1. Bioactive alkyl phenols and embelin from Oxalis erythrorhiza.
- Author
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1261551, Rojas de Arias, Gladys Antonieta, Egly Feresin, Gabriela, Tapia, Alejandro, Sortino, Maximiliano, Zacchino, Susana, Inchausti, Alba, Yaluff, Gloria, Rodriguez, Jaime, Theoduloz, Cristina, Schmeda-Hirschmann, Guillermo, 1261551, Rojas de Arias, Gladys Antonieta, Egly Feresin, Gabriela, Tapia, Alejandro, Sortino, Maximiliano, Zacchino, Susana, Inchausti, Alba, Yaluff, Gloria, Rodriguez, Jaime, Theoduloz, Cristina, and Schmeda-Hirschmann, Guillermo
- Abstract
The benzoquinone embelin and four alkyl phenols were isolated from an Argentinean collection of Oxalis erythrorhiza. 3-Heptadecyl-5-methoxy-phenol is reported for the first time. The structures were determined by spectroscopic methods. Embelin presented inhibitory effect on methicillin-resistant Staphylococcus aureus, Escherichia coli and the dermatophytic fungi Epidermophyton floccosum, Microsporum canis, Microsporum gypseum, Trichophyton mentagrophytes and Trichophyton rubrum with MICs ranging between 50 and 100 microg/ml. Furthermore, embelin was active against Trypanosoma cruzi trypomastigotes with 100% lysis at 100 microg/ml and cytotoxicity below the trypanocidal concentration. The new alkyl phenol 3-heptadecyl-5-methoxy-phenol was active towards Leishmania amazonensis and Leishmania donovani promastigotes with 100% lysis at 100 microg/ml. The cytotoxicity (IC50) of embelin and the new alkyl phenol on human lung fibroblasts were 739 and 366 microM, respectively. The plant is used to treat heart complains, a symptomatology related to Chagas' disease which is endemic in the San Juan Province, Argentine.
- Published
- 2019