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In the past decade, there has been a surge in interest in space exploration studies, particularly due to the prospect of exploring distant planets such as Mars. However, long-duration space missions may pose cognitive challenges resulting from spaceflight-induced perceptual and motor changes, prolonged cephalic fluid shifts, and high cognitive load. One method for monitoring cognitive activity is functional near-infrared spectroscopy (fNIRS), a technique not yet tested under prolonged microgravity conditions beyond parabolic flight periods. Since fNIRS relies on cerebral oxygenation levels, should we adjust it for the fluid shift? To address this, the study explores the impact of simulated microgravity on cerebral oxygenation measures using fNIRS during a cognitive task, employing head-down tilt at different inclination levels and the Toulouse N-back Task (assessing memory and mental calculation) with varying difficulty levels. Eighteen subjects participated in the experiment. The results indicated that increasing difficulty levels of the cognitive task led to decreased accuracy, longer response times, and higher perceived difficulty scores. The inclination levels did not affect task performance. Increased difficulty was also concomitant with increasing HbO and decreasing HbR concentrations unaffected by the head-down tilt angle variations. These promising findings suggest that fNIRS measures could be used under microgravity conditions to measure cognitive load without correction for fluid shift. [ABSTRACT FROM AUTHOR]

Multidrug antimicrobial resistance (AMR) represents a formidable challenge in the therapy of infectious diseases, triggered by the particularly concerning gram-negative Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter spp. (ESKAPE) pathogens. Designated as a "priority" in 2017, these bacteria continue to pose a significant threat in 2024, particularly during the worldwide SARS-CoV-2 pandemic, where coinfections with ESKAPE members contributed to worsened patient outcomes. The declining effectiveness of current treatments against these pathogens has led to an increased disease burden and an increase in mortality rates globally. This review explores the sophisticated mechanisms driving AMR in gram-negative ESKAPE bacteria, focusing on Acinetobacter baumannii, Klebsiella pneumoniae, Pseudomonas aeruginosa, and Enterobacter spp. Key bacterial mechanisms contributing to resistance include limitations in drug uptake, production of antibiotic-degrading enzymes, alterations in drug target sites, and enhanced drug efflux systems. Comprehending these pathways is vital for formulating innovative therapeutic strategies and tackling the ongoing threat posed by these resistant pathogens. [ABSTRACT FROM AUTHOR]

Background: The Sensory Organization Test condition 5 (SOT5) assesses an astronaut's vestibular function pre-/post-spaceflight but has a ceiling effect and mainly evaluates standing balance, neglecting the challenges of walking during space missions. A Locomotor Sensory Organization Test (LSOT) has been developed, mirroring the SOT concept but tailored to assess vestibular function during walking. This study aims to advance current knowledge by examining changes in ground reaction force (GRF) during normal walking (LSOT1) and walking in LSOT5 (vision blocked and treadmill speed varied), both with and without mastoid vibrations. Methods: Sixty healthy adults were recruited and divided into two groups: one with mastoid vibration and one without. GRF peaks and respective variabilities were analyzed in the vertical (V), anterior-posterior (AP), and medial-lateral (ML) directions during stance cycles. The effects of LSOTs and mastoid vibration on each dependent variable were assessed using Friedman's two-way analysis of variance by ranks. Results: The findings revealed that:1) Walking in LSOT5 increased the variabilities of GRFs regardless of the administration of mastoid vibration; 2) the application of mastoid vibration reduced the amplitude of GRF peaks; and 3) walking in LSOT5 while receiving mastoid vibration was the most challenging task compared to all other tasks in this study. Conclusion: The results indicated that analyzing GRF can detect changes in the strategy of balance control across different sensory-conflicted conditions. The findings could be beneficial for assessing the vestibular function pre- and post-space missions and planning for future sensorimotor training programs aimed at enhancing astronauts' abilities to navigate unpredictable sensory-conflicted conditions. [ABSTRACT FROM AUTHOR]

Introduction: Current and future astronauts will endure prolonged exposure to spaceflight hazards and environmental stressors that could compromise cognitive functioning, yet cognitive performance in current missions to the International Space Station remains critically under-characterized. We systematically assessed cognitive performance across 10 cognitive domains in astronauts on 6-month missions to the ISS. Methods: Twenty-five professional astronauts were administered the Cognition Battery as part of National Aeronautics and Space Administration (NASA) Human Research Program Standard Measures Cross-Cutting Project. Cognitive performance data were collected at five mission phases: pre-flight, early flight, late flight, early post-flight, and late post-flight. We calculated speed and accuracy scores, corrected for practice effects, and derived z-scores to represent deviations in cognitive performance across mission phases from the sample's mean baseline (i.e., pre-flight) performance. Linear mixed models with random subject intercepts and pairwise comparisons examined the relationships between mission phase and cognitive performance. Results: Cognitive performance was generally stable over time with some differences observed across mission phases for specific subtests. There was slowed performance observed in early flight on tasks of processing speed, visual working memory, and sustained attention. We observed a decrease in risk-taking propensity during late flight and post-flight mission phases. Beyond examining group differences, we inspected scores that represented a significant shift from the sample's mean baseline score, revealing that 11.8% of all flight and post-flight scores were at or below 1.5 standard deviations below the sample's baseline mean. Finally, exploratory analyses yielded no clear pattern of associations between cognitive performance and either sleep or ratings of alertness. Conclusion: There was no evidence for a systematic decline in cognitive performance for astronauts on a 6-month missions to the ISS. Some differences were observed for specific subtests at specific mission phases, suggesting that processing speed, visual working memory, sustained attention, and risk-taking propensity may be the cognitive domains most susceptible to change in Low Earth Orbit for high performing, professional astronauts. We provide descriptive statistics of pre-flight cognitive performance from 25 astronauts, the largest published preliminary normative database of its kind to date, to help identify significant performance decrements in future samples. [ABSTRACT FROM AUTHOR]

Marine biomass is a sustainable source of valuable products, with the highly sulfated polysaccharide carrageenan being of particular interest to various industries. Novel carrageenans with modified sulfation patterns and carrageenan-based molecules hold promising potential in food, cosmetics, and biotechnology. Here, we describe the identification and application of novel sulfatases to tailor and break down this class of polysaccharides, enabling the manufacture of value-added products. [ABSTRACT FROM AUTHOR]

This work discusses the challenges of space exploration, focusing on microgravityinduced physiological changes, particularly those affecting the vestibular system, which significantly alters human performance in space, necessitating effective countermeasures. In microgravity, astronauts experience disorientation and space motion sickness due to changes in vestibular input, leading to symptoms like vertigo and headache. Postflight, astronauts show various neurological changes, similar to symptoms in individuals with vestibular disorders experiencing significant cognitive and perceptual difficulties. Studies have also shown that microgravity affects cortical and sensory responses, altering perception, motor function, and brain connectivity. Galvanic Vestibular Stimulation (GVS) is explored as a countermeasure, using modulated electrical currents to evoke neuronal activity in vestibular end-organs, potentially stabilizing posture and gaze in microgravity. The work proposes that GVS could serve as a non-invasive intervention to help adapt to space environments by enhancing vestibular function and possibly aiding cognitive functions and underscores the need for continued research into the vestibular system's role in human health and performance during space missions. It highlights the potential of GVS as a promising countermeasure for the challenges posed by microgravity. [ABSTRACT FROM AUTHOR]

Objectives: Mindfulness may be a helpful tool to enhance psychotherapists' self‐care and intrapersonal skills. To gain deeper knowledge about how to improve mindfulness skills in child and adolescent psychotherapists, we investigated the impact of two mindfulness‐based workshops and a self‐experience interval (individual homework practice of mindfulness exercises) on quantitative and qualitative measures in a nonrandomised study. Methods: Thirty‐six trainee psychotherapists took part in the 6‐week workshop‐based mindfulness intervention (experimental group, EG). Twenty‐one trainee psychotherapists served as a comparison group (CG). All participants completed the Kentucky Inventory of Mindfulness Skills (KIMS‐D), the Self‐Compassion Scale (SCS‐D) and the Empathy Scale for Social Workers (ESSW) at pre, post and 6‐month follow‐up. Benefits of the regular use of mindfulness practice of 10 trainee psychotherapists in the EG were analysed using qualitative content analysis at the 6‐month follow‐up. Results: The quantitative analyses revealed a significant increase over time on the KIMS‐D subscale "acting with awareness" in both groups and a significant increase over time on the KIMS‐D subscale "accepting without judgment" in the EG in contrast to the CG. The qualitative analyses indicated good acceptance of the mindfulness‐based workshop intervention. Qualitative changes referred to the achievement of knowledge in theory and practice concerning mindfulness and the integration of mindfulness‐based interventions in everyday life. Conclusion: The mindfulness intervention appeared to produce quantitative long‐term changes concerning mindfulness aspects and qualitative changes. Future research should elaborate conditions (i.e., intervention length, intensity and setting) that may influence the manifestation of quantitative and/or qualitative changes in mindfulness‐based workshop interventions in professionals. [ABSTRACT FROM AUTHOR]

Objectives: A growing body of research has already demonstrated the link between self-compassion and improved affective well-being and mental health. Initial findings have indicated that effective stress processing might be a mechanism underlying the beneficial effects of self-compassion on mental health outcomes. However, studies are still quite limited as they have mostly been cross-sectional and often included specific samples only. Thus, this research examines perceived stress and coping as two key mechanisms underlying the relation between self-compassion and affective well-being longitudinally in two different samples. Method: In two longitudinal studies with three measurement waves each, we assessed self-compassion, perceived stress, engagement and disengagement coping, and affective well-being. Study 1 analyzed a student sample (n = 684) across 12 weeks. Study 2 followed a population-based sample (n = 2934) across a 4-month period. Results: Cross-lagged panel analyses indicated that perceived stress mediated the link between self-compassion and affective well-being in both longitudinal studies. Engagement coping responses mediated this link in Study 2. Disengagement coping responses did not act as mediators in both studies. Conclusions: Our work helps to better understand the processes underlying the link between self-compassion and well-being. Self-compassion might facilitate effective stress responses in terms of less perceived stress and more salutary coping responses, which in turn might help to enhance affective well-being. Preregistration: All hypotheses were preregistered (as well as design, and analyses for the second Study) online at the Open Science Framework before starting with data collection (see preregistration at: https://osf.io/fhm9q/?view_only=577dd62d2f5548d59ccf703ee1d0d0a6). [ABSTRACT FROM AUTHOR]

Background: Anatomical differences between sexes in the vestibular system have been reported. It has also been demonstrated that there is a sex difference in balance control while standing on vestibular-demanding tasks. In 2024, NASA expects to send the first female to the Moon. Therefore, to extend the current knowledge, this study attempted to examine whether different sexes respond differently to vestibular-disrupted and vestibular-demanding environments. Method: A total of fifteen males and fifteen females participated in this study. The vestibular function was quantified through different SOT conditions (SOT1: baseline; SOT5: vestibular demanding by standing with blindfolded and sway reference surface). The vestibular stimulation (VS) was applied either unilaterally or bilaterally to vestibular system to induce the sensory-conflicted and challenging tasks. Thus, a total of 6 conditions (2 SOT conditions X 3 VSs: no-VS, unilateral VS, and bilateral VS) were randomly given to these participants. Three approaches can be quantified the balance control: 1) the performance ratio (PR) of center of gravity trajectories (CoG), 2) the sample entropy measure (SampEn) of CoG, and 3) the total traveling distance of CoG. A mixed three-way repeated ANOVA measure was used to determine the interaction among the sex effect, the effect of SOT, and the effect of VS on balance control. Results: A significant sex effect on balance control was found in the PR of CoG in the anterior-posterior (AP) direction (p = 0.026) and in the SampEn of CoG in both AP and medial-lateral (ML) directions (p = 0.025, p < 0.001, respectively). Also, a significant interaction among the sex effect, the effect of SOT, and the effect of VS on balance control was observed in PR of CoG in the ML direction (p < 0.001), SampEn of CoG in the AP and ML directions (p = 0.002, p < 0.001, respectively), and a traveling distance in AP direction (p = 0.041). Conclusion: The findings in the present study clearly revealed the necessity to take sex effect into consideration while standing in vestibular-perturbed or/and vestibular demanding tasks. Also, the results in the present study could be a fundamental reference for future sensorimotor training. [ABSTRACT FROM AUTHOR]

Pseudomonas aeruginosa is a ubiquitous Gram-negative bacterium renowned for its resilience and adaptability across diverse environments, including clinical settings, where it emerges as a formidable pathogen. Notorious for causing nosocomial infections, P. aeruginosa presents a significant challenge due to its intrinsic and acquired resistance mechanisms. This comprehensive review aims to delve into the intricate resistance mechanisms employed by P. aeruginosa and to discern how these mechanisms can be inferred by analyzing sensitivity patterns displayed in antibiograms, emphasizing the complexities encountered in clinical management. Traditional monotherapies are increasingly overshadowed by the emergence of multidrug-resistant strains, necessitating a paradigm shift towards innovative combination therapies and the exploration of novel antibiotics. The review accentuates the critical role of accurate antibiogram interpretation in guiding judicious antibiotic use, optimizing therapeutic outcomes, and mitigating the propagation of antibiotic resistance. Misinterpretations, it cautions, can inadvertently foster resistance, jeopardizing patient health and amplifying global antibiotic resistance challenges. This paper advocates for enhanced clinician proficiency in interpreting antibiograms, facilitating informed and strategic antibiotic deployment, thereby improving patient prognosis and contributing to global antibiotic stewardship efforts. [ABSTRACT FROM AUTHOR]

This review includes current and updated information about various ground-based microgravity models and their impact on the human sensorimotor system. All known models of microgravity are imperfect in a simulation of the physiological effects of microgravity but have their advantages and disadvantages. This review points out that understanding the role of gravity in motion control requires consideration of data from different environments and in various contexts. The compiled information can be helpful to researchers to effectively plan experiments using ground-based models of the effects of space flight, depending on the problem posed. [ABSTRACT FROM AUTHOR]

This article explores the effects of space travel on astronauts' brains. The researchers conducted a study on 15 astronauts, measuring their movement abilities and collecting brain images before and after their space missions. They discovered that astronauts faced challenges with movement, such as walking and balancing, upon returning to Earth. Furthermore, space travel caused alterations in the structure and function of their brains. The researchers aim to gain a deeper understanding of these effects to ensure the well-being of astronauts during long missions, like those to Mars. Alternative methods, such as bed rest experiments, studying individuals in Antarctica, and simulating weightlessness, have been used to study the effects of space travel on the human body. While these studies provide valuable insights, studying actual astronauts remains crucial. Research on astronauts' brains has revealed temporary changes in brain structure and function after space travel, which typically return to normal within a few months. Ongoing research on astronauts will enhance our understanding of the impacts of space travel and contribute to the development of improved training and treatments for future missions. [Extracted from the article]

Transitioning between gravitational environments results in a central reinterpretation of sensory information, producing an adapted sensorimotor state suitable for motor actions and perceptions in the new environment. Critically, this central adaptation is not instantaneous, and complete adaptation may require weeks of prolonged exposure to novel environments. To mitigate risks associated with the lagging time course of adaptation (e.g., spatial orientation misperceptions, alterations in locomotor and postural control, and motion sickness), it is critical that we better understand sensorimotor states during adaptation. Recently, efforts have emerged to model human perception of orientation and self-motion during sensorimotor adaptation to new gravity stimuli. While these nascent computational frameworks are well suited for modeling exposure to novel gravitational stimuli, they have yet to distinguish how the central nervous system (CNS) reinterprets sensory information from familiar environmental stimuli (i.e., readaptation). Here, we present a theoretical framework and resulting computational model of vestibular adaptation to gravity transitions which captures the role of implicit memory. This advancement enables faster readaptation to familiar gravitational stimuli, which has been observed in repeat flyers, by considering vestibular signals dependent on the new gravity environment, through Bayesian inference. The evolution and weighting of hypotheses considered by the CNS is modeled via a Rao-Blackwellized particle filter algorithm. Sensorimotor adaptation learning is facilitated by retaining a memory of past harmonious states, represented by a conditional state transition probability density function, which allows the model to consider previously experienced gravity levels (while also dynamically learning new states) when formulating new alternative hypotheses of gravity. In order to demonstrate our theoretical framework and motivate future experiments, we perform a variety of simulations. These simulations demonstrate the effectiveness of this model and its potential to advance our understanding of transitory states during which central reinterpretation occurs, ultimately mitigating the risks associated with the lagging time course of adaptation to gravitational environments. [ABSTRACT FROM AUTHOR]

The deep space environment far beyond low-Earth orbit (LEO) introduces multiple and simultaneous risks for the functioning and health of the central nervous system (CNS), which may impair astronauts’ performance and wellbeing. As future deep space missions to Mars, moons, or asteroids will also exceed current LEO stay durations and are estimated to require up to 3 years, we review recent evidence with contemporary and historic spaceflight case studies addressing implications for longduration missions. To highlight the need for specific further investigations, we provide neuropsychological considerations integrating cognitive and motor functions, neuroimaging, neurological biomarkers, behavior changes, and mood and affect to construct a multifactorial profile to explain performance variability, subjective experience, and potential risks. We discuss the importance of adopting a neuropsychological approach to long-duration deep spaceflight (LDDS) missions and draw specific recommendations for future research in space neuropsychology. [ABSTRACT FROM AUTHOR]

As humanity prepares for deep space exploration, understanding the impact of spaceflight on bodily physiology is critical. While the effects of non-terrestrial gravity on the body are well established, little is known about its impact on human behaviour and cognition. Astronauts often describe dramatic alterations in sensorimotor functioning, including orientation, postural control, and balance. Changes in cognitive functioning as well as in socio-affective processing have also been observed. Strikingly, no comprehensive theoretical model exists to outline the impact of non-terrestrial gravity on behaviour. Here, we have reviewed the key literature across the last 10 years and explored the impact of non-terrestrial gravity across three key functional domains: sensorimotor functioning, cognition, and socio-affective processing. We have proposed and preliminary validated a neurocognitive model to account for the effects of non-terrestrial gravity in these domains. Understanding the impact of non-terrestrial gravity on human behaviour has never been timelier and it will help mitigate against risks in both commercial and non-commercial spaceflight. [ABSTRACT FROM AUTHOR]

Self-compassion, which refers to being kind and understanding toward oneself when suffering or experiencing personal inadequacies, is widely seen as a protective factor against mental health problems in adolescents and adults. To date, most research is conducted on adults using the Self-Compassion Scale (SCS), although adolescence is seen as a challenging period in life. Self-compassion research has only recently started to focus on childhood and adolescence. We aimed to translate the English version of the SCS for adolescents into German, test its psychometric properties, and examine potential gender differences more closely. We used confirmatory factor analysis (CFA) to find the best-fitting model out of a two, three, and six-factorial solution. The sample consisted of 255 adolescents, 10 to 19 years old, from a community sample. The study was designed as an online survey. We found the six-factorial solution to best fit our data. Males were significantly more self-compassionate than females. The Self-Compassion Scale – Children and Adolescents (SCS-CA) and its subscales showed good internal consistency as well as good content, criterion, and construct validity with measures of mindfulness, quality of life, and psychopathology. We discuss implications of these findings for a better understanding of adolescent well-being and mental health, as well as potential benefits of a future application of this measure. Overall, our findings suggest that the developed questionnaire is an economical, valid, and reliable measure to assess self-compassion in German adolescents. Trial registration: From ClinicalTrials.gov, Identifier: NCT04034576 (registered 07/17/19). Highlights: Translation and validation of the SCS for adolescents from English to German with 10- to 19-year-olds from a community sample. CFA indicates that a six-factorial solution for SCS-CA in adolescents best fits the data. Good psychometric properties and replication of the link of self-compassion, mindfulness, and psychopathology. Male adolescents were significantly more self-compassionate than females. One step in better understanding adolescent well-being, mental health, and potential resilience factors. [ABSTRACT FROM AUTHOR]

Multidrug-resistant Gram-negative bacteria such as Acinetobacter baumannii, Pseudomonas aeruginosa, and members of the Enterobacterales order are a challenging multi-sectorial and global threat, being listed by the WHO in the priority list of pathogens requiring the urgent discovery and development of therapeutic strategies. We present here an overview of the antibiotic resistance profiles and epidemiology of Gram-negative pathogens listed in the ESCAPE group circulating in Romania. The review starts with a discussion of the mechanisms and clinical significance of Gram-negative bacteria, the most frequent genetic determinants of resistance, and then summarizes and discusses the epidemiological studies reported for A. baumannii, P. aeruginosa, and Enterobacterales-resistant strains circulating in Romania, both in hospital and veterinary settings and mirrored in the aquatic environment. The Romanian landscape of Gram-negative pathogens included in the ESCAPE list reveals that all significant, clinically relevant, globally spread antibiotic resistance genes and carrying platforms are well established in different geographical areas of Romania and have already been disseminated beyond clinical settings. [ABSTRACT FROM AUTHOR]

We report a study on astronauts aimed at characterizing duration judgment before, during, and after long-duration stays on board the International Space Station. Ten astronauts and a control group of 15 healthy (non-astronaut) participants performed a duration reproduction task and a duration production task using a visual target duration ranging from 2 to 38 s. Participants also performed a reaction time test for assessing attention. Compared to control participants and preflight responses, the astronauts' reaction time increased during spaceflight. Also, during spaceflight, time intervals were underproduced while counting aloud and under-reproduced when there was a concurrent reading task. We hypothesize that time perception during spaceflight is altered by two mechanisms: (a) an acceleration of the internal clock through the changes in vestibular inputs in microgravity, and (b) difficulties in attention and working memory when a concurrent reading task is present. Prolonged isolation in confined areas, weightlessness, stress related to workload, and high-performance expectations could account for these cognitive impairments. [ABSTRACT FROM AUTHOR]

Although a number of studies have examined cognitive functions in space, the reasons behind the observed changes described by space research and anecdotal reports have not yet been elucidated. A potential source of cognitive changes is the cephalad fluid shift in the body caused by the lack of hydrostatic pressure under microgravity. These alterations can be modeled under terrestrial conditions using ground-based studies, such as head-down tilt bedrest (HDBR). In this review, we compare the results of the space and HDBR cognitive research. Results for baseline and in-flight/in-HDBR comparisons, and for baseline and post-flight/post-HDBR comparisons are detailed regarding sensorimotor skills, time estimation, attention, psychomotor speed, memory, executive functions, reasoning, mathematical processing, and cognitive processing of emotional stimuli. Beyond behavioral performance, results regarding brain electrical activity during simulated and real microgravity environments are also discussed. Finally, we highlight the research gaps and suggest future directions. [ABSTRACT FROM AUTHOR]

Objectives: While the positive effects of trait self-compassion on affective well-being are widely known, within-person effects of state self-compassion and underlying mechanisms between state self-compassion and affective well-being have rarely been investigated. The current study aimed at examining whether perceived stress and healthier coping responses are mediators in the relation between momentary self-compassion and affective well-being. Methods: A total of 213 participants completed measures of momentary self-compassion, momentary perceived stress, and engagement and disengagement coping responses, as well as affective well-being (i.e., presence of positive and absence of negative affect) via their smartphones. The ambulatory assessment design included three measurements per day (morning, afternoon, evening) for 7 days. Results: Multilevel modeling revealed that within-persons, momentary levels of self-compassion were related to momentary levels of stress, coping responses, and affective well-being components. 1–1-1 multilevel mediation analyses were conducted and demonstrated that, at the within-person level, momentary self-compassion was related to more positive and less negative affect via perceived stress and facilitating healthy coping responses. The within-person relations of the original 1–1-1 multilevel mediation could partially be replicated in an alternative model with momentary self-compassion one occasion prior and positive affect. However, the link between self-compassion one occasion prior and negative affect was only mediated by perceived stress. Conclusions: This work helps to understand the processes underlying the adaptive effects of momentary self-compassion on momentary affective well-being on a given occasion. Theoretical and practical implications of these findings are discussed. [ABSTRACT FROM AUTHOR]

The altered vestibular signaling and somatosensory unloading of microgravity result in sensory reweighting and adaptation to conflicting sensory inputs. Aftereffects of these adaptive changes are evident postflight as impairments in behaviors such as balance and gait. Microgravity also induces fluid shifts toward the head and an upward shift of the brain within the skull; these changes are well-replicated in strict head-down tilt bed rest (HDBR), a spaceflight analog environment. Artificial gravity (AG) is a potential countermeasure to mitigate these effects of microgravity. A previous study demonstrated that intermittent (six, 5-mins bouts per day) daily AG sessions were more efficacious at counteracting orthostatic intolerance in a 5 day HDBR study than continuous daily AG. Here we examined whether intermittent daily AG was also more effective than continuous dosing for mitigating brain and behavioral changes in response to 60 days of HDBR. Participants (n = 24) were split evenly between three groups. The first received 30 mins of continuous AG daily (cAG). The second received 30 mins of intermittent AG daily (6 bouts of 5 mins; iAG). The third received no AG (Ctrl). We collected a broad range of sensorimotor, cognitive, and brain structural and functional assessments before, during, and after the 60 days of HDBR. We observed no significant differences between the three groups in terms of HDBR-associated changes in cognition, balance, and functional mobility. Interestingly, the intermittent AG group reported less severe motion sickness symptoms than the continuous group during centrifugation; iAG motion sickness levels were not elevated above those of controls who did not undergo AG. They also had a shorter duration of post-AG illusory motion than cAG. Moreover, the two AG groups performed the paced auditory serial addition test weekly while undergoing AG; their performance was more accurate than that of controls, who performed the test while in HDBR. Although AG did not counteract HDBR-induced gait and balance declines, iAG did not cause motion sickness and was associated with better self-motion perception during AG ramp-down. Additionally, both AG groups had superior cognitive performance while undergoing AG relative to controls; this may reflect attention or motivation differences between the groups. [ABSTRACT FROM AUTHOR]

We demonstrate a probe of long-range antiferromagnetic (AF) order in FeRh thin films using non-resonant magnetic x-ray scattering. In particular, x-rays at energies below the Fe K-edge have been used for the observation of magnetic Bragg peaks. Due to the low efficiency of the magnetic scattering, a grazing incidence geometry was used to optimise the diffracted intensity from the thin film samples. Based on Scherrer analysis, we estimate a coherence length similar to previous reports from x-ray magnetic linear dichroism (XMLD) experiments, indicating that domain sizes are limited to 40 nm which is consistent with the grain size. The temperature dependent behaviour of the AF order shows an inverse correlation with the emergence of the ferromagnetic (FM) moment, as expected from the phase diagram. [ABSTRACT FROM AUTHOR]

Structural and calorimetric investigation of GexTe100-x films over wide range of concentration 10 < x < 50 led to evidence two structural singularities at x ~ 22 at. % and x ~ 33-35 at. %. Analysis of bond distribution, bond variability, and glass thermal stability led to conclude to the origin of the first singularity being the flexible/rigid transition proposed in the framework of rigidity model and the origin of the second one being the disappearance of the undercooled region resulting in amorphous materials with statistical distributions of bonds. While the first singularity signs the onset of the Ge-Ge homopolar bonds, the second is related to compositions where enhanced Ge-Ge correlations at intermediate lengthscales (7.7 Å) are observed. These two threshold compositions correspond to recently reported resistance drift threshold compositions, an important support for models pointing the breaking of homopolar Ge-Ge bonds as the main phenomenon behind the ageing of phase change materials. [ABSTRACT FROM AUTHOR]

Astronauts returning from spaceflight typically show transient declines in mobility and balance. Other sensorimotor behaviors and cognitive function have not been investigated as much. Here, we tested whether spaceflight affects performance on various sensorimotor and cognitive tasks during and after missions to the International Space Station (ISS). We obtained mobility (Functional Mobility Test), balance (Sensory Organization Test-5), bimanual coordination (bimanual Purdue Pegboard), cognitive-motor dual-tasking and various other cognitive measures (Digit Symbol Substitution Test, Cube Rotation, Card Rotation, Rod and Frame Test) before, during and after 15 astronauts completed 6 month missions aboard the ISS. We used linear mixed effect models to analyze performance changes due to entering the microgravity environment, behavioral adaptations aboard the ISS and subsequent recovery from microgravity. We observed declines in mobility and balance from pre- to post-flight, suggesting disruption and/or down weighting of vestibular inputs; these behaviors recovered to baseline levels within 30 days post-flight. We also identified bimanual coordination declines from pre- to post-flight and recovery to baseline levels within 30 days post-flight. There were no changes in dual-task performance during or following spaceflight. Cube rotation response time significantly improved from pre- to post-flight, suggestive of practice effects. There was also a trend for better in-flight cube rotation performance on the ISS when crewmembers had their feet in foot loops on the "floor" throughout the task. This suggests that tactile inputs to the foot sole aided orientation. Overall, these results suggest that sensory reweighting due to the microgravity environment of spaceflight affected sensorimotor performance, while cognitive performance was maintained. A shift from exocentric (gravity) spatial references on Earth toward an egocentric spatial reference may also occur aboard the ISS. Upon return to Earth, microgravity adaptions become maladaptive for certain postural tasks, resulting in transient sensorimotor performance declines that recover within 30 days. [ABSTRACT FROM AUTHOR]

Multiple transition phenomena in divalent Eu compound EuAl4 with the tetragonal structure were investigated via the single-crystal time-of-flight neutron Laue technique. At 30.0 K below a charge-density-wave (CDW) transition temperature of TCDW = 140 K, superlattice peaks emerge near nuclear Bragg peaks described by an ordering vector \(\boldsymbol{q}_{\text{CDW}} = (0,0,\delta _{c})\) with δc ∼ 0.19. In contrast, magnetic peaks appear at \(\boldsymbol{q}_{2} = (\delta _{2},\delta _{2},0)\) with δ2 = 0.085 in a magnetic-ordered phase at 13.5 K below TN1 = 15.4 K. By further cooling to below TN3 = 12.2 K, the magnetic ordering vector changes into \(\boldsymbol{q}_{1} = (\delta _{1},0,0)\) with δ1 = 0.17 at 11.5 K and slightly shifts to δ1 = 0.194 at 4.3 K. No distinct change in the magnetic Bragg peak was detected at TN2 = 13.2 K and TN4 = 10.0 K. The structural modulation below TCDW with qCDW is characterized by the absence of the superlattice peak in the (0 0 l) axis. As a similar CDW transition was observed in SrAl4, the structural modulation with qCDW could be mainly ascribed to the displacement of Al ions within the tetragonal ab-plane. Complex magnetic transitions are in stark contrast to a simple collinear magnetic structure in isovalent EuGa4. This could stem from different electronic structures with the CDW transition between two compounds. [ABSTRACT FROM AUTHOR]

Despite significant biological, psychological, and social challenges in the perimenopause, most women report an overall positive well-being and appear to be resilient to potentially negative effects of this life phase. The objective of this study was to detect psychosocial variables which contribute to resilience in a sample of perimenopausal women. A total of 135 healthy perimenopausal women aged 40–56 years completed a battery of validated psychosocial questionnaires including variables related to resilience, well-being, and mental health. First, using exploratory factor analysis, we examined which of the assessed variables related to resilience can be assigned to a common factor. Second, linear regression analyses were performed to investigate whether a common resilience factor predicts well-being and mental health in the examined sample of women. Optimism (LOT-R-O), emotional stability (BFI-K-N), emotion regulation (ERQ), self-compassion (SCS-D), and self-esteem (RSES) in perimenopausal women can be allocated to a single resilience-associated factor. Regression analyses revealed that this factor is related to higher life satisfaction (SWLS; β =.39, p <.001, adj. R2 =.20), lower perceived stress (PSS-10; β = −.55, p <.001, adj. R2 =.30), lower psychological distress (BSI-18; β = −.49, p <.001, adj. R2 =.22), better general psychological health (GHQ-12; β = −.49, p <.001, adj. R2 =.22), milder menopausal complaints (MRS II; β = −.41, p <.001, adj. R2 =.18), and lower depressive symptoms (ADS-L; β = −.32, p <.001, adj. R2 =.26). The α levels were adjusted for multiple testing. Our findings confirm that several psychosocial variables (optimism, emotional stability, emotion regulation, self-compassion, and self-esteem) can be allocated to one common resilience-associated factor. This resilience factor is strongly related to women's well-being as well as mental health in perimenopause. [ABSTRACT FROM AUTHOR]

Self-compassion is associated with disability, pain-related anxiety as well as depression and anger in patients with chronic pain. However, the unique value of self-compassion versus other concepts such as psychological flexibility and self-esteem is unknown. The present study therefore aimed to clarify these relationships. Individuals with chronic pain (NCP = 872) and without chronic pain (NNP = 356) took part in a longitudinal study. Participants completed self-report instruments: Pain Disability Index (PDI), Pain Catastrophizing Scale (PCS), Pain Anxiety Symptom Scale (PASS-20), Patient Health Questionnaire (PHQ-9), State Trait Anger Expression Inventory (STAXI), Self-Compassion Scale (SCS), Psychological Inflexibility in Pain Scale (PIPS) and Rosenberg Self-Esteem Scale (RSES). Assessments were repeated after 8 weeks. We found differences in baseline levels of all relevant variables except for anger-out and anger-control between people with and without chronic pain. Subsequently, we computed a path model analysis regarding individuals suffering from chronic pain (NCP), addressing the predictive value of reduced uncompassionate self-responding (RUS), compassionate self-responding (CS), avoidance (PIPS), cognitive fusion (PIPS) and self-esteem (RSES) regarding pain-related (PDI, PCS, PASS) and emotional variables (PHQ-9, STAXI). Avoidance predicted disability, catastrophizing, anxiety and depression. RUS predicted catastrophizing and pain-related anxiety. Self-esteem predicted depression. CS and cognitive fusion had no unique predictive value. The model explained 65.4%-72.1% of the variance in pain-related variables, 68.7% of the variance in depression and 38.7%-60.7% in the variance of anger-related variables. In conclusion, psychological flexibility, in terms of avoidance, seems to be more relevant for chronic pain than self-compassion. Future research should focus on subgroups and tailored-treatment approaches. SIGNIFICANCE: Applying a longitudinal design, this study examined the predictive value of self-compassion regarding pain, depression and anger. The relevance of self-compassion was compared to psychological flexibility and self-esteem. We can conclude that psychological flexibility, in terms of avoidance behaviour, is the most relevant predictor concerning pain. [ABSTRACT FROM AUTHOR]