9,666 results on '"Corti M"'
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2. Reseña de Friedrich Christian Schroeder. El rayo como instrumento de asesinato. Sancinetti, Marcelo A. (trad.); Tuñón Corti, M. Lucila (rev.), Editorial Hammurabi
- Author
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Cruz Domínguez, Martín
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Derecho ,Imputación objetiva ,Ciencia jurídico penal - Abstract
Génesis y evolución de la teoría de la imputación objetiva: una travesía por 150 años de ciencia jurídico penal.
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- 2023
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3. Early sowing dates and pre-plant nitrogen affect autumn weed control and nitrogen content of winter cover crops in rotation with spring crops
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Corti, M., Bechini, L., Cavalli, D., Ben Hassine, M., Michelon, L., Cabassi, G., Pricca, N., Perego, A., and Marino Gallina, P.
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- 2024
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4. Modulation of liver fibrosis and pathophysiological changes in mice infected with Mesocestoides corti (M. vogae) after administration of glucan and liposomized glucan in combination with vitamin C
- Author
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Ditteová, G., Velebný, S., and Hrčkova, G.
- Published
- 2003
5. Physical characterization of S169: A prototypical IR bubble associated with the massive star-forming region IRAS12326-6245
- Author
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Duronea, N. U., Cichowolski, S., Bronfman, L., Mendoza, E., Finger, R., Suad, L. A., Corti, M., and Reynoso, E. M.
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Astrophysics - Astrophysics of Galaxies ,Astrophysics - Solar and Stellar Astrophysics - Abstract
With the aim of studying the properties of Galactic IR bubbles and their impact in massive star formation, we present a study of the IR bubble S169, associated with the massive star forming region IRAS12326-6245. We used CO(2-1),$^{13}$CO(2-1), C$^{18}$O(2-1), HCN(3-2), and HCO+(3-2) line data obtained with the APEX telescope to study the properties of the molecular gas in the nebula and the IRAS source . To analyze the properties and distribution of the dust, we used IRAC-GLIMPSE, Herschel, and ATLASGAL data. The properties of the ionized gas were studied using images obtained from the SUMSS survey and SuperCOSMOS database. In our search for stellar and protostellar objects in the region, we used IR and optical point source calalogs. The new APEX observations allowed us to identify three molecular components associated with the nebula, namely: at $-$39 km/s (component A), $-$25 km/s (component B), and $-$17 km/s (component C). Six molecular condensations (MC1 to MC6) were identified in component A, with MC3 (the densest and more massive one) being the molecular counterpart of IRAS12326-6245. For this source, we estimated an H$_2$ column density up to 8$\times$10$^{23}$ cm$^{-2}$. To explain the morphology and velocity of components A, B, and C, we propose a simple model consisting of a partially complete semisphere-like structure expanding at ~ 12 km/s. The introduction of this model has led to a discussion about the distance to both S169 and IRAS12326-6245, which was estimated to be ~ 2 kpc. Several candidate YSOs were identified, projected mostly onto the molecular condensations MC3, MC4, and MC5, which indicates that the star-formation process is very active at the borders of the nebula. A comparison between observable and modeled parameters was not enough to discern whether the collect-and-collapse mechanism is acting at the edge of S169., Comment: 17 pages, 12 figures. Accepted for publication in A&A
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- 2020
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6. Boosting of the water-mediated mineral carbonation by microwave chemistry
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D’Alessio, D, Corti, M, Campione, M, Capitani, G, Lucotti, A, Yivlialin, R, Tommasini, M, Bussetti, G, Malaspina, N, D’Alessio D, Corti M, Campione M, Capitani G., Lucotti A, Yivlialin R, Tommasini M, Bussetti G, Malaspina N, D’Alessio, D, Corti, M, Campione, M, Capitani, G, Lucotti, A, Yivlialin, R, Tommasini, M, Bussetti, G, Malaspina, N, D’Alessio D, Corti M, Campione M, Capitani G., Lucotti A, Yivlialin R, Tommasini M, Bussetti G, and Malaspina N
- Published
- 2024
7. Experimental determination of the frequency and field dependence of Specific Loss Power in Magnetic Fluid Hyperthermia
- Author
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Cobianchi, M., Guerrini, A., Avolio, M., Innocenti, C., Corti, M., Arosio, P., Orsini, F., Sangregorio, C., and Lascialfari, A.
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Physics - Biological Physics ,Physics - Medical Physics - Abstract
Magnetic nanoparticles are promising systems for biomedical applications and in particular for Magnetic Fluid Hyperthermia, a promising therapy that utilizes the heat released by such systems to damage tumor cells. We present an experimental study of the physical properties that influences the capability of heat release, i.e. the Specific Loss Power, SLP, of three biocompatible ferrofluid samples having a magnetic core of maghemite with different core diameter d= 10.2, 14.6 and 19.7 nm. The SLP was measured as a function of frequency f and intensity of the applied alternating magnetic field H, and it turned out to depend on the core diameter, as expected. The results allowed us to highlight experimentally that the physical mechanism responsible for the heating is size-dependent and to establish, at applied constant frequency, the phenomenological functional relationship SLP=cH^x, with 2
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- 2017
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8. Swallowing Safety and Efficiency in Infants With Spinal Muscular Atrophy at the Time of Diagnosis
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Leon Astudillo, C., primary, Kanjani, P.O., additional, Brooks, O., additional, Kimes, A., additional, Salabarria, S.M., additional, Coker, M., additional, Berthy, J., additional, Corti, M., additional, Gurka, M., additional, Byrne, B.J., additional, and Smith, B.K., additional
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- 2024
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9. Pulsating low-mass white dwarfs in the frame of new evolutionary sequences: III. The pre-ELM white dwarf instability strip
- Author
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Córsico, A. H., Althaus, L. G., Serenelli, A. M., Kepler, S. O., Jeffery, C. S., and Corti, M. A.
- Subjects
Astrophysics - Solar and Stellar Astrophysics - Abstract
Two low-mass pre-white dwarfs, which could be precursors of ELM white dwarfs, have been observed to show multiperiodic photometric variations. They could constitute a new class of pulsating low-mass pre-white dwarf stars. We present a detailed nonadiabatic pulsation study of such stars, employing full evolutionary sequences of low-mass He-core pre-white dwarf models. We have considered models in which element diffusion is accounted for and also models in which it is neglected. We confirm and explore in detail a new instability strip in the domain of low gravities and low effective temperatures of the $T_{\rm eff}-\log g$ diagram, where low-mass pre-white dwarfs are currently found. The destabilized modes are radial and nonradial $p$ and $g$ modes excited by the $\kappa-\gamma$ mechanism acting mainly at the zone of the second partial ionization of He, with non-negligible contributions from the region of the first partial ionization of He and the partial ionization of H. The computations with element diffusion are unable to explain the pulsations observed in the two known pulsating pre-white dwarfs, suggesting that element diffusion might be inhibited at these stages of the pre-white dwarf evolution. Our nonadiabatic models without diffusion, on the other hand, naturally explain the existence and range of periods of the pulsating pre-white dwarf star WASP J1628$+$10B, although they fail to explain the pulsations of WASP J0247$-$25B, the other known member of the class, indicating that the He abundance in the driving region of this star might be substantially larger than predicted by our models. Further discoveries of additional members of this new class of pulsating stars and their analysis in the context of the theoretical background presented in this paper will shed new light on the evolutionary history of their progenitor stars., Comment: 15 pages, 15 figures, 1 table. To be published in Astronomy and Astrophysics
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- 2016
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10. Two new pulsating low-mass pre-white dwarfs or SX Phenix stars?*
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Corti, M. A., Kanaan, A., Córsico, A. H., Kepler, S. O., Althaus, L. G., Koester, D., and Arias, J. P. Sánchez
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Astrophysics - Solar and Stellar Astrophysics - Abstract
Context. The discovery of pulsations in low-mass stars opens an opportunity for probing their interiors and to determine their evolution, by employing the tools of asteroseismology. Aims. We aim to analyze high-speed photometry of SDSSJ145847.02$+$070754.46 and SDSSJ173001.94$+$070600.25 and discover brightness variabilities. In order to locate these stars in the $T_{\rm eff} - \log g$ diagram we fit optical spectra (SDSS) with synthetic non-magnetic spectra derived from model atmospheres. Methods. To carry out this study, we used the photometric data obtained by us for these stars with the 2.15m telescope at CASLEO, Argentina. We analyzed their light curves and we apply the Discrete Fourier Transform to determine the pulsation frequencies. Finally, we compare both stars in the $T_{\rm eff} - \log g$ diagram, with known two pre-white dwarfs, seven pulsating pre-ELM white dwarf stars, $\delta$ Scuti and SX Phe stars. Results. We report the discovery of pulsations in SDSSJ145847.02$+$070754.46 and SDSSJ173001.94$+$070600.25. We determine their effective temperature and surface gravity to be $T_{\rm eff}$ = 7 972 $\pm$ 200 K, $\log g$ = 4.25 $\pm$ 0.5 and $T_{\rm eff}$ = 7 925 $\pm$ 200 K, $\log g$ = 4.25 $\pm$ 0.5, respectively. With these parameters these new pulsating low-mass stars can be identified with either ELM white dwarfs (with ~ 0.17 Mo) or more massive SX Phe stars. We identified pulsation periods of 3 278.7 and 1 633.9 s for SDSSJ145847.02$+$070754.46 and a pulsation period of 3 367.1 s for SDSSJ173001.94$+$070600.25. These two new objects together with those of Maxted et al. (2013, 2014) indicate the possible existence of a new instability domain towards the late stages of evolution of low-mass white dwarf stars, although their identification with SX Phe stars cannot be discarded., Comment: 5 pages, 5 figures, 1 table, accepted for publication in A&AL
- Published
- 2016
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11. The embedded clusters DBS 77, 78, 102, and 160-161 and their link with the interstellar medium
- Author
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Corti, M. A., Baume, G. L., Panei, J. A., Suad, L. A., Testori, J. C., Borissova, J., Kurtev, R., Chené, A. N., and Alegría, S. Ramirez
- Subjects
Astrophysics - Solar and Stellar Astrophysics ,Astrophysics - Astrophysics of Galaxies - Abstract
Aims. We report a study of the global properties of some embedded clusters placed in the fourth quadrant of the Milky Way to clarify some issues related with their location into the Galaxy and their stellar formation processes. Methods. We performed BVI photometric observations in the region of DBS 77, 78, 102, 160, and 161 clusters and infrared spectroscopy in DBS 77 region. They were complemented with JHK data from VVV survey combined with 2MASS catalogue, and used mid-infrared information from GLIMPSE catalogue. We also searched for HI data from SGPS and PMN radio surveys, and previous spectroscopic stellar classification. The spectroscopic and photometric information allowed us to estimate the spectral classification of the brightest stars of each studied region. On the other hand, we used the radio data to investigate the interstellar material parameters and the continuum sources probably associated with the respective stellar components. Results. We estimated the basic physical parameters of the clusters (reddening, distance, age, and initial mass function). We searched for HII regions located near to the studied clusters and we analyzed the possible link between them. In the particular case of DBS 160-161 clusters, we identified the HI bubble B332.5-0.1-42 located around them. We found that the mechanical energy injected to the interstellar medium by the more massive stars of this couple of clusters was enough to generate the bubble., Comment: 15 pages, 14 figures, 6 tables, accepted for publication in A&A
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- 2016
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12. Forced air flow through a rectangular channel with 3D turbulence enhancers: visualization of flow structures by laser sheet scattering.
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Vitali, L, Corti, M, Gramazio, P, Fustinoni, D, and Niro, A
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- 2024
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13. Forced air flow through a rectangular channel with 3D turbulence enhancers: fluid-dynamics and thermal analysis by Large Eddy Simulations.
- Author
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Corti, M, Vitali, L, Gramazio, P, Fustinoni, D, and Niro, A
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- 2024
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14. Light Scattering in Liquids and Macromolecular Solutions. Proceedings of the Workshop on Quasi-elastic Light Scattering Studies of Fluids and Macromolecular Solutions, Milan, Italy, 1979 V. Degiorgio M. Corti M. Giglio
- Author
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Berry, Guy C.
- Published
- 1982
15. L’allevamento del bestiame in area alpina tra età moderna e contemporanea: nuovi contributi e piste di ricerca
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Besana, C, Corti, M, Mocarelli, L, Besana, C, Corti, M, and Mocarelli, L
- Published
- 2024
16. Transumanze. La mobilità dell’allevamento bovino in Lombardia e in altre regioni alpine (secc. XIV-XX)
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Besana Claudio, Corti Michele, Mocarelli Luca, Besana, C, Corti, M, Mocarelli, L, Besana Claudio, Corti Michele, Mocarelli Luca, Besana, C, Corti, M, and Mocarelli, L
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- 2024
17. I malghesi nelle aziende della pianura irrigua in età contemporanea
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Besana, C, Corti, M, Mocarelli, L, Fumi, Gianpiero, Gianpiero Fumi (ORCID:0000-0002-8107-3505), Besana, C, Corti, M, Mocarelli, L, Fumi, Gianpiero, and Gianpiero Fumi (ORCID:0000-0002-8107-3505)
- Abstract
Il sistema agricolo della bassa Lombardia si caratterizza storicamente per un elevato stock di bestiame per ragioni tecniche ed economiche. Per mantenere in efficienza le aziende della pianura si faceva frequente ricorso anche a bestiame stagionale proveniente dall'area alpina. Un fenomeno antico, che caratterizza l'agricoltura intensiva ancora in età contemporanea e porta all'incontro, nei lunghi mesi dell'autunno e dell'inverno, presso le aziende agricole di pianura di imprenditorialità e risorse diverse. I malghesi con le loro famiglie apportano bestiame vivo, competenze tecniche, attitudini produttive e capacità economiche. Il saggio analizza il tema avvalendosi anche di fonti inedite., The agricultural system of lower Lombardy is historically characterized by a large livestock, motivated by technical and economic reasons. To keep the farms of the Po plain efficient, frequent use was made of seasonal livestock from the Alpine area. A centuries-old phenomenon, which continued in the contemporary age until mid-20th century. It implied the convergence in the same farm, during autumn and winter, of different entrepreneurship and resources . In particular, the "malghesi" (transhumant breeders) with their families bring good livestock, technical skills, ability in cheese making, economic capacity. The essay analyzes the theme also using unpublished sources.
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- 2024
18. Microwave-driven carbonation of brucite
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Campione, M, Corti, M, D'Alessio, D, Capitani, G, Lucotti, A, Yivlialin, R, Tommasini, M, Bussetti, G, Malaspina, N, Campione, M, Corti, M, D'Alessio, D, Capitani, G, Lucotti, A, Yivlialin, R, Tommasini, M, Bussetti, G, and Malaspina, N
- Abstract
The water-mediated mineral carbonation represents a promising solution for the capture and the storage of atmospheric CO2. Even though this reaction might be spontaneous for a number of Mg- and Ca-rich mineral phases, it is characterized by considerable activation barriers. In order to make it effective, associated energy costs related to the achievement of adequate reaction conditions must be minimized. Microwave chemistry is known to provide for substantial increments of the reaction rate for several systems. We applied here microwave chemistry to the process of carbonation of aqueous slurries of brucite, a model system of Mg-rich mineral, subjected to partial pressures of CO2 as low as 6 bar and to no other additive. The temperature of the reactor was finely varied while the radiation power and the reactor pressure were monitored in real-time. The radiation power was used to estimate the radiation energy budget needed to complete the carbonation process, whereas the reactor pressure was used as a proxy of reaction progression. We show a detailed evolution of the carbonate products obtained in terms of mineral phases, morphological properties, and degree of crystallinity, both as precipitate and as solid residue in the exsiccated supernatant reaction liquid.
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- 2024
19. Backward facing step: from fluid flow to conjugate heat transfer with the coupling library preCICE.
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Caccia, C G, Corti, M, Della Torre, A, and Masarati, P
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- 2024
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20. Modulation of liver fibrosis and pathophysiological changes in mice infected with Mesocestoides corti (M. vogae) after administration of glucan and liposomized glucan in combination with vitamin C
- Author
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G. Ditteová, S. Velebný, and G. Hrčkova
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Vitamin ,Liver Cirrhosis ,Male ,medicine.medical_specialty ,beta-Glucans ,Aspartate transaminase ,Ascorbic Acid ,chemistry.chemical_compound ,Hydroxyproline ,Mice ,Mesocestoides ,Fibrosis ,Internal medicine ,medicine ,Animals ,Aspartate Aminotransferases ,Glucans ,Peritoneal Cavity ,Glucan ,chemistry.chemical_classification ,Drug Carriers ,Mice, Inbred ICR ,biology ,Vitamin C ,Anticestodal Agents ,Alanine Transaminase ,General Medicine ,Ascorbic acid ,medicine.disease ,Cestode Infections ,Endocrinology ,Alanine transaminase ,chemistry ,Liver ,Liposomes ,biology.protein ,Animal Science and Zoology ,Parasitology ,Drug Therapy, Combination ,Collagen - Abstract
The effects of glucan and liposomized glucan, alone or co-administered with vitamin C, and empty liposomes on hepatic fibrosis in mice infected with Mesocestoides corti (M. vogae) tetrathyridia were studied. Preparations were administered every third day from day 7 to day 31 post-infection (p.i.), nine doses in total. Activities of alanine aminotransferase (ALT), aspartate aminotransferase (AST) and cholesterol levels were measured in sera collected on days 11, 15, 21, 28, 32, 42, 50 and 65 p.i. Liver fibrosis was studied on the same days by measuring hydroxyproline concentration, which is considered a marker for collagen content. Larvicidal effects of the glucan and liposome preparations were estimated on day 65 p.i. in the liver and peritoneal cavity. Glucan formulations significantly enhanced collagen content, most prominently after administration of liposomized glucan in combination with vitamin C. Activities of both enzymes and cholesterol levels were slightly modified after administration of glucan alone. Liposomized glucan with vitamin C significantly increased ALT and AST activity and cholesterol levels up to days 28–32 p.i., after which they plateaued or declined. The most pronounced decrease was after administration of liposomized glucan and vitamin C. The same pattern of biochemical parameters in serum was observed after administration of empty liposomes, however, collagen content was not modified significantly. Larval counts in the liver and the peritoneal cavity were significantly reduced after treatment with either glucan formulation, but were unaffected following treatment with empty liposomes. In summary, intense fibrosis in the liver of mice treated with liposomized glucan and vitamin C did not result in the most extensive parenchymal cell injury but, rather in the highest efficacy of treatment. Liposomal lipids were probably utilized in the reparation of the damaged parenchymal cells, while glucan stimulated phagocytic cells.
- Published
- 2003
21. Accuracy in evaluating convective heat transfer coefficient by RANS CFD simulations in a rectangular channel with high aspect ratio and 60° tilted staggered ribs
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Corti, M, primary, Gramazio, P, additional, Fustinoni, D, additional, and Niro, A, additional
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- 2024
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22. A majority rule approach for region-of-interest-guided streamline fiber tractography
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Colon-Perez, LM, Triplett, W, Bohsali, A, Corti, M, Nguyen, PT, Patten, C, Mareci, TH, and Price, CC
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Cancer ,Biomedical Imaging ,Adult ,Cerebral Cortex ,Diffusion Magnetic Resonance Imaging ,Functional Laterality ,Humans ,Image Processing ,Computer-Assisted ,Male ,Observer Variation ,Pyramidal Tracts ,Reproducibility of Results ,White Matter ,Semi-manual segmentation ,Tractography ,Cortico-spinal tract ,Majority rules ROI ,Medical and Health Sciences ,Psychology and Cognitive Sciences ,Experimental Psychology - Abstract
Hand-drawn gray matter regions of interest (ROI) are often used to guide the estimation of white matter tractography, obtained from diffusion-weighted magnetic resonance imaging (DWI), in healthy and in patient populations. However, such ROIs are vulnerable to rater bias of the individual segmenting the ROIs, scan variability, and individual differences in neuroanatomy. In this report, a "majority rule" approach is introduced for ROI segmentation used to guide streamline tractography in white matter structures. DWI of one healthy participant was acquired in ten separate sessions using a 3 T scanner over the course of a month. Four raters identified ROIs within the left hemisphere [Cerebral Peduncle (CPED); Internal Capsule (IC); Hand Portion of the Motor Cortex, or Hand Bump, (HB)] using a group-established standard operating procedure for ROI definition to guide the estimation of streamline tracts within the corticospinal tract (CST). Each rater traced the ROIs twice for each scan session. The overlap of each rater's two ROIs was used to define a representative ROI for each rater. These ROIs were combined to create a "majority rules" ROI, in which the rule requires that each voxel is selected by at least three of four raters. Reproducibility for ROIs and CST segmentations were analyzed with the Dice Similarity Coefficient (DSC). Intra-rater reliability for each ROI was high (DSCs ≥ 0.83). Inter-rater reliability was moderate to adequate (DSC range 0.54-0.75; lowest for IC). Using intersected majority rules ROIs, the resulting CST showed improved overlap (DSC = 0.82) in the estimated streamline tracks for the ten sessions. Despite high intra-rater reliability, there was lower inter-rater reliability consistent with the expectation of rater bias. Employing the majority rules method improved reliability in the overlap of the CST.
- Published
- 2016
23. A deep and wide-field view at the IC 2944 / 2948 complex in Centaurus
- Author
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Baume, G., Rodríguez, M. J., Corti, M. A., Carraro, G., and Panei, J. A.
- Subjects
Astrophysics - Solar and Stellar Astrophysics ,Astrophysics - Astrophysics of Galaxies - Abstract
We employed the ESO MPI wide-field camera and obtained deep images in the VIc pass-bands in the region of the IC 2944/2948 complex (l ~ 294; b ~ -1), and complemented them with literature and archival data. We used this material to derive the photometric, spectroscopic and kinematic properties of the brightest (V < 16) stars in the region. The VI deep photometry on the other end, helped us to unravel the lower main sequence of a few, possibly physical, star groups in the area. Our analysis confirmed previous suggestions that the extinction toward this line of sight follows the normal law (Rv = 3.1). We could recognize B-type stars spread in distance from a few hundred pc to at least 2 kpc. We found two young groups (age ~ 3 Myr) located respectively at about 2.3 and 3.2 kpc from the Sun. They are characterized by a significant variable extinction (E(B-V) ranging from 0.28 to 0.45 mag), and host a significant pre-main sequence population. We computed the initial mass functions for these groups and obtained slopes Gamma from -0.94 to -1.02 (e_Gamma = 0.3), in a scale where the classical Salpeter law is -1.35. We estimated the total mass of both main stellar groups in ~ 1100$ and ~ 500$ Mo, respectively. Our kinematic analysis indicated that both groups of stars deviate from the standard rotation curve of the Milky Way, in line with literature results for this specific Galactic direction. Finally, along the same line of sight we identified a third group of early-type stars located at ~ 8 kpc from the Sun. This group might be located in the far side of the Sagittarius-Carina spiral arm., Comment: 13 pages, 11 figures, accepted for publication in MNRAS
- Published
- 2014
- Full Text
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24. Modulation of liver fibrosis and pathophysiological changes in mice infected with Mesocestoides corti(M. vogae) after administration of glucan and liposomized glucan in combination with vitamin C
- Abstract
AbstractThe effects of glucan and liposomized glucan, alone or co-administered with vitamin C, and empty liposomes on hepatic fibrosis in mice infected with Mesocestoides corti(M. vogae) tetrathyridia were studied. Preparations were administered every third day from day 7 to day 31 post-infection (p.i.), nine doses in total. Activities of alanine aminotransferase (ALT), aspartate aminotransferase (AST) and cholesterol levels were measured in sera collected on days 11, 15, 21, 28, 32, 42, 50 and 65 p.i. Liver fibrosis was studied on the same days by measuring hydroxyproline concentration, which is considered a marker for collagen content. Larvicidal effects of the glucan and liposome preparations were estimated on day 65 p.i. in the liver and peritoneal cavity. Glucan formulations significantly enhanced collagen content, most prominently after administration of liposomized glucan in combination with vitamin C. Activities of both enzymes and cholesterol levels were slightly modified after administration of glucan alone. Liposomized glucan with vitamin C significantly increased ALT and AST activity and cholesterol levels up to days 28?32 p.i., after which they plateaued or declined. The most pronounced decrease was after administration of liposomized glucan and vitamin C. The same pattern of biochemical parameters in serum was observed after administration of empty liposomes, however, collagen content was not modified significantly. Larval counts in the liver and the peritoneal cavity were significantly reduced after treatment with either glucan formulation, but were unaffected following treatment with empty liposomes. In summary, intense fibrosis in the liver of mice treated with liposomized glucan and vitamin C did not result in the most extensive parenchymal cell injury but, rather in the highest efficacy of treatment. Liposomal lipids were probably utilized in the reparation of the damaged parenchymal cells, while glucan stimulated phagocytic cells.
- Published
- 2003
- Full Text
- View/download PDF
25. Microwave-matter interaction for enhanced carbon capture by mineral carbonation
- Author
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Alzani, B, Bellacosa, M, Bianchi Bazzi, G, Yivlialin, R, Campione, M, Corti, M, Capitani, G, Lucotti, A, Tommasini, M, Bussetti, G, Malaspina, N, Corti, M., Lucotti A, Alzani, B, Bellacosa, M, Bianchi Bazzi, G, Yivlialin, R, Campione, M, Corti, M, Capitani, G, Lucotti, A, Tommasini, M, Bussetti, G, Malaspina, N, Corti, M., and Lucotti A
- Abstract
The formation of stable and insoluble Mg- and Ca-carbonates and/or hydroxy-carbonate hydrates, through water-mediated reaction of Mg(OH)2 (brucite) and Ca(OH)2 (portlandite) with carbon dioxide, is referred to as mineral carbonation (MC). MC is among the most promising potential solutions for long-term carbon capture and storage (CCS), since it is spontaneous under a wide range of conditions. However, kinetic barriers pose severe limitations to the practical exploitation of MC, implying energy requirements to reach sufficiently high reaction rates. Trying to overcome these hindrances, we show here the application of microwave (MW)-assisted processes for the carbonation of brucite, used as a model system for the carbonation occurring in a number of widely diffused minerals, such as serpentine. The mechanism, kinetics, and energy costs of the reaction, together with the chemical characteristics of the products obtained, are inferred by a combined study, carried out by both a MW synthesizer on bulk brucite water slurries and a purposedly developed microscopy platform, working on nano-scale regions of the surface of brucite single crystals.
- Published
- 2023
26. Photometric and spectroscopic variations of the Be star HD 112999
- Author
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Corti, M. A., Gamen, R. C., Aidelman, Y. J., Ferrero, G. A., and Weidmann, W. A.
- Subjects
Astrophysics - Solar and Stellar Astrophysics - Abstract
Be objects are stars of B spectral type showing lines of the Balmer series in emission. The presence of these lines is attributed to the existence of an extended envelope, disk type, around them. Some stars are observed in both the Be and normal B-type spectroscopic states and they are known as transient Be stars. In this paper we show the analysis carried out on a new possible transient Be star, labelled HD 112999, using spectroscopic optical observations and photometric data., Comment: 10 pages, 5 figures, accepted for publication in IBVS
- Published
- 2013
27. Glassy Transition in the Vortex Lattice of Ba(Fe0.93Rh0.07)2As2 superconductor, probed by NMR and ac-susceptibility
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Bossoni, L., Carretta, P., Horvatić, M., Corti, M., Thaler, A., and Canfield, P. C.
- Subjects
Condensed Matter - Superconductivity ,Condensed Matter - Strongly Correlated Electrons - Abstract
By using Nuclear Magnetic Resonance and ac-susceptibility, the characteristic correlation times for the vortex dynamics, in an iron-based superconductor, have been derived. Upon cooling, the vortex dynamics displays a crossover consistent with a vortex glass transition. The correlation times, in the fast motions regime, merge onto a universal curve which is fit by the Vogel-Fulcher law, rather than by an Arrhenius law. Moreover, the pinning barrier shows a weak dependence on the magnetic field which can be heuristically justified within a fragile glass scenario. In addition, the glass freezing temperatures obtained by the two techniques merge onto the de Almeida-Thouless line. Finally the phase diagram for the mixed phase has been derived., Comment: 6 pages, 9 figures
- Published
- 2012
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28. GS305+04-26:Revisiting the ISM around the CenOB1 stellar association
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Corti, M. A., Arnal, E. M., and Orellana, R. B.
- Subjects
Astrophysics - Astrophysics of Galaxies - Abstract
Massive stars deeply modify their surrounding ISM via their high throughput of ionizing photons and their strong stellar winds. In this way they may create large expanding structures of neutral gas. We study a new large HI shell, labelled GS305+04-26, and its relationship with the OB association CenOB1. To carry out this study we have used a multi-wavelenght approach. We analyze neutral hydrogen (HI) line data retrieved from the Leiden-Argentina-Bonn (LAB) survey, new spectroscopic optical observations obtained at CASLEO, and make use of proper motion databases available via Internet. The analysis of the HI data reveals a large expanding structure GS305+04-26 centered at (l,b)=(305$^{\degr}$, +4$^{\degr}$) in the velocity range from -33 to -17 km/s. Based on its central velocity, -26 km/s, and using standard galactic rotation models, a distance of 2.5(+-)0.9 kpc is inferred. This structure, elliptical in shape, has major and minor axis of 440 and 270 pc, respectively. Its expansion velocity, total gaseous mass, and kinetic energy are ~8 km/s, (2.4(+-)0.5)x10^5 Mo, and (1.6(+-)0.4)x10^{50} erg, respectively. Several stars of the OB-association CenOB1 are seen projected onto, and within, the boundaries of GS305+04-26. Based on an analysis of proper motions, new members of CenOB1 are identified. The mechanical energy injected by these stars could have been the origin of this HI structure., Comment: 14 pages, 6 figures, A&A (in press)
- Published
- 2012
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29. NGC 3503 and its molecular environment
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Duronea, N. U., Vasquez, J., Cappa, C. E., Corti, M., and Arnal, E. M.
- Subjects
Astrophysics - Astrophysics of Galaxies - Abstract
We present a study of the molecular gas and interstellar dust distribution in the environs of the HII region NGC 3503 associated with the open cluster Pis 17 with the aim of investigating the spatial distribution of the molecular gas linked to the nebula and achieving a better understanding of the interaction of the nebula and Pis 17 with their molecular environment. We based our study in ^{12}CO(1-0) observations of a region of ~0.6 deg. in size obtained with the 4-m NANTEN telescope, unpublished radio continuum data at 4800 and 8640 MHz obtained with the ATCA telescope, radio continuum data at 843 MHz obtained from SUMSS, and available IRAS, MSX, IRAC-GLIMPSE, and MIPSGAL images. We found a molecular cloud (Component 1) having a mean velocity of -24.7 km s^{-1}, compatible with the velocity of the ionized gas, which is associated with the nebula and its surroundings. Adopting a distance of 2.9 +/- 0.4 kpc the total molecular mass and density yield (7.6 +/- 2.1) x 10^3 Msun and 400 +/- 240 cm^{-3}, respectively. The radio continuum data confirm the existence of an electron density gradient in NGC 3503. The IR emission shows the presence of a PDR bordering the higher density regions of the nebula. The spatial distribution of the CO emission shows that the nebula coincides with a molecular clump, with the strongest CO emission peak located close to the higher electron density region. The more negative velocities of the molecular gas (about -27 km s^{-1}), is coincident with NGC 3503. Candidate YSOs were detected towards the HII region, suggesting that embedded star formation may be occurring in the neighbourhood of the nebula. The presence of a clear electron density gradient, along with the spatial distribution of the molecular gas and PAHs in the region indicates that NGC 3503 is a blister-type HII region that probably has undergone a champagne phase.
- Published
- 2011
- Full Text
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30. Corti, M., Ombre dal fondo; Torino, Einaudi, 1997
- Author
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Zangenfeind, Sabine
- Subjects
Institut für Romanistik - Published
- 1998
31. Exploring tau protein and amyloid-beta propagation: a sensitivity analysis of mathematical models based on biological data.
- Author
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Corti M
- Abstract
Alzheimer's disease is the most common dementia worldwide. Its pathological development is well known to be connected with the accumulation of two toxic proteins: tau protein and amyloid-$\beta$. Mathematical models and numerical simulations can predict the spreading patterns of misfolded proteins in this context. However, the calibration of the model parameters plays a crucial role in the final solution. In this work, we perform a sensitivity analysis of heterodimer and Fisher-Kolmogorov models to evaluate the impact of the equilibrium values of protein concentration on the solution patterns. We adopt advanced numerical methods such as the IMEX-DG method to accurately describe the propagating fronts in the propagation phenomena in a polygonal mesh of sagittal patient-specific brain geometry derived from magnetic resonance images. We calibrate the model parameters using biological measurements in the brain cortex for the tau protein and the amyloid-$\beta$ in Alzheimer's patients and controls. Finally, using the sensitivity analysis results, we discuss the applicability of both models in the correct simulation of the spreading of the two proteins.
- Published
- 2024
32. Neurological glycogen storage diseases and emerging therapeutics.
- Author
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Colpaert M, Singh PK, Donohue KJ, Pires NT, Fuller DD, Corti M, Byrne BJ, Sun RC, Vander Kooi CW, and Gentry MS
- Subjects
- Humans, Animals, Glycogen metabolism, Enzyme Replacement Therapy methods, Nervous System Diseases therapy, Nervous System Diseases metabolism, Glycogen Storage Disease therapy, Glycogen Storage Disease metabolism, Glycogen Storage Disease genetics, Genetic Therapy methods, Genetic Therapy trends
- Abstract
Glycogen storage diseases (GSDs) comprise a group of inherited metabolic disorders characterized by defects in glycogen metabolism, leading to abnormal glycogen accumulation in multiple tissues, most notably affecting the liver, skeletal muscle, and heart. Recent findings have uncovered the importance of glycogen metabolism in the brain, sustaining a myriad of physiological functions and linking its perturbation to central nervous system (CNS) pathology. This link resulted in classification of neurological-GSDs (n-GSDs), a group of diseases with shared deficits in neurological glycogen metabolism. The n-GSD patients exhibit a spectrum of clinical presentations with common etiology while requiring tailored therapeutic approaches from the traditional GSDs. Recent research has elucidated the genetic and biochemical mechanisms and pathophysiological basis underlying different n-GSDs. Further, the last decade has witnessed some promising developments in novel therapeutic approaches, including enzyme replacement therapy (ERT), substrate reduction therapy (SRT), small molecule drugs, and gene therapy targeting key aspects of glycogen metabolism in specific n-GSDs. This preclinical progress has generated noticeable success in potentially modifying disease course and improving clinical outcomes in patients. Herein, we provide an overview of current perspectives on n-GSDs, emphasizing recent advances in understanding their molecular basis, therapeutic developments, underscore key challenges and the need to deepen our understanding of n-GSDs pathogenesis to develop better therapeutic strategies that could offer improved treatment and sustainable benefits to the patients., Competing Interests: Declaration of competing interest R.C.S. has received research support and consultancy fees from Maze Therapeutics and is a member of the Medical Advisory Board for Little Warrior Foundation. M.S.G. has received research support, research compounds, or consultancy fees from Maze Therapeutics, Valerion Therapeutics, Ionis Pharmaceuticals, PTC Therapeutics, and the Glut1-Deficiency Syndrome Foundation. R.C.S. and M.S.G. are co-founders of Attrogen LLC. M.Corti has received research support from Sanofi, Friedreich Ataxia Research Alliance (FARA), Amicus, AavantiBio, Lacerta, Provention Bio, Sarepta, Duchenne Research Fund, Muscular Dystrophy Association (MDA), GoFAR, Cydan, Audentes. M.Corti has received consulting fees from AavantiBio, Reata, Lilly, Avexis and Gilbert foundation, SwanBio and PCT Therapeutics. B.J.B. has received research support from SolidBio, ProventionBio, Barth Syndrome Foundation. B.J.B. has received consulting fees from AavantiBio, Amicus Therapeutics, Rocket Pharma, Pfizer, Sanofi, and Sarepta Therapeutics. M.Corti and B.J.B. are co-founders of Ventura, LLC., (Copyright © 2024 The Author(s). Published by Elsevier Inc. All rights reserved.)
- Published
- 2024
- Full Text
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33. Emerging therapies in hereditary ataxias.
- Author
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Eisel MLS, Burns M, Ashizawa T, Byrne B, Corti M, and Subramony SH
- Abstract
Recent investigations have defined the pathophysiological basis of many hereditary ataxias (HAs), including loss-of-function as well as gain-of-function mechanisms at either the RNA or protein level. Preclinical studies have assessed gene editing, gene and protein replacement, gene enhancement, and gene knockdown strategies. Methodologies include viral vector delivery of genes, oligonucleotide therapies, cell-penetrating peptides, synthetic transcription factors, and technologies to deliver therapies to defined targets. In this review, we focus on Friedreich ataxia (FRDA) and the polyglutamine ataxias in which translational research is active. However, much remains to be done to identify safe and effective molecules, create ideal delivery methods, and perform innovative clinical trials to prove the safety and efficacy of treatments for these rare but devastating diseases., Competing Interests: Declaration of interests S.H.S. has received research support from the following for conducting clinical trials and studies on disorders dealt with in this review: Reata Pharmaceuticals, Retrotope, PTC therapeutics, Biogen, Biohaven, NINDS NS UO 1, National Ataxia Foundation, and Friedreich Ataxia Research Alliance. T.A. has received research support from the following for conducting clinical trials and studies on disorders dealt with in this review: Biogen, Biohaven, and NINDS NS UO1. B.B., M.C., M.B., and M.E. have no conflicting interests to declare., (Copyright © 2024. Published by Elsevier Ltd.)
- Published
- 2024
- Full Text
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34. A discontinuous Galerkin method for the three-dimensional heterodimer model with application to prion-like proteins' dynamics.
- Author
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Antonietti PF, Corti M, and Lorenzon G
- Abstract
Neurocognitive disorders, such as Alzheimer's and Parkinson's, have a wide social impact. These proteinopathies involve misfolded proteins accumulating into neurotoxic aggregates. Mathematical and computational models describing the prion-like dynamics offer an analytical basis to study the diseases' evolution and a computational framework for exploring potential therapies. This work focuses on the heterodimer model in a three-dimensional setting, a reactive-diffusive system of nonlinear partial differential equations describing the evolution of both healthy and misfolded proteins. We investigate traveling wave solutions and diffusion-driven instabilities as a mechanism of neurotoxic pattern formation. For the considered mathematical model, we propose a space discretization, relying on the Discontinuous Galerkin method on polytopal/polyhedral grids, allowing high-order accuracy and flexible handling of the complicated brain's geometry. Further, we present a priori error estimates for the semi-discrete formulation and we perform convergence tests to verify the theoretical results. Finally, we conduct simulations using realistic data on a three-dimensional brain mesh reconstructed from medical images.
- Published
- 2024
35. APPLICATION OF LUCAS-KANADE DENSE FLOW FOR TERRAIN MOTION IN LANDSLIDE MONITORING APPLICATION
- Author
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Yordanov, V., primary, Truong, X. Q., additional, Corti, M., additional, Longoni, L., additional, and Brovelli, M. A., additional
- Published
- 2023
- Full Text
- View/download PDF
36. Accuracy in evaluating convective heat transfer coefficient by RANS CFD simulations in a rectangular channel with high aspect ratio and 60° tilted staggered ribs.
- Author
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Corti, M, Gramazio, P, Fustinoni, D, and Niro, A
- Published
- 2023
- Full Text
- View/download PDF
37. Interferometric investigation of the gas-state monolayer of mono-rhamnolipid adsorbing at an oil/water interface
- Author
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Brocca, P., Rondelli, V., Corti, M., Del Favero, E., Deleu, M., and Cantù, L.
- Published
- 2018
- Full Text
- View/download PDF
38. Polar and non-polar atomic motions in the relaxor ferroelectric PLZT from dielectric, anelastic and NMR relaxation
- Author
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Cordero, F., Corti, M., Craciun, F., Galassi, C., Piazza, D., and Tabak, F.
- Subjects
Condensed Matter - Materials Science - Abstract
Dielectric, anelastic and ^139La NMR relaxation measurements have been made on the relaxor ferroelectric Pb(1-3x/2)La(x)Zr(0.2)Ti(0.8)O(3) (PLZT) with x = 0.22. The dielectric susceptibility exihibits the frequency dispersive maximum due to the freezing of the polar degrees of freedom around T ~250 K. The anelastic and especially NMR relaxation, besides this maximum, indicate an intense and broad component at lower temperatures, attributed to rotational modes of the O octahedra, weakly coupled to the polar modes. It is discussed why such short range rotational instabilities, known to occur in the Zr-rich rhombohedral region of the PLZT phase diagram, might appear also in the Ti-rich region., Comment: submitted to Phys. Rev. B, 9 pages, 10 figures
- Published
- 2004
- Full Text
- View/download PDF
39. Optical spectroscopy of X-Mega targets in the Carina Nebula. II. The massive double-lined O-type binary HD 93205
- Author
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Morrell, N. I., Barba, R. H., Niemela, V. S., Corti, M. A., Colombo, J. F. Albacete, Rauw, G., Corcoran, M., Morel, T., Bertrand, J. -F., Moffat, A. F. J., and St-Louis, N.
- Subjects
Astrophysics - Abstract
A new high-quality set of orbital parameters for the O-type spectroscopic binary HD93205 has been obtained combining echelle and coude CCD observations. The radial velocity orbits derived from the HeII 4686 A (primary component) and HeI 4471 A (secondary component) absorption lines yield semiamplitudes of 133 +/- 2 and 314 +/- 2 km/s for each binary component, resulting in minimum masses of 31 and 13 Msol (q = 0.42). We also confirm for the binary components the spectral classification of O3V+O8V previously assigned. Assuming for the O8V component a ``normal'' mass of 22 - 25 Msol we would derive for the primary O3V a mass of ``only'' 52 - 60 Msol and an inclination of about 55 degrees for the orbital plane. We have also determined for the first time a period of apsidal motion for this system, namely 185 +/- 16 years using all available radial velocity data-sets of HD 93205 (from 1975 to 1999). Phase-locked variations of the X-ray emission of HD 93205 consisting of a rise of the observed X-ray flux near periastron passage, are also discussed., Comment: 11 pages, 8 Figures, Accepted by MNRAS (April 2001)
- Published
- 2001
- Full Text
- View/download PDF
40. Anelastic relaxation and $^{139}$La NQR in La$_{2-x}$Sr$_x$CuO$_4$ around the critical Sr content x=0.02
- Author
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Campana, A., Corti, M., Rigamonti, A., Cantelli, R., and Cordero, F.
- Subjects
Condensed Matter - Superconductivity ,Condensed Matter - Strongly Correlated Electrons - Abstract
Anelastic relaxation and $^{139}$La NQR relaxation measurements in La$_{2-x}$Sr$_x$CuO$_4$ for Sr content x around 2 and 3 percent, are presented and discussed in terms of spin and lattice excitations and ordering processes. It is discussed how the phase diagram of La$_{2-x}$Sr$_x$CuO$_4$ at the boundary between the antiferromagnetic (AF) and the spin-glass phase (x = 0.02) could be more complicate than previous thought, with a transition to a quasi-long range ordered state at T = 150 K, as indicated by recent neutron scattering data. On the other hand, the $^{139}$La NQR spectra are compatible with a transition to a conventional AF phase around T = 50 K, in agreement with the phase diagram commonly accepted in the literature. In this case the relaxation data, with a peak of magnetic origin in the relaxation rate around 150 K at 12 MHz and the anelastic counterparts around 80 K in the kHz range, yield the first evidence in La$_{1.98}$Sr$_{0.02}$CuO$_4$ of freezing involving simultaneously lattice and spin excitations. This excitation could correspond to the motion of charged stripes., Comment: 10 pages, 8 figures
- Published
- 2000
- Full Text
- View/download PDF
41. Tilt waves dynamics of the oxygen octahedra in La2CuO4 from anelastic and 139La NQR relaxation
- Author
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Cordero, F., Cantelli, R., Corti, M., Campana, A., and Rigamonti, A.
- Subjects
Condensed Matter - Superconductivity - Abstract
The anharmonic vibrational dynamics in nearly stoichiometric La2CuO4+delta is studied by means of anelastic and ^{139}La NQR relaxation. In the absorption component of the elastic susceptibility as well as in the nuclear relaxation rate a peak is detected as a function of temperature, and a relaxation time tau = 1.7 10^{-12} exp [(2800 K)/T] s is derived. The relaxation processes are attributed to tilt motion of the CuO6 octahedra in doublewell potentials, whose cooperative character increases the effective energy barrier to the observed value. The analysis of the relaxation mechanisms has been carried out by reducing the dynamics of the interacting octahedra to a one-dimensional equation of motion. The soliton-like solutions correspond to parallel walls separating domains of different tilt patterns and give rise to pseudo-diffusive modes which appear as a central component in the spectral density of the motion of the octahedra. The tilt waves may be considered to correspond to the dynamical lattice stripes observed in La-based and Bi-based high-Tc superconductors., Comment: LaTeX, 3 PostScript figures, to be published in Phys. Rev. B
- Published
- 1999
- Full Text
- View/download PDF
42. CO2 emissions and mineral nitrogen dynamics following application to soil of undigested liquid cattle manure and digestates
- Author
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Cavalli, D., Corti, M., Baronchelli, D., Bechini, L., and Marino Gallina, P.
- Published
- 2017
- Full Text
- View/download PDF
43. Water response to ganglioside GM1 surface remodelling
- Author
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Brocca, P., Rondelli, V., Mallamace, F., Di Bari, M.T., Deriu, A., Lohstroh, W., Del Favero, E., Corti, M., and Cantu’, L.
- Published
- 2017
- Full Text
- View/download PDF
44. Self-assembly of heterochiral, aliphatic dipeptides with Leu.
- Author
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Scarel E, De Corti M, Polentarutti M, Pierri G, Tedesco C, and Marchesan S
- Subjects
- Crystallography, X-Ray, Solvents, Water, Dipeptides chemistry, Peptides chemistry
- Abstract
This work describes the self-assembly behavior of heterochiral, aliphatic dipeptides, l-Leu-d-Xaa (Xaa = Ala, Val, Ile, Leu), in green solvents such as acetonitrile (MeCN) and buffered water at neutral pH. Interestingly, water plays a structuring role because at 1% v/v, it enables dipeptide self-assembly in MeCN to yield organogels, which then undergo transition towards crystals. Other organic solvents and oils were tested for gelation, and metastable gels were formed in tetrahydrofuran, although at high peptide concentration (80 mM). Single-crystal X-ray diffraction revealed the dipeptides' supramolecular packing modes in amphipathic layers, as opposed to water channels reported for the homochiral Leu-Leu, or hydrophobic columns reported for homochiral Leu-Val and Leu-Ile., (© 2023 The Authors. Journal of Peptide Science published by European Peptide Society and John Wiley & Sons Ltd.)
- Published
- 2024
- Full Text
- View/download PDF
45. Longitudinal changes of swallowing safety and efficiency in infants with spinal muscular atrophy who received disease modifying therapies.
- Author
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Leon-Astudillo C, Brooks O, Salabarria SM, Coker M, Corti M, Lammers J, Plowman EK, Byrne BJ, and Smith BK
- Subjects
- Humans, Male, Infant, Female, Infant, Newborn, Longitudinal Studies, Muscular Atrophy, Spinal physiopathology, Muscular Atrophy, Spinal drug therapy, Fluoroscopy, Child, Preschool, Deglutition Disorders physiopathology, Deglutition Disorders etiology, Deglutition physiology
- Abstract
Background: Dysphagia is a common feature of the natural history of patients with spinal muscular atrophy (SMA). Literature regarding swallowing safety and efficiency is scarce in patients with SMA, particularly in the era of newborn screening programs and disease-modifying therapies., Objective: To describe the longitudinal changes of swallowing safety and efficiency in children with SMA who received one or more disease modifying therapies METHODS: Case series of patients with SMA followed at the University of Florida from 1 May 2019 to 31 December 2022 who had two or more videofluoroscopy swallowing studies (VFSS), with the first being within 30 days of their first treatment. Data extracted from the electronic health record included: neuromotor outcomes, VFSS penetration aspiration scores (PAS), presence of abrnormal oral or pharyngeal residue, clinical history, and timing of disease-modifying therapies administration., Results: Seven subjects were included (five male); three were diagnosed via newborn screen. Median age at diagnosis was 10 days (range: 4-250). Median age at initial VFSS was 29 days (range: 9-246), and age at the last VFSS was 26.1 months (range: 18.2-36.2). All subjects received onasemnogene-abeparvovec (OA); four received additional therapies. PAS at diagnosis was abnormal in four subjects. Six subjects required feeding modifications after VFSS results. Of these, three had silent aspiration (PAS 8) and three of them improved after treatment., Conclusions: Swallowing safety and efficiency can be impaired in patients with SMA despite early treatment. Larger, prospective studies are needed to define optimal timiing of longitudinal instrumental evaluations., (© 2024 Wiley Periodicals LLC.)
- Published
- 2024
- Full Text
- View/download PDF
46. The multifaceted roles of the brain glycogen.
- Author
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Markussen KH, Corti M, Byrne BJ, Vander Kooi CW, Sun RC, and Gentry MS
- Subjects
- Animals, Humans, Glycogen Storage Disease metabolism, Brain metabolism, Glycogen metabolism
- Abstract
Glycogen is a biologically essential macromolecule that is directly involved in multiple human diseases. While its primary role in carbohydrate storage and energy metabolism in the liver and muscle is well characterized, recent research has highlighted critical metabolic and non-metabolic roles for glycogen in the brain. In this review, the emerging roles of glycogen homeostasis in the healthy and diseased brain are discussed with a focus on advancing our understanding of the role of glycogen in the brain. Innovative technologies that have led to novel insights into glycogen functions are detailed. Key insights into how cellular localization impacts neuronal and glial function are discussed. Perturbed glycogen functions are observed in multiple disorders of the brain, including where it serves as a disease driver in the emerging category of neurological glycogen storage diseases (n-GSDs). n-GSDs include Lafora disease (LD), adult polyglucosan body disease (APBD), Cori disease, Glucose transporter type 1 deficiency syndrome (G1D), GSD0b, and late-onset Pompe disease (PD). They are neurogenetic disorders characterized by aberrant glycogen which results in devastating neurological and systemic symptoms. In the most severe cases, rapid neurodegeneration coupled with dementia results in death soon after diagnosis. Finally, we discuss current treatment strategies that are currently being developed and have the potential to be of great benefit to patients with n-GSD. Taken together, novel technologies and biological insights have resulted in a renaissance in brain glycogen that dramatically advanced our understanding of both biology and disease. Future studies are needed to expand our understanding and the multifaceted roles of glycogen and effectively apply these insights to human disease., (© 2023 International Society for Neurochemistry.)
- Published
- 2024
- Full Text
- View/download PDF
47. Late Mortality, Subsequent Malignant Neoplasms and Hospitalisations in Long-Term Survivors of Adolescent and Young Adult Hematological Cancers
- Author
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Trama, A, Vener, C, Lasalvia, P, Bernasconi, A, Zorzi, M, Andreano, A, Contiero, P, Manneschi, G, Falcini, F, Castaing, M, Filiberti, R, Gasparotti, C, Cirilli, C, Amodio, R, Bisceglia, I, Iacovacci, S, Vitale, M, Stracci, F, Gentilini, M, Tumino, R, Carone, S, Sampietro, G, Melcarne, A, Gatti, L, Boschetti, L, Corti, M, Rognoni, M, Coviello, E, Pesce, M, D'Orsi, G, Fanetti, A, De Lorenzis, L, Candela, G, Savoia, F, Pascucci, C, Castelli, M, Storchi, C, Trama A., Vener C., Lasalvia P., Bernasconi A., Zorzi M., Andreano A., Contiero P., Manneschi G., Falcini F., Castaing M., Filiberti R. A., Gasparotti C., Cirilli C., Amodio R., Bisceglia I., Iacovacci S., Vitale M. F., Stracci F., Gentilini M. A., Tumino R., Carone S., Sampietro G., Melcarne A., Gatti L., Boschetti L., Corti M., Rognoni M., Coviello E., Pesce M. T., D'Orsi G., Fanetti A. C., De Lorenzis L., Candela G., Savoia F., Pascucci C., Castelli M., Storchi C., Trama, A, Vener, C, Lasalvia, P, Bernasconi, A, Zorzi, M, Andreano, A, Contiero, P, Manneschi, G, Falcini, F, Castaing, M, Filiberti, R, Gasparotti, C, Cirilli, C, Amodio, R, Bisceglia, I, Iacovacci, S, Vitale, M, Stracci, F, Gentilini, M, Tumino, R, Carone, S, Sampietro, G, Melcarne, A, Gatti, L, Boschetti, L, Corti, M, Rognoni, M, Coviello, E, Pesce, M, D'Orsi, G, Fanetti, A, De Lorenzis, L, Candela, G, Savoia, F, Pascucci, C, Castelli, M, Storchi, C, Trama A., Vener C., Lasalvia P., Bernasconi A., Zorzi M., Andreano A., Contiero P., Manneschi G., Falcini F., Castaing M., Filiberti R. A., Gasparotti C., Cirilli C., Amodio R., Bisceglia I., Iacovacci S., Vitale M. F., Stracci F., Gentilini M. A., Tumino R., Carone S., Sampietro G., Melcarne A., Gatti L., Boschetti L., Corti M., Rognoni M., Coviello E., Pesce M. T., D'Orsi G., Fanetti A. C., De Lorenzis L., Candela G., Savoia F., Pascucci C., Castelli M., and Storchi C.
- Abstract
Background: Increased success in the treatment of hematological cancers contributed to the increase of 5-year survival for most adolescent and young adults (AYAs) with these tumours. However, as 5-year survival increased, it became clear that AYA long-term survivors were at increased risk for severe late effects. Moreover, limited information on long-term cancer impact is available for AYAs, since most studies focused on children and adolescents. We aimed to assess various long-term outcomes on AYA survivors of hematological cancers. Methods: We selected patients diagnosed with a first primary hematological cancer between 1997 and 2006, in the Italian nationwide population-based cohort of AYA cancer survivors (i.e. alive at least 5 years after cancer diagnosis). Long-term outcomes of interest were: second malignant neoplasms (SMNs), hospitalizations and overall mortality. We calculated standardized incidence ratios (SIRs), standardized hospitalization rate ratios (SHRs) and standardized mortality rate ratios (SMRs). To study morbidity patterns over time, we modeled observed incidence rates by fitting flexible parametric models for nonlinear patterns and we used linear regression for linear patterns. Results: The study cohort included 5,042 AYA hematological cancer survivors of which 1,237 and 3,805 had a leukaemia and lymphoma diagnosis, respectively. AYA survivors were at substantially increased risk for SMN (SIR=2.1; 95%CI=1.7; 2.6), hospitalisation (SHR=1.5; 95%CI=1.5; 1.6), and mortality (SMR=1.4; 95%CI=1.2; 1.6) with differences between leukaemia and lymphoma survivors. The highest excess risks of hospitalisations were for infectious diseases, respiratory diseases, and diseases of blood and blood-forming organs. The morbidity pattern differs over time by morbidity type. Conclusions: Our results support the need for strict follow-up plans for survivors, and call for further study to better personalised follow-up plans for AYA cancer survivors.
- Published
- 2022
48. Presentazione
- Author
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Bettetini, Andrea, Corti, Matteo, Maganzani, Lauretta, Bettetini A. (ORCID:0000-0002-3379-8501), Corti M. (ORCID:0000-0002-4066-7542), Maganzani L. (ORCID:0000-0002-8404-4240), Bettetini, Andrea, Corti, Matteo, Maganzani, Lauretta, Bettetini A. (ORCID:0000-0002-3379-8501), Corti M. (ORCID:0000-0002-4066-7542), and Maganzani L. (ORCID:0000-0002-8404-4240)
- Abstract
Presentazione di una serie di saggi ucraini destinati alla rivista JusOnline
- Published
- 2023
49. Site-specific recommendations of cattle manure nitrogen and urea for silage maize
- Author
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Corti, M, Cavalli, D, Pricca, N, Ferrè, C, Comolli, R, Gallina, P, Abu El Khair, D, Cabassi, G, Gallina, PM, Corti, M, Cavalli, D, Pricca, N, Ferrè, C, Comolli, R, Gallina, P, Abu El Khair, D, Cabassi, G, and Gallina, PM
- Abstract
A novel decision support system (DSS) was developed to define site-specific cattle manure rates with the aim of increasing the stable pool of soil organic matter. A site-specific N balance model calculated urea rates for maize at side-dress. Inputs to the DSS were derived from geophysical methods (soil texture), near infrared spectroscopy (NIR; soil C) and multispectral images of the crop and yield maps (maize N requirement). The DSS was compared to farmer fixed N rate (170 kg manure N ha−1 and 120–170 kg urea N ha−1) in a two-year field trial in Northern Italy. A replicated plot experiment was also established to study the effects of year, soil, and fertilizer rate on maize yield. Geophysical and NIR methods accurately mapped soil properties (errors < 20% for > 75% of the field compared to geostatistical mapping based on soil sampling and analysis). Site-specific application of manure and urea had high spatial accuracy (average error < 29 kg N ha−1 for > 81% of the field). The great impact of year and soil properties on silage yield and N uptake suggested adjusting spatially the in-season target yield to prevent over-fertilization. Compared to the fixed N management, the DSS showed no reduction in yield and N uptake, and some potential environmental benefits, especially for the low-yielding zone of the field (−80 kg applied N ha−1). Future evaluation of other soil types and environments would provide the necessary information to upgrade the DSS at a farm scale.
- Published
- 2023
50. Hydrothermal synthesis of chrysotile nanotubes and lizardite nanoflakes and investigation of their behaviour in microwave assisted carbonation
- Author
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Corti, M, Campione, M, Capitani, G, Malaspina, N, Corti, M, Campione, M, Capitani, G, and Malaspina, N
- Published
- 2023
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