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Current-voltage measurement (I–V curve) is a typical method to identify the critical current (Ic) of second-generation high-temperature superconducting tapes (2G HTS tapes). However, it is difficult to characterize the local Ic of 2G HTS tape on the millimeter (mm) scale due to the set spacing of the voltage electrodes (several centimeters), so non-contact trapped field distribution measurements have been used to define local defects in Y–Ba–Cu–O bulks and 2G HTS tapes, especially for the quality analysis for long lengths of 2G HTS tapes. In order to discuss the possible degradation of 2G HTS tape during heating and bending (both important parameters in joining process), this study used both trapped field measurement and I–V measurement to characterize the effect of heating (190 °C–230 °C) and bending (radius = 3.75 mm–22.35 mm) processes on the degradation of 2G HTS tape Ic. In addition, according to electromagnetic calculations, the local Ic (within a few millimeters) of the 2G HTS tape can be obtained from the flux density and distribution of the trapped magnetic field. Comparing the two sets of Ic measurements showed very good agreement. This study demonstrates the accuracy of optimized heating and bending parameters as well as spatial position and local Ic values of processed 2G HTS tape through non-contact trapped field measurements.

In corporate social responsibility (CSR) research conducted in micro, small and medium-sized enterprises (SMEs), the relationship between organizational-level CSR and individual-level outcomes is receiving increasing research attention. However, little is known about why, when, and how CSR would encourage employees to engage in unethical pro-organizational behaviors (UPB). Combining attribution theory with cue consistency theory, this study develops a mediated moderation model to explore the mechanism and boundary condition underlying the effect of external CSR, an organizational factor, on employees' UPB. Data were collected from 304 employees working in 10 SMEs in China at two-time points. The results showed that external CSR had a positive effect on UPB through symbolic attribution, while perceived internal CSR weakened the positive effect of external CSR on UPB as well as the indirect effect of symbolic attribution in the relationship between external CSR and UPB. Overall, this study explains why, when, and how external CSR facilitates employees' UPB. These findings indicate attribution to be the very mechanism that explains employees' behavioral response to the organization's external CSR and provide an innovative insight into how internal CSR may be utilized to reduce UPB of employees of Chinese SMEs., Author(s): Xu Wang [sup.1] [sup.2] [sup.3] , Changchun Xiang [sup.2] , Liang Meng [sup.1] [sup.3] , Lei Chi [sup.4] , Songpu Li [sup.2] Author Affiliations: (1) grid.412515.6, 0000 0001 1702 [...]

The long-term heating (>60 min) of second generation high temperature superconductor (2G HTS) tape-joints at temperatures above 200 °C leads to the continuous deterioration of their superconducting properties. Previously, we proposed a resistive Joule heating process with a short heating time (∼10 min) that exhibited beneficial critical current (Ic), retention percentages (84–99 %), and joint resistances (74–697 nΩ cm2) in four independent experiments.In this study, we investigated two heating rates and three tape-joint areas. The results show that for the samples with different tape joint areas, the critical current retention percentages (97–100 %) and uniformity of specific joint resistances (82–272 nΩ cm2) were significantly improved at a high heating rate of ∼30 °C/min. The sintering of silver nanoparticles and oxidation characteristics of the copper stabilizers were observed using transmission electron microscopy, scanning electron microscopy, and Raman spectroscopy to elucidate the effect of different heating profiles. This study opens new avenues for improving the quality of 2G HTS tape joint processes for ultrahigh magnetic field applications.

AimsOur aim was to differentiate patients with mild cognitive impairment (MCI) and Alzheimer’s disease (AD) from cognitively normal (CN) individuals and predict the progression from MCI to AD within a 3-year longitudinal follow-up. A newly developed Holo-Hilbert Spectral Analysis (HHSA) was applied to resting state EEG (rsEEG), and features were extracted and subjected to machine learning algorithms.MethodsA total of 205 participants were recruited from three hospitals, with CN (n = 51, MMSE > 26), MCI (n = 42, CDR = 0.5, MMSE ≥ 25), AD1 (n = 61, CDR = 1, MMSE < 25), AD2 (n = 35, CDR = 2, MMSE < 16), and AD3 (n = 16, CDR = 3, MMSE < 16). rsEEG was also acquired from all subjects. Seventy-two MCI patients (CDR = 0.5) were longitudinally followed up with two rsEEG recordings within 3 years and further subdivided into an MCI-stable group (MCI-S, n = 36) and an MCI-converted group (MCI-C, n = 36). The HHSA was then applied to the rsEEG data, and features were extracted and subjected to machine-learning algorithms.Results(a) At the group level analysis, the HHSA contrast of MCI and different stages of AD showed augmented amplitude modulation (AM) power of lower-frequency oscillations (LFO; delta and theta bands) with attenuated AM power of higher-frequency oscillations (HFO; beta and gamma bands) compared with cognitively normal elderly controls. The alpha frequency oscillation showed augmented AM power across MCI to AD1 with a reverse trend at AD2. (b) At the individual level of cross-sectional analysis, implementation of machine learning algorithms discriminated between groups with good sensitivity (Sen) and specificity (Spec) as follows: CN elderly vs. MCI: 0.82 (Sen)/0.80 (Spec), CN vs. AD1: 0.94 (Sen)/0.80 (Spec), CN vs. AD2: 0.93 (Sen)/0.90 (Spec), and CN vs. AD3: 0.75 (Sen)/1.00 (Spec). (c) In the longitudinal MCI follow-up, the initial contrasted HHSA between MCI-S and MCI-C groups showed significantly attenuated AM power of alpha and beta band oscillations. (d) At the individual level analysis of longitudinal MCI groups, deploying machine learning algorithms with the best seven features resulted in a sensitivity of 0.9 by the support vector machine (SVM) classifier, with a specificity of 0.8 yielded by the decision tree classifier.ConclusionIntegrating HHSA into EEG signals and machine learning algorithms can differentiate between CN and MCI as well as also predict AD progression at the MCI stage.

The involvement of Loose Plant Architecture 1 (LPA1) in regulating plant growth and leaf angle has been previously demonstrated. However, the fundamental genetic background remains unidentified. To further understand the tissue expression profile of the NtLPA1 gene, an overexpression vector (pBI121-NtLPA1) was developed and employed to modify tobacco using the leaf disc method genetically. Validation confirmed the generation of transgenic tobacco plants with NtLPA1 overexpression. The findings indicated that increased NtLPA1 overexpression substantially decreased plant auxin sensitivity and modulated signal transduction and polar transport, significantly reducing leaf angle, diminished leaf area during early and late growth stages, and shortened root length. In summary, NtLPA1 augmented tobacco resistance to severe shin disease by modulating the expression of disease-associated genes PBZ1, PR1b, and the growth regulator auxin polar transport factor PIN1. [ABSTRACT FROM AUTHOR]

At present, the influence of time-harmonic currents on the leakage flux coefficient of canned permanent magnet synchronous motors (CPMSMs) remains unclear. Therefore, this paper investigates and summarizes the effects of inverter time-harmonic currents on the leakage flux coefficient of the CPMSM. A 1.5 kW, 9000 RPM (Revolutions Per Minute) CPMSM is used as the research subject. Based on a finite element model, the leakage flux coefficients under sinusoidal and non-sinusoidal supply conditions are calculated using the magnetic flux density integration method. Additionally, the study examines changes in the leakage flux coefficient under different harmonic orders and amplitudes. The results indicate that the introduction of fifth and seventh time-harmonic currents by the inverter reduces the leakage flux coefficient, which helps to improve the utilization of the permanent magnets. This research significantly contributes to enriching the theory of inverter-fed permanent magnet motors. [ABSTRACT FROM AUTHOR]

The J-TEXT capability is enhanced compared to two years ago with several upgrades of its diagnostics and the increase of electron cyclotron resonance heating (ECRH) power to 1 MW. With the application of electron cyclotron wave (ECW), the ECW assisted plasma startup is achieved; the tearing mode is suppressed; the toroidal injection of 300 kW ECW drives around 24 kA current; fast electrons are generated with toroidal injected ECW and the runaway current conversion efficiency increases with ECRH power. The mode coupling between 2/1 and 3/1 modes are extensively studied. The coupled 2/1 and 3/1 modes usually lead to major disruption. Their coupling can be either suppressed or avoided by external resonant magnetic perturbation fields and hence avoids the major disruption. It is also found that the 2/1 threshold of external field is significantly reduced by a pre-excited 3/1 mode, which can be either a locked island or an external kink mode. The disruption control is studied by developing prediction methods capable of cross tokamak application and by new mitigation methods, such as the biased electrode or electromagnetic pellet injector. The high-density operation and related disruptions are studied from various aspects. Approaching the density limit, the collapse of the edge shear layer is observed and such collapse can be prevented by applying edge biasing, leading to an increased density limit. The density limit is also observed to increase, if the plasma is operated in the poloidal divertor configuration or the plasma purity is increased by increasing the pre-filled gas pressure or ECRH power during the start-up phase.

Abstract. Background:. There is growing evidence that 5-fluorouracil (5-FU) combined with therapeutic trauma can effectively induce skin repigmentation in vitiligo patients who are unresponsive to conventional treatments. Previous studies have mainly focused on identifying the antimitotic activity of 5-FU for the treatment of skin cancer, but few studies have investigated its extra-genotoxic actions favoring melanocyte recruitment. Methods:. We utilized the full thickness excisional skin wound model in Dct-LacZ transgenic mice to dynamically assess the migration of melanocytes in the margins of wounds treated with or without 5-FU. The in-situ expression of CXCL12 was examined in the wound beds using immunofluorescence staining. Quantitative real-time polymerase chain reaction and Western blotting analyses were performed to detect the expression levels of CXCL12 mRNA and protein in primary mouse dermal fibroblasts treated with or without 5-FU. Transwell assays and fluorescein isothiocyanate (FITC)-phalloidin staining were used to observe cell migration and filamentous actin (F-actin) changes of melan-a murine melanocytes. Results:. Whole mount and cryosection X-gal staining showed that the cell numbers of LacZ-positive melanocytes were much higher in the margins of dorsal and tail skin wounds treated with 5-FU compared with the controls. Meanwhile, CXCL12 immunostaining was significantly increased in the dermal compartment of wounds treated with 5-FU (control vs. 5-FU, 22.47 ± 8.85 vs. 44.69 ± 5.97, P

Abstract. Vitiligo is a common depigmented skin disease that negatively affects the physical and mental health of patients. The 2018 version of the Vitiligo Treatment Consensus has been updated based on the research progress on vitiligo in the past 3 years in combination with the clinical experiences of experts. The newly revised points include maintenance therapy, early glucocorticoid intervention, and oral mini-pulsed glucocorticoid administration protocols. The prospect of using JAK inhibitors in the treatment of vitiligo is also discussed.

Taking autonomous driving and driverless as the research object, we discuss and define intelligent high-precision map. Intelligent high-precision map is considered as a key link of future travel, a carrier of real-time perception of traffic resources in the entire space-time range, and the criterion for the operation and control of the whole process of the vehicle. As a new form of map, it has distinctive features in terms of cartography theory and application requirements compared with traditional navigation electronic maps. Thus, it is necessary to analyze and discuss its key features and problems to promote the development of research and application of intelligent high-precision map. Accordingly, we propose an information transmission model based on the cartography theory and combine the wheeled robot’s control flow in practical application. Next, we put forward the data logic structure of intelligent high-precision map, and analyze its application in autonomous driving. Then, we summarize the computing mode of “Crowdsourcing+Edge-Cloud Collaborative Computing”, and carry out key technical analysis on how to improve the quality of crowdsourced data. We also analyze the effective application scenarios of intelligent high-precision map in the future. Finally, we present some thoughts and suggestions for the future development of this field.

Abstract. Current treatment of vitiligo is still a great challenge, since most cases of vitiligo have variable re-pigmentation outcomes due to their unpredictable responses to existing therapeutic regimens. There is an urgent need to identify this re-pigmentation process and to develop novel therapies. This review illustrates the most current research and latest understanding of vitiligo skin re-pigmentation and related regulatory mechanisms. Literature was collected from PubMed until January 2020, using the search terms including “vitiligo,” “re-pigmentation,” “phototherapy,” “narrow-band ultraviolet B, ” “excimer,” “fractional carbon dioxide laser,” and “melanocyte stem cells.” Literature was mainly derived from English articles. Article type was not limited. Emerging evidence suggests that patients with vitiligo present various re-pigmentation patterns following ultraviolet B phototherapy, which relies on different cell reservoirs from the perilesional margins and/or from uninvolved hair follicles to replenish functional melanocytes that are lost in vitiliginous skin. The following events are likely to be involved in this re-pigmentation process, including: 1) changes in the paracrine secretion and distribution of transforming growth factor-β1 in the bulge area and in the epidermis; 2) the enhanced transfer of dermal pro-melanogenic growth factors to the epidermis; and 3) the induction of a C-X-C motif chemokine ligand (CXCL) 12-enriched micro-environment that efficiently recruits CXCR4- or CXCR7-positive melanocytes. Ongoing studies on the cellular and molecular events underlying vitiligo re-pigmentation will help design new therapeutic strategies to improve treatment outcomes.

In pursuit of expanding dietary options for those with allergies, we aimed to develop a low‐allergenic fermented milk beverage. We adopted a combination fermentation strategy to enhance the allergy mitigation efficacy of 4 strains of lactic acid bacteria. Our fermentation conditions were optimised with an equal ratio (1:1:1:1) of strains, a total 5% inoculation rate and fermentation at 40°C for 6.5 h. Under conditions, the antigen reduction rates for α‐lactalbumin (α‐LA), β‐lactoglobulin (β‐LG), α‐casein and β‐casein were impressive, ranging from 43.54 to 70.51%. A 28‐day storage assessment showed that the reduction rates of the 4 antigens ranged from 38.98% to 78.06%. Most importantly, it was found through indirect competitive ELISA that the binding ability of immunoglobulin E to α‐LA and β‐LG, which we are concerned about, was significantly reduced compared to the unfermented sample. Notable, the beverage maintained favorable physicochemical properties throughout the storage period. [ABSTRACT FROM AUTHOR]

The initiation and intensity of warm rain are processes dominated by the evolution of cloud droplet spectra. To treat the cloud condensation process properly is a fundamental step for the simulation of warm rain formation. Double-moment bulk schemes with a limited number of prognostic variables cannot simulate the evolution of droplet spectra properly. A triple-moment bulk scheme, however, should overcome the problem of spurious cloud droplet spectrum broadening induced by double-moment schemes. To compare the effects of a newly developed triple-moment scheme with double-moment schemes on warm rain formation, the authors conducted WRF-LES numerical simulations to investigate the impacts of the two types of condensation scheme on rain initiation and intensity. In the early stage of raindrop formation, the simulation with the triple-moment scheme delays the raindrop initiation and produces droplet spectra with smaller average radii than those with the double-moment scheme. In the developing stage, the triple-moment scheme reduces the raindrop water content at the precipitation center. However, the further triple-moment scheme for raindrop is needed to simulate the development of warm rain accurately.

Hierarchical zeolites attract people’s attention due to their enhanced mass transfer properties in catalytic reactions. The research over obtaining these zeolites in green and efficient methods is of great significance for the current post-treatments and templating strategies tend to be costly for hierarchical zeolite synthesis. In this research, nanosized mesoporous ZSM-5 (SN-ZSM-5) zeolites have been synthesized without the addition of mesoscale templates under highly concentrated conditions. The physicochemical characteristics were systematically investigated by XRD, SEM, N2 sorption, TEM, and NMR. The SEM images showed ZSM-5 crystals with sizes between 50–110 nm were obtained. N2 sorption and high-resolution TEM images gave direct evidence for the hierarchical structure of SN-ZSM-5. The forming mechanism for the hierarchical structure was proposed that the etching effect of the highly alkaline environment for the starting gels played a critical role in the formation of hierarchical structure. Catalytic tests in methanol-to-olefins (MTO) showed the SN-ZSM-5 performed a longer catalyst lifetime and higher propylene selectivity than the conventional ZSM-5 zeolites (C-ZSM-5) obtained from a traditional hydrothermal method. The features of hierarchical structure in the SN-ZSM-5 crystals and the sustainability for synthesis method could show a promising choice for wide applications of these SN-ZSM-5 zeolites in the future.

Based on Droplet Measurement Technologies data of a pre-stratiform-cloud precipitation event in Ganzhou, Jiangxi Province, on 11 November 2015, and combined with radar data, this paper comprehensively analyzes the macro- and microphysical characteristics of cloud in the upper trough. The results show that: (1) Detection takes place in the early stage of precipitation and the cloud has multiple layers. The cloud type is stratiform (Sc) and the height of the cloud base is 1009 m, 1009–1700 m is the low Sc layer, 1700–3000 m is the no-cloud level, and 3000 to the maximum height detected is another Sc layer. (2) The Sc is inhomogeneous in the horizontal and vertical directions. The particle number concentration and the effective diameter below the 0 °C layer is significantly higher than that above the 0 °C layer, which is in accordance with the ‘seeder–feeder’ mechanism. Above the 0 °C layer is seeder cloud, where needle, column ice crystals and water droplets coexist, and sublimation and coalescence are the main processes. The morphology of ice crystals changes from needle to column, plate, and polymer as height decreases. Below the 0 °C warm layer is a supply cloud, and the particles develop in the supply cloud with abundant liquid water content. Ice melting and coalescence dominate the warm layer, which makes the effective diameter significantly increase. Down to 4150 m, the ice melts completely into raindrops.