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1. Supplementary Table from Circulating Tumor and Immune Cells for Minimally Invasive Risk Stratification of Smoldering Multiple Myeloma

Author

Bruno Paiva, Jesus F. San-Miguel, Aldo M. Roccaro, Hervé Avet-Loiseau, Hartmut Goldschmidt, Alberto Orfao, Juan Flores-Montero, Maria-Victoria Mateos, Noemi Puig, Pablo Rios, Maria Sarasa, Luis Palomera, José-Ángel Hernández-Rivas, Javier de la Rubia, Albert Oriol, Maialen Sirvent, Valentin Cabañas, Adrian Alegre, Maria Casanova, Antoni Garcia-Guiñon, Heinz Ludwig, Felipe De Arriba, Clara Gomez, Helena Vitoria, Catarina Geraldes, Artur Paiva, Rebeca Iglesias, Fernando Solano, Joaquin Martinez-Lopez, Roman Hájek, Enrique M. Ocio, Maria-Elena Cabezudo, Joan Bargay, Felipe Prosper, Luis-Esteban Tamariz-Amador, Aitziber Lopez, Juan-Jose Garces, Cirino Botta, Camilla Guerrero, Esperanza Martín-Sánchez, Catarina Maia, Cristina Perez, Cristina Moreno, Sara Rodriguez, Alessandra Tucci, Viviana Giustini, Marco Chiarini, Antonio Sacco, Francois Vergez, Jill Corre, Anna Luise Grab, Elias K. Mai, Niels Weinhold, Marc Raab, Tomáš Jelínek, Albert Perez-Montaña, Evangelos Terpos, David Žihala, and Rosalinda Termini

Abstract

Supplementary Table from Circulating Tumor and Immune Cells for Minimally Invasive Risk Stratification of Smoldering Multiple Myeloma

Published
2023
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2. Supplementary Figure from Circulating Tumor and Immune Cells for Minimally Invasive Risk Stratification of Smoldering Multiple Myeloma

Author

Bruno Paiva, Jesus F. San-Miguel, Aldo M. Roccaro, Hervé Avet-Loiseau, Hartmut Goldschmidt, Alberto Orfao, Juan Flores-Montero, Maria-Victoria Mateos, Noemi Puig, Pablo Rios, Maria Sarasa, Luis Palomera, José-Ángel Hernández-Rivas, Javier de la Rubia, Albert Oriol, Maialen Sirvent, Valentin Cabañas, Adrian Alegre, Maria Casanova, Antoni Garcia-Guiñon, Heinz Ludwig, Felipe De Arriba, Clara Gomez, Helena Vitoria, Catarina Geraldes, Artur Paiva, Rebeca Iglesias, Fernando Solano, Joaquin Martinez-Lopez, Roman Hájek, Enrique M. Ocio, Maria-Elena Cabezudo, Joan Bargay, Felipe Prosper, Luis-Esteban Tamariz-Amador, Aitziber Lopez, Juan-Jose Garces, Cirino Botta, Camilla Guerrero, Esperanza Martín-Sánchez, Catarina Maia, Cristina Perez, Cristina Moreno, Sara Rodriguez, Alessandra Tucci, Viviana Giustini, Marco Chiarini, Antonio Sacco, Francois Vergez, Jill Corre, Anna Luise Grab, Elias K. Mai, Niels Weinhold, Marc Raab, Tomáš Jelínek, Albert Perez-Montaña, Evangelos Terpos, David Žihala, and Rosalinda Termini

Abstract

Supplementary Figure from Circulating Tumor and Immune Cells for Minimally Invasive Risk Stratification of Smoldering Multiple Myeloma

Published
2023
Full Text
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3. Supplementary Data from Circulating Tumor and Immune Cells for Minimally Invasive Risk Stratification of Smoldering Multiple Myeloma

Author

Bruno Paiva, Jesus F. San-Miguel, Aldo M. Roccaro, Hervé Avet-Loiseau, Hartmut Goldschmidt, Alberto Orfao, Juan Flores-Montero, Maria-Victoria Mateos, Noemi Puig, Pablo Rios, Maria Sarasa, Luis Palomera, José-Ángel Hernández-Rivas, Javier de la Rubia, Albert Oriol, Maialen Sirvent, Valentin Cabañas, Adrian Alegre, Maria Casanova, Antoni Garcia-Guiñon, Heinz Ludwig, Felipe De Arriba, Clara Gomez, Helena Vitoria, Catarina Geraldes, Artur Paiva, Rebeca Iglesias, Fernando Solano, Joaquin Martinez-Lopez, Roman Hájek, Enrique M. Ocio, Maria-Elena Cabezudo, Joan Bargay, Felipe Prosper, Luis-Esteban Tamariz-Amador, Aitziber Lopez, Juan-Jose Garces, Cirino Botta, Camilla Guerrero, Esperanza Martín-Sánchez, Catarina Maia, Cristina Perez, Cristina Moreno, Sara Rodriguez, Alessandra Tucci, Viviana Giustini, Marco Chiarini, Antonio Sacco, Francois Vergez, Jill Corre, Anna Luise Grab, Elias K. Mai, Niels Weinhold, Marc Raab, Tomáš Jelínek, Albert Perez-Montaña, Evangelos Terpos, David Žihala, and Rosalinda Termini

Abstract

Supplementary Data from Circulating Tumor and Immune Cells for Minimally Invasive Risk Stratification of Smoldering Multiple Myeloma

Published
2023
Full Text
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4. Data from Circulating Tumor and Immune Cells for Minimally Invasive Risk Stratification of Smoldering Multiple Myeloma

Author

Bruno Paiva, Jesus F. San-Miguel, Aldo M. Roccaro, Hervé Avet-Loiseau, Hartmut Goldschmidt, Alberto Orfao, Juan Flores-Montero, Maria-Victoria Mateos, Noemi Puig, Pablo Rios, Maria Sarasa, Luis Palomera, José-Ángel Hernández-Rivas, Javier de la Rubia, Albert Oriol, Maialen Sirvent, Valentin Cabañas, Adrian Alegre, Maria Casanova, Antoni Garcia-Guiñon, Heinz Ludwig, Felipe De Arriba, Clara Gomez, Helena Vitoria, Catarina Geraldes, Artur Paiva, Rebeca Iglesias, Fernando Solano, Joaquin Martinez-Lopez, Roman Hájek, Enrique M. Ocio, Maria-Elena Cabezudo, Joan Bargay, Felipe Prosper, Luis-Esteban Tamariz-Amador, Aitziber Lopez, Juan-Jose Garces, Cirino Botta, Camilla Guerrero, Esperanza Martín-Sánchez, Catarina Maia, Cristina Perez, Cristina Moreno, Sara Rodriguez, Alessandra Tucci, Viviana Giustini, Marco Chiarini, Antonio Sacco, Francois Vergez, Jill Corre, Anna Luise Grab, Elias K. Mai, Niels Weinhold, Marc Raab, Tomáš Jelínek, Albert Perez-Montaña, Evangelos Terpos, David Žihala, and Rosalinda Termini

Abstract

Purpose:Early intervention in smoldering multiple myeloma (SMM) requires optimal risk stratification to avoid under- and overtreatment. We hypothesized that replacing bone marrow (BM) plasma cells (PC) for circulating tumor cells (CTC), and adding immune biomarkers in peripheral blood (PB) for the identification of patients at risk of progression due to lost immune surveillance, could improve the International Myeloma Working Group 20/2/20 model.Experimental Design:We report the outcomes of 150 patients with SMM enrolled in the iMMunocell study, in which serial assessment of tumor and immune cells in PB was performed every 6 months for a period of 3 years since enrollment.Results:Patients with >0.015% versus ≤0.015% CTCs at baseline had a median time-to-progression of 17 months versus not reached (HR, 4.9; P 20% BM PCs had no prognostic value in a multivariate analysis that included serum free light-chain ratio >20, >2 g/dL M-protein, and >0.015% CTCs. The 20/2/20 and 20/2/0.015 models yielded similar risk stratification (C-index of 0.76 and 0.78). The combination of the 20/2/0.015 model with an immune risk score based on the percentages of SLAN+ and SLAN− nonclassical monocytes, CD69+HLADR+ cytotoxic NK cells, and CD4+CXCR3+ stem central memory T cells, allowed patient’ stratification into low, intermediate-low, intermediate-high, and high-risk disease with 0%, 20%, 39%, and 73% rates of progression at 2 years.Conclusions:This study showed that CTCs outperform BM PCs for assessing tumor burden. Additional analysis in larger series are needed to define a consensus cutoff of CTCs for minimally invasive stratification of SMM.

Published
2023
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5. The Role of the Interdisciplinary Team in Subacute Rehabilitation for Central Pontine Myelinolysis

Author

Camilla Guerrero, Maybel Kyin, Katelyn Fuller, Marie Yeseta, and Cathelyn Timple

Subjects
Adult, 030506 rehabilitation, medicine.medical_specialty, medicine.medical_treatment, Physical Therapy, Sports Therapy and Rehabilitation, 03 medical and health sciences, 0302 clinical medicine, Physical medicine and rehabilitation, medicine, Humans, Retrospective Studies, Rehabilitation, business.industry, fungi, food and beverages, Recovery of Function, Patient-centered care, Prognosis, medicine.disease, Magnetic Resonance Imaging, Myelinolysis, Central Pontine, Central pontine myelinolysis, Female, Locked-in syndrome, 0305 other medical science, business, 030217 neurology & neurosurgery, Inpatient rehabilitation, Multidisciplinary rehabilitation
Abstract

Background: Central pontine myelinolysis is a rare condition that can result in debilitating symptoms. Recent evidence suggests a shift in hypothesized prognosis for individuals with this diagnosis...

Published
2019
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6. The role of the interdisciplinary team in subacute rehabilitation for central pontine myelinolysis.

Author

Fuller, Katelyn, Guerrero, Camilla, Kyin, Maybel, Timple, Cathelyn, and Yeseta, Marie

Subjects
BRAIN diseases, DEGLUTITION, DEMYELINATION, HEALTH care teams, INTERPROFESSIONAL relations, RANGE of motion of joints, METABOLIC disorders, OCCUPATIONAL therapy, PHYSICAL therapy, SPEECH therapy, SUBACUTE care, ACTIVITIES of daily living, FUNCTIONAL training, TREATMENT effectiveness, PATIENT-centered care, LOCKED-in syndrome
Abstract

Background: Central pontine myelinolysis is a rare condition that can result in debilitating symptoms. Recent evidence suggests a shift in hypothesized prognosis for individuals with this diagnosis and implies a valuable role for rehabilitation to address prevention of secondary complications and functional recovery. This paper describes a 30 year-old female with central pontine myelinolysis presenting with incomplete locked-in syndrome and chronicles her rehabilitative journey at a comprehensive post-acute rehabilitation center. We present discipline specific interventions and discuss the interactions of the rehabilitation team as it relates to this patient's care and progression of training. Methods: Retrospective review of medical records and face-to-face interview were use to compile data for this case report. Results: The patient demonstrated improvements in function in all areas of mobility, swallowing, communication, and self-care over the course of 6 weeks of interdisciplinary training. Conclusion: This report illustrates the critical role of a patient-centered and goal-driven interdisciplinary team approach in the rehabilitation of persons with central pontine myelinolysis. Central Pontine Myelinolysis can result in profound acute disability, including incomplete locked-in syndrome. Interdisciplinary post-acute rehabilitation is beneficial in maximizing functional recovery and minimizing secondary complications for individuals with Central Pontine Myelinolysis. Ongoing clinical assessment and team collaboration contribute to progressive and comprehensive plan of care development in post-acute rehabilitation. A patient-centered and goal-driven interdisciplinary team approach facilitates improvement in outcomes across clinical domains. Recovery potential and therapeutic interventions for individuals with Central Pontine Myelinolysis need to be further explored. [ABSTRACT FROM AUTHOR]

Published
2020
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9. International Cuisine

Author

Nenes, Michael F. and Nenes, Michael F.

Subjects
Cookery, International
Abstract

'The International Culinary Schools at The Art Institutes.'

Published
2009

10. OBITUARIES

Subjects
Business, General interest
Abstract

Dec. 21, 1918 - Jan. 23, 2009 William Edward Bennington, 90, Sarasota died Jan. 23, 2009. Visitation will be from 3 to 5 p.m. Thursday, with services to follow, at [...]

Published
2009

11. Herald Tribune Obituaries

Subjects
Business, General interest
Abstract

Bennington, William Edward Dec. 21, 1918 - Jan. 23, 2009 William Edward Bennington, 90, Sarasota died Jan. 23, 2009. Visitation will be from 3 to 5 p.m. Thursday, with services [...]

Published
2009

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