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This study presents a comprehensive approach to vibrational analysis in a size-dependent, orthotropic thermo-piezo-photo-electric semiconductor half-space under Moore–Gibson–Thompson (MGT) photo-thermoelasticity theory with memory-dependent derivatives. Following Eringen's nonlocal elasticity theory, the governing equations for the considered material are derived. The normal mode technique is applied to investigate the photothermal excitation process. Focusing on the interface adjacent to the vacuum, the study considers plasma, thermal, and mechanical stress boundary conditions to determine fundamental physical quantities. Through a detailed exploration, this research examines the impact of various thermo-piezo-photo-electric models, time, nonlocal parameters, and spatial coordinates on different physical quantities. The effects are meticulously analyzed and visually represented through graphical illustrations. While the literature survey reveals numerous studies on vibrational analysis in thermo-piezo-photo-electric semiconductor mediums under different thermoelasticity theories, to the best of the authors' knowledge, no research emphasizing vibrational analysis in a size-dependent thermo-piezo-photo-electric semiconductor medium has been conducted. Moreover, the effect of memory-dependent MGT photo-thermoelasticity theory on a size-dependent thermo-piezo-photo-electric semiconductor half-space has not been illuminated until now, significantly defining the novelty of the conducted research. [ABSTRACT FROM AUTHOR]

This manuscript examines the effects of memory-dependent and fractional-order derivatives on a novel generalized piezo-thermo-elastic semiconductor model. The medium is homogenous and orthotropic, subjected to photo-thermal excitation. The governing equations include fractional-order parameters, relaxation time, time delay, and kernel function tailored to specific problem requirements. Normal mode method use to solve the equations, yielding analytical expressions. Graphical representations show physical field distribution across various fractional-order parameters, kernel functions, time delay, and frequency values. This study has the potential to advance precise model development and future simulations. [ABSTRACT FROM AUTHOR]

This study uses the triple-phase lag model to investigate how higher-order fractional order and memory-dependent derivatives affect reflection at the free surface of an orthotropic piezo-thermoelastic medium. The performance of both kinds of derivatives is studied using the normal mode analysis technique. Four different types of coupled reflected plane waves are identified and explore the impact of various parameters, fractional order parameter, kernel function, the higher-order time differential fractional, and memory-dependent heat conduction parameters on energy distribution with respect to the angle of incidence. The results are presented graphically, providing numerical data for reflected waves, amplitude, and energy ratios. [ABSTRACT FROM AUTHOR]

In the context of the triple-phase lag model, comparison studies are conducted between the memory-dependent derivative and fractional order derivative on the propagation of plane waves in a half-space of initially stressed transversely isotropic piezothermoelastic material. The coupled governing equations of the considered model involving relaxation time, time delay, fractional order parameter, and kernel function are selected according to specific problems and solved using the normal mode analysis technique and obtaining the analytical expression. The non-dimensional temperature, displacement, electrical displacements, and stresses at different values of the fractional order parameter and time delay factor are obtained graphically. [ABSTRACT FROM AUTHOR]

Venetoclax (Ven) plus hypomethylating agents are considered standard-of-care for patients with acute myeloid leukemia (AML) judged ineligible for intensive chemotherapy (IC). Real-world studies complement clinical trials, since patterns of patient selection, treatment-exposure and post-remission management may vary. This prospective observational multi-center study included 209 newly diagnosed IC-ineligible patients with a median age 75 years (interquartile range, 71-81 years). A high proportion of patients had secondary AML (53.7%), adverse-risk disease (35.3%), and complex karyotype (15.5%). At a median follow-up of 22.5 months (range 0.1-43), median overall-survival (mOS) was 11.7 months (95% Confidence Interval [CI] 9.9,15.4). Composite complete remission (CRc) was achieved in 65.2% (CR 44.4%; CRi 20.8%). Of responding patients, 21.1% underwent stem-cell transplantation. When stratified based on VIALE-A original eligibility criteria, mOS was 17.8 months for patients meeting eligibility criteria and 10.7 months for patients who did not (p=0.027). AML ontogeny (p=0.024), reduced kidney function (p=0.001), Charlson co-morbidity index (CCI; p=0.0017), ELN-risk (p=0.01) and body-mass index (p=0.0298) were significantly associated with OS. Multivariant Cox-regression analysis confirmed independent association of OS with AML ontogeny (p=0.012), CCI (p=0.033) and ELN-risk (p=0.019). Patients enrolled in the latter half of the study period demonstrated improved OS compared to those enrolled earlier (p=0.026). This prospective observational study highlights outcomes of patient subgroups, including those excluded from registration trials. (clinicaltrials.gov: #NCT03987958)., (Copyright © 2024 American Society of Hematology.)

Medical devices that contact non-intact skin or mucous membranes are considered semi-critical devices and must undergo high-level disinfection (HLD) before use. Studies have identified several potential limitations of UV-C for HLD of semi-critical medical devices, including a lack of data demonstrating that UV-C irradiance can be uniformly applied to complex surfaces that contain grooves, notches and imperfections. This study focused on ultrasound probes as commonly used medical devices to show the distribution of irradiance on these surfaces. An endocavity bi-plane probe and curved array surface probe with typical surface topology were 3D scanned and modelled and an array of UV-C light-emitting diodes (LEDs) irradiating the probe surfaces was simulated (simulated wavelength: 275nm [peak], power output: 50mW). The simulated chamber wall material was equivalent to highly reflective polished aluminum with a defined reflectance of 79% at 275nm. To calculate the cycle time required to achieve HLD on probe surfaces, a minimum effective dosage of 1500mJ/cm2 based on published research was used. The simulated irradiance distribution showed a large difference between the points of highest and lowest irradiance (maximum/minimum ratio: 14.70 for the surface probe and 12.74 for the endocavity probe). In addition, the presence of shadowing effects adjacent to notches or grooves was evident. By applying an effective UV-C dose from the literature, cycle times of up to 25 minutes would be required to achieve HLD in the minimally irradiated areas of the probes used in the simulation. These findings highlight the need to demonstrate the efficacy of UV-C radiation against worst case organisms in the areas of lowest irradiance on medical devices to provide assurance these devices are reliably high level disinfected., Competing Interests: LY, LC, MB, LYT, GS and JB are employees of Nanosonics Ltd. LYT, GS and JB hold stock in Nanosonics Ltd. All authors are employed by a commercial company: Nanosonics Ltd. This does not alter our adherence to PLOS ONE policies on sharing data and materials., (Copyright: © 2024 Yeoh et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.)

We tested composite tracheal grafts (CTG) composed of a partially decellularized tracheal graft (PDTG) combined with a 3-dimensional (3D)-printed airway splint for use in long-segment airway reconstruction. CTG is designed to recapitulate the 3D extracellular matrix of the trachea with stable mechanical properties imparted from the extraluminal airway splint. We performed segmental orthotopic tracheal replacement in a mouse microsurgical model. MicroCT was used to measure graft patency. Tracheal neotissue formation was quantified histologically. Airflow dynamic properties were analyzed using computational fluid dynamics. We found that CTG are easily implanted and did not result in vascular erosion, tracheal injury, or inflammation. Graft epithelialization and endothelialization were comparable with CTG to control. Tracheal collapse was absent with CTG. Composite tracheal scaffolds combine biocompatible synthetic support with PDTG, supporting the regeneration of host epithelium while maintaining graft structure.

This study introduces a two-dimensional thermoelastic model for a homogeneous isotropic half-space with double porosity underlying an inviscid liquid half-space featuring temperature variations. The model incorporates the three-phase lag (TPL) heat equation and reveals that in the solid half-space, four coupled longitudinal waves intertwine with one uncoupled transverse wave, while one mechanical wave ripples through the liquid half-space. The investigation highlights dispersion, attenuation, and other effects affected by the thermal properties and the presence of voids. Using plane wave solutions and boundary conditions at the interface, a concise expression for the frequency equation of the model has been derived. Furthermore, the magnitudes of the displacements in the solid half-space and liquid half-spaces, the temperature change, and the volume fractional fields at the interface have been precisely determined. In the graphical section, computer-simulated results of various wave profiles for magnesium crystal material have been generated for different heat conduction thermoelastic models. The study's implications span various fields, such as hydrology, engineering, ultrasonics, navigation, and electronics. [ABSTRACT FROM AUTHOR]

Decellularized tracheal scaffolds offer a potential solution for the repair of long-segment tracheal defects. However, complete decellularization of trachea is complicated by tracheal collapse. We created a partially decellularized tracheal scaffold (DTS) and characterized regeneration in a mouse model of tracheal transplantation. All cell populations except chondrocytes were eliminated from DTS. DTS maintained graft integrity as well as its predominant extracellular matrix (ECM) proteins. We then assessed the performance of DTS in vivo. Grafts formed a functional epithelium by study endpoint (28 days). While initial chondrocyte viability was low, this was found to improve in vivo . We then used atomic force microscopy to quantify micromechanical properties of DTS, demonstrating that orthotopic implantation and graft regeneration lead to the restoration of native tracheal rigidity. We conclude that DTS preserves the cartilage ECM, supports neo-epithelialization, endothelialization and chondrocyte viability, and can serve as a potential solution for long-segment tracheal defects.

Sickle cell disease (SCD) is the most common genetic blood disorder in the United States, with over 100,000 people suffering from this debilitating disease. SCD is caused by abnormal hemoglobin (Hb) variants that interfere with normal red blood cell (RBC) function. Research on SCD has led to the development and approval of several new SCD therapies in recent years. The recent FDA-approved novel gene therapies are potentially curative, giving patients an additional option besides a hematopoietic bone marrow transplant. Despite the promise of existing therapies, questions remain regarding their long-term pharmacological effects on adults and children. These questions, along with the exorbitant cost of the new gene therapies, justify additional research into more effective therapeutic options. Continual research in this field focuses on not only developing cheaper, more effective cures/treatments but also investigating the physiological effects of the current therapies on SCD patients, particularly on the brain and kidneys. In this article, we undertake a comprehensive review of ongoing clinical trials with completion dates in 2024 or later. Our exploration provides insights into the landscape of current therapeutics and emerging novel therapies designed to combat and potentially eradicate SCD, including the latest FDA-approved gene therapies.

In this narrative, a general practitioner and psychotherapist trained in anthroposophic medicine presents the narrative and treatment of a 60-year-old woman who experienced the horrors of the "Dark Sabbath" attack in southern Israel on October 7, 2023. The patient's story is narrated by the physician, who shares his multi-disciplinary and multi-modal anthroposophic medicine approach to address the patient's acute stress disorder-related symptoms and concerns., (© 2024. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)

Objective: Vaccination against preventable infections is important for the management of rheumatic diseases (RDs). This study assessed the vaccination coverage and predictors among patients with RDs using real-world data from Israel., Methods: This retrospective cross-sectional study, based on a Maccabi Healthcare Services database, included adult patients diagnosed with rheumatoid arthritis (RA), psoriatic arthritis (PsA), and systemic lupus erythematosus (SLE), as of April 30, 2019. Age-specific vaccination coverage for influenza (past year), pneumococcal (23-valent pneumococcal polysaccharide vaccine [PPSV23] and/or 13-valent pneumococcal conjugate vaccine [PCV13]), and live-attenuated herpes zoster (HZ) vaccines (past 5 years) was reported. Logistic regression was used to investigate predictors of vaccination., Results: The study included 14,528 patients (RA: n = 6932; PsA: n = 4395; SLE: n = 1951; > 1 condition: n = 1250). Influenza vaccine coverage among patients with RA, PsA, and SLE was 45.1%, 36.2%, and 33.7%, respectively. For PPSV23, corresponding rates were 19.6%, 16.2%, and 12.6%, respectively. In the elderly population (≥ 65 years), 63.2% had influenza vaccine in the past year and 83.4% had a PPSV23 vaccine in the past 5 years or at age ≥ 65. For PCV13 and HZ, coverage in the overall study population was low at 4.8% and 3.6%, respectively. Central residence and treatment with corticosteroids and biologic or targeted synthetic disease-modifying antirheumatic drugs within the past 5 years were significant predictors of vaccination coverage across all vaccines ( P < 0.05). Other predictors varied by vaccine, including female sex (influenza, PPSV23, PCV13), age (influenza, PPSV23), chronic comorbidities (influenza, PPSV23, PCV13), shorter disease duration (PCV13), and high socioeconomic status (PCV13, HZ)., Conclusion: This study demonstrated suboptimal coverage of influenza, pneumococcal, and HZ vaccination in patients with RA, PsA, and SLE, in particular among younger adults in Israel., (Copyright © 2024 by the Journal of Rheumatology.)

This research article presents an analysis of the behavior of an initially stressed monoclinic piezothermoelastic half-space based on memory-dependent three-phase lags heat transfer law (MPS) underlying a thermoelastic half-space (TS) with subject to the hyperbolic two-temperature (H2T), classical two-temperature (C2T), and without two-temperature (W2T) models. By applying the normal mode approach, calculate the amplitude ratios and further utilize them to obtain the waves' energy ratios and interaction energy. The effect of memory-dependent derivatives (MDD), initial stresses, various kernel functions, and two temperature factors on the variation of energy ratios with incidence angle are graphically shown. The findings of this study have the potential to optimize material design, enhance seismic imaging techniques, improve thermal management in machinery, develop renewable energy systems, and facilitate materials characterization across diverse industries. [ABSTRACT FROM AUTHOR]