance building construction. Significantly, the results of this research provide an up-to-date status on autonomous DfMA and contribute to the body of knowledge of IC by synthesizing the state-of-the-art of building design automation and methods for manufacture and assembly. Practical Applications: Shifting the construction work from a jobsite to a factory environment and utilizing automation are resolutions to a lack of construction efficiency. Factory automation highly relies on DfMA processes. Automating the manufacturing process itself requires advanced knowledge, particularly DfMA; which is a common term referring to both management and technology that enables designers to ease a product's material selection, cost, and factory production. Studies have addressed the state-of-the-art for DfMA, but none have looked at the design process from the early design stage, tools and methods, and the associated challenges. This paper provides a review of design automation techniques in various thematic categories including (1) design scale, from an entire building scale to a small component like a wall, (2) design parameters like structural strengths and sustainability, (3) building material types, (4) tools and methods, and (5) the challenges for implementation. The provided paper is a fundamental resource for DfMA research in construction manufacturing. Manufacturers, developers, and builders require such a resource to learn more about various aspects of the design process and associated challenges to either improve their production lines or establish new state-of-the-art factories. [ABSTRACT FROM AUTHOR]
- Published
- 2024
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34. Urosepsis in Patients With Urinary Tract Calculi Receiving Surgical Intervention
- Author
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Aphichat Suphathamwit, Assistant Professor
- Published
- 2024
35. Percutaneous nephrolithotomy and laparoscopic surgery efficacy and renal function outcomes for large and complex renal calculi.
- Author
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Pak, Yuriy, Kalyagina, Nina, and Yagudaev, Daniel
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- 2024
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36. Power-Shaping Configurable Microprocessors for IoT Devices.
- Author
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Campi, Fabio
- Published
- 2017
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37. 3D virtual model for robot-assisted partial nephrectomy in highly-complex cases (PADUA ⩾ 10).
- Author
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Grosso, Antonio Andrea, Di Maida, Fabrizio, Lambertini, Luca, Cadenar, Anna, Coco, Simone, Ciaralli, Elena, Salamone, Vincenzo, Vittori, Gianni, Tuccio, Agostino, Mari, Andrea, and Minervini, Andrea
- Subjects
PROPENSITY score matching ,LOGISTIC regression analysis ,SURGICAL robots ,RENAL cancer ,AUGMENTED reality - Abstract
Purpose: To compare two cohorts of patients submitted to robot-assisted partial nephrectomy (RAPN) for highly-complex renal masses (PADUA ⩾ 10) with versus without the use of 3DVMs. Materials and Methods: We screened a prospective consecutive cohort of 152 patients submitted to RAPN with 3DVM and 1264 patients submitted to RAPN without 3DVM between 2019 and 2022. Only PADUA ⩾ 10 cases were considered eligible for analysis. Propensity score matching (PSM) analysis was applied. Primary endpoint was to evaluate whereas RAPNs with 3DVM were superior in terms of functional outcomes at 12-month. Secondary outcomes were to compare perioperative and oncological outcomes. Multivariable logistic regression analyses (MVA) tested the associations of clinically significant eGFR drop and 3DVMs. Subgroups analysis was performed for PAUDA-risk categories. Results: Thirty seven patients for each group were analyzed after PSM. RAPN with 3DVM presented a higher rate of selective/no clamping procedure (32.5% vs 16.2%, p = 0.03) and a higher enucleation rate (43.2% vs 29.8%, p = 0.04). Twelve-month functional preservation performed better within 3DVM group in terms of creatinine serum level (median 1.2 [IQR 1.1–1.4] vs 1.6 [IQR 1.1–1.8], p = 0.03) and eGFR (median 64.6 [IQR 56.2–74.1] vs 52.3 [IQR 49.2–74.1], p = 0.03). MVA confirmed 3DVM as a protective factor for clinically significant eGFR drop in this subgroup of patients. Conclusions: RAPN performed with the use of 3DVM assistance for PADUA ⩾ 10 cases resulted in lower incidence of global ischemia and higher rate of enucleations. The positive impact of such technology was found at 12-month follow-up. [ABSTRACT FROM AUTHOR]
- Published
- 2024
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38. The option of transosseous distal suture placement during minimally invasive Achilles tendon repair for high-risk patients can improve outcomes, however does not prevent re-rupture.
- Author
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Carmont, Michael R., Nilsson-Helander, Katarina, and Carling, Malin
- Abstract
Purpose: Achilles tendon ruptures (ATRs) close to the insertion, in high-level athletes, and in patients at high risk of re-rupture, may be better suited to operative repair. Minimally Invasive Repair (MIR) of the Achilles tendon has excellent outcome and low complication rates. Traditionally MIR has showed lower repair strength, failing due to suture pull-out from the distal tendon stump. The aim of this study was to describe the outcome of ATR patients who received transosseous distal suture placement using a standard technique as a reference. Methods: Following ATR, patients were evaluated for pre-injury activity level, body weight, location of the tear and size of the distal Achilles tendon stump. Patients considered to be at high-risk of re-rupture: Tegner level ≥ 8, body weight ≥ 105Kg and distal ATR, received transosseous (TO) distal suture placement (n = 20) rather than the usual transtendinous (TT) technique (n = 55). Patient reported outcome measures and functional evaluation was performed at 12 months following repair. Results: At 12 months follow up both methods resulted in good median (IQR) Achilles tendon Total Rupture Score TO 83.8 (74-88.3) vs. TT 90 (79–94), low increased relative Achilles Tendon Resting Angle TO -3.5˚ (3.6) vs. TT -3.5˚ (3.3) and mean (SD) Single leg Heel-Rise Height Index TO 88.2% (9.9) vs. TT 85.6% (9.9) (n.s.). There were 4 re-ruptures in the high-risk group and 2 in the group receiving TT distal suture placement. All but one of these were traumatic in nature. The mode of failure following TO distal suture placement was proximal suture pull out. Conclusions: To distal suture placement during minimally-invasive Achilles tendon repair for higher-risk patients can lead to results equivalent to those in lower-risk patients treated with a standard TT MIR technique, except for the re-rupture rate which remained higher. There may be factors that have greater influence on outcome other than suture placement following ATR. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
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39. Incidence of metabolic syndrome in patients with unilateral or bilateral staghorn renal stones and its impact on percutaneous nephrolithotomy outcomes.
- Author
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Shen, Zhonghua, Xie, Linguo, Luo, Di, Xie, Haijie, Chen, Hongyang, and Liu, Chunyu
- Subjects
KIDNEY stones ,PERCUTANEOUS nephrolithotomy ,METABOLIC syndrome ,HEPATORENAL syndrome ,BODY mass index ,COMPUTED tomography - Abstract
Background: To evaluate the incidence of metabolic syndrome (MetS) in patients with unilateral and bilateral staghorn calculi (SC) and evaluate the impact on the outcome of percutaneous nephrolithotomy (PCNL). Methods: The clinical data of patients who underwent PCNL for the treatment of SC between 2019 and 2022 were retrospectively reviewed. SC was divided into unilateral and bilateral. The incidence of MetS was compared between the patients with unilateral SC and the patients with bilateral SC, and the impact on the outcome of PCNL was assessed. Results: A total of 1778 patients underwent PCNL between 2019 and 2022. After screening computed tomography, 379 patients were confirmed to have SC, finally, leaving 310 patients with follow-up and complete data to be included in the study. Eighty-four had bilateral SC and 226 had unilateral SC. The patients with bilateral SC had a significantly higher body mass index and higher rates of complete staghorn stones and metabolic syndrome. Higher body mass index, hypertension, diabetes mellitus, hyperlipidaemia, and MetS were present in 62.58%, 44.84%, 21.94%, 60.65% and 27.42% of all patients, respectively. The number of MetS components remained significantly associated with bilateral SC. Specifically, when the number of MetS components increases from 0 to 3–4, the likelihood of developing bilateral staghorn calculi increases by 21.967 times. Eighty-five patients with MetS(+) had a higher rate of overall complications (number (N)(%), 29 (34.12) vs.33 (14.46), P < 0.001) and a comparable stone-free rate to 225 MetS(-) patients. Multivariable analysis confirmed that hyperlipidaemia (P = 0.044, odds ratio [OR] = 1.991, 95% confidence interval [CI] 1.020–3.888) and MetS (P = 0.005, OR = 2.427, 95% CI 1.316–4.477) were independent risk factors for overall complications. Conclusions: MetS is correlated with the formation of bilateral SC and is the main predictor for complications of PCNL especially for low-grade complications (I-II). [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
40. Space–time characterization of ultrashort laser pulses: A perspective.
- Author
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Alonso, Benjamín, Döpp, Andreas, and Jolly, Spencer W.
- Subjects
ULTRA-short pulsed lasers ,ELECTRIC fields ,DESIGN techniques ,ULTRASHORT laser pulses ,WAVELENGTHS - Abstract
The characterization of ultrashort laser pulses has significantly advanced beyond the standard spatial and temporal diagnostics to now include sophisticated spatio-temporal measurement techniques. In this perspective, we provide an overview of the current state of space–time characterization, discussing the theoretical foundations of ultrashort laser pulses, the various measurement techniques and their design trade-offs, and the challenges and opportunities for future development. We explore the extension of these techniques to different wavelength regimes and delve into the unique challenges posed by the characterization of polarization-structured beams. The potential for data-driven analysis to enhance the information extracted from the measurements is highlighted, along with the need for direct measurement of previously inaccessible field components, such as the longitudinal electric field in tightly focused beams. As these diagnostic tools continue to evolve, we anticipate a future where the intricate space–time structure of light can be analyzed on a routine basis, opening up new frontiers in ultrafast science and technology. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
41. Role of Brain Elastography in the Neonatal Setting: State of the Art of Ultrasonographic Techniques and Future Perspectives.
- Author
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Piersigilli, Fiammetta, Campi, Francesca, Savarese, Immacolata, Iacona, Giulia, Auriti, Cinzia, Dotta, Andrea, Braguglia, Annabella, Garcovich, Matteo, and Bersani, Iliana
- Subjects
ULTRASONIC encephalography ,PATIENT safety ,MEDICAL technology ,ELASTICITY ,ULTRASONIC imaging ,MAGNETIC resonance imaging ,SENSITIVITY & specificity (Statistics) ,CHILDREN - Abstract
Magnetic resonance imaging is currently used in the neonatal setting for assessing features of the neonatal brain. However, its utilization is constrained by logistic, technical, or clinical challenges. Brain elastography is a new research technique which enhances the diagnostic capability of traditional imaging, and can be paired with both ultrasonography and magnetic resonance imaging. In particular, brain elastography adds objective and quantitative information to traditional imaging by detecting differences in tissue elasticity/stiffness, which may represent a surrogate marker of the physiologic and pathologic features of the neonatal brain. To date, very limited experience exists about the use of brain elastography specifically in the neonatal setting. The aim of the present review was to describe the most recent information about the feasibility and diagnostic accuracy of brain ultrasound elastography (USE) in neonates, and to provide information about the possible future applications and perspectives of brain elastography. [ABSTRACT FROM AUTHOR]
- Published
- 2024
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42. Rotator Cuff Arthropathy.
- Author
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Graham, Patrick
- Published
- 2024
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43. Cirugía intrarrenal endoscópica combinada para el tratamiento de nefrolitiasis: una serie local.
- Author
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Krebs, Alfred, Fernández, Mario I., Otaola-Arca, Hugo, Souper, Renato, Mejías, Orlando, Alliende, Cristián, Zambrano, Norman, Catalán, Gabriel, Osorio, Francisco, Barroso, Juan P., Saavedra, Álvaro, and Bustamante, Alberto
- Subjects
KIDNEY stones ,LENGTH of stay in hospitals ,PERCUTANEOUS nephrolithotomy ,URINARY calculi ,TREATMENT effectiveness ,NEPHROSTOMY - Abstract
Copyright of Revista Chilena de Urologia is the property of Sociedad Chilena de Urologia and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2024
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44. Mouse models of chronic lymphocytic leukemia and Richter transformation: what we have learnt and what we are missing.
- Author
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Sabrina Bertilaccio, Maria Teresa and Shih-Shih Chen
- Subjects
RICHTER syndrome ,CHRONIC lymphocytic leukemia ,DIFFUSE large B-cell lymphomas ,REGULATORY T cells ,LABORATORY mice ,CHRONIC leukemia - Abstract
Although the chronic lymphocytic leukemia (CLL) treatment landscape has changed dramatically, unmet clinical needs are emerging, as CLL in many patients does not respond, becomes resistant to treatment, relapses during treatment, or transforms into Richter. In the majority of cases, transformation evolves the original leukemia clone into a diffuse large B-cell lymphoma (DLBCL). Richter transformation (RT) represents a dreadful clinical challenge with limited therapeutic opportunities and scarce preclinical tools. CLL cells are well known to highly depend on survival signals provided by the tumor microenvironment (TME). These signals enhance the frequency of immunosuppressive cells with protumor function, including regulatory CD4+ T cells and tumor-associated macrophages. T cells, on the other hand, exhibit features of exhaustion and profound functional defects. Overall immune dysfunction and immunosuppression are common features of patients with CLL. The interaction between malignant cells and TME cells can occur during different phases of CLL development and transformation. A better understanding of in vivo CLL and RT biology and the availability of adequate mouse models that faithfully recapitulate the progression of CLL and RT within their microenvironments are "conditio sine qua non" to develop successful therapeutic strategies. In this review, we describe the xenograft and genetic-engineered mouse models of CLL and RT, how they helped to elucidate the pathophysiology of the disease progression and transformation, and how they have been and might be instrumental in developing innovative therapeutic approaches to finally eradicate these malignancies. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
45. The research landscape of bipolar disorder in Germany: productive, but underfunded.
- Author
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Eckart, Cindy and Reif, Andreas
- Subjects
BIPOLAR disorder ,BIBLIOMETRICS ,CONCEPTUAL structures ,DRUG therapy ,MENTAL illness - Abstract
Background: The recurrent mental illness bipolar disorder is a major burden on the healthcare system, which underlines the importance of research into this disease. Germany is one of the most productive countries in this research activity. This bibliometric analysis aims to outline the social and conceptual structure of the German research landscape on bipolar disorder over the last decade. Furthermore, we provide a short overview over current public funding. Results: Concerning the social structure, most of the German publications were collaboration projects, both with a national but also international orientation, in the latter case predominantly with countries of the global North. Analysis of the conceptual structure of German research activity identified psychiatric genetics, early recognition of bipolar disorder, neuroimaging, and pharmacological interventions as important topics within the field. In the context of a survey, only few publicly funded research projects were reported, many of which did not exclusively investigate bipolar disorder but followed a transdiagnostic approach. Conclusions: Our bibliometric analysis revealed internationally well-networked German research activities on bipolar disorder. In stark contrast to its high prevalence and correspondingly high financial burden to the healthcare system, current grant support for research on this illness is strikingly low, particularly concerning the development of novel treatments. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
46. Patients with High Pre-Operative Physical Activity Take Longer to Return to Baseline.
- Author
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Redfern, Roberta E., Crawford, David A., Lombardi Jr., Adolph V., Tripuraneni, Krishna R., Van Andel, David C., Anderson, Mike B., and Cholewa, Jason M.
- Subjects
PEDOMETERS ,PHYSICAL activity ,TOTAL hip replacement ,JOINT pain ,PATIENT reported outcome measures - Abstract
Patients with end-stage osteoarthritis are recommended to engage in physical activity (PA) to reduce pain and improve function but may avoid PA due to joint pain. Our goal was to investigate patient-reported outcomes and objective mobility metrics (step counts) in total hip arthroplasty (THA) patients as a function of pre-operative PA levels. In total, 1647 patients enrolled in a multicenter prospective cohort study investigating a smartphone-based care management platform for self-directed rehabilitation that underwent THA and were included in analysis. The entire cohort's step count was divided into quartiles to categorize patients with low, moderate, and high baseline PA. Outcomes including pain, EQ-5D-5L, HOOS JR, and step counts were compared according to activity group by ANOVA. Pre-operative pain scores were lowest, with smallest improvements, in the high-baseline PA group. Low-PA patients demonstrated the greatest improvements in EQ-5D-5L, while changes in EQ-VAS, HOOS JR, and satisfaction were similar between groups. Low- and moderate-PA patients increased physical activity by six weeks, reaching 180% and 114% of pre-operative steps; high-PA patients did not return to full step counts until one-year post-operation. Patients who perform high levels of PA undergoing THA report lower levels of pain and higher function pre-operatively but may appreciate less improvement in PA up to one year post-operatively. These results may be helpful in appropriate counseling of patient expectations prior to surgery. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
47. Safe human–robot collaboration for industrial settings: a survey.
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Li, Weidong, Hu, Yudie, Zhou, Yong, and Pham, Duc Truong
- Subjects
INDUSTRIAL surveys ,INDUSTRIAL robots ,INDUSTRIAL safety ,INDUSTRIALISM ,SAFETY standards - Abstract
Human–robot collaboration (HRC) plays a pivotal role in today's industry by supporting increasingly customised product development. Via HRC, the strengths of humans and robots can be combined to facilitate collaborative jobs within common workplaces to achieve specific industrial goals. Given the significance of safety assurance in HRC, in this survey paper, an update on standards and implementation approaches presented in the latest literature is given to reflect the state-of-the-art of this prominent research topic. First, an overview of safety standards for industrial robots, collaborative robots, and HRC is provided. Then, a survey of various approaches to HRC safety is conducted from two main perspectives, i.e., pre-collision and post-collision, which are further detailed in the aspects of sensing, prediction, learning, planning/replanning, and compliance control. Major characteristics, pros, cons, and applicability of the approaches are analysed. Finally, challenging issues and prospects for the future development of HRC safety are highlighted to provide recommendations for relevant stakeholders to consider when designing HRC-enabled industrial systems. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
48. Intelligent Transport Systems: Analysis of Applications, Security Challenges, and Robust Countermeasures.
- Author
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Alharb, Mada and Alabdulatif, Abdulatif
- Published
- 2024
- Full Text
- View/download PDF
49. URS for de-novo urolithiasis after kidney transplantation: a systematic review of the literature.
- Author
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CERRATO, Clara, NEDBAL, Carlotta, JAHRREISS, Victoria, RIPA, Francesco, DE MARCO, Vincenzo, MONGA, Manoj, HAMEED, Belthangady M., KRONENBERG, Peter, PIETROPAOLO, Amelia, NAIK, Nitesh, and SOMANI, Bhaskar
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- 2024
- Full Text
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50. Application of AI in urolithiasis risk of infection: a scoping review.
- Author
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CAMPOBASSO, Davide, PANIZZI, Matteo, BELLINI, Valentina, FERRETTI, Stefania, AMPARORE, Daniele, CASTELLANI, Daniele, FIORI, Cristian, PULIATTI, Stefano, PIETROPAOLO, Amelia, SOMANI, Bhaskar K., MICAU, Salvatore, PORPIGLIA, Francesco, MAESTRONI, Umberto V., and BIGNAMI, Elena G.
- Published
- 2024
- Full Text
- View/download PDF
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