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1,840 results on '"Angela Wright"'

10. Brave mum shares horrifying torture she endured at hands of partner for 17 years; During her 17-year relationship with evil sadist, Steven Blades, Angela Wright was subjected to countless beatings, had her leg broken, had a gun placed in her mouth and was repeatedly raped

Subjects
Rape, Torture, General interest, News, opinion and commentary
Abstract

Byline: By, Sophie Halle-Richards When she woke up each morning, all Angela could focus on was how she'd get through the day. Her bones were broken, her eyes black and [...]

Published
2021

15. Angela Wright Marshall

Subjects
Business, Business, regional
Abstract

Byline: Daily Record Staff Dr. Angela Wright Marshall Physician Entrepreneur Comprehensive Women's Health What do you consider your most significant professional accomplishment? My most significant professional accomplishment was creating a [...]

Published
2020

17. Suddenly stricken: four years ago, Angela Wright had an epileptic seizure that changed her life. Find out how she regained control of her health

Author

Tucker, Libby

Subjects
Epileptics -- Health aspects -- Social aspects, Epilepsy -- Health aspects -- Social aspects, Education, Family and marriage, General interest
Abstract

Angela Wright was on her way to swim-team practice one morning when she began to shake uncontrollably. Then she passed out. Scared that their daughter might die, Angela's parents rushed [...]

Published
2007

22. Debating Clarence Thomas: Angela Wright Tells Her Story

Subjects
Judicial candidates, General interest
Abstract

To listen to this broadcast, click here: http://www.npr.org/templates/story/story.php?storyId=15113601 MICHEL MARTIN, host: I'm Michel Martin, and this is TELL ME MORE from NPR News. Today, conversations about language, sexuality and power. [...]

Published
2007

27. Dale Townshend, Angela Wright (eds), Ann Radcliffe, Romanticism and the Gothic

Author

Talairach-Vielmas, Laurence

Subjects
roman noir, romantisme, the Gothic, Gothique, romanticism
Abstract

1764 marked both the publication of the first Gothic story, Horace Walpole’s The Castle of Otranto (1764), and the birth of one of the most popular Gothic writers of the romantic period—Ann Radcliffe. 250 years later, Ann Radcliffe, Romanticism and the Gothic, edited by Dale Towshend and Angela Wright, freshly re-examines Radcliffe’s work, looking at the impact and reception of her œuvre and its relationship to the Romantic literary and cultural contexts. If the Gothic was considered as low m...

Published
2015

33. Angela Wright Combes

Author

Cole, Joseph E., Turner, Orren Jack, Cole, Joseph E., and Turner, Orren Jack

Abstract

Black and white bridal photograph by Orren Jack Turner of the daughter-in-law of Willard Combes. Verso reads "Mrs. Willard Combes" but it is believed that this should say "Mrs. Richard W. Combes." The bride is Angela Wright Combes.

Published
1949

34. Multistudy Research Operations in the ICU: An Interprofessional Pandemic-Informed Approach

Author

Deborah J. Cook, MD, FRCPC, Erick H. Duan, MD, FRCPC, France J. Clarke, RRT, Karlo Matic, MD, Sarah Culgin, MSc, Laurel Kelly, MSc, Katlynne S. Nelson, MSc, Christine V. Wallace, BScPhm, Mark D. Soth, MD, FRCPC, Kimberley A. Lewis, MD, FRCPC, Jill C. Rudkowski, MD, FRCPC, Dan Perri, MD, FRCPC, Tania L. Ligori, MD, FRCPC, Roman Z. Jaeschke, MD, FRCPC, Zain Chagla, MD, FRCPC, Dipayan Chaudhuri, MD, FRCPC, Angela E. Wright, PharmD, Zoe Y. Fu, PharmD, Brenda K. Reeve, MD, FRCPC, Hilary M. Lee, MD, FRCPC, Jeffrey D. Overington, MD, FRCPC, Anna Rozenberg, MD, FRCPC, Kimberly A. Bloomfield, RN, Katryn Love, RN, Jennifer L. Gain, RRT, Nicole L. Zytaruk, RN, Jason H. Cheung, MD, FRCPC, Lehana Thabane, PhD, Michelle E. Kho, PhD, for the Department of Critical Care Research Operations Committee, Waleed Alhazzani, Matthew Bell, Kimberley Bloomfield, Zain Chagla, Dipayan Chaudhuri, Jason Cheung, France Clarke, Deborah Cook, Mary Copland, Sarah Culgin, Erick Duan, Zoe Fu, Jennifer Gain, Abby Hurd, Roman Jaeschke, Hilary Lee, Katryn Love, Laurel Kelly, Michelle Kho, Kate Kim, Kimberley Lewis, Tania Ligori, Karlo Matic, Katlynne Nelson, Heather O‘Grady, Jeffrey Overington, Dan Perri, Brenda Reeve, Anna Rozenberg, Jill Rudkowski, Lois Saunders, Joanna Semrau, Mark Soth, Christine Wallace, Lily Waugh, Angela Wright, and Nicole Zytaruk

Subjects
Medical emergencies. Critical care. Intensive care. First aid, RC86-88.9
Abstract

OBJECTIVES:. Proliferation of COVID-19 research underscored the need for improved awareness among investigators, research staff and bedside clinicians of the operational details of clinical studies. The objective was to describe the genesis, goals, participation, procedures, and outcomes of two research operations committees in an academic ICU during the COVID-19 pandemic. DESIGN:. Two-phase, single-center multistudy cohort. SETTING:. University-affiliated ICU in Hamilton, ON, Canada. PATIENTS:. Adult patients in the ICU, medical stepdown unit, or COVID-19 ward. INTERVENTIONS:. None. MEASUREMENTS AND MAIN RESULTS:. An interprofessional COVID Collaborative was convened at the pandemic onset within our department, to proactively coordinate studies, help navigate multiple authentic consent encounters by different research staff, and determine which studies would be suitable for coenrollment. From March 2020 to May 2021, five non-COVID trials continued, two were paused then restarted, and five were launched. Over 15 months, 161 patients were involved in 215 trial enrollments, 110 (51.1%) of which were into a COVID treatment trial. The overall informed consent rate (proportion agreed of those eligible and approached including a priori and deferred consent models) was 83% (215/259). The informed consent rate was lower for COVID-19 trials (110/142, 77.5%) than other trials (105/117, 89.7%; p = 0.01). Patients with COVID-19 were significantly more likely to be coenrolled in two or more studies (29/77, 37.7%) compared with other patients (13/84, 15.5%; p = 0.002). Review items for each new study were collated, refined, and evolved into a modifiable checklist template to set up each study for success. The COVID Collaborative expanded to a more formal Department of Critical Care Research Operations Committee in June 2021, supporting sustainable research operations during and beyond the pandemic. CONCLUSIONS:. Structured coordination and increased communication about research operations among diverse research stakeholders cultivated a sense of shared purpose and enhanced the integrity of clinical research operations.

Published
2022
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35. Spice Girls of the 60's anniversary pledge to the Children's Foundation charity; Singing sensations The Barry Sisters, including Angela Wright from New Marske, were the toast of Tyneside in the late 50s and 1960s

Subjects
Charitable foundations, General interest, News, opinion and commentary
Abstract

Byline: nechronicle Administrator They were the Spice Girls of their day -- three confident North East lasses with angelic voices and good looks to match. Singing sensations The Barry Sisters [...]

Published
2015

36. Spice Girls of the 60's anniversary pledge to the Children's Foundation charity; Singing sensations The Barry Sisters, including Angela Wright from New Marske, were the toast of Tyneside in the late 50s and 1960s

Subjects
Charitable foundations, General interest, News, opinion and commentary
Abstract

Byline: nechronicle Administrator They were the Spice Girls of their day -- three confident North East lasses with angelic voices and good looks to match. Singing sensations The Barry Sisters [...]

Published
2015

37. Systemic Antimicrobial Therapy for Diabetic Foot Infections: An Overview of Systematic Reviews

Author

Angela Wright, Stephen Wood, Janath De Silva, and J. Simon Bell

Subjects
diabetic foot infection, systemic antibiotic treatment, diabetic foot ulcer, antimicrobial treatment, systematic review, Therapeutics. Pharmacology, RM1-950
Abstract

Diabetic foot infections (DFIs) are a common complication of diabetes; however, there is clinical uncertainty regarding the optimal antimicrobial selection. The aim of this review was to critically evaluate the recent systematic reviews on the efficacy and safety of systemic (parenteral or oral) antimicrobials for DFI. Medline, Embase, CENTRAL, and CINAHL databases and the PROSPERO register were searched from January 2015 to January 2023. Systematic reviews with or without meta-analyses on systemic antimicrobials for DFI, with outcomes of clinical infection resolution or complications, were included. Of the 413 records identified, 6 systematic reviews of 29 individual studies were included. Heterogeneity of individual studies precluded meta-analysis, except for ertapenem versus piperacillin–tazobactam (RR 1.07, 95% CI [0.96–1.19]) and fluoroquinolones versus piperacillin–tazobactam (RR 1.03, 95% CI [0.89–1.20]) in one review. The application of the AMSTAR-2 tool determined two reviews to be of high quality. There was no statistical difference in the clinical resolution of infections for 24 different antimicrobial regimens (penicillins, cephalosporins, carbapenems, fluoroquinolones, vancomycin, metronidazole, clindamycin, linezolid, daptomycin, and tigecycline). However, tigecycline did not meet non-inferiority against ertapenem ± vancomycin (absolute difference −5.5%, 95% CI [−11.0–0.1]) and was associated with a higher incidence of adverse drug events. There is minimal systematic review evidence to suggest one regimen is superior to another for DFI.

Published
2023
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39. Angela Wright: Use technology to achieve more flexibility and greater value

Subjects
Workers -- Technology application, Information technology -- Usage, Information technology, Technology application, Business, Human resources and labor relations
Abstract

Allowing individuals a choice in selecting and structuring their benefits packages has been made much more feasible by changes in information technology. But the revolution in means of communication has [...]

Published
2014

40. Interview with Angela Wright by Dhanya Babu, 2021-03

Author

To order a reproduction or to inquire about permission to publish, please contact the Spelman College Archivist at https://www.spelman.edu/about-us/archives with the web URL or handle identification number. (Copyright claimant) and To order a reproduction or to inquire about permission to publish, please contact the Spelman College Archivist at https://www.spelman.edu/about-us/archives with the web URL or handle identification number. (Copyright claimant)

42. The Angela Wright case

Author

Effron, Seth

Subjects
Charlotte Observer (Newspaper) -- Management, Sexual harassment -- Investigations, Business, Literature/writing, Mass communications, Publishing industry
Abstract

The Charlotte Observer found itself in the role of newsmaker rather than news reporter when it was revealed that Angela Wright had worked for the EEOC and could substantiate indirectly Anita Hill's sexual harassment experiences. The newspaper adopted a policy of protecting Wright and banned its own reporters from discussing her with other journalists. The paper was criticized for limiting access to a news story when one of its own practitioners is subjected to media scrutiny.

Published
1991

43. Angela Wright: The factors impacting flex design

Author

Wright, Angela

Subjects
Employee motivation -- Economic aspects, Business, Human resources and labor relations
Abstract

Byline: Angela Wright Flexible benefits (http://www.employeebenefits.co.uk/benefits/flexible-benefits) seem to be tailor-made for the current climate. Demographic and macro-economic changes such as an ageing population and increasing student debt, the increased movement [...]

Published
2013

47. Economic evaluation alongside the Probiotics to Prevent Severe Pneumonia and Endotracheal Colonization Trial (E-PROSPECT): study protocol

Author

Katie Ross, Dimitra Fleming, John Marshall, Najib Ayas, François Lellouche, Justin Lys, Ryan Zarychanski, Timothy Karachi, Deborah J Cook, Marie-Claude Tremblay, Jeremy Grushka, Dan Deckelbaum, Kosar Khwaja, Tarek Razek, Donald Griesdale, John Muscedere, David Maslove, Roupen Hatzakorzian, Patrick Archambault, Feng Xie, François Lauzier, Heather Smith, David Williamson, Emmanuel Charbonney, John Granton, Alyson Takaoka, Kwadwo Kyeremanteng, Miranda Hunt, Ian Ball, Victoria McCredie, Michaël Chasse, Jennifer LY Tsang, Jordi Mancebo, Peter Dodek, Emilie Belley-Cote, Neala Hoad, Melissa Shears, Mark Soth, Tracy Campbell, Geeta Mehta, Daniel Chen, Shane English, Maureen Meade, John Kim, Jie Meng, Richard Johnston, Jennie Johnstone, Norman Dewhurst, Panagiota Giannakouros, Laura García, John Ma, Dev Jayaraman, Pierre Cardinal, Vincent Issac Lau, John C Marshall, John Basmaji, Deborah Cook, Erick Duan, France Clarke, Mary Copland, Marnie Jakab, Nicole Zytaruk, Christa Connolly, Denise Davis, Catherine Eaton, Tracy Gallinas, Jean Lee-Yoo, Connie Lukinuk, Leia Musielak, Nancy Pavunkovic, Joy Pelayo, Kaitlyn Phillips, Catherine Pracsovics, Julia Raimondo, Vida Stankus, Christine Wallace, Angela Wright, Crystal Young, Katrina Fimiani, Lori Hand, Harjot Jagdey, Lisa Klotz, Alexana Sabev, Nevena Savija, Deanne Cosentino, Diane Lourenco, Julie Misina, Gita Sobhi, Mashari Alghuroba, Alia Khaled, Lauren Locco, Tina Millen, Ryan Vaisler, Maya Biljan, Brittany Marriott, Jan Frieich, Jennifer Hodder, Imrana Khalid, Julie Lee, Yoon Lee, Pragma Roy, Kurtis Salway, Gyan Sandhu, Marlene Santos, Orla Smith, Melissa Wang, Ann Dowbenka, Ann Kosinski, Terri Norrie, Ranjit Parhar, Laura Parsons, Johanna Proceviat, Gitana Ramonas, Mae Yuen, Maria Agda, Victoria Alcuaz, Betty Jean Ashley, Kelsey Brewer, Janice Palmer, Glen Brown, Mara Pavan, Stephen Lapinsky, Laveena Munshi, Maedean Brown, Brittany Giacomino, Alan Kraguljac, Sumesh Shah, Erik Tamberg, Laura Vergeer, Doret Cheng, Gagan Grewal, Anew Han, Holly Leung, Ioanna Mantas, Hilary Roigues, Anew Wyllie, Alexis Turgeon, Danny Barriault, David Bellemare, Anick Boivin, Sarah-Judith Breton, Eve Cloutier, Marjorie Daigle, Charles Delisle-Thibeault, Stéphanie Grenier, Gabrielle Guilbault, Caroline Léger, Catherine Ouellet, Élisabeth Gagne, Julie Gaueau, Claire Grégoire, Véronique Labbé, Ariane Laprise-Rochette, Caroline Ouellet, Mélanie Samson, Marie-David Simoneau, Virginie Turcotte, Tuong-Vi Tran, Lauralyn McIntyre, Joe Pagilarello, Gianni D’Egidio, Mike Hartwick, Jonathon Hooper, Gwynne Jones, Dal Kubelik, Hilary Meggison, Sherissa Microys, Dave Neiliovitz, Guiseppe Pagliarello, Rakesh Patel, Jo Po, Peter Reardon, Erin Rosenberg, Aimee Sarti, Anew Seely, Shelley Acres, Brigette Gomes, Heather Langlois, Liane Leclair, Sydney Miezitis, Kaitlyn Montroy, Rebecca Porteous, Shawna Reddie, Amanda Van Beinum, Allyshia Van Tol, Irene Watpool, Wendy Aikens, Marianne Cox, Anne-Marie Dugal, Susan Fetzer, Kathy Fraser, Jennifer Kuhn, Rob MacLeod, Susanne Richard, Dawn Rose, Sherry Weir, Bill Henderson, Mypinder Sekhon, Denise Foster, Suzie Logie, Judy Yip, Margaret Herridge, s Alberto Goffi, Eyal Golan, Elizabeth Wilcox, Jaimie Archer, Paulina Farias, Brooke Fraser, Cheryl Geen-Smith, Barbara Kosky, Anea Matte, Christina Pugliese, Priscila Robles, Lia Stenyk, Cristian Urrea, Karolina Walczak, Kyung Ae, Jane Ascroft, Fatima Haji, Rajvinder Kaur, Jane Lui, Sophia Mateo, Nga Pham, Tam Pham, Matthew Suen, Jennifer Teng, Gordon Wood, Daniel Ovakim, Fiona Auld, Gayle Camey, Ralph Fleming, Jennifer Good, Mandeep Manhas, Karin Boyd, Jane Dheere, Priscilia Robles, Muhammad Walid, Jill Westlund, Yoan Lamarche, Soazig Leguillan, Karim Serri, Colin Verdant, Yanick Beaulieu, Patrick Bellemare, Philippe Bernard, Marc Giasson, Véronique Brunette, Alexanos Cavayas, Émilie Lévesque, Halina Labikova, Julia Lainer Palacios, Marie-Ève Langlois, Virginie Williams, Thuy Anh Nguyen, Valérie Phaneuf, Frédérick D’Aragon, Charles St-Arnaud, Hector Quiroz, Virginie Bolduc, Elaine Carbonneau, Joannie Marchand, Marie-Hélène Masse, Sylvie Cloutier, Marianne Guay, Line Morin, Jessie Nicolson, Isabelle Paquette, Patricia Roy, France Théberge, Arnold S Kristof, Peter Goldberg, Sheldon Magder, Jason Shahin, Salman Qureshi, Josie Campisi, Vasilica Botan, Anissa Capilnean, Alyssa Corey, Annick Gagné, Jasmine Mian, Kathleen Normandin, Ash Gursahaney, David Hornstein, Robert Salasidis, Patrizia Zanelli, Norine Alam, Tonia Doerksen, Ariane Lessard, Gilbert Matte, Marie-France Robert, Martin Girard, Pierre Aslanian, Sylvain Belisle, François-Martin Carrier, Ané Denault, Jean-Gilles Guimond, Antoine Halwagi, Paul Hébert, Christopher Kolan, Nicholas Robillard, Fatna Benettaib, Dounia Boumahni, Casey Bourdeau Caporuscio, Marie-Ève Cantin, Virginy Côté-Gravel, Ali Ghamraoui, Martine Lebrasseur, Lancelot Legene Courville, Stéphanie Lorio, Maria Trinidad Maid, Nicole Poitras, Romain Rigal, Maya Salame, Valérie Tran, Katie Bacon, Nathalie Boueau, Cecilia Carvajal, Lyne Gauthier, Julie Genon, Karine Jean, Louise Laforest, Antonietta Lembo, Sothun Lim, Jennifer Morrissette, France Pagé, Lucie Pelletier, Marie-Christine Roigue, Jim Kutsiogiannis, Raiyan Chowdhury, Jon Davidow, Curt Johnston, Kim Macala, Sam Marcushamer, Darren Markland, Doug Matheson, Damian Paton-Gay, David Zygun, Nadine Grant, Tayne Hewer, Pat Thompson, Maggie Ge, Janny Hall, Sharon Matenchuk, Osama Loubani, Rick Hall, Robert Green, Diana Gillis, Lisa Julien, Laura Lee Magennis, Tamara Mitterer, Joanna Arsenault, Kim Bruce-Payne, Patti Gallant, Gord Boyd, Christine D’Arsigny, John Over, Jason Erb, Chris Parker, Stephanie Sibley, Tracy Boyd, Ilinca Georgescu, Danielle Muscedere, Cathy Baker, Jennifer Engel, Jennifer Fleming, Lisa Roderick, Shelley Silk, Marcy Spencer, Michelle Tryon, Marcus Blouw, Kendiss Olafson, Bojan Paunovic, Oliver Gutieror, Nicole Marten, Sherri Lynn Wingfield, Marnie Boyle, Halyna Ferens, Debbie Hrabi, Beata Kozak, Chantal MacDonald, Julie Muise, Eileen Campbell, Susie Imerovski, Athena Ovsenek, Rebecca Rondinelli, Teresa Longfield, Amy Moyer, Faith Norris, Janice Sumpton, Karina Teterycz, Brenda Reeve, Karen Bento, Megan Davis, Will Dechert, Krista Gallo, Barbara Longo, Courtney Mullen, Elysia Skrzypek, Laurenne Wierenga, Wesam Abuzaiter, Lynda Amorim, Rosemarie Bauer, Rachel Damota, Thoa Ho, Nicole Macdougall, Mary Thornewell, Lara Pe, Jennifer Visocchi, Auey Bhairo, Halyna Ferenes, Debra Kubin, Dawn-Lee McLaughlin, Maria Valente, Steve Reynolds, Suzette Willems, Tina Sekhon, Sebastien Trop, Alexana Binnie, Ronald Heslegrave, Kim Sharman, Zaynab Panchbhaya, Rakhi Goel, Kim Kozluk, Julianne Labelle, Hina Marsonia, Cecillia Scott, Dave Nagpal, Tracey Bentall, Jessica Sturt-Smith, Michelle Alexander, Tammy Ellis, Mindy Muylaert, Cindy Paczkowski, Wendy Sligl, Sean Bagshaw, Nadia Baig, Lorena McCoshen, Katrina Alexanopoulos, Sherri Bain, Michelle Brandt, Cathy Constable, Kari Douglas, Shaleen Maharaj, Sabrina Travers, Tom Stelfox, Philippe Couillard, Christopher Doig, Ken Parhar, Joshua Booth, Cassidy Codan, Stacy Ruddell, Candice Cameron, Rhonda Edison, Anne Martin, Breanna Mina, Dan Niven, Luc Berthiaume, Jonathan Gaudet, Gina Fleming, Mercedes Carmargo, Beverly Hoekstra, Rita Caporuscio, Rachel Kressner Falvo, Carmelina Maxwell, Karmen Plantic, François Marquis, Han Tin Wang, Francis Toupin, Stephane Ahern, Brian Laufer, Marc Brosseau, Pauline Dul, Johanne Harvey, Lotthida Inthanavong, Danae Tassy, Helen Assayag, Maude Bachand, Marysa Betournay, Karine Daoust, Kristine Goyette, Marceline Quach, Paul Hosek, Bill Plaxton, Catherine Armstrong, Rhonda Barber, William Dechert, Janelle Ellis, Kayla Fisk, Melissa Gabnouri, Emilie Gordon, Rebecca Haegens, Lisa Halford, Brooklynn Hillis, Rebecca Jesso, Jenn McLaren, Elliot McMillan, Mariska Pelkmans, Matthew Rekman, Sylvia Sinkovitis, Monica Truong, Michelle White, Noah Bates, Susan Bryden-Cromwell, Lisa Cha, Colleen Cameron, Aminah Deen, Sheri DiGiovanni, Anders Foss, Esther Lee, Heidi MacGregor, Esther Galbraith, Robyn McArthur, Julie McGregor, Keith Miller, Sharon Morris, Shelley Parker, Candice Smith, Joanna Stoglow, Jennifer Tung, Melissa Vos, Neill Adhikari, Ane Amaral, Ane Carlos, Brian Cuthbertson, Rob Fowler, Damon Scales, Navjot Kaur, Nicole Marinoff, Adic Perez, Jane Wang, Katrina Hatzifilalithis, John Iazzetta, Chrys Kolos, Ingrid Quinton, Paul Lysecki, Joseph Berlingieri, Sameer Shaikh, Steven Skitch, Hala Basheer, Kathy Bruder, Jane Cheng, Kaiser Qureshi, Celeste Thibault, Ying Tung Sia, Mathieu Simon, Pierre-Alexane Bouchard, Patricia Lizotte, Nathalie Chateauvert, Thérèse Grenier, Jean-François Bellemare, Simon Bordeleau, Christine Ouin, Benoît Duhaime, Ann Laberge, Philippe Lachance, Mélanie Constantin, Estel Deblois, Maude Dionne, Lise Lavoie, Isabelle Michel, Alexane Pépin, Sanine Poulin, Sarah Anctil, Amélie Chouinard, Louis-Étienne Marchand, Robin Roy, Roigo Cartin-Ceba, Richard Oeckler, Brenda Anderson, Lavonne Liedl, Laurie Meade, Sueanne Weist, Anna Bartoo, Debbie Bauer, Vince Brickley, Shaun Bridges, Greg Brunn, Jennifer Eickstaedt, Jill Randolph, Sandy Showalter, Melissa Wendling, Robert Taylor, Margaret Cytron, Kim Fowler, Katie Krause, Jackie O’Brien, Marianne Tow, Kaitlin Stassi, Abdulaziz Al-Dawood, Haytham Tlayjeh, Alaaeldien Ghanem, Ahmad Hassanien, Mohamed Hegazy, Ashraf El Sharkawi, Felwa Bin Humaid, Hala Alanizi, Nadyah Alanizy, Njoud Al Bogami, Mohammed Muhaidib, Jawaher Gramish, Randa Alsomali, Nora Devera, and Marjane Villafranca

Subjects
Medicine
Abstract

Introduction Ventilator-associated pneumonia (VAP) is a common healthcare-associated infection in the intensive care unit (ICU). Probiotics are defined as live microorganisms that may confer health benefits when ingested. Prior randomised trials suggest that probiotics may prevent infections such as VAP and Clostridioides difficile–associated diarrhoea (CDAD). PROSPECT (Probiotics to Prevent Severe Pneumonia and Endotracheal Colonization Trial) is a multicentre, double-blinded, randomised controlled trial comparing the efficacy of the probiotic Lactobacillus rhamnosus GG with usual care versus usual care without probiotics in preventing VAP and other clinically important outcomes in critically ill patients admitted to the ICU.Methods and analysis The objective of E-PROSPECT is to determine the incremental cost-effectiveness of L. rhamnosus GG plus usual care versus usual care without probiotics in critically ill patients. E-PROSPECT will be performed from the public healthcare payer’s perspective over a time horizon from ICU admission to hospital discharge.We will determine probabilities of in-ICU and in-hospital events from all patients alongside PROSPECT. We will retrieve unit costs for each resource use item using jurisdiction-specific public databases, supplemented by individual site unit costs if such databases are unavailable. Direct costs will include medications, personnel costs, radiology/laboratory testing, operative/non-operative procedures and per-day hospital ‘hoteling’ costs not otherwise encompassed. The primary outcome is the incremental cost per VAP prevented between the two treatment groups. Other clinical events such as CDAD, antibiotic-associated diarrhoea and in-hospital mortality will be included as secondary outcomes. We will perform pre-specified subgroup analyses (medical/surgical/trauma; age; frailty status; antibiotic use; prevalent vs no prevalent pneumonia) and probabilistic sensitivity analyses for VAP, then generate confidence intervals using the non-parametric bootstrapping approach.Ethics and dissemination Study approval for E-PROSPECT was granted by the Hamilton Integrated Research Ethics Board of McMaster University on 29 July 2019. Informed consent was obtained from the patient or substitute decision-maker in PROSPECT. The findings of this study will be published in peer-reviewed journals.Trial registration number NCT01782755; Pre-results.

Published
2020
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49. Career journalist Angela Wright described as outspoken, popular

Author

Fulwood, Sam, III

Subjects
United States. Senate. Committee on the Judiciary -- Political activity, United States. Equal Employment Opportunity Commission -- Officials and employees, Wright, Angela D. -- Testimony, Sexual harassment -- Investigations
Published
1991

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