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Background: Although several materials have been used for retrograde filling following apical surgeries, there is no consensus on a single best material. Tricalcium silicate-based types of cement have been developed as root-end filling materials mainly due to tricalcium silicate's hydraulic properties. However, its unfavorable setting characteristics and minimal antimicrobial properties have necessitated the introduction of new additives into the existing commercially available materials. To design an affordable product based on a dicalcium silicate with a shorter set time, minimal cytotoxic complications, and enhanced antibacterial activity, we developed a new endodontic cement from pure raw materials, intending to satisfy the prerequisites of ideal retrograde material., Methods: The composition of the experimental calcium silicate-based cement included the addition of calcium chloride and silver nanoparticles in varying concentrations. Structural characterization was carried out using energy dispersive analysis by X-rays using scanning electron microscope (EDAX SEM) and hydration characteristics were performed using an X-ray diffractometer (XRD). The experimental material was further evaluated for biocompatibility using MTT ([3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazolium bromide)assay and antibacterial activity was evaluated using an agar diffusion test against Enterococcus faecalis ., Results: The structural characterization and hydration characteristics revealed that the experimental cement was dicalcium silicate based with favorable biocompatibility and enhanced antibacterial activity. Tricalcium silicate based mineral trioxide aggregate (MTA) also had favourable biocompatibility, however, its antibacterial activity was significantly decreased when compared to the novel cement., Conclusion: All hydraulic cements that are available in the dental market are predominantly tricalcium silicate-based materials. There has been no evidence in the literature to date wherein it has been explored whether a dicalcium silicate-based hydraulic cement can solely be used in root-end cavities. The findings of the study revealed a dicalcium silicate based retrograde filling material with favourable biocompatibility exhibited immediately as well as in the set samples. Incorporation of silver nanoparticles boosted the antibacterial activity when compared to that of ProRoot MTA. This material could potentially reinstate the usual hype created with tricalcium silicate types of cement since dicalcium silicate cements also exhibit similar properties., Competing Interests: The authors declare there are no competing interests., (©2023 Dsouza et al.)

Purpose: Arthroscopic capsular release (ACR) and Manipulation under anaesthesia(MUA) have been widely used in the treatment of frozen shoulder (FS). However, there is only limited Level-I evidence to prefer ACR over MUA. The purpose of our study was to conduct a randomised trial comparing ACR versus MUA to assess the difference in outcome, complications and cost-effectiveness of both procedures., Methods: From May 2020 to June 2021, patients presenting with FS were randomised into two groups ACR (n = 44) and MUA (n = 41). Patients with arthritis, full-thickness cuff tears, history of trauma/previous surgery around the shoulder were excluded from the study. Range of movement (ROM), pain grading using visual analogue scale (VAS), functional scores- UCLA, CONSTANT and EuroQol-5D scores were measured pre-operatively and post-operatively. MRI was done at three weeks post-operatively for screening complications of either procedure. Quality-adjusted life years (QALY) was used for cost-analysis., Results: Post-operatively, patients had significant improvement in pain, ROM and functional scores in both groups (P < 0.001) with no significant difference between groups at 24 weeks of follow-up. Diabetic patients undergoing ACR had lesser improvement in abduction and external rotation when compared to non-diabetic patients. Labral tears in MUA group and bone bruises in ACR group were the most common complications noted on the post-operative MRI. For ACR cost per QALY gained was 896 USD while that for MUA was 424 USD., Conclusion: Both ACR and MUA resulted in good improvement in pain and shoulder function. Good outcomes, simple technique and better cost-effectiveness would still make MUA an attractive option over ACR for treating FS., (© 2022. The Author(s) under exclusive licence to SICOT aisbl.)

Background: Association of tendon degeneration, pre-existing posterior heel pain, Haglund's bump, retrocalcaneal spur, and mode of injury varies for the insertional and non-insertional type of tendoachilles tears (TA)., Purpose: The study compares the various predisposing factors that determine the distinct type of TA tear and the outcome following a repair., Methods: This is a retrospective study of the patients who underwent tendoachilles repair during January 2012-June 2018. Patients above 18 years with a minimum follow-up of two years were included. Patients with calcaneal tuberosity avulsions, prior surgeries, and open injuries were excluded. Patients were divided into groups 1 (insertional tears (IT)) and 2 (non-insertional tears (NIT)), and further subdivided based on the tendon degeneration (as D-degenerative and N-normal sub types) from ultrasound findings. AOFAS score and predisposing factors like degeneration, posterior heel pain, Haglund's bump, spur, and mechanism of injury were compared between the groups., Results: The study included N = 146 with a mean age of 51.6 years and mean follow-up of 38.6 (range 24 to 96) months. IT associated with degeneration (IT-D) had a trivial fall as the predominant mechanism (P < 0.001). All patients had significant postoperative improvement of scores with no significant difference between the groups (P = 0.59) and subgroups (P = 0.27).75.34% had degenerative tendon, of which 64.5% were in the IT group and the rest in the NIT group (P = 0.02). 51.4% patients had a Haglund bump in the IT group and n.s. (P = 0.9). Forty-seven percent of patients had pre-existing posterior heel pain, 68% in IT and 32% in NIT (P = 0.04). Subgroup analysis revealed 65% of patients were in the IT-D subgroup (P < 0.001)., Conclusion: Predisposing factors like posterior heel pain, tendon degeneration, and trivial trauma have a strong propensity for insertional TA tear. In contrast, the prominence of Haglund's bump does not predispose to a distinct type of TA tears. The outcome following a surgical repair-yields good results with no difference between the two groups., (© 2022. The Author(s) under exclusive licence to SICOT aisbl.)

An experimental calcium silicate-based root-end filling material incorporated with silver nanoparticles intended for use in periapical surgeries was developed with the purpose to overcome the drawbacks of existing materials and to satisfy the ideal requirements of root-end filling materials. This study was designed to evaluate the physicochemical properties, pH, calcium ion release, and dimensional stability of the experimental cement, and compare the results with commercially available ProRoot MTA (Dentsply). An independent sample test was used to analyze the data. Mean initial pH (immediately after mixing) of the experimental cement was 10.42 ± 0.04 which was higher than that of MTA. However, there was a significant increase in pH of MTA at 1 day, 2 days, and 7 days. Presence of calcium chloride favored the release of calcium ions which was significantly increased in the experimental group at 24 hours. At the end of 30 days, MTA showed a significant expansion when compared to the experimental cement ( p < 0.001). In conclusion, the experimental nanoparticle-incorporated calcium silicate-based cement showed clinically acceptable physicochemical properties., Competing Interests: The authors declare that they have no conflicts of interest., (Copyright © 2021 Teena Sheethal Dsouza et al.)

Multiligament knee injury with periarticular fractures are high-velocity injuries and generally require a staged treatment approach that involves multiple hospitalizations and results in delayed return to activity. We report a single-stage management technique for these injuries with arthroscopy-assisted reduction and internal fixation of a depressed tibial rim fracture with concomitant posterolateral complex repair, medial meniscal repair, and posterior cruciate ligament reconstruction., (© 2021 by the Arthroscopy Association of North America. Published by Elsevier.)

Objective: Frozen shoulder (FS) is a painful and debilitating condition affecting the shoulder joint. When patients fail to improve after conservative treatments, operative treatments including arthroscopic capsular release (ACR) and manipulation under anesthesia (MUA) are recommended. However, the comparison between these two interventions remains controversial. This study aimed to compare the efficacy and safety of ACR and MUA for refractory FS. Methods: A systematic review and meta‐analysis was conducted following the Preferred Reporting Items for Systematic Review and Meta‐analyses (PRISMA) guidelines. PubMed, EMBASE, Cochrane Library, and Web of Science were searched for eligible studies until December 10, 2023. Meta‐analyses were conducted using Manager V.5.3.3. Pooled effect sizes were expressed as the weighted mean difference (WMD) or odds ratio (OR) with 95% confidence intervals (CIs). Results: A total of eight comparative studies with 768 patients were included. Compared with MUA, ACR had statistically better Δ VAS (WMD, −0.44; 95% CI, −0.71 to −0.18; I2 = 6%; p = 0.001) at over 12‐month follow‐up, which did not reach the minimal clinically important difference (MCID). Other outcomes regarding pain relief, function, and range of motion (ROM) improvements were not statistically different between the two groups at different follow‐up timepoints. Compared with the MUA group, the ACR group had a significantly higher rate of severe complications (OR, 4.14; 95% CI, 1.01 to 16.94; I2 = 0%; p = 0.05), but comparable rates of mild complications and additional intervention. Conclusions: In treating refractory FS, ACR demonstrated comparable pain relief, functional and ROM improvements, rates of mild complications and additional intervention but a higher risk of severe complications to MUA during short‐term follow‐up periods. Notably, ACR exhibited statistically superior improvement in the long‐term pain relief compared to the MUA group, although it did not reach the MCID. [ABSTRACT FROM AUTHOR]

The direct relationship existing between the average rate constant 〈k〉 for pyrene excimer formation and the local concentration [Py]loc of ground-state pyrenyl labels covalently attached to a macromolecule was established for 55 pyrene-labeled macromolecules (PyLM). These PyLM belonged to three different families of macromolecules with the first representing short monodisperse linear chains end-labeled with pyrene (polystyrene, poly(ethylene oxide), and poly(N-isopropyl acrylamide)), the second representing long polydisperse linear chains randomly labeled with pyrene (poly(methyl acrylate), poly(methyl methacrylate), polystyrene, poly(butyl methacrylate), poly(methoxyethyl methacrylate), and poly(N-isopropyl acrylamide)), and the third being comprised of two series of pyrene end-labeled low generation dendrimers with a bis(hydroxymethyl)propionic acid or a polyamidoamine backbone. The assumption, that the polymeric segments probed by an excited pyrenyl label covalently attached to one of these macromolecules obeyed Gaussian statistics, enabled the calculation of their square root average squared end-to-end distance (LPy), which was applied to calculate [Py]loc. The log–log plots of 〈k〉 as a function of [Py]loc yielded straight lines with a slope of unity for all families of macromolecules studied in four different organic solvents demonstrating the validity and generality of the 〈k〉-vs.-[Py]loc relationship. Since an experimentalist knows how the the pyrenyl labels are covalently attached onto a macromolecule, [Py]loc offers a means to probe the local density of a macromolecule, which can be employed to characterize its conformation in solution. Consequently, the 〈k〉-vs.-[Py]loc relationship provides a novel experimental means to probe the conformation of macromolecules which should establish pyrene excimer formation as an appealing method for conformational studies of macromolecules in solution, which should nicely complement scattering techniques. [ABSTRACT FROM AUTHOR]

The purpose of the study was to evaluate the production of lignin-modifying enzyme extracts and delignified biomass from agro-industrial wastes using white rot fungi (Inonotus sp. Sp2, Stereum hirsutum Ru-104, Bjerkandera sp. BOS55, Pleurotus eryngii IJFM 169 and Phanerochaete chrysosporium BKM-F-1767). These were screened based on their adaptability and colonization ability on different substrates, as well as by the Laccase, Manganese peroxidase, and Lignin peroxidase enzymatic production. Native strains (Inonotus sp. Sp2 and S. hirsutum Ru-104) showed the highest growth kinetics under the solid-substrate fermentation conditions and the growth rate parameters of the kinetic logistic model for the different substrates were between 0.39–0.81 (1/d) and 0.42–0.83 (1/d), respectively; the determination coefficients were ≥0.99. Inonotus sp. Sp2 was subsequently cultured in static flasks to produce crude enzyme extracts, obtaining manganese peroxidase activity levels of 18.5 and 31.3 (U/g) when growing in corn cob husk and spent tea leaves, respectively. Besides, it was to establish that the best conditions for lignin-modifying enzymes production using corn cob husk are 70% of initial moisture and 2.12 mm of particle size; reaching after 30 incubation days a manganese peroxidase activity of 21 ± 6 (U/g) under these conditions; enzyme that showed a suitable thermostability. [ABSTRACT FROM AUTHOR]

Background: While Achilles tendon rupture is a common injury sustained especially in sporting events, distal Achilles tendon rupture is less common. Even rarer is a bilateral traumatic distal Achilles tendon sleeve rupture, with outcomes of such injury unknown. The following case report describes this rare injury, not reported to date elsewhere. Case: A 57-year-old Finnish man with no predisposing medical history had a traumatic bilateral distal Achilles tendon sleeve avulsion injury. Clinical and radiological evaluation confirmed the diagnosis. Treatment included suture anchors in a modified suture bridge style with customized rehabilitation protocol postoperatively. Symptoms continued to be relieved at 1 year postoperatively. Conclusion: A modified suture bridge style and meticulous rehabilitation protocol including motivated patient contributed to very satisfying results in this very rare bilateral injury. [ABSTRACT FROM AUTHOR]

The efficient elimination of microorganisms and their byproducts from infected root canals is compromised by the limitations in conventional root canal disinfection strategies and antimicrobials. Silver nanoparticles (AgNPs) are advantageous for root canal disinfection, mainly due to their wide-spectrum anti-microbial activity. Compared to other commonly used nanoparticulate antibacterials, AgNPs have acceptable antibacterial properties and relatively low cytotoxicity. Owing to their nano-scale, AgNPs penetrate deeper into the complexities of the root canal systems and dentinal tubules, as well as enhancing the antibacterial properties of endodontic irrigants and sealers. AgNPs gradually increase the dentin hardness in endodontically treated teeth and promote antibacterial properties when used as a carrier for intracanal medication. The unique properties of AgNPs make them an ideal additive for different endodontic biomaterials. However, the possible side effects of AgNPs, such as cytotoxicity and tooth discoloration potential, merits further research. [ABSTRACT FROM AUTHOR]

Dentinal hypersensitivity or cervical dentinal sensitivity is one of the commonest clinical problems. The aim of this randomized controlled trial was to evaluate the effectiveness of a single chair side application of 100% pure calcium sodium phosphosilicate (NovaMin®) in reducing dentin hypersensitivity following ultrasonic scaling as evaluated on a visual analogue scale (VAS). The study included 50 subjects who were selected based on an evaluation of dentinal hypersensitivity on a VAS carried out using a metered air blast from a three-way syringe and divided into two groups (n = 25/group); i.e., the test group (Group A) received the NovaMin® paste and the control group (Group B) received a placebo paste made from pumice. All the 50 subjects included in the study were had VAS scores of 3 or more. The NovaMin® powder mixed with distilled water was applied. Dentinal hypersensitivity was reassessed immediately and after 1, 2 and 4 weeks after the procedure. Results showed that the percentage reduction of dentinal hypersensitivity following a single application of NovaMin® in powder form was about 76.38% immediately, 67.72% one week postoperatively, 52.76% two weeks postoperatively and 26.78% four weeks postoperatively. It can be concluded from the results of the current clinical study demonstrated that a single chair side application of NovaMin® in powder form has a significant and immediate reduction in dentinal hypersensitivity, which lasted nearly for four weeks. [ABSTRACT FROM AUTHOR]

The objective was to compare the strain of three calcium silicate cements using an optical system based on the 3D digital image correlation method (3D-DIC). Dentine disks from 30 upper premolars were sectioned transversely to obtain 2 mm-thick sections and enlarged with a 4 mm diameter bur. An additional 30 samples were made in Teflon molds (4 × 2 mm). Dentine discs and Teflon molds were divided into three groups with ten samples each and then filled with MTA+ (Cerkamed), Biodentine (Septodont) and Well-Root PT (Vericom). The strain was determined using the 3D-DIC method in two zones: the peripheral and central zones. Data were analyzed using ANOVA with Scheffe's post hoc test, a paired t-test and Pearson correlation (α = 0.05). Analysis showed that there were significant differences in the values of deformation between all tested materials in both zones. Comparing the strain in both zones, there were significant differences between zones in the Biodentin and Well-Root PT group on dentine discs, and in the Biodentine and MTA group on Teflon discs. Comparing the strain measured on different disc types, the higher values were found on Teflon. All the examined calcium silicate-based cements showed deformation after initial setting. The highest strain was recorded for Biodentine and the lowest was for Well-Root PT. [ABSTRACT FROM AUTHOR]

We report an efficient iron-catalyzed cycloaddition procedure leading to the construction of (hetero)aromatic rings by alkyne [2+2+2] cycloisomerization. This method relies on the use of an air-stable (N,N)Fe(II) precursor easily prepared from a commercially available ligand derived from 1,10-phenanthroline, reduced in situ into a catalytically active non-innocent (N,N ⋅ - ) 2 Fe(II) species. This system displays a large scope application, operates under mild conditions and at low catalytic charges (25 cycloadducts formed, up to 1.5 mol% catalyst). Moreover, this method also enables access to 29 cycloadducts by cross-cycloisomerization between 1,6- or 1,7-diynes and alkynes in near-equimolar conditions. 1,3,5-Triazines can also be prepared with this procedure starting from the corresponding cyanamides. Scale-up reactions and post-functionalization of several cycloadducts also show that this [2+2+2] cycloaddition can be used in multistep sequences., (© 2024 Wiley‐VCH GmbH.)

In high school settings, the small learning community (SLC) concept often manifests in the form of career academies. Career academies function as SLCs organized around career and technical education (CTE) themes; although, CTE is often misunderstood. This study examined a community outreach campaign that used traditional and nontraditional advertising and marketing outlets to combat negative media attention toward career academies. All media outlets examined were effective at reaching the targeted community, yielding a positive response in calls to action. Continued research is needed to better understand how advertising and marketing can be utilized in public education, specifically with combating negative views toward CTE. [ABSTRACT FROM AUTHOR]

Traditional Chinese medicine is one of the ancient medicines which is popular in Asian countries, among which the residue produced by the use of anti-biodegradables is endless, and causes significant adverse impacts on the environment. However, the high acidity of anti-biodegradable residues and some special biological activities make it difficult for microorganisms to survive, resulting in a very low degradation rate of lignocellulose in naturally stacked residues, which directly impedes the degradation of residues. We aimed to identify the fungal strains that efficiently biodegrade anti-biodegradable residue and see the possibility to improve the biodegradation of it and other agricultural wastes by co-cultivating these fungi. We isolated 302 fungal strains from anti-biodegradable residue to test hydrolysis ability. Finally, we found Coniochaeta sp., Fomitopsis sp., Nemania sp., Talaromyces sp., Phaeophlebiopsis sp. which inhabit the anti-biodegradable residues are capable of producing higher concentrations of extracellular enzymes. Synergistic fungal combinations (viz., Fomitopsis sp. + Phaeophlebiopsis sp.; Talaromyces sp. + Coniochaeta sp. + Fomitopsis sp.; Talaromyces sp. + Fomitopsis sp. + Piloderma sp. and Talaromyces sp. + Nemania sp. + Piloderma sp.) have better overall degradation effect on lignocellulose. Therefore, these fungi and their combinations have strong potential to be further developed for bioremediation and biological enzyme industrial production. [ABSTRACT FROM AUTHOR]

Background: Anteromedial tibial plateau fracture with posterolateral corner (PLC) injury is a relatively rare combined injury in the clinic. In addition, there is no unified treatment scheme for this combined injury. The purpose of this study was to evaluate the clinical and imaging results of single-stage arthroscopic-assisted surgery for anteromedial tibial plateau fracture with PLC injury, and to explore the advantages of this surgical technique.Method: In this retrospective study, a total of 9 patients (7 males and 2 females) were included, aged 24-64 years (average 40.7 years), treated in our Department of Orthopedics from January 2016 to January 2021. In the preoperative evaluations, there were 9 cases of anteromedial tibial plateau fractures with PLC injuries, 6 cases of concomitant PCL injuries, 6 cases of concomitant medial or lateral meniscus injuries, and 2 cases of concomitant fibular head avulsion fractures. All patients underwent single-stage arthroscopic-assisted surgery.Results: All patients were followed up, and the average follow-up period was 15.2 months (range 12-18 months). The average operation time was 135.6 min (range 100-160 min), and the average surgical blood loss was 87.2 ml (range 60-110 ml). The anatomical reduction was achieved in 9 cases, and the anatomical reduction rate was 100%. The average fracture healing time was 13.1 weeks (range 12-16 weeks). At the last follow-up, the average VAS score was 1 (range 0-2); the average Lysholm function score was 90.7 (range 86-95), and the average IKDC score was 91.4 (range 88-95); the average knee extension angle of all patients was 0° and the average knee flexion angle was 128.3° (average 120-135°); The posterior drawer test, the Lachman test and the dial test were negative for all cases. None of the patients had operation-related complications.Conclusion: Single-stage arthroscopy-assisted surgery in the treatment of anteromedial tibial plateau fracture with PLC injury can achieve good clinical outcomes, restore the stability of the knee joint, and reduce the risk of severe lower extremity dysfunction. [ABSTRACT FROM AUTHOR]

Purpose: A major part of knowledge management for knowledge-intensive firms such as professional service firms is the increasing focus on thought leadership. Despite being a well-known term, it is poorly defined and analysed in the academic and practitioner literature. The aim of this article is to answer three questions. First, what is thought leadership? Second, what tensions exist when seeking to create thought leadership in knowledge-based organisations? Third, what further research is needed about thought leadership? The authors call for cross-disciplinary and academic–practitioner approaches to understanding the field of thought leadership. Design/methodology/approach: The authors review the academic and practitioner literature on thought leadership to provide a rich oversight of how it is defined and can be understood by separating inputs, creation processes and outcomes. The authors also draw on qualitative data from 12 in-depth interviews with senior leaders of professional service firms. Findings: Through analysing and building on previous understandings of the concept, the authors redefine thought leadership as follows: "Knowledge from a trusted, eminent and authoritative source that is actionable and provides valuable solutions for stakeholders". The authors find and explore nine tensions that developing thought leadership creates and propose a framework for understanding how to engage with thought leadership at the industry/macro, organisational/meso and individual/micro levels. The authors propose a research agenda based on testing propositions derived from new theories to explain thought leadership, including leadership, reducing risk, signalling quality and managing social networks, as well as examining the suggested ways to resolve different tensions. Originality/value: To the best of the authors' knowledge, they are the first to separate out thought leadership from its inputs, creation processes and outcomes. The authors show new organisational paradoxes within thought leadership and show how they can play out at different levels of analysis when implementing a thought leadership strategy. This work on thought leadership is set in a relatively under-explored context for knowledge management researchers, namely, knowledge-intensive professional service firms. [ABSTRACT FROM AUTHOR]

The paper aims to evaluate the performance of the Lagrange-based finite element method and the non-uniform rational B-splines isogeometric analysis of time-harmonic acoustic exterior scattering problems using high-order local absorbing boundary conditions, in particular based on the Karp's and Wilcox's far-field expansions. The analysis of accuracy and convergence of both methods is achieved by observing the effect of the order of the approximating polynomial, the number of degrees of freedom, the wave number, and the absorbing boundary conditions tuning parameters. It is concluded that, regardless of the polynomial order, IGA provides a higher accuracy per degree of freedom compared to the traditional Lagrange-based finite element method. [ABSTRACT FROM AUTHOR]

Production of an extracellular thermophilic and alkali stable laccase from Phoma herbarum isolate KU4 was reported for the first time, both in submerged fermentation (SmF, highest 1590 U/mL) and solid state fermentation (SSF, highest 2014.21 U/mL) using agro-industrial residues. The laccase was partially purified to 7.93 fold with the apparent molecular weight of 298 kDa. The enzyme had pH optimum at 5.0 and temperature optimum at 50 °C, with maximum stability at pH 8.0. It showed activity towards various phenolic and non-phenolic compounds. The kinetic parameters, Km, Vmax and Kcat of the laccase for DMP were 0.216 mM, 270.27 U/mg and 506.69 s−1, respectively. Laccase activity was inhibited by various metal ions and conventional inhibitors, however, it was slightly increased by Zn2+. The laccase showed good decolorization efficiency towards four industrial dyes, namely, methyl violet (75.66%), methyl green (65%), indigo carmine (58%) and neutral red (42%) within 24 h. FTIR analysis of the decolorized products confirmed the degradation of the dyes. The decolorization efficiency of the enzyme suggests that the partially purified laccase could be used to decolorize synthetic dyes present in industrial effluents and for waste water treatments. The thermophilic and alkali stable laccase may also have wider potential industrial applications. [ABSTRACT FROM AUTHOR]

The electronic and adsorption properties of the zigzag‐edged triangle graphene nanosheets with different size are investigated, including the calculation of the adsorption energy, sensitivity and recovery time after adsorbing CO2, NO2, CH4 and CO. The results show that the quantum size effect is satisfied in the triangle graphene nanosheets, and its conductivity type can be changed from p to n. In addition, the triangle graphene nanosheets with n = 5 has the highest sensitivity to NO2 (374.79%), which is more than 300 times as compared to the lowest one. The recovery time of triangle graphene nanosheets with n = 4 is the shortest, and its sensitivity and recovery time are the best at 144 K. These results reveal that the zigzag‐edged triangular graphene nanosheets can serve as the fundamental structural unit for the design of high sensitivity gas sensors. [ABSTRACT FROM AUTHOR]

Magneto‐caloric materials offer the possibility to design environmentally friendlier thermal management devices compared to the widely used gas‐based systems. The challenges to develop this solid‐state based technology lie in the difficulty of finding materials presenting a large magneto‐caloric effect over a broad temperature span together with suitable secondary application parameters such as low heat capacity and high thermal conductivity. A series of compounds derived from the PbFCl structure is investigated using a combination of computational and experimental methods focusing on the change of cell volume in magnetic and non‐magnetic ground states. Scaling analysis of the magnetic properties determines that they are second order phase transition ferromagnets and that the magnetic entropy change is driven by the coupling of magneto‐elastic strain in the square‐net through the magnetic transition determined from neutron and synchrotron X‐ray diffraction. The primary and secondary application related properties are measured experimentally, and the c/a parameter is identified as an accurate proxy to control the magnetic transition. Chemical substitution on the square‐net affords tuning of the Curie temperature over a broad temperature span between 252 and 322 K. A predictive machine learning model for the c/a parameter is developed to guide future exploratory synthesis. [ABSTRACT FROM AUTHOR]

In this work, seven indigenous macrofungal isolates were selected to screen for their laccase production capability. Among them, isolates viz., Pleurotus eryngii, Pleurotus florida, Pleurotus sajor caju and Gandoderma lucidum were found to exhibit high laccase activity in the preliminary studies and were thus selected for the optimization studies with an aim to enhance laccase production. The pH optimization studies were carried out between pH range of 4–6. The laccase activity and biomass were found to be optimum at pH 4, 4.5, 4.5 and 5 for P. eryngii, P. florida, P. sajor caju and G. lucidum, respectively. Optimization studies with chemical inducers namely, tannic acid, 2,6 dimethoxyphenol and copper sulphate at three different concentration levels were conducted and tannic acid at 2 mM concentration was found to increase the laccase activity to about 45% followed by 2,6 dimethoxyphenol (2 mM) with an increase of about 43% and copper sulphate (0.1 mM) showing 21% increase in the yield. Biodegradation studies utilizing laccase isolated from P. eryngii, P. florida and P. sajor caju was carried out for a commonly detected fluoroquinolone antibiotic, levofloxacin, in water and pharmaceutical wastewater. The results indicated that the degradation efficiency of levofloxacin using laccase isolated from P. eryngii (88.9%) was comparable to commercial laccase (89%). When the cost economics of using crude laccase was evaluated against commercial laccase it was evident that the total cost of the treatment could be reduced by 71.7% if commercial grade laccase was replaced by crude enzyme extracted from indigenous macrofungi such Pleurotus eryngii, Pleurotus florida, and Pleurotus sajor caju indicating a promising and cost-effective alternative for wastewater treatment. [ABSTRACT FROM AUTHOR]

Creative workers in media industries work under particular employment conditions and structures that can be described as "atypical employment". For most of the creative workforce, employment is not full-time, and the average annual income is low and unpredictable. It is important for the creative workforce to know that reputation plays a decisive role in overcoming barriers of entry to networks, and obstacles to employment in artistic-creative projects. Thus, it is crucial to learn how reputational capital can be built, developed, preserved and expanded. Therefore, this paper will present a theoretical framework for reputation management that demonstrates the complex cause-and-effect relationships among a creative worker's reputational capital as an intangible resource in a media network. It will be shown that a creative worker's personal branding has instrumental value for the development and maintenance of reputational capital. Moreover, this paper conceptualises reputation management based on a review of related literature for the purpose of conceptual development. [ABSTRACT FROM AUTHOR]

Purpose: The purpose of this paper is to examine the impact of microblogging word of mouth (MWOM) through twitter on value co-destruction for Athens, as a tourism destination facing a sustained crisis. The study demonstrates the sentiment and sharing evolution of tweets, illustrating the value co-destruction of a tourism destination. Overall, the study expands understanding on the online footprints of MWOM in the field of tourism. Design/methodology/approach: It uses social media focused data mining and sentiment analysis, to analyze more than 90,000 tweets posted by top twitter influencers between 2013 and 2015. The methodology that the authors have adopted follows seven steps: first, identification of the top-5 twitter influencers who use the hashtag #Athens, based on their klout score; second, collection of tweets from the top-5 twitter influencers, for the period from January 2013 until June 2015; third, collection of the retweets metadata of the above tweets and of the corresponding retweeter accounts (i.e. user id, name, screen name), together with the frequency of retweeting per tweet; fourth, collection of user metadata (i.e. location and number of followers) from the retweeter accounts; fifth, influence computation of retweetwers using their klout score; sixth, tweets classification based on the klout score of their retweeters; and seventh, sentiment analysis of the collected tweets. Findings: The findings show the high potential of value co-destruction in virtual environments, through negative MWOM related to tourism destinations in crisis, and shared among highly influencing users, that disseminate negative stories through microblogging. The findings also reveal the existence of negativity bias that can reduce the risks of visiting a new destination facing a crisis and, at the same time, significantly destroy the destination's value. Originality/value: This is the first study to examine the impact of MWOM through twitter on a tourism destination facing a sustained crisis, such as Athens. This study uses social media focused data mining and sentiment analysis, to analyze more than 90,000 tweets posted by top twitter influencers between 2013 and 2015. The findings reveal the existence of negativity bias that can reduce the risks of visiting a new destination facing a crisis and, at the same time, significantly destroy the destination's value. [ABSTRACT FROM AUTHOR]

In this paper, we introduce a methodology for improving the targeting of marketing campaigns using bridge prediction in communities based on the information of multilayer online social networks. The campaign strategy involves the identification of nodes with high brand loyalty and top-ranking nodes in terms of participation in bridges that will be involved in the evolution of the graph. Our approach is based on an efficient classification model combining topological characteristics of crawled social graphs with sentiment and linguistic traits of user-nodes, popularity in social media as well as meta path-based features of multilayer networks. To validate our approach we present a set of experimental results using a well-defined dataset from Twitter and Foursquare. Our methodology is useful to recommendation systems as well as to marketers who are interested to use social influence and run effective marketing campaigns. [ABSTRACT FROM AUTHOR]

High influential users are playing an important role in promoting information propagation in social media. Thus, it has been a very interesting problem to identify influential users in social media, and attracted numerous researchers. A great deal of research work has been devoted to solving this problem. However, the existing methods mainly focus on the network topology, ignoring users' behaviors. In this paper, we propose an High Influential Users Detection (HIUD) algorithm by analyzing users' behaviors. To evaluate the performance of our algorithm, we carry out extensive experiments on Sina and Tencent microblogging data sets, and compare it with other methods. The experimental results have shown that the HIUD achieves the best performance. Furthermore, we also make a spatial analysis on those high influential users with thermodynamic map. [ABSTRACT FROM AUTHOR]

Purpose: The purpose of this paper is to analyze the moderating effects of the social influence of the blogger and the extent to which the reader has experience of that blogger, on loyalty toward the blogger, via two variables: blogger interactive practices (BIPs) and blogger credibility. Design/methodology/approach: A quantitative empirical study was undertaken to estimate the research model. Structural equations were employed. Findings: The results show that blogger social influence moderates the relationships between BIPs and intention to recommend the blogger and blogger credibility; and between credibility and intention (to recommend the blogger and to follow their suggestions). Meanwhile, the extent of the reader's experience of the blogger moderates the relationships between BIPs and intention. Practical implications: The present work offers criteria that may be of value to bloggers and firms in assessing the extent to which the blogger's activities are effective in terms of achieving reader loyalty. The proposed variables are measured objectively online, using the Klout Index of social influence and the extent of the reader's experience of the blogger (inferred from the number of bloggers followed by the reader). Originality/value: Blogs are considered a mechanism to manage information overload in social media, and they are recognized for their influence on the reader's decision-making process. The study contributes to the knowledge-base by proposing two moderating variables of loyalty-formation: blogger social influence and the extent of the reader's experience of the blogger. [ABSTRACT FROM AUTHOR]

This study investigates the impact created upon firm value when social media, in an emerging market context. Social media enables communication with stakeholders in terms of financial and non-financial achievements, as well as issues of organization at low cost, in a direct and timely manner; thus, the study draws attention to the new phenomenon of enhanced value to firms through the use of social media. The sample consists of Turkish corporations listed on the BIST 100 Index of Borsa Istanbul for the year 2014, utilizing three metrics regarding social media usage: establishment of a social media account, the breadth of social media engagement, and the depth of social media engagement. The results demonstrate that depth of social media engagement has a significant positive association with firm value; whereas social media account ownership per se, and breadth of social media engagement do not show a viable statistical relationship. These findings imply that if social media accounts are opened and icons for several social media are placed on corporate websites, which is presently a fad and fashion, a benefit may not necessarily accrue. However, strong engagement for corporate purposes will generate the desired results and benefits. Thus, the study provides implications and guidance for firms which are using social media currently or thinking of using it in the future. [ABSTRACT FROM AUTHOR]

In this article the design and characterization of a set of novel red‐light‐emitting laser aza‐BODIPY dyes is reported. The applied synthetic method allows an exhaustive and versatile functionalization of both the dipyrrin core and the boron bridge. From the analysis of the photophysical and laser signatures, we determine the suitable modifications of the chromophoric backbone necessary to modulate the emission spectral region, efficiency and photostability under a strong irradiation regime. These dyes are endowed with efficient fluorescence and laser emission, and are particularly outstanding in terms of their high photostability, a key parameter to guarantee long‐lasting emission in any (bio)technological application. The herein‐reported results support, for the first time, the viability of aza‐BODIPYs as tunable red laser dyes. In fact, the laser performances of some of the tested aza‐BODIPYs surpass those of commercially available laser dyes in the same spectral region. Live long and glow: From the conducted computationally aided photophysical properties and the recording of the laser signatures, the structural guidelines which rule the emission properties of aza‐BODIPYs are determined. Some of the reported dyes display tunable, efficient and photostable laser emission at the red edge, surpassing the performance of commercially available laser dyes in this spectral window. [ABSTRACT FROM AUTHOR]

Abstract: We study pricing strategies of competing firms selling heterogeneous products to consumers. Goods are substitutes and there are network externalities between neighboring consumers. In equilibrium, firms price discriminate based on the network positions and charge lower prices to more central consumers. We also show that, under some conditions, firms' equilibrium profits decrease when either the network becomes denser or network effects increase. In contrast, consumers always benefit from being more connected to each other. We determine the optimal network structure and compare uniform pricing and discriminatory pricing from the perspectives of firms and consumers. [ABSTRACT FROM AUTHOR]

Abstract: Because of the crucial role of ligninolytic enzymes in a variety of industrial processes, the demand for a new effective producer has been constantly increasing. Furthermore, information on enzyme synthesis by autochthonous fungal strains is very seldom found. Two fungal strains producing ligninolytic enzymes were isolated from Bulgarian forest soil. They were identified as being Trametes trogii and T. hirsuta. These two strains were assessed for their enzyme activities, laccase (Lac), lignin peroxidase (LiP) and Mn‐dependent peroxidase (MnP) in culture filtrate depending on the temperature and the type of nutrient medium. T. trogii was selected as the better producer of ligninolytic enzymes. The production process was further improved by optimizing a number of parameters such as incubation time, type of cultivation, volume ratio of medium/air, inoculum size and the addition of inducers. The maximum activities of enzymes synthesized by T. trogii was detected as 11100 U/L for Lac, 2.5 U/L for LiP and 4.5 U/L for MnP after 14 days of incubation at 25°C under static conditions, volume ratio of medium/air 1:6, and 3 plugs as inoculum. Among the supplements tested, 5% glycerol increased Lac activity to a significant extent. The addition of 1% veratryl alcohol had a positive effect on MnP. [ABSTRACT FROM AUTHOR]

In the present investigation, we study catalytic activity of copper nanoparticles stabilized onto a nitro functionalized polystyrene resin (Cu NPs@ Nitro-Resin). The size of stabilized copper nanoparticles was found between 3 and 9 nm. This work reports a cost-effective and sustainable protocol for the synthesis of propargylamines. Herein, we have developed microwave-assisted synthesis of propargylamine from 3 components coupling of aldehyde, alkynes, and amines (A3 coupling) in truly heterogeneous catalytic system. Reaction parameters, such as solvent, catalyst concentration reaction time, and recyclability, were investigated, and reaction conditions were optimized. The present method has advantages such as environmentally benign, ease to handle, short reaction time (≈25 min), excellent yields (98%), low E-factor (0.15), and high atom economy (94%). [ABSTRACT FROM AUTHOR]

Purpose: Misinformation can have lasting impacts in the management and control of a public emergency. The purpose of this paper is to demonstrate how misinformation flows and how user characteristics can shape such flows in the context of a violent riot in Singapore. Design/methodology/approach: The authors apply the two-step flow theory and discuss the mixed methods approach involving wrangling Twitter data and descriptive analysis to develop and analyse two corpuses of misinformation related to the riot. Findings: The findings are mostly consistent with the two-step flow theory, in that misinformation flows to the masses from opinion leaders (as indicated by higher measures such as online social influence and followers/following ratio). In the presence of misinformation, tweets opposing such misinformation may not always come from opinion leaders. Practical implications: The authors work furthers knowledge about how misinformation goes viral, which provides practical implications to help policymakers and scholars in understanding and managing the dynamics and pitfalls of misinformation during an emergency. Originality/value: This paper tackles the problem of misinformation in public emergencies using a mixed methods approach and contributes to ongoing theoretical work on managing online misinformation especially in public emergencies and crises. [ABSTRACT FROM AUTHOR]

Onion storage is widely practised worldwide in accordance to their cultural and economical practice. In India, method of storage adopted mostly depends on the traditional knowledge and commonly practised methods are bag, pucca/room, tat storage, bamboo, chawl structure and the losses associated are quite higher. Sprouting, desiccation and microbial spoilage are often observed in storage and it compels to choose advanced techniques like modified ventilated structures, modified atmospheric (MA) and controlled atmospheric (CA) storage. The CA and MA storage reduces the application of chemicals for sprout inhibition by manipulating the gas composition to extend the storage period of the onions. [ABSTRACT FROM AUTHOR]

The symbiotic fungus Amylostereum areolatum is essential for growth and development of larvae of the invasive woodwasp, Sirex noctilio. In the nutrient poor xylem of pine trees, upon which Sirex feeds, it is unknown whether Amylostereum facilitates survival directly through consumption (mycetophagy) and/or indirectly through digestion of recalcitrant plant polymers (external rumen hypothesis). We tested these alternative hypotheses for Amylostereum involvement in Sirex foraging using the innate dependency of all insects on dietary sources of sterol and the unique sterols indicative of fungi and plants. We tested alternative hypotheses by using GC-MS to quantify concentrations of free and bound sterol pools from multiple life-stages of Sirex, food sources, and waste products in red pine ( Pinus resinosa). Cholesterol was the primary sterol found in all life-stages of Sirex. However, cholesterol was not found in significant quantities in either plant or fungal resources. Ergosterol was the most prevalent sterol in Amylostereum but was not detectable in either wood or insect tissue (<0.001 μg/g). Phytosterols were ubiquitous in both pine xylem and Sirex. Therefore, dealkylation of phytosterols (sitosterol and campesterol) is the most likely pathway to meet dietary demand for cholesterol in Sirex. Ergosterol concentrations from fungal-infested wood demonstrated low fungal biomass, which suggests mycetophagy is not the primary source of sterol or bulk nutrition for Sirex. Our findings suggest there is a potentially greater importance for fungal enzymes, including the external digestion of recalcitrant plant polymers (e.g., lignin and cellulose), shaping this insect-fungal symbiosis. [ABSTRACT FROM AUTHOR]

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Background: Social media have revolutionized the way we access information. Twitter is the most popular microblogging website and has become a tool for plastic surgery journals to connect with the greater academic community and public. The purpose of this study was to objectively assess the use of Twitter by plastic surgery journals., Methods: Twelve plastic surgery journals were searched on Twitter. The following data were collected: age of Twitter profile, number of followers and tweets posted, and whether the journal's website had a link to Twitter or another social media website. All tweets were reviewed from May to July of 2017 inclusive, and the level of evidence of each original article posted in the tweets was recorded. Impact factor and Klout score (a social media influence score) were collected for all journals., Results: Six of 12 plastic journals had a Twitter profile. The most social media-influencing journal in plastic surgery was Plastic and Reconstructive Surgery. This was followed by the Aesthetic Surgery Journal and the Journal of Hand Surgery (American and European Volumes). The presence of a Twitter profile was not associated with a higher impact factor for the journal. The Klout score was correlated with impact factor. Since joining Twitter, five of the six journals with Twitter profiles experienced increases in their impact factor., Conclusion: Twitter can be a quick and easy-to-use tool to increase exposure to evidence-based information from academic journals in plastic surgery.

The effect of recalcitrant soil and water pollutant 2,4,6-trinitrotoluen (TNT) on gene expression in Arabidopsis thaliana rosettes and roots was studied separately for the first time using microarrays. Seven-day exposure to TNT resulted in 170 up- and 122 down-regulated genes in the rosettes and 61 up- and 51 down-regulated genes in the roots (expression difference > 1.5-fold; p[ t test] < 0.05). TNT concentration, 5 µg/ml, was selected according to the dose response analysis and study of TNT uptake from liquid media. Although many TNT induced genes fell into ontology groups annotated as response to biotic and abiotic stresses in rosettes and roots, only a small overlap of TNT effects on transcriptome was observed between rosettes and roots. The rosettes exhibited induction of several genes associated with toxin metabolism, such as UDP-glycosyltransferases and ATP-binding cassette (ABC) family transporters. On the other side, no genes known to be involved in TNT transformation were found to be up-regulated in the roots. The genes coding for enzymes involved in the cell wall modifications were abundantly up-regulated in roots. Microarray data indicated that after a relatively long incubation with TNT (7 days), metabolism of this xenobiotic proceeded mainly in aerial parts, while its translocation into cell walls still took place in the roots. Results obtained by microarray hybridization were validated by quantitative real-time reverse-transcription PCR. Nitrate reductase 1, several glycosyltransferases and ABC transporters, sucrose-proton symporter 2, thioredoxin-dependent peroxidase 2, and gamma-glutamyltransferase are discussed for their potential to enhance detoxification and toleration capability of plants to TNT. [ABSTRACT FROM AUTHOR]