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3. Human leptospirosis trends, the Netherlands, 1925-2008

Author

Goris, Marga G.A., Boer, Kimberly R., Duarte, Tamara A.T.E., Kliffen, Suzanne J., and Hartskeerl, Rudy A.

Subjects
Leptospirosis -- Causes of -- Diagnosis -- Demographic aspects -- Research, Prevalence studies (Epidemiology), Health
Abstract

Leptospirosis is a zoonotic disease caused by infection with Leptospira spp. bacteria (1). Pathogenic leptospires live in the kidneys of many mammalian hosts, including rodents, insectivores, and livestock. Leptospires are [...]

Published
2013
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8. Comparison of on-demand versus planned relaparotomy strategy in patients with severe peritonitis

Author

van Ruler, Oddeke, Mahler, Cecilia W., Boer, Kimberly R., Reuland, E. Ascelijn, Gooszen, Hein G., Opmeer, Brent C., de Graaf, Peter W., Lamme, Bas, Gerhards, Michael F., Steller, E. Philip, van Till, J. W. Olivier, de Borgie, Corianne J. A. M., Gouma, Dirk J., Reitsma, Johannes B., and Boermeester, Marja A.

Subjects
Company business management, Peritonitis -- Patient outcomes, Peritonitis -- Care and treatment, Medical care -- Utilization, Medical care -- Management, Medical care, Cost of
Abstract

A study to compare patient outcome, health care utilization, and costs of on-demand and planned relaparotomy in patients suffering from severe peritonitis was conducted. Results found that in both types of treatment, the mortality rate was the same but observed a substantial reduction in relaparotomies, health care utilization, and medical costs.

Published
2007

11. Strengthening evidence-based healthcare in Africa

Author

Forland, Frode, Rohwer, Anke C, Klatser, Paul, Boer, Kimberly, Mayanja-Kizza, Harriet, Joseph, Ntaganira, Sanctus, Musafiri, Jaffu, Chilongola, Tamara, Kredo, Charles, Okwundu, Anke, Rohwer, Gabriel, Ndayisaba, Twungubumwe, Novat, Harriet, Mayanja-Kizza, Exnevia, Gomo, Gertrude, Kalanda, Admasu, Tenna, Ephrem, Abebe, Omar, Abdulwadud, Isabelle, Wachsmuth-Huguet, Kimberly, Boer, Masja, Straetemans, and Frode, Forland

Published
2013
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17. Systematic review and meta-analysis: rapid diagnostic tests versus placental histology, microscopy and PCR for malaria in pregnant women

Author

Kattenberg Johanna H, Ochodo Eleanor A, Boer Kimberly R, Schallig Henk DFH, Mens Petra F, and Leeflang Mariska MG

Subjects
Malaria, pregnancy, malaria in pregnancy (MiP), rapid diagnostic tests (RDTs), PCR, microscopy, histology, diagnostic test accuracy, systematic review, meta-analysis, Arctic medicine. Tropical medicine, RC955-962, Infectious and parasitic diseases, RC109-216
Abstract

Abstract Background During pregnancy, malaria infection with Plasmodium falciparum or Plasmodium vivax is related to adverse maternal health and poor birth outcomes. Diagnosis of malaria, during pregnancy, is complicated by the absence or low parasite densities in peripheral blood. Diagnostic methods, other than microscopy, are needed for detection of placental malaria. Therefore, the diagnostic accuracy of rapid diagnostic tests (RDTs), detecting antigen, and molecular techniques (PCR), detecting DNA, for the diagnosis of Plasmodium infections in pregnancy was systematically reviewed. Methods MEDLINE, EMBASE and Web of Science were searched for studies assessing the diagnostic accuracy of RDTs, PCR, microscopy of peripheral and placental blood and placental histology for the detection of malaria infection (all species) in pregnant women. Results The results of 49 studies were analysed in metandi (Stata), of which the majority described P. falciparum infections. Although both placental and peripheral blood microscopy cannot reliably replace histology as a reference standard for placental P. falciparum infection, many studies compared RDTs and PCR to these tests. The proportion of microscopy positives in placental blood (sensitivity) detected by peripheral blood microscopy, RDTs and PCR are respectively 72% [95% CI 62-80], 81% [95% CI 55-93] and 94% [95% CI 86-98]. The proportion of placental blood microscopy negative women that were negative in peripheral blood microscopy, RDTs and PCR (specificity) are 98% [95% CI 95-99], 94% [95% CI 76-99] and 77% [95% CI 71-82]. Based on the current data, it was not possible to determine if the false positives in RDTs and PCR are caused by sequestered parasites in the placenta that are not detected by placental microscopy. Conclusion The findings suggest that RDTs and PCR may have good performance characteristics to serve as alternatives for the diagnosis of malaria in pregnancy, besides any other limitations and practical considerations concerning the use of these tests. Nevertheless, more studies with placental histology as reference test are urgently required to reliably determine the accuracy of RDTs and PCR for the diagnosis of placental malaria. P. vivax-infections have been neglected in diagnostic test accuracy studies of malaria in pregnancy.

Published
2011
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18. Health related quality of life six months following surgical treatment for secondary peritonitis – using the EQ-5D questionnaire

Author

Steller E Philip, Gerhards Michael F, Hesselink Eric J, de Graaf Peter W, Gooszen Hein G, Reuland E Ascelijn, Opmeer Brent C, Mahler Cecilia W, Reitsma Johannes B, van Ruler Oddeke, Boer Kimberly R, Sprangers Mirjam A, Boermeester Marja A, and De Borgie Corianne A

Subjects
Computer applications to medicine. Medical informatics, R858-859.7
Abstract

Abstract Background To compare health related quality of life (HR-QoL) in patients surgically treated for secondary peritonitis to that of a healthy population. And to prospectively identify factors associated with poorer (lower) HR-QoL. Design A prospective cohort of secondary peritonitis patients was mailed the EQ-5D and EQ-VAS 6-months following initial laparotomy. Setting Multicenter study in two academic and seven regional teaching hospitals. Patients 130 of the 155 eligible patients (84%) responded to the HR-QoL questionnaires. Results HR-QoL was significantly worse on all dimensions in peritonitis patients than in a healthy reference population. Peritonitis characteristics at initial presentation were not associated with HR-QoL at six months. A more complicated course of the disease leading to longer hospitalization times and patients with an enterostomy had a negative impact on the mobility (p = 0.02), self-care (p < 0.001) and daily activities: (p = 0.01). In a multivariate analysis for the EQ-VAS every doubling of hospital stay decreases the EQ-VAS by 3.8 points (p = 0.015). Morbidity during the six-month follow-up was not found to be predictive for the EQ-5D or EQ-VAS. Conclusion Six months following initial surgery, patients with secondary peritonitis report more problems in HR-QoL than a healthy reference population. Unfavorable disease characteristics at initial presentation were not predictive for poorer HR-QoL, but a more complicated course of the disease was most predictive of HR-QoL at 6 months.

Published
2007
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19. Pushing the envelope through the Global Financing Facility: potential impact of mobilising additional support to scale-up life-saving interventions for women, children and adolescents in 50 high-burden countries

Author

Chou, Victoria B, primary, Bubb-Humfryes, Oliver, additional, Sanders, Rachel, additional, Walker, Neff, additional, Stover, John, additional, Cochrane, Tom, additional, Stegmuller, Angela, additional, Magalona, Sophia, additional, Von Drehle, Christian, additional, Walker, Damian G, additional, Bonilla-Chacin, Maria Eugenia, additional, and Boer, Kimberly Rachel, additional

Published
2018
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20. The Strength of the Global Financing Facility: Pushing the Global Envelope for Women, Children and Adolescents in the Era of Sustainable Development

Author

Chou, Victoria B., primary, Bubb-Humfryes, Oliver, additional, Sanders, Rachel, additional, Walker, Neff, additional, Stover, John, additional, Cochrane, Tom, additional, Stegmuller, Angela, additional, Magalona, Sophia, additional, Drehle, Christian Von, additional, Walker, Damian G., additional, Bonilla-Chacin, Maria Eugenia, additional, and Boer, Kimberly, additional

Published
2018
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21. Fertility and HIV following universal access to ART in Rwanda: a cross-sectional analysis of Demographic and Health Survey data

Author

Remera, Eric, primary, Boer, Kimberly, additional, Umuhoza, Stella M., additional, Hedt-Gauthier, Bethany L., additional, Thomson, Dana R., additional, Ndimubanzi, Patrick, additional, Kayirangwa, Eugenie, additional, Mutsinzi, Salomon, additional, Bayingana, Alice, additional, Mugwaneza, Placidie, additional, and Koama, Jean Baptiste T., additional

Published
2017
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23. Operating Characteristics of a Tuberculosis Screening Tool for People Living with HIV in Out-Patient HIV Care and Treatment Services, Rwanda

Author

Turinawe, Kenneth, primary, Vandebriel, Greet, additional, Lowrance, David W., additional, Uwinkindi, Francois, additional, Mutwa, Philippe, additional, Boer, Kimberly R., additional, Mutembayire, Grace, additional, Tugizimana, David, additional, Nsanzimana, Sabin, additional, Pevzner, Eric, additional, Howard, Andrea A., additional, and Gasana, Michel, additional

Published
2016
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24. A Mixed Outbreak of Epidemic Typhus Fever and Trench Fever in a Youth Rehabilitation Center: Risk Factors for Illness from a Case-Control Study, Rwanda, 2012

Author

Umulisa, Irenee, primary, Nyatanyi, Thierry, additional, Koama, Jean Baptiste, additional, Rwunganira, Samuel, additional, Condo, Jeanine, additional, Galgalo, Tura, additional, Uwimana, Jean Marie, additional, Muldoon, Katherine A., additional, McQuiston, Jennifer, additional, Habiyaremye, Francois, additional, Muhimpundu, Marie Aimee, additional, Binagwaho, Agnes, additional, Massung, Robert, additional, Boer, Kimberly, additional, Raghunathan, Pratima L., additional, Tongren, Eric, additional, Dahourou, Anicet G., additional, Omolo, Jared, additional, Mills, Edward J., additional, and Gatei, Wangeci, additional

Published
2016
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25. Combination Antiretroviral Therapy for HIV in Rwandan Adults: Clinical Outcomes and Impact on Reproductive Health up to 24 Months

Author

Asiimwe-Kateera, Brenda, primary, Veldhuijzen, Nienke, additional, Balinda, Jean Paul, additional, Rusine, John, additional, Eagle, Sally, additional, Vyankandondera, Joseph, additional, Mugabekazi, Julie, additional, Ondoa, Pascale, additional, Boer, Kimberly, additional, Asiimwe, Anita, additional, Lange, Joep, additional, Reiss, Peter, additional, and van de Wijgert, Janneke, additional

Published
2015
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26. Misleading conclusion

Author

Klatser, Paul, Anthony, Richard, den Hertog, Alice, Leeflang, Mariska, Boer, Kimberly, KIT: Biomedical Research, Amsterdam Public Health, and Epidemiology and Data Science

Published
2010

27. Safety and Effectiveness of Combination Antiretroviral Therapy during the First Year of Treatment in HIV-1 Infected Rwandan Children: A Prospective Study

Author

Mutwa, Philippe R., primary, Boer, Kimberly R., additional, Asiimwe-Kateera, Brenda, additional, Tuyishimire, Diane, additional, Muganga, Narcisse, additional, Lange, Joep M. A., additional, van de Wijgert, Janneke, additional, Asiimwe, Anita, additional, Reiss, Peter, additional, and Geelen, Sibyl P. M., additional

Published
2014
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28. “Let's Talk about Sex”: A Qualitative Study of Rwandan Adolescents' Views on Sex and HIV

Author

Van Nuil, Jennifer Ilo, primary, Mutwa, Philippe, additional, Asiimwe-Kateera, Brenda, additional, Kestelyn, Evelyne, additional, Vyankandondera, Joseph, additional, Pool, Robert, additional, Ruhirimbura, John, additional, Kanakuze, Chantal, additional, Reiss, Peter, additional, Geelen, Sibyl P. M., additional, van de Wijgert, Janneke H., additional, and Boer, Kimberly R., additional

Published
2014
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30. Factors associated with posttraumatic stress symptoms in a prospective cohort of patients after abdominal sepsis:A nomogram

Author

Boer, Kimberly R., Van Ruler, O., Van Emmerik, Arnold A.P., Sprangers, Mirjam A., De Rooij, Sophia E., Vroom, Margreeth B., De Borgie, C. A.J.M., Boermeester, M. A., Reitsma, Johannes B., Boer, K. R., Mahler, C. W., Reuland, E. A., Van Till, J. W.O., Opmeer, B. C., Bossuyt, P. M.M., Schultz, M. J., Sprangers, M. A., Obertop, H., Gouma, D. J., Steller, E. P., Tanis, P., Hart, H., Gerhards, M. F., Guijt, M., Oudemans, H. M., Bosscha, K., Ritchie, E., Vermeer, M., De Graaf, P. W., Van Etten, B., Haazer, C., Salm, E., Lamme, B., Hesselink, E. J., Rommes, H., Oostenbroek, R. J., Te Velde, L., Govaert, G., Ponssen, H. H., Gooszen, H. G., Dinkelman, M. K., Leenen, L. P.H., Pierik, E. G.J.M., Lansink, K. W.W., Bakker, J., Boer, Kimberly R., Van Ruler, O., Van Emmerik, Arnold A.P., Sprangers, Mirjam A., De Rooij, Sophia E., Vroom, Margreeth B., De Borgie, C. A.J.M., Boermeester, M. A., Reitsma, Johannes B., Boer, K. R., Mahler, C. W., Reuland, E. A., Van Till, J. W.O., Opmeer, B. C., Bossuyt, P. M.M., Schultz, M. J., Sprangers, M. A., Obertop, H., Gouma, D. J., Steller, E. P., Tanis, P., Hart, H., Gerhards, M. F., Guijt, M., Oudemans, H. M., Bosscha, K., Ritchie, E., Vermeer, M., De Graaf, P. W., Van Etten, B., Haazer, C., Salm, E., Lamme, B., Hesselink, E. J., Rommes, H., Oostenbroek, R. J., Te Velde, L., Govaert, G., Ponssen, H. H., Gooszen, H. G., Dinkelman, M. K., Leenen, L. P.H., Pierik, E. G.J.M., Lansink, K. W.W., and Bakker, J.

Abstract

Objective: To determine to what extent patients who have survived abdominal sepsis suffer from symptoms of posttraumatic stress disorder (PTSD) and depression, and to identify potential risk factors for PTSD symptoms. Design and setting: PTSD and depression symptoms were measured using the Impact of Events Scale-Revised (IES-R), the Post-Traumatic Symptom Scale 10 (PTSS-10) and the Beck Depression Inventory II (BDI-II). Patients and participants: A total of 135 peritonitis patients were eligible for this study, of whom 107 (80%) patients completed the questionnaire. The median APACHE-II score was 14 (range 12-16), and 89% were admitted to the ICU.Measurements and results: The proportion of patients with "moderate" PTSD symptom scores was 28% (95% CI 20-37), whilst 10% (95% CI 6-17) of patients had "high" PTSD symptom scores. Only 5% (95% CI 2-12) of the patients expressed severe depression symptoms. Factors associated with increased PTSD symptoms in a multivariate ordinal regression model were younger age (0.74 per 10 years older, p = 0.082), length of ICU stay (OR = 1.4 per doubling of duration, p = 0.003) and having some (OR = 4.9, p = 0.06) or many (OR = 55.5, p < 0.001) traumatic memories of the ICU or hospital stay. Conclusion: As many as 38% of patients after abdominal sepsis report elevated levels of PTSD symptoms on at least one of the questionnaires. Our nomogram may assist in identifying patients at increased risk for developing symptoms of PTSD.

Published
2008

32. Low Primary and Secondary HIV Drug-Resistance after 12 Months of Antiretroviral Therapy in Human Immune-Deficiency Virus Type 1 (HIV-1)-Infected Individuals from Kigali, Rwanda

Author

Rusine, John, primary, Asiimwe-Kateera, Brenda, additional, van de Wijgert, Janneke, additional, Boer, Kimberly Rachel, additional, Mukantwali, Enatha, additional, Karita, Etienne, additional, Gasengayire, Agnes, additional, Jurriaans, Suzanne, additional, de Jong, Menno, additional, and Ondoa, Pascale, additional

Published
2013
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37. Living Situation Affects Adherence to Combination Antiretroviral Therapy in HIV-Infected Adolescents in Rwanda: A Qualitative Study

Author

Mutwa, Philippe R., primary, Van Nuil, Jennifer Ilo, additional, Asiimwe-Kateera, Brenda, additional, Kestelyn, Evelyne, additional, Vyankandondera, Joseph, additional, Pool, Robert, additional, Ruhirimbura, John, additional, Kanakuze, Chantal, additional, Reiss, Peter, additional, Geelen, Sibyl, additional, Wijgert, Janneke van de, additional, and Boer, Kimberly R., additional

Published
2013
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39. Health related quality of life six months following surgical treatment for secondary peritonitis - Using the EQ-5D questionnaire

Author

Boer, Kimberly R., van Ruler, Oddeke, Reitsma, Johannes B., Mahler, Cecilia W., Opmeer, Brent C., Reuland, E. Ascelijn, Gooszen, Hein G., de Graaf, Peter W., Hesselink, Eric J., Gerhards, Michael F., Steller, E. P.H., Sprangers, Mirjam A., Boermeester, Marja A., De Borgie, Corianne A., Van Till, J. W.O., Bossuyt, P. M.M., Schultz, M. J., Obertop, H., Gouma, D. J., Tanis, P., Hart, H., Guijt, M., Oudemans, H. M., Bosscha, K., Ritchie, E., Vermeer, M., Van Etten, B., Haazer, C., Salm, E., Rommes, H., Oostenbroek, R. J., te Velde, L., Govaert, G., Ponssen, H. H., Dinkelman, M. K., Leenen, L. P.H., Pierik, E. G.J.M., Lansink, K. W.W., Bakker, K., Boer, Kimberly R., van Ruler, Oddeke, Reitsma, Johannes B., Mahler, Cecilia W., Opmeer, Brent C., Reuland, E. Ascelijn, Gooszen, Hein G., de Graaf, Peter W., Hesselink, Eric J., Gerhards, Michael F., Steller, E. P.H., Sprangers, Mirjam A., Boermeester, Marja A., De Borgie, Corianne A., Van Till, J. W.O., Bossuyt, P. M.M., Schultz, M. J., Obertop, H., Gouma, D. J., Tanis, P., Hart, H., Guijt, M., Oudemans, H. M., Bosscha, K., Ritchie, E., Vermeer, M., Van Etten, B., Haazer, C., Salm, E., Rommes, H., Oostenbroek, R. J., te Velde, L., Govaert, G., Ponssen, H. H., Dinkelman, M. K., Leenen, L. P.H., Pierik, E. G.J.M., Lansink, K. W.W., and Bakker, K.

Abstract

Background: To compare health related quality of life (HR-QoL) in patients surgically treated for secondary peritonitis to that of a healthy population. And to prospectively identify factors associated with poorer (lower) HR-QoL. Design: A prospective cohort of secondary peritonitis patients was mailed the EQ-5D and EQ-VAS 6-months following initial laparotomy. Setting: Multicenter study in two academic and seven regional teaching hospitals. Patients: 130 of the 155 eligible patients (84%) responded to the HR-QoL questionnaires. Results: HR-QoL was significantly worse on all dimensions in peritonitis patients than in a healthy reference population. Peritonitis characteristics at initial presentation were not associated with HR-QoL at six months. A more complicated course of the disease leading to longer hospitalization times and patients with an enterostomy had a negative impact on the mobility (p = 0.02), self-care (p < 0.001) and daily activities: (p = 0.01). In a multivariate analysis for the EQ-VAS every doubling of hospital stay decreases the EQ-VAS by 3.8 points (p = 0.015). Morbidity during the six-month follow-up was not found to be predictive for the EQ-5D or EQ-VAS. Conclusion: Six months following initial surgery, patients with secondary peritonitis report more problems in HR-QoL than a healthy reference population. Unfavorable disease characteristics at initial presentation were not predictive for poorer HR-QoL, but a more complicated course of the disease was most predictive of HR-QoL at 6 months.

Published
2007

45. Costs of relaparotomy on-demand versus planned relaparotomy in patients with severe peritonitis: an economic evaluation within a randomized controlled trial

Author

Opmeer, Brent C, primary, Boer, Kimberly R, additional, van Ruler, Oddeke, additional, Reitsma, Johannes B, additional, Gooszen, Hein G, additional, de Graaf, Peter W, additional, Lamme, Bas, additional, Gerhards, Michael F, additional, Steller, E Philip, additional, Mahler, Cecilia M, additional, Obertop, Huug, additional, Gouma, Dirk J, additional, Bossuyt, Patrick MM, additional, de Borgie, Corianne AJM, additional, and Boermeester, Marja A, additional

Published
2010
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47. High Diagnostic Yield and Accuracy of History, Physical Examination, and ECG in Patients with Transient Loss of Consciousness in FAST: The Fainting Assessment Study

Author

VAN DIJK, NYNKE, primary, BOER, KIMBERLY R., additional, COLMAN, NANCY, additional, BAKKER, ANNEMIEKE, additional, STAM, JAN, additional, VAN GRIEKEN, JOHANNES J.M., additional, WILDE, ARTHUR A.M., additional, LINZER, MARK, additional, REITSMA, JOHANNES B., additional, and WIELING, WOUTER, additional

Published
2007
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50. Fertility and HIV following universal access to ART in Rwanda: a cross-sectional analysis of Demographic and Health Survey data

Author

Remera, Eric, Boer, Kimberly, Umuhoza, Stella M., Hedt-Gauthier, Bethany L., Thomson, Dana R., Ndimubanzi, Patrick, Kayirangwa, Eugenie, Mutsinzi, Salomon, Bayingana, Alice, Mugwaneza, Placidie, and Koama, Jean Baptiste T.

Subjects
PMTCT, Africa, DHS, Evaluation, Women’s health
Abstract

Background: HIV infection is linked to decreased fertility and fertility desires in sub-Saharan Africa due to biological and social factors. We investigate the relationship between HIV infection and fertility or fertility desires in the context of universal access to antiretroviral therapy introduced in 2004 in Rwanda. Methods: We used data from 3532 and 4527 women aged 20–49 from the 2005 and 2010 Rwandan Demographic and Health Surveys (RDHS), respectively. The RDHSs included blood-tests for HIV, as well as detailed interviews about fertility, demographic and behavioral outcomes. In both years, multiple logistic regression was used to assess the association between HIV and fertility outcomes within three age categories (20–29, 30–39 and 40–49 years), controlling for confounders and compensating for the complex survey design. Results: In 2010, we did not find a difference in the odds of pregnancy in the last 5 years between HIV-seropositive and HIV-seronegative women after controlling for potential biological and social confounders. Controlling for the same confounders, we found that HIV-seropositive women under age 40 were less likely to desire more children compared to HIV-seronegative women (20–29 years adjusted odds ratio (AOR) = 0.31, 95% CI: 0.17, 0.58; 30–39 years AOR = 0.24, 95% CI: 0.14, 0.43), but no difference was found among women aged 40 or older. No associations between HIV and fertility or fertility desire were found in 2005. Conclusions: These findings suggest no difference in births or current pregnancy among HIV-seropositive and HIV-seronegative women. That in 2010 HIV-seropositive women in their earlier childbearing years desired fewer children than HIV-seronegative women could suggest more women with HIV survived; and stigma, fear of transmitting HIV, or realism about living with HIV and prematurely dying from HIV may affect their desire to have children. These findings emphasize the importance of delivering appropriate information about pregnancy and childbearing to HIV-infected women, enabling women living with HIV to make informed decisions about their reproductive life.

Published
2017
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