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Allergic rhinosinusitis (AR) is a type 1 hypersensitivity reaction's clinical manifestation. The emergence of illness symptoms involves a variety of interactions involving immune system components such as cells, mediators, cytokines, neuropeptides, adhesion molecules, and so on. Aim of the study: to compare patient and healthy control data to see if particular blood and local cytokines, as well as IgE molecules, are involved in the etiology of AR. Materials and methods: the laboratory diagnosis in the national center laboratory in Baghdad Province, Iraq. Patients with runny noses, nasal congestion, and sneezing were enrolled in the trial with their agreement at the Allergy Specialization Center Allergy and Immunology Clinic, administered by Internal Medicine and Ear and Throat Clinics. There were 100 patients in the experimental group. A control group of 50 healthy persons in the same age range, on the other hand, was developed. In the group of patients, 50 (50%) IAR and 50(50%) PAR. Mean of the age in patients with AR was 34.36 ± 12.83 and in the control group: 34.18 ± 11.9. The patients were divided into two groups. 26(52%) female and 24 (48%) males. Results. We discovered greater blood IgE levels in AR patients compared to controls, although there was no statistically significant difference. (p = 0.455), but there was no significant difference for IL-4. (p = 0.91) We found no substantial differences in IL-5 serum levels among AR patients and control persons. The serum levels of IL-13 in.the control group were lower compared to the group of patients with IAR (p = 0.296). Conclusion: - Despite large differences in the amounts for There was no significant difference in the cytokines evaluated in our groups. differences are seen. This, we assume, is due to the small number of participants in each group. More research should be carried out. To demonstrate the function of IL-4, IL-5, IL-13, and IgE in the genesis and severity of sickness. [ABSTRACT FROM AUTHOR]