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1,640 results on '"Esteban, Miguel A."'

2. Multimodal cell atlas of the ageing human skeletal muscle

Author

Lai, Yiwei, Ramírez-Pardo, Ignacio, Isern, Joan, An, Juan, Perdiguero, Eusebio, Serrano, Antonio L., Li, Jinxiu, García-Domínguez, Esther, Segalés, Jessica, Guo, Pengcheng, Lukesova, Vera, Andrés, Eva, Zuo, Jing, Yuan, Yue, Liu, Chuanyu, Viña, José, Doménech-Fernández, Julio, Gómez-Cabrera, Mari Carmen, Song, Yancheng, Liu, Longqi, Xu, Xun, Muñoz-Cánoves, Pura, and Esteban, Miguel A.

Published
2024
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3. A spatiotemporal atlas of cholestatic injury and repair in mice

Author

Wu, Baihua, Shentu, Xinyi, Nan, Haitao, Guo, Pengcheng, Hao, Shijie, Xu, Jiangshan, Shangguan, Shuncheng, Cui, Lei, Cen, Jin, Deng, Qiuting, Wu, Yan, Liu, Chang, Song, Yumo, Lin, Xiumei, Wang, Zhifeng, Yuan, Yue, Ma, Wen, Li, Ronghai, Li, Yikang, Qian, Qiwei, Du, Wensi, Lai, Tingting, Yang, Tao, Liu, Chuanyu, Ma, Xiong, Chen, Ao, Xu, Xun, Lai, Yiwei, Liu, Longqi, Esteban, Miguel A., and Hui, Lijian

Published
2024
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4. A spatiotemporal atlas of mouse liver homeostasis and regeneration

Author

Xu, Jiangshan, Guo, Pengcheng, Hao, Shijie, Shangguan, Shuncheng, Shi, Quan, Volpe, Giacomo, Huang, Keke, Zuo, Jing, An, Juan, Yuan, Yue, Cheng, Mengnan, Deng, Qiuting, Zhang, Xiao, Lai, Guangyao, Nan, Haitao, Wu, Baihua, Shentu, Xinyi, Wu, Liang, Wei, Xiaoyu, Jiang, Yujia, Huang, Xin, Pan, Fengyu, Song, Yumo, Li, Ronghai, Wang, Zhifeng, Liu, Chuanyu, Liu, Shiping, Li, Yuxiang, Yang, Tao, Xu, Zhicheng, Du, Wensi, Li, Ling, Ahmed, Tanveer, You, Kai, Dai, Zhen, Li, Li, Qin, Baoming, Li, Yinxiong, Lai, Liangxue, Qin, Dajiang, Chen, Junling, Fan, Rong, Li, Yongyin, Hou, Jinlin, Ott, Michael, Sharma, Amar Deep, Cantz, Tobias, Schambach, Axel, Kristiansen, Karsten, Hutchins, Andrew P., Göttgens, Berthold, Maxwell, Patrick H., Hui, Lijian, Xu, Xun, Liu, Longqi, Chen, Ao, Lai, Yiwei, and Esteban, Miguel A.

Published
2024
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9. Author Correction: Global survey shows planners use widely varying sea-level rise projections for coastal adaptation

Author

Hirschfeld, Daniella, Behar, David, Nicholls, Robert J., Cahill, Niamh, James, Thomas, Horton, Benjamin P., Portman, Michelle E., Bell, Rob, Campo, Matthew, Esteban, Miguel, Goble, Bronwyn, Rahman, Munsur, Addo, Kwasi Appeaning, Chundeli, Faiz Ahmed, Aunger, Monique, Babitsky, Orly, Beal, Anders, Boyle, Ray, Fang, Jiayi, Gohar, Amir, Hanson, Susan, Karamesines, Saul, Kim, M. J., Lohmann, Hilary, McInnes, Kathy, Mimura, Nobuo, Ramsay, Doug, Wenger, Landis, and Yokoki, Hiromune

Published
2023
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12. Global survey shows planners use widely varying sea-level rise projections for coastal adaptation

Author

Hirschfeld, Daniella, Behar, David, Nicholls, Robert J., Cahill, Niamh, James, Thomas, Horton, Benjamin P., Portman, Michelle E., Bell, Rob, Campo, Matthew, Esteban, Miguel, Goble, Bronwyn, Rahman, Munsur, Addo, Kwasi Appeaning, Chundeli, Faiz Ahmed, Aunger, Monique, Babitsky, Orly, Beal, Anders, Boyle, Ray, Fang, Jiayi, Gohar, Amir, Hanson, Susan, Karamesines, Saul, Kim, M. J., Lohmann, Hilary, McInnes, Kathy, Mimura, Nobuo, Ramsay, Doug, Wenger, Landis, and Yokoki, Hiromune

Published
2023
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14. Wastewater and Grey Water Footprint Assessment of the Olive Oil Production Process in Northwest Argentina

Author

Evelyn Vuksinic, Roberto Esteban Miguel, Maite M. Aldaya, and Corina Iris Rodriguez

Subjects
olive mill wastewater, water resource management, water footprint, pollution control, virtual water trade, Hydraulic engineering, TC1-978, Water supply for domestic and industrial purposes, TD201-500
Abstract

Argentina stands as the leading producer and exporter of olive products in the Americas, with the province of La Rioja as its main productive area. Since the 1990s, the olive grove cultivated area and related agro-industry in La Rioja have expanded. However, the resulting wastewater has generally been neglected. The water footprint (WF) provides information about the water volume consumed and polluted by a production process. Since the 1990s, agricultural and agro-industrial activities in La Rioja have experienced substantial growth. This study aims to analyze the generation, quality, and management of Oil Mill Wastewater (OMWW) using the grey WF of chloride and nitrate as an indicator and focusing on two olive mills (OM) in La Rioja. Additionally, it seeks to examine the relationship between the international trade of provincial olive oil and the estimated grey WF. For the diagnosis of OMWW generation, a description of the production process was made coupled with flow and physico-chemical characterization. The total grey WF was 8.69 and 45.5 L water/L olive oil for OM 1 and OM 2, respectively. Nitrate was identified as the critical pollutant. The grey virtual water export related to the export of olive oil was 5569 m3 for OM 1 and 28,000 m3 for OM 2. The provincial grey virtual water export related to olive oil was 161,955 m3 with major trade destinations including Spain, the United States, and Brazil. The article analyses for the first time the grey WF of olive oil industries and assess the related grey virtual water exports. This research represents a step forward in the knowledge of wastewater management in the olive oil sector and facilitates the search for solutions to minimize negative environmental impacts while promoting cleaner production.

Published
2024
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17. Live birth of chimeric monkey with high contribution from embryonic stem cells

Author

Cao, Jing, Li, Wenjuan, Li, Jie, Mazid, Md. Abdul, Li, Chunyang, Jiang, Yu, Jia, Wenqi, Wu, Liang, Liao, Zhaodi, Sun, Shiyu, Song, Weixiang, Fu, Jiqiang, Wang, Yan, Lu, Yong, Xu, Yuting, Nie, Yanhong, Bian, Xinyan, Gao, Changshan, Zhang, Xiaotong, Zhang, Liansheng, Shang, Shenshen, Li, Yunpan, Fu, Lixin, Liu, Hao, Lai, Junjian, Wang, Yang, Yuan, Yue, Jin, Xin, Li, Yan, Liu, Chuanyu, Lai, Yiwei, Shi, Xuyang, Maxwell, Patrick H., Xu, Xun, Liu, Longqi, Poo, Muming, Wang, Xiaolong, Sun, Qiang, Esteban, Miguel A., and Liu, Zhen

Published
2023
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19. Senescence atlas reveals an aged-like inflamed niche that blunts muscle regeneration

Author

Moiseeva, Victoria, Cisneros, Andrés, Sica, Valentina, Deryagin, Oleg, Lai, Yiwei, Jung, Sascha, Andrés, Eva, An, Juan, Segalés, Jessica, Ortet, Laura, Lukesova, Vera, Volpe, Giacomo, Benguria, Alberto, Dopazo, Ana, Aznar-Benitah, Salvador, Urano, Yasuteru, del Sol, Antonio, Esteban, Miguel A., Ohkawa, Yasuyuki, Serrano, Antonio L., Perdiguero, Eusebio, and Muñoz-Cánoves, Pura

Published
2023
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22. Rolling back human pluripotent stem cells to an eight-cell embryo-like stage

Author

Mazid, Md. Abdul, Ward, Carl, Luo, Zhiwei, Liu, Chuanyu, Li, Yunpan, Lai, Yiwei, Wu, Liang, Li, Jinxiu, Jia, Wenqi, Jiang, Yu, Liu, Hao, Fu, Lixin, Yang, Yueli, Ibañez, David P., Lai, Junjian, Wei, Xiaoyu, An, Juan, Guo, Pengcheng, Yuan, Yue, Deng, Qiuting, Wang, Yang, Liu, Ying, Gao, Fei, Wang, Junwen, Zaman, Shahriar, Qin, Baoming, Wu, Guangming, Maxwell, Patrick H., Xu, Xun, Liu, Longqi, Li, Wenjuan, and Esteban, Miguel A.

Published
2022
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23. Author Correction: Felodipine induces autophagy in mouse brains with pharmacokinetics amenable to repurposing.

Author

Siddiqi, Farah H, Menzies, Fiona M, Lopez, Ana, Stamatakou, Eleanna, Karabiyik, Cansu, Ureshino, Rodrigo, Ricketts, Thomas, Jimenez-Sanchez, Maria, Esteban, Miguel Angel, Lai, Liangxue, Tortorella, Micky D, Luo, Zhiwei, Liu, Hao, Metzakopian, Emmanouil, Fernandes, Hugo JR, Bassett, Andrew, Karran, Eric, Miller, Bruce L, Fleming, Angeleen, and Rubinsztein, David C

Subjects
MD Multidisciplinary
Abstract

An amendment to this paper has been published and can be accessed via a link at the top of the paper.

Published
2019

24. Felodipine induces autophagy in mouse brains with pharmacokinetics amenable to repurposing.

Author

Siddiqi, Farah H, Menzies, Fiona M, Lopez, Ana, Stamatakou, Eleanna, Karabiyik, Cansu, Ureshino, Rodrigo, Ricketts, Thomas, Jimenez-Sanchez, Maria, Esteban, Miguel Angel, Lai, Liangxue, Tortorella, Micky D, Luo, Zhiwei, Liu, Hao, Metzakopian, Emmanouil, Fernandes, Hugo JR, Bassett, Andrew, Karran, Eric, Miller, Bruce L, Fleming, Angeleen, and Rubinsztein, David C

Subjects
Cerebral Cortex, Neurons, Cell Line, Embryo, Nonmammalian, Animals, Mice, Inbred C57BL, Animals, Genetically Modified, Zebrafish, Swine, Swine, Miniature, Humans, Mice, Neurodegenerative Diseases, Disease Models, Animal, Felodipine, Neuroprotective Agents, Treatment Outcome, Mutation, Autophagy, Female, Male, alpha-Synuclein, Embryo, Mammalian, Induced Pluripotent Stem Cells, Drug Repositioning, Primary Cell Culture, Brain Disorders, Neurodegenerative, Neurosciences, Orphan Drug, Dementia, Acquired Cognitive Impairment, Rare Diseases, Aging, 5.1 Pharmaceuticals, 2.1 Biological and endogenous factors, Neurological, Embryo, Nonmammalian, Inbred C57BL, Genetically Modified, Miniature, Disease Models, Animal, Mammalian, MD Multidisciplinary
Abstract

Neurodegenerative diseases like Alzheimer's disease, Parkinson's disease and Huntington's disease manifest with the neuronal accumulation of toxic proteins. Since autophagy upregulation enhances the clearance of such proteins and ameliorates their toxicities in animal models, we and others have sought to re-position/re-profile existing compounds used in humans to identify those that may induce autophagy in the brain. A key challenge with this approach is to assess if any hits identified can induce neuronal autophagy at concentrations that would be seen in humans taking the drug for its conventional indication. Here we report that felodipine, an L-type calcium channel blocker and anti-hypertensive drug, induces autophagy and clears diverse aggregate-prone, neurodegenerative disease-associated proteins. Felodipine can clear mutant α-synuclein in mouse brains at plasma concentrations similar to those that would be seen in humans taking the drug. This is associated with neuroprotection in mice, suggesting the promise of this compound for use in neurodegeneration.

Published
2019

27. Cell transcriptomic atlas of the non-human primate Macaca fascicularis

Author

Han, Lei, Wei, Xiaoyu, Liu, Chuanyu, Volpe, Giacomo, Zhuang, Zhenkun, Zou, Xuanxuan, Wang, Zhifeng, Pan, Taotao, Yuan, Yue, Zhang, Xiao, Fan, Peng, Guo, Pengcheng, Lai, Yiwei, Lei, Ying, Liu, Xingyuan, Yu, Feng, Shangguan, Shuncheng, Lai, Guangyao, Deng, Qiuting, Liu, Ya, Wu, Liang, Shi, Quan, Yu, Hao, Huang, Yunting, Cheng, Mengnan, Xu, Jiangshan, Liu, Yang, Wang, Mingyue, Wang, Chunqing, Zhang, Yuanhang, Xie, Duo, Yang, Yunzhi, Yu, Yeya, Zheng, Huiwen, Wei, Yanrong, Huang, Fubaoqian, Lei, Junjie, Huang, Waidong, Zhu, Zhiyong, Lu, Haorong, Wang, Bo, Wei, Xiaofeng, Chen, Fengzhen, Yang, Tao, Du, Wensi, Chen, Jing, Xu, Shibo, An, Juan, Ward, Carl, Wang, Zongren, Pei, Zhong, Wong, Chi-Wai, Liu, Xiaolei, Zhang, Huafeng, Liu, Mingyuan, Qin, Baoming, Schambach, Axel, Isern, Joan, Feng, Liqiang, Liu, Yan, Guo, Xiangyu, Liu, Zhen, Sun, Qiang, Maxwell, Patrick H., Barker, Nick, Muñoz-Cánoves, Pura, Gu, Ying, Mulder, Jan, Uhlen, Mathias, Tan, Tao, Liu, Shiping, Yang, Huanming, Wang, Jian, Hou, Yong, Xu, Xun, Esteban, Miguel A., and Liu, Longqi

Published
2022
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28. Spatially resolved gene regulatory and disease-related vulnerability map of the adult Macaque cortex

Author

Lei, Ying, Cheng, Mengnan, Li, Zihao, Zhuang, Zhenkun, Wu, Liang, sun, Yunong, Han, Lei, Huang, Zhihao, Wang, Yuzhou, Wang, Zifei, Xu, Liqin, Yuan, Yue, Liu, Shang, Pan, Taotao, Xie, Jiarui, Liu, Chuanyu, Volpe, Giacomo, Ward, Carl, Lai, Yiwei, Xu, Jiangshan, Wang, Mingyue, Yu, Hao, Sun, Haixi, Yu, Qichao, Wu, Liang, Wang, Chunqing, Wong, Chi Wai, Liu, Wei, Xu, Liangzhi, Wei, Jingkuan, Chen, Dandan, Shang, Zhouchun, Li, Guibo, Ma, Kun, Cheng, Le, Ling, Fei, Tan, Tao, Chen, Kai, Tasic, Bosiljka, Dean, Michael, Ji, Weizhi, Yang, Huanming, Gu, Ying, Esteban, Miguel A., Li, Yuxiang, Chen, Ao, Niu, Yuyu, Zeng, Hongkui, Hou, Yong, Liu, Longqi, Liu, Shiping, and Xu, Xun

Published
2022
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32. Public support for flood adaptation policy in Tokyo lowland areas.

Author

Cao, Anh, Esteban, Miguel, and Onuki, Motoharu

Subjects
*PROTECTION motivation theory, *INFORMATION-seeking behavior, *STRUCTURAL equation modeling, *FLOOD risk, *PUBLIC support, *FLOOD warning systems
Abstract

Sea level rise induced flooding is projected to cause significant damage to the low-lying coastal areas of many countries around the planet. Many households located in vulnerable areas have already started to adapt to flooding, although some empirical studies indicate that informal adaptation is reaching its limit and that more formal countermeasures by governments will be necessary to cope with the increased flood risks. In such cases, public support for flood adaptation policy is crucial to ensure a successful and timely adaptation, as these strategies can directly affect coastal residents. However, there is limited understanding on the mechanisms and factors that determine public support for flood adaptation policy. Thus, this study proposes a new model – the Foundation of Adaptation Policy Support (FAPS) – which integrates the Protection Motivation Theory and the Risk Information Seeking and Processing models. FAPS was tested using structural equation modelling with latent variables and data that was collected from a household questionnaire survey conducted in the Tokyo lowland areas (n = 388), with the super levee representing a policy that could be applied to sea level rise adaptation. The proposed FAPS model showed a good fit with the collected data, indicating that the strongest predictors of policy support include the perceived effectiveness of the policy and the importance of the issue of flooding to individuals. Other important predictors of policy support include knowledge about flooding, the opinions of surrounding people (i.e. family and friends), and the systematic processing by respondents of information related to floods. The FAPS model sets the foundation for understanding the mechanisms of public support for adaptation policy and provides new insights into designing and planning such policies in practice. Key policy insights Perceived policy effectiveness and the importance of addressing floods are the strongest predictors of public support for adaptation policy. Increasing people's knowledge about flooding is essential to communicate the importance of adaptation policy. Investigating people's knowledge and the perceived importance of the issue of flooding prior to designing policies can predict public preferences for certain countermeasures. [ABSTRACT FROM AUTHOR]

Published
2024
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43. Author Correction: Senescence atlas reveals an aged-like inflamed niche that blunts muscle regeneration

Author

Moiseeva, Victoria, Cisneros, Andrés, Sica, Valentina, Deryagin, Oleg, Lai, Yiwei, Jung, Sascha, Andrés, Eva, An, Juan, Segalés, Jessica, Ortet, Laura, Lukesova, Vera, Volpe, Giacomo, Benguria, Alberto, Dopazo, Ana, Benitah, Salvador Aznar, Urano, Yasuteru, del Sol, Antonio, Esteban, Miguel A., Ohkawa, Yasuyuki, Serrano, Antonio L., Perdiguero, Eusebio, and Muñoz-Cánoves, Pura

Published
2023
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46. Tanta historia en tan poco espacio. Estudio transdisciplinar del altar fenicio de Caura (Coria del Río, Sevilla)

Author

Universidad de Sevilla. Departamento de Geografía Física y Análisis Geográfico Regional, Universidad de Sevilla. Departamento de Prehistoria y Arqueología, Junta de Andalucía, Ministerio de Economia, Industria y Competitividad (MINECO). España, Bernáldez-Sánchez, Eloísa, García-Viñas, Esteban, Gamero Esteban, Miguel, Borja Barrera, Francisco, Borja Barrera, César, Recio Espejo, José Manuel, Granados Trillo, Cristina, Royo García, María A., Ubera Jiménez, José Luis, Villate Aliaga, Enrique, Ocaña García de Veas, Aurora, Escacena Carrasco, José Luis, Universidad de Sevilla. Departamento de Geografía Física y Análisis Geográfico Regional, Universidad de Sevilla. Departamento de Prehistoria y Arqueología, Junta de Andalucía, Ministerio de Economia, Industria y Competitividad (MINECO). España, Bernáldez-Sánchez, Eloísa, García-Viñas, Esteban, Gamero Esteban, Miguel, Borja Barrera, Francisco, Borja Barrera, César, Recio Espejo, José Manuel, Granados Trillo, Cristina, Royo García, María A., Ubera Jiménez, José Luis, Villate Aliaga, Enrique, Ocaña García de Veas, Aurora, and Escacena Carrasco, José Luis

Abstract

Las excelentes condiciones de conservación del altar del siglo VII a.C., encontrado en 1997 en el santuario proto histórico de Caura (Cerro de San Juan, Coria del Río, Sevilla), aconsejaron su extracción en bloque para su exposición en el Museo Arqueológico de Sevilla. No obstante, previamente a su puesta en valor, desde el Instituto Andaluz del Patrimonio Histórico de la Junta de Andalucía se procedió a la restauración del ara. Para aliviar su peso se llevó a cabo un vaciado par cial de la pieza mediante un proceso de microexcavación de la misma. El material obtenido por este procedimiento fue so metido a análisis geológicos, arqueobotánicos y arqueozoológicos, con el objeto tanto de determinar el origen, la naturale za y la disposición de los materiales de construcción de la pieza ritual, como de interpretar su entorno natural, ayudando así a clarificar los planteamientos realizados inicialmente por arqueólogos e historiadores. Los resultados de los distintos análisis coinciden en el uso de sustratos limpios para la construcción del altar, corroborando la hipótesis histórica de par tida y proporcionando información paleoambiental., The excellent state of conservation of the altar from the 7th century BC, found in 1997 in the protohistoric sanctu ary of Caura (Cerro de San Juan, Coria del Río, Seville), advised its complete extraction for its exhibition in the Museo Arque ológico de Sevilla. However, prior to its enhancement, the Instituto Andaluz del Patrimonio Histórico of the Junta de Anda lucía carried out the restoration of this altar. To reduce its weight, a partial emptying of the piece was carried out through a micro-excavation process. The material obtained by this procedure was subjected to geological, archaeobotanical and arche ozoological analysis. The aim of all of them is determining the origin, nature, and disposition of the construction materials of the ritual piece and interpreting its natural environment. Thus, helping to clarify the approaches initially made by archae ologists and historians. The results of the different analyzes coincide in the use of clean substrates for the construction of the altar, corroborating the initial historical hypothesis and providing paleoenvironmental information.

Published
2024

47. Contribución del Sociograma al enfoque Nexo Agua, Energía y Alimentación. Avances en el estudio del Valle Antinaco – Los Colorados (La Rioja, Argentina)

Author

María Cecilia Gareis and Roberto Esteban Miguel

Subjects
metodologías participativas, diagnóstico, desarrollo territorial, Social Sciences, Social sciences (General), H1-99
Abstract

El objetivo de este trabajo es identificar los actores sociales que se relacionan desde el enfoque del Nexo Agua, Energía y Alimentación en el Valle Antinaco – Los Colorados (VALC) y, a partir de allí, proponer grupos objetivos sobre los que avanzar para articular territorialmente el enfoque. Los pasos metodológicos consistieron en la elaboración del sociograma de manera participativa, allí se identificaron los actores y sus relaciones, se efectuaron ajustes en gabinete y se validaron los resultados en mesas de intercambio. Se identificaron 81 actores, 255 vinculaciones y se propusieron cuatro grupos objetivo, conformados por conjuntos diversos de actores, a los que sería conveniente comunicar, invitar e involucrar a participar del enfoque en el VALC.

Published
2022
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50. Experimental investigation into the effects of strong winds on the transport of overtopping water mass over a vertical seawall.

Author

Inagaki, Naoto, Shibayama, Tomoya, Nakamura, Ryota, Ishibashi, Kunihiko, and Esteban, Miguel

Subjects
WATER masses, WIND waves, WATER waves, WIND pressure, WIND tunnels, SEA-walls
Abstract

Hydraulic experiments using a wave flume with a wind tunnel at a scale of 1/40 were carried out to investigate the effect of wind on wave overtopping of a vertical seawall. To ascertain the possible effects of wave breaking, incident waves with various wave steepness (0.0102 to 0.0371) and three kinds of wind forcing (0 m/s, 6.84 m/s, 10.04 m/s) were used. The authors found that winds significantly increased the overtopping rate in general, and that there is a clear relationship between the overtopping rate and the wave steepness. Velocity fields obtained from PIV analysis revealed that the onshore winds directly enhanced the transport of overtopping water mass. The influence of the wind on the wave hydrodynamic processes that indirectly have an effect on the overtopping rate (such as the formation of a partially standing wave, breaker location, and breaker type) is also discussed. The perspective of treating wave overtopping as a transport of water mass could provide a novel understanding of complex fluid behavior, which would help to formulate countermeasures against future disasters influenced by intensive wind forcing. [ABSTRACT FROM AUTHOR]

Published
2024
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