1. Neural Activity Elicited by a Cognitive Task can be Detected in Single-Trials with Simultaneous Intracerebral EEG-fMRI Recordings
- Author
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Jean-Philippe Lachaux, Mathilde Petton, Philippe Ryvlin, Sylvain Rheims, Carolina Ciumas, Romain Bouet, Sébastien Boulogne, David W. Carmichael, and Mani Saignavongs
- Subjects
Male ,Drug Resistant Epilepsy ,genetic structures ,Electroencephalography ,Multimodal Imaging ,Task (project management) ,Magnetic Resonance Imaging/methods ,Epilepsy ,0302 clinical medicine ,Cognition ,Oxygen/blood ,Gamma Rhythm ,Cognition/physiology ,Brain Mapping ,medicine.diagnostic_test ,05 social sciences ,Anticonvulsants/therapeutic use ,Brain ,General Medicine ,Magnetic Resonance Imaging ,Electrodes, Implanted ,Pattern Recognition, Visual ,Cerebrovascular Circulation ,Intracerebral EEG ,Anticonvulsants ,Female ,Epilepsies, Partial/diagnostic imaging ,Pattern Recognition, Visual/physiology ,Multimodal Imaging/methods ,Adult ,Gamma Rhythm/physiology ,Computer Networks and Communications ,Cerebrovascular Circulation/physiology ,behavioral disciplines and activities ,050105 experimental psychology ,Electrocorticography/methods ,03 medical and health sciences ,Neural activity ,Young Adult ,Brain Mapping/methods ,medicine ,Humans ,0501 psychology and cognitive sciences ,Drug Resistant Epilepsy/diagnostic imaging ,Neural correlates of consciousness ,business.industry ,medicine.disease ,Brain/diagnostic imaging ,Oxygen ,Reading ,Artificial intelligence ,Electrocorticography ,Epilepsies, Partial ,business ,Functional magnetic resonance imaging ,Neuroscience ,030217 neurology & neurosurgery - Abstract
Recent studies have shown that it is feasible to record simultaneously intracerebral EEG (icEEG) and functional magnetic resonance imaging (fMRI) in patients with epilepsy. While it has mainly been used to explore the hemodynamic changes associated with epileptic spikes, this approach could also provide new insight into human cognition. However, the first step is to ensure that cognitive EEG components, that have lower amplitudes than epileptic spikes, can be appropriately detected under fMRI. We compared the high frequency activities (HFA, 50–150[Formula: see text]Hz) elicited by a reading task in icEEG-only and subsequent icEEG-fMRI in the same patients ([Formula: see text]), implanted with depth electrodes. Comparable responses were obtained, with 71% of the recording sites that responded during the icEEG-only session also responding during the icEEG-fMRI session. For all the remaining sites, nearby clusters (distant of 7[Formula: see text]mm or less) also demonstrated significant HFA increase during the icEEG-fMRI session. Significant HFA increases were also observable at the single-trial level in icEEG-fMRI recordings. Our results show that low-amplitude icEEG signal components such as cognitive-induced HFAs can be reliably recorded with simultaneous fMRI. This paves the way for the use of icEEG-fMRI to address various fundamental and clinical issues, notably the identification of the neural correlates of the BOLD signal.
- Published
- 2017