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2. Practical and technical key challenges in head and neck adaptive radiotherapy: The GORTEC point of view

Author

Delaby, Nolwenn, Barateau, Anaïs, Chiavassa, Sophie, Biston, Marie-Claude, Chartier, Philippe, Graulières, Eliane, Guinement, Lucie, Huger, Sandrine, Lacornerie, Thomas, Millardet-Martin, Corinne, Sottiaux, Alain, Caron, Jérôme, Gensanne, David, Pointreau, Yoann, Coutte, Alexandre, Biau, Julian, Serre, Anne-Agathe, Castelli, Joel, Tomsej, Milan, Garcia, Robin, Khamphan, Catherine, and Badey, Aurélien

Published
2023
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4. Monte Carlo simulations of microdosimetry and radiolytic species production at long time post proton irradiation using GATE and Geant4‐DNA.

Author

Fois, Giovanna Rosa, Tran, Hoang Ngoc, Fiegel, Vincent, Blain, Guillaume, Chiavassa, Sophie, Craff, Emeline, Delpon, Grégory, Evin, Manon, Haddad, Ferid, Incerti, Sébastien, Koumeir, Charbel, Métivier, Vincent, Mouchard, Quentin, Poirier, Freddy, Potiron, Vincent, Servagent, Noël, Vandenborre, Johan, and Maigne, Lydia

Subjects
REACTIVE oxygen species, IONIZATION chambers, MONTE Carlo method, DEPTH profiling, RADIOLYSIS, PROTON beams
Abstract

Background: Radiobiological effectiveness of radiation in cancer treatment can be studied at different scales (molecular till organ scale) and different time post irradiation. The production of free radicals and reactive oxygen species during water radiolysis is particularly relevant to understand the fundamental mechanisms playing a role in observed biological outcomes. The development and validation of Monte Carlo tools integrating the simulation of physical, physico‐chemical and chemical stages after radiation is very important to maintain with experiments. Purpose: Therefore, in this study, we propose to validate a new Geant4‐DNA chemistry module through the simulation of water radiolysis and Fricke dosimetry experiments on a proton preclinical beam line. Material and methods: In this study, we used the GATE Monte Carlo simulation platform (version 9.3) to simulate a 67.5 MeV proton beam produced with the ARRONAX isochronous cyclotron (IBA Cyclone 70XP) at conventional dose rate (0.2 Gy/s) to simulate the irradiation of ultra‐pure liquid water samples and Fricke dosimeter. We compared the depth dose profile with measurements performed with a plane parallel Advanced PTW 34045 Markus ionization chamber. Then, a new Geant4‐DNA chemistry application proposed from Geant4 version 11.2 has been used to assess the evolution of HO•${\mathrm{HO}}^ \bullet $, eaq−${\mathrm{e}}_{{\mathrm{aq}}}^ - $, H3O+${{\mathrm{H}}}_3{{\mathrm{O}}}^ + $, H2O2${{\mathrm{H}}}_2{{\mathrm{O}}}_2$, H2${{\mathrm{H}}}_2$, HO2•${\mathrm{HO}}_2^ \bullet $, HO2−,O2•−${\mathrm{HO}}_2^ - ,{\mathrm{\ O}}_2^{ \bullet - }$ and HO−${\mathrm{HO}}^ - $ reactive species along time until 1‐h post‐irradiation. In particular, the effect of oxygen and pH has been investigated through comparisons with experimental measurements of radiolytic yields for H2O2${{\mathrm{H}}}_2{{\mathrm{O}}}_2$ and Fe3+. Results: GATE simulations reproduced, within 4%, the depth dose profile in liquid water. With Geant4‐DNA, we were able to reproduce experimental H2O2${{\mathrm{H}}}_2{{\mathrm{O}}}_2$ radiolytic yields 1‐h post‐irradiation in aerated and deaerated conditions, showing the impact of small changes in oxygen concentrations on species evolution along time. For the Fricke dosimeter, simulated G(Fe3+) is 15.97 ± 0.2 molecules/100 eV which is 11% higher than the measured value (14.4 ± 04 molecules/100 eV). Conclusions: These results aim to be consolidated by new comparisons involving other radiolytic species, such as eaq−${\mathrm{e}}_{{\mathrm{aq}}}^ - $ or ,O2•−$,{\mathrm{\ O}}_2^{ \bullet - }$ to further study the mechanisms underlying the FLASH effect observed at ultra‐high dose rates (UHDR). [ABSTRACT FROM AUTHOR]

Published
2024
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7. First evidence of in vivo effect of FLASH radiotherapy with helium ions in zebrafish embryos

Author

Ghannam, Youssef, primary, Chiavassa, Sophie, additional, Saade, Gaëlle, additional, Koumeir, Charbel, additional, Blain, Guillaume, additional, Delpon, Grégory, additional, Evin, Manon, additional, Haddad, Ferid, additional, Maigne, Lydia, additional, Mouchard, Quentin, additional, Servagent, Noël, additional, Potiron, Vincent, additional, and Supiot, Stéphane, additional

Published
2023
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10. Hydrogen Peroxide (H2O2) production in response to multiple beam irradiation of protons at UHDR

Author

Evin, Manon, Fiegel, Vincent, Delpon, Grégory, Mouchard, Quentin, Emeline, Craff, Haddad, Ferid, Koumeir, Charbel, Maigne, Lydia, Métivier, Vincent, Potiron, Vincent, Servagent, Noël, Supiot, Stéphane, Vandenborre, Johan, Blain, Guillaume, Chiavassa, Sophie, Laboratoire de physique subatomique et des technologies associées (SUBATECH), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-IMT Atlantique (IMT Atlantique), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT)-Nantes université - UFR des Sciences et des Techniques (Nantes univ - UFR ST), Nantes Université - pôle Sciences et technologie, Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ)-Nantes Université - pôle Sciences et technologie, Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ), Institut de Cancérologie de l'Ouest [Angers/Nantes] (UNICANCER/ICO), UNICANCER, GIP ARRONAX [Nantes], Université de Nantes (UN), Laboratoire de Physique de Clermont (LPC), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Université Clermont Auvergne (UCA), Unité en Sciences Biologiques et Biotechnologies de Nantes (US2B), Centre National de la Recherche Scientifique (CNRS)-Nantes Université - UFR de Médecine et des Techniques Médicales (Nantes Univ - UFR MEDECINE), Nantes Université - pôle Santé, Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ)-Nantes Université - pôle Santé, and FLASHMOD

Subjects
FLASHMOD project, Radiochemistry, FLASH effect mecanisms, [SDV.CAN]Life Sciences [q-bio]/Cancer, External beam therapy, [PHYS.NEXP]Physics [physics]/Nuclear Experiment [nucl-ex], [CHIM.RADIO]Chemical Sciences/Radiochemistry
Abstract

International audience

Published
2023

11. Supplementary Figure 3 from Secretion of Acid Sphingomyelinase and Ceramide by Endothelial Cells Contributes to Radiation-Induced Intestinal Toxicity

Author

Leonetti, Daniela, primary, Estéphan, Hala, primary, Ripoche, Natacha, primary, Dubois, Nolwenn, primary, Aguesse, Audrey, primary, Gouard, Sébastien, primary, Brossard, Lisa, primary, Chiavassa, Sophie, primary, Corre, Isabelle, primary, Pecqueur, Claire, primary, Neunlist, Michel, primary, Hadchity, Elie, primary, Gaugler, Marie-Hélène, primary, Mahé, Maxime M., primary, and Paris, François, primary

Published
2023
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12. Data from Secretion of Acid Sphingomyelinase and Ceramide by Endothelial Cells Contributes to Radiation-Induced Intestinal Toxicity

Author

Leonetti, Daniela, primary, Estéphan, Hala, primary, Ripoche, Natacha, primary, Dubois, Nolwenn, primary, Aguesse, Audrey, primary, Gouard, Sébastien, primary, Brossard, Lisa, primary, Chiavassa, Sophie, primary, Corre, Isabelle, primary, Pecqueur, Claire, primary, Neunlist, Michel, primary, Hadchity, Elie, primary, Gaugler, Marie-Hélène, primary, Mahé, Maxime M., primary, and Paris, François, primary

Published
2023
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13. Supplementary Figure 7 from Secretion of Acid Sphingomyelinase and Ceramide by Endothelial Cells Contributes to Radiation-Induced Intestinal Toxicity

Author

Leonetti, Daniela, primary, Estéphan, Hala, primary, Ripoche, Natacha, primary, Dubois, Nolwenn, primary, Aguesse, Audrey, primary, Gouard, Sébastien, primary, Brossard, Lisa, primary, Chiavassa, Sophie, primary, Corre, Isabelle, primary, Pecqueur, Claire, primary, Neunlist, Michel, primary, Hadchity, Elie, primary, Gaugler, Marie-Hélène, primary, Mahé, Maxime M., primary, and Paris, François, primary

Published
2023
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14. Supplementary Figure 1 from Secretion of Acid Sphingomyelinase and Ceramide by Endothelial Cells Contributes to Radiation-Induced Intestinal Toxicity

Author

Leonetti, Daniela, primary, Estéphan, Hala, primary, Ripoche, Natacha, primary, Dubois, Nolwenn, primary, Aguesse, Audrey, primary, Gouard, Sébastien, primary, Brossard, Lisa, primary, Chiavassa, Sophie, primary, Corre, Isabelle, primary, Pecqueur, Claire, primary, Neunlist, Michel, primary, Hadchity, Elie, primary, Gaugler, Marie-Hélène, primary, Mahé, Maxime M., primary, and Paris, François, primary

Published
2023
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15. Supplementary Figure 2 from Secretion of Acid Sphingomyelinase and Ceramide by Endothelial Cells Contributes to Radiation-Induced Intestinal Toxicity

Author

Leonetti, Daniela, primary, Estéphan, Hala, primary, Ripoche, Natacha, primary, Dubois, Nolwenn, primary, Aguesse, Audrey, primary, Gouard, Sébastien, primary, Brossard, Lisa, primary, Chiavassa, Sophie, primary, Corre, Isabelle, primary, Pecqueur, Claire, primary, Neunlist, Michel, primary, Hadchity, Elie, primary, Gaugler, Marie-Hélène, primary, Mahé, Maxime M., primary, and Paris, François, primary

Published
2023
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16. Supplementary Figure 4 from Secretion of Acid Sphingomyelinase and Ceramide by Endothelial Cells Contributes to Radiation-Induced Intestinal Toxicity

Author

Leonetti, Daniela, primary, Estéphan, Hala, primary, Ripoche, Natacha, primary, Dubois, Nolwenn, primary, Aguesse, Audrey, primary, Gouard, Sébastien, primary, Brossard, Lisa, primary, Chiavassa, Sophie, primary, Corre, Isabelle, primary, Pecqueur, Claire, primary, Neunlist, Michel, primary, Hadchity, Elie, primary, Gaugler, Marie-Hélène, primary, Mahé, Maxime M., primary, and Paris, François, primary

Published
2023
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17. Supplementary Figure 5 from Secretion of Acid Sphingomyelinase and Ceramide by Endothelial Cells Contributes to Radiation-Induced Intestinal Toxicity

Author

Leonetti, Daniela, primary, Estéphan, Hala, primary, Ripoche, Natacha, primary, Dubois, Nolwenn, primary, Aguesse, Audrey, primary, Gouard, Sébastien, primary, Brossard, Lisa, primary, Chiavassa, Sophie, primary, Corre, Isabelle, primary, Pecqueur, Claire, primary, Neunlist, Michel, primary, Hadchity, Elie, primary, Gaugler, Marie-Hélène, primary, Mahé, Maxime M., primary, and Paris, François, primary

Published
2023
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18. Supplementary Figure 6 from Secretion of Acid Sphingomyelinase and Ceramide by Endothelial Cells Contributes to Radiation-Induced Intestinal Toxicity

Author

Leonetti, Daniela, primary, Estéphan, Hala, primary, Ripoche, Natacha, primary, Dubois, Nolwenn, primary, Aguesse, Audrey, primary, Gouard, Sébastien, primary, Brossard, Lisa, primary, Chiavassa, Sophie, primary, Corre, Isabelle, primary, Pecqueur, Claire, primary, Neunlist, Michel, primary, Hadchity, Elie, primary, Gaugler, Marie-Hélène, primary, Mahé, Maxime M., primary, and Paris, François, primary

Published
2023
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19. Ultrahigh-Dose-Rate Proton Irradiation Elicits Reduced Toxicity in Zebrafish Embryos

Author

Saade, Gaëlle, primary, Bogaerts, Eva, additional, Chiavassa, Sophie, additional, Blain, Guillaume, additional, Delpon, Grégory, additional, Evin, Manon, additional, Ghannam, Youssef, additional, Haddad, Ferid, additional, Haustermans, Karin, additional, Koumeir, Charbel, additional, Macaeva, Ellina, additional, Maigne, Lydia, additional, Mouchard, Quentin, additional, Servagent, Noël, additional, Sterpin, Edmond, additional, Supiot, Stéphane, additional, and Potiron, Vincent, additional

Published
2023
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20. Reduction of radiotoxicity by ultra-high dose rate protontherapy

Author

Saade, Gaëlle, Bogaerts, Eva, Chiavassa, Sophie, Blain, Guillaume, Delpon, Grégory, Evin, Manon, Ghannam, Youssef, Haddad, Ferid, Haustermans, Karin, Koumeir, Charbel, Macaeva, Ellina, Maigne, Lydia, Mouchard, Quentin, Servagent, Noël, Sterpin, Edmond, Supiot, Stéphane, Potiron, Vincent, Unité en Sciences Biologiques et Biotechnologies de Nantes (US2B), Centre National de la Recherche Scientifique (CNRS)-Nantes Université - UFR de Médecine et des Techniques Médicales (Nantes Univ - UFR MEDECINE), Nantes Université - pôle Santé, Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ)-Nantes Université - pôle Santé, Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ), Department of Oncology [Leuven, Belgium], Catholic University of Leuven - Katholieke Universiteit Leuven (KU Leuven), Institut de Cancérologie de l'Ouest [Angers/Nantes] (UNICANCER/ICO), UNICANCER, Laboratoire de physique subatomique et des technologies associées (SUBATECH), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-IMT Atlantique (IMT Atlantique), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT)-Nantes université - UFR des Sciences et des Techniques (Nantes univ - UFR ST), Nantes Université - pôle Sciences et technologie, Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ)-Nantes Université - pôle Sciences et technologie, GIP ARRONAX [Nantes], Université de Nantes (UN), University Hospitals Leuven [Leuven], Institut de Recherche Expérimentale et Clinique (IREC), Université Catholique de Louvain = Catholic University of Louvain (UCL), Laboratoire de Physique de Clermont (LPC), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Université Clermont Auvergne (UCA), Financial support from Inserm Cancer (PCSI FLASHMOD), Karen Kirkby, Marie-Catherine Vozenin, Núria Jornet Sala, Stephanie E. Combs, FLASHMOD, ANR-11-EQPX-0004,ARRONAXPLUS,Nucléaire pour la Santé(2011), and ANR-16-IDEX-0007,NExT (I-SITE),NExT (I-SITE)(2016)

Subjects
Protontherapy, [SDV]Life Sciences [q-bio], [SDV.CAN]Life Sciences [q-bio]/Cancer, Ultra-high dose rate
Abstract

International audience

Published
2022

21. Radiolytic ROS production mechanism under proton flash conditions : combination of experimental and simulation investigation

Author

Fiegel, Vincent, Fois, Giovanna Rosa, Blain, Guillaume, Evin, Manon, Mouchard, Quentin, Koumeir, Charbel, Servagent, Noël, Emeline, Craff, Ghalei, Mohammad, Métivier, Vincent, Poirier, Freddy, Potiron, Vincent, Supiot, Stéphane, Haddad, Ferid, Delpon, Grégory, Vandenborre, Johan, Maigne, Lydia, Chiavassa, Sophie, Institut de Cancérologie de l'Ouest [Angers/Nantes] (UNICANCER/ICO), UNICANCER, GIP ARRONAX [Nantes], Université de Nantes (UN), Laboratoire de physique subatomique et des technologies associées (SUBATECH), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-IMT Atlantique (IMT Atlantique), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT)-Nantes université - UFR des Sciences et des Techniques (Nantes univ - UFR ST), Nantes Université - pôle Sciences et technologie, Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ)-Nantes Université - pôle Sciences et technologie, Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ), Laboratoire de Physique de Clermont (LPC), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Université Clermont Auvergne (UCA), Unité en Sciences Biologiques et Biotechnologies de Nantes (US2B), Centre National de la Recherche Scientifique (CNRS)-Nantes Université - UFR de Médecine et des Techniques Médicales (Nantes Univ - UFR MEDECINE), Nantes Université - pôle Santé, Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ)-Nantes Université - pôle Santé, Financial support from Inserm Cancer (PCSI FLASHMOD), Karen Kirkby, Marie-Catherine Vozenin, Núria Jornet Sala, Stephanie E. Combs, FLASHMOD, ANR-11-EQPX-0004,ARRONAXPLUS,Nucléaire pour la Santé(2011), ANR-16-IDEX-0007,NExT (I-SITE),NExT (I-SITE)(2016), and ANR-11-LABX-0018,IRON,Radiopharmaceutiques Innovants en Oncologie et Neurologie(2011)

Subjects
radiolytic ros, experimental, [SDV.CAN]Life Sciences [q-bio]/Cancer, [PHYS.NEXP]Physics [physics]/Nuclear Experiment [nucl-ex], flash therapy, Ultra-high dose rate, simulation, [CHIM.RADIO]Chemical Sciences/Radiochemistry, proton
Abstract

International audience

Published
2022

22. Pyruvate carboxylation identifies Glioblastoma Stem-like Cells opening new metabolic strategy to prevent tumor recurrence

Author

Renoult, Ophélie, primary, Gratas, Catherine, additional, Joalland, Noémie, additional, Laurent--Blond, Mélanie, additional, Awada, Hala, additional, Bourgeois, Marine, additional, Oliver, Lisa, additional, Chiavassa, Sophie, additional, Croyal, Mikaël, additional, Paris, François, additional, and Pecqueur, Claire, additional

Published
2022
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24. Proton Irradiations at Ultra-High Dose Rate vs. Conventional Dose Rate: Strong Impact on Hydrogen Peroxide Yield

Author

Blain, Guillaume, primary, Vandenborre, Johan, additional, Villoing, Daphnée, additional, Fiegel, Vincent, additional, Fois, Giovanna Rosa, additional, Haddad, Ferid, additional, Koumeir, Charbel, additional, Maigne, Lydia, additional, Métivier, Vincent, additional, Poirier, Freddy, additional, Potiron, Vincent, additional, Supiot, Stéphane, additional, Servagent, Noël, additional, Delpon, Grégory, additional, and Chiavassa, Sophie, additional

Published
2022
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25. Réduction de la radiotoxicité par hadronthérapie à ultra-haut débit de dose

Author

Saade, Gaëlle, Chiavassa, Sophie, Koumeir, Charbel, Delpon, Grégory, Evin, Manon, Ghannam, Youssef, Haddad, Ferid, Servagent, Noël, Supiot, Stéphane, Potiron, Vincent, Mouchard, Quentin, Nucléaire pour la Santé - - ARRONAXPLUS2011 - ANR-11-EQPX-0004 - EQPX - VALID, and NExT (I-SITE) - - NExT (I-SITE)2016 - ANR-16-IDEX-0007 - IDEX - VALID

Subjects
[SDV.CAN] Life Sciences [q-bio]/Cancer, ULTRA-HIGH DOSE RATE, RADIOTHERAPY
Published
2022

26. Technical note: Proton beam dosimetry at ultra‐high dose rates (FLASH): Evaluation of GAFchromic™ (EBT3, EBT‐XD) and OrthoChromic (OC‐1) film performances

Author

Villoing, Daphnée, primary, Koumeir, Charbel, additional, Bongrand, Arthur, additional, Guertin, Arnaud, additional, Haddad, Ferid, additional, Métivier, Vincent, additional, Poirier, Freddy, additional, Potiron, Vincent, additional, Servagent, Noël, additional, Supiot, Stéphane, additional, Delpon, Grégory, additional, and Chiavassa, Sophie, additional

Published
2022
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27. UHDR proton beam vs conventional: hydrogen peroxide as FLASH effect sensor

Author

Blain, Guillaume, Vandenborre, Johan, Villoing, Daphnée, Bongrand, A., Fois, Giovanna Rosa, Guertin, Arnaud, Haddad, Ferid, Hotoiu, Lucian, Labarbe, Rudi, Maigne, Lydia, Métivier, Vincent, Poirier, Freddy, Servagent, Noël, Supiot, Stéphane, Delpon, Grégory, Chiavassa, Sophie, Laboratoire de physique subatomique et des technologies associées (SUBATECH), Université de Nantes - UFR des Sciences et des Techniques (UN UFR ST), Université de Nantes (UN)-Université de Nantes (UN)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-IMT Atlantique (IMT Atlantique), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT), Institut de Cancérologie de l'Ouest [Angers/Nantes] (UNICANCER/ICO), UNICANCER, GIP ARRONAX [Nantes], Université de Nantes (UN), Laboratoire de Physique de Clermont (LPC), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Université Clermont Auvergne (UCA), Ion Beam Applications SA [Louvain-La-Neuve, Belgium], IBA, Unité en Sciences Biologiques et Biotechnologies de Nantes (US2B), Centre National de la Recherche Scientifique (CNRS)-Nantes Université - UFR de Médecine et des Techniques Médicales (Nantes Univ - UFR MEDECINE), Nantes Université - pôle Santé, Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ)-Nantes Université - pôle Santé, Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-IMT Atlantique (IMT Atlantique), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT)-Nantes université - UFR des Sciences et des Techniques (Nantes univ - UFR ST), Nantes Université - pôle Sciences et technologie, Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ)-Nantes Université - pôle Sciences et technologie, Financial support from Inserm Cancer (PCSI FLASHMOD), Marie Dutreix, Karen Kirkby, Andreas Schüller, Marie-Catherine Vozenin, FLASHMOD, ANR-11-EQPX-0004,ARRONAXPLUS,Nucléaire pour la Santé(2011), and ANR-16-IDEX-0007,NExT (I-SITE),NExT (I-SITE)(2016)

Subjects
[SDV.CAN]Life Sciences [q-bio]/Cancer, [PHYS.NEXP]Physics [physics]/Nuclear Experiment [nucl-ex], [CHIM.RADIO]Chemical Sciences/Radiochemistry
Abstract

International audience

Published
2021

28. Voluntary Wheel Running Does Not Enhance Radiotherapy Efficiency in a Preclinical Model of Prostate Cancer: The Importance of Physical Activity Modalities?

Author

Dufresne, Suzanne, primary, Richard, Cindy, additional, Dieumegard, Arthur, additional, Orfila, Luz, additional, Delpon, Gregory, additional, Chiavassa, Sophie, additional, Martin, Brice, additional, Rouvière, Laurent, additional, Escoffre, Jean-Michel, additional, Oujagir, Edward, additional, Denis de Senneville, Baudouin, additional, Bouakaz, Ayache, additional, Rioux-Leclercq, Nathalie, additional, Potiron, Vincent, additional, and Rébillard, Amélie, additional

Published
2021
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29. A Monte Carlo Determination of Dose and Range Uncertainties for Preclinical Studies with a Proton Beam

Author

Bongrand, Arthur, primary, Koumeir, Charbel, additional, Villoing, Daphnée, additional, Guertin, Arnaud, additional, Haddad, Ferid, additional, Métivier, Vincent, additional, Poirier, Freddy, additional, Potiron, Vincent, additional, Servagent, Noël, additional, Supiot, Stéphane, additional, Delpon, Grégory, additional, and Chiavassa, Sophie, additional

Published
2021
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30. Secretion of Acid Sphingomyelinase and Ceramide by Endothelial Cells Contributes to Radiation-Induced Intestinal Toxicity

Author

Leonetti, Daniela, primary, Estéphan, Hala, additional, Ripoche, Natacha, additional, Dubois, Nolwenn, additional, Aguesse, Audrey, additional, Gouard, Sébastien, additional, Brossard, Lisa, additional, Chiavassa, Sophie, additional, Corre, Isabelle, additional, Pecqueur, Claire, additional, Neunlist, Michel, additional, Hadchity, Elie, additional, Gaugler, Marie-Hélène, additional, Mahé, Maxime M., additional, and Paris, François, additional

Published
2020
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33. The Injection and Chopper-Based System at Arronax C70XP Cyclotron

Author

Poirier, Freddy, Blain, Guillaume, Bulteau-Harel, Francois, Chiavassa, Sophie, Delpon, Gregory, Durand, Teddy, Fattahi, Massoud, Goiziou, Xavier, Haddad, Ferid, Koumeir, Charbel, Sengar, Atul, Trichet, Herve, Vandenborre, Johan, Cyclotron ARRONAX, GIP, Laboratoire de physique subatomique et des technologies associées (SUBATECH), Université de Nantes - UFR des Sciences et des Techniques (UN UFR ST), Université de Nantes (UN)-Université de Nantes (UN)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-IMT Atlantique Bretagne-Pays de la Loire (IMT Atlantique), and Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT)

Subjects
solenoid, injection, experiment, 04 Operation and Upgrades, [PHYS.PHYS.PHYS-ACC-PH]Physics [physics]/Physics [physics]/Accelerator Physics [physics.acc-ph], cyclotron, simulation, Accelerator Physics
Abstract

The multi-particle cyclotron of the Arronax Public Interest Group (GIP) is used to perform irradiation up to hundreds of µA on various experiments and targets. To support low and high average intensity usage and adapt the beam time structure required for high peak intensity operation and experiments such as pulsed experiments studies, it has been devised a pulsing system in the injection of the cyclotron. This system combines the use of a chopper, low frequency switch, and a control system based on the new extended EPICS network. This paper details the pulsing system adopted at Arronax, updates and results for various intensity experimental studies performed with alpha and proton beams. Updated work on the simulation of the injection is also shown, specifically towards high intensity future irradiation., Proceedings of the 22nd International Conference on Cyclotrons and their Applications, Cyclotrons2019, Cape Town, South Africa

Published
2019
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34. Could exercise training alter radiotherapy efficiency in a murine model of prostate cancer?

Author

Dufresne, Suzanne, Gueritat, Jordan, Chiavassa, Sophie, Noblet, Caroline, Assi, Mohamad, Rannou-Bekono, Françoise, Orfila, Luz, Paris, François, Rébillard, Amélie, Laboratoire Mouvement Sport Santé (M2S), École normale supérieure - Cachan (ENS Cachan)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Université de Brest (UBO)-Université de Rennes 2 (UR2), Université de Rennes (UNIV-RENNES)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Endothelium Radiobiology and Targeting (CRCINA-ÉQUIPE 14), Centre de Recherche en Cancérologie et Immunologie Nantes-Angers (CRCINA), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), Université de Nantes (UN)-Université de Nantes (UN)-Centre hospitalier universitaire de Nantes (CHU Nantes)-Centre National de la Recherche Scientifique (CNRS)-Université d'Angers (UA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), Université de Nantes (UN)-Université de Nantes (UN)-Centre hospitalier universitaire de Nantes (CHU Nantes)-Centre National de la Recherche Scientifique (CNRS)-Université d'Angers (UA), Université de Rennes (UR)-École normale supérieure - Rennes (ENS Rennes)-Université de Brest (UBO)-Université de Rennes 2 (UR2)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), and Université d'Angers (UA)-Université de Nantes (UN)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Centre hospitalier universitaire de Nantes (CHU Nantes)-Université d'Angers (UA)-Université de Nantes (UN)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Centre hospitalier universitaire de Nantes (CHU Nantes)

Subjects
[SDV]Life Sciences [q-bio], ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2019

38. DEMAT: A multi-institutional dosimetry audit of rotational and static intensity-modulated radiotherapy

Author

Lafond, Caroline, primary, Chiavassa, Sophie, additional, Bertaut, Cindy, additional, Boussion, Nicolas, additional, Chapel, Nathalie, additional, Chapron, Lucie, additional, Coste, Frédéric, additional, Crespin, Sylvain, additional, Dy, Gilles, additional, Faye, Papa Abdoulaye, additional, Leleu, Cyril, additional, Bouvier, Jeanne, additional, Madec, Ludovic, additional, Mesgouez, Jérôme, additional, Palisson, Jérémy, additional, Vela, Anthony, additional, and Delpon, Grégory, additional

Published
2016
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45. Tomography of cool giant and supergiant star atmospheres: III. Validation of the method on VLTI/AMBER observations of the Mira star S Ori.

Author

Kravchenko, Kateryna, Wittkowski, Markus, Jorissen, Alain, Chiavassa, Andrea, Van Eck, Sophie, Anderson, Richard I., Freytag, Bernd, and Käufl, Ulli

Subjects
STELLAR atmospheres, GIANT stars, STAR observations, ASYMPTOTIC giant branch stars, ATMOSPHERIC layers, SUPERGIANT stars
Abstract

Context. Asymptotic giant branch (AGB) stars are characterized by substantial mass loss, however the mechanism behind it not yet fully understood. The knowledge of the structure and dynamics of AGB-star atmospheres is crucial to better understanding the mass loss. The recently established tomographic method, which relies on the design of spectral masks containing lines that form in given ranges of optical depths in the stellar atmosphere, is an ideal technique for this purpose. Aims. We aim to validate the capability of the tomographic method in probing different geometrical depths in the stellar atmosphere and recovering the relation between optical and geometrical depth scales. Methods. We applied the tomographic method to high-resolution spectro-interferometric VLTI/AMBER observations of the Mira-type AGB star S Ori. The interferometric visibilities were extracted at wavelengths contributing to the tomographic masks and fitted to those computed from a uniform disk model. This allows us to measure the geometrical extent of the atmospheric layer probed by the corresponding mask. We then compared the observed atmospheric extension with others measured from available 1D pulsation CODEX models and 3D radiative-hydrodynamics CO5BOLD simulations. Results. While the average optical depths probed by the tomographic masks in S Ori decrease (with ⟨log τ0⟩ = −0.45, − 1.45, and − 2.45 from the innermost to the central and outermost layers), the angular diameters of these layers increase, from 10.59 ± 0.09 mas through 11.84 ± 0.17 mas, up to 14.08 ± 0.15 mas. A similar behavior is observed when the tomographic method is applied to 1D and 3D dynamical models. Conclusions. This study derives, for the first time, a quantitative relation between optical and geometrical depth scales when applied to the Mira star S Ori, or to 1D and 3D dynamical models. In the context of Mira-type stars, knowledge of the link between the optical and geometrical depths opens the way to deriving the shock-wave propagation velocity, which cannot be directly observed in these stars. [ABSTRACT FROM AUTHOR]

Published
2020
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