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1. Development, validation, and prognostic evaluation of a risk score for long-term liver-related outcomes in the general population: a multicohort study

Author

Alvarez, Marifé, Andersen, Peter, Angeli, Paolo, Ardèvol, Alba, Arslanow, Anita, Beggiato, Luca, Ben Abdesselam, Zahia, Bennett, Lucy, Boutouria, Bajiha, Brocca, Alessandra, Broquetas, M. Teresa, Caballeria, Llorenç, Calvino, Valeria, Camacho, Judith, Capdevila, Aura, Carol, Marta, Castera, Laurent, Cervera, Marta, Cucchietti, Fernando, de Fuentes, Anna, de Knegt, Rob, de Koning, Harry J, Detlefsen, Sonke, Diaz, Alba, Diéguez Bande, José, Esnault, Vanessa, Fabrellas, Núria, Falcó, Josep Lluis, Fernández, Rosa, Fournier, Céline, Fuentes, Matilde, Galle, Peter, García, Edgar, García-Retortillo, Montserrat, Garrido, Esther, Ginès, Pere, Gordillo Medina, Rosa, Gratacós-Ginès, Jordi, Graupera, Isabel, Grgurevic, Ivica, Guha, Indra Neil, Guix, Eva, Hansen, Johanne Kragh, Harris, Rebecca, Hernández Boluda, Elena, Hernández-Ibañez, Rosario, Hoyo, Jordi, Ikram, Arfan, Incicco, Simone, Israelsen, Mads, Juan, Marta, Juanola, Adrià, Kaiser, Ralf, Kamath, Patrick S, Karlsen, Tom H, Kjærgaard, Maria, Korenjak, Marko, Krag, Aleksander, Krawczyk, Marcin, Laboulaye, Philippe, Lambert, Irina, Lammert, Frank, Langkjær Sørensen, Simon, Laserna-Jiménez, Cristina, Lazaro Pi, Sonia, Ledain, Elsa, Levy, Vincent, Lindvig, Katrine Prier, Llorca, Anne, Londoño, Vanessa, Loyer, Guirec, Ma, Ann T., Madir, Anita, Manns, Michael, Marshall, Denise, Martí, M. Lluïsa, Martínez, Sara, Martínez Sala, Ricard, Masa-Font, Roser, Møller Jensen, Jane, Morillas, Rosa M, Muñoz, Laura, Nadal, Ruth, Napoleone, Laura, Navarrete, JM, Newsome, Phillip N, Nielsen, Vibeke, Pérez, Martina, Pericás-Pulido, Juan Manuel, Piano, Salvatore, Pich, Judit, Pose, Elisa, Presas Escobet, Judit, Reichert, Matthias, Riba, Carlota, Roulot, Dominique, Rubio, Ana Belén, Sánchez-Morata, Maria, Schattenberg, Jörn, Serra-Burriel, Miquel, Serra-Burriel, Feliu, Skovborg Just, Louise, Sonneveld, Milan, Soria, Anna, Stern, Christiane, Such, Patricia, Thiele, Maja, Tonon, Marta, Toran, Pere, Torrejón, Antoni, Tsochatzis, Emmanuel A, van Kleef, Laurens, van Wijngaarden, Paulien, Velázquez, Vanessa, Viu, Ana, Weber, Susanne Nicole, Wildsmith, Tracey, Pera, Guillem, Reichert, Mathias, Pericàs, Juan M, Schattenberg, Jörn M, Tsochatztis, Emmanuel A, Garcia-Retortillo, Montserrat, Hernández, Rosario, Expósito, Carmen, Martínez, Alba, Detlefsen, Sönke, Martini, Andrea, Ma, Ann T, Pich, Judith, Bonfill, Eva, Navarrete, J M, Hernáez, Rubén, Allen, Alina, de Knegt, Robert J, and Wong, Vincent Wai-Sun

Published
2023
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2. Development, validation, and prognostic evaluation of a risk score for long-term liver-related outcomes in the general population: a multicohort study

Author

Serra-Burriel, Miquel, primary, Juanola, Adrià, additional, Serra-Burriel, Feliu, additional, Thiele, Maja, additional, Graupera, Isabel, additional, Pose, Elisa, additional, Pera, Guillem, additional, Grgurevic, Ivica, additional, Caballeria, Llorenç, additional, Piano, Salvatore, additional, van Kleef, Laurens, additional, Reichert, Mathias, additional, Roulot, Dominique, additional, Pericàs, Juan M, additional, Schattenberg, Jörn M, additional, Tsochatztis, Emmanuel A, additional, Guha, Indra Neil, additional, Garcia-Retortillo, Montserrat, additional, Hernández, Rosario, additional, Hoyo, Jordi, additional, Fuentes, Matilde, additional, Expósito, Carmen, additional, Martínez, Alba, additional, Such, Patricia, additional, Madir, Anita, additional, Detlefsen, Sönke, additional, Tonon, Marta, additional, Martini, Andrea, additional, Ma, Ann T, additional, Pich, Judith, additional, Bonfill, Eva, additional, Juan, Marta, additional, Soria, Anna, additional, Carol, Marta, additional, Gratacós-Ginès, Jordi, additional, Morillas, Rosa M, additional, Toran, Pere, additional, Navarrete, J M, additional, Torrejón, Antoni, additional, Fournier, Céline, additional, Llorca, Anne, additional, Arslanow, Anita, additional, de Koning, Harry J, additional, Cucchietti, Fernando, additional, Manns, Michael, additional, Newsome, Phillip N, additional, Hernáez, Rubén, additional, Allen, Alina, additional, Angeli, Paolo, additional, de Knegt, Robert J, additional, Karlsen, Tom H, additional, Galle, Peter, additional, Wong, Vincent Wai-Sun, additional, Fabrellas, Núria, additional, Castera, Laurent, additional, Krag, Aleksander, additional, Lammert, Frank, additional, Kamath, Patrick S, additional, Ginès, Pere, additional, Alvarez, Marifé, additional, Andersen, Peter, additional, Ardèvol, Alba, additional, Beggiato, Luca, additional, Ben Abdesselam, Zahia, additional, Bennett, Lucy, additional, Boutouria, Bajiha, additional, Brocca, Alessandra, additional, Broquetas, M. Teresa, additional, Calvino, Valeria, additional, Camacho, Judith, additional, Capdevila, Aura, additional, Cervera, Marta, additional, de Fuentes, Anna, additional, de Knegt, Rob, additional, Detlefsen, Sonke, additional, Diaz, Alba, additional, Diéguez Bande, José, additional, Esnault, Vanessa, additional, Falcó, Josep Lluis, additional, Fernández, Rosa, additional, García, Edgar, additional, García-Retortillo, Montserrat, additional, Garrido, Esther, additional, Gordillo Medina, Rosa, additional, Guix, Eva, additional, Hansen, Johanne Kragh, additional, Harris, Rebecca, additional, Hernández Boluda, Elena, additional, Hernández-Ibañez, Rosario, additional, Ikram, Arfan, additional, Incicco, Simone, additional, Israelsen, Mads, additional, Kaiser, Ralf, additional, Kjærgaard, Maria, additional, Korenjak, Marko, additional, Krawczyk, Marcin, additional, Laboulaye, Philippe, additional, Lambert, Irina, additional, Langkjær Sørensen, Simon, additional, Laserna-Jiménez, Cristina, additional, Lazaro Pi, Sonia, additional, Ledain, Elsa, additional, Levy, Vincent, additional, Lindvig, Katrine Prier, additional, Londoño, Vanessa, additional, Loyer, Guirec, additional, Ma, Ann T., additional, Marshall, Denise, additional, Martí, M. Lluïsa, additional, Martínez, Sara, additional, Martínez Sala, Ricard, additional, Masa-Font, Roser, additional, Møller Jensen, Jane, additional, Muñoz, Laura, additional, Nadal, Ruth, additional, Napoleone, Laura, additional, Navarrete, JM, additional, Nielsen, Vibeke, additional, Pérez, Martina, additional, Pericás-Pulido, Juan Manuel, additional, Pich, Judit, additional, Presas Escobet, Judit, additional, Reichert, Matthias, additional, Riba, Carlota, additional, Rubio, Ana Belén, additional, Sánchez-Morata, Maria, additional, Schattenberg, Jörn, additional, Serra-Burriel, Miquel, additional, Skovborg Just, Louise, additional, Sonneveld, Milan, additional, Stern, Christiane, additional, Tsochatzis, Emmanuel A, additional, van Wijngaarden, Paulien, additional, Velázquez, Vanessa, additional, Viu, Ana, additional, Weber, Susanne Nicole, additional, and Wildsmith, Tracey, additional

Published
2023
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3. LiverScreen project: study protocol for screening for liver fibrosis in the general population in European countries

Author

Graupera, Isabel, Thiele, Maja, Ma, Ann T., Serra-Burriel, Miquel, Pich, Judit, Fabrellas, Núria, Caballeria, Llorenç, de Knegt, Robert J., Grgurevic, Ivica, Reichert, Mathias, Roulot, Dominique, Schattenberg, Jörn M., Pericas, Juan M., Angeli, Paolo, Tsochatzis, Emmanuel A., Guha, Indra Neil, Garcia-Retortillo, Montserrat, Morillas, Rosa M., Hernández, Rosario, Hoyo, Jordi, Fuentes, Matilde, Madir, Anita, Juanola, Adrià, Soria, Anna, Juan, Marta, Carol, Marta, Diaz, Alba, Detlefsen, Sönke, Toran, Pere, Fournier, Céline, Llorca, Anne, Newsome, Phillip N., Manns, Michael, de Koning, Harry J., Serra- Burriel, Feliu, Cucchietti, Fernando, Arslanow, Anita, Korenjak, Marko, van Kleef, Laurens, Falcó, Josep Lluis, Kamath, Patrick S., Karlsen, Tom H., Castera, Laurent, Lammert, Frank, Krag, Aleksander, Ginès, Pere, Alvarez, Marifé, Andersen, Peter, Ardèvol, Alba, Beggiato, Luca, Abdesselam, Zahia Ben, Bennett, Lucy, Boutouria, Bajiha, Brocca, Alessandra, Broquetas, M. Teresa, Caballeria, Llorenc, Calvino, Valeria, Camacho, Judith, Capdevila, Aura, Cervera, Marta, de Fuentes, Anna, de Knegt, Rob, Detlefsen, Sonke, Bande, José Diéguez, Esnault, Vanessa, Falco, Josep lluis, Fernández, Rosa, Fournier, Celine, Galle, Peter, García, Edgar, García-Retortillo, Montserrat, Garrido, Esther, Medina, Rosa Gordillo, Gratacós- Gines, Jordi, Guix, Eva, Harris, Rebecca, Boluda, Elena Hernández, Hernández-Ibañez, Rosario, Ikram, Arfan, Incicco, Simone, Israelsen, Mads, Juanola, Adria, Kaiser, Ralf, Kjærgaard, Maria, Hansen, Johanne Kragh, Krawczyk, Marcin, Lambert, Irina, Laboulaye, Philippe, Sørensen, Simon Langkjær, Laserna- Jiménez, Cristina, Pi, Sonia Lazaro, Ledain, Elsa, Levy, Vincent, Londoño, Vanessa, Loyer, Guirec, Marshall, Denise, Martí, M. Lluïsa, Martínez, Sara, Sala, Ricard Martínez, Font, Roser Masa, Jensen, Jane Møller, Muñoz, Laura, Nadal, Ruth, Napoleone, Laura, Navarrete, J. M., Nielsen, Vibeke, Pérez, Martina, Pulido, Juan Manuel Pericas, Piano, Salvatore, Escobet, Judit Presas, Pose, Elisa, Lindvig, Katrine Prier, Reichert, Matthias, Riba, Carlota, Rubio, Ana Belén, Sánchez- Morata, Maria, Schattenberg, Jörn, Just, Louise Skovborg, Sonneveld, Milan, Stern, Christiane, Such, Patricia, Torrejón, Antoni, Tonon, Marta, van Wijngaarden, Paulien, Velázquez, Vanessa, Viu, Ana, Weber, Susanne Nicole, Wildsmith, Tracey, for the LiverScreen Consortium investigators, Gastroenterology & Hepatology, Public Health, and Epidemiology

Subjects
Liver Cirrhosis, Cirrosi hepàtica, Biopsy, Chronic liver disease, Liver fibrosis, Public Health, Environmental and Occupational Health, NASH, Cirrhosis, NAFLD, Screening, Vibration-controlled transient elastography, Europe, Humans, Elasticity Imaging Techniques, Mass Screening, Diagnòstic per la imatge, SDG 3 - Good Health and Well-being, Hepatic cirrhosis, Diagnostic imaging, Biòpsia
Abstract

Background The development of liver cirrhosis is usually an asymptomatic process until late stages when complications occur. The potential reversibility of the disease is dependent on early diagnosis of liver fibrosis and timely targeted treatment. Recently, the use of non-invasive tools has been suggested for screening of liver fibrosis, especially in subjects with risk factors for chronic liver disease. Nevertheless, large population-based studies with cost-effectiveness analyses are still lacking to support the widespread use of such tools. The aim of this study is to investigate whether non-invasive liver stiffness measurement in the general population is useful to identify subjects with asymptomatic, advanced chronic liver disease. Methods This study aims to include 30,000 subjects from eight European countries. Subjects from the general population aged ≥ 40 years without known liver disease will be invited to participate in the study either through phone calls/letters or through their primary care center. In the first study visit, subjects will undergo bloodwork as well as hepatic fat quantification and liver stiffness measurement (LSM) by vibration-controlled transient elastography. If LSM is ≥ 8 kPa and/or if ALT levels are ≥1.5 x upper limit of normal, subjects will be referred to hospital for further evaluation and consideration of liver biopsy. The primary outcome is the percentage of subjects with LSM ≥ 8kPa. In addition, a health economic evaluation will be performed to assess the cost-effectiveness and budget impact of such an intervention. The project is funded by the European Commission H2020 program. Discussion This study comes at an especially important time, as the burden of chronic liver diseases is expected to increase in the coming years. There is consequently an urgent need to change our current approach, from diagnosing the disease late when the impact of interventions may be limited to diagnosing the disease earlier, when the patient is asymptomatic and free of complications, and the disease potentially reversible. Ultimately, the LiverScreen study will serve as a basis from which diagnostic pathways can be developed and adapted to the specific socio-economic and healthcare conditions in each country. Trial registration This study is registered on Clinicaltrials.gov (NCT03789825).

Published
2022

5. Geraniol Pharmacokinetics, Bioavailability and Its Multiple Effects on the Liver Antioxidant and Xenobiotic-Metabolizing Enzymes.

Author

Pavan, Barbara, Dalpiaz, Alessandro, Marani, Luca, Beggiato, Sarah, Ferraro, Luca, Canistro, Donatella, Paolini, Moreno, Vivarelli, Fabio, Valerii, Maria C., Comparone, Antonietta, De Fazio, Luigia, and Spisni, Enzo

Subjects
MONOTERPENES, HEPATOTOXICOLOGY, PHARMACOKINETICS, THERAPEUTICS
Abstract

Geraniol is a natural monoterpene showing anti-inflammatory, antioxidant, neuroprotective and anticancer effects. No pharmacokinetic and bioavailability data on geraniol are currently available. We therefore performed a systematic study to identify the permeation properties of geraniol across intestinal cells, and its pharmacokinetics and bioavailability after intravenous and oral administration to rats. In addition, we systematically investigated the potential hepatotoxic effects of high doses of geraniol on hepatic phase I, phase II and antioxidant enzymatic activities and undertook a hematochemical analysis on mice. Permeation studies performed via HPLC evidenced geraniol permeability coefficients across an in vitro model of the human intestinal wall for apical to basolateral and basolateral to apical transport of 13.10 ± 2.3 × 10-3 and 2.1 ± 0.1⋅× 10-3 cm/min, respectively. After intravenous administration of geraniol to rats (50 mg/kg), its concentration in whole blood (detected via HPLC) decreased following an apparent pseudo-first order kinetics with a half-life of 12.5 ± 1.5 min. The absolute bioavailability values of oral formulations (50 mg/kg) of emulsified geraniol or fiber-adsorbed geraniol were 92 and 16%, respectively. Following emulsified oral administration, geraniol amounts in the cerebrospinal fluid of rats ranged between 0.72 ± 0.08 μg/mL and 2.6 ± 0.2 μg/mL within 60 min. Mice treated with 120 mg/kg of geraniol for 4 weeks showed increased anti-oxidative defenses with no signs of liver toxicity. CYP450 enzyme activities appeared only slightly affected by the high dosage of geraniol. [ABSTRACT FROM AUTHOR]

Published
2018
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6. Serotonin Heteroreceptor Complexes and Their Integration of Signals in Neurons and Astroglia—Relevance for Mental Diseases.

Author

Borroto-Escuela, Dasiel O., Ambrogini, Patrizia, Narvaez, Manuel, Di Liberto, Valentina, Beggiato, Sarah, Ferraro, Luca, Fores-Pons, Ramon, Alvarez-Contino, Jose E., Lopez-Salas, Alexander, Mudò, Giuseppa, Díaz-Cabiale, Zaida, and Fuxe, Kjell

Subjects
RAPHE nuclei, SEROTONIN, ANTIDEPRESSANTS, MENTAL illness, ASTROCYTES, MORPHOLOGY, ANTIPSYCHOTIC agents, NEURAL circuitry
Abstract

The heteroreceptor complexes present a novel biological principle for signal integration. These complexes and their allosteric receptor–receptor interactions are bidirectional and novel targets for treatment of CNS diseases including mental diseases. The existence of D2R-5-HT2AR heterocomplexes can help explain the anti-schizophrenic effects of atypical antipsychotic drugs not only based on blockade of 5-HT2AR and of D2R in higher doses but also based on blocking the allosteric enhancement of D2R protomer signaling by 5-HT2AR protomer activation. This research opens a new understanding of the integration of DA and 5-HT signals released from DA and 5-HT nerve terminal networks. The biological principle of forming 5-HT and other heteroreceptor complexes in the brain also help understand the mechanism of action for especially the 5-HT hallucinogens, including putative positive effects of e.g., psilocybin and the indicated prosocial and anti-stress actions of MDMA (ecstasy). The GalR1-GalR2 heterodimer and the putative GalR1-GalR2-5-HT1 heteroreceptor complexes are targets for Galanin N-terminal fragment Gal (1–15), a major modulator of emotional networks in models of mental disease. GPCR-receptor tyrosine kinase (RTK) heteroreceptor complexes can operate through transactivation of FGFR1 via allosteric mechanisms and indirect interactions over GPCR intracellular pathways involving protein kinase Src which produces tyrosine phosphorylation of the RTK. The exciting discovery was made that several antidepressant drugs such as TCAs and SSRIs as well as the fast-acting antidepressant drug ketamine can directly bind to the TrkB receptor and provide a novel mechanism for their antidepressant actions. Understanding the role of astrocytes and their allosteric receptor–receptor interactions in modulating forebrain glutamate synapses with impact on dorsal raphe-forebrain serotonin neurons is also of high relevance for research on major depressive disorder. [ABSTRACT FROM AUTHOR]

Published
2021
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7. Pandemic Perspectives : Praxis, Policy and Pedagogies

Author

Sandra Joseph, Reena Marwah, Sandra Joseph, and Reena Marwah

Subjects
COVID-19 (Disease)--Social aspects, COVID-19 Pandemic, 2020-
Abstract

The book explores the impacts of the COVID-19 pandemic on nations across the globe since early 2020. It hosts a variety of perspectives within economic, social and development research studies, providing contemporary and proper information. The book also presents policy prescriptions for developing economies, critiques the system of disease surveillance and waste management, and defines a vision for India's development. It also mirrors issues related to digitisation, marginalisation, government regulations and health systems and provides original ideas for innovative methodologies suitable for higher education.Print edition not for sale in South Asia (India, Sri Lanka, Nepal, Bangladesh, Pakistan and Bhutan)

Published
2024

8. Ambulatory Multidisciplinary Management of Postoperative Pain

Author

Jaime Ruiz-Tovar and Jaime Ruiz-Tovar

Subjects
Postoperative pain--Treatment
Abstract

Postoperative pain is a common problem in clinical practice that becomes chronic in approximately 10% to 30% of adults who undergo surgery, being severe in 5 to 10% of them. It is one of the main causes of chronic pain, which makes it a major public health problem. It generates in patients who suffer it a worsening of their quality of life, their psychological well-being, and disability with the consequent incapacity for work. Given that both its etiology and its consequences are complex and multifactorial, postoperative pain must be approached from a multimodal perspective: preventive, pharmacological, nutritional, rehabilitative, nursing intervention, psychological and, in those refractory cases, through surgical approaches or nerve block techniques. This book aims at first to analyze the pathophysiological and psychological bases that underlie its etiology. Next, it aims to carry out an updated review of the multidisciplinary programs for the treatment of postoperative pain that have been carried out and what their results have been. Moreover, the contribution of each of these disciplines in the ambulatory management of postoperative pain will be reviewed. Finally, we want to study the peculiarities of the management of this type of pain in the oncological patient, as well as the personal and socioeconomic consequences and the increase in other comorbidities of this important reason for consultation.

Published
2022

9. Nanni Moretti : L’égarement du présent

Author

Roberto De Gaetano and Roberto De Gaetano

Abstract

Nanni Moretti est l'auteur italien qui, mieux que ses contemporains, a su lire et percevoir les égarements du présent, en représenter les fractures, faire tomber les masques aussi bien privés que publics. De Je suis un autarcique à Mia madre, le cinéma de Moretti a mis en images la radicalité d'une crise existentielle d'un sujet névrotique et fourvoyé, perdu, présent au monde à l'aide de déguisements idiosyncrasiques qui le placent, souvent, sous le signe du grotesque.

Published
2018

10. Recent Studies from University of Foggia Add New Data to Alzheimer Disease (Astrocytic palmitoylethanolamide pre-exposure exerts neuroprotective effects in astrocyte-neuron co-cultures from a triple transgenic mouse model of Alzheimer's disease)

Subjects
Genetic engineering -- Analysis -- Reports -- Models, Physical fitness -- Models -- Reports -- Analysis, Medical research -- Analysis -- Reports -- Models, Advertising executives -- Analysis -- Reports -- Models, Alzheimer's disease -- Analysis -- Reports -- Models, Health
Abstract

2020 JUL 25 (NewsRx) -- By a News Reporter-Staff News Editor at Obesity, Fitness & Wellness Week -- Investigators publish new report on Neurodegenerative Diseases and Conditions - Alzheimer Disease. [...]

Published
2020

11. Reports Outline Immunology Study Results from University of Milan (Kynurenine pathway is altered in BDNF Val66Met knock-in mice: effect of physical exercise)

Subjects
Mental disorders -- Research, Mental health -- Research -- Reports, Health, Psychology and mental health, University of Milan -- Reports
Abstract

2020 AUG 10 (NewsRx) -- By a News Reporter-Staff News Editor at Mental Health Weekly Digest -- Research findings on Immunology are discussed in a new report. According to news [...]

Published
2020

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