Search

Existing animal and human research support the causal role of stress in the emergence of anhedonia, and in turn, the influence of anhedonia in social functioning. However, this model has not been tested in relation to psychosis-risk; this literature gap is notable given that both anhedonia and declining social functioning represent key markers of risk of developing a psychotic disorder such as schizophrenia. The current research tested the evidence for this model using structural equation modeling in 240 individuals selected based on a range of psychosis-risk symptomatology from the general community. Results supported this model in comparison with alternative models, and additionally emphasized the direct role of perceived stress in social functioning outcomes. Findings suggest the clinical relevance of targeting early perceptions of stress in individuals meeting psychosis-risk self-report criteria in an effort to prevent subsequent anhedonia and declines in social functioning.

The present study examined the associations of positive, negative, and disorganized schizotypy with psychotic-like experiences, affect, and social functioning in daily life using experience sampling methodology (ESM) in 2 samples (ns = 165 and 203) that employed different measures of schizotypy. Schizotypy is a useful framework for understanding schizophrenia-spectrum psychopathology, and ESM offers a powerful approach for assessing schizotypy in real-world settings. Participants were signaled 8 times daily for 7 days to complete ESM questionnaires. As hypothesized, positive schizotypy was robustly associated with psychotic-like experiences in daily life, whereas negative schizotypy was associated with negative experiences, diminished positive affect, and social disinterest in both samples. As expected, disorganized schizotypy was associated with disorganization in daily life. Furthermore, it was associated with increased negative affect and diminished positive affect. Thus, positive, negative, and disorganized schizotypy were associated with unique, hypothesized patterns of experiences in daily life, and the findings across the two samples and two schizotypy measures were strikingly consistent. Note that when disorganized schizotypy was not entered as a predictor in the 2 samples, disorganized experiences and negative affect in daily life were associated with positive schizotypy. However, when disorganized schizotypy was included as a predictor, these daily life experiences were associated with disorganized, not positive, schizotypy. This is similar to findings from interview and questionnaire studies that have simultaneously assessed positive, negative, and disorganized schizotypy. The findings support the construct validity of the multidimensional model of schizotypy and the importance of including disorganization in the conceptualization and assessment of schizotypy. (PsycInfo Database Record (c) 2020 APA, all rights reserved).

Individuals at risk for schizophrenia-spectrum disorders tend to make atypical attributions of significance to unimportant stimuli. This experience of heightened significance, known as aberrant salience, is thought to contribute to psychotic symptoms. The Aberrant Salience Inventory (ASI) was designed to capture subclinical and clinical manifestations of the construct, and scores on the scale are associated with schizophrenia-like symptoms and behaviors in laboratory studies. Experience sampling methodology (ESM) studies have assessed momentary experiences of aberrant salience in daily life, but to our knowledge no study has examined real-world outcomes using the ASI as a trait measure of aberrant salience. The current study assessed the expression of aberrant salience in undergraduates oversampled for positive and negative schizotypy using ESM. Overall, findings of the expression of aberrant salience in daily life were similar to previous findings with positive schizotypy. Aberrant salience was associated with psychotic-like and disorganized symptoms, suspiciousness, and social impairment in daily life. It was unassociated with negative symptoms, stress, or affect in the moment. Aberrant salience did not moderate daily life associations of stress with schizotypic symptoms. The ASI subscales showed differential patterns of associations in daily life. These findings support the construct validity of the ASI and suggest that aberrant salience traits are relevant for real-world outcomes in schizotypy-spectrum psychopathology.

Background Social anxiety disorder (SAD) commonly occurs among individuals at clinical high-risk (CHR) for psychosis. Extant research has yet to examine the prevalence and clinical/functional correlates of SAD in this population compared to a community control (CC) sample. This comparison may improve the generalizability that traditional nonpsychiatric control samples cannot provide. Additionally, it remains unknown how SAD contributes to symptom severity and social impairments in individuals at CHR for psychosis. Methods Both CHR and CC groups were recruited from general community sources; CC participants were not excluded in this analysis on the basis of any psychopathology except psychosis. A total of 245 adolescents and young adults (CHR = 81; CC = 164) were administered the Social Phobia Scale, the Structured Interview for Psychosis-risk Syndromes, Structured Clinical Interview for DSM-5 Research Version, and the Social Functioning Scale. Results The CHR group was at increased risk for having SAD relative to CC (42% CHR; 13% CC; RR = 3.28) and, to a lesser degree, a non-SAD anxiety disorder (41% CHR; 29% CC; RR = 1.42). Greater social anxiety was related to higher levels of negative (r = 0.29) but not positive (r = 0.05) symptoms within the CHR group. Furthermore, elevated social anxiety was found to be linked with poor social functioning in the CHR group (r = −0.31). Conclusions These findings demonstrate the specificity of SAD over and above other anxiety disorders in individuals at CHR for psychosis and the critical target of SAD to treat subclinical psychotic symptoms and social functioning.

BACKGROUND: Certain traits of positive schizotypy, such as odd beliefs, unusual perceptual experiences, suspiciousness, and referential thinking show associations with aberrant salience. Positive schizotypy may involve hyper-attribution of salience toward insignificant events, whereas negative schizotypy may involve hypo-attribution of salience, even toward important events. Salience attribution is thought to involve dopamine-mediated processes, a mechanism that appears disrupted in schizotypy; however, little is known about the cognitive processes potentially underlying salience attribution. METHODS: The present study assessed the relationship between latent inhibition and aberrant salience, as well as their associations with positive and negative schizotypy. Salience was measured across various levels of processing, including sensitivity to visual salience, behavioral and cognitive outcomes on a contingency illusion task, and self-reported experience of salience. RESULTS: Schizotypy symptoms were differentially associated with self-reported experiences of aberrant salience: positive schizotypy showed positive associations and negative schizotypy showed inverse associations. Significant salience effects were found across all participants, suggesting that task manipulations were successful; however, neither schizotypy dimension was associated with visual salience, contingency illusions, or latent inhibition. Additionally, salience measures were generally unassociated across levels of processing. DISCUSSION: Salience processing across perceptual, behavioral, and experiential levels likely involves different mechanisms, some of which may not show major disruption in subclinical manifestations of schizotypy. Inclusion of social and affective factors in addition to cognitive variables is recommended for future study.

The present study examined the expression of the Diagnostic and Statistical Manual of Mental Disorders, fifth edition (DSM-5) schizotypal, schizoid, and paranoid personality disorder (PD) traits in daily life using experience sampling methodology in 206 nonclinically ascertained Spanish young adults oversampled for risk for schizophrenia-spectrum psychopathology. This study examined the overlap and differentiation of pathological personality traits in daily life settings, according to both diagnostic and multidimensional models. Daily life outcomes differentiated among schizophrenia-spectrum disorders. The assignment of Cluster A personality traits to positive, negative, paranoid, and disorganized dimensions provided an alternative to the traditional PD diagnoses. Positive, disorganized, and paranoid schizotypy were associated with elevated stress reactivity, whereas negative schizotypy was associated with diminished reactivity in daily life. The current diagnostic model is limited by the considerable overlap among the PD traits. Nonetheless, experience sampling methodology is sensitive enough to detect differences in day-to-day impairment and can be a powerful research tool for the examination of dynamic constructs such as personality pathology. (PsycINFO Database Record

This review examined the assessment of posttraumatic stress symptoms (PTSS) in daily life using experience sampling methodology (ESM)/ecological momentary assessment (EMA) and daily diary studies in adult samples. Fifteen peer-reviewed studies were identified and categorized into areas of total PTSD/multiple PTSS (studies including three or more symptom clusters), intrusive memories, and mood and anxiety symptoms. Overall, ESM and the daily diary method proved feasible for assessing the real-world expression of PTSS, resulted in minimal reactivity, and offered a number of advantages over classical assessment. Even within the two measurement types of ESM and daily diary, there was great variability in study design and analysis. The benefits and limitations of the different approaches are discussed. Different themes in content emerged as well, such as coping strategies and affective instability throughout the course of a day. Gaps in our current understanding are highlighted and suggestions for methodology and future areas of research are proposed.

Reports an error in "Individual differences in the executive control of attention, memory, and thought, and their associations with schizotypy" by Michael J. Kane, Matt E. Meier, Bridget A. Smeekens, Georgina M. Gross, Charlotte A. Chun, Paul J. Silvia and Thomas R. Kwapil (

Undergraduates ( N = 274) participated in a weeklong daily-life experience-sampling study of mind wandering after being assessed in the lab for executive-control abilities (working memory capacity; attention-restraint ability; attention-constraint ability; and propensity for task-unrelated thoughts, or TUTs) and personality traits. Eight times a day, electronic devices prompted subjects to report on their current thoughts and context. Working memory capacity and attention abilities predicted subjects’ TUT rates in the lab, but predicted the frequency of daily-life mind wandering only as a function of subjects’ momentary attempts to concentrate. This pattern replicates prior daily-life findings but conflicts with laboratory findings. Results for personality factors also revealed different associations in the lab and daily life: Only neuroticism predicted TUT rate in the lab, but only openness predicted mind-wandering rate in daily life (both predicted the content of daily-life mind wandering). Cognitive and personality factors also predicted dimensions of everyday thought other than mind wandering, such as subjective judgments of controllability of thought. Mind wandering in people’s daily environments and TUTs during controlled and artificial laboratory tasks have different correlates (and perhaps causes). Thus, mind-wandering theories based solely on lab phenomena may be incomplete.

Ambivalence, which refers to the simultaneous experience of contradictory emotions and cognitions, has a longstanding and important role in the study of both normal and pathological functioning. Bleuler and Meehl viewed ambivalence as a central component of schizophrenic, and more broadly schizotypic, psychopathology. Ambivalence is associated with questionnaire and interview measures of schizotypic symptoms and impairment. However, its real-world expression has not been explored. The present study examined the expression of ambivalence, as assessed by the Schizotypal Ambivalence Scale, in daily life using experience sampling methodology. Specifically, it examined the association of ambivalence with affect, daily activities, and social and cognitive functioning in the moment. A sample of 430 male and female young adults completed an average of 42 daily life assessments during a one-week period. Ambivalence predicted diminished positive affect, increased negative affect, cognitive impairment, and social impairment. Furthermore, ambivalence moderated the effects of social closeness, emotional expression, and activity enjoyment on affect and functioning in daily life. Specifically, ambivalence was associated with affective dysregulation and greater reactivity to social stress. The present findings provided the first examination of the expression of ambivalence in daily life and support its inclusion as a component of schizophrenia-spectrum psychopathology.

Positive and negative schizotypy exhibit differential patterns of impairment in social relations, affect, and functioning in daily life. However, studies have not examined the association of schizotypy with real-world expression of psychotic-like, paranoid, and negative symptoms. The present study employed experience-sampling methodology (ESM) to assess positive and negative schizotypy in daily life in a nonclinical sample of 206 Spanish young adults. Participants were prompted randomly 8 times daily for 1 week to complete assessments of their current symptoms and experiences. Positive schizotypy was associated with psychotic-like and paranoid symptoms in daily life. Negative schizotypy was associated with a subset of these symptoms and with negative symptoms in daily life. Momentary stress was associated with psychotic-like and paranoid symptoms, but only for those high in positive schizotypy. Social stress predicted momentary psychotic-like symptoms in both positive and negative schizotypy. Time-lagged analyses indicated that stress at the preceding signal predicted psychotic-like symptoms at the current assessment, but only for individuals high in positive schizotypy. The results are consistent with models linking stress sensitivity with the experience of psychotic symptoms. The findings provide cross-cultural support for the multidimensional model of schizotypy and schizophrenia. Furthermore, the findings demonstrate that ESM is an effective method for predicting the experience of psychotic-like symptoms, as well as their precursors, in daily life.

A large correlational study took a latent-variable approach to the generality of executive control by testing the individual-differences structure of executive-attention capabilities and assessing their prediction of schizotypy, a multidimensional construct (with negative, positive, disorganized, and paranoid factors) conveying risk for schizophrenia. Although schizophrenia is convincingly linked to executive deficits, the schizotypy literature is equivocal. Subjects completed tasks of working memory capacity (WMC), attention restraint (inhibiting prepotent responses), and attention constraint (focusing visual attention amid distractors), the latter 2 in an effort to fractionate the "inhibition" construct. We also assessed mind-wandering propensity (via in-task thought probes) and coefficient of variation in response times (RT CoV) from several tasks as more novel indices of executive attention. WMC, attention restraint, attention constraint, mind wandering, and RT CoV were correlated but separable constructs, indicating some distinctions among "attention control" abilities; WMC correlated more strongly with attentional restraint than constraint, and mind wandering correlated more strongly with attentional restraint, attentional constraint, and RT CoV than with WMC. Across structural models, no executive construct predicted negative schizotypy and only mind wandering and RT CoV consistently (but modestly) predicted positive, disorganized, and paranoid schizotypy; stalwart executive constructs in the schizophrenia literature-WMC and attention restraint-showed little to no predictive power, beyond restraint's prediction of paranoia. Either executive deficits are consequences rather than risk factors for schizophrenia, or executive failures barely precede or precipitate diagnosable schizophrenia symptoms. (PsycINFO Database Record

Current conceptualizations of schizophrenia indicate that the underlying vulnerability for the disorder is expressed across a broad continuum of impairment referred to as schizotypy. Trait-like anhedonia has long been recognized as a central component of schizophrenia and schizotypy. Our understanding of the etiology, experience, and expression of anhedonia, however, has evolved in large part due to advances in social and emotion psychology regarding the nature of pleasure, advances in the neurosciences regarding the brain mechanisms underlying hedonic capacity and experience, and the integration of measures from clinical, social, and biological psychology. Current studies have differentiated deficits in anticipatory pleasure from deficits in consummatory pleasure. The study of anhedonia has also been enhanced by the use of experience sampling research methods that expand investigations from the laboratory and the clinic to real world environments. Anhedonia appears to be a core component of the negative or deficit symptom dimension of schizotypy and schizophrenia, whereas the positive or psychotic-like dimension appears to be characterized by affective dysregulation. Furthermore, schizotypic anhedonia is differentiated from conditions such as depression, which involve episodic anhedonia combined with elevated negative affect. The present chapter presents an overview of theoretical conceptualizations of anhedonia in schizotypy, reviews cross-sectional, longitudinal, and daily life research findings, and considers issues and directions for future study of the construct.

Evidence suggests that divergent thinking (DT), a measure of creativity, is associated with positive schizotypy and cannabis use. Given the high rates of cannabis use among those with schizotypy, it is unclear if the relation of DT to schizotypy is due to co-occurring cannabis use. In this study, we examined the relations between DT, schizotypy, and cannabis use among positive schizotypy (n=66), negative schizotypy (n=22), and non-schizotypy (n=60) groups. Results revealed that DT was greater in the positive schizotypy group, on the order of small to medium effects, compared to negative and non-schizotypy groups. Cannabis use and DT were associated in the non-schizotypy group, but not in the positive or negative schizotypy groups. Across all groups, positive schizotypy significantly predicted DT; however, cannabis use was not a significant predictor of DT. In line with previous findings, cannabis use and DT were only related in individuals low in creativity. This suggests that a ceiling effect may be present, with only cannabis users who are low in creativity receiving any increase in DT. Future research should aim to clarify the DT-cannabis relationship.

Although neurocognitive deficits are an integral characteristic of schizophrenia, there is inconclusive evidence as to whether they manifest across the schizophrenia-spectrum. We conducted two studies and a meta-analysis comparing neurocognitive functioning between psychometrically defined schizotypy and control groups recruited from a college population. Study One compared groups on measures of specific and global neurocognition, and subjective and objective quality of life. Study Two examined working memory and subjective cognitive complaints. Across both studies, the schizotypy group showed notably decreased subjective (d = 1.52) and objective (d = 1.02) quality of life and greater subjective cognitive complaints (d = 1.88); however, neurocognition was normal across all measures (d's < .35). Our meta-analysis of 33 studies examining neurocognition in at-risk college students revealed between-group differences in the negligible effect size range for most domains. The schizotypy group demonstrated deficits of a small effect size for working memory and set-shifting abilities. Although at-risk individuals report relatively profound neurocognitive deficits and impoverished quality of life, neurocognitive functioning assessed behaviorally is largely intact. Our data suggest that traditionally defined neurocognitive deficits do not approximate the magnitude of subjective complaints associated with psychometrically defined schizotypy. (JINS, 2013, 19, 1–14)