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9 results on '"Centola, Garrick"'

2. Mechanistic Analysis of an Extracellular Signal–Regulated Kinase 2–Interacting Compound that Inhibits Mutant BRAF-Expressing Melanoma Cells by Inducing Oxidative Stress

Author

Martinez, Ramon, primary, Huang, Weiliang, additional, Samadani, Ramin, additional, Mackowiak, Bryan, additional, Centola, Garrick, additional, Chen, Lijia, additional, Conlon, Ivie L., additional, Hom, Kellie, additional, Kane, Maureen A., additional, Fletcher, Steven, additional, and Shapiro, Paul, additional

Published
2020
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4. Nine-Residue Peptide Self-Assembles in the Presence of Silver to Produce a Self-Healing, Cytocompatible, Antimicrobial Hydrogel

Author

D’Souza, Areetha, primary, Yoon, Jennifer H., additional, Beaman, Henry, additional, Gosavi, Pallavi, additional, Lengyel-Zhand, Zsofia, additional, Sternisha, Alex, additional, Centola, Garrick, additional, Marshall, Liam R., additional, Wehrman, Matthew D., additional, Schultz, Kelly M., additional, Monroe, Mary Beth, additional, and Makhlynets, Olga V., additional

Published
2020
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5. Crystal structures of (R S)-N-[(1R,2S)-2-benz­yloxy-1-(2,6-di­methyl­phen­yl)prop­yl]-2-methyl­propane-2-sulfinamide and (R S)-N-[(1S,2R)-2-benz­yloxy-1-(2,4,6-tri­methyl­phen­yl)prop­yl]-2-methyl­propane-2-sulfinamide: two related protected 1,2-amino alcohols

Author

Carbone, Matthew R., Centola, Garrick A., Haas, Adam, McClelland, Kevin P., Moskowitz, Michael D., Verderame, Angelo M., Olezeski, Mikael S., Papa, Louis J., Dorn, Stephanie C. M., Brennessel, William W., and Weix, Daniel J.

Subjects
diastereomer, crystal structure, column chromatography, sulfinamide, amino alcohol, hydrogen bonding, NMR, Research Communications
Abstract

Mol­ecules of two related 1,2-amino alcohols are linked via N—H⋯O=S hydrogen bonds, forming chains along [100] for the first compound and along [010] for the second compound., The title compounds, C22H31NO2S, (1), and C23H33NO2S, (2), are related protected 1,2-amino alcohols. They differ in the substituents on the benzene ring, viz. 2,6-di­methyl­phenyl in (1) and 2,4,6-tri­methyl­phenyl in (2). The plane of the phenyl ring is inclined to that of the benzene ring by 28.52 (7)° in (1) and by 44.65 (19)° in (2). In the crystal of (1), N—H⋯O=S and C—H⋯O=S hydrogen bonds link mol­ecules, forming chains along [100], while in (2), similar hydrogen bonds link mol­ecules into chains along [010]. The absolute structures of both compounds were determined by resonance scattering.

Published
2014

8. Nine-Residue Peptide Self-Assembles in the Presence of Silver to Produce a Self-Healing, Cytocompatible, Antimicrobial Hydrogel

Author

D’Souza, Areetha, Yoon, Jennifer H., Beaman, Henry, Gosavi, Pallavi, Lengyel-Zhand, Zsofia, Sternisha, Alex, Centola, Garrick, Marshall, Liam R., Wehrman, Matthew D., Schultz, Kelly M., Monroe, Mary Beth, and Makhlynets, Olga V.

Abstract

Silver compounds have been used extensively for wound healing because of their antimicrobial properties, but high concentrations of silver are toxic to mammalian cells. We designed a peptide that binds silver and releases only small amounts of this ion over time, therefore overcoming the problem of silver toxicity. Silver binding was achieved through incorporation of an unnatural amino acid, 3′-pyridyl alanine (3′-PyA), into the peptide sequence. Upon the addition of silver ions, the peptide adopts a beta-sheet secondary structure and self-assembles into a strong hydrogel as characterized by rheology, circular dichroism, and transmission electron microscopy. We show that the resulting hydrogel kills Escherichia coliand Staphylococcus aureusbut is not toxic to fibroblasts and could be used for wound healing. The amount of Ag(I) released by hydrogels into the solution is less than 4% and this low amount of Ag(I) does not change in the pH range 6–8. These studies provide an initial indication for use of the designed hydrogel as injectable, antimicrobial wound dressing.

Published
2024
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9. Crystal structures of (RS)-N-[(1R,2S)-2-benzyloxy-1-(2,6-dimethylphenyl)propyl]-2-methylpropane-2-sulfinamide and (RS)-N-[(1S,2R)-2-benzyloxy-1-(2,4,6-trimethylphenyl)propyl]-2-methylpropane-2-sulfinamide: two related protected 1,2-amino alcohols

Author

Carbone, Matthew R., primary, Centola, Garrick A., additional, Haas, Adam, additional, McClelland, Kevin P., additional, Moskowitz, Michael D., additional, Verderame, Angelo M., additional, Olezeski, Mikael S., additional, Papa, Louis J., additional, Dorn, Stephanie C. M., additional, Brennessel, William W., additional, and Weix, Daniel J., additional

Published
2014
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