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El doble artículo combina arte, memoria e historia individual y colectiva para ler la vida y la obra del pintor argentino Gustavo Cochet.

Este artigo propõe debruçar-se sobre o diário do artista argentino Gustavo Cochet, escrito em dois momentos: durante aos anos da Guerra Civil Espanhola e em seu retorno à Argentina, em 1940. A discussão pretende analisar a estruturação textual do diário e suas relações entre texto e imagem a partir da ideia de que essa produção de Cochet constitui-se como uma forma híbrida, configurada entre o testemunho autobiográfico, a reflexão estética de contornos ensaísticos e o aforismo.

Gustavo Cochet (1894-1979) is a key artist of our city. Member of the first generation of local artists, sample a peculiar approach to realism that exceeded the previous characterizations of art in Rosario. The presence of Atalaya (Alfredo Chiabra Acosta) and the circle of nearby artists to Martín Malharro in Rosario’s cultural circles, frequented by the young painter, his active participation in the cultural spaces of Barcelona and Paris (since of mid ‘10) and his militant adherence to the Spanish Republic, carved his sensitivity, marked by a strong anarchist posture and a full identification of art with the daily life.

Erb‐b2 receptor tyrosine kinase 2 (ERBB2)‐activating mutations are therapeutically actionable alterations found in various cancers, including metastatic breast cancer (MBC). We developed multiplex digital PCR assays to detect and quantify ERBB2 mutations in circulating tumor DNA from liquid biopsies. We studied the plasma from 272 patients with hormone‐receptor‐positive, human epidermal growth factor receptor 2‐negative (HR+/HER2−) MBC to detect 17 ERBB2 mutations using a screening assay. The assay was developed on the three‐color Crystal dPCR™ naica® platform with a two‐step strategy for precise mutation identification. We found that nine patients (3.3%) harbored at least one ERBB2 mutation. The mutation rate was higher in patients with lobular histology (5.9%) compared to invasive breast carcinoma of no special type (2.6%). A total of 12 mutations were found with the following frequencies: L755S (25.00%), V777L (25.00%), S310Y (16.67%), L869R (16.67%), S310F (8.33%), and D769H (8.33%). Matched tumor samples from six patients identified the same mutations with an 83% concordance rate. In summary, our highly sensitive multiplex digital PCR assays are well suited for plasma‐based monitoring of ERBB2 mutational status in patients with MBC.

The article reports on the discovery of a drawing by French sculptor Christophe Cochet which depicts the decor of the vault he sculpted in the Henri IV Gallery at the Palais de Luxembourg in Paris, France. The depiction of the palace by French architect and engraver Jean Marot and French architect Antoine Desgodets are also mentioned.

Abstract Background: The aim of this study is to investigate the added value of combining tumour blood flow (BF) and metabolism parameters, including texture features, with clinical parameters to predict, at baseline, the pathological complete response (pCR) to neoadjuvant chemotherapy (NAC) in patients with newly diagnosed breast cancer (BC). Methods: One hundred and twenty-eight BC patients underwent a 18F-FDG PET/CT before any treatment. Tumour BF and metabolism parameters were extracted from first-pass dynamic and delayed PET images, respectively. Standard and texture features were extracted from BF and metabolic images. Prediction of pCR was performed using logistic regression, random forest and support vector classification algorithms. Models were built using clinical (C), clinical and metabolic (C+M) and clinical, metabolic and tumour BF (C+M+BF) information combined. Algorithms were trained on 80% of the dataset and tested on the remaining 20%. Univariate and multivariate features selections were carried out on the training dataset. A total of 50 shuffle splits were performed. The analysis was carried out on the whole dataset (HER2 and Triple Negative (TN)), and separately in HER2 (N=76) and TN (N=52) tumours. Results: In the whole dataset, the highest classification performances were observed for C+M models, significantly (p-value

PET/CT is an imaging modality that is increasingly being used to diagnose large-vessel vasculitis. In the case of giant cell arteritis, it was first used to demonstrate inflammation of the walls of large arterial trunks such as the aorta and its main branches, showing that aortic involvement is common in this vasculitis and associated with the occurrence of aortic complications such as aneurysms. More recently, with the advent of digital PET/CT, study of the cranial arteries (i.e., temporal, occipital, maxillary and vertebral arteries) has become possible, further increasing the diagnostic interest of this examination for the diagnosis of GCA. Despite these advantages, there are still limitations and questions regarding the use of PET/CT for the diagnosis and especially the follow-up of GCA. The aim of this review is to take stock of currently available data on the use of PET/CT for GCA diagnosis and follow-up.