42 results on '"Eddyani, Miriam"'
Search Results
2. Volatile organic compound detection of Buruli ulcer disease: Headspace analysis of Mycobacterium ulcerans and used gauzes of Buruli-compatible ulcers.
- Author
-
Chudy, Stan F. J., Phanzu, Delphin M., Kolk, Arend H. J., Sopoh, Ghislain E., Barogui, Yves T., Tzfadia, Oren, Eddyani, Miriam, Fissette, Krista, de Jong, Bouke C., and Brinkman, Paul
- Subjects
VOLATILE organic compounds ,AIR sampling ,UNIVARIATE analysis ,METHYL cyclohexane ,THERMAL analysis ,BURULI ulcer - Abstract
Diagnosing Buruli ulcer (BU) is complicated by limited access to the sensitive IS2404 qPCR. Experienced clinicians report a distinct odour of Buruli ulcers. We explored the potential of headspace analysis by thermal desorption-gas chromatography-mass spectrometry to detect volatile organic compounds (VOCs) from Mycobacterium ulcerans both in vitro and clinically. This study was conducted in two phases: a discovery and validation phase. During the discovery phase, VOCs that enable identification of M. ulcerans cultures were determined. During the validation phase, these VOCs were evaluated in clinical samples for which we used gauzes from patients with skin ulcerations in the Democratic Republic of Congo. Seven M. ulcerans headspace samples were compared with four from sterile growth medium and laboratory environmental air. The univariate analysis resulted in the selection of 24 retained VOC fragments and a perfect differentiation between cultures and controls. Sixteen of 24 fragments were identified, resulting in eleven unique compounds, mainly alkanes. Methylcyclohexane was the best performing compound. Based on these 24 fragments, headspace samples originating from gauzes of 50 open skin lesions (12 qPCR positive and 38 negative) were analysed and an AUC of 0.740 (95%-CI 0.583–0.897) was obtained. As this is an experimental study, future research has to confirm whether the identified compounds can serve as novel biomarkers. Author summary: In this study the odour of bacteria that cause Buruli ulcer was examined. First, the air of bacteria cultured in the lab was analysed and compared with controls. Next, air was sampled from gauzes worn by people in the Kongo Central province, the Democratic Republic of Congo. Their lesions were compatible with Buruli ulcer disease but only 12 out of 50 were infected with the Buruli bacterium. In the odour of the Buruli bacteria and in gauzes from people with Buruli ulcer, several chemicals were present more abundantly than in gauzes from people with wounds caused by other diseases. Future research has to determine whether these chemicals can become part of a new test for Buruli ulcer disease. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
3. Population Genomics and Molecular Epidemiology of Mycobacterium ulcerans
- Author
-
Vandelannoote, Koen, Eddyani, Miriam, Buultjens, Andrew, Stinear, Timothy P., Pluschke, Gerd, editor, and Röltgen, Katharina, editor
- Published
- 2019
- Full Text
- View/download PDF
4. Diagnostic Accuracy of Clinical and Microbiological Signs in Patients With Skin Lesions Resembling Buruli Ulcer in an Endemic Region
- Author
-
Eddyani, Miriam, Sopoh, Ghislain E., Ayelo, Gilbert, Brun, Luc V. C., Roux, Jean-Jacques, Barogui, Yves, Affolabi, Dissou, Faber, William R., Boelaert, Marleen, Van Rie, Annelies, Portaels, Françoise, and de Jong, Bouke C.
- Published
- 2018
5. PERSISTENCE OF BURULI ULCER IN HISTORICAL FOCI OF KONGO CENTRAL PROVINCE, DR CONGO
- Author
-
Phanzu, Delphin Mavinga, Elysée Kalundieko Luzolo, Nlemvo, Oscar Kiabanzawoko, Makuth, Nadine Mintsey Mi, Vandelannoote, Koen, Eddyani, Miriam, Suykerbuyk, Patrick, Portaels, Françoise, Jong, Bouke C. De, and Boelaert, Marleen
- Published
- 2020
- Full Text
- View/download PDF
6. PS-003: EVIDENCE-INFORMED POLICY MAKING: CHALLENGES AND OPPORTUNITIES
- Author
-
Makanga, Michael, Beattie, Pauline, Breugelmans, Gabrielle, Nyirenda, Thomas, Bockarie, Moses, Tanner, Marcel, Volmink, Jimmy, Hankins, Catherine, Walzl, Gerhard, Chegou, Novel, Malherbe, Stephanus, Hatherill, Mark, Scriba, Thomas J., Zak, Daniel E., Barry, Clifton E., Kaufmann, Stefan H.E., Noor, Abdisalan, Strub-Wourgaft, Nathalie, Phillips, Patrick, Munguambe, Khátia, Ravinetto, Raffaella, Tinto, Halidou, Diro, Ermias, Mahendrahata, Yodi, Okebe, Joseph, Rijal, Suman, Garcia, Coralith, Sundar, Shyam, Ndayisaba, Gilles, Sopheak, Thai, Ngoduc, Thang, Loen, Harry Van, Jacobs, Jan, D'Alessandro, Umberto, Boelaert, Marleen, Buvé, Anne, Kamalo, Patrick, Manda-Taylor, Lucinda, Rennie, Stuart, Mokgatla, Boitumelo, Bahati, Prince, Ijsselmuiden, Carel, Afolabi, Muhammed, Mcgrath, Nuala, Kampmann, Beate, Imoukhuede, Egeruan, Alexander, Neal, Larson, Heidi, Chandramohan, Daniel, Bojang, Kalifa, Kasaro, Margaret Phiri, Muluka, Brenda, Kaunda, Kaunda, Morse, Jill, Westfall, Andrew, Kapata, Nathan, Kruuner, Annika, Henostroza, German, Reid, Stewart, Alabi, Abraham, Foguim, Francis, Sankarganesh, Jeyaraj, Bruske, Ellen, Mfoumbi, Arnault, Mevyann, Chester, Adegnika, Ayola, Lell, Bertrand, Kranzer, Katharina, Kremsner, Peter, Grobusch, Martin, Sabiiti, Wilber, Ntinginya, Nyanda, Kuchaka, Davis, Azam, Khalide, Kampira, Elizabeth, Mtafya, Bariki, Bowness, Ruth, Bhatt, Nilesh, Davies, Gerry, Kibiki, Gibson, Gillespie, Stephen, Lejon, Veerle, Ilboudo, Hamidou, Mumba, Dieudonné, Camara, Mamady, Kaba, Dramane, Lumbala, Crispin, Fèvre, Eric, Jamonneau, Vincent, Bucheton, Bruno, Büscher, Philippe, Chisenga, Caroline, Sinkala, Edford, Chilengi, Roma, Chitundu, Hellen, Zyambo, Zude, Wandeler, Gilles, Vinikoor, Michael, Emilie, Dama, Camara, Oumou, Mathurin, Koffi, Guiguigbaza-Kossigan, Dayo, Philippe, Büscher, Regassa, Fikru, Hassane, Sakande, Bienvenu, Somda Martin, Fabrice, Courtin, Ouédraogo, Elie, Kouakou, Lingue, Owusu, Michael, Mensah, Eric, Enimil, Anthony, Mutocheluh, Mohamed, Ndongo, Francis Ateba, Tejiokem, Mathurin Cyrille, Texier, Gaetan, Penda, Calixte, Ndiang, Suzie, Ndongo, Jean-Audrey, Guemkam, Georgette, Sofeu, Casimir Ledoux, Afumbom, Kfutwa, Faye, Albert, Msellati, Philippe, Warszawski, Josiane, Vos, Alinda, Devillé, Walter, Barth, Roos, Klipstein-Grobusch, Kerstin, Tempelman, Hugo, Venter, François, Coutinho, Roel, Grobbee, Diederick, Ssemwanga, Deogratius, Lyagoba, Frederick, Magambo, Brian, Kapaata, Anne, Kirangwa, Joseph, Nannyonjo, Maria, Nassolo, Faridah, Nsubuga, Rebecca, Yebra, Gonzalo, Brown, Andrew, Kaleebu, Pontiano, Nylén, Hanna, Habtewold, Abiy, Makonnen, Eyasu, Yimer, Getnet, Burhenne, Jürgen, Diczfalusy, Ulf, Aklillu, Eleni, Steele, Duncan, Walker, Richard, Simuyandi, Michelo, Beres, Laura, Bosomprah, Samuel, Ansumana, Rashid, Taitt, C., Lamin, J.M., Jacobsen, K.H., Mulvaney, S.P., Leski, T., Bangura, U., Stenger, D., Vries, Sophie De, Zinsou, Frejus Jeannot, Honkpehedji, J, Dejon, Jean Claude, Loembe, Marguerite Massinga, Bache, Bache, Pakker, Nadine, Leeuwen, Remko Van, Hounkpatin, Aurore Bouyoukou, Yazdanbakhsh, Maria, Bethony, Jeffrey, Hotez, Peter, Diemert, David, Bache, Bache Emmanuel, Fernandes, José F., Mba, Régis M Obiang, Kabwende, Anita L., Grobusch, Martin P., Krishna, Sanjeev, Kremsner, Peter G., Todagbe, Agnandji Selidji, Nambozi, Michael, Kabuya, Jean-Bertin, Hachizovu, Sebastian, Mwakazanga, David, Kasongo, Webster, Buyze, Jozefien, Mulenga, Modest, Geertruyden, Jean-Pierre, Gitaka, Jesse, Chan, Chim, Kongere, James, Kagaya, Wataru, Kaneko, Akira, Kabore, Naomie, Barry, Nouhoun, Kabre, Zachari, Werme, Karidia, Fofana, Aminata, Compaore, Daniel, Nikiema, Frederic, Some, Fabrice, Djimde, Abdoulaye, Zongo, Issaka, Ouedraogo, Bosco, Kone, Aminatou, Sagara, Issaka, Björkman, Anders, Gil, Jose Pedro, Nchinda, Godwin, Bopda, Alain, Nji, Nadesh, Ambada, Georgia, Ngu, Loveline, Tchadji, Jules, Sake, Carol, Magagoum, Suzanne, Njambe, Ghislain D., Lisom, Abel, Park, Chae Gyu, Tait, Dereck, Sibusiso, Hlatjwako, Manda, Olga, Croucher, Kristin, Westhuizen, Anja Van Der, Mshanga, Isaac, Levin, Jonathan, Nanvubya, Annet, Kibengo, Freddie, Jaoko, Walter, Pala, Pietro, Perreau, Matthieu, Namuniina, Annemarie, Kitandwe, Paul, Tapia, Gonzalo, Serwanga, Jennifer, Yates, Nicole, Fast, Pat, Mayer, Bryan, Montefiori, David, Tomaras, Georgia, Robb, Merlin, Lee, Carter, Wagner, Ralf, Sanders, Edward, Kilembe, William, Kiwanuka, Noah, Gilmour, Jill, Kuipers, Hester, Vooij, Dani, Chinyenze, Kundai, Priddy, Frances, Ding, Song, Hanke, Tom, Pantaleo, Giuseppe, Ngasala, Billy, Jovel, Irina, Malmberg, Maja, Mmbando, Bruno, Premji, Zul, Mårtensson, Andreas, Mwaiswelo, Richard, Agbor, Lenshina, Apinjoh, Tobias, Mwanza, Sydney, Chileshe, Justin, Joshi, Sudhaunshu, Malunga, Phidelis, Manyando, Christine, Laufer, Miriam, Dara, Antoine, Niangaly, Amadou, Sinha, Indranil, Brodin, David, Fofana, Bakary, Dama, Souleymane, Dembele, Demba, Sidibe, Bakary, Diallo, Nouhoum, Thera, Mahamadou, Wright, Karin, Gil, Jose, Doumbo, Ogobara, Baraka, Vito, Nabasumba, Carolyn, Francis, Filbert, Lutumba, Pascal, Mavoko, Hypolite, Alifrangis, Michael, Geertruyden, Jean-Pierre Van, Sissoko, Sekou, Sangaré, Cheick, Toure, Sekou, Sanogo, Kassim, Diakite, Hamadoun, Toure, Siaka, Doumbia, Diagassan, Haidara, Kadiatou, Julé, Amélie, Ashurst, Hazel, Merson, Laura, Olliaro, Piero, Marsh, Vicki, Lang, Trudie, Guérin, Philippe, Awuondo, Kennedy, Njenga, Daniel, Nyakarungu, Elizabeth, Titus, Pauline, Sutamihardja, Awalludin, Lowe, Brett, Ogutu, Bernhards, Billingsley, Peter, Soulama, Issiaka, Kaboré, Moïse, Coulibaly, Aboubacar, Ouattara, Maurice, Sanon, Souleymane, Diarra, Amidou, Bougouma, Edith, Ouedraogo, Alphonse, Sombie, Benjamin, Ouedraogo, Amidou, Kargougou, Désiré, Ouattara, Daouda, Issa, Nebie, Tiono, Alfred, Sirima, Sodiomon, Chaponda, Mike, Dabira, Edgard, Dao, François, Dara, Nianwalou, Sidibe, Bouran, Coulibaly, Moctar, Tolo, Allaye, Maiga, Hamma, Ouologuem, Nouhoum, Niangaly, Hamidou, Botchway, Felix, Wilson, Nana, Dickinson-Copeland, Carmen M, Adjei, Andrew A., Wilson, Michael, Stiles, Jonathan K., Hamid, Muzamil Abdel, Awad-Elgeid, Mona, Nasr, Awad, Netongo, Palmer, Kamdem, Séverin, Velavan, Thirumalaisamy, Lasry, Estrella, Diarra, Modibo, Bamadio, Amadou, Traore, Aliou, Coumare, Samba, Soma, Bahonan, Dicko, Yeyia, Sangare, Boubou, Tembely, Aly, Traore, Djibril, Haidara, Aboubecrin, Dicko, Alassane, Diawara, Elisabeth, Beavogui, Abdoul, Camara, Daouda, Sylla, Malick, Yattara, Mohamed, Sow, Amadou, Camara, Gnèpou Camara, Diallo, Saliou, Mombo-Ngoma, Ghyslain, Remppis, Jonathan, Sievers, Moritz, Manego, Rella Zoleko, Endamne, Lilian, Hutchinson, David, Held, Jana, Supan, Christian, Salazar, Carmen L. Ospina, Bonkian, Léa Nadège, Nahum, Alain, Sié, Ali, Abdulla, Salim, Cantalloube, Cathy, Djeriou, Elhadj, Bouyou-Akotet, Marielle, Mordmüller, Benjamin, Siribie, Mohamadou, Sirima, Sodiomon B., Ouattara, San Maurice, Coulibaly, Sam, Kabore, Jean Moïse, Amidou, Diarra, Tekete, Mamadou, Burhenne, Juergen, Traore, Oumar, Haefeli, Walter, Borrmann, Steffen, Kaboré, Naomie, Kabré, Zachari, Nikèma, Fréderic, Compaoré, Daniel, Somé, Fabrice, Djimdé, Abdoulaye, Ouédraogo, Jean, Chalwe, Victor, Miller, John, Diakité, Hamadoun, Greco, Beatrice, Spangenberg, Thomas, Kourany-Lefoll, Elly, Oeuvray, Claude, Mulry, Jim, Tyagarajan, Kamala, Magsaam, Bettina, Barnes, Karen, Hodel, Eva Maria, Humphreys, Georgina, Pace, Cheryl, Banda, C.G, Denti, Paulo, Allen, Elizabeth, Lalloo, David, Mwapasa, Victor, Terlouw, Anja, Mwesigwa, Julia, Achan, Jane, Jawara, Musa, Ditanna, Gian, Worwui, Archibald, Affara, Muna, Koukouikila-Koussounda, Félix, Kombo, Michael, Vouvoungui, Christevy, Ntoumi, Francine, Etoka-Beka, Mandingha Kosso, Deibert, Julia, Poulain, Pierre, Kobawila, Simon, Gueye, Nerly Gampio, Koukouikila-Koussounda, Felix, Seda, Brian, Kwambai, Titus, Jangu, Phelix, Samuels, Aaron, ter Kuile, Feike, Kariuki, Simon, Barry, Aissata, Bousema, Teun, Okech, Brenda, Egwang, Thomas, Corran, Patrick, Riley, Eleanor, Ezennia, Ifeoma, Ekwunife, Obinna, Muleba, Mbanga, Stevenson, Jennifer, Mbata, Keith, Coetzee, Maureen, Norris, Douglas, Moneke-Anyanwoke, Ngozi, Momodou, Jasseh, Clarke, Ed, Scott, Susana, Tijani, Adelani, Djimde, Moussa, Vaillant, Michel, Samouda, Hanen, Mensah, Victorine, Roetynck, Sophie, Kanteh, Ebrima, Bowyer, Georgina, Ndaw, Amy, Oko, Francis, Bliss, Carly, Jagne, Ya Jankey, Cortese, Riccardo, Nicosia, Alfredo, Roberts, Rachel, D'Alessio, Flavia, Leroy, Odile, Faye, Babacar, Cisse, Badara, Gerry, Stephen, Viebig, Nicola, Lawrie, Alison, Ewer, Katie, Hill, Adrian, Nebie, Issa, Tiono, Alfred B, Sanou, Guillaume, Konate, Amadou T, Yaro, Baptiste J, Sodiomon, Sirima, Honkpehedji, Yabo, Agobe, Jean Claude Dejon, Zinsou, Frejus, Mengue, Juliana, Richie, Thomas, Hoffman, Stephen, Nouatin, Odilon, Ngoa, Ulysse Ateba, Edoa, Jean R, Homoet, Andreas, Engelhon, Julie Englhon, Massinga-Louembe, Marguerite, Esen, Meral, Theisen, Michael, Sim, Kim Lee, Luty, Adrian Jf, Moutairou, Kabirou, Dinko, Bismarck, King, Elizabeth, Targett, Geoffrey, Sutherland, Colin, Likhovole, Clement, Ouma, Collins, Vulule, John, Musau, Susan, Khayumbi, Jeremiah, Okumu, Albert, Murithi, Wilfred, Otu, Jacob, Gehre, Florian, Zingue, Dezemon, Kudzawu, Samuel, Forson, Audrey, Mane, Morto, Rabna, Paulo, Diarra, Bassirou, Kayede, Salako, Adebiyi, Emmanuel, Kehinde, Aderemi, Onyejepu, Nneka, Onubogu, Catherine, Idigbe, Emmanuel, Ba, Awa, Diallo, Aissatou, Mboup, Souleymane, Disse, Kodjo, Kadanga, Gerard, Dagnra, Yaotse, Baldeh, Ignatius, Corrah, Tumani, Jong, Bouke De, Antonio, Martin, Musanabaganwa, Clarisse, Musabyimana, Jean Pierre, Karita, Etienne, Diop, Blondin, Nambajimana, Abidan, Dushimiyimana, Valentine, Karame, Prosper, Russell, Jim, Ndoli, Jules, Hategekimana, Theobald, Sendegeya, Augustin, Condo, Jeannine, Binagwaho, Agnes, Okonko, Iheanyi, Okerentugba, Phillip, Opaleye, Oluyinka, Awujo, Ezinwanne, Frank-Peterside, Nnenna, Moyo, Sikhulile, Kotokwe, Kenanao, Mohammed, Terence, Boleo, Coretah, Mupfumi, Lucy, Chishala, Samuel, Gaseitsiwe, Simani, Tsalaile, Lesedi, Bussmann, Herman, Makhema, Joseph, Baum, Marianna, Marlink, Richard, Engelbretch, Susan, Essex, Max, Novitsky, Vladimir, Saka, Emmanuel, Kalipalire, Zex, Bhairavabhotla, Ravikiran, Midiani, Dalitso, Sherman, Judith, Mgode, Georgies, Cox, Christophe, Bwana, Dickens, Mtui, Leah, Magesa, Daniel, Kahwa, Amos, Mfinanga, Godfrey, Mulder, Christiaan, Borain, Nick, Petersen, Lizette, Plessis, Julianne Du, Theron, Grant, Holm-Hansen, Carol, Tekwu, Emmanuel Mouafo, Sidze, Larissa Kamgue, Assam, Jean Paul Assam, Eyangoh, Sarah, Niemann, Stefan, Beng, Veronique Penlap, Frank, Matthias, Atiadeve, Samuel, Hilmann, Doris, Awoniyi, Dolapo, Baumann, Ralf, Kriel, Belinda, Jacobs, Ruschca, Kidd, Martin, Loxton, Andre, Kaempfer, Susanne, Singh, Mahavir, Mwanza, Winnie, Milimo, Deborah, Moyo, Maureen, Kasese, Nkatya, Cheeba-Lengwe, Maina, Munkondya, Stembiso, Ayles, Helen, Haas, Petra De, Muyoyeta, Monde, Namuganga, Anna Ritah, Kizza, Harriet Mayanja, Mendy, Alieu, Tientcheu, Leopold, Ayorinde, Abigail, Coker, Edward, Egere, Uzochukwu, Coussens, Anna, Naude, Celeste, Chaplin, George, Noursadeghi, Mahdad, Martineau, Adrian, Jablonski, Nina, Wilkinson, Robert, Ouedraogo, Henri Gautier, Matteelli, Alberto, Regazzi, Mario, Tarnagda, Grissoum, Villani, Paola, Sulis, Giorgia, Diagbouga, Serge, Roggi, Alberto, Giorgetti, Francesco, Kouanda, Seni, Bidias, Amel, Ndjonka, Dieudonné, Olemba, Clémence, Souleymanou, Arabo, Mukonzo, Jackson, Kuteesa, Ronald, Ogwal-Okeng, Jasper, Gustafsson, Lars L., Owen, Joel, Bassi, Peter, Gashau, Wadzani, Olaf, Klungel, Dodoo, Alexander, Okonkwo, Prosper, Kanki, Phyllis, Maruapula, Dorcas, Seraise, Boitumelo, Einkauf, Kevin, Reilly, Amanda, Rowley, Christopher, Musonda, Rosemary, Framhein, Anna, Mpagama, Stella, Semvua, Hadija, Maboko, Leonard, Hoelscher, Michael, Heinrich, Norbert, Mulenga, Lloyd, Kaayunga, Callistus, Davies, Mary-Ann, Egger, Matthias, Musukuma, Kalo, Dambe, Rosalia, Usadi, Benjamin, Ngari, Moses, Thitiri, Johnstone, Mwalekwa, Laura, Fegan, Greg, Berkley, James, Nsagha, Dickson, Munamunungu, Virginia, Bolton, Carolyn, Siyunda, Alice, Shilimi, Jacinta, Bucciardini, Raffaella, Fragola, Vincenzo, Abegaz, Teshome, Lucattini, Stefano, Halifom, Atakilt, Tadesse, Eskedar, Berhe, Micheal, Pugliese, Katherina, Castro, Paola De, Terlizzi, Roberta, Fucili, Luca, Gregorio, Massimiliano Di, Mirra, Marco, Zegeye, Teame, Binelli, Andrea, Vella, Stefano, Abraham, Loko, Godefay, Hagos, Rakotoarivelo, Rivo, Raberahona, Mihaja, Randriamampionona, Njary, Andriamihaja, Rabezanahary, Rasamoelina, Tahinamandranto, Cornet, Muriel, Randria, Mamy Jean De Dieu, Benet, Thomas, Vanhems, Philippe, Andrianarivelo, Mala Rakoto, Chirwa, Uchizi, Michelo, Charles, Hamoonga, Raymond, Wandiga, Steve, Oduor, Patience, Agaya, Janet, Sharma, Aditya, Cavanaugh, Sean, Cain, Kevin, Mukisa, John, Mupere, Ezekiel, Worodria, William, Ngom, Justice Trésor, Koro, Francioli, Godwe, Celestin, Adande, Clemence, Ateugieu, Romaric, Onana, Tatiana, Ngono, Annie, Kamdem, Yannick, Ngo-Niobe, Sara, Etoa, François-Xavier, Kanengoni, Muchineripi, Ruzario, Sithembile, Ndebele, Paul, Shana, Melody, Tarumbiswa, Fadzai, Musesengwa, Rosemary, Gutsire, Rutendo, Fisher, Kevin, Thyagarajan, Bargavi, Akanbi, Olusola, Binuyo, Michael, Ssengooba, Willy, Respeito, Durval, Mambuque, Edson, Blanco, Silvia, Mandomando, Inacio, Cobelens, Frank, Garcia-Basteiro, Alberto, Tamene, Ayele, Topp, Stephanie, Mwamba, Chanda, Padian, Nancy, Sikazwe, Izukanji, Geng, Elvin, Holmes, Charles, Sikombe, Kombatende, Hantuba, Cardinal, Czaicki, Nancy, Simbeza, Sandra, Somwe, Paul, Umulisa, Michele, Ilo, Jennifer, Kestelyn, Evelyne, Uwineza, Mireille, Agaba, Stephen, Delvaux, Therese, Wijgert, Janneke, Gethi, Dickson, Odeny, Lazarus, Tamandjou, Cynthia, Kaindjee-Tjituka, Francina, Brandt, Laura, Cotton, Mark, Nel, Etienne, Preiser, Wolfgang, Andersson, Monique, Adepoju, Abiola, Magana, Musa, Etsetowaghan, Andrew, Chilikwazi, Mutinta, Sutcliffe, Catherine, Thuma, Philip, Sinywimaanzi, Kathy, Matakala, Hellen, Munachoonga, Passwell, Moss, William, Masenza, Issa Sabi, Geisenberger, Otto, Agrea, Peter, Rwegoshora, France, Mahiga, Hellen, Olomi, Willyhelmina, Kroidl, Arne, Kayode, Gbenga, Amoakoh-Coleman, Mary, Ansah, Evelyn, Uthman, Olalekan, Fokam, Joseph, Santoro, Maria-Mercedes, Musolo, Chrissie, Chimbiri, Isabel, Chikwenga, Gloria, Deula, Ruth, Massari, Riccardo, Lungu, Agness, Perno, Carlo-Federico, Ndzengue, Georgia, Loveline, Ngu, Lissom, Abel, Flaurent, Tchouangueu, Sosso, Samuel, Essomba, Claudine, Kpeli, Grace, Otchere, Isaac, Lamelas, Araceli, Buultjens, Andrew, Bulach, Dieter, Baines, Sarah, Seemann, Torsten, Giulieri, Stefano, Nakobu, Zuliehatu, Aboagye, Samuel, Owusu-Mireku, Evelyn, Danso, Emelia, Hauser, Julia, Hinic, Vladimira, Pluschke, Gerd, Stinear, Timothy, Yeboah-Manu, Dorothy, Elshayeb, Ayman, Siddig, Marmar El, Ahmed, Abdel Azim, Hussien, Adil El, Kabwe, Mwila, Tembo, John, Chilukutu, Lophina, Chilufya, Moses, Ngulube, Francis, Lukwesa, Chileshe, Enne, Virve, Wexner, Hannah, Mwananyanda, Lawrence, Hamer, Davidson, Sinyangwe, Sylvester, Ahmed, Yusuf, Klein, Nigel, Maeurer, Markus, Zumla, Ali, Bates, Matthew, Beyala, Landry, Etienne, Guenou, Anthony, Njimbia, Benjamin, Azike, Ateudjieu, Jerome, Chibwe, Bertha, Ojok, David, Tarr, Christine Attia, Perez, Guillermo Martinez, Omeonga, Senga, Kibungu, Fanta, Meyer, Ana, Lansana, Peter, Mayor, Alfredo, Onyango, Peter, Loggerenberg, François Van, Furtado, Tamzin, Boggs, Liam, Segrt, Alexis, Dochez, Carine, Burnett, Rosemary, Mphahlele, M. Jeffrey, Miiro, George, Mbidde, Edward, Peshu, Norbert, Kivaya, Esther, Ngowi, Bernard, Kavishe, Reginald, Maowia, Mukhtar, Sandstrom, Eric, Ayuo, Elizabeth, Mmbaga, Blandina, Leisegang, Cordelia, Thorpe, Marie, Batchilly, Elizabeth, N'Guessan, Jean-Pierre, Kanteh, Dembo, Søfteland, Solrun, Sebitloane, Motshedisi, Vwalika, Bellington, Taylor, Myra, Galappaththi-Arachchige, Hashini, Holmen, Sigve, Gundersen, Svein Gunnar, Ndhlovu, Patricia, Kjetland, Eyrun Floerecke, Kombe, Francis, Toohey, Jacintha, Pienaar, Elizabeth, Kredo, Tamara, Cham, Pa Modou, Abubakar, Ismaela, Dondeh, Bai Lamin, Vischer, Nerina, Pfeiffer, Constanze, Burri, Christian, Musukwa, Kalo, Zürcher, Samuel, Mwandu, Temwani, Bauer, Sophie, Adriko, Moses, Mwaura, Peter, Omolloh, Kevin, Jones, Clarer, Malecela, Mwelecele, Hamidu, Buhari Adamu, Jenner, Tettevi Edward, Asiedu, Larbi John, Osei-Atweneboana, Mike, Afeke, Innocent, Addo, Phyllis, Newman, Mercy, Durnez, Lies, Eddyani, Miriam, Ammisah, Nana, Abas, Mona, Quartey, Maxwell, Ablordey, Anthony, Akinwale, Olaoluwa, Adeneye, Adeniyi, Ezeugwu, Sylvanus, Olukosi, Yetunde, Adewale, Babatunde, Sulyman, Medinat, Mafe, Margaret, Okwuzu, Jane, Gyang, Pam, Nwafor, Timothy, Henry, Uzoma, Musa, Bilkisu, Ujah, Innocent, Agobé, Jean Claude Dejon, Grau-Pujol, Berta, Sacoor, Charfudin, Nhabomba, Augusto, Casellas, Aina, Quintó, Llorenç, Subirà, Carme, Giné, Ricard, Valentín, Antònia, Muñoz, Jose, Nikiema, Marguerite, Ky-Ba, Absatou, Comapore, Kiswendsida Abdou Muller, Traore, Alfred, Sangare, Lassana, Oluremi, Adeolu, Michel, Mandro, Camara, Yaya, Sanneh, Bakary, Cuamba, Inocencia, Gutiérrez, Jose, Lázaro, Carlota, Mejia, Rojelio, Adedeji, Abimbola, Folorunsho, Sola, Demehin, Pelumi, Akinsanya, Bamidele, Cowley, Giovanna, Silva, Eunice Teixeira Da, Nabicassa, Meno, Barros, Pedrozinho Duarte Pereira De, Blif, Milena Mbote, Bailey, Robin, Last, Anna, Mahendradhata, Yodi, Gotuzzo, Eduardo, Nys, Kateljine De, Casteels, Minnes, Nona, Sylvie Kwedi, Lumeka, Kabwende, Todagbe, Agnandji, Djima, Mariam Mama, Ukpong, Morenike, Sagay, Atiene, Khamofu, Hadiza, Torpey, Kwasi, Afiadigwe, Evaristus, Anenih, James, Ezechi, Oliver, Nweneka, Chidi, Idoko, John, Muhumuza, Simon, Katahoire, Anne, Nuwaha, Fred, Olsen, Annette, Okeyo, Seth, Omollo, Raymond, Kimutai, Robert, Ochieng, Michael, Egondi, Thaddaeus, Moonga, Clement, Chileshe, Chisele, Magwende, George, Anumudu, Chiaka, Onile, Olugbenga, Oladele, Victoria, Adebayo, Adewale, Awobode, Henrietta, Oyeyemi, Oyetunde, Odaibo, Alexander, Kabuye, Emily, Lutalo, Tom, Njua-Yafi, Clarisse, Nkuo-Akenji, Theresa, Anchang-Kimbi, Judith, Mugri, Regina, Chi, Hanesh, Tata, Rolland, Njumkeng, Charles, Dodoo, Daniel, Achidi, Eric, Fernandes, José, Bache, Emmanuel B., Matakala, Kalumbu, Searle, Kelly, Greenman, Michelle, and Rainwater-Lovett, Kaitlin
- Subjects
Abstracts of Poster Presentations ,Abstracts of Oral Presentations ,Author Index ,Abstracts of Presentations in Plenary Sessions ,Article ,Abstracts of the Eighth Edctp Forum, 6–9 November 2016 - Published
- 2017
7. On the origin of Mycobacterium ulcerans, the causative agent of Buruli ulcer
- Author
-
Doig Kenneth D, Holt Kathryn E, Fyfe Janet AM, Lavender Caroline J, Eddyani Miriam, Portaels Françoise, Yeboah-Manu Dorothy, Pluschke Gerd, Seemann Torsten, and Stinear Timothy P
- Subjects
Biotechnology ,TP248.13-248.65 ,Genetics ,QH426-470 - Abstract
Abstract Background Mycobacterium ulcerans is an unusual bacterial pathogen with elusive origins. While closely related to the aquatic dwelling M. marinum, M. ulcerans has evolved the ability to produce the immunosuppressive polyketide toxin mycolactone and cause the neglected tropical disease Buruli ulcer. Other mycolactone-producing mycobacteria (MPM) have been identified in fish and frogs and given distinct species designations (M. pseudoshottsii, M. shinshuense, M. liflandii and M. marinum), however the evolution of M. ulcerans and its relationship to other MPM has not been defined. Here we report the comparative analysis of whole genome sequences from 30 MPM and five M. marinum. Results A high-resolution phylogeny based on genome-wide single nucleotide polymorphisms (SNPs) showed that M. ulcerans and all other MPM represent a single clonal group that evolved from a common M. marinum progenitor. The emergence of the MPM was driven by the acquisition of the pMUM plasmid encoding genes for the biosynthesis of mycolactones. This change was accompanied by the loss of at least 185 genes, with a significant overrepresentation of genes associated with cell wall functions. Cell wall associated genes also showed evidence of substantial adaptive selection, suggesting cell wall remodeling has been critical for the survival of MPM. Fine-grain analysis of the MPM complex revealed at least three distinct lineages, one of which comprised a highly clonal group, responsible for Buruli ulcer in Africa and Australia. This indicates relatively recent transfer of M. ulcerans between these continents, which represent the vast majority of the global Buruli ulcer burden. Our data provide SNPs and gene sequences that can differentiate M. ulcerans lineages, suitable for use in the diagnosis and surveillance of Buruli ulcer. Conclusions M. ulcerans and all mycolactone-producing mycobacteria are specialized variants of a common Mycobacterium marinum progenitor that have adapted to live in restricted environments. Examination of genes lost or retained and now under selective pressure suggests these environments might be aerobic, and extracellular, where slow growth, production of an immune suppressor, cell wall remodeling, loss or modification of cell wall antigens, and biofilm-forming ability provide a survival advantage. These insights will guide our efforts to find the elusive reservoir(s) of M. ulcerans and to understand transmission of Buruli ulcer.
- Published
- 2012
- Full Text
- View/download PDF
8. Subcutaneous Granulomatous Inflammation due to Basidiobolomycosis: Case Reports of 3 Patients in Buruli Ulcer Endemic Areas in Benin
- Author
-
Brun, Luc V. C., Roux, Jean Jacques, Sopoh, Ghislain E., Aguiar, Julia, Eddyani, Miriam, Meyers, Wayne M., Stubbe, Dirk, Akele Akpo, Marie T., Portaels, Françoise, and de Jong, Bouke C.
- Subjects
Article Subject - Abstract
Background. Basidiobolomycosis is a rare subcutaneous mycosis, which can be mistaken for several other diseases, such as soft tissue tumors, lymphoma, or Buruli ulcer in the preulcerative stage. Microbiological confirmation by PCR for Basidiobolus ranarum and culture yield the most specific diagnosis, yet they are not widely available in endemic areas and with varying sensitivity. A combination of histopathological findings, namely, granulomatous inflammation with giant cells, septate hyphal fragments, and the Splendore-Hoeppli phenomenon, can confirm basidiobolomycosis in patients presenting with painless, hard induration of soft tissue. Case Presentations. We report on three patients misdiagnosed as suffering from Buruli ulcer, who did not respond to Buruli treatment. Histopathological review of the tissue sections from these patients suggests basidiobolomycosis. All patients had been lost to follow-up, and none received antifungal therapy. On visiting the patients at their homes, two were reported to have died of unknown causes. The third patient was found alive and well and had experienced local spontaneous healing. Conclusion. Basidiobolomycosis is a rare subcutaneous fungal disease mimicking preulcerative Buruli ulcer. We stress the importance of the early recognition by clinicians and pathologists of this treatable disease, so patients can timely receive antifungal therapy.
- Published
- 2018
- Full Text
- View/download PDF
9. Mycobacterium ulcerans Population Genomics To Inform on the Spread of Buruli Ulcer across Central Africa
- Author
-
Vandelannoote, Koen, primary, Phanzu, Delphin Mavinga, additional, Kibadi, Kapay, additional, Eddyani, Miriam, additional, Meehan, Conor J., additional, Jordaens, Kurt, additional, Leirs, Herwig, additional, Portaels, Françoise, additional, Stinear, Timothy P., additional, Harris, Simon R., additional, and de Jong, Bouke C., additional
- Published
- 2019
- Full Text
- View/download PDF
10. Multiple introductions and recent spread of the emerging human pathogen Mycobacterium ulcerans across Africa Running title: Population genomics of M. ulcerans in Africa
- Author
-
Vandelannoote, Koen, Meehan, Conor, Eddyani, Miriam, Affolabi, Dissou, Phanzu, Delphin, Eyangoh, Sara, Jordaens, Kurt, Portaels, Françoise, Mangas, Kirstie, Seemann, Torsten, Marsollier, Laurent, Marion, Estelle, Chauty, Annick, Landier, Jordi, Fontanet, Arnaud, Leirs, Herwig, Stinear, Timothy, de Jong, Bouke, Bernardo, Elizabeth, Evolutionary Ecology Group [Antwerp, Belgium], University of Antwerp (UA), Department of Biomedical Sciences [Antwerp], Institute of Tropical Medicine [Antwerp] (ITM), Laboratoire de Référence des Mycobactéries [Cotonou, Benin], Hôpital Centre LAZARET [Cotonou, Bénin], Projet Ulcère de Buruli [Kimpese, RD Congo], Institut Médical Evangélique [Kimpese, RD Congo], Centre Pasteur du Cameroun, Réseau International des Instituts Pasteur (RIIP), Invertebrates section, Royal Museum for Central Africa [Tervuren] (RMCA), Department of Microbiology and Immunology, University of Melbourne, Victorian Life Sciences Computation Initiative, Centre de Recherche en Cancérologie Nantes-Angers (CRCNA), Centre Hospitalier Universitaire d'Angers (CHU Angers), PRES Université Nantes Angers Le Mans (UNAM)-PRES Université Nantes Angers Le Mans (UNAM)-Hôtel-Dieu de Nantes-Institut National de la Santé et de la Recherche Médicale (INSERM)-Hôpital Laennec-Centre National de la Recherche Scientifique (CNRS)-Faculté de Médecine d'Angers-Centre hospitalier universitaire de Nantes (CHU Nantes), CDTUB de Pobè, Service de Mycobactériologie [Yaoundé, Cameroun], Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP), Epidémiologie des Maladies Emergentes - Emerging Diseases Epidemiology, Pasteur-Cnam Risques infectieux et émergents (PACRI), Institut Pasteur [Paris] (IP)-Conservatoire National des Arts et Métiers [CNAM] (CNAM), HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-Institut Pasteur [Paris] (IP)-Conservatoire National des Arts et Métiers [CNAM] (CNAM), HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM), and KV was supported by a PhD-grant of the Flemish Interuniversity Council - University Development Cooperation (Belgium). BdJ & CM were supported by the European Research Council-INTERRUPTB starting grant (nr.311725). TPS was supported by a fellowship from the National Health and Medical Research Council of Australia (1105525). Funding for this work was provided by the Department of Economy, Science and Innovation of the Flemish Government, the Stop Buruli Consortium supported by the UBS Optimus Foundation, and the Fund for Scientific Research Flanders (Belgium) (FWO grant n° G.0321.07N). The computational resources used in this work were provided by the HPC core facility CalcUA and VSC (Flemish Supercomputer Center), funded by the University of Antwerp, the Hercules Foundation and the Flemish Government - department EWI. Aspects of the research in Cameroon and Benin were funded by the Raoul Follereau Fondation France.
- Subjects
Phylogeography ,Bacterial pathogen transmission ,[SDV.CAN] Life Sciences [q-bio]/Cancer ,Microbial population genomics ,Molecular evolution ,[SDV.CAN]Life Sciences [q-bio]/Cancer - Abstract
International audience; Buruli ulcer (BU) is an insidious neglected tropical disease. Cases are reported around the world but the rural regions of West and Central Africa are most affected. How BU is transmitted and spreads has remained a mystery, even though the causative agent, Mycobacterium ulcerans, has been known for more than 70 years. Here, using the tools of population genomics, wereconstruct the evolutionary history of M. ulcerans by comparing 165 isolates spanning 48 years and representing 11 endemic countries across Africa. The genetic diversity of African M. ulcerans was found to be restricted due to the bacterium’s slow substitution rate coupled with its relatively recent origin. We identified two specific M. ulcerans lineages within the African continent, and inferred that M. ulcerans lineage Mu_A1 existed in Africa for several hundreds of years, unlike lineage Mu_A2, which was introduced much more recently, approximately during the 19th century. Additionally, we observed that specific M. ulcerans epidemic Mu_A1 clones were introduced during the same time period in the three hydrological basins that were well covered in our panel. The estimated time span of the introduction events coincides with the Neoimperialism period, during which time the European colonial powers divided the African continent among themselves. Using this temporal association, and in the absence of a known BU reservoir or –vector on the continent, we postulate that the so-called “Scramble for Africa” played a significant role in the spread of the disease across the continent.
- Published
- 2017
11. Improving clinical and epidemiological predictors of Buruli ulcer
- Author
-
Ayelo, Gilbert Adjimon, primary, Sopoh, Ghislain Emmanuel, additional, Houezo, Jean-Gabin, additional, Fiodessihoue, René, additional, Affolabi, Dissou, additional, Dossou, Ange Dodji, additional, Barogui, Yves Thierry, additional, Wadagni, Akpeedje Anita Carolle, additional, Agossadou, Didier Codjo, additional, Hasker, Epco, additional, Portaels, Françoise, additional, de Jong, Bouke C., additional, and Eddyani, Miriam, additional
- Published
- 2018
- Full Text
- View/download PDF
12. Comparative Genomics Shows That Mycobacterium ulcerans Migration and Expansion Preceded the Rise of Buruli Ulcer in Southeastern Australia
- Author
-
Buultjens, Andrew H., primary, Vandelannoote, Koen, additional, Meehan, Conor J., additional, Eddyani, Miriam, additional, de Jong, Bouke C., additional, Fyfe, Janet A. M., additional, Globan, Maria, additional, Tobias, Nicholas J., additional, Porter, Jessica L., additional, Tomita, Takehiro, additional, Tay, Ee Laine, additional, Seemann, Torsten, additional, Howden, Benjamin P., additional, Johnson, Paul D. R., additional, and Stinear, Timothy P., additional
- Published
- 2018
- Full Text
- View/download PDF
13. Additional file 1: of Buruli ulcer in Nigeria: results of a pilot case study in three rural districts
- Author
-
Ukwaja, Kingsley, Meka, Anthony, Chukwuka, Alphonsus, Asiedu, Kingsley, Huber, Kristina, Eddyani, Miriam, Chukwu, Joseph, Anyim, Moses, Nwafor, Charles, Oshi, Daniel, Madichie, Nelson, Ngozi Ekeke, Njoku, Martin, and Kentigern Ntana
- Abstract
Multilingual abstracts in the six official working languages of the United Nations. (PDF 329Â kb)
- Published
- 2016
- Full Text
- View/download PDF
14. Occurrence of free-living amoebae in communities of low and high endemicity for Buruli ulcer in southern Benin
- Author
-
Eddyani, Miriam, De Jonckheere, Johan F., Durnez, Lies, Suykerbuyk, Patrick, Leirs, Herwig, and Portaels, Francoise
- Subjects
Amoeba -- Health aspects ,Amoeba -- Environmental aspects ,Buruli ulcer -- Distribution ,Buruli ulcer -- Research ,Water pollution -- Benin ,Water pollution -- Health aspects ,Water pollution -- Control ,Company distribution practices ,Biological sciences - Abstract
A study is conducted to determine the nature and distribution of free-living amoebae in areas of Benin with low and high endemicities for Buruli ulcer (BU). The differences observed in socio-economic status between the areas and high and of low BU endemicity fail to explain the actual mechanism linking BU endemicity and the occurrence of free-living amoebae.
- Published
- 2008
15. First detection of mycobacteria in African rodents and insectivores, using stratified pool screening
- Author
-
Durnez, Lies, Eddyani, Miriam, Mgode, Georgies F., Katakweba, Abdul, Katholi, Charles R., Machang'u, Robert R., Kazwala, Rudovik R., Portaels, Francoise, and Leirs, Herwig
- Subjects
Mycobacteria -- Genetic aspects ,Mycobacteria -- Environmental aspects ,Mycobacterium -- Genetic aspects ,Mycobacterium -- Environmental aspects ,Polymerase chain reaction -- Usage ,Rodents -- Environmental aspects ,Rodents -- Genetic aspects ,Biological sciences - Abstract
The prevalence of mycobacteria in rodents and insectivores are studied in Morogoro, Tanzania, by using direct smear examination (DSE) after acid-fast staining technique. The findings have shown that potentially pathogenic mycobacteria have posed a risk for other animals and humans, especially HIV/AIDS patients, having a weakened immune system.
- Published
- 2008
16. Bacterial diversity in Buruli ulcer skin lesions: Challenges in the clinical microbiome analysis of a skin disease
- Author
-
Van Leuvenhaege, Chloé, primary, Vandelannoote, Koen, additional, Affolabi, Dissou, additional, Portaels, Françoise, additional, Sopoh, Ghislain, additional, de Jong, Bouke C., additional, Eddyani, Miriam, additional, and Meehan, Conor J., additional
- Published
- 2017
- Full Text
- View/download PDF
17. CULTIVATION OF TWO IS2404 POSITIVEMYCOBACTERIUM SPP.FROM THE ENVIRONMENT OF ASANTE AKIM DISTRICT OF GHANA
- Author
-
Afeke, Innocent, primary, Addo, Phyllis, additional, Newman, Mercy, additional, Durnez, Lies, additional, Eddyani, Miriam, additional, Ammisah, Nana, additional, Abas, Mona, additional, Quartey, Maxwell, additional, and Ablordey, Anthony, additional
- Published
- 2017
- Full Text
- View/download PDF
18. Multiple introductions and recent spread of the emerging human pathogen Mycobacterium ulcerans across Africa
- Author
-
Vandelannoote, Koen, primary, Meehan, Conor J., additional, Eddyani, Miriam, additional, Affolabi, Dissou, additional, Phanzu, Delphin Mavinga, additional, Eyangoh, Sara, additional, Jordaens, Kurt, additional, Portaels, Françoise, additional, Mangas, Kirstie, additional, Seemann, Torsten, additional, Marsollier, Laurent, additional, Marion, Estelle, additional, Chauty, Annick, additional, Landier, Jordi, additional, Fontanet, Arnaud, additional, Leirs, Herwig, additional, Stinear, Timothy P., additional, and de Jong, Bouke C., additional
- Published
- 2017
- Full Text
- View/download PDF
19. Potential role of fish in transmission of Mycobacterium ulcerans disease (Buruli ulcer): an environmental study
- Author
-
Eddyani, Miriam, Ofori-Adjei, David, Tuegels, Guy, De Weirdt, David, Boakye, Daniel, Meyers, Wayne M, and Portaels, Francoise
- Subjects
Fishes -- Genetic aspects ,Mycobacteria -- Genetic aspects ,Mycobacterium -- Genetic aspects ,Microbiological research ,Biological sciences - Abstract
The potential role that fish may play in the transmission of Mycobacterium ulcerans disease (Buruli ulcer) is investigated. The analysis supports that hypothesis that fish may be passive reservoirs of M. ulcerans but are not usually responsible for direct transmission.
- Published
- 2004
20. Buruli ulcer in Nigeria: results of a pilot case study in three rural districts
- Author
-
Ukwaja, Kingsley N., primary, Meka, Anthony O., additional, Chukwuka, Alphonsus, additional, Asiedu, Kingsley B., additional, Huber, Kristina L., additional, Eddyani, Miriam, additional, Chukwu, Joseph N., additional, Anyim, Moses C., additional, Nwafor, Charles C., additional, Oshi, Daniel C., additional, Madichie, Nelson O., additional, Ekeke, Ngozi, additional, Njoku, Martin, additional, and Ntana, Kentigern, additional
- Published
- 2016
- Full Text
- View/download PDF
21. A Genomic Approach to Resolving Relapse versus Reinfection among Four Cases of Buruli Ulcer
- Author
-
Eddyani, Miriam, primary, Vandelannoote, Koen, additional, Meehan, Conor J., additional, Bhuju, Sabin, additional, Porter, Jessica L., additional, Aguiar, Julia, additional, Seemann, Torsten, additional, Jarek, Michael, additional, Singh, Mahavir, additional, Portaels, Françoise, additional, Stinear, Timothy P., additional, and de Jong, Bouke C., additional
- Published
- 2015
- Full Text
- View/download PDF
22. Correction: Whole Genome Comparisons Suggest Random Distribution of Mycobacterium ulcerans Genotypes in a Buruli Ulcer Endemic Region of Ghana
- Author
-
Ablordey, Anthony S., primary, Vandelannoote, Koen, additional, Frimpong, Isaac A., additional, Ahortor, Evans K., additional, Amissah, Nana Ama, additional, Eddyani, Miriam, additional, Durnez, Lies, additional, Portaels, Françoise, additional, de Jong, Bouke C., additional, Leirs, Herwig, additional, Porter, Jessica L., additional, Mangas, Kirstie M., additional, Lam, Margaret M. C., additional, Buultjens, Andrew, additional, Seemann, Torsten, additional, Tobias, Nicholas J., additional, and Stinear, Timothy P., additional
- Published
- 2015
- Full Text
- View/download PDF
23. Whole Genome Comparisons Suggest Random Distribution of Mycobacterium ulcerans Genotypes in a Buruli Ulcer Endemic Region of Ghana
- Author
-
Ablordey, Anthony S., primary, Vandelannoote, Koen, additional, Frimpong, Isaac A., additional, Ahortor, Evans K., additional, Amissah, Nana Ama, additional, Eddyani, Miriam, additional, Durnez, Lies, additional, Portaels, Françoise, additional, de Jong, Bouke C., additional, Leirs, Herwig, additional, Porter, Jessica L., additional, Mangas, Kirstie M., additional, Lam, Margaret M. C., additional, Buultjens, Andrew, additional, Seemann, Torsten, additional, Tobias, Nicholas J., additional, and Stinear, Timothy P., additional
- Published
- 2015
- Full Text
- View/download PDF
24. Investigating the Role of Free-living Amoebae as a Reservoir for Mycobacterium ulcerans
- Author
-
Amissah, Nana Ama, primary, Gryseels, Sophie, additional, Tobias, Nicholas J., additional, Ravadgar, Bahram, additional, Suzuki, Mitsuko, additional, Vandelannoote, Koen, additional, Durnez, Lies, additional, Leirs, Herwig, additional, Stinear, Timothy P., additional, Portaels, Françoise, additional, Ablordey, Anthony, additional, and Eddyani, Miriam, additional
- Published
- 2014
- Full Text
- View/download PDF
25. Multicenter External Quality Assessment Program for PCR Detection of Mycobacterium ulcerans in Clinical and Environmental Specimens
- Author
-
Eddyani, Miriam, primary, Lavender, Caroline, additional, de Rijk, Willem Bram, additional, Bomans, Pieter, additional, Fyfe, Janet, additional, de Jong, Bouke, additional, and Portaels, Françoise, additional
- Published
- 2014
- Full Text
- View/download PDF
26. Insertion Sequence Element Single Nucleotide Polymorphism Typing Provides Insights into the Population Structure and Evolution of Mycobacterium ulcerans across Africa
- Author
-
Vandelannoote, Koen, primary, Jordaens, Kurt, additional, Bomans, Pieter, additional, Leirs, Herwig, additional, Durnez, Lies, additional, Affolabi, Dissou, additional, Sopoh, Ghislain, additional, Aguiar, Julia, additional, Phanzu, Delphin Mavinga, additional, Kibadi, Kapay, additional, Eyangoh, Sara, additional, Manou, Louis Bayonne, additional, Phillips, Richard Odame, additional, Adjei, Ohene, additional, Ablordey, Anthony, additional, Rigouts, Leen, additional, Portaels, Françoise, additional, Eddyani, Miriam, additional, and de Jong, Bouke C., additional
- Published
- 2014
- Full Text
- View/download PDF
27. Knowledge of morphology is still required when identifying new amoeba isolates by molecular techniques.
- Author
-
UCL - SSS/DDUV - Institut de Duve, De Jonckheere, Johan, Gryseels, Sophie, Eddyani, Miriam, UCL - SSS/DDUV - Institut de Duve, De Jonckheere, Johan, Gryseels, Sophie, and Eddyani, Miriam
- Abstract
We have isolated several free-living amoeba strains from the environment in Ghana, which have internal transcribed spacers, including the 5.8S rDNA, sequences similar to sequences attributed to Vahlkampfiidae (Heterolobosea) in databases. However, morphological examination shows that the isolates belong to the Hartmannellidae (Amoebozoa). We provide evidence that the sequences in the databases are wrongly classified as belonging to a genus or species of the Vahlkampfiidae, but rather belong to strains of the genus Hartmannella.
- Published
- 2012
28. Amoebae as potential environmental hosts for Mycobacterium ulcerans and other mycobacteria, but doubtful actors in Buruli ulcer epidemiology.
- Author
-
UCL - SSS/DDUV - Institut de Duve, Gryseels, Sophie, Amissah, Diana, Durnez, Lies, Vandelannoote, Koen, Leirs, Herwig, De Jonckheere, Johan, Silva, Manuel T, Portaels, Françoise, Ablordey, Anthony, Eddyani, Miriam, UCL - SSS/DDUV - Institut de Duve, Gryseels, Sophie, Amissah, Diana, Durnez, Lies, Vandelannoote, Koen, Leirs, Herwig, De Jonckheere, Johan, Silva, Manuel T, Portaels, Françoise, Ablordey, Anthony, and Eddyani, Miriam
- Abstract
This is the first report of experimental infection of amoebae with M. ulcerans and of the detection of the marker IS2404 in amoeba cultures isolated from the environment. We conclude that amoeba are potential natural hosts for M. ulcerans, yet remain sceptical about their implication in the transmission of M. ulcerans to humans and their importance in the epidemiology of Buruli ulcer.
- Published
- 2012
29. Amoebae as Potential Environmental Hosts for Mycobacterium ulcerans and Other Mycobacteria, but Doubtful Actors in Buruli Ulcer Epidemiology
- Author
-
Gryseels, Sophie, primary, Amissah, Diana, additional, Durnez, Lies, additional, Vandelannoote, Koen, additional, Leirs, Herwig, additional, De Jonckheere, Johan, additional, Silva, Manuel T., additional, Portaels, Françoise, additional, Ablordey, Anthony, additional, and Eddyani, Miriam, additional
- Published
- 2012
- Full Text
- View/download PDF
30. Knowledge of morphology is still required when identifying new amoeba isolates by molecular techniques
- Author
-
De Jonckheere, Johan F., primary, Gryseels, Sophie, additional, and Eddyani, Miriam, additional
- Published
- 2012
- Full Text
- View/download PDF
31. Effects of Decontamination, DNA Extraction, and Amplification Procedures on the Molecular Diagnosis of Mycobacterium ulcerans Disease (Buruli Ulcer)
- Author
-
Affolabi, Dissou, primary, Sanoussi, N′Dira, additional, Vandelannoote, Koen, additional, Odoun, Mathieu, additional, Faïhun, Frank, additional, Sopoh, Ghislain, additional, Anagonou, Séverin, additional, Portaels, Françoise, additional, and Eddyani, Miriam, additional
- Published
- 2012
- Full Text
- View/download PDF
32. Application of real-time PCR in Ghana, a Buruli ulcer-endemic country, confirms the presence ofMycobacterium ulceransin the environment
- Author
-
Vandelannoote, Koen, primary, Durnez, Lies, additional, Amissah, Diana, additional, Gryseels, Sophie, additional, Dodoo, Alfred, additional, Yeboah, Shirley, additional, Addo, Phyllis, additional, Eddyani, Miriam, additional, Leirs, Herwig, additional, Ablordey, Anthony, additional, and Portaels, Françoise, additional
- Published
- 2010
- Full Text
- View/download PDF
33. Fine-Needle Aspiration, an Efficient Sampling Technique for Bacteriological Diagnosis of Nonulcerative Buruli Ulcer
- Author
-
Eddyani, Miriam, primary, Fraga, Alexandra G., additional, Schmitt, Fernando, additional, Uwizeye, Cécile, additional, Fissette, Krista, additional, Johnson, Christian, additional, Aguiar, Julia, additional, Sopoh, Ghislain, additional, Barogui, Yves, additional, Meyers, Wayne M., additional, Pedrosa, Jorge, additional, and Portaels, Françoise, additional
- Published
- 2009
- Full Text
- View/download PDF
34. Primary Culture of Mycobacterium ulcerans from Human Tissue Specimens after Storage in Semisolid Transport Medium
- Author
-
Eddyani, Miriam, primary, Debacker, Martine, additional, Martin, Anandi, additional, Aguiar, Julia, additional, Johnson, Christian R., additional, Uwizeye, Cécile, additional, Fissette, Krista, additional, and Portaels, Françoise, additional
- Published
- 2008
- Full Text
- View/download PDF
35. Potential Role for Fish in Transmission of Mycobacterium ulcerans Disease (Buruli Ulcer): an Environmental Study
- Author
-
Eddyani, Miriam, primary, Ofori-Adjei, David, additional, Teugels, Guy, additional, De Weirdt, David, additional, Boakye, Daniel, additional, Meyers, Wayne M., additional, and Portaels, Françoise, additional
- Published
- 2004
- Full Text
- View/download PDF
36. Multicenter External Quality Assessment Program for PCR Detection of Mycobacterium ulcerans in Clinical and Environmental Specimens.
- Author
-
Eddyani, Miriam, Lavender, Caroline, de Rijk, Willem Bram, Bomans, Pieter, Fyfe, Janet, de Jong, Bouke, and Portaels, Françoise
- Subjects
- *
MYCOBACTERIUM , *DETECTION of microorganisms , *POLYMERASE chain reaction , *DIAGNOSTIC specimens , *BURULI ulcer , *PERFORMANCE evaluation , *MEDICAL microbiology - Abstract
Background: Mycobacterium ulcerans is the causative agent of Buruli ulcer (BU), a necrotizing disease of the skin, soft tissue and bone. PCR is increasingly used in the diagnosis of BU and in research on the mode of transmission and environmental reservoir of M. ulcerans. Methodology/Principal Findings: The aim of this study was to evaluate the performance of laboratories in detecting M. ulcerans using molecular tests in clinical and environmental samples by implementing sequential multicenter external quality assessment (EQA) programs. The second round of the clinical EQA program revealed somewhat improved performance. Conclusions/Significance: Ongoing EQA programs remain essential and continued participation in future EQA programs by laboratories involved in the molecular testing of clinical and environmental samples for M. ulcerans for diagnostic and research purposes is strongly encouraged. Broad participation in such EQA programs also benefits the harmonization of quality in the BU research community and enhances the credibility of advances made in solving the transmission enigma of M. ulcerans. [ABSTRACT FROM AUTHOR]
- Published
- 2014
- Full Text
- View/download PDF
37. Application of real-time PCR in Ghana, a Buruli ulcer-endemic country, confirms the presence of Mycobacterium ulcerans in the environment.
- Author
-
Vandelannoote, Koen, Durnez, Lies, Amissah, Diana, Gryseels, Sophie, Dodoo, Alfred, Yeboah, Shirley, Addo, Phyllis, Eddyani, Miriam, Leirs, Herwig, Ablordey, Anthony, and Portaels, Françoise
- Subjects
POLYMERASE chain reaction ,POLYMERIZATION ,MYCOBACTERIUM ,MYCOBACTERIA ,ULCERS ,MAMMALS ,MICROBIOLOGY ,BIOLOGY - Abstract
This study reports the first successful application of real-time PCR for the detection of Mycobacterium ulcerans, the causative agent of Buruli ulcer (BU), in Ghana, a BU-endemic country. Environmental samples and organs of small mammals were analyzed. The real-time PCR assays confirmed the presence of M. ulcerans in a water sample collected in a BU-endemic village in the Ashanti Region. [ABSTRACT FROM AUTHOR]
- Published
- 2010
- Full Text
- View/download PDF
38. Effects of Decontamination, DNA Extraction, and Amplification Procedures on the Molecular Diagnosis of Mycobacterium ulceransDisease (Buruli Ulcer)
- Author
-
Affolabi, Dissou, Sanoussi, N'Dira, Vandelannoote, Koen, Odoun, Mathieu, Faïhun, Frank, Sopoh, Ghislain, Anagonou, Séverin, Portaels, Françoise, and Eddyani, Miriam
- Abstract
ABSTRACTWe compared two DNA extraction methods (a semiautomated method using a Maxwell kit and a modified Boom method) and three amplification procedures (a single-step PCR, a nested PCR, and a real-time quantitative PCR) on 74 surgical tissue specimens from patients with clinically suspected Buruli ulcer. All of these procedures were compared before and after decontamination. We observed that, among the procedures tested, real-time PCR after the modified Boom extraction method or a single-run PCR assay after the Maxwell 16 extraction method, performed on nondecontaminated suspensions, are the best for the molecular diagnosis of Mycobacterium ulceransdisease.
- Published
- 2012
- Full Text
- View/download PDF
39. Primary Culture of Mycobacterium ulceransfrom Human Tissue Specimens after Storage in Semisolid Transport Medium
- Author
-
Eddyani, Miriam, Debacker, Martine, Martin, Anandi, Aguiar, Julia, Johnson, Christian R., Uwizeye, Ce´cile, Fissette, Krista, and Portaels, Franc¸oise
- Abstract
ABSTRACTTissue specimens collected from patients with clinically suspected Buruli ulcer treated in two Buruli ulcer treatment centers in Benin between 1998 and 2004 were placed in semisolid transport medium and transported at ambient temperature for microbiological analysis at the Institute of Tropical Medicine in Antwerp, Belgium. The impact of the delay before microbiological analysis on primary culture of Mycobacterium ulceranswas investigated. The length of storage in semisolid transport medium varied from 6 days to 26 weeks. Of the 1,273 tissue fragments positive for M. ulceransDNA by an IS2404-specific PCR, 576 (45.2%) yielded positive culture results. The sensitivity of direct smear examination was 64.6% (822/1,273 tissue fragments). The median time required to obtain a positive culture result was 11 weeks. Positive cultures were obtained even from samples kept for more than 2 months at ambient temperatures. Moreover, there was no reduction in the viability of M. ulcerans, as detected by culture, when specimens remained in semisolid transport medium for long periods of time (up to 26 weeks). We can conclude that the method with semisolid transport medium is very robust for clinical specimens from patients with Buruli ulcer that, due to circumstances, cannot be analyzed in a timely manner. This transport medium is thus very useful for the confirmation of a diagnosis of Buruli ulcer with specimens collected in the field.
- Published
- 2008
- Full Text
- View/download PDF
40. Subcutaneous Granulomatous Inflammation due to Basidiobolomycosis: Case Reports of 3 Patients in Buruli Ulcer Endemic Areas in Benin
- Author
-
V. C. Brun, Luc, Jacques Roux, Jean, E. Sopoh, Ghislain, Aguiar, Julia, Eddyani, Miriam, M. Meyers, Wayne, Stubbe, Dirk, T. Akele Akpo, Marie, Portaels, Françoise, and C. de Jong, Bouke
- Abstract
Background. Basidiobolomycosis is a rare subcutaneous mycosis, which can be mistaken for several other diseases, such as soft tissue tumors, lymphoma, or Buruli ulcer in the preulcerative stage. Microbiological confirmation by PCR for Basidiobolus ranarum and culture yield the most specific diagnosis, yet they are not widely available in endemic areas and with varying sensitivity. A combination of histopathological findings, namely, granulomatous inflammation with giant cells, septate hyphal fragments, and the Splendore-Hoeppli phenomenon, can confirm basidiobolomycosis in patients presenting with painless, hard induration of soft tissue. Case Presentations. We report on three patients misdiagnosed as suffering from Buruli ulcer, who did not respond to Buruli treatment. Histopathological review of the tissue sections from these patients suggests basidiobolomycosis. All patients had been lost to follow-up, and none received antifungal therapy. On visiting the patients at their homes, two were reported to have died of unknown causes. The third patient was found alive and well and had experienced local spontaneous healing. Conclusion. Basidiobolomycosis is a rare subcutaneous fungal disease mimicking preulcerative Buruli ulcer. We stress the importance of the early recognition by clinicians and pathologists of this treatable disease, so patients can timely receive antifungal therapy.
- Published
- 2018
- Full Text
- View/download PDF
41. Clearance of viable Mycobacterium ulcerans from Buruli ulcer lesions during antibiotic treatment as determined by combined 16S rRNA reverse transcriptase /IS 2404 qPCR assay.
- Author
-
Sarpong-Duah, Mabel, Frimpong, Michael, Beissner, Marcus, Saar, Malkin, Laing, Ken, Sarpong, Francisca, Loglo, Aloysius Dzigbordi, Abass, Kabiru Mohammed, Frempong, Margaret, Sarfo, Fred Stephen, Bretzel, Gisela, Wansbrough-Jones, Mark, and Phillips, Richard Odame
- Subjects
BURULI ulcer ,MYCOBACTERIUM ,RIBOSOMAL RNA ,MANN Whitney U Test ,KAPLAN-Meier estimator - Abstract
Introduction: Buruli ulcer (BU) caused by Mycobacterium ulcerans is effectively treated with rifampicin and streptomycin for 8 weeks but some lesions take several months to heal. We have shown previously that some slowly healing lesions contain mycolactone suggesting continuing infection after antibiotic therapy. Now we have determined how rapidly combined M. ulcerans 16S rRNA reverse transcriptase / IS2404 qPCR assay (16S rRNA) became negative during antibiotic treatment and investigated its influence on healing. Methods: Fine needle aspirates and swab samples were obtained for culture, acid fast bacilli (AFB) and detection of M. ulcerans 16S rRNA and IS2404 by qPCR (16S rRNA) from patients with IS2404 PCR confirmed BU at baseline, during antibiotic and after treatment. Patients were followed up at 2 weekly intervals to determine the rate of healing. The Kaplan-Meier survival analysis was used to analyse the time to clearance of M. ulcerans 16S rRNA and the influence of persistent M ulcerans 16S rRNA on time to healing. The Mann Whitney test was used to compare the bacillary load at baseline in patients with or without viable organisms at week 4, and to analyse rate of healing at week 4 in relation to detection of viable organisms. Results: Out of 129 patients, 16S rRNA was detected in 65% of lesions at baseline. The M. ulcerans 16S rRNA remained positive in 78% of patients with unhealed lesions at 4 weeks, 52% at 8 weeks, 23% at 12 weeks and 10% at week 16. The median time to clearance of M. ulcerans 16S rRNA was 12 weeks. BU lesions with positive 16S rRNA after antibiotic treatment had significantly higher bacterial load at baseline, longer healing time and lower healing rate at week 4 compared with those in which 16S rRNA was not detected at baseline or had become undetectable by week 4. Conclusions: Current antibiotic therapy for BU is highly successful in most patients but it may be possible to abbreviate treatment to 4 weeks in patients with a low initial bacterial load. On the other hand persistent infection contributes to slow healing in patients with a high bacterial load at baseline, some of whom may need antibiotic treatment extended beyond 8 weeks. Bacterial load was estimated from a single sample taken at baseline. A better estimate could be made by taking multiple samples or biopsies but this was not ethically acceptable. [ABSTRACT FROM AUTHOR]
- Published
- 2017
- Full Text
- View/download PDF
42. Acknowledgement to Reviewers of IJERPH in 2016.
- Published
- 2017
- Full Text
- View/download PDF
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.