1,213 results on '"B. Ungar"'
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2. Steven B. Ungar reappointed to Oregon State Lottery Commission
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Regulatory compliance ,Gambling industry ,Business ,Business, regional ,News, opinion and commentary - Abstract
Gov. Ted Kulongoski has reappointed Steven B. Ungar to the Oregon State Lottery Commission. Ungar is a Lane Powell shareholder and chair of LP's white collar criminal defense and regulatory [...]
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- 2008
3. Alan B. Ungar
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Business ,Business, regional - Abstract
Thousand Oaks resident and Calabasas businessman Alan B. Ungar will be honored as the Valley Industry and Commerce Association's 2003 recipient of the 'Harmon Ballin Award for Community Service.' The [...]
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- 2003
4. P806 Perianal Crohn’s Disease (pCD): The outcome of 2nd line and 3rd line biologics in perianal Crohn’s disease
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U Shani, N Ben Shabat, E Klang, B Ungar, S Ben-Horin, and U Kopylov
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Gastroenterology ,General Medicine - Abstract
Background Treating perianal Crohn’s disease (pCD) is challenging with at least 60% of the patients not responding or relapsing after a year of 1st line biological therapy. Effectiveness data on 2nd and 3rd line in pCD is still quite limited. The aim of this study was to describe the effectiveness of 2nd and 3rd line biological therapy in pCD. Methods A retrospective cohort study of patients with pCD from a large tertiary center registry. We included all patients with pCD that were treated with >1 biologic while anti-TNF was the first one used. Primary outcome was defined as clinical failure of 2nd or 3rd line treatment (as defined by the clinician) or radiological evidence for disease progression by MRI or transrectal ultrasonography (TRUS). Secondary outcomes were relapse of perianal fistula or abscess. Results Registry included 893 patients with pCD who are being followed up routinely in a dedicated IBD clinic; 643 patients received 1 biological were excluded. Final cohort included 245 patients treated with ≥2 biologics. In 2nd line, 40/245 patients (16%) treated with infliximab (IFX), 128/245 (52%) with adalimumab (ADA), 48/245 (20%) with vedolizumab (VDZ) and 32/245 (13%) with ustekinumab (UST). 7/32 patients (22%) treated with UST failed the treatment, compared to 32/40 (80%), 101/128 (79%) , 37/48 (77%) patients treated with IFX, ADA and VDZ, respectively [Hazard Ratio(HR) 0.27 (0.1-0.69)]. Median time of 2nd line treatment with UST, anti-TNFs and VDZb was 2.5 (IQR=1-3[uk1] ), 3 (IQR=1-5) and 3 (IQR=1-4) years, respectively. Higher response rate in 2nd line therapy was associated with longer response duration to 1st line [OR (1.11-1.55), p 99/245 patients (40%) required 3rd line treatment (VDZ - 52/99 , UST - 47/99 (48%)) patients). 8/47 patients (17%) under UST therapy experienced clinical failure, compared to 41/52 (78.8%) patients treated with VDZ [HR 0.32 (0.12-0.68)]. Median duration (years) of third line treatment with both UST and VDZ was 3 years (IQR=3-1). Figure A shows Kaplan-Meier survival analysis to 2nd line and 3rd line failure. Conclusion 2nd and 3rd line biological therapies may be efficacious in pCD patients. Ustekinumab appears to be effective as a 2nd or 3rd line treatment. Longer duration of treatment is associated with a higher likelihood of response to 2nd line treatment.
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- 2023
5. P560 Curcumin-QingDai combination for patients with active ulcerative colitis: A randomized double-blinded placebo-controlled trial
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S Ben-Horin, N Salomon, G Karampekos, N Viazis, A Lahat, B Ungar, R Eliakim, O Kriger-Sharabi, H Reiss-Mintz, H Yanai, I Dotan, E Zittan, N Maharshak, A Hirsch, M Weitman, G J Mantzaris, and U Kopylov
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Gastroenterology ,General Medicine - Abstract
Background The herbal extracts Curcumin and QingDai (QD, Indigo) were previously shown to be effective in mild-moderate and in moderate-severe ulcerative colitis (UC), respectively. We evaluated the efficacy and safety of a combination of curcumin-QingDai (CurQD) in patients with active UC. Methods This was a two parts trial. Part 1 was an open label study of 4 weeks CurQD in patients with active UC, defined by a Simple Clinical Colitis Activity Index (SCCAI) score ≥5 and a modified Mayo endoscopic sub-score≥2. Part 2 was a placebo-controlled trial conducted in two centers in Israel and Greece, that randomized active UC patients at a 2:1 ratio to either enteric-coated CurQD 3gr/day or an identical placebo for eight weeks. The co-primary outcome at week 8 was clinical response (reduction in SCCAI of ≥3 points) and an objective evidence of response (Mayo endoscopic subscore improvement of ≥1 or 50% calprotectin reduction from baseline). Responding patients continued either curcumin or placebo alone for additional 8 weeks as maintenance treatment. Expression of Cyp1A1 in rectal mucosa was assessed as a measure of aryl-hydrocarbon receptor (AhR) pathway activation. Curcumin purity, and indigo and indirubin content in CurQD were confirmed by LC-MS/MS. Results There were 59 patients enrolled in the two study parts. In efficacy analysis of part 1, 7/10 responded including 3/10 who achieved clinical remission. For part 2, 95 patients were screened and 42 were included and randomized (48.8% biologics and/or immuno-modulators experienced, 36.6% biologics-experienced). The co-primary outcome was achieved in 43% and 8% of CurQD and placebo patients, respectively (p=0.033). Clinical response was observed in 85.7% versus 30.7% (p Conclusion In this randomized controlled trial, combination CurQD was found to be effective for inducing remission in active UC patients. Induction of AhR may merit further study as a potential treatment target in active UC
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- 2023
6. P173 Patency capsule: A novel independent predictor for long-term outcomes among patients with quiescent Crohn’s disease
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O Ukashi, U Kopylov, B Ungar, O Haj-Natour, L Selinger, S Neuman, H Yanai, I Dotan, D Yablecovitch, A Lahat, R Eliakim, and S Ben-Horin
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Gastroenterology ,General Medicine - Abstract
Background Patency capsule (PC) is a recommended procedure to rule-out small-bowel stenosis before video capsule endoscopy (VCE).We examined future clinical outcomes among patients with failed-PC versus patients in whom PC had passed (passed-PC). Methods A Post-hoc analysis of two prospective cohort studies of adult patients with quiescent small-bowel CD that underwent PC between 2013-2020. The primary composite-outcome was the need for intestinal-surgery or endoscopic-dilation during follow-up in patients with or without failed-PC. Results A total of 191 patients were included (47-failed PC, 144-passed PC, median follow-up 34.12 months). Patients with a failed-PC had higher rates of the primary composite-outcome (21.3% vs. 1.4%, Hazard ratio [HR] 20.4, 95% confidence interval [CI] 4.4-94.1, p Conclusion Clinically-stable CD patients with failed-PC have worse long-term clinical outcomes than those without, independently of CD phenotype. Standalone PC may serve as a novel, safe and affordable prognostic examination to stratify patients with CD for future risk of poor outcomes and potentially guide pre-emptive management decisions.
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- 2023
7. P032 Host transcriptome signatures in human fecal-washes predict histological remission in IBD patients
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B Ungar, M Yavzori, E Fudim, O Picard, U Kopylov, R Eliakim, D Shouval, Y Levin, A Savidor, S Ben-Moshe, R Manco, S Dan, A Egozi, K Bahar Halpern, C Mayer, I Barshak, S Ben-Horin, and S Itzkovitz
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Gastroenterology ,General Medicine - Abstract
Background Colonoscopy is the gold standard for evaluation of inflammation in inflammatory bowel diseases (IBD), yet entails cumbersome preparations and risks of injury. Existing non-invasive prognostic tools are limited in their diagnostic power. Moreover, transcriptomics of colonic biopsies have been inconclusive in their association with clinical features. Our aim was to assess the utility of host transcriptomics of fecal wash samples of IBD patients compared to controls. Methods In this prospective cohort study, we obtained biopsies and fecal-wash samples from IBD patients and controls undergoing lower endoscopy. We performed RNAseq of biopsies and matching fecal-washes, and associated them with endoscopic and histological inflammation status. We also performed fecal mass-spectrometry proteomics on a subset of samples. We inferred cell compositions using computational deconvolution and used classification algorithms to identify informative genes. Results We analyzed biopsies and fecal washes from 39 patients (19 IBD, 20 controls). Host fecal-transcriptome carried information that was distinct from biopsy RNAseq and fecal proteomics. Transcriptomics of fecal washes, yet not of biopsies, from patients with histological inflammation were significantly correlated to one another (p=5.3*10–12). Fecal-transcriptome was significantly more powerful in identifying histological inflammation compared to transcriptome of intestinal biopsies (150 genes with area-under-the-curve >0.9 in fecal samples versus 10 genes in biopsy RNAseq). Fecal samples were enriched in inflammatory monocytes, regulatory T cells, natural killer-cells and innate lymphoid cells. Figure 1 - Fecal-wash host transcriptome predicts histological inflammation. A) Study layout, B) Clustergram of fecal-wash host cell mRNA signatures, demonstrating that patients with histological inflammation (red) are clustered when measuring fecal wash transcriptome yet not biopsy transcriptomes. C-D) Principle Component Analysis demonstrating improved separation of inflamed patients based on fecal host transcriptomes. E, F) Expression of host genes in fecal washes has higher statistical power (Area under the Curve, AUC) in classifying histological inflammation compared to biopsies. D shows NFKBIA as an example, E shows the AUC of the 5% best classifying genes, F shows the overall AUC based on biopsies or washes. Gray areas have AUC>0.9. G) UMAP of cells obtained from scRNAseq of mouse small intestine fecal washes. Conclusion Fecal wash host transcriptome is a powerful biomarker reflecting histological inflammation. Furthermore, it opens the way to identifying important correlates and therapeutic targets that may be obscure using biopsy transctriptomics.
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- 2022
8. P192 First event of acute intestinal inflammation and the risk of progression to Inflammatory bowel disease: a retrospective analysis
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A Levartovsky, T Ovdat, Y Barash, Z Ben-Shatach, Y Skinezes, S Jesin, R Klempfner, E Grossman, U Kopylov, S Ben-Horin, and B Ungar
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Gastroenterology ,General Medicine - Abstract
Background Episodes of acute ileitis or colitis have been associated with future development of inflammatory bowel diseases (IBD). Nevertheless, the incidence of IBD among patients diagnosed with acute intestinal inflammation is currently unknown. We aimed to assess the risk for future development of IBD based on clinical and radiographical features of patients presenting with abdominal symptoms to the emergency department (ED) and undergoing urgent computerized tomography (CT) of the abdomen. Methods We created an electronic data repository of all patients visiting the ED at our medical center and undergoing abdominal CT between 2011–2020. We searched the computerized database for patients diagnosed with Crohn’s disease (CD) or ulcerative colitis (UC) during a visit to the gastroenterology department within maximal follow-up time of 9 years from the index-admission to the ED. Statistical analysis including multivariate models identified the risk and possible predictors of patients to develop IBD. Results Overall, 1551 patients visited the ED and underwent abdominal imaging with abnormal findings. The radiographic parameters reported the most on abdominal CT scans were bowel wall thickening, fat infiltration, and abdominal free fluid. Twenty-three patients (1.5%) were eventually diagnosed with IBD (19 CD, 4 UC) at gastroenterological follow-up with a median of 60 days (IQR 30–120) from the time of the ED admission. Patients with a future IBD diagnosis were significantly younger (28 vs 51 years, p Conclusion IBD would be eventually diagnosed only in a minority of patients presenting with ileitis or colitis on abdominal CT. Younger age, diarrhea as a presenting symptom and colitis on imaging are predisposing factors.
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- 2022
9. OP10 Response to biologics in IBD patients assessed by Computerized image analysis of Probe Based Confocal Laser Endomicroscopy with molecular labeling and gene expression profiling
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B Ungar, Andrea Buda, Marietta Iacucci, Davide Zardo, Olga Maria Nardone, Louisa E. Jeffery, Samuel C. Smith, Enrico Grisan, Animesh Acharjee, N Labarile, Georgios V. Gkoutos, Uday N. Shivaji, Rosanna Cannatelli, and G Subrata
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Confocal laser endomicroscopy ,Pathology ,medicine.medical_specialty ,Standard of care ,Tumor necrosis factors ,business.industry ,Gastroenterology ,Endoscopic surgery ,General Medicine ,Computer assisted image analysis ,Gene expression profiling ,Area under curve ,Medicine ,business ,Fluorescein-5-isothiocyanate - Abstract
Background Biologics are being used increasingly in the treatment of Inflammatory Bowel Disease. However, up to 40% of patients do not respond to biologics. Therefore, methods to predict response are imperative. We aimed to identify novel genes and pathways predictive of anti-TNF response in patients with Ulcerative Colitis (UC) undergoing electronic chromoendoscopy and probe confocal laser endomicroscopy (pCLE). We further evaluated the ex-vivo binding of fluorescent labelled biologics as markers of response Methods 26 UC patients starting anti-TNF therapy as standard of care were recruited. Pre-treatment colonoscopy, with electronic chromoendoscopy and pCLE (Cellvizio, Mauna Kea) by injecting intravenous fluorescein (2.5-5mls), was performed to assess disease activity. Targeted biopsies were taken for fluorescein isothiocyanate (FITC)-labelled infliximab staining and RNA extraction and gene expression analysis. Ex vivo labelling was evaluated by an automated analysis: after a first pre-processing step to remove biases, the labelled regions were identified using statistical multi-level thresholding, and evaluated as area and intensity. To assess response, the same endoscopic procedure was repeated at week 12–14 after anti-TNF. cDNA libraries were prepared using QIAseq UPX 3’Transcriptome reagents and sequenced. Normalised gene expressions were obtained through the CLC Genomics Workbench. Differentially expressed genes (DEGs) (FDR-corrected P-value Results At baseline increased binding of the labelled biologic was associated with a higher likelihood of response to treatment (AUROC81%, accuracy77%, PPV100%, NPV63%). 342 DEGs (75 up-regulated, 267 down-regulated) distinguished responders from non-responders, 76 fell within enriched pathways. Pathways related to inflammation, chemotaxis, TGF-beta signalling, extracellular matrix and carbohydrate metabolism were reduced and cell-cell adhesion increased in responders pre-treatment. Among the 37 genes with VIP>1, CRIP2, CXCL6,EMILIN1,GADD45B, LAMA4 and MAPKAPK2 were upregulated in non-responders pre-treatment and were good predictors of response (AUROC>0.7) in this cohort and validation cohort Conclusion A higher mucosal binding of the biologics before treatment was observed in anti-TNF responders. Responsive UC patients have a less inflamed and fibrotic state pre-treatment. Chemotactic pathways, involving CXCL6 may be novel targets to treat non-responders
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- 2021
10. P421 Correlation of bowel activity parameters in intestinal ultrasound to drug retention and trough drug levels in Crohn’s disease
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A Albshesh, B Ungar, U Kopylov, S Ben-Horin, and D Carter
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Gastroenterology ,General Medicine - Abstract
Background Introduction: Intestinal ultrasound can be used to assess transmural healing and response in Inflammatory bowel disease (IBD). Bowel wall thickness (BWT) appears to be the most applicable parameter for defining inflammation. Other parameters include amplified color Doppler signal, disappearance of the normal bowel wall layers and proliferation of mesenteric fat. The implication of incorporating these parameters in defining transmural healing and response is not clear. Our aim was to examine the significance of combining these parameters with BWT for defining transmural healing and response. Methods: Methods A post-hoc analysis of data from, 2 trials was used to examine the correlation of the different IUS parameters on drug retention and trough drug levels. Results: Results The study cohort included, 94 patients (median age, 24.5) with Crohn’s disease., 44 patients were treated with adalimumab (ADA) and, 50 with infliximab (IFX). There was a significant correlation of failure of drug retention and terminal ileum (TI) BWT >, 3 mm (P=0.07), amplified doppler sign (p7.1, IFX>5) and terminal ileum BWT Conclusion Conclusions: Increased BWT was correlated with failure of drug retention. The addition of other ultrasonographic activity parameters did not significantly improve the predictive model. Therefore, TI-BWT should be used as the main target in the definition of transmural healing and response.
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- 2022
11. P160 Pan-enteric mucosal inflammation in CD patients treated with vedolizumab – interim results of a prospective observational study using a panenteric capsule (PiilCam CD)
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U Kopylov, M Lipkin, B Ungar, O Haj, E Shachar, A Lahat, S Ben-Horin, and R Eliakim
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Gastroenterology ,General Medicine - Abstract
Background Mucosal healing is associated with improved short- and long-term outcomes in Crohn’s disease (CD). However, the likelihood of reaching mucosal healing differs between segments of the mucosal tract. The prevalence of panenteric mucosal healing is scarcely described. Capsule endoscopy is the prime modality for evaluation of the entire small bowel. Recently, a combined pan-enteric capsule (PillCam Crohn’s capsule (PCCD) that enables evaluation of mucosal inflammation in the entire digestive tract in a single procedure, has been developed. The main aim of our study was to evaluate the rate of panenteric mucosal healing in Crohn’s disease patients treated with vedolizumab (VDZ) after 52 weeks of therapy. The current interim report focuses on the rates of mucosal improvement after 14 weeks of VDZ treatment. Methods This was a prospective open- label observational study. Patients starting vedolizumab (VDZ) for Crohn’s disease underwent a patency capsule (PC) and if it was excreted within 30 hours, enrolled in the study. The patients were evaluated with PCCD at week 0, 14 and 52 of VDZ treatment. Mucosal inflammation was quantified using the Lewis score (LS) and the panenteric Pillcam score (PS). In addition, fecal calprotectin (FC) and CRP levels were measured at each visit. Patients without active mucosal inflammation on week 0 PCCD were excluded from further participation Results We enrolled 30 patients; 5/30 failed PC and were dropped out of the study.Twenty five patients underwent PCCD at week 0 and 19/25 (78%)% -at week14 (six patients were dropped out for either absence of active mucosal inflammation at week 0 (1 patient), treatment discontinuation before week 14 (2 patients) endoscopic activity – 1, withdrawal of consent (1 patient) or loss to follow-up (1 patient)). After 14 weeks of VDZ treatment, there was a significant improvement in LS (median of 900 (interquartile ration (IQR)- 1143)), vs 450 (IQR-750), p=0.013), ES (15 (IQR-18) vs 10 (IQR-11), p=0.012) and FC (996 (IQR-455) vs 742 (IQR -740), p=0.012), while CRP levels were not significantly different. Conclusion VDZ induces significant improvement in mucosal inflammation evaluated by panenteric capsule endoscopy, in addition to a significant improvement in FC levels, after 14 weeks of therapy *The study was supported by IIR grant from Takeda and Medtronic
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- 2022
12. P484 Do vedolizumab trough levels predict response to consecutive therapy in Inflammatory Bowel Disease?
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A Levartovsky, I Cohen, C M Abitbol, M Yavzori, E Fudim, O Picard, U Kopylov, S Ben-Horin, and B Ungar
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Gastroenterology ,General Medicine - Abstract
Background Vedolizumab trough serum levels have been associated with clinical and endoscopic response in patients with inflammatory bowel disease (IBD), albeit findings have not been conclusive. A recent study demonstrated that higher trough vedolizumab levels before therapy escalation predict optimal outcome. Our aim was to identify whether vedolizumab trough levels predict outcome of consecutive biologic or immunomodulatory therapy. Methods This retrospective study included IBD patients consecutively receiving vedolizumab therapy between November 2014 and June 2021 at Sheba Medical Center. Only patients who lost response to vedolizumab therapy, and had available trough levels prior to therapy cessation were included. Clinical and endoscopic scores, as well as drug retention, were recorded at 6 and 12 months post switching therapy. Results Overall, 66 IBD patients (36 CD, 30 UC) who lost response to vedolizumab therapy were included. They were treated with vedolizumab for a median of 47 weeks (IQR 31–85). Seventy-two percent of patients (48/66) were priorly treated with anti-TNF therapy (infliximab or adalimumab). After vedolizumab cessation, 66.7% of patients were switched to biologic therapy. These included 25.8% (17/66) to ustekinumab, 22.7% (15/66) to infliximab, 7.6% (5/66) to adalimumab, 6.1% (4/66) to certolizumab and 4.5% (3/66) to golimumab. The remaining 33.3% of patients switched to tofacitinib (10.6%), 5-ASA derivates or immunomodulator monotherapy (12.1%) or to a study therapy protocol (10.6%). Median vedolizumab trough levels at therapy cessation were 32.25 μg/ml (IQR 12.8–61.4). Trough drug levels at therapy cessation were not associated with retention of biological or immunomodulatory therapy at 6 months [median 29.1 μg/ml (IQR 12.4–57.6) vs 33.8 μg/ml (IQR 27.9–58), p = 0.43] and at 12 months [median, 38.2 μg/ml (IQR 14.5–76.3) vs 30.1 μg/ml (IQR 11.5–45), p = 0.57] for patients who retained consecutive therapy versus those who did not. Conclusion Vedolizumab trough serum levels before therapy cessation due to loss of response do not predict retention of consecutive therapy.
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- 2022
13. P381 Factors predicting risk of colectomy in patients receiving first line steroid and second line biologic salvage therapy for Acute Severe Ulcerative Colitis
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Y Skinezes, Z Y Meir, C M Abitbol, A Levartovsky, E Klang, U Kopylov, S Ben-Horin, and B Ungar
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Gastroenterology ,General Medicine - Abstract
Background Acute severe ulcerative colitis (ASUC) is considered a medical emergency and is associated with high rates of colectomy and even death. Intra-venous corticosteroids serve as first line therapy for ASUC. Patients who fail to respond will progress to rescue therapy, comprised of either medical therapy (with Cyclosporine or Infliximab) or colectomy. We aimed to detect factors predictive of first and second line therapy failure in patients hospitalized for ASUC. Methods The Sheba Medical Center database was screened for all hospitalized UC patients between, 2009–2019. All clinical, demographic and laboratory parameters were retrieved from patients’ medical files. All parameters were compared between patients either responding to or failing corticosteroids / second line therapy, respectively. All statistical analyses were performed using the MEDCALC software. Results 159 hospitalized ASUC patients were identified (117, 73.6% responded to IV corticosteroids;, 42, 26.4% failed first line therapy). 4 (9.5%) of those who failed first line therapy underwent colectomy. The only factor predisposing for corticosteroid therapy failure was pervious biological therapy. No statistically significant difference was observed in terms of MAYO score at admission, UC location, smoking, previous hospitalizations, hemoglobin levels or fever upon admission., 25 patients responded to second line biological therapy (15 Infliximab, 8 Cyclosporine, 2 Tofacitinib) while, 13 failed this therapy (6 Infliximab, 7 Cyclosporine). The only factors predicting second line therapy failure were previous biological therapy (p=0.01) and pancolitis at presentation (p=0.04). Conclusion ASUC patients previously treated with biologics and who had pancolitis at diagnosis are at higher risk of second line therapy failure and colectomy.
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- 2022
14. N05 Patient involvement in Inflammatory Bowel Disease therapy and disease-related parameters - Is there an association?
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O Haj Natour, R Magnezi, S Ben Horin, M Lipkin, B Ungar, A Galper, S Sina, and U Kopylov
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Gastroenterology ,General Medicine - Abstract
Background Recent studies have demonstrated the importance of involving patients afflicted by a chronic disease in their own medical therapy with respect to disease control, compliance and general quality of life. Patient activation refers to patients’ independence in daily activities, involvement in the therapeutic process and having the knowledge, skills, and confidence to manage their health and health care. This study examined the association between the degree of activation of patients with inflammatory bowel disease (IBD) and its effect on health indices Methods This prospective longitudinal study included patients with Crohn’s Disease (CD) or ulcerative colitis (UC) treated at Sheba Medical Center, Israel. The patients answered questionnaires weekly during a period of 8 months using an application installed on their personal mobile phone. The questionnaires addressed clinical and emotional disease parameters, patient’s sense of disease-control (IBD-control), quality of life (short IBD quality of life questionnaire (S-IBDQ) and patient activation measure (PAM), a 4-level model of health behavior. The lowest level indicates that the patient may not believe his/her role in self-care management is important; the second level indicates that the patient lacks confidence or knowledge to take an active role; the third level indicates that the patient is beginning to be active; and the at highest level, patients actively attempt (even with difficulty) to maintain health management behaviors over time. Demographic and medical information, as well as clinical data were retrieved from the medical records. Results Among 356 IBD patients, 208 (58%) answered all questionnaire items and were included in the study 159 (76%) had CD, and 49 (24%) UC, 116 (56%) women and 92 (44%) men). Median scores of the questionnaires were as follows: PAM -63, IQR- 52.9–70.8; SIBDQ- median 44, interquartile ratio (IQR) 40–75; IBD-control 62.4, IQR- 45.7–82. 2 IBD-control mental health component- 47, IQR- 41.1–53.3). PAM was significantly correlated with questionnaires associated with overall well-being, emotional status and quality of life (SIBDQ -r=0.34 p=0.0001, IBD-control -r=0.24, p=0.004 and PROMIS-mental health component r=0.48, p Conclusion Intensive weekly mobile-App based monitoring program was feasible and adhered to by most patients. PAM scores correlated significantly with their sense of disease-control and mental health scores. Hence, IBD patients’ involvement in medical therapy increases their self-management, sense of disease-control and emotional well-being.
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- 2022
15. P515 Inflammatory bowel disease and malignancy – the outcome of patients with malignancy diagnosed before IBD diagnosis or IBD-targeted therapy
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U Shani, E Klang, B Ungar, S Ben-Horin, and U Kopylov
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Gastroenterology ,General Medicine - Abstract
Background The treatment strategy in IBD patients with previous malignancy is not well defined, and the available literature is scarce.The main aim of this study was to describe the outcome of IBD patients with previous malignancy or before exposure to IBD-related treatment. Methods The study cohort included IBD patients with at least one malignancy diagnosed before IBD or before initiation of IBD-related treatment (excluding 5-ASA/corticosteroids). All patients were followed at the department of gastroenterology in Sheba medical center between 2010 and 2021. Clinical and demographic data were extracted from the patients’ medical records. The main outcome of interest was a relapse of previous malignancy or the development of a second malignancy. Results From our IBD database comprising 3811 patients, we identified 86 patients with malignancy before IBD-related treatment: 38 diagnosed with malignancy 6 years before IBD (median time, IQR=3–12) and 48 - after (15 years (IQR7-22) IBD diagnosis but before exposure to IBD treatment. The most common malignancy preceding IBD was breast cancer found in 9/38 (24%) patients. Other malignancies before IBD diagnosis included: lymphoma 7/38 patients (18%), melanoma in 6 patients (16%), and leukemia in 4 patients (11%). After a diagnosis of IBD, 38/86 (44%) patients were treated with thiopurines, 28/86 (32%) with vedolizumab (VDZ), and 26/86 (30%) with anti-TNFs. 10/86 (9%) patients were further diagnosed with second primary malignancy. The median time from first to second malignancy was 7 years (IQR=16-6); 7/10 patients (70%) were exposed to thiopurines, 6/10 (60%) to anti-TNFs, and 6/10 (60%) to VDZ. The only clinical variable associated with second malignancy was female gender (9/40 (22.5%) vs. 1/46 (2.2%), p=0.005). 20/86 patients (23%) had a recurrence of malignancy (median- 3 years (IQR=3–9). The most common recurrent malignancies were non-melanotic skin cancer (NMSC) In 9 patients (45%) and melanoma in 3 patients (20%). Of patients with recurrence, 11 patients (55%) were exposed to thiopurines, 10 patients (50%) were exposed to anti-TNFs, and 5 patients (25%) were exposed to vedolizumab. Treatment with anti-TNFs was associated with recurrence of NMSC (6/25 (24%) vs. 2/52 (3.7%), p=0.047). Conclusion In our retrospective tertiary center cohort, recurrence of malignancies in IBD patients with previous neoplasia was uncommon. However, most recurrent malignancies were solid and hematopoietic malignancies. Female gender was associated with an increased risk of second malignancy, while anti-TNF treatment was associated with an increased risk of NMSC recurrence. Our findings underline the importance of rigorous dermatological follow-up in IBD patients with previous NMSC treated with anti-TNFs
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- 2022
16. The IBEX Flight Segment
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J. Crock, E. Fowler, E. Walter, C. Loeffler, T. Gaio, W. Holemans, M. Epperly, J. Gerhardus, M. Phillips, B. Ungar, G. Rahal, S. Pope, B. Hautamaki, Jennifer Hanley, Mark B. Tapley, S. Wesley, T. Wiegand, T. Perry, W. Cross, D. Hawes, A. Dunn, M. Peterson, John Scherrer, R. Tyler, A. DeLosSantos, S. Kinaman, A. Osovets, David J. McComas, B. Fields, S. Kirn, G. Dunn, W. Grossman, and John Carrico
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Attitude control ,Spacecraft ,Space and Planetary Science ,business.industry ,Launched ,Astronomy and Astrophysics ,Adapter (rocketry) ,Solid-fuel rocket ,Propulsion ,Aerospace engineering ,business ,Heliosphere ,Mission assurance - Abstract
IBEX provides the observations needed for detailed modeling and in-depth understanding of the interstellar interaction (McComas et al. in Physics of the Outer Heliosphere, Third Annual IGPP Conference, pp. 162–181, 2004; Space Sci. Rev., 2009a, this issue). From mission design to launch and acquisition, this goal drove all flight system development. This paper describes the management, design, testing and integration of IBEX’s flight system, which successfully launched from Kwajalein Atoll on October 19, 2008. The payload is supported by a simple, Sun-pointing, spin-stabilized spacecraft with no deployables. The spacecraft bus consists of the following subsystems: attitude control, command and data handling, electrical power, hydrazine propulsion, RF, thermal, and structures. A novel 3-step orbit approach was employed to put IBEX in its highly elliptical, 8-day final orbit using a Solid Rocket Motor, which provided large delta-V after IBEX separated from the Pegasus launch vehicle; an adapter cone, which interfaced between the SRM and Pegasus; Motorized Lightbands, which performed separation from the Pegasus, ejection of the adapter cone, and separation of the spent SRM from the spacecraft; a ShockRing isolation system to lower expected launch loads; and the onboard Hydrazine Propulsion System. After orbit raising, IBEX transitioned from commissioning to nominal operations and science acquisition. At every phase of development, the Systems Engineering and Mission Assurance teams supervised the design, testing and integration of all IBEX flight elements.
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- 2009
17. Beyond Avoidance: Advanced Therapies for Contact Dermatitis
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Yin, Lu, Ungar, Benjamin, Guttman-Yassky, Emma, Cohen, David E., and Karagounis, Theodora K.
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- 2024
- Full Text
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18. Stumped by Headlines: Investigating a Functional Knowledge Deficit
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Sheldon B. Ungar
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Knowledge society ,Knowledge economy ,Knowledge level ,media_common.quotation_subject ,Ignorance ,Education ,Epistemology ,Reading (process) ,Specialization (logic) ,Knowledge deficit ,Information society ,Psychology ,Social psychology ,media_common - Abstract
Competing claims about the level of ignorance, or knowledge, among the current Nexus generation are addressed. The core of the paper is a theoretical analysis of ignorance in the knowledge society. Specifically, the knowledge-ignorance paradox suggests that the intense specialization demanded by a knowledge economy militates against a broader information society and gives rise to "reading reluctance." To provide evidence for this analysis, the results of a small-scale study testing the idea of a "functional knowledge deficit" are presented. Students were asked to identify metaphorical terms that are commonly used without definition in newspaper captions. The results revealed that students could only identify about 30% of these common expressions, and that they did not do better with terms derived from computers or the popular culture. Significant differences were also found between male and female responses. Both the implications of the findings and further avenues of research are discussed.
- Published
- 2002
19. Identification of Potential Hub Genes in Alopecia Areata.
- Author
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Liu R, Liu L, Xu J, Wen X, Jiang Y, Qi Q, Qin J, and Qin P
- Subjects
- Humans, Gene Expression Profiling, RNA, Messenger genetics, RNA, Messenger metabolism, Case-Control Studies, Databases, Genetic, Alopecia Areata genetics, MicroRNAs genetics, MicroRNAs metabolism, RNA, Long Noncoding genetics, Gene Regulatory Networks, Protein Interaction Maps genetics
- Abstract
Alopecia areata (AA) is an immune-mediated chronic alopecia disease, but its specific pathogenesis is unclear. Gene expression data for AA patients (AAs) and healthy controls (HCs) were retrieved from the GEO database, and the differentially expressed genes (DEGs) between AAs and HCs were identified. Then, GO, KEGG and GSEA analysis were performed. A PPI network for the DEGs was then constructed to screen for hub genes, which were validated by three additional datasets. Subsequently, the potential miRNAs interacting with the hub genes were obtained through TarBase and miRNet. The differentially expressed lncRNAs (DElncRs) were obtained for subcellular localisation analysis, and the DElncRs located in the cytoplasm were further screened to identify miRNAs that interact with them. The shared miRNAs interacting with the hub genes and lncRNAs were used to construct a network of mRNA-miRNA-lncRNA interactions. Lastly, ROC analysis was performed to evaluate the potential diagnostic value of the hub genes and DElncRs identified. A total of 173 DEGs were obtained, mainly enriched in cytokines, chemokines, hair follicle development and hair cycle related signalling pathways. Through PPI screening and validation based on 3 additional datasets, 24 hub genes were finally yielded. Of them, five hub genes were upregulated and the potential miRNAs that interact with these five hub genes were identified. Additionally, 26 DElncRs were obtained, including 9 upregulated lncRNAs located in the cytoplasm that were predicted to interact with the miRNAs. Finally, an mRNA-miRNA-lncRNA regulatory network was constructed using five hub genes, four lncRNAs and their shared five miRNAs. The regulatory relationship between CD8A, mir-185-5p and FOXD2-AS1 might be crucial in AA pathogenesis, with CD8A and FOXD2-AS1 exhibiting diagnostic potential. CD8A and FOXD2-AS1 may serve as potential therapeutic targets in AA., (© 2024 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.)
- Published
- 2024
- Full Text
- View/download PDF
20. The IBEX Flight Segment
- Author
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J. Scherrer, J. Carrico, J. Crock, W. Cross, A. DeLosSantos, A. Dunn, G. Dunn, M. Epperly, B. Fields, E. Fowler, T. Gaio, J. Gerhardus, W. Grossman, J. Hanley, B. Hautamaki, D. Hawes, W. Holemans, S. Kinaman, S. Kirn, C. Loeffler, D. J. McComas, A. Osovets, T. Perry, M. Peterson, M. Phillips, S. Pope, G. Rahal, M. Tapley, R. Tyler, B. Ungar, E. Walter, S. Wesley, and T. Wiegand
- Published
- 2009
21. Economic Evaluation of Early Interventions for Autistic Children: A Scoping Review.
- Author
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Pye K, Jackson H, Iacono T, and Shiell A
- Subjects
- Humans, Child, Early Intervention, Educational economics, Early Intervention, Educational methods, Child, Preschool, Behavior Therapy economics, Behavior Therapy methods, Autistic Disorder therapy, Autistic Disorder economics, Cost-Benefit Analysis methods
- Abstract
Many autistic children access some form of early intervention, but little is known about the value for money of different programs. We completed a scoping review of full economic evaluations of early interventions for autistic children and/or their families. We identified nine studies and reviewed their methods and quality. Most studies involved behavioral interventions. Two were trial-based, and the others used various modelling methods. Clinical measures were often used to infer dependency levels and quality-adjusted life-years. No family-based or negative outcomes were included. Authors acknowledged uncertain treatment effects. We conclude that economic evaluations in this field are sparse, methods vary, and quality is sometimes poor. Economic research is needed alongside longer-term clinical trials, and outcome measurement in this population requires further exploration., (© 2023. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)
- Published
- 2024
- Full Text
- View/download PDF
22. Enzyme-linked immunosorbent assay for the detection of Cryptosporidium parvum IgG in the serum of cats
- Author
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M R, Lappin, B, Ungar, B, Brown-Hahn, C M, Cooper, M, Spilker, M A, Thrall, S L, Hill, J, Cheney, and G, Taton-Allen
- Subjects
Cryptosporidium parvum ,Colorado ,Antibodies, Protozoan ,Cryptosporidiosis ,Antigens, Protozoan ,Enzyme-Linked Immunosorbent Assay ,Cross Reactions ,Cat Diseases ,Specific Pathogen-Free Organisms ,Feces ,Immunoglobulin G ,Cats ,Prevalence ,Animals - Abstract
The objective was to develop an enzyme-linked immunosorbent assay (ELISA) for the detection of Cryptosporidium parvum IgG in the serum of cats. The ELISA was an indirect ELISA using soluble C. parvum oocyst antigens and a peroxidase-labeled anti-feline IgG secondary antibody. Sera from cats with Toxocara felis, Giardia spp., Aelurostrongylus abstrusus, Isospora felis, Isospora rivolta, Toxoplasma gondii, or Taenia spp. infections were assayed in specificity studies. Following optimization, the ELISA and fecal examination for oocysts were performed on samples from 170 client-owned or humane society source cats and 1 cat inoculated orally with C. parvum oocysts. Cryptosporidium parvum oocysts were detected in feces (4/170; 2.4%), and C. parvum IgG was detected in serum (26/170; 15.3%) from naturally exposed cats. The seroprevalence data suggest that some cats in the geographical area studied were exposed to C. parvum, but persistent oocyst shedding was less common. The ELISA is not useful for predicting oocyst shedding in individual cats.
- Published
- 1997
23. In vitro screening of therapeutic agents against Cryptosporidium: hyperimmune cow colostrum is highly inhibitory
- Author
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T, Flanigan, R, Marshall, D, Redman, C, Kaetzel, and B, Ungar
- Subjects
Acquired Immunodeficiency Syndrome ,Colostrum ,Blotting, Western ,Animals ,Cryptosporidium ,Humans ,Cattle ,Enzyme-Linked Immunosorbent Assay ,Cell Line - Abstract
An in vitro model of Cryptosporidium parvum infection was developed utilizing an adherent human intestinal epithelial cell line HT29.74. The efficacy of potential immunologic therapy in the form of Cryptosporidium-specific hyperimmune bovine colostrum was evaluated for the ability to inhibit in vitro infection. Oocysts were purified from stool of chronically infected AIDS patients. Hyperimmune colostrum obtained from cows immunized with Cryptosporidium and nonimmune conventional colostrum were evaluated. oocysts (10(5)-10(6)) were pre-incubated with either hyperimmune colostrum, conventional colostrum, or saline as control, for 15 min at room temperature than applied to a 70% confluent monolayer of HT29.74 cells. Cryptosporidium schizonts were identified and counted per 1,000 HT29.74 cells under oil immersion after 24 h. In the presence of hyperimmune colostrum, parasite infection was inhibited by 82% (p less than 0.001), and the presence of conventional colostrum, infection was inhibited by 67% (p less than 0.001). Treatment with the soluble fraction of hyperimmune colostrum resulted in 69% inhibition (p less than 0.001) compared to the soluble fraction of conventional colostrum which resulted in only 17% inhibition (p = NS). In vitro Cryptosporidium parvum infection of the differentiated human enterocyte cell line HT29.74 is a viable method for screening immunologic therapies. Hyperimmune bovine colostrum was highly inhibitory of Cryptosporidium infection in vitro and its soluble fraction remained significantly inhibitory while the soluble fraction of conventional colostrum did not.
- Published
- 1991
24. Silencing of Science: The Phenomenon and its Impact on Passive Smoking Epidemiology
- Author
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S B Ungar
- Subjects
Toxicology ,medicine.medical_specialty ,Passive smoking ,Epidemiology ,business.industry ,Phenomenon ,medicine ,Gene silencing ,business ,medicine.disease_cause ,Psychiatry - Published
- 2006
25. Reassessment of the Long-Term Mortality Risks of Active and Passive Smoking
- Author
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S B Ungar, J E Enstrom, and G C Kabat
- Subjects
Passive smoking ,Epidemiology ,business.industry ,Environmental health ,Medicine ,Long term mortality ,business ,medicine.disease_cause - Published
- 2006
26. Dupilumab Improves Clinical Scores in Children and Adolescents With Moderate to Severe Atopic Dermatitis: A Real-World, Single-Center Study
- Author
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Pagan, Angel D., David, Eden, Ungar, Benjamin, Ghalili, Sabrina, He, Helen, and Guttman-Yassky, Emma
- Published
- 2022
- Full Text
- View/download PDF
27. A Vector Space Approach for Measuring Relationality and Multidimensionality of Meaning in Large Text Collections.
- Author
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Poschmann, Philipp, Goldenstein, Jan, Büchel, Sven, and Hahn, Udo
- Subjects
NATURAL language processing ,VECTOR spaces ,VECTOR analysis ,ORGANIZATIONAL sociology ,ORGANIZATIONAL research - Abstract
In this article, we develop a methodological approach for organizational research regarding the construction of multidimensional and relational similarity measures by using the vector space model in natural language processing (NLP). Our vector space approach draws on the well-established premise in organizational research that texts provide a window into social reality and allow measuring theory-based constructs (e.g., organizations' self-representations). Using a vector space approach allows capturing the multidimensionality of these theory-based constructs and computing relational similarities between organizational entities (e.g., organizations, their members, and subunits) in social spaces and with their environments, such as the organization itself, industries, or countries. Thus, our methodological approach contributes to the recent trend in organizational research to use the potential inherent in big (textual) data by using NLP. In an example, we provide guidance for organizational scholars by illustrating how they can ensure validity when applying our methodological contribution in concrete research practice. [ABSTRACT FROM AUTHOR]
- Published
- 2024
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- View/download PDF
28. Assessing the Impact of ChatGPT in Dermatology: A Comprehensive Rapid Review.
- Author
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Goktas, Polat and Grzybowski, Andrzej
- Subjects
LANGUAGE models ,NATURAL language processing ,CHATGPT ,DATA privacy ,ARTIFICIAL intelligence - Abstract
Background/Objectives: The use of artificial intelligence (AI) in dermatology is expanding rapidly, with ChatGPT, a large language model (LLM) from OpenAI, showing promise in patient education, clinical decision-making, and teledermatology. Despite its potential, the ethical, clinical, and practical implications of its application remain insufficiently explored. This study aims to evaluate the effectiveness, challenges, and future prospects of ChatGPT in dermatology, focusing on clinical applications, patient interactions, and medical writing. ChatGPT was selected due to its broad adoption, extensive validation, and strong performance in dermatology-related tasks. Methods: A thorough literature review was conducted, focusing on publications related to ChatGPT and dermatology. The search included articles in English from November 2022 to August 2024, as this period captures the most recent developments following the launch of ChatGPT in November 2022, ensuring that the review includes the latest advancements and discussions on its role in dermatology. Studies were chosen based on their relevance to clinical applications, patient interactions, and ethical issues. Descriptive metrics, such as average accuracy scores and reliability percentages, were used to summarize study characteristics, and key findings were analyzed. Results: ChatGPT has shown significant potential in passing dermatology specialty exams and providing reliable responses to patient queries, especially for common dermatological conditions. However, it faces limitations in diagnosing complex cases like cutaneous neoplasms, and concerns about the accuracy and completeness of its information persist. Ethical issues, including data privacy, algorithmic bias, and the need for transparent guidelines, were identified as critical challenges. Conclusions: While ChatGPT has the potential to significantly enhance dermatological practice, particularly in patient education and teledermatology, its integration must be cautious, addressing ethical concerns and complementing, rather than replacing, dermatologist expertise. Future research should refine ChatGPT's diagnostic capabilities, mitigate biases, and develop comprehensive clinical guidelines. [ABSTRACT FROM AUTHOR]
- Published
- 2024
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- View/download PDF
29. Discrimination Analysis of Conventional Baijiu-making Sorghum from Southwest China and Hybrid Sorghum Based on Physicochemical Properties and Metabolomics.
- Author
-
WANG Hongmei, LI Zhe, WANG Songtao, ZHANG Qingliang, CHEN Anjing, LI Ling, and TU Rongkun
- Subjects
HIGH performance liquid chromatography ,RECEIVER operating characteristic curves ,PRINCIPAL components analysis ,DISCRIMINANT analysis ,SORGHUM - Abstract
The objective of this paper was to analyze the difference of composition between hybrid sorghum and conventional sorghum in southwest China, and to establish the method of variety identification. The basic physical and chemical components of 29 sorghum samples were determined, and the metabolite composition of 29 sorghum samples was determined by ultra high performance liquid chromatography coupled with Q Exactive HF-X mass spectrometry. The marker component screening and construction of variety identification model were carried out using stoichiometry, which included principal component analysis (PCA), orthogonal partial least squares discriminant analysis (OPLS-DA), cluster analysis and receiver operating characteristic (ROC) curve analysis. The model was based on the basic physicochemical composition and all metabolites. The results showed that the contents of amylopectin and tannin of the conventional varieties form southwest China were higher than that of hybrid varieties, while the contents of amylose and 1000-grain weight were lower. By analyzing the physicochemical properties, it was possible to identify certain samples. The OPLS-DA model was constructed with all 1048 compounds variables, and 46 of the differential metabolites that had a significant impact on the model identification were screened out. A novel OPLS-DA identification model was developed for sorghum varieties, achieving a 100% accuracy in identification. The conventional varieties from southwest China exhibited a relatively high concentration of phenolic compounds. Furthermore, after conducting receiver operating characteristic (ROC) curve analysis and assessing the relative standard deviation (RSD) of quality control sample (QC), 20 feature components that exhibited both high diagnostic accuracy and good reproducibility were identified. Among them, syringetin 3-glucoside and 6"-o-acetyldaidzein had higher expression abundance in conventional sorghum varieties, while D-glucarate, putsutrine, N-acetylputsutrine and L-glutamine had higher content in hybrid sorghum varieties. This study unveiled the disparity in metabolites between hybrid sorghum and conventional sorghum. The study successfully developed a scientifically rigorous and precise untargeted metabolomics approach using UHPLC-Q Exactive HF-X-MS. This method can be effectively utilized for the identification of sorghum varieties, offering a novel strategy for sorghum variety identification. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
30. Ultra-High Strength in FCC+BCC High-Entropy Alloy via Different Gradual Morphology.
- Author
-
Ding, Ziheng, Ding, Chaogang, Yang, Zhiqin, Zhang, Hao, Wang, Fanghui, Li, Hushan, Xu, Jie, Shan, Debin, and Guo, Bin
- Subjects
TORSION ,ALLOYS ,HARDNESS ,DUCTILITY ,MICROSTRUCTURE - Abstract
In this study, high-pressure torsion (HPT) processing is applied to the as-cast Al
0.5 CoCrFeNi high-entropy alloy (HEA) for 1, 3, and 5 turns. Microstructural observations reveal a significant refinement of the second phase after HPT processing. This refinement effect is influenced by the number of processing turns and the distance of the processing position from the center. As the number of processing turns or the distance of the processing position from the center increases, the fragmentation effect on the second phase becomes more pronounced. The hardness of the alloy is greatly enhanced after HPT processing, but there is an upper limit to this enhancement. After increasing the number of processing turns to 5, the increase in hardness at the edge becomes less significant, while the overall hardness becomes more uniform. Additionally, the strength of the processed alloy is significantly enhanced, while its ductility undergoes a noticeable decrease. With an increase in the number of processing turns, the second phase is further refined, resulting in improvement of strength and ductility. [ABSTRACT FROM AUTHOR]- Published
- 2024
- Full Text
- View/download PDF
31. Exploring the lived experience of mothers of children with leukemia: a qualitative study from Iran.
- Author
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Shaygani, Fatemeh, Jalali, Katayoun, Javanmardi Fard, Hana, Afrasiabi, Zahra, and Ahmadi Marzaleh, Milad
- Subjects
CHILDHOOD cancer ,PSYCHOLOGICAL distress ,JUDGMENT sampling ,SEMI-structured interviews ,PARENTS - Abstract
Background: Leukemia, as one of the most common pediatric cancers, has negatively affected many children around the world. Parents often experience increased feeling of distress shortly after being informed about their child's diagnosis. The distress experienced by parents can adversely affect various aspects of their life. This study aimed to develop an understanding of the lived experience of the mothers whose children suffer from leukemia in Shiraz, Iran. Methods: This phenomenological study was performed from April to August 2023, and 10 people were selected as participants by purposive sampling. In-depth and semi-structured interviews were performed for collecting the data. Results: The participants' lived experiences during their children's leukemia were classified into five main categories, namely behavioral problems, spiritual issues, psychological problems, issues related to treatment, and economic matters. Conclusion: Knowing the experiences of parents, especially mothers, in managing and planning for the care of these children seems essential. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
32. Study of Effects of Post-Weld Heat Treatment Time on Corrosion Behavior and Manufacturing Processes of Super Duplex Stainless SAF 2507 for Advanced Li-Ion Battery Cases.
- Author
-
Lee, Yoon-Seok, Park, Jinyong, Ok, Jung-Woo, Kim, Seongjun, Shin, Byung-Hyun, and Yoon, Jang-Hee
- Subjects
ELECTRON probe microanalysis ,LASER welding ,OPEN-circuit voltage ,HEAT treatment ,ELECTRON spectroscopy ,DUPLEX stainless steel - Abstract
Lithium-ion batteries are superior energy storage devices that are widely utilized in various fields, from electric cars to small portable electric devices. However, their susceptibility to thermal runaway necessitates improvements in battery case materials to improve their safety. This study used electrochemical analyses, including open-circuit potential (OCP), potentiodynamic polarization, and critical pitting temperature (CPT) analyses, to investigate the corrosion resistance of super duplex stainless steel (SAF 2507) applied to battery cases in relation to post-weld heat treatment (PWHT) time. The microstructure during the manufacture, laser welding, and PWHT was analyzed using field-emission scanning electron microscopy, X-ray diffraction, and electron backscatter diffraction, and the chemical composition was analyzed using dispersive X-ray spectroscopy and electron probe micro-analysis. The PWHT increased the volume fraction of austenite from 5% to 50% over 3 min at 1200 °C; this increased the OCP from −0.21 V to +0.03 V, and increased the CPT from 56 °C to 73 °C. The PWHT effectively improved the corrosion resistance, laying the groundwork for utilizing SAF 2507 in battery case materials. But the alloy segregation and heterogeneous grain morphology after PWHT needs improvement. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
33. A Case Study of an Ignored Facet: Metacognitive Experiences.
- Author
-
Ozturk, Nesrin
- Subjects
EXPLORATORY factor analysis ,STUDENT teachers ,STRATEGIC planning ,METACOGNITION ,CONFIDENCE ,VOLUNTEERS - Abstract
Metacognitive experiences, a component of metacognition, may have distinctive characteristics at each instance, and they help relate and practice metacognitive knowledge and strategies. This case study examines pre-service teachers' task-specific metacognitive experiences and strategic planning performances. Data were collected from 187 volunteers via four different tasks with compatible demands and the Metacognitive Experiences Questionnaire, delivered before and after task completion. The reasons behind task selection were coded thematically, and performance scores were coded regarding the complexity of strategic planning. Findings confirmed that strategic planning performance did not vary across tasks, reasons, or class levels. Moreover, while the data did not fit the theoretical model of the Metacognitive Experiences Questionnaire, an exploratory factor analysis produced a three-factor solution for task-specific metacognitive experiences. Task-specific metacognitive experiences in this study may be represented by metacognitive estimates, feelings, and judgments, and they explained 59.5% of the variance. Post-task correctness and confidence judgments were significant predictors. While correctness judgments may facilitate performance, confidence may impose false adequacy judgments, implying the Dunning-Kruger effect. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
34. Effect of Annealing after Casting and Cold Rolling on Microstructure and Electrochemical Behavior of High-Entropy Alloy, Cantor.
- Author
-
Lim, Jinsurang, Shin, Byung-Hyun, Kim, Doo-In, Bae, Jong-Seong, Ok, Jung-Woo, Kim, Seongjun, Park, Jinyong, Lee, Je In, and Yoon, Jang-Hee
- Subjects
COLD rolling ,MATERIALS science ,MANUFACTURING processes ,METAL castings ,HEAT treatment - Abstract
High-entropy alloys (HEAs), a relatively new class of materials, have attracted significant attention in materials science owing to their unique properties and potential applications. High entropy stabilizes the phase of a solid solution over a wide range of chemical compositions, yielding unique properties superior to those of conventional alloys. Therefore, this study analyzed the microstructure and electrochemical behavior of HEAs (Cantor) to evaluate their corrosion resistance, according to their manufacturing process (casting, cold rolling, and annealing). The microstructural morphologies and sizes were analyzed using electron backscatter diffraction. The electrochemical behavior was examined using open circuit potential measurements, electrochemical impedance spectroscopy, potentiodynamic polarization tests, and critical pitting temperature measurements using a potentiostat. The casting process formed a nonuniform microstructure (average grain size = 19 μm). The cold rolling process caused the formation of fine grains (size = 4 μm). A uniform microstructure (grain size > 151 μm) was formed after heat treatment. The corrosion resistance of the HEAs was determined from the passivation layer formed by Cr oxidation. These microstructural differences resulted in variations in the electrochemical behavior. Microstructural and electrochemical analyses are crucial because HEAs have diverse potential applications. Therefore, this study contributes to future improvements in HEA manufacturing processes. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
35. Influenza Vaccination of Nursing Students: A Cross-Sectional Study of Uptake, Knowledge, Attitudes, and Practices in Greece.
- Author
-
Statiri, Anastasia, Adamakidou, Theodoula, Margari, Nikoletta, Govina, Ourania, Tsiou, Chrysoula, Giakoumidakis, Konstantinos, and Dokoutsidou, Eleni
- Subjects
ATTITUDES toward illness ,NURSING students ,VIRUS diseases ,VACCINATION coverage ,VACCINATION status - Abstract
Influenza immunization includes a yearly repeated vaccine offered to every healthcare worker, including nursing students, with a high risk of contracting this viral disease. This study aimed to investigate the vaccination coverage, knowledge, attitudes, and practices of nursing students against influenza in Greece. A cross-sectional study was conducted in the Attica region between September 2022 and July 2023, with the use of an anonymous reference questionnaire. Data from 1261 nursing students were recorded (response rate: 68.6%). The study found that 23% of the sample were vaccinated against influenza for the flu season 2022–2023, and 42% were vaccinated for the previous flu season. Knowledge scores regarding influenza ranged from 0% to 100%, with a mean value of 55 (SD = 18.8%). A higher level of knowledge about influenza was associated with more appropriate attitudes and practices toward the disease (p < 0.001). Notably, participants in their second, third, or fourth year of study and beyond exhibited more suitable attitudes and practices towards the flu compared to those in their first year of study (p < 0.05). The emergence of low vaccination coverage identifies the need for departments of nursing studies to proceed with the design of educational and intervention programs on infection control. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
36. Liquid-Crystalline Supermolecules Inducing Layer Fluctuations: From Hierarchical to Dissipative Structures.
- Author
-
Yoshizawa, Atsushi
- Subjects
LIQUID crystals ,MOLECULAR structure ,PHASE equilibrium ,SUPRAMOLECULES ,MESOGENS - Abstract
Liquid crystals, which have both liquid and solid properties, inevitably exhibit fluctuations. Some frustrated liquid-crystalline phases with a hierarchical structure, such as cybotactic nematic, modulated smectic, and bicontinuous cubic phases, are fascinating fluctuation-induced phases. In addition to these equilibrium phases, a pattern formation that is a nonequilibrium order through fluctuation is one of the most attractive research areas in soft matter. In this review, the studies on producing these fluctuation-induced orders in liquid crystals are described. Liquid-crystalline supermolecules in which several mesogens are connected via a flexible spacer have been designed. They have not only a characteristic shape but also an intra-molecular dynamic order. The supermolecules induce the fluctuations in layer structures at a molecular level, producing from the frustrated hierarchical to dynamic dissipative structures. In addition to reviewing molecular design for the hierarchical structures, the pattern propagation in a smectic phase is discussed based on the rotation of smectic blocks through Rayleigh–Bénard convection. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
37. Two cases of carcinoma of the lung characterized by a bone marrow agar culture pattern resembling acute myeloid leukemia
- Author
-
B Ungar, D. Metcalf, JH McCarthy, and J.R. Sullivan
- Subjects
Pathology ,medicine.medical_specialty ,Myeloid ,food.ingredient ,Immunology ,Myeloid leukemia ,Cell Biology ,Hematology ,Biology ,medicine.disease ,Biochemistry ,In vitro ,Leukemia ,Haematopoiesis ,medicine.anatomical_structure ,food ,medicine ,Carcinoma ,Agar ,Bone marrow - Abstract
In vitro agar culture patterns of bone marrow cells in acute myeloid leukemia may show several growth patterns, including cultures where no colonies or clusters develop, cultures with varying numbers of clusters and no colonies, or colony and cluster formation with an extremely high ratio of clusters to colonies. Twelve cases of carcinoma of the lung are described, of which two show an in vitro growth pattern of cluster formation alone, characteristic of that seen in acute myeloid leukemia. The remaining ten patients showed slightly reduced colony numbers compared to normal.
- Published
- 1979
38. The Retention Problem: An Analysis of Enrolment Attrition at a Canadian College
- Author
-
Sheldon B. Ungar
- Subjects
Medical education ,Higher education ,business.industry ,education ,medicine.disease ,Education ,Work (electrical) ,ComputingMilieux_COMPUTERSANDEDUCATION ,Mathematics education ,Economics ,medicine ,Attrition ,business ,Market value ,Financial circumstances - Abstract
A survey of returning and non-returning students at Scarborough College was undertaken to investigate the problem of declining retention rates at Ontario Universities. This study describes the opportunities available to and chosen by non-returning students, and then seeks to evaluate various hypotheses that have been proposed to account for enrolment attrition. Consistent with prior research, there was no evidence found to support the claim that students are being forced out of university by an inability to afford the costs of their education. Instead, the results suggested that enrolment attrition is produced by a combination of an attenuation of the student's commitment to obtain the degree and the student's awareness of and access to viable alternatives. As a result of a pervasive sense of uncertainty about the market value of a university degree, many students are willing to assay other opportunities. Specifically, those students who went to work appear to have been "pulled out" of university by the availability of a credible job. In addition, the contingencies affecting the commitment of the returning students and the students who transfer to other educational institutions are discussed. The conclusion addresses the relationship between financial circumstances and access to university, and raises questions about future enrolment patterns.
- Published
- 1980
39. Simple atrophic gastritis and gastric carcinoma
- Author
-
Irwin Walker, B. Ungar, I. R. Mackay, and R. G. Strickland
- Subjects
Adult ,Male ,medicine.medical_specialty ,Atrophic gastritis ,Biopsy ,medicine.medical_treatment ,Gastroenterology ,Intestinal absorption ,Pernicious anaemia ,Gastrectomy ,Stomach Neoplasms ,Internal medicine ,Anemia, Pernicious ,medicine ,Humans ,Antrum ,Pylorus ,Autoantibodies ,medicine.diagnostic_test ,business.industry ,Articles ,Middle Aged ,medicine.disease ,Vitamin B 12 ,medicine.anatomical_structure ,Intestinal Absorption ,Gastritis ,Female ,Atrophy ,medicine.symptom ,business ,Precancerous Conditions ,Follow-Up Studies - Abstract
Gastric carcinoma was detected nine, 10, 18, and 21 years after the biopsy diagnosis of atrophic gastritis in four patients of a group of 40. The gastritis was presumed to be of the simple type. Tests of vitamin B(12) absorption in three patients gave normal results, no gastric autoantibodies were detected in the two patients tested, in all patients histological examination of the gastrectomy specimens revealed a multifocal gastritis differing from the diffuse gastritis of pernicious anaemia and in three patients the gastritis affected the antrum, which is unusual in pernicious anaemia. The 10% incidence of gastric carcinoma in 40 patients with simple atrophic gastritis followed for a mean period of 15 years is equivalent to that previously described in pernicious anaemia. However, in view of the relative incidence of atrophic gastritis with and without pernicious anaemia in the general adult population, it emerges that atrophic gastritis without pernicious anaemia is numerically the more important precursor of gastric carcinoma.
- Published
- 1971
40. Abkömmlinge des Thiodiglykols, Diäthylen‐disulfids und Thioxans
- Author
-
E. Fromm and B. Ungar
- Subjects
Chemistry ,Organic chemistry - Published
- 1923
41. A columnar liquid quasicrystal with a honeycomb structure that consists of triangular, square and trapezoidal cells.
- Author
-
Zeng X, Glettner B, Baumeister U, Chen B, Ungar G, Liu F, and Tschierske C
- Abstract
Quasicrystals are intriguing structures that have long-range positional correlations but no periodicity in real space, and typically with rotational symmetries that are 'forbidden' in conventional periodic crystals. Here, we present a two-dimensional columnar liquid quasicrystal with dodecagonal symmetry. Unlike previous dodecagonal quasicrystals based on random tiling, a honeycomb structure based on a strictly quasiperiodic tessellation of tiles is observed. The structure consists of dodecagonal clusters made up of triangular, square and trapezoidal cells that are optimal for local packing. To maximize the presence of such dodecagonal clusters, the system abandons periodicity but adopts a quasiperiodic structure that follows strict packing rules. The stability of random-tiling dodecagonal quasicrystals is often attributed to the entropy of disordering when strict tiling rules are broken, at the sacrifice of the long-range positional order. However, our results demonstrate that quasicrystal stability may rest on energy minimization alone, or with only minimal entropic intervention., (© 2023. The Author(s), under exclusive licence to Springer Nature Limited.)
- Published
- 2023
- Full Text
- View/download PDF
42. Monoclonal Antibodies in the Management of Inflammation in Wound Healing: An Updated Literature Review.
- Author
-
Manzo Margiotta, Flavia, Michelucci, Alessandra, Fidanzi, Cristian, Granieri, Giammarco, Salvia, Giorgia, Bevilacqua, Matteo, Janowska, Agata, Dini, Valentina, and Romanelli, Marco
- Subjects
LITERATURE reviews ,SCIENTIFIC knowledge ,HIDRADENITIS suppurativa ,WOUND healing ,WOUND care ,CHRONIC wounds & injuries - Abstract
Chronic wounds pose a significant clinical challenge due to their complex pathophysiology and the burden of long-term management. Monoclonal antibodies (mAbs) are emerging as a novel therapeutic option in managing difficult wounds, although comprehensive data on their use in wound care are lacking. This study aimed to explore existing scientific knowledge of mAbs in treating chronic wounds based on a rationale of direct inhibition of the main molecules involved in the underlying inflammatory pathophysiology. We performed a literature review excluding primary inflammatory conditions with potential ulcerative outcomes (e.g., hidradenitis suppurativa). mAbs were effective in treating wounds from 16 different etiologies. The most commonly treated conditions were pyoderma gangrenosum (treated with 12 different mAbs), lipoid necrobiosis, and cutaneous vasculitis (each treated with 3 different mAbs). Fourteen mAbs were analyzed in total. Rituximab was effective in 43.75% of cases (7/16 diseases), followed by tocilizumab (25%, 4/16 diseases), and both etanercept and adalimumab (18.75%, 3/16 conditions each). mAbs offer therapeutic potential for chronic wounds unresponsive to standard treatments. However, due to the complex molecular nature of wound healing, no single target molecule can be identified. Therefore, the use of mAbs should be considered as a translational approach for limited cases of multi-resistant conditions. [ABSTRACT FROM AUTHOR]
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- 2024
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43. Family Life of Parents With Visual Disabilities and Their Sighted Children: How their Families Could Be Empowered From the Social Work Point of View.
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Tören, Zeliha and Gökçearslan, Elif
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SOCIAL services ,LIFE skills ,SOCIAL work with children ,FAMILIES ,SELF-efficacy ,FATHER-child relationship ,FATHERS - Abstract
Families with parents with visual disabilities and sighted children continue to be viewed with suspicion and prejudice; however, when suitable conditions are provided, these families can function in a healthy manner. Social work, as a profession, is of great importance in terms of empowering these families. The aim of this article is to understand how such families function. We interrogate how disability affects functioning and consider the circumstances under which healthy family functioning occurs. Interviews were conducted with nine mothers and nine fathers with visual disabilities, and nine sighted children in Türkiye. The findings indicate that family members' autonomy, their ability to adapt, and the social support they receive play key roles in the existence of a functional, strong family. Finally, suggestions are presented for social workers on how they can help families to make them stronger. Plain language summary: The purpose of this article is to explore how the family life of parents with visual disabilities and their sighted children function in a healthy way. To deeply understand their experience, qualitative method was chosen and interviews were carried out with nine mothers and nine fathers with visual disabilities, and nine sighted children in Türkiye. The findings indicate that family members' autonomy, their ability to adapt, and the social support they receive play key roles in the existence of a functional, strong family. The most significant limitation of the study is that almost all of the parents participating are from a particular socio-economic-cultural background and they have already gained the awareness and skills of independent living. The majority are well-educated. To overcome these difficulties, the data were evaluated from a solution-oriented perspective and the factors that empower family functioning were revealed through the existing positive examples. To empower these families, implications are presented on the basis of social work at the micro-messo and macro level. [ABSTRACT FROM AUTHOR]
- Published
- 2024
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44. Economic Evaluation of anti-epileptic Medicines for Autistic Children with Epilepsy.
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Tinelli M, Michela, Roddy, Aine, Knapp, Martin, Arango, Celso, Mendez, Maria Andreina, Cusack, James, Murphy, Declan, Canitano, Roberto, Oakley, Bethany, and Quoidbach, Vinciane
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HETEROCYCLIC compounds ,COST control ,COST effectiveness ,RESEARCH funding ,AUTISM ,FAMILIES ,DESCRIPTIVE statistics ,EPILEPSY ,CARBAMAZEPINE ,GABAPENTIN ,ASPERGER'S syndrome ,DECISION trees ,ANTICONVULSANTS ,MEDICAL care costs ,CHILDREN - Abstract
We examine the cost-effectiveness of treating epilepsy with anti-epileptic medicines in autistic children, looking at impacts on healthcare providers (in England, Ireland, Italy and Spain) and children's families (in Ireland). We find carbamazepine to be the most cost-effective drug to try first in children with newly diagnosed focal seizures. For England and Spain, oxcarbazepine is the most cost-effective treatment when taken as additional treatment for those children whose response to monotherapy is suboptimal. In Ireland and Italy, gabapentin is the most cost-effective option. Our additional scenario analysis presents the aggregate cost to families with autistic children who are being treated for epilepsy: this cost is considerably higher than healthcare provider expenditure. [ABSTRACT FROM AUTHOR]
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- 2024
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45. Can Artificial Intelligence "Hold" a Dermoscope?—The Evaluation of an Artificial Intelligence Chatbot to Translate the Dermoscopic Language.
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Karampinis, Emmanouil, Toli, Olga, Georgopoulou, Konstantina-Eirini, Kampra, Elli, Spyridonidou, Christina, Roussaki Schulze, Angeliki-Victoria, and Zafiriou, Efterpi
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CHATBOTS ,ARTIFICIAL intelligence ,DERMOSCOPY ,ACTINIC keratosis ,ALOPECIA areata ,SKIN cancer ,DYSPLASTIC nevus syndrome - Abstract
This survey represents the first endeavor to assess the clarity of the dermoscopic language by a chatbot, unveiling insights into the interplay between dermatologists and AI systems within the complexity of the dermoscopic language. Given the complex, descriptive, and metaphorical aspects of the dermoscopic language, subjective interpretations often emerge. The survey evaluated the completeness and diagnostic efficacy of chatbot-generated reports, focusing on their role in facilitating accurate diagnoses and educational opportunities for novice dermatologists. A total of 30 participants were presented with hypothetical dermoscopic descriptions of skin lesions, including dermoscopic descriptions of skin cancers such as BCC, SCC, and melanoma, skin cancer mimickers such as actinic and seborrheic keratosis, dermatofibroma, and atypical nevus, and inflammatory dermatosis such as psoriasis and alopecia areata. Each description was accompanied by specific clinical information, and the participants were tasked with assessing the differential diagnosis list generated by the AI chatbot in its initial response. In each scenario, the chatbot generated an extensive list of potential differential diagnoses, exhibiting lower performance in cases of SCC and inflammatory dermatoses, albeit without statistical significance, suggesting that the participants were equally satisfied with the responses provided. Scores decreased notably when practical descriptions of dermoscopic signs were provided. Answers to BCC scenario scores in the diagnosis category (2.9 ± 0.4) were higher than those with SCC (2.6 ± 0.66, p = 0.005) and inflammatory dermatoses (2.6 ± 0.67, p = 0). Similarly, in the teaching tool usefulness category, BCC-based chatbot differential diagnosis received higher scores (2.9 ± 0.4) compared to SCC (2.6 ± 0.67, p = 0.001) and inflammatory dermatoses (2.4 ± 0.81, p = 0). The abovementioned results underscore dermatologists' familiarity with BCC dermoscopic images while highlighting the challenges associated with interpreting rigorous dermoscopic images. Moreover, by incorporating patient characteristics such as age, phototype, or immune state, the differential diagnosis list in each case was customized to include lesion types appropriate for each category, illustrating the AI's flexibility in evaluating diagnoses and highlighting its value as a resource for dermatologists. [ABSTRACT FROM AUTHOR]
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- 2024
- Full Text
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46. IMPACT of the Social Deprivation on Psychosocial Difficulties of Pediatric Cancer Survivors: A Prospective Study.
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Delehaye, Fanny, Dejardin, Olivier, Pellier, Isabelle, Launay, Ludivine, Esvan, Maxime, Bodet, Damien, Carausu, Liana, Lejeune, Julien, Millot, Frédéric, Thomas, Caroline, Gandemer, Virginie, Alves, Arnaud, and Rod, Julien
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SCHOOL environment ,HEMATOPOIETIC stem cell transplantation ,TUMORS in children ,INDEPENDENT living ,CANCER relapse ,REHABILITATION ,INTERVIEWING ,LOGISTIC regression analysis ,DESCRIPTIVE statistics ,MULTIVARIATE analysis ,CHI-squared test ,LONGITUDINAL method ,CENTRAL nervous system tumors ,KAPLAN-Meier estimator ,CANCER chemotherapy ,RESEARCH ,CANCER patient psychology ,DATA analysis software ,CONFIDENCE intervals ,SOCIAL isolation ,PSYCHOLOGY of the sick ,SOCIAL classes ,LEARNING disabilities ,POVERTY ,DISEASE risk factors ,DISEASE complications - Abstract
Copyright of Psycho-Oncologie is the property of Tech Science Press and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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- 2024
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47. SCHOOL DIFFICULTIES in Children Cancer Survivors: A Narrative Review and a Teacher Point-of-View.
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Delehaye, Fanny, Fayet, Caroline, and Lejeune, Julien
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RE-entry students ,RISK assessment ,TUMORS in children ,ELEMENTARY schools ,CANCER patients ,HOSPITALS ,ONCOLOGY ,MUSCLE weakness ,COLLEGE teacher attitudes ,ACADEMIC achievement ,BODY movement ,PSYCHOLOGY of parents ,HOSPITAL wards ,CHILDREN - Abstract
School difficulties are common in children cancer survivors and may be prognostic for the success of the patient social reintegration after the disease. Here, we carry out a narrative review of the literature from 2001 to 2022 to assess the school difficulties of these patients, the predictive factors of these difficulties, and the possible long-term consequences. We punctuate this review the practical point-of-view of a teacher dedicated to our hospital, who works with children with chronic diseases such as cancer. Therefore, we expose possible barriers and solutions to improve the scholar reintegration and limit the impact of cancer on the academic achievement. [ABSTRACT FROM AUTHOR]
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- 2024
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48. Enhanced biosensing of tumor necrosis factor-alpha based on aptamer-functionalized surface plasmon resonance substrate and Goos–Hänchen shift.
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Borg, Kathrine Nygaard, Jaffiol, Rodolphe, Ho, Yi-Ping, and Zeng, Shuwen
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SURFACE plasmon resonance ,APTAMERS ,TUMOR necrosis factors ,DETECTION limit ,SERUM albumin ,BLOOD proteins ,PROTEIN models - Abstract
Tumor necrosis factor-alpha (TNF-α) serves as a crucial biomarker in various diseases, necessitating sensitive detection methodologies. This study introduces an innovative approach utilizing an aptamer-functionalized surface plasmon resonance (SPR) substrate together with an ultrasensitive measure, the Goos–Hänchen (GH) shift, to achieve sensitive detection of TNF-α. The developed GH-aptasensing platform has shown a commendable figure-of-merit of 1.5 × 10
4 μm per RIU, showcasing a maximum detectable lateral position shift of 184.7 ± 1.2 μm, as characterized by the glycerol measurement. Employing aptamers as the recognition unit, the system exhibits remarkable biomolecule detection capabilities, including the experimentally obtained detection limit of 1 aM for the model protein bovine serum albumin (BSA), spanning wide dynamic ranges. Furthermore, the system successfully detects TNF-α, a small cytokine, with an experimental detection limit of 1 fM, comparable to conventional SPR immunoassays. This achievement represents one of the lowest experimentally derived detection limits for cytokines in aptamer-based SPR sensing. Additionally, the application of the GH shift marks a ground breaking advancement in aptamer-based biosensing, holding significant promise for pushing detection limits further, especially for small cytokine targets. [ABSTRACT FROM AUTHOR]- Published
- 2024
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49. Challenges in IBD Research 2024: Precision Medicine.
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Syed, Sana, Boland, Brigid S, Bourke, Lauren T, Chen, Lea Ann, Churchill, Laurie, Dobes, Angela, Greene, Adam, Heller, Caren, Jayson, Christina, Kostiuk, Benjamin, Moss, Alan, Najdawi, Fedaa, Plung, Lori, Rioux, John D, Rosen, Michael J, Torres, Joana, Zulqarnain, Fatima, and Satsangi, Jack
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- 2024
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50. Comparison of the influenza vaccination coverage among high-risk people between the online registration system and walk-in service system in Bangkok, Thailand.
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Ranai Sairuk, Kimihiro Nishino, Souphalak Inthaphatha, Nobuyuki Hamajima, and Eiko Yamamoto
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INFLUENZA vaccines ,VACCINATION coverage ,THAI people ,MEDICAL personnel ,VACCINATION of children - Abstract
Until recently, the Thai national program of seasonal influenza vaccination for high-risk people has been using a walk-in service system. However, in 2020, an online registration system was introduced in Bangkok to improve vaccine coverage. This study aimed to compare the coverage of influenza vaccination between the walk-in service and online registration systems. The study participants included 374,710 Thai individuals who obtained an influenza vaccination from the national program in the Bangkok health region in 2018 (n = 162,214) and in 2020 (n = 212,496). The registration systems that were examined were the walk-in service system in 2018 and the online registration system in 2020. The characteristics of vaccine recipients and the vaccine coverage in each risk group and health facility level were compared between the two systems. Coverage comparison in Bangkok between the years 2018 and 2020 showed an increase in coverage, particularly among individuals who had an influenza vaccination at health facilities of the primary level and in the elderly and obesity groups. The coverage among children was lowest among all high-risk groups. To improve coverage in Thailand, the online registration system should be introduced in all regions. Additionally, information about influenza vaccination for children should be disseminated to parents using handbooks or by word-of-mouth from healthcare workers. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
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