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701 results on '"Barone, Giovanni"'

1. Barone, Giovanni

Author

Barone, Giovanni and Barone, Giovanni

Published
2020

36. Exploiting Natural Niches with Neuroprotective Properties: A Comprehensive Review

Author

Moukham, H, Lambiase, A, Barone, G, Tripodi, F, Coccetti, P, Moukham, Hind, Lambiase, Alessia, Barone, Giovanni Davide, Tripodi, Farida, Coccetti, Paola, Moukham, H, Lambiase, A, Barone, G, Tripodi, F, Coccetti, P, Moukham, Hind, Lambiase, Alessia, Barone, Giovanni Davide, Tripodi, Farida, and Coccetti, Paola

Abstract

Natural products from mushrooms, plants, microalgae, and cyanobacteria have been intensively explored and studied for their preventive or therapeutic potential. Among age-related pathologies, neurodegenerative diseases (such as Alzheimer's and Parkinson's diseases) represent a worldwide health and social problem. Since several pathological mechanisms are associated with neurodegeneration, promising strategies against neurodegenerative diseases are aimed to target multiple processes. These approaches usually avoid premature cell death and the loss of function of damaged neurons. This review focuses attention on the preventive and therapeutic potential of several compounds derived from natural sources, which could be exploited for their neuroprotective effect. Curcumin, resveratrol, ergothioneine, and phycocyanin are presented as examples of successful approaches, with a special focus on possible strategies to improve their delivery to the brain.

Published
2024

37. Keratinous and corneous-based products towards circular bioeconomy: A research review

Author

Barone, G, Tagliaro, I, Oliver-Simancas, R, Radice, M, Kalossaka, L, Mattei, M, Biundo, A, Pisano, I, Jiménez-Quero, A, Barone, Giovanni Davide, Tagliaro, Irene, Oliver-Simancas, Rodrigo, Radice, Matteo, Kalossaka, Livia M., Mattei, Michele, Biundo, Antonino, Pisano, Isabella, Jiménez-Quero, Amparo, Barone, G, Tagliaro, I, Oliver-Simancas, R, Radice, M, Kalossaka, L, Mattei, M, Biundo, A, Pisano, I, Jiménez-Quero, A, Barone, Giovanni Davide, Tagliaro, Irene, Oliver-Simancas, Rodrigo, Radice, Matteo, Kalossaka, Livia M., Mattei, Michele, Biundo, Antonino, Pisano, Isabella, and Jiménez-Quero, Amparo

Abstract

Keratins and corneous proteins are key components of biomaterials used in a wide range of applications and are potential substitutes for petrochemical-based products. Horns, hooves, feathers, claws, and similar animal tissues are abundant sources of a- keratin and corneous b- proteins, which are by-products of the food industry. Their close association with the meat industry raises environmental and ethical concerns regarding their disposal. To promote an eco-friendly and circular use of these materials in novel applications, efforts have focused on recovering these residues to develop sustainable, non-animal- related, affordable, and scalable procedures. Here, we review and examine biotechnological methods for extracting and expressing a- keratins and corneous b- proteins in microorganisms. This review highlights consolidated research trends in biomaterials, medical devices, food supplements, and packaging, demonstrating the keratin industry's potential to create innovative value-added products. Additionally, it analyzes the state of the art of related intellectual property and market size to underscore the potential within a circular bioeconomic model. (c) 2024 The Authors. Published by Elsevier B.V. on behalf of Chinese Society for Environmental Sciences, Harbin Institute of Technology, Chinese Research Academy of Environmental Sciences. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

Published
2024

38. Harnessing photosynthetic microorganisms for enhanced bioremediation of microplastics:A comprehensive review

Author

Barone, Giovanni Davide, Rodríguez-Seijo, Andrés, Parati, Mattia, Johnston, Brian, Erdem, Elif, Cernava, Tomislav, Zhu, Zhi, Liu, Xufeng, Axmann, Ilka M., Lindblad, Peter, Radecka, Iza, Barone, Giovanni Davide, Rodríguez-Seijo, Andrés, Parati, Mattia, Johnston, Brian, Erdem, Elif, Cernava, Tomislav, Zhu, Zhi, Liu, Xufeng, Axmann, Ilka M., Lindblad, Peter, and Radecka, Iza

Abstract

Mismanaged plastics, upon entering the environment, undergo degradation through physicochemical and/or biological processes. This process often results in the formation of microplastics (MPs), the most prevalent form of plastic debris (<1 mm). MPs pose severe threats to aquatic and terrestrial ecosystems, necessitating innovative strategies for effective remediation. Some photosynthetic microorganisms can degrade MPs but there lacks a comprehensive review. Here we examine the specific role of photoautotrophic microorganisms in water and soil environments for the biodegradation of plastics, focussing on their unique ability to grow persistently on diverse polymers under sunlight. Notably, these cells utilise light and CO2 to produce valuable compounds such as carbohydrates, lipids, and proteins, showcasing their multifaceted environmental benefits. We address key scientific questions surrounding the utilisation of photosynthetic microorganisms for MPs and nanoplastics (NPs) bioremediation, discussing potential engineering strategies for enhanced efficacy. Our review highlights the significance of alternative biomaterials and the exploration of strains expressing enzymes, such as polyethylene terephthalate (PET) hydrolases, in conjunction with microalgal and/or cyanobacterial metabolisms. Furthermore, we delve into the promising potential of photo-biocatalytic approaches, emphasising the coupling of plastic debris degradation with sunlight exposure. The integration of microalgal-bacterial consortia is explored for biotechnological applications against MPs and NPs pollution, showcasing the synergistic effects in wastewater treatment through the absorption of nitrogen, heavy metals, phosphorous, and carbon. In conclusion, this review provides a comprehensive overview of the current state of research on the use of photoautotrophic cells for plastic bioremediation. It underscores the need for continued investigation into the engineering of these microorga

Published
2024

40. Effect of in-line filtration in newborns: study protocol of the Intravenous Neonatal Central Access Safety (INCAS) randomized controlled trial.

Author

Cresi, Francesco, Maggiora, Elena, Capetti, Cecilia, Capitanio, Martina, Ferroglio, Mattia, Spada, Elena, De Matteis, Francesca, Cosimi, Sara, Mosca, Fabio, Coscia, Alessandra, Aceti, Arianna, Amato, Orsola, Ancora, Gina, Baldassarre, Maria Elisabetta, Barone, Giovanni, Bellan, Cristina, Borgarello, Gabriella, Bottino, Roberto, Campagnoli, Francesca, and Capasso, Antonella

Subjects
NEONATAL intensive care units, INFUSION therapy, NEWBORN infants, PARENTERAL therapy, INCAS, COTTON fibers
Abstract

Background: Particulate contamination due to infusion therapy (administration of parenteral nutrition and medications) carries a potential health risk for infants in neonatal intensive care units (NICUs). This particulate consists of metals, drug crystals, glass fragments, or cotton fibers and can be generated by drug packaging, incomplete reconstitution, and chemical incompatibilities. In-line filters have been shown to remove micro-organisms, endotoxin, air, and particles in critically ill adults and older infants, but its benefits in newborn remain to be demonstrated. Moreover, 50% of inflammatory episodes in the setting of NICUs are blood culture-negative. These episodes could be partly related to the presence of particles in the infusion lines. Methods: A multicenter randomized single-blind controlled trial was designed. All infants admitted to NICUs for which prolonged infusion therapy is expected will be enrolled in the study and randomized to the Filter or Control arm. All patients will be monitored until discharge, and data will be analyzed according to a "full analysis set." The primary outcome is the frequency of patients with at least one sepsis-like event, defined by any association of suspected sepsis symptoms with a level of c-reactive protein (CRP) > 5 mg/L in a negative-culture contest. The frequency of sepsis, phlebitis, luminal obstruction, and the duration of mechanical ventilation and of catheter days will be evaluated as secondary outcomes. The sample size was calculated at 368 patients per arm. Discussion: This is the first multicenter randomized control trial that compares in-line filtration of parenteral nutrition and other intravenous drugs to infusion without filters. Sepsis-like events are commonly diagnosed in clinical practice and are more frequent than sepsis in a positive culture contest. The risk of these episodes in the target population is estimated at 30–35%, but this data is not confirmed in the literature. If the use of in-line filters results in a significant decrease in sepsis-like events and/or in any other complications, the use of in-line filters in all intravenous administration systems may be recommended in NICUs. Trial registration: ClinicalTrials.gov, NCT05537389, registered on 12 September 2022 (https://classic.clinicaltrials.gov/ct2/show/results/NCT05537389?view=results). [ABSTRACT FROM AUTHOR]

Published
2024
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