3,401 results on '"Barbero, R."'
Search Results
2. Maturation of critical technologies for the DEMO balance of plant systems
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Barucca, L., Hering, W., Perez Martin, S., Bubelis, E., Del Nevo, A., Di Prinzio, M., Caramello, M., D'Alessandro, A., Tarallo, A, Vallone, E., Moscato, I., Quartararo, A., D'amico, S, Giannetti, F., Lorusso, P., Narcisi, V., Ciurluini, C., Montes Pita, M.J., Sánchez, C., Rovira, A., Santana, D., Gonzales, P., Barbero, R., Zaupa, M., Szogradi, M., Normann, S., Vaananen, M., Ylatalo, J., Lewandowska, M., Malinowski, L., Martelli, E., Froio, A., Arena, P., and Tincani, A.
- Published
- 2022
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3. Observations of the Hematological, Hematochemical, and Electrophoretic Parameters in Lactating Donkeys (Equus asinus)
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Dezzutto, D, Barbero, R, Valle, E, Giribaldi, M, Raspa, F, Biasato, I, Cavallarin, L, Bergagna, S, McLean, A, and Gennero, MS
- Subjects
Donkey ,Lactation ,Electrophoretic parameter ,Hematology ,Blood chemistry ,Veterinary Sciences - Abstract
A cross-sectional study was conducted on 92 female donkeys. Blood samples were collected, and the following parameters were evaluated: red blood cell (RBC), white blood cell, neutrophil, lymphocyte, monocyte (MON), eosinophil (EOS) and basophil counts, hemoglobin concentration, mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH), mean corpuscular hemoglobin concentration (MCHC), and the hematocrit (HCT), alanine aminotransferase (GPT), aspartate aminotransferase, total proteins, γ-glutamyl-transferase, alkaline phosphatase, creatinine, urea, and blood urea nitrogen and electrophoretic profile. Age (≥2 years ≤ 3 [very young], >3 years ≤ 10 [young], and >10 years ≤ 17 [adult]) and lactation (early lactation [≤3 months], middle [>3 months ≤ 6], and late lactation [>6 months]). Groups were independently analyzed using one-way analysis of variance or Kruskal–Wallis (post hoc test: Bonferroni's or Dunn's multiple test) tests; P was set as
- Published
- 2018
4. Suplementação na época das águas: revisão
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RIBEIRO, A. C. C., primary and BARBERO, R. P., additional
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- 2021
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5. Avaliação visual de bovinos de corte: revisão
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RIBEIRO, A. C. C., primary and BARBERO, R. P., additional
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- 2021
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6. Analysis of the modification of skin and gut microbiota in psoriasis patients treated with phototherapy.
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Navarro-Bielsa A, Gracia-Cazaña T, Del Campo R, Barbero R, López-Gómez C, Gil-Pallares P, and Gilaberte Y
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- Humans, Adult, Male, Female, Middle Aged, Psoriasis therapy, Psoriasis drug therapy, Gastrointestinal Microbiome, Skin microbiology, Phototherapy
- Published
- 2024
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7. Preliminary comparative serological evaluation of Histamine H2 receptors in dogs with an acute onset of vomiting treated with Ranitidine and healthy dogs
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Bottero, E., Benvenuti, E., Ferriani, R., Manassero, E., Re, G., and Barbero, R.
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- 2020
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8. Projections of fire danger under climate change over France: where do the greatest uncertainties lie?
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Fargeon, H., Pimont, F., Martin-StPaul, N., De Caceres, M., Ruffault, J., Barbero, R., and Dupuy, J-L.
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- 2020
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9. Impact of antibiotics, corticosteroids, and microbiota on immunotherapy efficacy in patients with non-small cell lung cancer.
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Zapata-García M, Moratiel-Pellitero A, Isla D, Gálvez E, Gascón-Ruiz M, Sesma A, Barbero R, Galeano J, Del Campo R, Ocáriz M, Quílez E, Cruellas M, Remírez-Labrada A, Pardo J, Martínez-Lostao L, Domingo MP, Esteban P, Torres-Ramón I, Yubero A, Paño JR, and Lastra R
- Abstract
Lung cancer is a leading cause of morbidity and mortality globally, with its high mortality rate attributed mainly to non-small cell lung cancer (NSCLC). Although immunotherapy with immune checkpoint inhibitors (ICI) has revolutionized its treatment, patient response is highly variable and lacking predictive markers. We conducted a prospective study on 55 patients with NSCLC undergoing ICI therapy to identify predictive markers of both response and immune-related adverse events (IrAEs) in the airway microbiota. We also analyzed the clinical evolution and overall survival (OS) with respect to treatments that affect the integrity of the microbiota, such as antibiotics and corticosteroids. Our results demonstrated that respiratory microbiota differ significantly in ICI responders: they have higher alpha diversity values and lower abundance of the Firmicutes phylum and the Streptococcus genus. Employing a logistic regression model, the abundance of Gemella was the major predictor of non-ICI response, whereas Lachnoanaerobaculum was the best predictor of a positive response to ICI. The most relevant results were that antibiotic consumption is linked to a lower ICI response, and the use of corticosteroids correlated with poorer overall survival. Whereas previous studies have focused on gut microbiota, our findings highlight the importance of the respiratory microbiota in predicting the treatment response. Future research should explore microbiota modulation strategies to enhance immunotherapy outcomes. Understanding the impact of antibiotics, corticosteroids, and microbiota on NSCLC immunotherapy will help personalize treatment and improve patient outcomes., Competing Interests: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (© 2024 The Authors.)
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- 2024
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10. Hydrogel particles improve detection of SARS-CoV-2 RNA from multiple sample types
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Barclay, R. A., Akhrymuk, I., Patnaik, A., Callahan, V., Lehman, C., Andersen, P., Barbero, R., Barksdale, S., Dunlap, R., Goldfarb, D., Jones-Roe, T., Kelly, R., Kim, B., Miao, S., Munns, A., Munns, D., Patel, S., Porter, E., Ramsey, R., Sahoo, S., Swahn, O., Warsh, J., Kehn-Hall, K., and Lepene, B.
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- 2020
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11. Super-Clausius–Clapeyron Scaling of Extreme Hourly Convective Precipitation and Its Relation to Large-Scale Atmospheric Conditions
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Lenderink, G., Barbero, R., Loriaux, J. M., and Fowler, H. J.
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- 2017
12. P257 Microbiological characterisation of methicillin-resistant Staphylococcus aureus isolates recovered from cystic fibrosis people during two Spanish multicentre studies (2013–2021)
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Maruri-Aransolo, A., primary, Barbero, R., additional, Del Campo, R., additional, Pastor, M.D., additional, Mondejar-Lopez, P., additional, Solé, A., additional, Selma, M.J., additional, Cantón, R., additional, and Caballero-Pérez, J.D.D., additional
- Published
- 2023
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13. Resistome, Virulome, and Clonal Variation in Methicillin-Resistant Staphylococcus aureus (MRSA) in Healthy Swine Populations: A Cross-Sectional Study.
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Silva V, Silva A, Barbero R, Romero M, Del Campo R, Caniça M, Cordeiro R, Igrejas G, and Poeta P
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- Animals, Swine, Cross-Sectional Studies, Microbial Sensitivity Tests, Portugal epidemiology, Whole Genome Sequencing, Virulence Factors genetics, Prevalence, Drug Resistance, Multiple, Bacterial genetics, Methicillin-Resistant Staphylococcus aureus genetics, Methicillin-Resistant Staphylococcus aureus drug effects, Methicillin-Resistant Staphylococcus aureus pathogenicity, Staphylococcal Infections veterinary, Staphylococcal Infections microbiology, Staphylococcal Infections epidemiology, Staphylococcal Infections drug therapy, Swine Diseases microbiology, Swine Diseases epidemiology, Anti-Bacterial Agents pharmacology
- Abstract
This cross-sectional study investigates the methicillin-resistant Staphylococcus aureus (MRSA): its prevalence, antimicrobial resistance, and molecular characteristics in healthy swine populations in central Portugal. A total of 213 samples were collected from pigs on twelve farms, and MRSA prevalence was assessed using selective agar plates and confirmed via molecular methods. Antimicrobial susceptibility testing and whole genome sequencing (WGS) were performed to characterize resistance profiles and genetic determinants. Among the 107 MRSA-positive samples (83.1% prevalence), fattening pigs and breeding sows exhibited notably high carriage rates. The genome of 20 isolates revealed the predominance of the ST398 clonal complex, with diverse spa types identified. Antimicrobial susceptibility testing demonstrated resistance to multiple antimicrobial agents, including penicillin, cefoxitin, and tetracycline. WGS analysis identified a diverse array of resistance genes, highlighting the genetic basis of antimicrobial resistance. Moreover, virulence gene profiling revealed the presence of genes associated with pathogenicity. These findings underscore the significant prevalence of MRSA in swine populations and emphasize the need for enhanced surveillance and control measures to mitigate zoonotic transmission risks. Implementation of prudent antimicrobial use practices and targeted intervention strategies is essential to reducing MRSA prevalence and safeguarding public health. Continued research efforts are warranted to elucidate transmission dynamics and virulence potential, ultimately ensuring food safety and public health protection.
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- 2024
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14. Reply to: Satellite artifacts modulate FireCCILT11 global burned area.
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Cardil A, Rodrigues M, Barbero R, Ramírez J, Stoof C, Silva CA, Mohan M, Gelabert P, Ortega M, and de-Miguel S
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- 2024
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15. In vitro and ex vivo pharmacodynamics of selected non-steroidal anti-inflammatory drugs in equine whole blood
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Cuniberti, B., Odore, R., Barbero, R., Cagnardi, P., Badino, P., Girardi, C., and Re, G.
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- 2012
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16. Utilizing benthic foraminifera to explore the environmental condition of the Laizhou Bay (Bohai Sea, China)
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Donnici S.[1], Serandrei-Barbero R.[2], Gao X.[3, 4, Tang C.[3, and Tosi L.[1]
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0106 biological sciences ,Biotope ,China ,Geologic Sediments ,Foraminifera ,010501 environmental sciences ,Aquatic Science ,Oceanography ,01 natural sciences ,0105 earth and related environmental sciences ,Biotic index ,geography ,geography.geographical_feature_category ,River delta ,biology ,010604 marine biology & hydrobiology ,benthic foraminifera ,Foram-AMBI ,foraminiferal biotopes ,Laizhou Bay ,Estuary ,biology.organism_classification ,Pollution ,Bays ,Habitat ,Benthic zone ,Environmental science ,Bay ,Water Pollutants, Chemical ,Environmental Monitoring - Abstract
Through the analysis of benthic foraminifera in the soft bottom sediments of the Laizhou Bay – Yellow River Delta system, this study characterized the foraminiferal biotopes and explored the possibility of obtaining an index of ecological quality comparable with other estuarine and coastal environments of the world. Five foraminiferal biotopes have been identified and their distribution patterns highlight the ecological stress from the marine-fluvial water mixing and pollution. The foraminiferal species were analyzed as a function of organic carbon gradients, and the main species were assigned to four ecological groups based on their sensitivity/tolerance towards an increasing stress gradient. Finally, the relative proportions of the species assigned to the four different ecological groups were used for the definition of a marine biotic index based on foraminifera, i.e. the Foram-AMBI, and thus the assessment of the ecological quality status of marine soft-bottom habitats.
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- 2021
17. Nanotrap Particles Improve Nanopore Sequencing of SARS-CoV-2 and Other Respiratory Viruses
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Andersen, P, primary, Barksdale, S, additional, Barclay, RA, additional, Smith, N, additional, Fernandes, J, additional, Besse, K, additional, Goldfarb, D, additional, Barbero, R, additional, Dunlap, R, additional, Jones-Roe, T, additional, Kelly, R, additional, Miao, S, additional, Ruhunusiri, C, additional, Munns, A, additional, Mosavi, S, additional, Sanson, L, additional, Munns, D, additional, Sahoo, S, additional, Swahn, O, additional, Hull, K, additional, White, D, additional, Kolb, K, additional, Noroozi, F, additional, Seelam, J, additional, Patnaik, A, additional, and Lepene, B, additional
- Published
- 2021
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18. Comparison of Nanotrap ® Microbiome A Particles, membrane filtration, and skim milk workflows for SARS-CoV-2 concentration in wastewater.
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Liu P, Guo L, Cavallo M, Cantrell C, Hilton SP, Nguyen A, Long A, Dunbar J, Barbero R, Barclay R, Sablon O 3rd, Wolfe M, Lepene B, and Moe C
- Abstract
Introduction: Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) RNA monitoring in wastewater has become an important tool for Coronavirus Disease 2019 (COVID-19) surveillance. Grab (quantitative) and passive samples (qualitative) are two distinct wastewater sampling methods. Although many viral concentration methods such as the usage of membrane filtration and skim milk are reported, these methods generally require large volumes of wastewater, expensive lab equipment, and laborious processes., Methods: The objectives of this study were to compare two workflows (Nanotrap
® Microbiome A Particles coupled with MagMax kit and membrane filtration workflows coupled with RNeasy kit) for SARS-CoV-2 recovery in grab samples and two workflows (Nanotrap® Microbiome A Particles and skim milk workflows coupled with MagMax kit) for SARS-CoV-2 recovery in Moore swab samples. The Nanotrap particle workflow was initially evaluated with and without the addition of the enhancement reagent 1 (ER1) in 10 mL wastewater. RT-qPCR targeting the nucleocapsid protein was used for detecting SARS-CoV-2 RNA., Results: Adding ER1 to wastewater prior to viral concentration significantly improved viral concentration results ( P < 0.0001) in 10 mL grab and swab samples processed by automated or manual Nanotrap workflows. SARS-CoV-2 concentrations in 10 mL grab and Moore swab samples with ER1 processed by the automated workflow as a whole showed significantly higher ( P < 0.001) results than 150 mL grab samples using the membrane filtration workflow and 250 mL swab samples using the skim milk workflow, respectively. Spiking known genome copies (GC) of inactivated SARS-CoV-2 into 10 mL wastewater indicated that the limit of detection of the automated Nanotrap workflow was ~11.5 GC/mL using the RT-qPCR and 115 GC/mL using the digital PCR methods., Discussion: These results suggest that Nanotrap workflows could substitute the traditional membrane filtration and skim milk workflows for viral concentration without compromising the assay sensitivity. The manual workflow can be used in resource-limited areas, and the automated workflow is appropriate for large-scale COVID-19 wastewater-based surveillance., Competing Interests: RBarb, BL, RBarc, and CC were employed by Ceres Nanosciences, Inc. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2023 Liu, Guo, Cavallo, Cantrell, Hilton, Nguyen, Long, Dunbar, Barbero, Barclay, Sablon, Wolfe, Lepene and Moe.)- Published
- 2023
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19. Prediction of regional wildfire activity in the probabilistic Bayesian framework of Firelihood.
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Pimont F, Fargeon H, Opitz T, Ruffault J, Barbero R, Martin-StPaul N, Rigolot E, RiviÉre M, and Dupuy JL
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- Bayes Theorem, Ecosystem, Forests, Fires, Wildfires
- Abstract
Modeling wildfire activity is crucial for informing science-based risk management and understanding the spatiotemporal dynamics of fire-prone ecosystems worldwide. Models help disentangle the relative influences of different factors, understand wildfire predictability, and provide insights into specific events. Here, we develop Firelihood, a two-component, Bayesian, hierarchically structured, probabilistic model of daily fire activity, which is modeled as the outcome of a marked point process: individual fires are the points (occurrence component), and fire sizes are the marks (size component). The space-time Poisson model for occurrence is adjusted to gridded fire counts using the integrated nested Laplace approximation (INLA) combined with the stochastic partial differential equation (SPDE) approach. The size model is based on piecewise-estimated Pareto and generalized Pareto distributions, adjusted with INLA. The Fire Weather Index (FWI) and forest area are the main explanatory variables. Temporal and spatial residuals are included to improve the consistency of the relationship between weather and fire occurrence. The posterior distribution of the Bayesian model provided 1,000 replications of fire activity that were compared with observations at various temporal and spatial scales in Mediterranean France. The number of fires larger than 1 ha across the region was coarsely reproduced at the daily scale, and was more accurately predicted on a weekly basis or longer. The regional weekly total number of larger fires (10-100 ha) was predicted as well, but the accuracy degraded with size, as the model uncertainty increased with event rareness. Local predictions of fire numbers or burned areas also required a longer aggregation period to maintain model accuracy. The estimation of fires larger than 1 ha was also consistent with observations during the extreme fire season of the 2003 unprecedented heat wave, but the model systematically underrepresented large fires and burned areas, which suggests that the FWI does not consistently rate the actual danger of large fire occurrence during heat waves. Firelihood enabled a novel analysis of the stochasticity underlying fire hazard, and offers a variety of applications, including fire hazard predictions for management and projections in the context of climate change., (© 2021 by the Ecological Society of America.)
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- 2021
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20. Botulinum toxin type A as an adjunct in postoperative pain management in dogs undergoing radical mastectomy
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Vilhegas, S., Cassu, R. N., Barbero, R. C., Crociolli, G. C., Rocha, T. L. A., and Gomes, D. R.
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- 2015
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21. Effects of flunixin meglumine and ketoprofen on mediator production in ex vivo and in vitro models of inflammation in healthy dairy cows
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DONALISIO, C., BARBERO, R., CUNIBERTI, B., VERCELLI, C., CASALONE, M., and RE, G.
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- 2013
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22. A PK/PD study in trachemis turtles after single intracoelomic injection of Marbofloxacin at different doses: 9.3.
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VERCELLI, C., GIORGI, M., DE VITO, V., SALVADORI, M., BARBERO, R., DEZZUTTO, D., BERGAGNA, S., GENNERO, M. S., and RE, G.
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- 2015
23. Expression and functionality of TRPV1 receptor in human MCF-7 and canine CF.41 cells
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Vercelli, C., Barbero, R., Cuniberti, B., Odore, R., and Re, G.
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- 2015
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24. Anthropogenic intensification of short-duration rainfall extremes
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Fowler, HJ, Lenderink, G, Prein, AF, Westra, S, Allan, RP, Ban, N, Barbero, R, Berg, P, Blenkinsop, S, Do, HX, Guerreiro, S, Haerter, JO, Kendon, EJ, Lewis, E, Schaer, C, Sharma, A, Villarini, G, Wasko, C, Zhang, X, Fowler, HJ, Lenderink, G, Prein, AF, Westra, S, Allan, RP, Ban, N, Barbero, R, Berg, P, Blenkinsop, S, Do, HX, Guerreiro, S, Haerter, JO, Kendon, EJ, Lewis, E, Schaer, C, Sharma, A, Villarini, G, Wasko, C, and Zhang, X
- Published
- 2021
25. Towards advancing scientific knowledge of climate change impacts on short-duration rainfall extremes
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Fowler, HJ, Ali, H, Allan, RP, Ban, N, Barbero, R, Berg, P, Blenkinsop, S, Cabi, NS, Chan, S, Dale, M, Dunn, RJH, Ekstrom, M, Evans, JP, Fosser, G, Golding, B, Guerreiro, SB, Hegerl, GC, Kahraman, A, Kendon, EJ, Lenderink, G, Lewis, E, Li, X, O'Gorman, PA, Orr, HG, Peat, KL, Prein, AF, Pritchard, D, Schar, C, Sharma, A, Stott, PA, Villalobos-Herrera, R, Villarini, G, Wasko, C, Wehner, MF, Westra, S, Whitford, A, Fowler, HJ, Ali, H, Allan, RP, Ban, N, Barbero, R, Berg, P, Blenkinsop, S, Cabi, NS, Chan, S, Dale, M, Dunn, RJH, Ekstrom, M, Evans, JP, Fosser, G, Golding, B, Guerreiro, SB, Hegerl, GC, Kahraman, A, Kendon, EJ, Lenderink, G, Lewis, E, Li, X, O'Gorman, PA, Orr, HG, Peat, KL, Prein, AF, Pritchard, D, Schar, C, Sharma, A, Stott, PA, Villalobos-Herrera, R, Villarini, G, Wasko, C, Wehner, MF, Westra, S, and Whitford, A
- Abstract
A large number of recent studies have aimed at understanding short-duration rainfall extremes, due to their impacts on flash floods, landslides and debris flows and potential for these to worsen with global warming. This has been led in a concerted international effort by the INTENSE Crosscutting Project of the GEWEX (Global Energy and Water Exchanges) Hydroclimatology Panel. Here, we summarize the main findings so far and suggest future directions for research, including: the benefits of convection-permitting climate modelling; towards understanding mechanisms of change; the usefulness of temperature-scaling relations; towards detecting and attributing extreme rainfall change; and the need for international coordination and collaboration. Evidence suggests that the intensity of long-duration (1 day+) heavy precipitation increases with climate warming close to the Clausius-Clapeyron (CC) rate (6-7% K-1), although large-scale circulation changes affect this response regionally. However, rare events can scale at higher rates, and localized heavy short-duration (hourly and sub-hourly) intensities can respond more strongly (e.g. 2 × CC instead of CC). Day-to-day scaling of short-duration intensities supports a higher scaling, with mechanisms proposed for this related to local-scale dynamics of convective storms, but its relevance to climate change is not clear. Uncertainty in changes to precipitation extremes remains and is influenced by many factors, including large-scale circulation, convective storm dynamics andstratification. Despite this, recent research has increased confidence in both the detectability and understanding of changes in various aspects of intense short-duration rainfall. To make further progress, the international coordination of datasets, model experiments and evaluations will be required, with consistent and standardized comparison methods and metrics, and recommendations are made for these frameworks. This article is part of a discussion meeting
- Published
- 2021
26. Scientific Reports
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Barclay, R. A., Akhrymuk, Ivan V., Patnaik, A., Callahan, Victoria, Lehman, C., Andersen, P., Barbero, R., Barksdale, S., Dunlap, R., Goldfarb, D., Jones-Roe, T., Kelly, R., Kim, B., Miao, S., Munns, A., Munns, D., Patel, S., Porter, E., Ramsey, R., Sahoo, S., Swahn, O., Warsh, J., Kehn-Hall, Kylene, Lepene, Benjamin, and Biomedical Sciences and Pathobiology
- Subjects
Diagnostic Tests, Routine ,SARS-CoV-2 ,viruses ,COVID-19 ,Hydrogels ,Viral Load ,Real-Time Polymerase Chain Reaction ,Sensitivity and Specificity ,Specimen Handling ,COVID-19 Testing ,Nasopharynx ,Humans ,RNA, Viral ,Saliva - Abstract
Here we present a rapid and versatile method for capturing and concentrating SARS-CoV-2 from contrived transport medium and saliva samples using affinity-capture magnetic hydrogel particles. We demonstrate that the method concentrates virus from 1 mL samples prior to RNA extraction, substantially improving detection of virus using real-time RT-PCR across a range of viral titers (100–1,000,000 viral copies/mL) and enabling detection of virus using the 2019 nCoV CDC EUA Kit down to 100 viral copies/mL. This method is compatible with commercially available nucleic acid extraction kits (i.e., from Qiagen) and a simple heat and detergent method that extracts viral RNA directly off the particle, allowing a sample processing time of 10 min. We furthermore tested our method in transport medium diagnostic remnant samples that previously had been tested for SARS-CoV-2, showing that our method not only correctly identified all positive samples but also substantially improved detection of the virus in low viral load samples. The average improvement in cycle threshold value across all viral titers tested was 3.1. Finally, we illustrate that our method could potentially be used to enable pooled testing, as we observed considerable improvement in the detection of SARS-CoV-2 RNA from sample volumes of up to 10 mL. Published version
- Published
- 2020
27. In vitro enantioselective pharmacodynamics of Carprofen and Flunixin-meglumine in feedlot cattle
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Miciletta, M., Cuniberti, B., Barbero, R., and Re, G.
- Published
- 2014
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28. Atypical processing in neural source analysis of speech envelope modulations in adolescents with dyslexia.
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Granados Barbero R, de Vos A, Ghesquière P, and Wouters J
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- Acoustic Stimulation, Adolescent, Brain, Humans, Speech, Auditory Cortex, Dyslexia, Speech Perception
- Abstract
Different studies have suggested that language and developmental disorders such as dyslexia are associated with a disturbance of auditory entrainment and of the functional hemispheric asymmetries during speech processing. These disorders typically result from an issue in the phonological component of language that causes problems to represent and manipulate the phonological structure of words at the syllable and/or phoneme level. We used Auditory Steady-State Responses (ASSRs) in EEG recordings to investigate the brain activation and hemisphere asymmetry of theta, alpha, beta and low-gamma range oscillations in typical readers and readers with dyslexia. The aim was to analyse whether the group differences found in previous electrode level studies were caused by a different source activation pattern or conversely was an effect that could be found on the active brain sources. We could not find differences in the brain locations of the main active brain sources. However, we observed differences in the extracted waveforms. The group average of the first DSS component of all signal-to-noise ratios of ASSR at source level was higher than the group averages at the electrode level. These analyses included a lower alpha synchronisation in adolescents with dyslexia and the possibility of compensatory mechanisms in theta, beta and low-gamma frequency bands. The main brain auditory sources were located in cortical regions around the auditory cortex. Thus, the differences observed in auditory EEG experiments would, according to our findings, have their origin in the intrinsic oscillatory mechanisms of the brain cortical sources related to speech perception., (© 2021 Federation of European Neuroscience Societies and John Wiley & Sons Ltd.)
- Published
- 2021
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29. A CFD comparative study of bubble break-up models in a turbulent multiphase jet
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Martín-Valdepeñas, J. M., Jiménez, M. A., Barbero, R., and Martín-Fuertes, F.
- Published
- 2007
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30. Increased likelihood of heat-induced large wildfires in the Mediterranean Basin
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Ruffault, J, Curt, T, Moron, V, Trigo, RM, Mouillot, F, Koutsias, N, Pimont, F, Martin-StPaul, NK, Barbero, R, Dupuy, J-L, Russo, A, Belhadj-Kheder, C, Institut méditerranéen de biodiversité et d'écologie marine et continentale (IMBE), Avignon Université (AU)-Aix Marseille Université (AMU)-Institut de recherche pour le développement [IRD] : UMR237-Centre National de la Recherche Scientifique (CNRS), Aix Marseille Université (AMU), Risques, Ecosystèmes, Vulnérabilité, Environnement, Résilience (RECOVER), Aix Marseille Université (AMU)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Centre européen de recherche et d'enseignement des géosciences de l'environnement (CEREGE), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Collège de France (CdF (institution))-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Universidade de Lisboa = University of Lisbon (ULISBOA), Centre d’Ecologie Fonctionnelle et Evolutive (CEFE), Université Paul-Valéry - Montpellier 3 (UPVM)-École Pratique des Hautes Études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD [France-Sud])-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Institut Agro - Montpellier SupAgro, Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro), University of Patras, Ecologie des Forêts Méditerranéennes (URFM), Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Université de la Manouba [Tunisie] (UMA), FCT (Fundação para a Ciência e a Tecnologia, Portugal) under project IMPECAF (PTDC/CTA-CLI/28902/2017), ANR-11-IDEX-0001,Amidex,INITIATIVE D'EXCELLENCE AIX MARSEILLE UNIVERSITE(2011), Aix Marseille Université (AMU)-Institut national des sciences de l'Univers (INSU - CNRS)-Collège de France (CdF (institution))-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD), Universidade de Lisboa (ULISBOA), Université Paul-Valéry - Montpellier 3 (UPVM)-Centre international d'études supérieures en sciences agronomiques (Montpellier SupAgro)-École pratique des hautes études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD [France-Sud])-Institut national d’études supérieures agronomiques de Montpellier (Montpellier SupAgro), Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), and University of Patras [Patras]
- Subjects
Heat induced ,Ecology ,010504 meteorology & atmospheric sciences ,Fire ecology ,[SDE.MCG]Environmental Sciences/Global Changes ,lcsh:R ,Natural hazards ,lcsh:Medicine ,Climate change ,15. Life on land ,010501 environmental sciences ,Future climate ,01 natural sciences ,Mediterranean Basin ,Article ,Fire weather ,13. Climate action ,Climatology ,Environmental science ,lcsh:Q ,lcsh:Science ,Climate-change impacts ,0105 earth and related environmental sciences - Abstract
International audience; Wildfire activity is expected to increase across the Mediterranean Basin because of climate change. However, the effects of future climate change on the combinations of atmospheric conditions that promote wildfire activity remain largely unknown. Using a fire-weather based classification of wildfires, we show that future climate scenarios point to an increase in the frequency of two heat-induced fire-weather types that have been related to the largest wildfires in recent years. Heat-induced fire-weather types are characterized by compound dry and warm conditions occurring during summer heatwaves, either under moderate (heatwave type) or intense (hot drought type) drought. The frequency of heat-induced fire-weather is projected to increase by 14% by the end of the century (2071-2100) under the RCP4.5 scenario, and by 30% under the RCP8.5, suggesting that the frequency and extent of large wildfires will increase throughout the Mediterranean Basin. Wildfire is a complex phenomenon that occurs when three conditions are met: available fuel, an ignition source (due to lightning or human activities) and weather conditions conducive to fires (fire weather) 1. Climate and weather are important drivers of wildfire activity across a range of timescales 2-5 , and, consequently, current and potential future climate-induced changes in wildfire activity might threaten ecosystems and human well-being 6. In most Euro-Mediterranean countries, wildfire activity has been declining owing to management and suppression measures undertaken since the 1980s 7. However, some recent extreme wildfire events, including those that occurred in 2016 in France 8 , 2017 in Spain and Portugal 9 and 2018 in Greece 10 have highlighted the limits of wildfire suppression capabilities under exceptional fire-weather conditions. Furthermore, studies show that wildfire activity is expected to increase across the Mediterranean Basin due to climate change 11,12. However, how the combinations of climate and weather conditions that promote the largest wildfires will respond to climate change remain largely unknown. Climate and weather are both drivers of wildfire activity. Soil moisture deficit over days to months increases fuel aridity and flammability 6,13 while a number of synoptic weather conditions associated to different combinations of short-term and instantaneous meteorological fields (precipitation, temperature, relative humidity and wind speed) influence wildfire behaviour 5,14. Most of the largest wildfires occur when these conditions are met 8. For instance, the combination of extreme drought with extreme wind or heatwaves have both been identified as crucial factors in the occurrence of crown wildfires in Mediterranean forests and shrublands 15-17. In this study, we focus on the frequency of current and future weather and climate conditions associated with wildfires in four countries (France, Portugal, Greece, Tunisia) of the Mediterranean basin covering most of its diverse biogeographic and climatic conditions (Supplementary Figs. S1-S3). Building on the insights gained open
- Published
- 2020
31. Climate teleconnections modulate global burned area.
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Cardil A, Rodrigues M, Tapia M, Barbero R, Ramírez J, Stoof CR, Silva CA, Mohan M, and de-Miguel S
- Subjects
- Ecosystem, Weather, Biomass, Climate Change, Climate, Fires
- Abstract
Climate teleconnections (CT) remotely influence weather conditions in many regions on Earth, entailing changes in primary drivers of fire activity such as vegetation biomass accumulation and moisture. We reveal significant relationships between the main global CTs and burned area that vary across and within continents and biomes according to both synchronous and lagged signals, and marked regional patterns. Overall, CTs modulate 52.9% of global burned area, the Tropical North Atlantic mode being the most relevant CT. Here, we summarized the CT-fire relationships into a set of six global CT domains that are discussed by continent, considering the underlying mechanisms relating weather patterns and vegetation types with burned area across the different world's biomes. Our findings highlight the regional CT-fire relationships worldwide, aiming to further support fire management and policy-making., (© 2023. The Author(s).)
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- 2023
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32. Identification of the VR-1 Vanilloid Receptor in Cell Cultures
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Barbero, R., Badino, P., Cuniberti, B., Miolo, A., Odore, R., Girardi, C., and Re, G.
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- 2006
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33. Impact of atmospheric circulation on the rainfall-temperature relationship in Australia
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Magan, B, Kim, S, Wasko, C, Barbero, R, Moron, V, Nathan, R, Sharma, A, Magan, B, Kim, S, Wasko, C, Barbero, R, Moron, V, Nathan, R, and Sharma, A
- Abstract
Anthropogenic climate change is leading to the intensification of extreme rainfall due to an increase in atmospheric water holding capacity at higher temperatures as governed by the Clausius-Clapeyron (C-C) relationship. However, the rainfall-temperature sensitivity (termed scaling) often deviates from the C-C relationship. This manuscript uses classifications prescribed by regional-scale atmospheric circulation patterns to investigate whether deviations from the C-C relationship in tropical Australia can be explained by differing weather types (WT). We show that the rainfall-temperature scaling differs depending on the WTs, with the difference increasing with rainfall magnitude. All monsoonal WTs have similar scaling, in excess of the C-C relationship, while trade winds (the driest WTs) result in the greatest scaling, up to twice that of the C-C relationship. Finally, we show the scaling for each WT also varies spatially, illustrating that both local factors and the WT will contribute to the behaviour of rainfall under warming.
- Published
- 2020
34. Hydrogel particles improve detection of SARS-CoV-2 RNA from multiple sample types
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Biomedical Sciences and Pathobiology, Barclay, R. A., Akhrymuk, Ivan V., Patnaik, A., Callahan, Victoria, Lehman, C., Andersen, P., Barbero, R., Barksdale, S., Dunlap, R., Goldfarb, D., Jones-Roe, T., Kelly, R., Kim, B., Miao, S., Munns, A., Munns, D., Patel, S., Porter, E., Ramsey, R., Sahoo, S., Swahn, O., Warsh, J., Kehn-Hall, Kylene, Lepene, Benjamin, Biomedical Sciences and Pathobiology, Barclay, R. A., Akhrymuk, Ivan V., Patnaik, A., Callahan, Victoria, Lehman, C., Andersen, P., Barbero, R., Barksdale, S., Dunlap, R., Goldfarb, D., Jones-Roe, T., Kelly, R., Kim, B., Miao, S., Munns, A., Munns, D., Patel, S., Porter, E., Ramsey, R., Sahoo, S., Swahn, O., Warsh, J., Kehn-Hall, Kylene, and Lepene, Benjamin
- Abstract
Here we present a rapid and versatile method for capturing and concentrating SARS-CoV-2 from contrived transport medium and saliva samples using affinity-capture magnetic hydrogel particles. We demonstrate that the method concentrates virus from 1 mL samples prior to RNA extraction, substantially improving detection of virus using real-time RT-PCR across a range of viral titers (100–1,000,000 viral copies/mL) and enabling detection of virus using the 2019 nCoV CDC EUA Kit down to 100 viral copies/mL. This method is compatible with commercially available nucleic acid extraction kits (i.e., from Qiagen) and a simple heat and detergent method that extracts viral RNA directly off the particle, allowing a sample processing time of 10 min. We furthermore tested our method in transport medium diagnostic remnant samples that previously had been tested for SARS-CoV-2, showing that our method not only correctly identified all positive samples but also substantially improved detection of the virus in low viral load samples. The average improvement in cycle threshold value across all viral titers tested was 3.1. Finally, we illustrate that our method could potentially be used to enable pooled testing, as we observed considerable improvement in the detection of SARS-CoV-2 RNA from sample volumes of up to 10 mL.
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- 2020
35. Analysis of source term aspects in the experiment Phebus FPT1 with the MELCOR and CFX codes
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Martín-Fuertes, F., Barbero, R., Martín-Valdepeñas, J.M., and Jiménez, M.A.
- Published
- 2007
- Full Text
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36. Improved Detection of Herpesviruses from Diluted Vitreous Specimens Using Hydrogel Particles.
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Belanger NL, Barbero R, Barclay R, Lepene B, Sobrin L, and Bispo PJM
- Abstract
Infectious uveitis is a sight-threatening infection commonly caused by herpesviruses. Vitreous humor is often collected for molecular confirmation of the causative agent during vitrectomy and mixed in large volumes of buffered saline, diluting the pathogen load. Here, we explore affinity-capture hydrogel particles (Nanotrap
® ) to concentrate low abundant herpesviruses from diluted vitreous. Simulated samples were prepared using porcine vitreous spiked with HSV-1, HSV-2, VZV and CMV at 105 copies/mL. Pure undiluted samples were used to test capturing capability of three custom Nanotrap particles (red, white and blue) in a vitreous matrix. We found that all particles demonstrated affinity to the herpesviruses, with the Red Particles having both good capture capability and ease of handling for all herpesviruses. To mimic diluted vitrectomy specimens, simulated-infected vitreous were then serially diluted in 7 mL TE buffer. Diluted samples were subjected to an enrichment protocol using the Nanotrap Red particles. Sensitivity of pathogen detection by qPCR in diluted vitreous increased anywhere between 2.3 to 26.5 times compared to non-enriched specimens. This resulted in a 10-fold increase in the limit of detection for HSV-1, HSV-2 and VZV. These data demonstrated that Nanotrap particles can capture and concentrate HSV-1, HSV-2, VZV and CMV in a vitreous matrix.- Published
- 2022
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37. Expression and functionality of TRPV1 receptor in human and canine mammary cancer cells: evaluation of the role of vanilloid system: 6.3.
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VERCELLI, C., BARBERO, R., CUNIBERTI, B., and RE, G.
- Published
- 2012
38. Nanotrap® particles improve detection of SARS-CoV-2 for pooled sample methods, extraction-free saliva methods, and extraction-free transport medium methods
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Barclay, RA, primary, Akhrymuk, I, additional, Patnaik, A, additional, Callahan, V, additional, Lehman, C, additional, Andersen, P, additional, Barbero, R, additional, Barksdale, S, additional, Dunlap, R, additional, Goldfarb, D, additional, Jones-Roe, T, additional, Kelly, R, additional, Kim, B, additional, Miao, S, additional, Munns, A, additional, Munns, D, additional, Patel, S, additional, Porter, E, additional, Ramsey, R, additional, Sahoo, S, additional, Swahn, O, additional, Warsh, J, additional, Kehn-Hall, K, additional, and Lepene, B, additional
- Published
- 2020
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39. Prediction of regional wildfire activity with a probabilistic Bayesian framework
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Pimont, F, primary, Fargeon, H, additional, Opitz, T, additional, Ruffault, J, additional, Barbero, R, additional, Martin StPaul, N, additional, Rigolot, E, additional, Rivière, M, additional, and Dupuy, JL, additional
- Published
- 2020
- Full Text
- View/download PDF
40. Increased likelihood of heat-induced large wildfires in the Mediterranean Basin
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Ruffault, J, primary, Curt, T, additional, Moron, V, additional, Trigo, RM, additional, Mouillot, F, additional, Koutsias, N, additional, Pimont, F, additional, Martin-StPaul, NK, additional, Barbero, R, additional, Dupuy, J-L, additional, Russo, A, additional, and Belhadj-Kheder, C, additional
- Published
- 2020
- Full Text
- View/download PDF
41. How do animal performance and methane emissions vary with forage management intensification and supplementation?
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Koscheck, J. F. W., primary, Romanzini, E. P., additional, Barbero, R. P., additional, Delevatti, L. M., additional, Ferrari, A. C., additional, Mulliniks, J. T., additional, Mousquer, C. J., additional, Berchielli, T. T., additional, and Reis, R. A., additional
- Published
- 2020
- Full Text
- View/download PDF
42. Does large fire activity vary within the French Mediterranean area?
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Ganteaume, A., Barbero, R., Risques, Ecosystèmes, Vulnérabilité, Environnement, Résilience (RECOVER), Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA)-Aix Marseille Université (AMU), and Aix Marseille Université (AMU)-Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA)
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[SDE]Environmental Sciences ,LARGE FIRE RECURRENCE ,BURNED AREA ,LARGE FIRE OCCURRENCE ,FIRE CAUSES - Abstract
[Departement_IRSTEA]Territoires [TR1_IRSTEA]SEDYVIN [ADD1_IRSTEA]Adaptation des territoires au changement global; International audience; In the French Mediterranean, large fires have significant socio-economic and environmental impacts. The previous works dealing with fires in the French Mediterranean were based on gridded fire data commencing from the mid-1970s (e.g., Ruffault et al., 2016; Fréjaville and Curt, 2017; Ganteaume and Guerra, 2018; Lahaye et al., 2018). Working with longer time-series of georeferenced fires (extending back to 1958) would allow examining both spatial and temporal distributions of large fires (>100 ha) across the French Mediterranean. The objectives of this work were (i) to identify the locations associated with large fire recurrence and to quantify the spatial extent of the region with reburns, (ii) to establish the mean fire extent and the fire return level as well as the LF causes along a longitudinal transect spanning the study area (identifying possible roles of climate conditions and fuel continuity in shaping this longitudinal gradient), and (iii), building on previous research, to re-estimate trends in large fires across the region taking advantage of a fire record spanning almost six decades. A long-term geo-referenced fire time series (1958-2017) was used to analyse both spatial and temporal distributions of large fires (LF; ≥100 ha). Large fire causes were analysed according to the regional fire database Promethée that has recorded fires since 1973. The region was impacted in some locations up to 6 times by recurrent LF (Fig. 1) and 21% of the total area burned by LF occurred on a surface that previously burned in the past, with potential impact on forest resilience. We found contrasting patterns between the East and the West of the study area, the former experiencing fewer LF but of a larger extent compared to the latter, with an average time of occurrence between LF exceeding 4,000 ha 50 years in the West. This longitudinal gradient in LF return level contrasts with what we would expect from mean fire weather conditions strongly decreasing eastwards during the fire season but is consistent with larger fuel cover in the East, highlighting the strong role of fuel continuity in fire spread (Fig. 2). Figure 1: Fire recurrence on the 1961-2017 and 1958-2016 period in the western and eastern areas, respectively. Figure 2: Top) Longitudinal cross-section of mean LF extent computed over 30-km sliding windows. The 95% confidence intervals were estimated using a bootstrapping approach. Bottom) Same as top panel but for mean June-September FWI (in red) and the percent of biomass (in green). Additionally, our analysis confirms the sharp decrease in both LF frequency and burned area in the early 1990s, due to the efficiency of fire suppression and prevention reinforced at that time, thereby weakening the functional climate-fire relationship across the region. Regarding the causes of LF, the proportion of unknown cause was high throughout the region, varying from 74% to 77% from the West to the East. It is worth noting that the knowledge of smaller fires
- Published
- 2019
43. Simulating the effects of weather and climate on large wildfires in France
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Barbero, R., Curt, T., Ganteaume, A., Maille, E., Jappiot, M., Bellet, Adeline, Risques, Ecosystèmes, Vulnérabilité, Environnement, Résilience (RECOVER), and Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA)-Aix Marseille Université (AMU)
- Subjects
[SDE]Environmental Sciences - Abstract
International audience; Large wildfires across parts of France can cause devastating damage which puts lives, infrastructure, and the natural ecosystem at risk. In the climate change context, it is essential to better understand how these large wildfires relate to weather and climate and how they might change in a warmer world. Such projections rely on the development of a robust modelling framework linking large wildfires to present-day atmospheric variability. Drawing from a MODIS product and a gridded meteorological dataset, we derived a suite of biophysical and fire danger indices and developed generalized linear models simulating the probability of large wildfires ( > 100 ha) at 8 km spatial and daily temporal resolutions across the entire country over the last two decades. The models were able to reproduce large-wildfire activity across a range of spatial and temporal scales. Different sensitivities to weather and climate were detected across different environmental regions. Long-term drought was found to be a significant predictor of large wildfires in flammability-limited systems such as the Alpine and south-western regions. In the Mediterranean, large wildfires were found to be associated with both short-term fire weather conditions and longer-term soil moisture deficits, collectively facilitating the occurrence of large wildfires. Simulated probabilities on days with large wildfires were on average 2-3 times higher than normal with respect to the mean seasonal cycle, highlighting the key role of atmospheric variability in wildfire spread. The model has wide applications, including improving our understanding of the drivers of large wildfires over the historical period and providing a basis on which to estimate future changes to large wildfires from climate scenarios.
- Published
- 2019
44. Effects of Inflammation upon β-adrenoceptor Concentrations in the Common Digital Artery of the Horse: An in vitro Study
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Barbero, R., Badino, P., Cuniberti, B., Magistris, G., Odore, R., Pagliasso, S., Girardi, C., and Re, G.
- Published
- 2005
- Full Text
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45. Development of Atypical Reading at Ages 5 to 9 Years and Processing of Speech Envelope Modulations in the Brain.
- Author
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Granados Barbero R, Ghesquière P, and Wouters J
- Abstract
Different studies have suggested that during speech processing readers with dyslexia present atypical levels of neural entrainment as well as atypical functional hemispherical asymmetries in comparison with typical readers. In this study, we evaluated these differences in children and the variation with age before and after starting with formal reading instruction. Synchronized neural auditory processing activity was quantified based on auditory steady-state responses (ASSRs) from EEG recordings. The stimulation was modulated at syllabic and phonemic fluctuation rates present in speech. We measured the brain activation patterns and the hemispherical asymmetries in children at three age points (5, 7, and 9 years old). Despite the well-known heterogeneity during developmental stages, especially in children and in dyslexia, we could extract meaningful common oscillatory patterns. The analyses included (1) the estimations of source localization, (2) hemispherical preferences using a laterality index, measures of neural entrainment, (3) signal-to-noise ratios (SNRs), and (4) connectivity using phase coherence measures. In this longitudinal study, we confirmed that the existence of atypical levels of neural entrainment and connectivity already exists at pre-reading stages. Overall, these measures reflected a lower ability of the dyslectic brain to synchronize with syllabic rate stimulation. In addition, our findings reinforced the hypothesis of a later maturation of the processing of beta rhythms in dyslexia. This investigation emphasizes the importance of longitudinal studies in dyslexia, especially in children, where neural oscillatory patterns as well as differences between typical and atypical developing children can vary in the span of a year., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2022 Granados Barbero, Ghesquière and Wouters.)
- Published
- 2022
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46. The environment of Venice area in the past two million years
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Massari, F, Rio, D, Serandrei Barbero, R, Asioli, A, Capraro, L, Fornaciari, E, and Vergerio, P.P
- Published
- 2004
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47. Ancient and modern salt marshes in the Lagoon of Venice
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Serandrei Barbero, R., Albani, A.D., and Bonardi, M.
- Published
- 2004
- Full Text
- View/download PDF
48. Impact of Disaster Research on the Development of Early Career Researchers: Lessons Learned from the Wastewater Monitoring Pandemic Response Efforts.
- Author
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Delgado Vela J, McClary-Gutierrez JS, Al-Faliti M, Allan V, Arts P, Barbero R, Bell C, D'Souza N, Bakker K, Kaya D, Gonzalez R, Harrison K, Kannoly S, Keenum I, Li L, Pecson B, Philo SE, Schneider R, Schussman MK, Shrestha A, Stadler LB, Wigginton KR, Boehm A, Halden RU, and Bibby K
- Subjects
- Wastewater, Disasters, Pandemics
- Published
- 2022
- Full Text
- View/download PDF
49. Modulation of Antioxidant Defense in Farmed Rainbow Trout ( Oncorhynchus mykiss ) Fed with a Diet Supplemented by the Waste Derived from the Supercritical Fluid Extraction of Basil ( Ocimum basilicum ).
- Author
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Magara G, Prearo M, Vercelli C, Barbero R, Micera M, Botto A, Caimi C, Caldaroni B, Bertea CM, Mannino G, Barceló D, Renzi M, Gasco L, Re G, Dondo A, Elia AC, and Pastorino P
- Abstract
Phytotherapy is based on the use of plants to prevent or treat human and animal diseases. Recently, the use of essential oils and polyphenol-enriched extracts is also rapidly increasing in the aquaculture sector as a means of greater industrial and environmental sustainability. Previous studies assessed the antibacterial and antiparasitic effects of these bioactive compounds on fish. However, studies on the modulation of oxidative stress biomarkers are still scant to date. Thus, in this study, the modulation of antioxidant defense against oxidative stress exerted by fish diets supplemented with a basil supercritical extract (F1-BEO) was assessed in rainbow trout Oncorhynchus mykiss . The F1-BEO extracted with supercritical fluid extraction was added to the commercial feed flour (0.5, 1, 2, 3% w / w ) and mixed with fish oil to obtain a suitable compound for pellet preparation. Fish were fed for 30 days. The levels of stress biomarkers such as superoxide dismutase, catalase, glutathione peroxidase, glutathione S-transferase, glutathione reductase, glyoxalase I, glyoxalase II, lactate dehydrogenase, glutathione and malondialdehyde showed a boost in the antioxidant pathway in fish fed with a 0.5% F1-BEO-supplemented diet. Higher F1-BEO supplementation led to a failure of activity of several enzymes and the depletion of glutathione levels. Malondialdehyde concentration suggests a sufficient oxidative stress defense against lipid peroxidation in all experimental groups, except for a 3% F1-BEO-supplemented diet (liver 168.87 ± 38.79 nmol/mg prot; kidney 146.86 ± 23.28 nmol/mg prot), compared to control (liver 127.76 ± 18.15 nmol/mg prot; kidney 98.68 ± 15.65 nmol/mg prot). Our results suggest supplementing F1-BEO in fish diets up to 0.5% to avoid potential oxidative pressure in farmed trout.
- Published
- 2022
- Full Text
- View/download PDF
50. The INTENSE project: using observations and models to understand the past, present and future of sub-daily rainfall extremes
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Blenkinsop, S., Fowler, H.J., Barbero, R., Chan, S.C., Guerreiro, S.B., Kendon, E., Lenderink, G., Lewis, E., Li, X.F., Westra, S., Alexander, L., Allan, R.P., Berg, Peer, Dunn, R.J.H., Ekström, M., Evans, J.P., Holland, G., Jones, R., Kjellström, E., Klein-Tank, A., Lettenmaier, D., Mishra, V., Prein, A.F., Sheffield, J., Tye, M.R., SCHOOL OF ENGINEERING UNIVERSITY OF NEWCASTLE NEWCASTLE UPON TYNE GBR, Partenaires IRSTEA, Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA)-Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA), Risques, Ecosystèmes, Vulnérabilité, Environnement, Résilience (RECOVER), Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA)-Aix Marseille Université (AMU), MET OFFICE HADLEY CENTRE EXETER GBR, KNMI ROYAL NETHERLANDS METEOROLOGICAL INSTITUTE DE BILT NLD, SCHOOL OF CIVIL ENVIRONMENTAL AND MINING ENGINEERING UNIVERSITY OF ADELAIDE AUS, CLIMATE CHANGE RESEARCH CENTRE UNIVERSITY OF NEW SOUTH WALES SYDNEY AUS, UNIVERSITY OF READING GBR, and SMHI NORRK
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[SDE]Environmental Sciences - Abstract
National audience; Historical in situ sub-daily rainfall observations are essential for the understanding of short-duration rainfall extremes but records are typically not readily accessible and data are often subject to errors and inhomogeneities. Furthermore, these events are poorly quantified in projections of future climate change making adaptation to the risk of flash flooding problematic. Consequently, knowledge of the processes contributing to intense, short-duration rainfall is less complete compared with those on daily timescales. The INTENSE project is addressing this global challenge by undertaking a data collection initiative that is coupled with advances in high-resolution climate modelling to better understand key processes and likely future change. The project has so far acquired data from over 23 000 rain gauges for its global sub-daily rainfall dataset (GSDR) and has provided evidence of an intensification of hourly extremes over the US. Studies of these observations, combined with model simulations, will continue to advance our understanding of the role of local-scale thermodynamics and large-scale atmospheric circulation in the generation of these events and how these might change in the future.
- Published
- 2018
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