7,234 results on '"Busse W"'
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2. Wie studiert man neuere Sprachen? Ein Ratgeber für alle, die sich dem Studium des Deutschen, Englischen und Französischen widmen Bruno Busse W. Violet
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Horn, Wilhelm
- Published
- 1905
3. Über den Keimkraft-Apparat für Rübensaaten von E. Scharf H. Busse W. Busse P. Ulrich
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Tobler, Gertrud
- Published
- 1909
4. Efficacité à long terme du dupilumab chez des patients souffrant d’asthme de type 2 en fonction de l’âge au moment de l’apparition : LIBERTY ASTHMA TRAVERSE
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Busse, W., primary, Soumagne, T., additional, Kraft, M., additional, Domingo, C., additional, de Mir, I., additional, Maselli, D., additional, Soler, X., additional, Xia, C., additional, Pandit-Abid, N., additional, Jacob-Nara, J., additional, Sacks, H., additional, Rowe, P., additional, and Deniz, Y., additional
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- 2024
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5. Efficacité du dupilumab chez des patients avec et sans réduction minimale importante de la fraction de monoxyde d’azote dans l’air expiré après 2 semaines
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Pavord, I., primary, Guilleminault, L., additional, Wechsler, M., additional, Busse, W., additional, Domingo, C., additional, Xia, C., additional, Gall, R., additional, Pandit-Abid, N., additional, Jacob-Nara, J., additional, Radwan, A., additional, Rowe, P., additional, and Deniz, Y., additional
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- 2024
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6. Comparison of Asthma Phenotypes in Severe Asthma Cohorts (SARP, U-BIOPRED, ProAR and COREA) From 4 Continents.
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Park SY, Fowler S, Shaw DE, Adcock IM, Sousa AR, Djukanovic R, Dahlen SE, Sterk PJ, Kermani NZ, Calhoun W, Israel E, Castro M, Mauger D, Meyers D, Bleecker E, Moore W, Busse W, Jarjour N, Denlinger L, Levy B, Choi BH, Kim SH, Jang AS, Lee T, Cho YJ, Shin YS, Cho SH, Won S, Cruz AA, Wenzel SE, Chung KF, and Kim TB
- Abstract
Purpose: Asthma is a clinical syndrome with various underlying pathomechanisms and clinical phenotypes. Genetic, ethnic, and geographic factors may influence the differences in clinical presentation, severity, and prognosis. We compared the characteristics of asthma based on the geographical background by analyzing representative cohorts from the United States, Europe, South America, and Asia using the Severe Asthma Research Program (SARP), Unbiased Biomarkers for the Prediction of Respiratory Disease Outcomes (U-BIOPRED), Program for Control of Asthma in Bahia (ProAR), and Cohort for Reality and Evolution of Adult Asthma in Korea (COREA), respectively., Methods: The clinical characteristics and medications for the SARP (n = 669), U-BIOPRED (n = 509), ProAR (n = 996), and COREA (n = 3,748) were analyzed. Subgroup analysis was performed for severe asthma., Results: The mean age was highest and lowest in the COREA and SARP, respectively. The asthma onset age was lowest in the ProAR. The mean body mass index was highest and lowest in the SARP and COREA, respectively. Baseline pulmonary function was lowest and highest in the U-BIOPRED and COREA, respectively. The number of patients with acute exacerbation in the previous year was highest in U-BIOPRED. The mean blood eosinophil count was highest in COREA. The total immunoglobulin E was highest in the ProAR. The frequency of atopy was highest in the SARP. The principal component analysis plot revealed differences among all cohorts., Conclusions: The cohorts from 4 different continents exhibited different clinical and physiological characteristics, probably resulting from the interplay between genetic susceptibility and geographical factors., Competing Interests: There are no financial or other issues that might lead to conflict of interest., (Copyright © 2024 The Korean Academy of Asthma, Allergy and Clinical Immunology • The Korean Academy of Pediatric Allergy and Respiratory Disease.)
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- 2024
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7. FRACTIONAL EXHALED NITRIC OXIDE (FENO) IS A STABLE BIOMARKER IN PATIENTS WITH UNCONTROLLED ASTHMA
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Busse, W., primary, Pavord, I., additional, Wechsler, M., additional, Davila, I., additional, Altincatal, A., additional, Soler, X., additional, Choi, M., additional, and Hardin, M., additional
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- 2023
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8. Allergy, asthma, and immunology from infancy adulthood, 3rd edition. C. Warren Bierman, David Pearlman, Gail G. Shapiro, William W. Busse. W. Saunders Company 1996, Philadelphia: 805 pp
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Stark, James M., primary
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- 1996
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9. Allergy, asthma, and immunology from infancy to adulthood, 3rd edition. C. Warren Bierman, David S. Pearlman, Gail G. Shapiro, William W. Busse. W. B. Saunders Company 1996, Philadelphia: 805 pp
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Kercsmar, Carolyn M., primary
- Published
- 1996
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10. Allergy, asthma, and immunology from infancy adulthood, 3rd edition. C. Warren Bierman, David Pearlman, Gail G. Shapiro, William W. Busse. W. Saunders Company 1996, Philadelphia: 805 pp
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James M. Stark
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Pulmonary and Respiratory Medicine ,Allergy ,Psychoanalysis ,business.industry ,Pediatrics, Perinatology and Child Health ,Medicine ,business ,medicine.disease ,Asthma - Published
- 1996
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11. Asthma Updates: Theories Translated to Targeted Treatment.
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Busse W and Castro M
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- Humans, Asthma drug therapy, Asthma epidemiology
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- 2024
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12. Functional Analysis of Sputum Eosinophil Subpopulations in Children With Asthma
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Wilson, G., primary, Liu, Q., additional, Knight, J., additional, Shelar, A., additional, Stewart, E., additional, Visness, C., additional, Sanders, J., additional, Gill, M., additional, Gruchalla, R.S., additional, Liu, A.H., additional, Kattan, M., additional, Hershey, G.N., additional, Togias, A., additional, Becker, P.M., additional, Altman, M., additional, Busse, W., additional, Jackson, D.J., additional, Montgomery, R., additional, and Chupp, G.L., additional
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- 2023
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13. Dupilumab Induces Clinical Remission in Patients With Uncontrolled, Moderate-to-Severe, Type 2 Inflammatory Asthma
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Pavord, I.D., primary, Israel, E., additional, Szefler, S.J., additional, Brusselle, G., additional, Rabe, K.F., additional, Chen, Z., additional, Altincatal, A., additional, Radwan, A., additional, Pandit-Abid, N., additional, Amin, N., additional, Jacob-Nara, J.A., additional, Rowe, P.J., additional, Deniz, Y.M., additional, Khan, A., additional, Lederer, D.J., additional, Zhang, Y., additional, and Busse, W., additional
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- 2023
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14. Efficacy of Dupilumab in Patients With and Without a Minimally Important Reduction in Fractional Exhaled Nitric Oxide After 2 Weeks of Treatment
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Pavord, I.D., primary, Wechsler, M.E., additional, Busse, W., additional, Domingo Ribas, C., additional, Xia, C., additional, Gall, R., additional, Pandit-Abid, N., additional, Jacob-Nara, J.A., additional, Radwan, A., additional, Rowe, P.J., additional, and Deniz, Y.M., additional
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- 2023
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15. Allergy, asthma, and immunology from infancy to adulthood, 3rd edition. C. Warren Bierman, David S. Pearlman, Gail G. Shapiro, William W. Busse. W. B. Saunders Company 1996, Philadelphia: 805 pp
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Carolyn M. Kercsmar
- Subjects
Pulmonary and Respiratory Medicine ,Allergy ,Psychoanalysis ,business.industry ,Pediatrics, Perinatology and Child Health ,Medicine ,business ,medicine.disease - Published
- 1996
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16. Dupilumab improves exacerbations and lung function irrespective of prior asthma exacerbations: TRAVERSE
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Lommatzsch, M, additional, Papi, A, additional, Castro, M, additional, Busse, W, additional, Langton, D, additional, Korn, S, additional, Xia, C, additional, Soler, X, additional, Pandit-Abid, N, additional, Siddiqui, S, additional, Jacob-Nara, J, additional, Rowe, P, additional, and Deniz, Y, additional
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- 2023
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17. Roflumilast for asthma: Safety findings from a pooled analysis of ten clinical studies
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Chervinsky, P., Meltzer, E.O., Busse, W., Ohta, K., Bardin, P., Bredenbröker, D., and Bateman, E.D.
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- 2015
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18. Roflumilast for asthma: Efficacy findings in placebo-controlled studies
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Meltzer, E.O., Chervinsky, P., Busse, W., Ohta, K., Bardin, P., Bredenbröker, D., and Bateman, E.D.
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- 2015
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19. Multiple retinal isomerizations during the early phase of the bestrhodopsin photoreaction.
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Kaziannis S, Broser M, van Stokkum IHM, Dostal J, Busse W, Munhoven A, Bernardo C, Kloz M, Hegemann P, and Kennis JTM
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- Isomerism, Protein Conformation, Rhodopsin metabolism, Retinaldehyde chemistry, Diterpenes
- Abstract
Bestrhodopsins constitute a class of light-regulated pentameric ion channels that consist of one or two rhodopsins in tandem fused with bestrophin ion channel domains. Here, we report on the isomerization dynamics in the rhodopsin tandem domains of Phaeocystis antarctica bestrhodopsin, which binds all-trans retinal Schiff-base (RSB) absorbing at 661 nm and, upon illumination, converts to the meta-stable P540 state with an unusual 11- cis RSB. The primary photoproduct P682 corresponds to a mixture of highly distorted 11 -cis and 13- cis RSB directly formed from the excited state in 1.4 ps. P673 evolves from P682 in 500 ps and contains highly distorted 13- cis RSB, indicating that the 11- cis fraction in P682 converts to 13- cis . Next, P673 establishes an equilibrium with P595 in 1.2 µs, during which RSB converts to 11- cis and then further proceeds to P560 in 48 µs and P540 in 1.0 ms while remaining 11- cis . Hence, extensive isomeric switching occurs on the early ground state potential energy surface (PES) on the hundreds of ps to µs timescale before finally settling on a metastable 11- cis photoproduct. We propose that P682 and P673 are trapped high up on the ground-state PES after passing through either of two closely located conical intersections that result in 11- cis and 13- cis RSB. Co-rotation of C11=C12 and C13=C14 bonds results in a constricted conformational landscape that allows thermal switching between 11 -cis and 13- cis species of highly strained RSB chromophores. Protein relaxation may release RSB strain, allowing it to evolve to a stable 11- cis isomeric configuration in microseconds., Competing Interests: Competing interests statement:The authors declare no competing interest.
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- 2024
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20. The Functionality of the DC Pair in a Rhodopsin Guanylyl Cyclase from Catenaria anguillulae.
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Fischer P, Schiewer E, Broser M, Busse W, Spreen A, Grosse M, Hegemann P, and Bartl F
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- Light, Models, Molecular, Spectroscopy, Fourier Transform Infrared, Blastocladiomycota enzymology, Blastocladiomycota metabolism, Guanylate Cyclase chemistry, Guanylate Cyclase genetics, Rhodopsin chemistry, Rhodopsin genetics
- Abstract
Rhodopsin guanylyl cyclases (RGCs) belong to the class of enzymerhodopsins catalyzing the transition from GTP into the second messenger cGMP, whereas light-regulation of enzyme activity is mediated by a membrane-bound microbial rhodopsin domain, that holds the catalytic center inactive in the dark. Structural determinants for activation of the rhodopsin moiety eventually leading to catalytic activity are largely unknown. Here, we investigate the mechanistic role of the D283-C259 (DC) pair that is hydrogen bonded via a water molecule as a crucial functional motif in the homodimeric C. anguillulae RGC. Based on a structural model of the DC pair in the retinal binding pocket obtained by MD simulation, we analyzed formation and kinetics of early and late photocycle intermediates of the rhodopsin domain wild type and specific DC pair mutants by combined UV-Vis and FTIR spectroscopy at ambient and cryo-temperatures. By assigning specific infrared bands to S-H vibrations of C259 we are able to show that the DC pair residues are tightly coupled. We show that deprotonation of D283 occurs already in the inactive L state as a prerequisite for M state formation, whereas structural changes of C259 occur in the active M state and early cryo-trapped intermediates. We propose a comprehensive molecular model for formation of the M state that activates the catalytic moiety. It involves light induced changes in bond strength and hydrogen bonding of the DC pair residues from the early J state to the active M state and explains the retarding effect of C259 mutants., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2023. Published by Elsevier Ltd.)
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- 2024
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21. Do Comorbidities Influence the Response to Biologics in Severe Asthma?
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Pelaia C, Pelaia G, and Busse W
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- Humans, Comorbidity, Biological Products therapeutic use, Asthma drug therapy, Asthma epidemiology
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- 2024
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22. MEPOLIZUMAB DECREASES EXACERBATIONS IN PATIENTS WITH ASTHMA AND CHRONIC OBSTRUCTIVE PULMONARY DISEASE: US CLAIMS DATA
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Busse, W., Kalhan, R., Yang, S., Germain, G., Paczkowski, R., Kolterer, S., Igboekwe, E., and Bhatt, S.
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- 2024
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23. MEPOLIZUMAB REDUCES THE RISK OF SYSTEMIC CORTICOSTEROID (SCS)-RELATED COMPLICATIONS COMPARED WITH CHRONIC SCS USE
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Silver, J., Busse, W., Germain, G., Klimek, J., Laliberté, F., and Deb, A.
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- 2024
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24. Dupilumab improves exacerbations and lung function irrespective of prior asthma exacerbations: TRAVERSE
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Papi, A, primary, Castro, M, additional, Busse, W W, additional, Langton, D, additional, Korn, S, additional, Xia, C, additional, Soler, X, additional, Pandit-Abid, N, additional, Siddiqui, S, additional, Jacob-Nara, J A, additional, Rowe, P J, additional, and Deniz, Y, additional
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- 2022
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25. Relation between reduction in fractional exhaled nitric oxide and efficacy in asthma patients treated with dupilumab
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Pavord, I D, primary, Deniz, Y, additional, Casale, T, additional, Corren, J, additional, Fitzgerald, M, additional, Daizadeh, N, additional, Jagerschmidt, A, additional, Dillon, M, additional, Gall, R, additional, Pandit-Abid, N, additional, Siddiqui, S, additional, Jacob-Nara, J A, additional, Rowe, P J, additional, and Busse, W W, additional
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- 2022
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26. Randomised, double-blind, placebo-controlled study to assess long-term effect of dupilumab on prevention of lung function decline (LFD) in patients with uncontrolled moderate-to-severe asthma: ATLAS trial
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De Prado Gomez, L, primary, Pavord, I, additional, Busse, W, additional, Brightling, C E, additional, Wechsler, M E, additional, Rabe, K F, additional, Zhang, M, additional, Xing, J, additional, Jacob-Nara, J A, additional, and J Rowe, P, additional
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- 2022
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27. Effect of dupilumab on asthma control and asthma-related quality of life in patients with uncontrolled, moderate-to-severe type 2 asthma: TRAVERSE OLE study
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Busse, W, primary, Pavord, I D, additional, Corren, J, additional, Menzies-Gow, A, additional, Heffler, E, additional, Msihid, J, additional, Siddiqui, S, additional, Lederer, D J, additional, Hardin, M, additional, Zhang, Y, additional, Khan, A H, additional, Jacob-Nara, J A, additional, Deniz, Y, additional, and Rowe, P J, additional
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- 2022
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28. New Antiallergic Drugs
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Dziadzio, L., Neaville, W., Busse, W., Starke, K., editor, Page, Clive P., editor, and Barnes, Peter J., editor
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- 2004
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29. EUFOREA pocket guide on the diagnosis and management of asthma: An educational and practical tool for general practitioners, non-respiratory physicians, paramedics and patients.
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Diamant Z, Jesenak M, Hanania NA, Heaney LG, Djukanovic R, Ryan D, Quirce S, Backer V, Gaga M, Pavord I, Antolín-Amérigo D, Assaf S, Bakakos P, Bobcakova A, Busse W, Kappen J, Loukides S, van Maaren M, Panzner P, Pite H, Spanevello A, Stenberg H, Striz I, Thio B, Vasakova MK, Conti D, Fokkens W, Lau S, Scadding GK, Van Staeyen E, Hellings PW, and Bjermer L
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- Humans, Paramedics, Educational Status, Patients, General Practitioners, Asthma diagnosis, Asthma therapy
- Abstract
Competing Interests: Declaration of competing interest ZD: received consultancy fees/lecture fees/fees for attending advisory boards from ALK, Antabio, Foresee Pharmaceuticals, GlaxoSmithKline, Hippo-Dx, QPS-Netherlands, Sanofi-Genzyme; she served as Director Respiratory & Allergy at QPS-NL and this CRO received research grants for clinical trials from HAL Allergy, Janssen Research & Development LLC, Patara pharma, Cerbios, Merck Sharp & Dohme, Novartis, Foresee Pharmaceuticals and ERA4TB (IMI-project). MJ: ALK, Stallergenes-Greer, Chiesi, GSK, Pfizer, Novartis, AstraZeneca and SANOFI. NH: Received honoraria for serving as advisor or consultant for GSK, AstraZeneca, Sanofi, Regeneron, Amgen, Genentech, Novartis and Teva. His institution received research grant support of his behalf from GSK, Genentech, Sanofi, Teva, Novartis, and AstraZeneca. LH: Has received grant funding, participated in advisory boards and given lectures at meetings supported by Amgen, AstraZeneca, Boehringer Ingelheim, Chiesi, Circassia, Hoffmann la Roche, GlaxoSmithKline, Novartis, Theravance, Evelo Biosciences, Sanofi, and Teva; he has received grants from MedImmune, Novartis UK, Roche/ Genentech Inc, and Glaxo Smith Kline, Amgen, Genentech/Hoffman la Roche, Astra Zeneca, MedImmune, Glaxo Smith Kline, Aerocrine and Vitalograph; he has received sponsorship for attending international scientific meetings from AstraZeneca, Boehringer Ingelheim, Chiesi, GSK and Napp Pharmaceuticals; he has also taken part in asthma clinical trials sponsored by AstraZeneca, Boehringer Ingelheim, Hoffmann la Roche, and GlaxoSmithKline for which his institution received remuneration; he is the Academic Lead for the Medical Research Council Stratified Medicine UK Consortium in Severe Asthma which involves industrial partnerships with a number of pharmaceutical companies including Amgen, AstraZeneca, Boehringer Ingelheim, GlaxoSmithKline, Hoffmann la Roche, and Janssen. RD: Declares consulting fees from Synairgen, Sanofi and Galapagos, lecture fees from GSK, AZ and Airways Vista and he holds shares from Synairgen. DR: No COIs related to this work. SQ: ALK, Allergy Therapeutics, AstraZeneca, Chiesi, GSK, Leti, Mundipharma, Novartis, Sanofi-Genzyme, Teva. VB: Has worked as advisor, supervisor, investigator of pharmaceutical studies, unrestricted grants, and others with: AstraZeneca, GSK, MSD & Shering Plough, ALK-Abello; Chiesi,Novartis, Pharmaxis, Pfizer, Boehringer Ingelheim, Aerocrine, Teva, Sanofi, Birk NPC as. MG: No COIs related to this work. IP: In the last 5 years IDP has received speaker’s honoraria for speaking at sponsored meetings from Astra Zeneca, Boehringer Ingelheim, Aerocrine, Almirall, Novartis, Teva, Chiesi, Sanofi/Regeneron, Menarini and GSK and payments for organising educational events from AZ, GSK, Sanofi/Regeneron and Teva. He has received honoraria for attending advisory panels with Genentech, Sanofi/ Regeneron, Astra Zeneca, Boehringer Ingelheim, GSK, Novartis, Teva, Merck, Circassia, Chiesi and Knopp and payments to support FDA approval meetings from GSK. He has received sponsorship to attend international scientific meetings from Boehringer Ingelheim, GSK, AstraZeneca, Teva and Chiesi. He has received a grant from Chiesi to support a phase 2 clinical trial in Oxford. DAA: Has received honoraria as grants/contracts from Sociedad Española de Alergología e Inmunología Clínica (SEAIC), as consulting fees from ALK-Abelló, AstraZeneca, Chiesi and Gebro, as speaker from AstraZeneca, Chiesi, Gebro, GSK, Leti Pharma, Mundipharma, Novartis, Roxall, Sanofi. AS: GSK support for an asthma biologic clinical trial 2021-ongoing. PB: Has received honoraria for presentations and consultancy fees from AstraZeneca, Boehringer Ingelheim, Chiesi, ELPEN, GSK, Menarini, Novartis, Sanofi, and Gilead. AB: Takeda, Novartis, Viatris, ALK, Zentiva, MERCK, Stallergenes Greer, Ewopharma, Astra Zeneca, Chiesi, S&D Pharma, Mundipharma, Berlin Chemie. WB: GlaxoSmithKline, Sanofi, Regeneron. JK: Grants and/or personal fees from ALK, Chiesi, GSK, Novartis, AstraZeneca, Sanofi, Boerhinger, Teva, Viatris, Stallergen, Abbot, all outside the submitted work. SL: Honorarium AstraZeneka, GSK, Chiesi Hellas, Sanofi, Elpen, Menarini, Guidoti. MVM: No COIs related to this work. PP: ALK, AstraZeneca, Stallergenes. HP: No COIs related to this work. AS: Reports lecture fees and/or consultancies from AstraZeneca, Chiesi, B.I., GSK, Merck, Novartis, Zambon, Sanofi. HS: No COIs related to this work. IS: No COIs related to this work. BT: No COIs related to this work. MKV: GlaxoSmithKline, AstraZeneca. Diego Conti: No COIs related to this work. WF: The department of Otorhinolaryngology of the Amsterdam University Medical centre, location AMC received grants for research in Rhinology from: ALK, AllergyTherapeutics, Novartis, EU, GSK, MYLAN, Sanofi-Aventis, and Zon-MW; personal COIs: for consultation and/or speaker fees from Dianosic, GSK, Novartis and Sanofi-Aventis/Regeneron. SL: Advisory Board Sanof-Aventis, GSK and Leo-Pharma. Honoraria by DBV Technologies, Allergopharma, Leti, Nutricia, Sanofi-Aventis. GKS: Honoraria for articles, speaker and advisory boards: ALK, AstraZeneca, Capnia, Church & Dwight, Circassia, Noucor, GSK, Meda/Mylan/Viatris, Merck, Sanofi- Regeneron, Stallergenes. Scientific Chief Editor, Rhinology Section, Frontiers in Allergy. Board Member, Lead for Allergic Rhinitis, EUFOREA. Chair of Data Monitoring Board for Paediatric AR trials of HDM SLIT. EVS: No COIs related to this work. PH: Recipient of research grants, honoraria and/or lecture fees of Sanofi, Regeneron, Viatris, GSK, and Novartis. LB: No COIs related to this work.
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- 2023
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30. Diversity of rhodopsin cyclases in zoospore-forming fungi.
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Broser M, Busse W, Spreen A, Reh M, Bernal Sierra YA, Hwang S, Utesch T, Sun H, and Hegemann P
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- Animals, Photoreceptor Cells, Light, Guanylate Cyclase genetics, Mammals, Rhodopsin genetics, Retina
- Abstract
Light perception for orientation in zoospore-forming fungi is linked to homo- or heterodimeric rhodopsin-guanylyl cyclases (RGCs). Heterodimeric RGCs, first identified in the chytrid Rhizoclosmatium globosum , consist of an unusual near-infrared absorbing highly fluorescent sensitizer neorhodopsin (NeoR) that is paired with a visual light-absorbing rhodopsin responsible for enzyme activation. Here, we present a comprehensive analysis of the distribution of RGC genes in early-branching fungi using currently available genetic data. Among the characterized RGCs, we identified red-sensitive homodimeric RGC variants with maximal light activation close to 600 nm, which allow for red-light control of GTP to cGMP conversion in mammalian cells. Heterodimeric RGC complexes have evolved due to a single gene duplication within the branching of Chytridiales and show a spectral range for maximal light activation between 480 to 600 nm. In contrast, the spectral sensitivity of NeoRs is reaching into the near-infrared range with maximal absorption between 641 and 721 nm, setting the low energy spectral edge of rhodopsins so far. Based on natural NeoR variants and mutational studies, we reevaluated the role of the counterion-triad proposed to cause the extreme redshift. With the help of chimera constructs, we disclose that the cyclase domain is crucial for functioning as homo- or heterodimers, which enables the adaptation of the spectral sensitivity by modular exchange of the photosensor. The extreme spectral plasticity of retinal chromophores in native photoreceptors provides broad perspectives on the achievable spectral adaptation for rhodopsin-based molecular tools ranging from UVB into the near-infrared.
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- 2023
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31. Lanthanide-Silicide Films on Silicon Surfaces
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Dähne, M., Vandré, S., Preinesberger, C., Becker, S. K., Busse, W., Kalka, T., and Kramer, Bernhard, editor
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- 2001
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32. Is diet partly responsible for differences in COVID-19 death rates between and within countries?
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Bousquet J., Anto J. M., Iaccarino G., Czarlewski W., Haahtela T., Anto A., Akdis C. A., Blain H., Canonica G. W., Cardona V., Cruz A. A., Illario M., Ivancevich J. C., Jutel M., Klimek L., Kuna P., Laune D., Larenas-Linnemann D., Mullol J., Papadopoulos N. G., Pfaar O., Samolinski B., Valiulis A., Yorgancioglu A., Zuberbier T., Abdul Latiff A. H., Abdullah B., Aberer W., Abusada N., Adcock I., Afani A., Agache I., Aggelidis X., Agustin J., Akdis C., Akdis M., Al-Ahmad M., Al-Zahab Bassam A., Aldrey-Palacios O., Alvarez Cuesta E., Alzaabi A., Amad S., Ambrocio G., Annesi-Maesano I., Ansotegui I., Anto J., Arshad H., Artesani M. C., Asayag E., Avolio F., Azhari K., Baiardini I., Bajrovic N., Bakakos P., Bakeyala Mongono S., Balotro-Torres C., Barba S., Barbara C., Barbosa E., Barreto B., Bartra J., Bateman E. D., Battur L., Bedbrook A., Bedolla Barajas M., Beghe B., Bel E., Ben Kheder A., Benson M., Berghea C., Bergmann K. -C., Bernstein D., Bewick M., Bialek S., Bialoszewski A., Bieber T., Billo N., Bilo M. B., Bindslev-Jensen C., Bjermer L., Bochenska Marciniak M., Bond C., Boner A., Bonini M., Bonini S., Bosnic-Anticevich S., Bosse I., Botskariova S., Bouchard J., Boulet L. -P., Bourret R., Bousquet P., Braido F., Briggs A., Brightling C., Brozek J., Buhl R., Bumbacea R., Burguete Cabanas M. T., Bush A., Busse W. W., Buters J., Caballero-Fonseca F., Calderon M. A., Calvo M., Camargos P., Camuzat T., Cano A., Capriles-Hulett A., Caraballo L., Carlsen K. -H., Caro J., Carr W., Carreon-Asuncion F., Carriazo A. M., Casale T., Castor M. A., Castro E., Cecchi L., Cepeda Sarabia A., Chandrasekharan R., Chang Y. -S., Chato-Andeza V., Chatzi L., Chatzidaki C., Chavannes N. H., Chen Y., Cheng L., Chivato T., Chkhartishvili E., Christoff G., Chrystyn H., Chu D. K., Chua A., Chuchalin A., Chung K. 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H., Chen, Y., Cheng, L., Chivato, T., Chkhartishvili, E., Christoff, G., Chrystyn, H., Chu, D. K., Chua, A., Chuchalin, A., Chung, K. F., Ciceran, A., Cingi, C., Ciprandi, G., Cirule, I., Coelho, A. C., Constantinidis, J., Correia De Sousa, J., Costa, E., Costa, D., Costa Dominguez, M. D. C., Coste, A., Cox, L., Cullen, J., Custovic, A., Cvetkovski, B., D'Amato, G., Da Silva, J., Dahl, R., Dahlen, S. -E., Daniilidis, V., Darjazini Nahhas, L., Darsow, U., De Blay, F., De Guia, E., De Los Santos, C., De Manuel Keenoy, E., De Vries, G., Deleanu, D., Demoly, P., Denburg, J., Devillier, P., Didier, A., Dimou, M., Dinh-Xuan, A. T., Djukanovic, R., Dokic, D., Dominguez Silva, M. G., Douagui, H., Douladiris, N., Doulaptsi, M., Dray, G., Dubakiene, R., Durham, S., Dykewicz, M., Ebo, D., Edelbaher, N., Eklund, P., El-Gamal, Y., El-Sayed, Z. A., El-Sayed, S. S., El-Seify, M., Emuzyte, R., Enecilla, L., Espinoza, H., Espinoza Contreras, J. G., Farrell, J., Fernandez, L., Fink Wagner, A., Fiocchi, A., Fokkens, W. J., Fontaine, J. -F., Forastiere, F., Fuentes Perez, J. M., Gaerlan-Resureccion, E., Gaga, M., Galvez Romero, J. L., Gamkrelidze, A., Garcia, A., Garcia Cobas, C. Y., Garcia Cruz, M. D. L. L. H., Gayraud, J., Gemicioglu, B., Genova, S., Gereda, J., Gerth Van Wijk, R., Gomez, M., Gonzalez Diaz, S., Gotua, M., Grigoreas, C., Grisle, I., Guidacci, M., Guldemond, N., Gutter, Z., Guzman, A., Halloum, R., Hamelmann, E., Hammadi, S., Harvey, R., Heinrich, J., Hejjaoui, A., Hellquist-Dahl, B., Hernandez Velazquez, L., Hew, M., Hossny, E., Howarth, P., Hrubisko, M., Huerta Villalobos, Y. R., Humbert, M., Hyland, M., Ibrahim, M., Ilyina, N., Irani, C., Ispayeva, Z., Jares, E., Jarvis, D., Jassem, E., Jenko, K., Jimeneracruz Uscanga, R. D., Johnston, S., Joos, G., Jost, M., Julge, K., Jung, K. -S., Just, J., Kaidashev, I., Kalayci, O., Kalyoncu, F., Kapsali, J., Kardas, P., Karjalainen, J., Kasala, C. A., Katotomichelakis, M., Kazi, B., Keil, T., Keith, P., Khaitov, M., Khaltaev, N., Kim, Y. -Y., Kleine-Tebbe, J., Koffi N'Goran, B., Kompoti, E., Kopac, P., Koppelman, G., Koren Jeverica, A., Kosnik, M., Kostov, K. V., Kowalski, M. L., Kralimarkova, T., Kramer Vrscaj, K., Kraxner, H., Kreft, S., Kritikos, V., Kudlay, D., Kull, I., Kupczyk, M., Kvedariene, V., Kyriakakou, M., Lalek, N., Lane, S., Latiff, A., Lau, S., Lavrut, J., Le, L., Lessa, M., Levin, M., Li, J., Lieberman, P., Liotta, G., Lipworth, B., Liu, X., Lobo, R., Lodrup Carlsen, K. C., Lombardi, C., Louis, R., Loukidis, S., Lourenco, O., Luna Pech, J. A., Madjar, B., Magnan, A., Mahboub, B., Mair, A., Mais, Y., Maitland Van Der Zee, A. -H., Makela, M., Makris, M., Malling, H. -J., Mandajieva, M., Manning, P., Manousakis, M., Maragoudakis, P., Marshall, G., Martinsmartins, P., Masjedi, M. R., Maspero, J. F., Matta Campos, J. J., Maurer, M., Mavale-Manuel, S., Meco, C., Melen, E., Melo-Gomes, E., Meltzer, E. O., Menditto, E., Menzies-Gow, A., Merk, H., Michel, J. -P., Miculinic, N., Midao, L., Mihaltan, F., Mikael, K., Mikos, N., Milenkovic, B., Mitsias, D., Moalla, B., Moda, G., Mogica Martinez, M. D., Mohammad, Y., Moin, M., Molimard, M., Momas, I., Monaco, A., Montefort, S., Mora, D., Morais-Almeida, M., Mosges, R., Mostafa, B. E., Munter, L., Muraro, A., Murray, R., Mustakov, T., Naclerio, R., Nadif, R., Nakonechna, A., Namazova-Baranova, L., Navarro-Locsin, G., Neffen, H., Nekam, K., Neou, A., Nicod, L., Niederberger-Leppin, V., Niedoszytko, M., Nieto, A., Novellino, E., Nunes, E., Nyembue, D., O'Hehir, R., Odjakova, C., Ohta, K., Okamoto, Y., Okubo, K., Oliver, B., Onorato, G. L., Orru, M. P., Ouedraogo, S., Ouoba, K., Paggiaro, P. L., Pagkalos, A., Palaniappan, S. P., Pali-Scholl, I., Palkonen, S., Palmer, S., Panaitescu Bunu, C., Panzner, P., Papanikolaou, V., Papi, A., Paralchev, B., Paraskevopoulos, G., Park, H. S., Passalacqua, G., Patella, V., Pavord, I., Pawankar, R., Pedersen, S., Peleve, S., Pereira, A., Perez, T., Pham-Thi, N., Pigearias, B., Pin, I., Piskou, K., Pitsios, C., Pitsios, K., Plavec, D., Poethig, D., Pohl, W., Poplas Susic, A., Popov, T. A., Portejoie, F., Potter, P., Poulsen, L., Prados-Torres, A., Prarros, F., Price, D., Prokopakis, E., Puy, R., Rabe, K., Raciborski, F., Ramos, J., Recto, M. T., Reda, S. M., Regateiro, F., Reider, N., Reitsma, S., Repka-Ramirez, S., Rimmer, J., Rivero Yeverino, D., Rizzo, J. A., Robalo-Cordeiro, C., Roberts, G., Roche, N., Rodriguez Gonzalez, M., Rodriguez Zagal, E., Rolland, C., Roller-Wirnsberger, R., Roman Rodriguez, M., Romano, A., Rombaux, P., Romualdez, J., Rosado-Pinto, J., Rosario, N., Rosenwasser, L., Rottem, M., Rouadi, P., Rovina, N., Rozman Sinur, I., Ruiz, M., Ruiz Segura, L. T., Ryan, D., Sagara, H., Sakai, D., Sakurai, D., Saleh, W., Salimaki, J., Salina, H., Samitas, K., Sanchez Coronel, M. G., Sanchez-Borges, M., Sanchez-Lopez, J., Sarafoleanu, C., Sarquis Serpa, F., Sastre-Dominguez, J., Scadding, G., Scheire, S., Schmid-Grendelmeier, P., Schuhl, J. F., Schunemann, H., Schvalbova, M., Scichilone, N., Sepulveda, C., Serrano, E., Sheikh, A., Shields, M., Shishkov, V., Siafakas, N., Simeonov, A., Simons, E. F., Sisul, J. C., Sitkauskiene, B., Skrindo, I., Soklic Kosak, T., Sole, D., Sooronbaev, T., Soto-Martinez, M., Sova, M., Spertini, F., Spranger, O., Stamataki, S., Stefanaki, L., Stellato, C., Stelmach, R., Sterk, P., Strandberg, T., Stute, P., Subramaniam, A., Suppli Ulrik, C., Sutherland, M., Sylvestre, S., Syrigou, A., Taborda Barata, L., Takovska, N., Tan, R., Tan, F., Tan, V., Tang, I. P., Taniguchi, M., Tannert, L., Tattersall, J., Teixeira, M. D. C., Thijs, C., Thomas, M., To, T., Todo-Bom, A. M., Togias, A., Tomazic, P. -V., Toppila-Salmi, S., Toskala, E., Triggiani, M., Triller, N., Triller, K., Tsiligianni, I., Ulmeanu, R., Urbancic, J., Urrutia Pereira, M., Vachova, M., Valdes, F., Valenta, R., Valentin Rostan, M., Valero, A., Vallianatou, M., Valovirta, E., Van Eerd, M., Van Ganse, E., Van Hage, M., Vandenplas, O., Vasankari, T., Vassileva, D., Ventura, M. T., Vera-Munoz, C., Vicheva, D., Vichyanond, P., Vidgren, P., Viegi, G., Vogelmeier, C., Von Hertzen, L., Vontetsianos, T., Vourdas, D., Wagenmann, M., Walker, S., Wallace, D., Wang, D. Y., Waserman, S., Wickman, M., Williams, S., Williams, D., Wilson, N., Woo, K., Wright, J., Wroczynski, P., Xepapadaki, P., Yakovliev, P., Yamaguchi, M., Yan, K., Yap, Y. Y., Yawn, B., Yiallouros, P., Yoshihara, S., Young, I., Yusuf, O. B., Zaidi, A., Zaitoun, F., Zar, H., Zernotti, M., Zhang, L., Zhong, N., Zidarn, M., Zubrinich, C., University of Zurich, Bousquet, Jean, Charité - UniversitätsMedizin = Charité - University Hospital [Berlin], Berlin Institute of Health (BIH), Contre les MAladies Chroniques pour un VIeillissement Actif en Languedoc-Roussillon (MACVIA-LR), Université Montpellier 1 (UM1)-Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre Hospitalier Universitaire de Nîmes (CHU Nîmes)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-European Innovation Partnership on Active and Healthy Ageing Reference Site (EIP on AHA), Commission Européenne-Commission Européenne-Organisation Mondiale de la Santé / World Health Organization Office (OMS / WHO), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Center for Research in Environmental Epidemiology (CREAL), Universitat Pompeu Fabra [Barcelona] (UPF)-Catalunya ministerio de salud, IMIM-Hospital del Mar, Generalitat de Catalunya, Universitat Pompeu Fabra [Barcelona] (UPF), CIBER de Epidemiología y Salud Pública (CIBERESP), 'Federico II' University of Naples Medical School, Medical Consulting Czarlewski, Helsingin yliopisto = Helsingfors universitet = University of Helsinki, Swiss Institute of Allergy and Asthma Research (SIAF), Universität Zürich [Zürich] = University of Zurich (UZH), Euromov (EuroMov), Université de Montpellier (UM), IRCCS Humanitas Research Hospital, 20089 Rozzano, Italy., Vall d'Hebron University Hospital [Barcelona], ProAR – Nucleo de Excelencia em Asma, Universidade Federal da Bahia (UFBA), Global Alliance Against Chronic Respiratory Diseases (GARD-WHO), Division for Health Innovation, Servicio de Alergia e ImmunologiaBuenos Aires (Clinica Santa Isabel), Wrocław Medical University, Center for Rhinology and Allergology Wiesbaden, University Hospital Mannheim, Barlicki University Hospital, KYomed INNOV [Montpellier], Hospital Medica Sur [Mexico City, Mexico], Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Universitat de Barcelona (UB), Centro de Investigación Biomédica en Red Enfermedades Respiratorias (CIBERES), Royal Manchester Children's Hospital, University of Manchester [Manchester], General Children's Hospital of Athens P & A Kyriakou, Philipps Universität Marburg = Philipps University of Marburg, Medical University of Warsaw - Poland, Vilnius University [Vilnius], Manisa Celal Bayar University, and Salvy-Córdoba, Nathalie
- Subjects
BLOOD-PRESSURE ,Review ,Angiotensin-converting enzyme ,Antioxidant ,Coronavirus ,Diet ,Food ,law.invention ,Dietary interventions ,0302 clinical medicine ,[SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases ,10183 Swiss Institute of Allergy and Asthma Research ,law ,Medicine and Health Sciences ,Immunology and Allergy ,Medicine ,030212 general & internal medicine ,[SDV.MHEP.ME] Life Sciences [q-bio]/Human health and pathology/Emerging diseases ,[SDV.MHEP.ME]Life Sciences [q-bio]/Human health and pathology/Emerging diseases ,education.field_of_study ,Mortality rate ,3. Good health ,[SDV.MHEP.MI] Life Sciences [q-bio]/Human health and pathology/Infectious diseases ,2723 Immunology and Allergy ,Angiotensin-converting enzyme, Antioxidant, Coronavirus, Diet, Food ,Pulmonary and Respiratory Medicine ,2019-20 coronavirus outbreak ,Coronavirus disease 2019 (COVID-19) ,Coronaviru ,Immunology ,Population ,610 Medicine & health ,COVID-19 ,Settore MED/10 - Malattie Dell'Apparato Respiratorio ,03 medical and health sciences ,Environmental health ,population ,angiotensin-converting enzyme ,Quarantine ,education ,2403 Immunology ,ANTIHYPERTENSIVE PEPTIDES ,business.industry ,RC581-607 ,GENE ,POLYMORPHISM ,[SDV.AEN] Life Sciences [q-bio]/Food and Nutrition ,030228 respiratory system ,2740 Pulmonary and Respiratory Medicine ,Immunologic diseases. Allergy ,business ,[SDV.AEN]Life Sciences [q-bio]/Food and Nutrition ,Regional differences ,Coronavirus Infections - Abstract
Reported COVID-19 deaths in Germany are relatively low as compared to many European countries. Among the several explanations proposed, an early and large testing of the population was put forward. Most current debates on COVID-19 focus on the differences among countries, but little attention has been given to regional differences and diet. The low-death rate European countries (e.g. Austria, Baltic States, Czech Republic, Finland, Norway, Poland, Slovakia) have used different quarantine and/or confinement times and methods and none have performed as many early tests as Germany. Among other factors that may be significant are the dietary habits. It seems that some foods largely used in these countries may reduce angiotensin-converting enzyme activity or are anti-oxidants. Among the many possible areas of research, it might be important to understand diet and angiotensin-converting enzyme-2 (ACE2) levels in populations with different COVID-19 death rates since dietary interventions may be of great benefit.
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- 2020
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33. Tafelen en stoelen : Over de Amstelveense snoeiwijze
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Busse, W. and Busse, W.
- Abstract
De Amstelveense heemparken worden gekenmerkt door veel doorkijkjes en een prachtige sfeer. Je treft er, naast open plekken, ook grillige bomen, struiken en een rijke ondergroei van kruiden aan. Achter dat natuurlijke effect zit een intensief en uitgekiend beheer. Door de manier van snoeien worden grillige vormen geaccentueerd, vallen er geen ‘gaten’ in de begroeiing en valt er voldoende licht op de bodem voor de ondergroei. In dit artikel meer over de ‘Amstelveense snoei’.
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- 2022
34. Exploring the Effect of Anti-IL5 Therapy on Sputum Eosinophils in Children with Asthma
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Wilson, G., primary, Liu, Q., additional, Knight, J., additional, Visness, C., additional, Villarreal, M., additional, Gill, M., additional, Gruchalla, R.S., additional, Liu, A.H., additional, Kattan, M., additional, Hershey, G.N., additional, Togias, A., additional, Becker, P.M., additional, Altman, M.C., additional, Busse, W., additional, Jackson, D.J., additional, Montgomery, R., additional, and Chupp, G., additional
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- 2022
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35. Relation Between Fractional Exhaled Nitric Oxide Reductions and Efficacy Outcomes in Patients with Asthma Treated with Dupilumab
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Busse, W., primary, Pavord, I.D., additional, Deniz, Y., additional, Casale, T.B., additional, Wenzel, S.E., additional, Corren, J., additional, Fitzgerald, J.M., additional, Daizadeh, N., additional, Jagerschmidt, A., additional, Harel, S., additional, Ortiz, B., additional, Djandji, M., additional, Crikelair, N., additional, Jacob-Nara, J.A., additional, and Rowe, P.J., additional
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- 2022
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36. Discussion: “Water-Lubricated Soft-Rubber Bearings” (Busse, W. F., and Denton, W. H., 1932, Trans. ASME, 54(5), pp. 3–9)
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Sharp, R. E. B., primary
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- 1932
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37. Design and Operating System of Floating Waste Treatment Facility in Belakang Padang
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Ali, M, primary, Zaman, M B, additional, Prastowo, H, additional, Pitana, T, additional, Priyanta, D, additional, Siswantoro, N, additional, and Busse, W, additional
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- 2022
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38. Impact of protein-chromophore interaction on the retinal excited state and photocycle of Gloeobacter rhodopsin: role of conserved tryptophan residues.
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Misra R, Das I, Dér A, Steinbach G, Shim JG, Busse W, Jung KH, Zimányi L, and Sheves M
- Abstract
The function of microbial as well as mammalian retinal proteins ( aka rhodopsins) is associated with a photocycle initiated by light excitation of the retinal chromophore of the protein, covalently bound through a protonated Schiff base linkage. Although electrostatics controls chemical reactions of many organic molecules, attempt to understand its role in controlling excited state reactivity of rhodopsins and, thereby, their photocycle is scarce. Here, we investigate the effect of highly conserved tryptophan residues, between which the all- trans retinal chromophore of the protein is sandwiched in microbial rhodopsins, on the charge distribution along the retinal excited state, quantum yield and nature of the light-induced photocycle and absorption properties of Gloeobacter rhodopsin (GR). Replacement of these tryptophan residues by non-aromatic leucine (W222L and W122L) or phenylalanine (W222F) does not significantly affect the absorption maximum of the protein, while all the mutants showed higher sensitivity to photobleaching, compared to wild-type GR. Flash photolysis studies revealed lower quantum yield of trans - cis photoisomerization in W222L as well as W222F mutants relative to wild-type. The photocycle kinetics are also controlled by these tryptophan residues, resulting in altered accumulation and lifetime of the intermediates in the W222L and W222F mutants. We propose that protein-retinal interactions facilitated by conserved tryptophan residues are crucial for achieving high quantum yield of the light-induced retinal isomerization, and affect the thermal retinal re-isomerization to the resting state., Competing Interests: The authors declare no competing financial interest., (This journal is © The Royal Society of Chemistry.)
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- 2023
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39. How Has the Biologic Revolution Improved Patient Care?
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Guilbert TW and Busse W
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- Humans, Patient Care, Biological Products therapeutic use
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- 2023
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40. P067 DUPILUMAB LEADS TO CLINICAL ASTHMA REMISSION INDICATIVE OF COMPREHENSIVE IMPROVEMENT IN PATIENTS WITH ASTHMA
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Pavord, I., primary, Busse, W., additional, Israel, E., additional, Szefler, S., additional, Chen, Z., additional, Khan, A., additional, Lederer, D., additional, and Zhang, Y., additional
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- 2021
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41. P184 IMPACT OF DUPILUMAB ON SLEEP/FUNCTION SCORES IN PATIENTS WITH CHRONIC RHINOSINUSITIS WITH NASAL POLYPS
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Busse, W., primary, Wellman, A., additional, Bachert, C., additional, Siddiqui, S., additional, Zhang, H., additional, Khan, A., additional, Jacob-Nara, J., additional, Rowe, P., additional, and Deniz, Y., additional
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- 2021
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42. P183 DUPILUMAB IMPROVES CRSWNP/ASTHMA OUTCOMES IN PATIENTS WITH CRSWNP AND COMORBID ASTHMA IRRESPECTIVE OF ASTHMA CHARACTERISTICS
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Busse, W., primary, Pavord, I., additional, Siddiqui, S., additional, Khan, A., additional, Praestgaard, A., additional, Nash, S., additional, Jacob-Nara, J., additional, Rowe, P., additional, and Deniz, Y., additional
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- 2021
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43. P070 EFFICACY OF BIOLOGIC THERAPIES IN PATIENTS WITH SEVERE, UNCONTROLLED ASTHMA STRATIFIED BY BLOOD EOSINOPHIL COUNT
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Busse, W., primary, FitzGerald, M., additional, Korn, S., additional, Cook, B., additional, Llanos-Ackert, J., additional, and Ambrose, C., additional
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- 2021
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44. eQTL of bronchial epithelial cells and bronchial alveolar lavage deciphers GWAS-identified asthma genes
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Li, X., Hastie, A. T., Hawkins, G. A., Moore, W. C., Ampleford, E. J., Milosevic, J., Li, H., Busse, W. W., Erzurum, S. C., Kaminski, N., Wenzel, S. E., Meyers, D. A., and Bleecker, E. R.
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- 2015
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45. Effect of Low Temperatures on Germination of Impermeable Seeds
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Busse, W. F.
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- 1930
46. Some Effects of Low Temperatures on Seeds
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Busse, W. F. and Burnham, C. R.
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- 1930
47. Supplement to: Randomized trial of omalizumab (anti-IgE) for asthma in inner-city children
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Busse, W W, Morgan, W J, and Gergen, P J
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- 2011
48. Once-daily fluticasone furoate 50 mcg in mild-to-moderate asthma: a 24-week placebo-controlled randomized trial
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Busse, W. W., Bateman, E. D., OʼByrne, P. M., Lötvall, J., Woodcock, A., Medley, H., Forth, R., and Jacques, L.
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- 2014
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49. Real-World Clinical Characteristics of COVID-19 Patients With or Without Evidence of Allergic Asthma
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Kaner, R.J., primary, Murphy, T.R., additional, Holweg, C., additional, Rajput, Y., additional, Raimundo, K., additional, Seetasith, A., additional, Meyer, C.S., additional, Iqbal, A., additional, and Busse, W., additional
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- 2021
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50. Bronchial Allergen Challenge Induces IL-17A and Associated Gene Expression Changes Related to fMRI Activation in the Amygdala and Insula
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Rosenkranz, M.A., primary, Dill-McFarland, K., additional, Esnault, S., additional, Jarjour, N.N., additional, Busse, W., additional, and Altman, M.C., additional
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- 2021
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- View/download PDF
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